Abstract

This provides a system and method for analyzing and diagnosing conditions, such as cancer, based upon stained tissue sample slides prepared by users from patient tissue taken, for example, in a biopsy procedure. A convolutional neural network (CNN) is generated at training time. Slide images are acquired/scanned, and individual cell nuclei from the images are annotated, using IHC. H&E images are acquired/scanned prior to a washout intermediate step from the same slides/tissue samples. IHC is performed on the same tissue layer, which was scanned and used to retrospectively annotate the H&E WSI. IHC is used to annotate a ground truth mask for machine learning. The resultant process achieves a high degree of spatial resolution in detecting individual IHC positive nuclei, yielding process that is almost entirely automated, employing materials that are commonly available in clinical practice. In runtime, users access the CNN to perform analysis on patient slides.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation

Abstract

An MNP machine provides a bias field consisting of a low frequency alternating magnetic field and possibly a static magnetic field to a volume in possibly different directions; RF drive coils driven at an FMR/EPR frequency of MNPs in the bias field, and pickup coils or magnetometers measuring the magnetization induced in the MNPs by the bias fields and possibly the RF absorption. The computer derives MNP MPS/MSB spectra, magnetic particle images, or heats the MNPs using the EPR/FMR frequency field. A method of imaging or localizing the MNPs includes applying a magnetic field gradient; applying RF at an EPR/FMR frequency of the MNPs; sweeping magnetic bias field strength or RF frequency to sweep a resonance surface; applying RF at the EPR/FMR frequency, observing EPR/FMR resonances; rotating the magnetic bias field relative to the subject and resweeping the surface; and reconstructing a three-dimensional distribution of MNPs.

IPC Classes  ?

• A61N 2/02 - Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
• A61N 2/00 - Magnetotherapy
• G01K 7/38 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using magnetic elements, e.g. magnets, coils the variations of temperature influencing the magnetic permeability
• G01R 33/389 - Field stabilisation
• G01R 33/60 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance using electron paramagnetic resonance

Abstract

A one-way tracheostomy valve includes an open-bore assembly having a first end that defines a first diameter and a second end opposite the first end that defines a second diameter. A one-way occluder is fixedly arranged to the second end of the open-bore assembly. A rotatable cover is arranged on the second end and configured to rotate around the second end.

IPC Classes  ?

• A61M 16/04 - Tracheal tubes
• A61M 16/20 - Valves specially adapted to medical respiratory devices
• A61M 39/22 - Valves or arrangement of valves
• A61F 2/20 - LarynxesTracheae combined with larynxes or for use therewith

Abstract

A bioresorbable nanofibrous scaffold having nanofibers of silk fibroin and polyhydroxybutyrate (PHB). The silk fibroin and the PHB are arranged so that an area of the bioresorbable nanofibrous scaffold has concentrated amounts of the silk fibroin and another area of the bioresorbable nanofibrous scaffold has concentrated amounts of the PHB. The silk fibroin and the PHB may be coaxially arranged such that the PHB forms a center of the nanofibers and the silk fibroin surrounds the PHB concentrically, or the silk fibroin and the PHB may be arranged so that the silk fibroin and the PHB are layered.

IPC Classes  ?

• D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
• D01F 8/02 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from cellulose, cellulose derivatives, or proteins
• D01D 1/02 - Preparation of spinning solutions
• D01D 5/00 - Formation of filaments, threads, or the like
• D04H 1/435 - Polyesters
• D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather

Abstract

A system and method for repairing a damaged peripheral nerve is provided. A coupler includes a stabilizing assembly applied to a distal end of a damaged area of the nerve and applied to a proximal end of the damaged area, the coupler adapted so that the proximal end and the distal end are maintained in a stabile abutting relationship in which nerve repair can occur. A chamber is placed in proximity to the damaged area, having a therapeutic agent. Illustratively, the distal end and the proximal end are severed from each other. The coupler can define one of (a) coupler halves that surround the proximal end and the distal end and allow fixing members to be applied to the proximal end and the distal end and (b) cuffs that engage, and are fixed to, each of the proximal end and the distal end and are engaged by overlying coupler halves.

IPC Classes  ?

