This disclosure includes wound dressings and systems with remote oxygen generation for topical wound therapy and related methods. Some systems include a dressing for facilitating delivery of oxygen to the target tissue, the dressing having: a first manifold that defines a plurality of gas passageways and is configured to allow communication of oxygen to the target tissue; a gas-occlusive layer configured to be disposed over the first manifold and coupled to tissue surrounding the target tissue such that: an interior volume is defined between the gas-occlusive layer and the target tissue; and the gas-occlusive layer limits escape of oxygen from the interior volume between the gas-occlusive layer and the tissue surrounding the target tissue; a container outside the interior volume, the container having a sidewall that defines a chamber configured to be in fluid communication with the interior volume; and an oxygen-generating material disposed within the chamber of container and configured to release oxygen when exposed to water.
A61F 13/05 - Bandages or dressingsAbsorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A wound dressing comprising: a backing sheet; a layer of pressure-sensitive adhesive on the backing sheet; an island of absorbent material having smaller area than the backing sheet and applied onto a central region of the backing sheet so as to leave a margin of adhesive- coated backing sheet around the absorbent material, and an apertured wound facing layer applied over the absorbent material and adhered to the backing sheet around said island by said pressure-sensitive adhesive, wherein the apertured wound facing layer comprises an apertured substrate having a coating of a silicone gel on the wound facing surface thereof, the open area of the apertured wound facing layer is from about 5% to about 75%, and the apertured wound facing layer comprises apertures having an open area of from about 2 mm2 to about 100 mm2.
A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
The wound dressing described herein can be used as a contact layer dressing. The wound dressing can be positioned between a wound bed and a secondary dressing. The wound dressing can include a layered construction. Each of the layers can include a bioresorbable sponge enclosed within a collagen-based film. The wound dressing can include a plurality of fluid channels that enable fluid flow from the wound bed toward the environment-face side of the wound dressing.
A61F 13/05 - Bandages or dressingsAbsorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/32 - Proteins, polypeptidesDegradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
A61L 15/42 - Use of materials characterised by their function or physical properties
A61L 15/64 - Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
4.
ANTIMICROBIAL COMPOSITION, DRESSING, DRESSING COMPONENTS, AND METHOD
An antimicrobial composition may comprise a surfactant. The antimicrobial composition may include about 30 μg/ml to about 1,000 μg/ml of the surfactant, by volume of the antimicrobial composition. The surfactant may comprise a docusate salt such as docusate sodium. The antimicrobial composition may comprise an antimicrobial agent. The antimicrobial composition may include from about 0.01% to about 10% of the antimicrobial agent, by weight of the antimicrobial composition. The antimicrobial agent may comprise polyhexanide (PHMB). In some embodiments, the antimicrobial composition may comprise a matrix-forming material. The antimicrobial composition may include at least 90% of the matrix- forming material, by weight of the antimicrobial composition. The matrix-forming material may comprise collagen, oxidized regenerated cellulose, alginate, carboxymethylcellulose, or combinations thereof.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A dressing for wound healing is provided herein including dehydrated placental tissue, collagen, and oxidized regenerated cellulose. The dehydrated placental tissue may be present in a first layer and the collagen and the oxidized regenerated cellulose may be combined into a second layer. The dehydrated placental tissue may comprise amniotic membrane tissue, chorion tissue, or a combination thereof. The second layer including the collagen and the oxidized regenerated cellulose may comprise about 50% to about 60% collagen by weight and about 40% to about 50% ORC by weight.
A61L 15/32 - Proteins, polypeptidesDegradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
A61L 15/40 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof
The wound dressing described herein can be used as a contact layer dressing. The wound dressing can be positioned between a wound bed and a secondary dressing. The wound dressing can include a layered construction. Each of the layers can include a bioresorbable sponge enclosed within a collagen-based film. The wound dressing can include a plurality of fluid channels that enable fluid flow from the wound bed toward the environment-face side of the wound dressing.
A wound dressing includes a superabsorbent pad, a drape layer, a humidity chamber, a wick, and a humidity colorimeter sensor. The superabsorbent pad is configured to absorb wound fluid and has a first side and a second, wound- facing side. The drape layer is coupled to the first side of the superabsorbent pad and has a first side and a second, wound- facing side. The drape layer is substantially impermeable to liquid and substantially permeable to vapor. The humidity chamber is coupled to the first side of the drape layer opposite the superabsorbent pad. The wick extends through the drape layer and is configured to wick moisture between the superabsorbent pad and the humidity chamber. The humidity colorimeter sensor is located within the humidity chamber and configured to change color responsive to a humidity level within the humidity chamber.
