Abstract

An apparatus for generating ions from sample material deposited on a sample carrier includes a chamber that keeps the sample material in a conditioned environment, an ablation device that locally ablates the deposited sample material and converts it to the gas phase, an energy input device that exposes the ablated sample material to an input energy burst, and an extraction device that extracts ions from the ablated sample material exposed to the input energy burst and transfers them to an ion processing apparatus, the ablation energy burst and/or input energy burst comprising a beam of coherent electromagnetic waves and the ablation device and/or the energy input device comprising a beam distributor that provides a plurality of optically parallel beam paths which each have a frequency multiplier unit and are combined again, wherein all frequency multiplier units emit a uniform output frequency. Likewise disclosed is a corresponding method.

IPC Classes  ?

• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Goods & Services

Coating machines; coating machines for coating samples or sample carriers by means of sublimation and resublimation, in particular for coating samples or sample carriers with MALDI matrix material. Apparatus for scientific purposes; mass spectrometers, in particular MALDI-TOF mass spectrometers; devices for sample preparation, in particular devices for sample preparation for mass spectrometry, in particular for MALDI-TOF mass spectrometry; apparatus for coating samples or sample carriers by means of sublimation and resublimation, in particular for coating samples or sample carriers with MALDI matrix material. Apparatus for medical purposes; diagnostic apparatus for medical use; mass spectrometers for medical purposes, in particular MALDI-TOF mass spectrometers; devices for sample preparation for medical purposes, in particular devices for sample preparation for mass spectrometry, in particular for MALDI-TOF mass spectrometry; apparatus for coating samples or sample carriers for medical purposes by means of sublimation and resublimation, in particular for coating samples or sample carriers with MALDI matrix material.

Goods & Services

Computer software and computer programs for processing, evaluating and displaying data obtained from an analytical and scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for processing data obtained from an analytical and scientific instrument, namely spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for searching Omics data in real-time, in particular spectrometric proteomics data, lipidomics data, metabolomics data and the like; Computer software and computer programs for operating an analytical and scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Analytical and scientific instruments, namely spectrometers, in particular mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers. Medical and veterinary diagnostic instruments, in particular mass spectrometers, combined chromatograph mass spectrometers.

Abstract

The invention relates to a method for separating ions and a trapped ion mobility separator. The trapped ion mobility separator comprises an ion guide extending in a closed loop which contains a gas substantially at rest through which ions pass. An axial force acting on the ions is provided, being caused by an electric field barrier providing an electric field gradient that moves around the ion guide, and having an effect on the movement of the ions that is dependent on ion mobility. At least one operating parameter of the trapped ion mobility separator, which has an impact on the mobility separation, is varied as a function of time, so that the ions are pushed controlled along the moving electric field barrier towards a high potential end of the electric field barrier, wherein the ions are ejected laterally from the ion guide before slipping over said electric field barrier.

IPC Classes  ?

• H01J 49/06 - Electron- or ion-optical arrangements
• G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures

Abstract

The disclosure relates to producing and using a machine-learned or trained algorithm, such as resulting from (supervised) training a multi-layered or convolutional neural network using mass-curated training spectra, for mass recalibration of mass spectrometry data, in particular applied to mass spectrometry data which are based on matrix-assisted laser desorption/ionization (MALDI) as ionization mechanism, further in particular applied to mass spectrometry imaging (MSI) data, and further in particular including subjecting the mass spectrometry data to mass defect analysis, such as Kendrick mass defect analysis. In so doing, the quality of mass spectrometry data can be improved in a timely manner.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Goods & Services

Reagents for scientific purposes; reagents for use in scientific apparatus for chemical or biological analysis, in particular reagents for sample preparation for mass spectrometers or MALDI-TOF mass spectrometers; reagents for analytical purposes [other than for medical or veterinary purposes]; reagents for analytical purposes for the detection of biological material for research use for non-medical, non-clinical and non-veterinary diagnostics; reagents for analytical purposes, in particular reagents for sample preparation, for the detection and/or identification of microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, for research use for non-medical, non-clinical and non-veterinary diagnostics; chemical-biological test kits, consisting of reagents for use in analytical tests, in particular matrix solutions, their components and cell disruption solutions, for the detection and/or identification of microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, for research use for non-medical, non-clinical and non-veterinary diagnostics; chemical reagents for use in diagnostic tests, other than for medical or veterinary use; reagents for use in analytical tests [other than for medical or veterinary purposes]. Reagents and media for medical and veterinary diagnostic purposes; reagents for medical and veterinary diagnostic purposes, namely reagents for sample preparation and/or for use with analyzers, in particular reagents for sample preparation for mass spectrometers or MALDI-TOF mass spectrometers; reagents and media for medical and veterinary diagnostic purposes, in particular reagents for sample preparation used for the detection of infections, which break down microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, of a biological sample and/or prepare them for mass spectrometric analysis; diagnostic test kits, consisting of medical diagnostic reagents and sample preparation procedures, for testing biological samples for the detection of infections in medical, clinical and veterinary diagnostics; diagnostic test kits consisting of medical diagnostic reagents, in particular matrix solutions, their components and cell disruption solutions, for testing biological samples for use in the detection of infections, which break down microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, of a biological sample and/or prepare them for mass spectrometric analysis. Laboratory apparatus, other than for medical use; laboratory apparatus, other than for medical use, for sampling, application and transfer of microbial and non-microbial cells or cell components, including bacteria, yeasts, fungi, particles including virions. Medical apparatus; apparatus for carrying-out diagnostic tests for medical purposes; laboratory apparatus for medical use; laboratory apparatus for medical use for the collection, application and transfer of microbial and non-microbial cells or cell components, including bacteria, yeasts, fungi, particles including virions.

Goods & Services

Reagents for scientific purposes; media for cell culture for use in non-medical research laboratories; buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media; media for use in separation techniques [not medical], in particular extraction media; reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media; chemical-biological test kits for detecting sepsis for scientific purposes; reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use for non-medical, non-clinical and non-veterinary diagnostics; reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and parts of these cells and particles, from a liquid culture. Reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media; reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media, for use with detecting sepsis; diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, for medical, clinical and veterinary diagnostics; reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostics media, for use with detecting sepsis, and diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and part of these cells and particles, from a liquid culture, including a body fluid culture, in particular a blood culture. Laboratory apparatus and instruments [other than for medical use]; laboratory apparatus and instruments, namely apparatus and equipment for taking, processing and/or preparation of biological samples from a vessel for analytical purposes, in particular a fully or partially automated blood culture sampling and processing station for taking blood culture samples from blood culture bottles and processing and preparing the samples for further mass spectrometric analysis with the purpose of identification of microorganism in the samples and/or a sepsis; computer programs and computer software for controlling laboratory instruments; computer programs and computer software for controlling an apparatus for taking, preparation and processing of samples from a vessel for scientific purposes, in particular blood culture samples, e.g. for the analysis by mass spectrometry and for analyzing mass spectra data, and/or for identifying microorganisms including bacteria, yeasts and fungi, and particles including virions in a liquid culture from biological, industrial and food samples.

Goods & Services

Reagents for scientific purposes; media for cell culture for use in non-medical research laboratories; buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media; media for use in separation techniques [not medical], in particular extraction media; reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media; chemical-biological test kits for detecting sepsis for scientific purposes; reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use for non-medical, non-clinical and non-veterinary diagnostics; reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and parts of these cells and particles, from a liquid culture. Reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media; reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media, for use with detecting sepsis; diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, for medical, clinical and veterinary diagnostics; reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostics media, for use with detecting sepsis, and diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and part of these cells and particles, from a liquid culture, including a body fluid culture, in particular a blood culture. Laboratory apparatus and instruments [other than for medical use]; laboratory apparatus and instruments, namely apparatus and equipment for taking, processing and/or preparation of biological samples from a vessel for analytical purposes, in particular a fully or partially automated blood culture sampling and processing station for taking blood culture samples from blood culture bottles and processing and preparing the samples for further mass spectrometric analysis with the purpose of identification of microorganism in the samples and/or a sepsis; computer programs and computer software for controlling laboratory instruments; computer programs and computer software for controlling an apparatus for taking, preparation and processing of samples from a vessel for scientific purposes, in particular blood culture samples, e.g. for the analysis by mass spectrometry and for analyzing mass spectra data, and/or for identifying microorganisms including bacteria, yeasts and fungi, and particles including virions in a liquid culture from biological, industrial and food samples.

Goods & Services

Reagents for scientific purposes; reagents for use in scientific apparatus for chemical or biological analysis, in particular reagents for sample preparation for mass spectrometers or MALDI-TOF mass spectrometers; reagents for analytical purposes [other than for medical or veterinary purposes]; reagents for analytical purposes for the detection of biological material for research use for non-medical, non-clinical and non-veterinary diagnostics; reagents for analytical purposes, in particular reagents for sample preparation, for the detection and/or identification of microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, for research use for non-medical, non-clinical and non-veterinary diagnostics; chemical-biological test kits, consisting of reagents for use in analytical tests, in particular matrix solutions, their components and cell disruption solutions, for the detection and/or identification of microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, for research use for non-medical, non-clinical and non-veterinary diagnostics; chemical reagents for use in diagnostic tests, other than for medical or veterinary use; reagents for use in analytical tests [other than for medical or veterinary purposes]. Reagents and media for medical and veterinary diagnostic purposes; reagents for medical and veterinary diagnostic purposes, namely reagents for sample preparation and/or for use with analyzers, in particular reagents for sample preparation for mass spectrometers or MALDI-TOF mass spectrometers; reagents and media for medical and veterinary diagnostic purposes, in particular reagents for sample preparation used for the detection of infections, which break down microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, of a biological sample and/or prepare them for mass spectrometric analysis; diagnostic test kits, consisting of medical diagnostic reagents and sample preparation procedures, for testing biological samples for the detection of infections in medical, clinical and veterinary diagnostics; diagnostic test kits consisting of medical diagnostic reagents, in particular matrix solutions, their components and cell disruption solutions, for testing biological samples for use in the detection of infections, which break down microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, of a biological sample and/or prepare them for mass spectrometric analysis. Laboratory apparatus, other than for medical use; laboratory apparatus, other than for medical use, for sampling, application and transfer of microbial and non-microbial cells or cell components, including bacteria, yeasts, fungi, particles including virions. Medical apparatus; apparatus for carrying-out diagnostic tests for medical purposes; laboratory apparatus for medical use; laboratory apparatus for medical use for the collection, application and transfer of microbial and non-microbial cells or cell components, including bacteria, yeasts, fungi, particles including virions.

