Abstract

The present invention relates to a compound for inducing the expression of the anti-aging gene klotho and a preparation method therefor. The compound represented by Chemical Formula 1, according to the present invention, has an excellent effect of increasing the expression level of the klotho gene which is a gene associated with aging, and thus can be useful for a pharmaceutical composition, cosmetic composition or food composition for preventing skin aging, inhibiting cellular senescence or preventing, treating alleviating a vascular aging-induced disease or a renal disease.

IPC Classes  ?

• C07D 263/58 - BenzoxazolesHydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61P 9/12 - Antihypertensives
• A61P 13/02 - Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61Q 19/08 - Anti-ageing preparations
• C07D 263/60 - NaphthoxazolesHydrogenated naphthoxazoles

Abstract

The present invention relates to a composition for the prevention or treatment of neurodegenerative disease, comprising compounds that induce the expression of the anti-aging gene klotho. The compounds represented by Chemical Formula 1 according to the invention are highly effective in enhancing the expression of the Klotho gene, a gene associated with aging, and thus can be useful for a pharmaceutical composition or a food composition for the prevention, amelioration or treatment of neurodegenerative disease.

IPC Classes  ?

• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to a composition for the prevention or treatment of chronic kidney disease (CKD), comprising compounds that induce the expression of the anti-aging gene klotho. The compounds represented by Chemical Formula 1 according to the invention are highly effective in enhancing the expression of the Klotho gene, a gene associated with aging, and thus can be useful for a pharmaceutical composition or a food composition for the prevention, amelioration or treatment of CKD.

IPC Classes  ?

• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys

Abstract

The present invention relates the prevention or treatment of chronic kidney disease (CKD), comprising using compounds that induce the expression of the anti-aging gene klotho. The compounds are represented by the following chemical formula, or a pharmaceutically acceptable salt thereof, [Image disponible dans le document PDF, Image available in the PDF document] wherein $R^1$ and $R^2$ are each -H, or $C_{1-10}$ straight or branched alkyl. These compounds are highly effective in enhancing the expression of the Klotho gene, a gene associated with aging, and thus can be useful for a pharmaceutical composition or a food composition for the prevention, amelioration or treatment of CKD.

IPC Classes  ?

• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• C07D 263/58 - BenzoxazolesHydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• C07D 263/60 - NaphthoxazolesHydrogenated naphthoxazoles

Abstract

The present invention relates to a composition for preventing or treating a neurodegenerative disease, comprising a compound inducing the expression of an anti-aging gene Klotho as an active ingredient. A compound represented by formula 1, according to the present invention, has an excellent effect of improving the expression level of the Klotho gene, which is a gene associated with aging, and can be usefully employed as a pharmaceutical composition or food composition for preventing, ameliorating, or treating neurodegenerative diseases.

IPC Classes  ?

• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to the prevention or treatment of neurodegenerative disease, comprising using compounds that induce the expression of the anti-aging gene klotho. The compounds represented by the following chemical formula, or a pharmaceutically acceptable salt thereof, [Image disponible dans le document PDF, Image available in the PDF document] wherein $R^1$ and $R^2$ are each -H, or $C_{1-10}$ straight or branched alkyl. These compounds are highly effective in enhancing the expression of the Klotho gene, a gene associated with aging, and thus they can be useful for pharmaceutical compositions and/or food compositions for the prevention, amelioration or treatment of neurodegenerative disease.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to a composition for preventing or treating chronic kidney diseases (CKDs), comprising a compound that induces the expression of anti-aging gene klotho. The composition represented by chemical formula 1, according to the present invention, has the effect of improving the expression of a klotho gene, which is a gene associated with aging, and thus can be effectively used for a pharmaceutical composition or food composition for preventing, alleviating or treating CKDs.

IPC Classes  ?

• C07D 263/58 - BenzoxazolesHydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• C07D 263/60 - NaphthoxazolesHydrogenated naphthoxazoles
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a compound for inducing the expression of the anti-aging gene klotho and a production method therefor. The compound represented by chemical formula 1, according to the present invention, has an excellent effect of increasing the expression level of the klotho gene which is a gene associated with aging, and thus may be useful for a pharmaceutical composition, cosmetic composition or food composition for preventing skin aging, inhibiting cellular senescence or preventing, treating, alleviating vascular aging-induced diseases or kidney disease.

IPC Classes  ?

• C07D 263/56 - BenzoxazolesHydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
• C07D 263/58 - BenzoxazolesHydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• A61K 31/421 - 1,3-Oxazoles, e.g. pemoline, trimethadione
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61Q 19/08 - Anti-ageing preparations
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives