A composition in the form of microparticles primarily made up of: a) an inert core; b) a layer of active principle formed by spraying onto the inert core, and c) optionally, a second coating comprising one or more layers of pharmaceutically acceptable excipient(s) and/or drug(s). Said composition may be used to treat conditions resulting from excessive retention of water and/or electrolytes, cardiovascular disease, renovascular disease, diabetes, endothelial dysfunction, cirrhosis, preeclampsia, nephropathy, peripheral vascular disease and hypertension, among others.
A61K 31/549 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
The invention relates to novel solid forms of phosphodiesterase type 5 (PDE5) inhibitors, especially to complex co-crystals, and to the solvates and/or the polymorphs of same. Said substances can be used to produce a pharmaceutical composition containing same as the useful active ingredient. Said compounds can exhibit a constant storage stability.
The present invention relates to pharmaceutical combinations of two antiepileptic substances and also to combinations of an antiepileptic and B-complex vitamins, in which the antiepileptic substances are selected from pregabalin and oxcarbazepine, and the vitamins are selected from vitamin B and vitamin B12. The invention also relates to pharmaceutical compositions containing said combinations and to the use of said compositions for treating neuropathic pain (NP).
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 31/714 - Cobalamins, e.g. cyanocobalamin, vitamin B12
The invention relates to an oral pharmaceutical composition comprising the combination of an ibuprofen salt or S(+)-ibuprofen with L-arginine and/or the pharmaceutically acceptable salts thereof, and additionally pharmaceutically acceptable vehicles and/or excipients. The invention also relates to the method of producing the composition and to the use of said composition having synergic therapeutic activity, for treating moderate to severe inflammatory pain, fever and inflammation.
The invention relates to a pharmaceutical combination and composition, and in particular to a combination of an analgesic and an anti-inflammatory selected from Ketorolac and Meloxicam or Piroxicam, and pharmaceutically suitable vehicles or excipients. The invention also relates to a method for manufacturing a pharmaceutical composition and to the use of said composition in preparing a medication that can be used to treat pain and inflammation.
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
The invention relates to novel solid forms of fluoroquinolones, in particular to complex cocrystals and the solvates, hydrates and polymorphs thereof. These substances can be used to prepare a pharmaceutical composition containing same as an active ingredient, which can be used as an antibiotic. The compounds have a storage stability that is constant and above that of the salts or hydrates thereof.
C07D 215/56 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
The present application relates to the pharmaceutical field, especially the field of combination and pharmaceutical compositions that comprise a lipase inhibitor and a phytoalexin and pharmaceutically acceptable vehicles or excipients; the present invention also relates to the method for manufacturing compositions containing the combination and the use of said composition in the treatment of conditions of excess weight, obesity and related health problems.
C07C 39/21 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic part, with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
The present application relates to the pharmaceutical field, especially the field of combination and pharmaceutical compositions that comprise a lipase inhibitor and a phytoalexin and pharmaceutically acceptable vehicles or excipients; the present invention also relates to the method for manufacturing compositions containing the combination and the use of said composition in the treatment of conditions of excess weight, obesity and related health problems.
C07C 39/21 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic part, with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
The invention relates to pharmaceutical compositions in the form of tablets for oral administration, containing an active principle and pharmaceutically acceptable excipients. The tablets are characterised in that one part of the active principle is released immediately, while another part of the active principle is located in a polymer diffusion matrix system that allows the active principle to be released in a delayed manner.
The invention relates to a salt of a pyrimidin derivative of the acid (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamide)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic, to a method for preparing same and to the use thereof in formulating pharmaceutical formulations.
The invention relates to an oral pharmaceutical composition comprising the combination of an ibuprofen salt or S(+)-ibuprofen with L-arginine and/or the pharmaceutically acceptable salts thereof, and additionally pharmaceutically acceptable vehicles and/or excipients. The invention also relates to the method of producing the composition and to the use of said composition having synergic therapeutic acitvity, for treating moderate to severe inflammatory pain, fever and inflammation.
The present invention relates to a topical pharmaceutical composition that comprises the combination of an antimicrobial, a glucocorticoid, an antimycotic and pharmaceutically acceptable vehicles or excipients; the method for producing the composition and the use of said composition for treating localized dermatosis ailments.
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
The invention relates to a modified-release oral pharmaceutical composition in capsules with microspheres, containing loratadine, phenylephrine and pharmaceutically acceptable excipients. Said composition has immediate bioavailability, with plasmatic concentration values within the therapeutic window with a uniform, continuous release. The invention also relates to a method for the production of the composition and to the use thereof for treatment as a nasal decongestant and an antihistamine.
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
The present invention relates to a solid oral pharmaceutical composition comprisingfluconazole, tinidazole and clindamycin or a pharmaceutically acceptable salt thereof, whereinthe content of pharmaceutically acceptable excipients is significantly lower than the content ofthe active principles, the use of said composition for oral administration with therapeutic activityfor treating sexually transmitted infections.
The present invention relates to a solid oral pharmaceutical composition comprising fluconazole, tinidazole and clindamycin or a pharmaceutically acceptable salt thereof, wherein the content of pharmaceutically acceptable excipients is significantly lower than the content of the active principles, the use of said composition for oral administration with therapeutic activity for treating sexually transmitted infections.
ORAL GALENIC FORMULATION INCLUDING KETOROLAC AND B-COMPLEX VITAMINS, IN WHICH VITAMIN B6 IS IN AN OUTER LAYER SEPARATED FROM THE REST OF THE ACTIVE PRINCIPLES
The invention relates to a solid oral pharmaceutical composition combining ketorolac and B-complex consisting of inter alia thiamin, pyridoxine and cyanocobalamin (vitamins B1, B6 and B12 respectively) and/or the pharmaceutically acceptable salts thereof, as well as pharmaceutically acceptable excipients and/or vehicles. The invention also relates to the method for producing the composition and to the use of said composition having a synergistic therapeutic activity, indicated for the treatment of moderate to severe pain or neuralgias in different locations.
The present invention concerns a pharmaceutical composition in capsules with covered microspheres comprising the combination of amiodipine besylate and Pravastatine Sodium and pharmaceutically acceptable salts thereof, and in addtion pharmaceutically acceptable vehicles or excipients; also concerned is a method for production of the composition and the use of said composition for preparation of a medicine with synergistic therapeutic activity prescribed in the treatment of cardiovascular diseases such as high blood pressure and dislypidemia and comorbility thereof.
The invention relates to a modified release pharmaceutical composition in capsules with coated microsphere, combining two active ingredients with radically different plasmatic concentration times, namely a muscle relaxant (tizanidine) and a non-steroidal anti-inflammatory drug (meloxicam), pharmaceutically acceptable excipients or vehicles, as well as a method for producing the composition and the use of said combination for the preparation of a drug having a synergic therapeutic effect in the treatment of spasticity, disorders related to skeletal muscle and/or muscular ailments and moderate to severe pain in general.
A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
19.
PHARMACEUTICAL COMPOSITION THAT COMPRISES AN ANALGESIC AND VITAMINS
The present invention relates to pharmaceutical combinations of ketorolac salt and B complex, to methods for manufacturing said combinations and, in particular, to the synergistic combinations of ketorolac and B complex that are of use in the treatment of patients suffering moderate to severe pain and neuralgias in various locations.
patents