Goods & Services

Computer software and computer programs for laboratory apparatus, in particular for spectrometers; computer software and computer programs for processing, evaluating and displaying measurement data from a laboratory apparatus, in particular from a spectrometer; Computer software and computer programs for processing, evaluating and displaying data obtained from an analytical or scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for processing data obtained from an analytical or scientific instrument, namely spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for searching Omics data in real-time, in particular spectrometric proteomics data, lipidomics data, metabolomics data and the like; Computer software and computer programs for operating an analytical or scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Analytical and scientific instruments, namely spectrometers, in particular mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers; Laboratory apparatus and instruments other than for medical use, in particular spectrometers Medical and veterinary diagnostic instruments and apparatus, in particular mass spectrometers and combined chromatograph mass spectrometers.

Goods & Services

Computer software and computer programs for laboratory apparatus, in particular for spectrometers; computer software and computer programs for processing, evaluating and displaying measurement data from a laboratory apparatus, in particular from a spectrometer; Computer software and computer programs for processing, evaluating and displaying data obtained from an analytical or scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for processing data obtained from an analytical or scientific instrument, namely spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for searching Omics data in real-time, in particular spec-trometric proteomics data, lipidomics data, metabolomics data and the like; Computer software and computer programs for operating an analytical or scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Analytical and scientific instruments, namely spectrometers, in particular mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers.; Laboratory apparatus and instruments other than for medical use, in particular spectrometers Medical and veterinary diagnostic instruments and apparatus, in particular mass spectrometers and combined chromatograph mass spectrometers.

Abstract

The invention relates to methods for the analysis of sample material which is arranged on a sample carrier, comprising: - providing the sample carrier with sample material, - exciting fluorescent light emission from the sample material, - detecting emitted fluorescent light, - determining location data for the sample material along a z axis which is substantially perpendicular to a plane of the sample carrier, using the detected fluorescent light, - making a focus plane, object plane and/or image plane of an imaging optical assembly, which is used during scanning of the sample material, substantially congruent with the sample material using the determined location data, and - ion-spectrometrically analysing the sample material. The invention also relates to devices for carrying out such methods.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• G01N 21/64 - FluorescencePhosphorescence

Goods & Services

Reagents for scientific purposes; Media for cell culture for use in non-medical research laboratories; Buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media; Media for use in separation techniques [not medical], in particular extraction media; Reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media; Chemical-biological test kits for detecting sepsis for scientific purposes; Reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use for non-medical, non-clinical and non-veterinary diagnostics; Reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and parts of these cells and particles, from a liquid culture Reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media; Reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media, for use with detecting sepsis; Diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, for medical, clinical and veterinary diagnostics; Reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostics media, for use with detecting sepsis, and diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and part of these cells and particles, from a liquid culture, including a body fluid culture, in particular a blood culture Laboratory apparatus and instruments [other than for medical use]; Laboratory apparatus and instruments, namely apparatus and equipment for taking, processing and/or preparation of biological samples from a vessel for analytical purposes, in particular a fully or partially automated blood culture sampling and processing station for taking blood culture samples from blood culture bottles and processing and preparing the samples for further mass spectrometric analysis with the purpose of identification of microorganism in the samples and/or a sepsis; Computer programs and computer software for controlling laboratory instruments; Computer programs and computer software for controlling an apparatus for taking, preparation and processing of samples from a vessel for scientific purposes, in particular blood culture samples, e;g; For the analysis by mass spectrometry and for analyzing mass spectra data, and/or for identifying microorganisms including bacteria, yeasts and fungi, and particles including virions in a liquid culture from biological, industrial and food samples

Goods & Services

Reagents for scientific purposes; Media for cell culture for use in non-medical research laboratories; Buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media; Media for use in separation techniques [not medical], in particular extraction media; Reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media; Chemical-biological test kits for detecting sepsis for scientific purposes; Reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use for non-medical, non-clinical and non-veterinary diagnostics; Reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and parts of these cells and particles, from a liquid culture Reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media; Reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media, for use with detecting sepsis; Diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, for medical, clinical and veterinary diagnostics; Reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostics media, for use with detecting sepsis, and diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and part of these cells and particles, from a liquid culture, including a body fluid culture, in particular a blood culture Laboratory apparatus and instruments [other than for medical use]; Laboratory apparatus and instruments, namely apparatus and equipment for taking, processing and/or preparation of biological samples from a vessel for analytical purposes, in particular a fully or partially automated blood culture sampling and processing station for taking blood culture samples from blood culture bottles and processing and preparing the samples for further mass spectrometric analysis with the purpose of identification of microorganism in the samples and/or a sepsis; Computer programs and computer software for controlling laboratory instruments; Computer programs and computer software for controlling an apparatus for taking, preparation and processing of samples from a vessel for scientific purposes, in particular blood culture samples, e;g; For the analysis by mass spectrometry and for analyzing mass spectra data, and/or for identifying microorganisms including bacteria, yeasts and fungi, and particles including virions in a liquid culture from biological, industrial and food samples

Abstract

The invention relates to a method to evaluate mass spectrometry data for the analysis of peptides from biological samples, particularly MALDI-TOF mass spectrometry data, comprising the steps of: providing expected mass defects; determining measured mass defects, i.e. the mass defects resulting from the mass spectrometry data; and comparing the measured mass defects with the expected mass defects.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

The present disclosure relates to an apparatus for transmitting gaseous ionic sample material for subsequent analysis, in particular mass analysis, comprising: a first vacuum chamber through which ionic sample material is guided, the first vacuum chamber being kept in a first pressure range, a second downstream vacuum chamber through which ionic sample material is guided, the second downstream vacuum chamber being kept in a second pressure range which is substantially higher than the first pressure range, and a first gas inlet assembly located substantially at the second vacuum chamber and designed and configured to introduce gaseous matter, which does not originate from the first vacuum chamber, directedly into the second vacuum chamber. The present disclosure relates further to a corresponding method for transmitting gaseous ionic sample material for subsequent analysis, in particular mass analysis.

IPC Classes  ?

• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• G01N 27/622 - Ion mobility spectrometry
• H01J 49/06 - Electron- or ion-optical arrangements

Goods & Services

Mass spectrometers, particularly time-of-flight mass spectrometers; software used to process mass spectra and to identify microorganisms, like bacteria, yeasts, viruses or fungi, in biological, industrial or food samples. Apparatus and instruments for medical and veterinary diagnosis, particularly mass spectrometers used in medical and clinical applications for identifying microorganisms, like bacteria, yeasts, viruses or fungi.

Goods & Services

Mass spectrometers, particularly time-of-flight mass spectrometers; software used to process mass spectra and to identify microorganisms, like bacteria, yeasts, viruses or fungi, in biological, industrial or food samples. Apparatus and instruments for medical; apparatus and instruments for veterinary diagnosis; analyzers for bacterial identification for medical purposes; diagnostic test equipment for finding abnormal viral proteins; medical diagnostic equipment for virus detection.

Goods & Services

Mass spectrometers, particularly time-of-flight mass spectrometers; software used to process mass spectra and to identify microorganisms, like bacteria, yeasts, viruses or fungi, in biological, industrial or food samples. Apparatus and instruments for medical and veterinary diagnosis, particularly mass spectrometers used in medical and clinical applications for identifying microorganisms, like bacteria, yeasts, viruses or fungi.

Goods & Services

Reagents for scientific purposes; reagents for use in scientific apparatus for chemical or biological analysis, in particular reagents for sample preparation for mass spectrometers or MALDI-TOF mass spectrometers; reagents for analytical purposes [other than for medical or veterinary purposes]; reagents for analytical purposes for the detection of biological material for research use for non-medical, non-clinical and non-veterinary diagnostics; reagents for analytical purposes, in particular reagents for sample preparation, for the detection and/or identification of microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, for research use for non-medical, non-clinical and non-veterinary diagnostics; chemical-biological test kits, consisting of reagents for use in analytical tests, in particular matrix solutions, their components and cell disruption solutions, for the detection and/or identification of microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, for research use for non-medical, non-clinical and non-veterinary diagnostics; chemical reagents for use in diagnostic tests, other than for medical or veterinary use; reagents for use in analytical tests [other than for medical or veterinary purposes]. Reagents and media for medical and veterinary diagnostic purposes; reagents for medical and veterinary diagnostic purposes, namely reagents for sample preparation and/or for use with analyzers, in particular reagents for sample preparation for mass spectrometers or MALDI-TOF mass spectrometers; reagents and media for medical and veterinary diagnostic purposes, in particular reagents for sample preparation used for the detection of infections, which break down microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, of a biological sample and/or prepare them for mass spectrometric analysis; diagnostic test kits, consisting of medical diagnostic reagents and sample preparation procedures, for testing biological samples for the detection of infections in medical, clinical and veterinary diagnostics; diagnostic test kits consisting of medical diagnostic reagents, in particular matrix solutions, their components and cell disruption solutions, for testing biological samples for use in the detection of infections, which break down microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, of a biological sample and/or prepare them for mass spectrometric analysis. Laboratory apparatus, other than for medical use; laboratory apparatus, other than for medical use, for sampling, application and transfer of microbial and non-microbial cells or cell components, including bacteria, yeasts, fungi, particles including virions. Medical apparatus; apparatus for carrying-out diagnostic tests for medical purposes; laboratory apparatus for medical use; laboratory apparatus for medical use for the collection, application and transfer of microbial and non-microbial cells or cell components, including bacteria, yeasts, fungi, particles including virions.

Abstract

The disclosure relates generally to analytical measurement and, more specifically, to the use of ion spectrometry, including mass analysis, for the quantitation and chemical characterization (e.g., identification) of biological or synthetic materials using two different ion spectrometric measurement cycles. The methods may be employed fruitfully in particular with analyte molecules of low molecular weight, such as metabolites.

IPC Classes  ?

