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Found results for
 patents
1.
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APPLICATION OF CPE IN PREPARATION OF DRUG FOR PROMOTING IN-SITU NEUROGENESIS AND TREATING AGING-RELATED NEURODEGENERATIVE DISEASES
| Application Number |
CN2022074380 |
| Publication Number |
2023/087548 |
| Status |
In Force |
| Filing Date |
2022-01-27 |
| Publication Date |
2023-05-25 |
| Owner |
- INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES (China)
- BEIJING INSTITUTE OF GENOMICS, CHINESE ACADEMY OF SCIENCES/CHINA NATIONAL CENTER FOR BIOINFORMATION (China)
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| Inventor |
- Tang, Tieshan
- Guo, Caixia
- Liu, Hongmei
- Zhou, Bo
- Yao, Fuwen
- Jiang, Dongfang
- Li, Tingting
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Abstract
Provided is an application of carboxypeptidase E (CPE) in preparation of a drug for promoting in-situ neurogenesis and treating aging-related neurodegenerative diseases. The drug contains a substance for promoting or improving the expression of a CPE coding gene, or contains a substance for promoting or improving CPE activity or content. The expression of the CPE is improved, so that neurogenesis of the brain SVZ and DG can be remarkably enhanced, NSC proliferation and nerve differentiation of a DG area of a diseased mouse can further be promoted, a cognitive function of an AD mouse is remarkably improved, and a target is provided for development and promotion of in-situ neurogenesis, treatment of aging-related neurodegenerative diseases and preparation of related drugs.
IPC Classes ?
- A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
- C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
- A61P 25/00 - Drugs for disorders of the nervous system
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2.
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DNA MOVABLE TYPE STORAGE SYSTEM AND METHOD
| Application Number |
CN2021098663 |
| Publication Number |
2022/012216 |
| Status |
In Force |
| Filing Date |
2021-06-07 |
| Publication Date |
2022-01-20 |
| Owner |
BEIJING INSTITUTE OF GENOMICS CHINESE ACADEMY OF SCIENCES / CHINA NATIONAL CENTER FOR BIOINFORMATION (China)
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| Inventor |
- Chen, Fei
- Bu, Dongbo
- Ma, Guannan
- Wang, Chenyang
- Xing, Jing
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Abstract
A DNA movable type storage system and method. The method comprises: providing a content movable type physical library and an index movable type physical library; splitting data to be stored in a target file into a plurality of data elements and marking index information for the data elements, enabling content information of the data elements to correspond to specific content movable type oligonucleotide fragments in the content movable type physical library, and enabling the index information to correspond to specific index movable type oligonucleotide fragments in the index movable type physical library; and then, connecting the content movable type oligonucleotide fragments and the index movable type oligonucleotide fragments to form DNA movable type units, and a plurality of DNA movable type units forming a DNA storage file in which all data elements to be stored are stored. A DNA movable type physical library can be synthesized in one step, multiple instances of repeated usage and free combination greatly reduce the DNA synthesis costs, the labor and time investment involved in multiple instances of designing and synthesis of DNA fragments can be avoided, and the cost burden caused due to the introduction of a large number of error correction sequences is avoided.
IPC Classes ?
- G06F 16/172 - Caching, prefetching or hoarding of files
- G06F 16/174 - Redundancy elimination performed by the file system
- H03M 7/06 - Conversion to or from weighted codes, i.e. the weight given to a digit depending on the position of the digit within the block or code word the radix thereof being a positive integer different from two
- G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
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