The present disclosure describes a wound dressing that includes one or more antioxidants in the dressing's absorbent layer. In some implementations, the antioxidant includes green tea. The antioxidant containing wound dressing can both increase the absorbency of the dressing's foam and increase the cellular proliferation of the wound. With increased absorbency, the dressing can handle higher amounts of exudate compared to a hydropolymer foam without the green tea (or other antioxidant) addition. The cell proliferation component of the wound dressing described herein can decrease a wounds healing time, by increasing the cells proliferation and hence regenerating healthy skin faster.
A61L 15/40 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof
A61L 15/42 - Use of materials characterised by their function or physical properties
A61L 15/60 - Liquid-swellable gel-forming materials, e.g. super-absorbents
A dressing configured to be positioned adjacent to a tissue site is disclosed herein. The dressing may include oxidized regenerated cellulose (ORC), collagen, and at least one nutrient including glutamine. Methods of treating a tissue site are also disclosed herein.
A wound dressing includes an inelastic absorbent layer, an elastic film, and a plurality of welds. The inelastic absorbent layer is configured to absorb wound fluid and has a first side and a second, wound-facing side. The elastic film is configured to elastically stretch when a stretching force is applied to the wound dressing and elastically recover when the stretching force is removed. The plurality of welds fix the elastic film to the first side of the inelastic absorbent layer such that the elastic film and the inelastic absorbent layer elastically stretch and elastically recover as a unit.
This disclosure includes wound dressings and systems with remote oxygen generation for topical wound therapy and related methods. Some systems include a dressing for facilitating delivery of oxygen to the target tissue, the dressing having: a first manifold that defines a plurality of gas passageways and is configured to allow communication of oxygen to the target tissue; a gas-occlusive layer configured to be disposed over the first manifold and coupled to tissue surrounding the target tissue such that: an interior volume is defined between the gas-occlusive layer and the target tissue; and the gas-occlusive layer limits escape of oxygen from the interior volume between the gas-occlusive layer and the tissue surrounding the target tissue; a container outside the interior volume, the container having a sidewall that defines a chamber configured to be in fluid communication with the interior volume; and an oxygen-generating material disposed within the chamber of container and configured to release oxygen when exposed to water.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A biomaterial that includes collagen and an antimicrobial agent such as citric acid is provided herein. The biomaterial may further include a metal, such as silver, and an anionic polysaccharide, such as oxidized regenerated cellulose (ORC). Methods of using the biomaterial in wound therapy and on medical implants, and methods for preparing the biomaterial are also disclosed herein.
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
A61L 15/20 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/42 - Use of materials characterised by their function or physical properties
The technology described in this application provides a dressing (as well as uses, systems, and methods including such dressing) that includes a contact layer with a first surface configured to contact a tissue site in a subject and includes a scaffold configured to structurally support the contact layer, where the contact layer includes a bioresorbable material. The dressing may advantageously exhibit protease-modulating activity under physiological conditions.
The wound dressing described herein includes a backing layer, absorbent layer, and foam layer. The wound dressing also includes one or more visual indicators. The visual indicators are substantially non-visible in their initial, dehydrated state. As the visual indicators absorb fluid they swell and become visible. The visual indicators enable a caregiver to know when the wound dressing has reached, or is about to reach, its fluid capacity.
Described herein are wound dressings comprising: an absorbent layer capable of absorbing a given volume of fluid and comprising a first sorption zone comprising a first density of fibers and a second sorption zone comprising a second density of fibers higher than the first density; a hydrophilic foam layer coupled to the absorbent layer; and a backing layer extending beyond the absorbent layer and the hydrophilic foam layer to define a backing layer margin, wherein, upon exposure of the absorbent layer to a saturation threshold of wound exudate, the first sorption zone expands to a first thickness and the second sorption zone expands to a second thickness that is visually distinguishable from the first thickness. Methods of manufacturing the wound dressing and of eliminating, minimizing, or reducing edema are also described herein.
A61F 13/42 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators with wetness indicator or alarm
16.
WOUND DRESSING WITH ODOR ABSORPTION AND INCREASED MOISTURE VAPOR TRANSMISSION
A wound dressing includes a superabsorbent layer, a backing layer, and a charcoal layer. The superabsorbent layer is configured to absorb wound fluid and has a first side and a second, wound-facing side. The backing layer also has a first side and a second, wound-facing side. The backing layer is substantially impermeable to liquid and substantially permeable to vapor. The charcoal layer is positioned between the first side of the superabsorbent layer and the second, wound-facing side of the backing layer. The charcoal layer is configured to increase a moisture vapor transmission rate of the wound dressing.