• G01N 30/72 - Mass spectrometers
• G01N 30/02 - Column chromatography
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• H01J 49/40 - Time-of-flight spectrometers
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Abstract

The disclosure relates to devices and methods for the spectrometric analysis of sample material located on a sample support, and in particular on a flat sample support plate, using axial time-of-flight analysis. One operating mode of the devices and methods comprises an adjustment of the pulse focal position for the abrupt ablation and/or abrupt desorption of sample material in a z-direction that is perpendicular to a tangential plane at the location of ablation and/or desorption at the sample support, and the selection of a suitable setting for an acceleration with time lag of the ablated and/or desorbed and ionized sample material onto a flight path. It can be particularly advantageous to use these devices and methods in mass spectrometry imaging (MSI). The devices and methods can, in particular, be used with laser desorption/ionization (LDI) and specifically matrix-assisted laser desorption/ionization (MALDI).

IPC Classes  ?

• H01J 49/40 - Time-of-flight spectrometers
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Goods & Services

Computer software and computer programs for laboratory apparatus, in particular for spectrometers; computer software and computer programs for processing, evaluating and displaying measurement data from a laboratory apparatus, in particular from a spectrometer; Computer software and computer programs for processing, evaluating and displaying data obtained from an analytical or scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for processing data obtained from an analytical or scientific instrument, namely spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for searching Omics data in real-time, in particular spectrometric proteomics data, lipidomics data, metabolomics data and the like; Computer software and computer programs for operating an analytical or scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Laboratory apparatus and instruments [other than for medical use], in particular spectrometers; Analytical and scientific instruments, namely spectrometers, in particular mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers. Medical and veterinary diagnostic instruments and apparatus, in particular mass spectrometers and combined chromatograph mass spectrometers.

Goods & Services

Computer software and computer programs for laboratory apparatus, in particular for spectrometers; computer software and computer programs for processing, evaluating and displaying measurement data from a laboratory apparatus, in particular from a spectrometer; Computer software and computer programs for processing, evaluating and displaying data obtained from an analytical or scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for processing data obtained from an analytical or scientific instrument, namely spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for searching Omics data in real-time, in particular spectrometric proteomics data, lipidomics data, metabolomics data and the like; Computer software and computer programs for operating an analytical or scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Laboratory apparatus and instruments [other than for medical use], in particular spectrometers; Analytical and scientific instruments, namely spectrometers, in particular mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers. Medical and veterinary diagnostic instruments and apparatus, in particular mass spectrometers and combined chromatograph mass spectrometers.

Goods & Services

reagents for scientific purposes; media for cell culture for use in non-medical research laboratories; buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media; media for use in separation techniques [not medical], in particular extraction media; reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media; chemical-biological test kits for detecting sepsis for scientific purposes; reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use for non-medical, non-clinical and non-veterinary diagnostics; reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and parts of these cells and particles, from a liquid culture. reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media; reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media, for use with detecting sepsis; diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, for medical, clinical and veterinary diagnostics; reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostics media, for use with detecting sepsis, and diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and part of these cells and particles, from a liquid culture, including a body fluid culture, in particular a blood culture. laboratory apparatus and instruments [other than for medical use]; laboratory apparatus and instruments, namely apparatus and equipment for taking, processing and/or preparation of biological samples from a vessel for analytical purposes, in particular a fully or partially automated blood culture sampling and processing station for taking blood culture samples from blood culture bottles and processing and preparing the samples for further mass spectrometric analysis with the purpose of identification of microorganism in the samples and/or a sepsis; Computer programs and computer software for controlling laboratory instruments; Computer programs and computer software for controlling an apparatus for taking, preparation and processing of samples from a vessel for scientific purposes, in particular blood culture samples, e.g. for the analysis by mass spectrometry and for analyzing mass spectra data, and/or for identifying microorganisms including bacteria, yeasts and fungi, and particles including virions in a liquid culture from biological, industrial and food samples.

Goods & Services

reagents for scientific purposes; media for cell culture for use in non-medical research laboratories; buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media; media for use in separation techniques [not medical], in particular extraction media; reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media; chemical-biological test kits for detecting sepsis for scientific purposes; reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use for non-medical, non-clinical and non-veterinary diagnostics; reagents for scientific purposes, media for cell culture for use in non-medical research laboratories, buffer solutions for scientific purposes, in particular lysis buffer media and washing buffer media, media for use in separation techniques [not medical], in particular extraction media, reagents for analytical purposes [other than for medical or veterinary purposes], in particular matrix substance media, and chemical-biological test kits, for detecting sepsis for research use, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and parts of these cells and particles, from a liquid culture. reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media; reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostic media, for use with detecting sepsis; diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, for medical, clinical and veterinary diagnostics; reagents and media for medical and veterinary diagnostic purposes, in particular culture media, extraction media and diagnostics media, for use with detecting sepsis, and diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood or blood culture samples for use in detecting sepsis, that separate and process microbial and non-microbial cells, including bacteria, yeasts, fungi, particles including virions, and part of these cells and particles, from a liquid culture, including a body fluid culture, in particular a blood culture. laboratory apparatus and instruments [other than for medical use]; laboratory apparatus and instruments, namely apparatus and equipment for taking, processing and/or preparation of biological samples from a vessel for analytical purposes, in particular a fully or partially automated blood culture sampling and processing station for taking blood culture samples from blood culture bottles and processing and preparing the samples for further mass spectrometric analysis with the purpose of identification of microorganism in the samples and/or a sepsis; Computer programs and computer software for controlling laboratory instruments; Computer programs and computer software for controlling an apparatus for taking, preparation and processing of samples from a vessel for scientific purposes, in particular blood culture samples, e.g. for the analysis by mass spectrometry and for analyzing mass spectra data, and/or for identifying microorganisms including bacteria, yeasts and fungi, and particles including virions in a liquid culture from biological, industrial and food samples.

Abstract

The invention relates to a method for the preparation of living, microbial samples and microorganisms for subsequent mass spectrometric measurement and evaluation. Findings which can be derived from such a measurement can particularly serve the faster identification of microorganisms in the microbial sample according to species/subspecies and/or the fast determination of resistance/sensitivity of the microorganisms to antimicrobial substances and/or the further characterization of microorganisms, for example in respect of pathogenicity, virulence and metabolism. According to a preferred embodiment of the invention, the preparation particularly takes place directly on a mass spectrometric sample support.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/18 - Testing for antimicrobial activity of a material

Abstract

x,y). The invention also relates to methods for acquiring and processing ion-spectrometric measurement signal data, and ion mobility-mass spectrometers.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Abstract

Devices and methods for the spectrometric analysis of sample material located in an ablation area on a sample support are disclosed, including a mode of operation which comprises: (i) locating the ablation area on the sample support and determining an ablation area dimension between opposing boundaries of the ablation area; (ii) beam-assisted sampling from the ablation area, e.g., using MALDI, and mass analyzing, e.g., using an IMS-QoTOF analyzer, the ablated and/or desorbed and ionized sample material, wherein a beam impingement region, which is selected no larger than the dimension of the ablation area, is moved within the boundaries of the ablation area while performing ablation and/or desorption operations and an extension of the beam impingement region is changed at least once; and (iii) combining the molecular information obtained by the ablation and/or desorption operations from the ablation area into a single spectral dataset.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Abstract

Disclosed are methods and devices for desorbing and ionizing of sample material which is deposited on a sample support, which methods and devices use a post-desorption ionization modality with dynamic spatial alignment. Principles of the disclosure may be used in imaging ion spectrometry, for example, particularly in imaging ion spectrometry with ion generation using matrix-assisted laser desorption and ionization (MALDI).

IPC Classes  ?

• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components

Abstract

The invention relates to a method and a device for monitoring and controlling the performance of an ion source, said method comprising: (a) using a laser to ionise a control sample, the composition of which is substantially known and which is sampled before, in parallel with, or after an analytical sample; (b) generating items of control sample spectral data from the ionised control sample in an ion analyser connected to the ion source; (c) repeating steps (a) and (b) over a plurality of control samples in order to collect a plurality of items of control sample spectral data and analyse them such that items of spectral data of individual control samples have a low weight and a performance trend appears in the analysis; (d) if the performance trend enters a range outside a predefined performance interval, adjusting an operating parameter of the laser of the ion source in order to adjust the laser to conform to the interval; and (e) repeating steps (a) to (d) in order to continuously monitor and control the ion source.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• G01N 27/626 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using heat to ionise a gas

Abstract

The invention relates to a device for multimodal analysis of sample material, e.g. from a tissue, which acquires molecule image data from the sample material in a spatially resolved fashion, e.g. using MALDI time-of-flight mass analyzer, records light-microscope image data from the sample material in a spatially resolved fashion and combines both with improved accuracy to form spatially resolved co-registered full image data.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• G01N 21/59 - Transmissivity

Goods & Services

Computer programs and computer software for acquiring, processing, evaluating and displaying data from liquid and gas chromatographs, mass spectrometers, ion mobility spectrometers, and combinations of the afore-mentioned, in particular measurement data of biological samples and biomolecules; computer programs and computer software for collisional cross section (CCS)-aware acquiring, processing, evaluating and displaying of analytical data; computer programs and computer software for CCS-enabled searching of databases, in particular for identifying biomolecules.