• A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

Systems and methods characterize tissue integrity, viability or health of bone and soft tissue through observing perfusion of those tissues, providing guidance to surgeons addressing orthopedic and other trauma. The system exposes a bolus of fluorophore administered to a patient to intense, brief, pulses of infrared excitation light while imaging the fluorophore in tissue with a gated, multi-pulse integrating, CMOS image sensor to obtain a sequence of images. The sequence of images is displayed or processed to map tissue perfusion parameters and/or to map a probability of tissue survival. A method of surgery uses the system during surgery to display to a surgeon the tissue perfusion parameters and/or map of probability of tissue survival, the surgeon then may either revascularize or remove tissue of low probability of survival to improve healing and reduce risk of infection.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• G01N 21/91 - Investigating the presence of flaws, defects or contamination using penetration of dyes, e.g. fluorescent ink
• G01Q 60/20 - Fluorescence

Abstract

A tissue ablation system and method are provided. The system includes a catheter including a distal electrode tip having at least one tip electrode, at least one return electrode positionable independently of the tip electrode, and a voltage generator circuit electrically connected to the tip electrode and to the return electrode. The tip electrode and the return electrode include a dielectric or other non-conductive surface layer. The voltage generator circuit applies a voltage differential across the tip electrode and the return electrode such that the tip electrode and the return electrode are given opposite polarity. Tissue located between the tip electrode and the return electrode acts as a capacitive dielectric medium in which an electric field is present and is not dependent on current flow between the tip electrode and the return electrode, and the electric field induces electroporation of tissue cells in a vicinity of the distal electrode tip.

IPC Classes  ?

• A61B 18/16 - Indifferent or passive electrodes for grounding
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
• A61B 18/14 - Probes or electrodes therefor

Abstract

In various aspects and embodiments, the invention provides a tissue engineered neuromuscular interface comprising: an extracellular matrix core; the extracellular matrix core comprising: a population of neurons at a first end of the extracellular matrix core, the population of neurons having axons extending at least a portion of the way along the extracellular matrix core; wherein the population of neurons is selected from the group consisting of one or more motor neurons, one or more motor neurons co-cultured with one or more sensory neurons, and a co-aggregate comprising one or more motor neurons and one or more sensory neurons.

IPC Classes  ?

• A61L 27/38 - Animal cells
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

A probe device having a hollow probe with an inside surface, an outside surface, an open end, a closed end, and an aperture between the open end and the closed end. A scintillating material is on the inside surface of the probe such that it is exposed through the aperture. An imaging device images an imaging window generated by the scintillating material. The images may be assessed to determine seed dosage rate, seed dwell time, seed spot position, and/or cumulative dose.

IPC Classes  ?

• A61B 6/42 - Arrangements for detecting radiation specially adapted for radiation diagnosis
• G01T 1/02 - Dosimeters
• G01T 1/16 - Measuring radiation intensity
• A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes

Abstract

This invention provides an ionization chamber (IC) for measuring dose rate in a radiation beam, and method for use of the same. The IC includes a housing having a first side and a second side, each electrically connected to an electrometer assembly. The housing defines a sealed chamber adapted to receive a fill gas therein. A variable pressure source is interconnected to the sealed chamber, and is constructed an arranged to provide the fill gas into the sealed chamber in a variable pressure range that is less than one ambient atmosphere to a plurality of atmospheres. A processor receives information on the current dose rate, and based upon the information, instructs the pressure source to provide the fill gas to the chamber at a predetermined pressure level. The variable pressure range can vary from near vacuum to hyperbaric. The fill gas can be ambient air or another acceptable gas or mixture of gases.

IPC Classes  ?

• G01T 1/185 - Measuring radiation intensity with ionisation-chamber arrangements
• H01J 47/02 - Ionisation chambers
• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation
• H01J 47/04 - Capacitive ionisation chambers, e.g. the electrodes of which are used as electrometers
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

The present disclosure relates to computer-implemented systems for identifying a patient with cystic fibrosis as having a high risk for upper respiratory infections or systemic inflammation, based on the patient's stool microbiota. The systems use machine learning models trained with data comprising (a) risk classifications for subjects with cystic fibrosis and (b) stool microbiota information for each of the subjects. The present disclosure also relates to methods of reducing frequency and/or number of upper respiratory infections in a patient with cystic fibrosis. The present disclosure also relates to methods of identifying a patient with cystic fibrosis (CF) as having a high risk for frequent upper respiratory infections or high systemic inflammation based on the patient's stool microbiota.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• G16B 40/20 - Supervised data analysis