Described herein is a wound dressing comprising: a composite island configured to collectively exhibit substantially elastic recovery under wound treatment conditions and comprising a foam layer and an absorbent layer coupled to the foam layer, the foam layer exhibiting substantially elastic recovery under wound treatment conditions and the absorbent layer not exhibiting substantially elastic recovery under wound treatment conditions; a backing layer having a margin that extends beyond the composite island; and an adherent layer disposed on at least the margin of the backing layer. In addition, described herein is a method of eliminating, minimizing, or reducing edema for a wound surrounded by tissue, by positioning the wound dressing over the wound, optionally such that at least a portion of the adherent layer contacts the tissue.
Described herein are dressings comprising a composite island comprising a polyurethane or foam layer coupled to an absorbent layer comprising non-woven gelling fibers. Also described herein are dressings comprising an absorbent layer comprising carboxymethyl cellulose fibers and a backing layer coupled to the absorbent layer. In the respective dressings, the absorbent layer is not elastically deformable under tissue treatment conditions, whereas the polyurethane or foam layer and the backing layer are substantially elastically deformable under tissue treatment conditions. The coupling of the absorbent layer to the polyurethane/foam layer or backing layer renders the coupled structure or the entire dressing substantially elastically deformable under tissue treatment conditions. Methods of eliminating, minimizing, or reducing edema are also described herein.
Described herein are dressings for incision management comprising a dressing layer that comprises: an elastic layer such as a hydrocolloid or foam layer; and an absorbent layer coupled, for example by lamination, to the elastic layer and which comprises: (i) from about 45% to about 90% carboxymethyl cellulose fibers; and (ii) from about 10% to about 55% elastic reinforcing fibers. Though the elastic layer may be substantially elastically deformable under tissue treatment conditions and the absorbent layer may be not elastically deformable under tissue treatment conditions, the coupling together of the elastic layer and the absorbent layer may result in a dressing layer, and advantageously a dressing, that is substantially elastically deformable under tissue treatment conditions. Methods for manufacturing such dressings and of eliminating, minimizing, or reducing edema using such dressings are also described herein.
Disclosed herein are dressings capable of filtering, capturing, and/or releasing select biological molecules from wound exudate. In one embodiment, the dressing may include a permeable, non-adherent envelope. The permeable, non-adherent envelope may enclose a composition comprising milled hydrophobic foam.
A substrate for transplanting a skin micrograft. The substrate may be configured to receive the tissue micrograft and be positioned at a recipient site. The substrate may have a first surface and a second surface, and may include a bioresorbable material and an adhesive. The bioresorbable material may include oxidized regenerated cellulose (ORC), for example, from about 40% to about 50% by weight of the substrate. The bioresorbable material may include collagen, for example, from about 50% to about 60% by weight of the substrate. The adhesive may include a sugar, for example, glucose from about 8% to about 16% by weight of the substrate. The bioresorbable material may include a plasticizer, for example, glycerol.
SYSTAGENIX WOUND MANAGEMENT IP CO. B.V. (Netherlands)
Inventor
Waite, Alexander
Delury, Craig
Cullen, Breda Mary
Abstract
Wound dressing compositions comprising oxidized regenerated cellulose and poly(hexamyethylene biguanide). The compositions preferably also contain a structural protein, such as collagen. Wound dressings are also provided, comprising an absorbent layer comprising the wound dressing compositions.
A backing sheet for use in a wound dressing includes a semipermeable continuous film laminated to an adhesive-coated apertured layer. The apertured layer is a solid substrate coated with a medically acceptable adhesive. A method of making a backing sheet for use in a wound dressing includes the steps of: forming an adhesive-coated apertured layer by coating a medically acceptable adhesive onto an apertured solid substrate, followed by laminating the adhesive-coated apertured layer to a semipermeable continuous film.
A wound dressing comprising: an air-impermeable backing sheet having an aperture for attachment of a suction element; an air-permeable screen layer on a wound facing side of the backing sheet; and a substantially air-impermeable hydrogel layer extending across a wound facing side of said screen layer and joined in substantially airtight fashion to a periphery of said backing sheet around said screen layer. Also provided is a wound treatment system comprising a wound dressing according to the invention and a source of suction in fluid communication with said aperture.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
Wound dressing compositions comprising: carboxymethyl cellulose, oxidized regenerated cellulose (ORC), and silver. The dressings optionally further comprise non- gelling cellulose fibers. The compositions may comprise a complex of the ORC and silver. Wound dressings are also provided, comprising an absorbent layer comprising the wound dressing compositions.