Abstract

The invention relates to a method for determining the cytotoxic effect of an analytical sample on animal cells, including human cells. The method comprises (a) a sample provision step in which a mass spectrometric sample comprising animal cells, nutrient medium, and the analytical sample potentially having a cytotoxic factor is prepared on at least one sample spot of a mass spectrometric sample support; (b) a cultivation step in which the mass spectrometric sample is incubated on the sample spot of the mass spectrometric sample support in a cultivation device; (c) a liquid removal step in which residual liquid of the mass spectrometric sample is removed from the sample spot; (d) a measuring step in which spatially resolved mass spectra are recorded at a plurality of measuring positions in at least a partial area of the sample spot by means of a spatial resolution mass spectrometer, wherein, when a matrix-based spatial resolution mass spectrometer is used, prior to the recording of the spatially resolved mass spectra in the measuring step, a preparation of the sample spot is carried out in a preceding sample preparation step by the spatially dispersed application of a matrix to at least the one partial area of the sample spot; (e) a first evaluation step in which each spatially resolved mass spectrum is analyzed for the presence of a cell-specific mass spectrometric signature for the animal cells and a cell presence value is assigned to each measuring position; (f) a second evaluation step in which a degree of coverage by animal cells is determined for at least the partial area of the sample spot from the cell presence values of the measuring positions; (g) and/or a third evaluation step in which a proliferation capability is derived from the determined degree of coverage; (h) a fourth evaluation step in which the cytotoxic effect of the analytical sample on the animal cells is derived indirectly or directly from the determined degree of coverage of the second evaluation step, wherein for this purpose the cytotoxic effect of the analytical sample on the animal cells is derived from the result of at least one of the two steps: second evaluation step and/or third evaluation step.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Goods & Services

Downloadable computer programs and downloadable computer software for acquiring, processing, evaluating and displaying data from liquid and gas chromatographs, mass spectrometers, ion mobility spectrometers, and combinations of the afore-mentioned, in particular measurement data of biological samples and biomolecules; downloadable computer programs and downloadable computer software for collisional cross section (CCS)-aware acquiring, processing, evaluating and displaying of analytical data; downloadable computer programs and downloadable computer software for CCS-enabled searching of databases, in particular for identifying biomolecules

Goods & Services

Downloadable computer software and preinstalled computer software sold as a component of an acquisition computer, and downloadable computer programs and preinstalled computer programs sold as a component of an acquisition computer, all for instrument control of ion mobility spectrometers, mass spectrometers, and combined ion mobility-mass spectrometers, including combined trapped ion mobility-time of flight mass spectrometers, combined trapped ion mobility-Fourier transform ion cyclotron resonance mass spectrometers, combined trapped ion mobility-ion trap mass spectrometers, and combined trapped ion mobility-quadrupole mass spectrometers; Downloadable computer software and preinstalled computer software sold as a component of an acquisition computer, and downloadable computer programs and preinstalled computer programs sold as a component of an acquisition computer, all for acquiring, processing and presenting data from ion mobility spectrometers, mass spectrometers, and combined ion mobility mass spectrometers, including combined trapped ion mobility-time of flight mass spectrometers, combined trapped ion mobility-Fourier transform ion cyclotron resonance mass spectrometers, combined trapped ion mobility-ion trap mass spectrometers, and combined trapped ion mobility-quadrupole mass spectrometers; Pre-recorded data carriers carrying recorded software for instrument control of ion mobility spectrometers, mass spectrometers, and combined ion mobility-mass spectrometers, including combined trapped ion mobility-time of flight mass spectrometers, combined trapped ion mobility-Fourier transform ion cyclotron resonance mass spectrometers, combined trapped ion mobility-ion trap mass spectrometers, and combined trapped ion mobility-quadrupole mass spectrometers; Prerecorded data carriers carrying recorded software for acquiring, processing and presenting data from ion mobility spectrometers, mass spectrometers, and combined ion mobility mass spectrometers, including combined trapped ion mobility-time of flight mass spectrometers, combined trapped ion mobility-Fourier transform ion cyclotron resonance mass spectrometers, combined trapped ion mobility-ion trap mass spectrometers, and combined trapped ion mobility-quadrupole mass spectrometers; all aforementioned goods for research purposes, and not for the medical, dental or veterinary fields and their applications, and not for the field of non-destructive testing and its applications

Goods & Services

Computer software and computer programs for processing, evaluating and displaying data obtained from an analytical and scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; computer software and computer programs for processing data obtained from an analytical and scientific instrument, namely spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; computer software and computer programs for searching Omics data in real-time, in particular spectrometric proteomics data, lipidomics data, metabolomics data and the like; computer software and computer programs for operating an analytical and scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; analytical and scientific instruments, namely spectrometers, in particular mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers. Medical and veterinary diagnostic instruments, in particular mass spectrometers, combined chromatograph mass spectrometers.

Goods & Services

Downloadable computer software and downloadable computer programs for processing, evaluating and displaying data obtained from an analytical and scientific instrument, namely, a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; downloadable computer software and downloadable computer programs for processing data obtained from an analytical and scientific instrument, namely, spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; downloadable computer software and downloadable computer programs for searching Omics data in real-time, in particular spectrometric proteomics data, lipidomics data, metabolomics data and the like; downloadable computer software and downloadable computer programs for operating an analytical and scientific instrument, namely, a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; scientific apparatus, namely, spectrometers being mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers Medical and veterinary diagnostic instruments in the nature of mass spectrometers and combined chromatograph mass spectrometers for testing for viruses, bacteria, fungi and yeasts

Abstract

The invention relates to a method for the spectrometric characterization of microorganisms, comprising: providing a test microorganism; acquiring spectrometric measurement data from the test microorganism under potential exposure to variance that is not based on taxonomic classification; selecting a classifier which is trained to determine the identity of a microorganism on a second taxonomic level; and applying the classifier to the measurement data in order to determine the identity of the test microorganism on the second taxonomic level, wherein the classifier is variance-conditioned in such a way that it largely or completely masks out the effect of variance in the characterization of the test microorganism on the second taxonomic level.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

Goods & Services

Computer programs and computer software for acquiring, processing, evaluating and displaying data from liquid and gas chromatographs, mass spectrometers, ion mobility spectrometers, and combinations of the afore-mentioned, in particular measurement data of biological samples and biomolecules; Computer programs and computer software for collisional cross section (CCS) -aware acquiring, processing, evaluating and displaying of analytical data; Computer programs and computer software for CCS-enabled searching of databases, in particular for identifying biomolecules..

Goods & Services

Computer software and computer programs for instrument control of ion mobility spectrometers, mass spectrometers, and combined ion mobility-mass spectrometers, including combined trapped ion mobility-time of flight mass spectrometers, combined trapped ion mobility-Fourier transform ion cyclotron resonance mass spectrometers, combined trapped ion mobility-ion trap mass spectrometers, and combined trapped ion mobility-quadrupole mass spectrometers; Computer software and computer programs for acquiring, processing and presenting data from ion mobility spectrometers, mass spectrometers, and combined ion mobility-mass spectrometers, including combined trapped ion mobility-time of flight mass spectrometers, combined trapped ion mobility-Fourier transform ion cyclotron resonance mass spectrometers, combined trapped ion mobility-ion trap mass spectrometers, and combined trapped ion mobility-quadrupole mass spectrometers; Pre-recorded data carriers carrying the aforementioned software; all aforementioned goods for research purposes, and not for the medical, dental or veterinary fields and their applications, and not for the field of non-destructive testing and its applications.

Abstract

The invention relates to a method to evaluate mass spectrometry data for the analysis of peptides from biological samples, particularly MALDI-TOF mass spectrometry data, comprising the steps of: providing expected mass defects; determining measured mass defects, i.e. the mass defects resulting from the mass spectrometry data; and comparing the measured mass defects with the expected mass defects.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

The invention relates to methods for spectrometric characterization of a test cell substrate. The characterization comprises taxonomic classification and determination of a property of interest of the test cell substrate. The characterization may be based on mass-spectrometric measurement data. The property of interest may be a resistance or susceptibility to a growth-influencing factor. After comparing first spectrometric measurement data of the test cell substrate with a provided reference library, a sub-library is created comprising those reference datasets from the reference library that are classified as allowing a taxonomic classification of the test cell substrate. Second spectrometric measurement data after a second preparation of the test cell substrate under conditions that serve to determine a property of interest of the test cell substrate is compared with the sub-library and allow a reliable determination of the property of interest.

IPC Classes  ?

• C12Q 1/18 - Testing for antimicrobial activity of a material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Goods & Services

Computer software and computer programs for instrument control of ion mobility spectrometers, mass spectrometers, and combined ion mobility-mass spectrometers, including combined trapped ion mobility-time of flight mass spectrometers, combined trapped ion mobility-Fourier transform ion cyclotron resonance mass spectrometers, combined trapped ion mobility-ion trap mass spectrometers, and combined trapped ion mobility-quadrupole mass spectrometers; Computer software and computer programs for acquiring, processing and presenting data from ion mobility spectrometers, mass spectrometers, and combined ion mobility-mass spectrometers, including combined trapped ion mobility-time of flight mass spectrometers, combined trapped ion mobility-Fourier transform ion cyclotron resonance mass spectrometers, combined trapped ion mobility-ion trap mass spectrometers, and combined trapped ion mobility-quadrupole mass spectrometers; Pre-recorded data carriers carrying the aforementioned software; all aforementioned goods for research purposes, and not for the medical, dental or veterinary fields and their applications, and not for the field of non-destructive testing and its applications.

Goods & Services

Computer software and computer programs for processing, evaluating and displaying data obtained from an analytical and scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for processing data obtained from an analytical and scientific instrument, namely spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for searching Omics data in real-time, in particular spectrometric proteomics data, lipidomics data, metabolomics data and the like; Computer software and computer programs for operating an analytical and scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Analytical and scientific instruments, namely spectrometers, in particular mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers. Medical and veterinary diagnostic instruments, in particular mass spectrometers, combined chromatograph mass spectrometers.

Abstract

The invention relates to devices and methods for desorption scanning of analyte material deposited on a sample support, which can comprise the following mode of operation: (a) setting a position of the support to approach an impingement region onto which a beam is directed for local desorption of analyte material; (b) determining an actual position of the support after setting the position; (c) comparing the determined actual position with a target position of the support to determine any deviation; (d) adjusting a beam orientation, if a deviation is detected, so that the beam is directed onto the impingement region on the support that results when there is no deviation; (e) applying the beam to the impingement region to locally desorb analyte material and deliver it to an analyzer; and (f) checking whether a predetermined end condition is satisfied and, if not, repeating steps (a)-(e) for a subsequent non-congruent impingement region.

IPC Classes  ?

• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• G06T 7/70 - Determining position or orientation of objects or cameras

Abstract

The invention provides (a) a time-of-flight mass spectrometer with an acceleration region, a single-stage or multi-stage reflector, and an ion detector, further comprising an additional reflector whose potential has, at least in a subregion, a two-dimensional logarithmic potential component and a two-dimensional octopole potential component, and (b) methods for operating the time-of-flight mass spectrometer.

IPC Classes  ?

• H01J 49/40 - Time-of-flight spectrometers
• H01J 49/06 - Electron- or ion-optical arrangements
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

The invention proposes preparing biological samples for spectrometry which contain cell structures and/or whole cells of human or animal origin (e.g. thin human and animal tissue sections) or prokaryotes (e.g. microorganisms), and which require constant relative humidity, in a temperature-controlled gas volume whose humidity is determined by a saturated substance solution, for example a suitable salt solution. The invention exploits a physico-chemical phenomenon called “deliquescence”, which manifests itself by keeping the relative humidity above the saturated substance solution constant with a high degree of precision when a specified temperature is maintained. Pure succinic acid exhibits deliquescence at approx. 99% relative humidity, for example. Since an enormous variety of deliquescent salts and other suitable substances are available, it is possible to find the suitable substance for almost any desired relative humidity, with adjustment of the temperature, where necessary.