Abstract

Embodiments of the present disclosure pertain to methods of assessing glioma in a subject by (1) receiving a plurality of measured biomarker levels of the subject; and (2) assessing glioma in the subject based on the measured biomarker levels by at least correlating differentially expressed levels of the measured biomarkers to at least one of (a) diagnosis of glioma, (b) progression of glioma, (c) treatment outcome, and/or (d) tumor burden. The methods of the present disclosure also include a step of (3) making a treatment decision based on the assessment. Additional embodiments of the present disclosure pertain to systems for assessing glioma in a subject.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A chimeric protein encoded by an expression plasmid is provided. The chimeric protein comprises an extracellular of a pathogen-binding receptor and an intracellular domain of an innate immune signaling protein, such as the TLR family of receptors.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 39/42 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum viral
• A61P 31/14 - Antivirals for RNA viruses
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

This invention provides an expandable endotracheal tube (ETT) and method for use of the same, including a frame having a plurality of hoops joined by longitudinal ribs, the hoops formed into a compressed configuration with torsional spring force imparted thereby, a collapsible shell covering the frame that defines a sealed tube between a proximal end and a distal end, and a retaining structure that maintains the hoops in the compressed configuration with the frame and the shell defining a compressed outer diameter. The retaining structure is selectively releasable to cause to the frame and the shell to expand to an expanded diameter that is greater than the compressed diameter, and/or can include a member that passes through a plurality of holes located along overlapping circumferential positions of the frame and the shell folded therearound. The retaining structure can comprise a string under tension.

IPC Classes  ?

• A61M 16/04 - Tracheal tubes
• B33Y 80/00 - Products made by additive manufacturing

Abstract

A system and method for verification of nasogastric tube (NGT) placement is provided. A fiber optic light guide includes a proximal end with a light source connection and a distal end having a light emitting tip. The light guide is constructed and arranged for insertion into a lumen of the NGT. A stop that prevents the distal end of the light guide from exiting a distal end of the NGT. The stop is adapted to engage a connector on the proximal end of the NGT. The light emitting tip can comprises a radial emitter. The light source can emit light at approximately 650 nm with an output power of approximately 30W. The stop is located so that the distal end of the light guide is positioned at an offset from the distal end of the NGT when the stop engages the proximal end of the NGT.

IPC Classes  ?

• A61J 15/00 - Feeding-tubes for therapeutic purposes

Abstract

Devices and methods are disclosed for remote clinical monitoring performance of exercises using a smart resistance exercise device including a resistance band, a first handle connected to a first end of the resistance band and a second handle connected to a second end of the resistance band, a force sensing assembly operably coupled to the resistance band, and a local receiving device communicatively coupled to the force sensing assembly. The force sensing assembly of the device includes a housing, and a force sensor disposed in the housing and operatively connected to the resistance band to measure a force exerted on the resistance band. The force sensing assembly also includes a processing and communication module communicatively coupled to the force sensor to receive measurements of the force sensor and communicatively coupled to the local receiving device to transmit the measurements to the local receiving device.

IPC Classes  ?

• A63B 21/00 - Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices

Abstract

A method for rapid reconstruction of nucleic acids is described. The method comprises the stochastic reconstruction of nucleic acid by simultaneous reaction of restriction enzymes and a DNA ligase. Copy number variations (CNVs) are almost ubiquitous in cancer. In many cases, somatic CNV analysis has led to the identification of oncogenic pathways and suggested molecular-defined therapeutic targets. However, current CNV analysis is laborious and time-consuming. Here, we develop iSCORED, a one-step random genomic DNA reconstruction method that enables efficient and unbiased quantitative assessment of CNV using a real-time Nanopore sequencer. By leveraging the long concatenated reads, we generate approximately 1-2 millions genomic fragments within one hour of sequencing. Analyzing a cohort of 26 brain tumors, we demonstrate 100% concordance in CNV detection when compared to clinically validated assays. In addition, concurrent tumor methylation classification is achieved without additional tissue preparation. The entire workflow is completed within a timeframe of 120-140 minutes, with an automatically generated CNV and methylation report. The ultrafast molecular analysis could be applied in the intra-operative setting and will be crucial for making informed decisions and modifying surgical plans.