A silver-containing tissue dressing for providing antimicrobial properties to a wound site is disclosed. In some embodiments, the tissue dressing may include a wound contact layer having a substrate material coated with a tacky hydrophobic silicone material, and silver- containing particles dispersed in the silicone material. The different surfaces of the substrate material may be coated with the silicone material having various amounts of tackiness, The silver material may provide antimicrobial properties when the tissue dressing is placed in contact with the wound site.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A wound dressing comprising: a water-absorbent fabric comprising at least about 10 wt. % of hydrogel-forming absorbent fibers based on the dry weight of the fabric; and an adhesion-resistant, water-permeable wound contacting surface textile layer that is substantially continuously bonded to at least one surface of said fabric. The surface textile layer may be formed by surface treatment of the fabric, or by bonding a suitable textile web to the surface of the fabric.
A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
An adhesive dressing that reduces the leakage of wound exudate from the dressing, comprising an adhesive-coated backing sheet; and an absorbent island adhered to said adhesive-coated backing sheet by said adhesive, having a first end and a second end, wherein the absorption capacity of the absorbent island is higher at the first end than at the second end. The adhesive dressing of the invention provides extended wear time for the dressing when it is applied to wounds.
A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
A wound dressing comprising: an air-impermeable backing sheet having an aperture for attachment of a suction element; an air-permeable screen layer on a wound facing side of the backing sheet; and a substantially air-impermeable hydrogel layer extending across a wound facing side of said screen layer and joined in substantially airtight fashion to a periphery of said backing sheet around said screen layer. Also provided is a wound treatment system comprising a wound dressing according to the invention and a source of suction in fluid communication with said aperture.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
A solid wound dressing material comprising: at least about 5 wt % collagen; from about 6 wt % to about 9 wt % polyvinylpyrrolidone triiodide (PVP-I); and from 0 wt % to about 20 wt % water; wherein the weight percentages are based on the dry weight of the composition. Also provided are methods of making such materials, and wound dressings comprising such materials. In another aspect the invention provides a solid wound dressing material comprising: at least about 5 wt % collagen; from about 10 wt % to about 90 wt % Cadexomer iodine; and from 0 wt % to about 20 wt % water, wherein the weight percentages are based on the dry weight of the composition. Also provided are wound dressings comprising the materials.
A wound dressing composition comprising a non-viable cell lysate or releasate derived from a hepatocyte cell or an inflammatory cell such as a macrophage. Also provided are wound dressings comprising such compositions, methods of making such compositions, and the use of such compositions for the treatment of wounds.
A61L 15/40 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof
A61L 15/64 - Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
Use of a moulding composition comprising a polymer and a setting agent for wound debridement, wherein said use comprises adding water to said moulding composition to form a moulding fluid, applying said moulding fluid to a surface of a wound, allowing said moulding fluid to set in contact with said surface to form a solid covering on said surface, followed by removing said solid covering from the wound. The alginate composition adheres strongly to bacterial biofilms on the wound, whereby the biofilms are removed with the alginate composition. The moulding composition may be used in conjunction with a staining agent that undergoes a color change in the presence of bacteria or bacterial polysaccharides to show the presence and removal of the biofilm. Also provided are methods of treating wounds using the compositions.
A method of applying a patterned coating of a silicone adhesive to a substrate sheet, comprising the steps of pattern coating a silicone precursor composition onto the substrate, followed by thermally curing the precursor composition coated on the substrate. The precursor composition is a viscous fluid, and the pattern coating is performed by suitably modified block printing, intaglio printing or screen printing methods. Also provided are coated substrates obtainable by the methods of the invention, and wound dressings comprising such coated substrates.
B05D 1/28 - Processes for applying liquids or other fluent materials performed by transfer from the surfaces of elements carrying the liquid or other fluent material, e.g. brushes, pads, rollers
C09J 5/06 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving heating of the applied adhesive
A wound dressing product comprising: a substrate layer having an upper surface and a lower surface; a tacky silicone coating composition present on said upper surface and on said lower surface; and upper and lower release sheets covering said substrate and said tacky silicone coating composition on said upper and lower surfaces, respectively, and adhered to said surfaces by said tacky silicone coating composition, wherein said upper surface is less tacky than said lower surface whereby said upper release sheet can be removed from said upper surface more readily than said lower release sheet can be removed from said lower surface. The same silicone composition is used to form both the upper and the lower surface. Also provided are methods for making such dressings.