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• G01N 1/40 - Concentrating samples
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components

Abstract

Disclosed is a method and device for the mass spectrometric quantification of two or more known target ion species, in which a mass spectrometric signal, composed of signal components of the two or more target ion species, which are not mass resolved in the mass spectrum, is weighted with quantification functions and summed, and a quantification parameter is determined for the two or more target ion species from the weighted sums.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

The invention relates to a method for the preparation of living, microbial samples and microorganisms for subsequent mass spectrometric measurement and evaluation. Findings which can be derived from such a measurement can particularly serve the faster identification of microorganisms in the microbial sample according to species/subspecies and/or the fast determination of resistance/sensitivity of the microorganisms to antimicrobial substances and/or the further characterization of microorganisms, for example in respect of pathogenicity, virulence and metabolism. According to a preferred embodiment of the invention, the preparation particularly takes place directly on a mass spectrometric sample support.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/18 - Testing for antimicrobial activity of a material

Goods & Services

Chemical preparations-for scientific and analytical purposes, other than medical and veterinary purposes, chemical preparations for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph, in particular stationary phases (resins) and mobile phases; chemicals for use in chromatography [other than medical and veterinary]; media, namely media for separating substances in liquids, for scientific and analytical purposes, other than medical and veterinary purposes, in particular media for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph, in particular stationary phases (resins) and mobile phases; media for use in chromatography [not medical], in particular stationary phases and mobile phases; kits, namely preconfigured sets of stationary phases and mobile phases for separating substances in liquids, for scientific and analytical purposes, other than medical and veterinary purposes, in particular kits for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph; kits containing preconfigured media including both a stationary phase and a mobile phase for use in chromatography [not medical]. Parts of apparatus and instruments of scientific and analytical liquid phase handling devices, especially parts of chromatographs such as liquid chromatographs, in particular chromatography columns, connectors for capillary tubes, fittings for capillary tubes, liquid lines, adapters for capillary tubes and liquid lines, capillary tubes, liquid chromatography injectors and connecting elements for capillary tubes and liquid lines; accessories and components of scientific and analytical liquid phase handling devices, especially accessories and components for chromatographs such as liquid chromatographs, namely chromatography columns, connectors for capillary tubes, fittings for capillary tubes, liquid lines, adapters for capillary tubes and liquid lines, capillary tubes, liquid chromatography injectors and connecting elements for capillary tubes and liquid lines; chromatography columns for laboratory use, liquid chromatography columns for laboratory use; capillary tubes for laboratory use; adapters for capillary tubes for laboratory use; connectors for capillary tubes for laboratory use; fittings for capillary tubes for laboratory use; liquid chromatography injectors for scientific use; fluid lines being parts of liquid chromatography apparatus for laboratory use; connecting elements for fluid lines being parts of liquid chromatography apparatus for laboratory use.

Abstract

Disclosed is a method for analytically measuring sample material deposited on a sample support surface, comprising: (a) defining a plurality of regions on the surface, several of which are in contact with sample material, (b1) sampling sections of sample on a region using a desorbing beam to generate desorbed molecules, which are ionized and transferred to an analyzer, (b2) in so doing, sweeping the region by changing an orientation setting of the beam relative to the surface along a non-rectilinear trajectory on the region selected from a plurality of predefined, non-rectilinear trajectories while keeping the support in one position, (c) transitioning from a swept region to a region to be swept next using spatial adjustment of the support, and (d) repeating steps (b1), (b2), and (c) until a predetermined termination condition is fulfilled. A system for analyzing ions, having an ion generation device and a control unit is also disclosed.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• H01J 49/40 - Time-of-flight spectrometers

Goods & Services

Chemical preparations-for scientific and analytical purposes, other than medical and veterinary purposes, chemical preparations for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph, in particular stationary phases (resins) and mobile phases; chemicals for use in chromatography [other than medical and veterinary]; media, namely media for separating substances in liquids, for scientific and analytical purposes, other than medical and veterinary purposes, in particular media for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph, in particular stationary phases (resins) and mobile phases; media for use in chromatography [not medical], in particular stationary phases and mobile phases; kits, namely preconfigured sets of stationary phases and mobile phases for separating substances in liquids, for scientific and analytical purposes, other than medical and veterinary purposes, in particular kits for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph; kits containing preconfigured media including both a stationary phase and a mobile phase for use in chromatography [not medical]. Parts of apparatus and instruments of scientific and analytical liquid phase handling devices, especially parts of chromatographs such as liquid chromatographs, in particular chromatography columns, connectors for capillary tubes, fittings for capillary tubes, liquid lines, adapters for capillary tubes and liquid lines, capillary tubes, liquid chromatography injectors and connecting elements for capillary tubes and liquid lines; accessories and components of scientific and analytical liquid phase handling devices, especially accessories and components for chromatographs such as liquid chromatographs, namely chromatography columns, connectors for capillary tubes, fittings for capillary tubes, liquid lines, adapters for capillary tubes and liquid lines, capillary tubes, liquid chromatography injectors and connecting elements for capillary tubes and liquid lines; chromatography columns for laboratory use, liquid chromatography columns for laboratory use; capillary tubes for laboratory use; adapters for capillary tubes for laboratory use; connectors for capillary tubes for laboratory use; fittings for capillary tubes for laboratory use; liquid chromatography injectors for scientific use; fluid lines being parts of liquid chromatography apparatus for laboratory use; connecting elements for fluid lines being parts of liquid chromatography apparatus for laboratory use.

Abstract

An apparatus for analyzing peak data generated from mass signals acquired by a mass spectrometric system comprises: a streaming device that comprises a first network interface and is configured to generate peak data from the mass signals or receive peak data generated externally from the mass signals, group the peak data into independently-processable data packets related to a processing task, and distribute the data packets in a task-specific stream via the first network interface onto a network; and at least one analyzing device that comprises a second network interface and is configured to retrieve a data packet of the task-specific stream via the second network interface from the network, perform the processing task on the retrieved data packet to produce result data, package the result data in a result data packet, and distribute the result data packet via the first network interface onto the network.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
• H01J 49/40 - Time-of-flight spectrometers
• G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry
• H01J 49/06 - Electron- or ion-optical arrangements
• H01J 49/10 - Ion sourcesIon guns

Goods & Services

Downloadable computer software and computer programs for instrument control of analytical measuring instruments, including mass spectrometers and infrared spectrometers; Downloadable computer software and computer programs for processing and presenting data acquired with analytical measuring instruments, including data from mass spectrometers and infrared spectrometers; Downloadable computer software and computer programs for monitoring and optimizing adjustable instrument parameters of analytical measuring instruments to keep their performance at optimal level, including mass spectrometers and infrared spectrometers; Pre-recorded data carriers carrying the aforementioned software

Abstract

An apparatus to generate ions from sample material deposited on a substrate which is at least partially transparent to electromagnetic waves, comprises: —a support device having a holder for the substrate, —a desorption/ionization unit including a desorption device and an ionization device, said desorption device being configured to desorb deposited sample material from a desorption site on the substrate using at least one energy burst, and said ionization device being configured to irradiate the desorbed sample material above the substrate with electromagnetic waves after the at least one energy burst, wherein the electromagnetic waves pass through the substrate before encountering the desorbed sample material at a location which corresponds to the desorption site, and —an extraction device which is arranged and designed to extract ions from the desorbed sample material and transfer them into an analyzer. The invention also relates to a correspondingly arranged method.

IPC Classes  ?

• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures

Abstract

The invention relates to the preparation of biological cells for the mass spectrometric analysis of cellular properties such as taxonomic classification, antibiotic resistances, response to drugs or other active substances, and others. The cells can be prokaryotic or eukaryotic microorganisms which have particularly been cultivated directly on a mass spectrometric sample support, or eukaryotic cells from tissues or cell cultures. The invention proposes that the cells are not disrupted by adding matrix solution for a subsequent ionization by matrix-assisted laser desorption (MALDI), but that they are disrupted in a separate treatment step using acids and/or solvents on the sample support itself. Surprisingly, the cell proteins released then adhere to the sample support so that they can be carefully washed with buffer solution to remove salts and other soluble impurities which can stem from earlier treatment steps, for example from nutrient solution.

IPC Classes  ?

• G01N 1/40 - Concentrating samples
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12Q 1/18 - Testing for antimicrobial activity of a material
• G01N 1/28 - Preparing specimens for investigation
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to a method for the determination and visualization of the spatial distribution of tissue states of a tissue sample, wherein a mass/mobility map is acquired at each of a plurality of sample sites of the tissue sample, the signal heights at each sample site are determined at characteristic signal positions in the corresponding mass/mobility map, from which a tissue state for each sample site is calculated with the aid of a mathematical/statistical classification algorithm, and the spatial distribution of the tissue states calculated for the sample sites is represented graphically.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 33/483 - Physical analysis of biological material
• B01D 59/44 - Separation by mass spectrography
• G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber

Goods & Services

Chemical preparations for scientific purposes [other than medical or veterinary purposes], in particular chemical preparations for scientific purposes for use with a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Chemical reagents for scientific purposes [other than medical or veterinary purposes], in particular chemical reagents for scientific purposes for use with a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS). Chemical-pharmaceutical preparations, in particular chemical-pharmaceutical preparations for use with a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Chemical preparations for medical, veterinary or pharmaceutical purposes, in particular chemical preparations for medical, veterinary or pharmaceutical purposes for use with a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Chemical reagents for medical, veterinary or pharmaceutical purposes, in particular chemical reagents for medical, veterinary or pharmaceutical purposes for use with a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS). Computer programs and computer software for operating and controlling an analytical or technical measuring instrument, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Computer programs and computer software for operating and controlling an analytical device for medical purposes, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Computer programs and computer software for operating and controlling an analytical device for the identification of microbes for medical purposes, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Computer programs and computer software for processing, evaluating and displaying data recorded with an analytical or technical measuring instrument, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Computer programs and computer software for processing, evaluating and displaying data recorded with an analytical device for medical purposes, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Computer programs and computer software for processing, evaluating and displaying data recorded with an analytical device for identifying microbes for medical purposes, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS).

