This disclosure provides genetically engineered organisms with genetic modifications that are useful for producing desirable alkaloids. This disclosure also provides methods of making genetically engineered organisms that can produce desirable alkaloids. The organisms described herein produce alkaloids in amounts beyond that produced from comparable wild-type organisms. In certain embodiments, the genetically engineered organisms are fungi from the Basidiomycota division.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Mushrooms Extracts for use in the manufacture of food Mushroom extracts and compositions for pharmaceutical, medicinal, therapeutic, and nutraceutical use
3.
Genetically modified organisms for producing psychotropic alkaloids
This disclosure provides genetically engineered organisms with genetic modifications that are useful for producing desirable alkaloids. This disclosure also provides methods of making genetically engineered organisms that can produce desirable alkaloids. The organisms described herein produce alkaloids in amounts beyond that produced from comparable wild-type organisms. In certain embodiments, the genetically engineered organisms are fungi from the Basidiomycota division.
This disclosure provides genetically engineered organisms with genetic modifications that are useful for producing desirable alkaloids. This disclosure also provides methods of making genetically engineered organisms that can produce desirable alkaloids. The organisms described herein produce alkaloids in amounts beyond that produced from comparable wild-type organisms. In certain embodiments, the genetically engineered organisms are fungi from the Basidiomycota division.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/80 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
5.
TARGETS AND PATHWAYS FOR THE PRODUCTION OF ALKALOIDAL COMPOUNDS
This disclosure relates generally to non-naturally organisms, as well as compositions and methods thereof, which host biosynthetic pathways that can produce novel or rare alkaloids, comprising an engineered fungal cell comprising a heterologous PsiL gene and methods of overexpressing a gene involved m psilocybin biosynthesis in a psilocybe protoplast. In some embodiments, the non-naturally occurring organism are fungi from division Basidiomycota.
This disclosure provides non-naturally occurring organisms with genetic modifications that are useful for producing desirable alkaloids. This disclosure also provides methods of making and analysing non-naturally occurring organisms that can produce desirable alkaloids. The organisms described herein produce alkaloids in amounts beyond that produced from comparable wild-type organisms. In certain embodiments, the genetically modified organisms are fungal cells of a mycelial mass from the Basidiomycota division.
Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psilocin compositions generated by the provided methods.
Provided herein are methods for modulating the cannabinoid biosynthesis pathway in plants. Also provided are cannabinoid compositions comprising rare cannabinoids, new cannabinoids, and variant cannabinoids generated by the provided methods.
C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
9.
GENETIC ENGINEERING OF FUNGI TO MODULATE TRYPTAMINE EXPRESSION
Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psilocin compositions generated by the provided methods.
Provided herein are compositions comprising genetically modified cells, organisms, or plants described herein or extracts and products thereof and methods for making and using the same. Also provided are therapeutics derived from genetically modified cells, organisms, or plants described herein or extracts and products thereof for use in preventing, treating, or stabilizing disease and conditions.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
31 - Agricultural products; live animals
Goods & Services
Extracts for use in the manufacture of food. Mushroom extracts and compositions for pharmaceutical,
medicinal, therapeutic, and nutraceutical use. Mushrooms.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
31 - Agricultural products; live animals
Goods & Services
(1) Mushroom extracts for use in the manufacture of food.
(2) Mushroom extracts and compositions for pharmaceutical, medicinal, therapeutic, and nutraceutical use for neurological and mood disorders.
(3) Genetically-modified edible mushrooms.
Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psi!ocin compositions generated by the provided methods.