IPC Classes  ?

• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C12N 9/22 - Ribonucleases
• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
• C12Q 1/6869 - Methods for sequencing
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Abstract

A system for visualizing surgical tools in vessels includes CT or MRI for angiographic imaging; and an ultrasound machine with tracked probe and an image processor that receives the angiographic and ultrasound images. The image processor constructs a model of relevant vessels from the angiographic images; coregisters the ultrasound images to the model of relevant vessels, locates surgical tools in the ultrasound images, coregisters locations of the surgical tools to model of the relevant vessels; and displays images of the model of the relevant vessels with superimposed images of the surgical tools. A method includes modeling relevant vessels from preoperative images; coregistering the model of relevant vessels to tracked ultrasound images, localizing the relevant vessels and surgical tools in the relevant vessels; and coregistering the ultrasound images to the model of relevant vessels, then superimposing and displaying images of the surgical tools on the model of relevant vessels.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• G06T 7/00 - Image analysis
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A system includes a cylindrical phantom and a conical structure disposed in the phantom. The conical structure is shaped as a frustum and emits Cherenkov radiation when exposed to ionizing radiation. The system can be used for calibration of an MR-Linac system by exposing the system to ionizing radiation. The Cherenkov radiation can be imaged during exposure to ionizing radiation.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

A reference-point providing (RPP) device for conversion of unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA), has a wedge having a joint surface, a bottom flat surface, and a second surface, the second surface extending from the bottom flat surface to the joint surface at a thick end of the wedge and a mounting flange; the wedge fitting in a space remaining after removal of a UKA implant with the joint surface providing a reference point for determining alignment of a TKA implant. Converting a UKA to TKA with the RPP requires removing UKA implant from a femur of a patient, inserting the RPP and attaching it to the femur; using a posterior reference guide having a first paddle on a condyle of the femur and a second paddle on the RPP, to determine necessary alignment and rotation of the TKA implant; and removing the RPP.

IPC Classes  ?

• A61F 2/30 - Joints
• A61F 2/38 - Joints for elbows or knees

Abstract

This invention provides a deep learning (DL) model for fast deformable image registration using 2D sagittal cine MRI acquired during radiation therapy. A DL model for fast deformable image registration is trained using cine MRI scans acquired during MR-Linac treatments of thoracic and abdominal tumors. The model uses a pair of cine MRI images as inputs and outputs a dense motion vector field (MVF) which aligns the images. The trained model is applied to predict frame by frame motion from cine MRIs in which both cardiac and respiratory motion are visible. The number of respirations and heart beats is automatically extracted by performing peak detection on high-frequency and low-frequency components of the MVF displacements corresponding to the chest wall and cardiac regions.

IPC Classes  ?

• G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• A61N 5/00 - Radiation therapy
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G06N 3/08 - Learning methods
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS

Abstract

An MNP machine provides a magnetic bias field to a sample space; drive coils bracketing the sample space; pickup coils coupled through amplifiers to a computer; and a radio frequency (RF) stimulus coil driven at an electron paramagnetic resonance (EPR) frequency of MNPs in the bias field. The computer is configured to provide a MNP Brownian motion spectrum from the signals or magnetic particle images. A method of imaging MNP concentrations in a subject includes applying a magnetic bias field having a gradient; applying RF at an EPR frequency of the MNPs in the magnetic bias field; sweeping either magnetic bias field strength or radio frequency to sweep a surface of resonance through the subject; observing EPR resonances of the MNPs; rotating the magnetic bias field relative to the subject; repeating sweeping the surface of resonance through the subject; and reconstructing a three-dimensional model of MNP concentrations of the subject.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61N 2/00 - Magnetotherapy
• G01R 33/60 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance using electron paramagnetic resonance

Abstract

A system and method for repairing a damaged peripheral nerve is provided. A coupler includes a stabilizing assembly applied to a distal end of a damaged area of the nerve and applied to a proximal end of the damaged area, the coupler adapted so that the proximal end and the distal end are maintained in a stabile abutting relationship in which nerve repair can occur. A chamber is placed in proximity to the damaged area, having a therapeutic agent. Illustratively, the distal end and the proximal end are severed from each other. The coupler can define one of (a) coupler halves that surround the proximal end and the distal end and allow fixing members to be applied to the proximal end and the distal end and (b) cuffs that engage, and are fixed to, each of the proximal end and the distal end and are engaged by overlying coupler halves.