Goods & Services

Chemical preparations for scientific and analytical purposes, other than medical and veterinary purposes; chemical preparations for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, other than medical and veterinary purposes, in particular for use with a chromatograph such as a liquid chromatograph, in particular stationary phases being resins or fills of functionalized particles and mobile phases; chemicals for use in chromatography, other than for medical and veterinary purposes; media, namely, media for separating substances in liquids, for scientific and analytical purposes, other than medical and veterinary purposes, in particular media for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph, in particular stationary phases being resins or fills of functionalized particles and mobile phases, namely, chromatography separation media for separation of a mixture into components; media for use in chromatography, not for medical purposes, in particular stationary phases and mobile phases, namely, chromatography separation media for separation of a mixture into components; kits, namely, preconfigured sets of stationary phases and mobile phases for separating substances in liquids, for scientific and analytical purposes, other than medical and veterinary purposes, in particular kits for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph, namely, kits comprised of chromatography separation media for separation of a mixture into components; kits containing preconfigured media including both a stationary phase and a mobile phase for use in chromatography, not for medical purposes, namely, kits comprised of chromatography separation media for separation of a mixture into components Parts of apparatus and instruments of scientific and analytical liquid phase handling devices, namely, structural parts of chromatographs such as liquid chromatographs, namely, chromatography columns, connectors for capillary tubes, structural fittings for capillary tubes for samples, liquid lines, adapters for capillary tubes and liquid lines, capillary tubes, liquid chromatography injectors and connecting elements for capillary tubes and liquid lines; structural accessories and components of scientific and analytical liquid phase handling devices, namely, structural accessories and components for chromatographs such as liquid chromatographs, namely, chromatography columns, connectors for capillary tubes, structural fittings for capillary tubes, liquid lines, adapters for capillary tubes and liquid lines, capillary tubes, liquid chromatography injectors and connecting elements for capillary tubes and liquid lines; chromatography columns for laboratory use, liquid chromatography columns for laboratory use; capillary tubes for samples for laboratory use; adapters for capillary tubes for samples for laboratory use; structural connectors for capillary tubes for samples for laboratory use; structural fittings for capillary tubes for samples for laboratory use; liquid chromatography injectors for scientific use; fluid lines being structural parts of liquid chromatography apparatus for laboratory use; connecting elements for fluid lines being structural parts of liquid chromatography apparatus for laboratory use

Goods & Services

Chemical preparations for scientific and analytical purposes, other than medical and veterinary purposes; chemical preparations for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, other than medical and veterinary purposes, in particular for use with a chromatograph such as a liquid chromatograph, in particular stationary phases being resins or fills of functionalized particles and mobile phases; chemicals for use in chromatography, other than for medical and veterinary purposes; media, namely, media for separating substances in liquids, for scientific and analytical purposes, other than medical and veterinary purposes, in particular media for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph, in particular stationary phases being resins or fills of functionalized particles and mobile phases, namely, chromatography separation media for separation of a mixture into components; media for use in chromatography, not for medical purposes, in particular stationary phases and mobile phases, namely, chromatography separation media for separation of a mixture into components; kits, namely, preconfigured sets of stationary phases and mobile phases for separating substances in liquids, for scientific and analytical purposes, other than medical and veterinary purposes, in particular kits for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph, namely, kits comprised of chromatography separation media for separation of a mixture into components; kits containing preconfigured media including both a stationary phase and a mobile phase for use in chromatography, not for medical purposes, namely, chromatography separation media for separation of a mixture into components Parts of apparatus and instruments of scientific and analytical liquid phase handling devices, namely, structural parts of chromatographs such as liquid chromatographs, namely, chromatography columns, connectors for capillary tubes, structural fittings for capillary tubes for samples, liquid lines, adapters for capillary tubes and liquid lines, capillary tubes, liquid chromatography injectors and connecting elements for capillary tubes and liquid lines; structural accessories and components of scientific and analytical liquid phase handling devices, namely, structural accessories and components for chromatographs such as liquid chromatographs, namely, chromatography columns, connectors for capillary tubes, structural fittings for capillary tubes, liquid lines, adapters for capillary tubes and liquid lines, capillary tubes, liquid chromatography injectors and connecting elements for capillary tubes and liquid lines; chromatography columns for laboratory use, liquid chromatography columns for laboratory use; capillary tubes for samples for laboratory use; adapters for capillary tubes for samples for laboratory use; structural connectors for capillary tubes for samples for laboratory use; structural fittings for capillary tubes for samples for laboratory use; liquid chromatography injectors for scientific use; fluid lines being structural parts of liquid chromatography apparatus for laboratory use; connecting elements for fluid lines being structural parts of liquid chromatography apparatus for laboratory use

Goods & Services

Reagents, media and kits for non-medical, non-clinical and non-veterinary diagnostics, in particular reagents, media and kits for separating and processing microbial and non-microbial cells, including bacteria, yeasts and fungi, and particles including virions, from a liquid culture. Reagents, media and kits for medical, clinical and veterinary diagnostics, in particular reagents, media and kits for separating and processing microbial and non-microbial cells, including bacteria, yeasts and fungi, and particles including virions, from a liquid culture, including a body fluid culture, in particular a blood culture. Computer programs and computer software for processing analysis data, including spectrometric data including mass spectra, and for identifying microorganisms including bacteria, yeasts and fungi, and particles including virions in a liquid culture from biological, industrial and food samples.

Goods & Services

Reagents for research purposes, cell culture media, lysis buffer solutions for use in analytical chemistry, washing buffer solutions for use in analytical chemistry, matrix substance media comprised of sinapinic acids, hydroxycinnamic acids, and dihydroxybenzoic acids, and chemical-biological test kits for detecting sepsis for research use for non-medical, non-clinical and non-veterinary diagnostics, in particular reagents for research purposes, cell culture media, lysis buffer solutions for use in analytical chemistry, washing buffer solutions for use in analytical chemistry, matrix substance media comprised of sinapinic acids, hydroxycinnamic acids, and dihydroxybenzoic acids, and chemical-biological test kits for for detecting sepsis for research use that separates and processes microbial and non-microbial cells, including bacteria, yeasts and fungi, and particles including virions, from a liquid culture Reagents for medical use, culture media and diagnostic media for use with detecting sepsis, and diagnostic kits comprised of medical diagnostic reagents and assays for testing blood for use in detecting sepsis, for medical, clinical and veterinary diagnostics, in particular reagents for medical use, culture media and diagnostic media for use with detecting sepsis, and diagnostic kits comprised of medical diagnostic reagents and assays for testing blood for use in detecting sepsis that separates and processes microbial and non-microbial cells, including bacteria, yeasts and fungi, and particles including virions, from a liquid culture, including a body fluid culture, in particular a blood culture Downloadable computer programs and computer software for processing and analysis of spectrometric and mass spectra data, and for identifying microorganisms including bacteria, yeasts and fungi, and particles including virions in a liquid culture from biological, industrial and food samples

Goods & Services

Downloadable computer programs and computer software for operating and controlling an analytical or technical measuring instrument, in particular a mass spectrometer, a liquid chromatography-ion mobility spectrometer, a liquid chromatography-mass spectrometer or a liquid chromatography-ion mobility-mass spectrometer; downloadable computer programs and computer software for operating and controlling an analytical device for medical purposes, in particular a mass spectrometer, a liquid chromatography-ion mobility spectrometer, a liquid chromatography-mass spectrometer or a liquid chromatography-ion mobility-mass spectrometer; downloadable computer programs and computer software for operating and controlling an analytical device for the identification of microbes for medical purposes, in particular a mass spectrometer, a liquid chromatography-ion mobility spectrometer, a liquid chromatography-mass spectrometer or a liquid chromatography-ion mobility-mass spectrometer; downloadable computer programs and computer software for processing, evaluating and displaying data recorded with an analytical or technical measuring instrument, in particular a mass spectrometer, a liquid chromatography-ion mobility spectrometer, a liquid chromatography-mass spectrometer or a liquid chromatography-ion mobility-mass spectrometer; downloadable computer programs and computer software for processing, evaluating and displaying data recorded with an analytical device for medical purposes, in particular a mass spectrometer, a liquid chromatography-ion mobility spectrometer, a liquid chromatography-mass spectrometer or a liquid chromatography-ion mobility-mass spectrometer; downloadable computer programs and computer software for processing, evaluating and displaying data recorded with an analytical device for identifying microbes for medical purposes, in particular a mass spectrometer, a liquid chromatography-ion mobility spectrometer, a liquid chromatography-mass spectrometer or a liquid chromatography-ion mobility-mass spectrometer

Abstract

An ion mobility separator includes an ion path with a central axis along which ions travel, the ion path containing a gas. A first force is applied to the ions in a first axial direction, and a second force that varies spatially along the ion path is applied to the ions in second axial direction opposite the first axial direction. A rotating confinement field has a radially-inhomogeneous electric potential with relative maxima and minima that rotate about the central axis as a function of time, the confinement field exerting a radial confinement force on the ions in a radial direction toward the central axis. The ion mobility separator may be operated at elevated pressures including ambient pressure and higher. The first and/or second axial forces may be a constant or gradient gas flow, a constant or gradient electric field or an axial component of the rotating confinement field.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• H01J 49/06 - Electron- or ion-optical arrangements
• H01J 49/10 - Ion sourcesIon guns
• H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Goods & Services

Chemical preparations, media and kits for scientific and analytical purposes, other than medical and veterinary purposes, in particular chemical preparations, media and kits for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph, in particular stationary phases (resins) and mobile phases. Accessories and components of scientific and analytical liquid phase handling devices, especially accessories and components for chromatographs such as liquid chromatographs, in particular columns, connectors, fittings, fluid lines, adapters, tubes, capillaries, injection systems and connecting elements.

Goods & Services

Chemical preparations, media and kits for scientific and analytical purposes, other than medical and veterinary purposes, in particular chemical preparations, media and kits for scientific and analytical purposes for use with a scientific and analytical liquid-phase handling device, in particular for use with a chromatograph such as a liquid chromatograph, in particular stationary phases (resins) and mobile phases. Accessories and components of scientific and analytical liquid phase handling devices, especially accessories and components for chromatographs such as liquid chromatographs, in particular columns, connectors, fittings, fluid lines, adapters, tubes, capillaries, injection systems and connecting elements.