A wound dressing comprising: an air-impermeable backing sheet having an aperture for attachment of a suction element; an air-permeable screen layer on a wound facing side of the backing sheet; and a substantially air-impermeable hydrogel layer extending across a wound facing side of said screen layer and joined in substantially airtight fashion to a periphery of said backing sheet around said screen layer. Also provided is a wound treatment system comprising a wound dressing according to the invention and a source of suction in fluid communication with said aperture.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
A wound dressing material comprising: a wound dressing carrier, N-acetyl cysteine or a salt or derivative thereof, and a stabilized ascorbate. Suitably, the stabilized ascorbate comprises an ascorbate-2-polyphosphate. Also provided are wound dressing comprising the materials, methods of treatment with the materials, and methods of making the materials.
A61L 15/16 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
A61L 15/00 - Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
A wound dressing material comprising a solid substrate having interstitial spaces therein, wherein said substrate is a hydrophilic open-cell foam material, and wherein said interstitial spaces are at least partially filled by a hydrophilic polyurethane foam different from said substrate foam material. Also provided is a method of making a porous wound dressing material comprising the steps of: providing a substrate of a solid hydrophilic first foam material; applying a fluid or gel polyurethane foam prepolymer mixture to at least one surface of said solid substrate; and curing said prepolymer in contact with said solid substrate.
A61L 15/42 - Use of materials characterised by their function or physical properties
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
41.
Debridement method using topical nitric oxide donor devices and compositions
The present invention relates to methods for removal of dead tissue from wounds or skin using topical nitric oxide donor devices and/or compositions. In one embodiment, the present invention relates to a transdermal patch device that is designed to deliver nitric oxide. In another embodiment, the present invention relates to one or more devices and/or compositions that are designed to deliver nitric oxide and optionally one or more other compounds, where such devices/compositions include, without limitation, bandages, layered bandages, adhesive bandages, transdermal patches, creams, ointments, or a any combination of two or more thereof.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A backing sheet for use in a wound dressing, comprising a semipermeable continuous film laminated to an adhesive-coated apertured layer, wherein the apertured layer comprises a solid substrate coated with a medically acceptable adhesive. Also provided is a method of making a backing sheet for use in a wound dressing, said method comprising the steps of: forming an adhesive-coated apertured layer by coating a medically acceptable adhesive onto an apertured solid substrate, followed by laminating the adhesive-coated apertured layer to a semipermeable continuous film.
A wound dressing composition comprising a non-viable cell lysate or releasate derived from a hepatocyte cell or an inflammatory cell such as a macrophage. Also provided are wound dressings comprising such compositions, methods of making such compositions, and the use of such compositions for the treatment of wounds.
A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
A23L 1/22 - Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes
A23L 1/277 - Removing colour by chemical reaction, e.g. bleaching
A23L 1/00 - Foods or foodstuffs; Their preparation or treatment (preservation thereof in general A23L 3/00)
A01N 43/08 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with oxygen as the ring hetero atom
A61L 15/64 - Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
A61L 15/42 - Use of materials characterised by their function or physical properties
A61L 15/40 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof
A wound dressing comprising: a water-absorbent fabric comprising at least about 10 wt. % of hydrogel-forming absorbent fibers based on the dry weight of the fabric; and an adhesion-resistant, water-permeable wound contacting surface textile layer that is substantially continuously bonded to at least one surface of said fabric. The surface textile layer may be formed by surface treatment of the fabric, or by bonding a suitable textile web to the surface of the fabric.
A61F 13/53 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators characterised by the absorbing medium
A61L 15/46 - Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
A method of treatment of a wound, said method comprising the step of injecting an effective amount of an oxygen-containing fluid into said wound at a location below a surface of said wound, said step of injecting being carried out through a conduit having one or more outlets for said fluid, wherein substantially all of said outlets are positioned below the surface of the wound during said step of injecting. Injection of oxygen directly into the wound tissue below the wound surface provides enhanced wound healing.
A wound dressing material for controlled activation of a wound healing therapeutic compound in the presence of a protease enzyme in a wound fluid, the material comprising: a medically acceptable polymer; a wound healing therapeutic agent; an inhibitor of the protease enzyme; and a linker group which is cleavable by the protease enzyme, wherein the activities of both the wound healing therapeutic agent and the inhibitor are increased by contacting the wound dressing material with a wound fluid containing the protease enzyme. For example, the enzyme may be a matrix metalloproteinase, the therapeutic agent may be a reactive oxygen scavenger, and the inhibitor may be a tissue inhibitor of metalloproteinase (TIMP).
A wound dressing composition comprising a chitosan and an oxidized cellulose. For example, the composition may be in the form of a sponge formed by freeze drying an aqueous dispersion of chitosan and oxidized regenerated cellulose (ORC). The composition is especially suitable for the treatment of chronic wounds.
A61L 15/00 - Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
patents