IPC Classes  ?

• A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
• A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
• A61M 39/00 - Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use

Abstract

In various aspects and embodiments, the invention provides a tissue engineered neuromuscular interface comprising: an extracellular matrix core; the extracellular matrix core comprising: a population of neurons at a first end of the extracellular matrix core, the population of neurons having axons extending at least a portion of the way along the extracellular matrix core; wherein the population of neurons is selected from the group consisting of one or more motor neurons, one or more motor neurons co-cultured with one or more sensory neurons, and a co-aggregate comprising one or more motor neurons and one or more sensory neurons.

IPC Classes  ?

• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61B 5/01 - Measuring temperature of body parts
• A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
• A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof

Abstract

This invention provides a system for automation of a pathology process, which includes a processor having trained artificial intelligence (AI) modules operating in association therewith, adapted to receive image data from camera images of whole tissue acquired by a camera assembly and whole slide images (WSIs) of inked and segmented tissue samples. A mask produces image results for tissue with holes and free of holes, and a filter provides filtered image results to the AI modules, detecting tumors and macroarchitecture features. A quality assessment process produces quality score outputs for tumors and macroarchitecture features. A report generator provides reports with one or more parameters to a user via an interface. More particularly, the report generator automatically creates a pathology report, having a written description and pictorial diagram relative to the gross images of the tissue integrating the outputs of the AI modules used to analyze the whole slide digital images.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies

Abstract

A tissue ablation system and method are provided. The system includes a catheter including a distal electrode tip having at least one tip electrode, at least one return electrode positionable independently of the tip electrode, and a voltage generator circuit electrically connected to the tip electrode and to the return electrode. The tip electrode and the return electrode include a dielectric or other non-conductive surface layer. The voltage generator circuit applies a voltage differential across the tip electrode and the return electrode such that the tip electrode and the return electrode are given opposite polarity. Tissue located between the tip electrode and the return electrode acts as a capacitive dielectric medium in which an electric field is present and is not dependent on current flow between the tip electrode and the return electrode, and the electric field induces electroporation of tissue cells in a vicinity of the distal electrode tip.

IPC Classes  ?

• A61B 18/14 - Probes or electrodes therefor
• A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
• A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques

Abstract

This invention provides a system for automation of a pathology process, which includes a processor having trained artificial intelligence (Al) modules operating in association therewith, adapted to receive image data from camera images of whole tissue acquired by a camera assembly and whole slide images (WSIs) of inked and segmented tissue samples. A mask produces image results for tissue with holes and free of holes, and a filter provides filtered image results to the Al modules, detecting tumors and macroarchitecture features. A quality assessment process produces quality score outputs for tumors and macroarchitecture features. A report generator provides reports with one or more parameters to a user via an interface. More particularly, the report generator automatically creates a pathology report, having a written description and pictorial diagram relative to the gross images of the tissue integrating the outputs of the Al modules used to analyze the whole slide digital images.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

Abstract

A system and method for creating a cavity with a drill assembly provides a powered drill shaft assembly having an articulating tip and a position sensor along the drill shaft; a drill motor assembly with a rotational motor, linear actuator, torque sensor, rotation sensor, electrical resistance sensor and a controller unit having a plurality of programs providing user interface and controlling the operation of the powered drill arrangement; a shroud for the drill shaft with a water port; and a computer software package that combines user specifications with sensor data to control activation and displacement of the drill with a user interface, controls the motor for rotational speed and drilling depth, and gives sensor status, and a display displaying status of a drilling procedure and an image from an imaging device, and that is programmable for a set of parameters for a drilling procedure.

IPC Classes  ?

• A61B 17/00 - Surgical instruments, devices or methods
• A61B 17/16 - Instruments for performing osteoclasisDrills or chisels for bonesTrepans