Abstract

Disclosed is a device to generate ions from a deposited sample, comprising: A chamber which is arranged and designed to keep the deposited sample in a conditioned environment comprising a dopant gas, A desorption device which is arranged and designed to desorb the deposited sample in the chamber using an energy burst, An ionization device which, for the purpose of ionization, is arranged and designed to irradiate the desorbed sample in the chamber using coherent electromagnetic waves or expose it to an electric discharge, a plasma, or light of an arc discharge lamp with broadband emission spectrum, which are chosen such that the dopant gas is receptive to them, and An extraction device which is arranged and designed to extract ions from the desorbed sample and transfer them into an analyzer. Disclosed is also a method which is preferably conducted on such a device.

IPC Classes  ?

• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components

Abstract

An apparatus and a method of data independent combined ion mobility and mass spectroscopy analysis includes introducing precursor ions into an ion mobility spectrometer (IMS), sequentially releasing precursor ions from said IMS according to their ion mobility, introducing said released precursor ions into a mass filter, fragmenting the precursor ions transmitted through said mass filter to generate fragment ions, and carrying out a mass spectroscopy measurement on said fragment ions. The IMS and mass filter are controlled in a synchronized manner to carry out a plurality of IM scans, wherein adjacent mass windows in said IM scan that are associated with consecutive mass spectroscopy measurements of fragment ions overlap, such that precursor ions transmitted through said mass filter during said IM scan are located in at least one continuous scan region in an m/z-IM plane which extends in a generally diagonal direction in said m/z-IM plane.

IPC Classes  ?

• G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Abstract

The disclosure relates to a method for processing a mass spectrum, comprising: (i) providing the mass spectrum which contains a plurality of data pairs, each data pair being representative of a mass value or mass-related value on a mass scale or mass-related scale and an abundance value or abundance-related value associated with the respective mass value or mass-related value, (ii) selecting a plurality of intervals on the mass scale or mass-related scale, each interval containing a multitude of the said data pairs, (iii) for each interval, applying a first mathematical-statistical analysis to the said data pairs contained in the respective interval in order to derive an interval-specific peak width, and (iv) using the said interval-specific peak widths to determine an estimated peak width for each mass value or mass-related value on the mass scale or mass-related scale.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 33/483 - Physical analysis of biological material

Abstract

The invention proposes preparing biological samples for spectrometry which contain cell structures and/or whole cells of human or animal origin (e.g. thin human and animal tissue sections) or prokaryotes (e.g. microorganisms), and which require constant relative humidity, in a temperature-controlled gas volume whose humidity is determined by a saturated substance solution, for example a suitable salt solution. The invention exploits a physico-chemical phenomenon called “deliquescence”, which manifests itself by keeping the relative humidity above the saturated substance solution constant with a high degree of precision when a specified temperature is maintained. Pure succinic acid exhibits deliquescence at approx. 99% relative humidity, for example. Since an enormous variety of deliquescent salts and other suitable substances are available, it is possible to find the suitable substance for almost any desired relative humidity, with adjustment of the temperature, where necessary.

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• G01N 1/40 - Concentrating samples
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components

Abstract

The invention relates to a method to evaluate mass spectrometry data for the analysis of peptides from biological samples, particularly MALDI-TOF mass spectrometry data, comprising the steps of: providing expected mass defects; determining measured mass defects, i.e. the mass defects resulting from the mass spectrometry data; and comparing the measured mass defects with the expected mass defects.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• H01J 49/00 - Particle spectrometers or separator tubes

Goods & Services

Computer programs and computer software for acquiring, processing, evaluating and displaying data from liquid and gas chromatographs, mass spectrometers, ion mobility spectrometers, and combinations of the afore-mentioned, in particular measurement data of biological samples and biomolecules; computer programs and computer software for collisional cross section (CCS) -aware acquiring, processing, evaluating and displaying of analytical data; computer programs and computer software for CCS-enabled searching of databases, in particular for identifying biomolecules.

Goods & Services

Reagents, media and kits for non-medical, non-clinical and non-veterinary diagnostics, in particular reagents, media and kits for separating and processing microbial and non-microbial cells, including bacteria, yeasts and fungi, and particles including virions, from a liquid culture. Reagents, media and kits for medical, clinical and veterinary diagnostics, in particular reagents, media and kits for separating and processing microbial and non-microbial cells, including bacteria, yeasts and fungi, and particles including virions, from a liquid culture, including a body fluid culture, in particular a blood culture. Computer programs and computer software for processing analysis data, including spectrometric data including mass spectra, and for identifying microorganisms including bacteria, yeasts and fungi, and particles including virions in a liquid culture from biological, industrial and food samples.

Goods & Services

Downloadable computer programs and computer software for acquiring, processing, evaluating and displaying data from liquid and gas chromatographs, mass spectrometers, ion mobility spectrometers, and combinations of the afore-mentioned, in particular measurement data of biological samples and biomolecules; downloadable computer programs and computer software for collisional cross section (CCS) -aware acquiring, processing, evaluating and displaying of analytical data; downloadable computer programs and computer software for CCS-enabled searching of databases, in particular for identifying biomolecules

Abstract

x,y). The invention also relates to methods for acquiring and processing ion-spectrometric measurement signal data, and ion mobility-mass spectrometers.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Goods & Services

Chemical preparations for scientific purposes [other than medical or veterinary purposes], in particular chemical preparations for scientific purposes for use with a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Chemical reagents for scientific purposes [other than medical or veterinary purposes], in particular chemical reagents for scientific purposes for use with a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS). Chemical-pharmaceutical preparations, in particular chemical-pharmaceutical preparations for use with a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Chemical preparations for medical, veterinary or pharmaceutical purposes, in particular chemical preparations for medical, veterinary or pharmaceutical purposes for use with a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Chemical reagents for medical, veterinary or pharmaceutical purposes, in particular chemical reagents for medical, veterinary or pharmaceutical purposes for use with a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS). Computer programs and computer software for operating and controlling an analytical or technical measuring instrument, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Computer programs and computer software for operating and controlling an analytical device for medical purposes, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Computer programs and computer software for operating and controlling an analytical device for the identification of microbes for medical purposes, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Computer programs and computer software for processing, evaluating and displaying data recorded with an analytical or technical measuring instrument, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Computer programs and computer software for processing, evaluating and displaying data recorded with an analytical device for medical purposes, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS); Computer programs and computer software for processing, evaluating and displaying data recorded with an analytical device for identifying microbes for medical purposes, in particular a mass spectrometer (MS), a liquid chromatography-ion mobility spectrometer (LC-IMS), a liquid chromatography-mass spectrometer (LC-MS) or a liquid chromatography-ion mobility-mass spectrometer (LC-IMS-MS).

Abstract

The invention relates to methods for operating a microfluidic device in the analysis of sample substances, comprising: (i) providing the microfluidic device, which contains an array of separate sensor spots; (ii) addressing a first selection of the sensor spots with sample substances taken up in fluid, said first selection not comprising the whole array of sensor spots; (iii) optically sensing of the first selection of sensor spots for an interaction with the sample substances; (iv) changing the operation of the microfluidic device in response to the optically sensed interaction, by addressing a second selection of the sensor spots with the sample substances taken up in fluid, said second selection not being identical to the first selection, and (v) analyzing the sample substances by optical sensing of a third selection of sensor spots which is part of the second selection. The invention likewise relates to a corresponding arrangement with microfluidic device.

IPC Classes  ?

• G01N 21/55 - Specular reflectivity
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 21/552 - Attenuated total reflection
• G01N 33/553 - Metal or metal coated
• G02B 5/00 - Optical elements other than lenses
• G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light

Abstract

6 secondary electrons per impinging ion results, while the output current of the secondary-electron multiplier is amplified using an electronic preamplifier mounted close to the secondary-electron multiplier with such a low noise level that the current pulses of individual ions impinging on the ion detector are detected above the noise at the input of a digitizing unit. Further disclosed are the use of the methods for imaging mass spectrometric analysis of a thin tissue section or mass spectrometric high-throughput analysis/massive-parallel analysis, and a time-of-flight mass spectrometer whose control unit is programmed to execute such methods.

IPC Classes  ?

• H01J 49/40 - Time-of-flight spectrometers
• H01J 49/02 - Particle spectrometers or separator tubes Details
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

The invention relates to a method for the spectrometric characterization of microorganisms, comprising: providing a test microorganism; acquiring spectrometric measurement data from the test microorganism under potential exposure to variance that is not based on taxonomic classification; selecting a classifier which is trained to determine the identity of a microorganism on a second taxonomic level; and applying the classifier to the measurement data in order to determine the identity of the test microorganism on the second taxonomic level, wherein the classifier is variance-conditioned in such a way that it largely or completely masks out the effect of variance in the characterization of the test microorganism on the second taxonomic level.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

Goods & Services

Computer software and computer programs for processing, evaluating and displaying data obtained from an analytical and scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; computer software and computer programs for processing data obtained from an analytical and scientific instrument, namely spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; computer software and computer programs for searching Omics data in real-time, in particular spectrometric proteomics data, lipidomics data, metabolomics data; computer software and computer programs for operating an analytical and scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; analytical and scientific instruments, namely spectrometers, in particular mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers; all of the afore-mentioned goods not in the field of particle accelerator science.

Abstract

The invention relates to methods for drawing-off liquid from individual droplets which are in a predefined arrangement on a flat substrate and have sedimented material enclosed in them. A mask of an absorbent material comprising a pattern of indentations or holes which corresponds at least partially to the regular arrangement of the individual droplets, or a stiff, rigid plate of an absorbent material is positioned above the flat substrate in such a way that the droplets come into contact with the absorbent material peripherally so that liquid is drawn off there-into. The invention also relates to a mask of an absorbent material with a substantially rectangular shape which has a predefined pattern of indentations or holes for the purpose of separating liquid and sedimented material enclosed therein.

IPC Classes  ?

• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• G01N 1/28 - Preparing specimens for investigation
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Goods & Services

Computer programs and computer software for acquiring, processing, evaluating and displaying data from liquid and gas chromatographs, mass spectrometers, ion mobility spectrometers, and combinations of the afore-mentioned, in particular measurement data of biological samples and biomolecules; Computer programs and computer software for collisional cross section (CCS) -aware acquiring, processing, evaluating and displaying of analytical data; Computer programs and computer software for CCS-enabled searching of databases, in particular for identifying biomolecules.

Abstract

The invention relates to a microbial test standard for use in infrared spectrometry which has at least two resealable vessels which are liquid-tight when closed, each of which contains a predefined amount of dried biomass of a microorganism. The microorganisms in the different vessels differ in at least one characteristic, which is selected in particular from the group comprising species, subspecies, strain, serovar, pathovar, toxivar and variety, and the difference manifests itself in a predefined intermicrobial spectral distance. The disclosure furthermore comprises a method of using the microbial test standard.

IPC Classes  ?

• G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 1/31 - Apparatus therefor
• G01N 1/38 - Diluting, dispersing or mixing samples
• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
• G01N 1/28 - Preparing specimens for investigation

Goods & Services

Downloadable computer software and downloadable computer programs for processing, evaluating and displaying data obtained from an analytical and scientific instrument, namely, a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; downloadable computer software and downloadable computer programs for processing data obtained from an analytical and scientific instrument, namely, spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; downloadable computer software and downloadable computer programs for searching Omics data in real-time, in particular spectrometric proteomics data, lipidomics data, metabolomics data; downloadable computer software and downloadable computer programs for operating an analytical and scientific instrument, namely, a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; analytical and scientific instruments, namely, spectrometers, in particular mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers; all of the afore-mentioned goods not in the field of particle accelerator science

Abstract

The invention relates to the preparation of samples for mass spectrometric analyses with matrix-assisted ionization (e.g. MALDI), particularly using the matrix material 2,5-dihydroxyacetophenone (DHAP), and comprises sample preparation in microvessels with the addition of beads or other solid bodies. In this way, particularly thorough mixing can be achieved by shaking (“vortexing”) the microvessels, on the one hand, while crystallization of the matrix material can be initiated in the liquid, on the other hand. It is sufficient to have around 5 to 15 glass beads, 0.5 millimeters in diameter, which scrape against each other and against the vessel wall, and thus cause a DHAP solution to start becoming turbid after one to two minutes by forming tiny crystal nuclei. This allows simultaneous, fully automated preparation of, in particular, a large number of samples, including pipetting onto sample support plates by means of a pipetting and shaking robot.

IPC Classes  ?

• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

The invention relates to the identification and visualization of the spatial distribution of particular tissue states in histological tissue sections from mass spectrometric signals acquired with spatial resolution. The invention proposes a method by means of which regions of the tissue with similar mass spectra are found automatically, and it is further proposed that mass spectra of these regions are summed in order to improve the spectral quality to such an extent that known markers for tissue degenerations can be identified with increased certainty. Regions of similar mass spectra can be interconnected on a large scale, but can also be isolated from each other on a small scale.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• G01N 1/28 - Preparing specimens for investigation
• H01J 49/40 - Time-of-flight spectrometers
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Goods & Services

Apparatus and equipment for the analysis of biological samples for scientific purposes, in particular robotic equipment for clinical, veterinary or environmental microbiological analysis; robotic equipment for the identification of microorganisms for scientific purposes. Apparatus and equipment for the analysis of biological samples for medical diagnostics, in particular robotic equipment for clinical, veterinary or environmental microbiological analysis; robotic equipment for the identification of microorganisms for medical purposes.

Abstract

The invention relates to a method for the determination and visualization of the spatial distribution of tissue states of a tissue sample, wherein a mass/mobility map is acquired at each of a plurality of sample sites of the tissue sample, the signal heights at each sample site are determined at characteristic signal positions in the corresponding mass/mobility map, from which a tissue state for each sample site is calculated with the aid of a mathematical/statistical classification algorithm, and the spatial distribution of the tissue states calculated for the sample sites is represented graphically.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 33/483 - Physical analysis of biological material
• B01D 59/44 - Separation by mass spectrography
• G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber

Abstract

The invention relates to hybrid IMS/MS systems and provides hybrid IMS/MS system comprising an RF funnel, an ion mobility analyzer and a mass analyzer wherein the RF funnel is arranged non-collinearly to the ion mobility analyzer, preferably a TIMS analyzer (TIMS=trapped ion mobility spectrometry).

IPC Classes  ?

• H01J 49/40 - Time-of-flight spectrometers
• H01J 49/10 - Ion sourcesIon guns
• G01N 27/622 - Ion mobility spectrometry
• H01J 49/06 - Electron- or ion-optical arrangements
• H01J 49/24 - Vacuum systems, e.g. maintaining desired pressures
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Goods & Services

Computer software and computer programs for processing, evaluating and displaying data obtained from an analytical and scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for processing data obtained from an analytical and scientific instrument, namely spectra of a spectrometer, in particular mass spectra of a mass spectrometer, ion mobility spectra of an ion mobility spectrometer or combined mobility-mass spectra of a combined ion mobility spectrometer-mass spectrometer; Computer software and computer programs for searching Omics data in real-time, in particular spectrometric proteomics data, lipidomics data, metabolomics data and the like; Computer software and computer programs for operating an analytical and scientific instrument, namely a spectrometer, in particular a mass spectrometer, ion mobility spectrometer or combined ion mobility spectrometer-mass spectrometer; Analytical and scientific instruments, namely spectrometers, in particular mass spectrometers, ion mobility spectrometers and combined ion mobility spectrometer-mass spectrometers; all of the afore-mentioned goods not in the field of particle accelerator science.

Abstract

The disclosure relates to a method which is suitable for the quality control and signal correction of mass spectrometry data of biological tissue samples and is based on the analysis of the chemical background signal observed in a spectrum. It exploits the fact that the chemical background signal contains components from a plurality of polymer molecules, whose chemical structure has strong regularities. These regularities mean that the observed masses are subject to certain statistical distributions, which are each characteristic of the class of molecule. By analyzing these statistical properties, it is possible to detect and correct any mass shifts which may be present.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
• G01N 33/483 - Physical analysis of biological material
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 29/46 - Processing the detected response signal by spectral analysis, e.g. Fourier analysis

Abstract

The present invention relates to a mass spectrometric method for determining isomeric amino acid residues of a peptide and comprises the steps of: generating a list of peptide candidates using the amino acid lead sequence of the peptide, said lead sequence comprising positions of determined amino acid residues and at least one position with undetermined isomeric amino acid residues; predicting the collision cross section for each peptide candidate; comparing the predicted collision cross section of each peptide candidate with an experimentally determined collision cross section of the peptide and assigning the isomeric amino acid residues of the best matching peptide candidate to the isomeric amino acid residues of the peptide.

IPC Classes  ?

• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention provides a method for acquiring as many fragment mass spectra of selected substances, e.g. proteins, of complex mixtures, as possible using a hybrid mass spectrometric system which comprises an ion source, an ion mobility separator, a mass filter, a fragmentation cell, and a mass analyzer. The fragment mass spectra are used for identifying the substances by their fragment mass spectra. The invention proposes to control the dwell time of the mass filter and to adapt the dwell time to the length of the ion mobility signal in a mass-mobility map.

IPC Classes  ?

• G01N 27/622 - Ion mobility spectrometry
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/40 - Time-of-flight spectrometers
• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
• G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry

Abstract

The invention relates to a method for the preparation of living, microbial samples and microorganisms for subsequent mass spectrometric measurement and evaluation. Findings which can be derived from such a measurement can particularly serve the faster identification of microorganisms in the microbial sample according to species/subspecies and/or the fast determination of resistance/sensitivity of the microorganisms to antimicrobial substances and/or the further characterization of microorganisms, for example in respect of pathogenicity, virulence and metabolism. According to a preferred embodiment of the invention, the preparation particularly takes place directly on a mass spectrometric sample support.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/18 - Testing for antimicrobial activity of a material

Abstract

The invention relates to imaging mass spectrometry on thin sample sections, in particular using MALDI, where a high lateral image resolution means that a plethora of mass spectra has to be acquired and the image acquisition runs over many hours. The quality of the mass spectra deteriorates considerably over time in such cases. The invention is based on the finding that the decrease in spectral quality of continuous measurement series over many hours is only partially caused by a decrease in detector gain, and that another significant cause is a decrease in the number of usable ions per ion generating pulse, which is attributable to several phenomena that are difficult to regulate. The invention now proposes to instead regulate only the detector gain, and such that not only the decrease in the detector gain is compensated, but also the decrease in the number of usable ions per ion generating pulse.

IPC Classes  ?

• H01J 49/02 - Particle spectrometers or separator tubes Details
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission

Goods & Services

Apparatus and equipment for the analysis of biological samples for scientific purposes, in particular robotic equipment, specifically laboratory robots for clinical, veterinary or environmental microbiological analysis; robotic equipment for the identification of microorganisms for scientific purposes in the nature of laboratory robots

Abstract

The present invention relates to a mass spectrometric method for determining (predicting) the presence or absence of a chemical element in an analyte which provides valuable information towards reduction of complexity for annotating a chemical formula to the analyte. The method is based on representing a measured isotopic pattern of an analyte as a feature vector and assigning the feature vector to the presence/absence class using a machine learning algorithm, like a support vector machine (SVM) or an artificial neural network (NN).

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G16C 20/20 - Identification of molecular entities, parts thereof or of chemical compositions
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G01N 30/72 - Mass spectrometers
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components

Abstract

The invention relates to a method for sample preparation on a spectrometric sample support, comprising the steps of: (i) providing the sample support with an arrangement of individual liquid droplets, for example of washing liquid or nutrient solution, each of which has microorganism sediments enclosed in it; (ii) locating a plate of an absorbent material containing cotton fibers, for example, above the sample support; (iii) lowering the plate vertically onto the sample support in such a way that microorganism sediments and plate come into contact, whereby the droplets of liquid are absorbed into the absorbent material; (iv) lifting the plate, which is locally enriched with droplet liquid, off the sample support, thereby exposing the microorganism sediments that are depleted of liquid; and (v) preparing the exposed microorganism sediments for spectrometric measurement, by means of infrared spectrometry or MALDI time-of-flight mass spectrometry, for example.

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• C12Q 1/18 - Testing for antimicrobial activity of a material

Abstract

The invention relates to the operation of an energy-focusing and solid-angle-focusing reflector for time-of-flight mass spectrometers with pulsed ion acceleration into a flight tube, e.g. from an ion source with ionization by matrix-assisted laser desorption (MALDI). The objective of the invention is to generate high mass resolution in wide mass ranges up to high masses above eight kilodaltons by varying at least one operating voltage on one of the diaphragms of the reflector which can be varied according to a suitable time function during the spectrum acquisition. It may also be advantageous to adapt the operation of the accelerating voltages in the starting region of the ions accordingly. These measures make it possible to achieve a mass resolution much higher than R=100,000 in a wide mass range extending up to and above eight kilodaltons.

IPC Classes  ?

• H01J 49/40 - Time-of-flight spectrometers
• H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components