A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X-N-X-S/T (SEQ ID NO:1), wherein each X is the same or different and is any natural amino acid other than proline, wherein the process comprises reacting the protein or peptide with a polyisoprenyl pyrophosphate of formula (I), or a salt thereof, in the presence of PglB:
A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X-N-X-S/T (SEQ ID NO:1), wherein each X is the same or different and is any natural amino acid other than proline, wherein the process comprises reacting the protein or peptide with a polyisoprenyl pyrophosphate of formula (I), or a salt thereof, in the presence of PglB:
A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X-N-X-S/T (SEQ ID NO:1), wherein each X is the same or different and is any natural amino acid other than proline, wherein the process comprises reacting the protein or peptide with a polyisoprenyl pyrophosphate of formula (I), or a salt thereof, in the presence of PglB:
to produce the glycoconjugate comprising the protein or peptide having a saccharide [S1] linked to the asparagine in the sequence D/E-X-N-X-S/T (SEQ ID NO:1). Polyisoprenylpyrophosphates used as substrates in the biocatalytic process are also provided, as well as certain glycoconjugates.
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.
A method of determining operation of a deep brain stimulation (DBS) lead 102, 104 comprising a plurality of electrodes 106, 108 is provided. The method comprises detecting an electrophysical signal at two or more of the electrodes and deriving a value representative of the electrophysical signal at each electrode. The method further comprises comparing the derived values and calculating a mathematical function or ratio representative of the magnitudes of the derived values. The method additionally comprises, on the basis of the calculated mathematical function or ratio, evaluating whether all or a subset of the electrodes should be activated for DBS. The method may further comprise mathematically fitting the derived values. A system for determining operation of a deep brain stimulation (DBS) lead using the method is also provided.
The invention relates to identifying genomic sequences which are characteristic of an organism. The invention also relates to using the genomic sequences to distinguish the organism from other organisms.
G06F 19/18 - for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
G06F 19/22 - for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or Single-Nucleotide Polymorphism [SNP] discovery or sequence alignment
KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (Saudi Arabia)
Inventor
Edwards, Peter P
Kuznetsov, Vladimir L
Xiao, Tiancun
Slocombe, Daniel
Gonzalez-Cortes, Sergio
Al-Megren, Hamid
Aldawsari, Afrah
Alkinani, Mohammad
Abstract
The invention provides a process for producing hydrogen, which process comprises exposing a composition to electromagnetic radiation, which composition comprises at least one organic compound and a catalyst, wherein the at least one organic compound is selected from: hydrocarbons and compounds which comprise a hydrocarbyl group, and the catalyst comprises: a metal in elemental form; a metal compound other than a metal oxide; a non- metal in elemental form selected from B, C, Si, P, Ge, As, Sb and Te; or an inorganic compound of said non-metal other than an oxide of the non-metal. Compositions as defined above are also provided, as are uses of the compositions as hydrogen storage materials or for generating hydrogen. An electromagnetic activation system suitable for the rapid production of hydrogen from hydrocarbons is also provided, which system comprises: a reactor comprising a reaction cavity, which reactor is configured to receive, in the reaction cavity, a composition to be decomposed, and is configured to deliver hydrogen; and a source of electromagnetic radiation, suitable for exposing a composition in the reaction cavity to electromagnetic radiation and thereby effecting decomposition of the composition to produce hydrogen. Further provided is the use of electromagnetic activation system of the invention as defined above for generating hydrogen from a composition of the invention as defined above. A system for generating hydrogen is also provided, comprising (a) a composition of the invention; and (b) a source of electromagnetic radiation, for exposing the composition to electromagnetic radiation and thereby effecting decomposition of the at least one organic compound to produce hydrogen.
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
C01B 3/26 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of gaseous or liquid organic compounds of hydrocarbons using catalysts
A support apparatus for an ultrasound probe head, the support apparatus comprising a support arm, the support arm being adjustable and having an ultrasound probe head mount to receive an ultrasound probe head, the ultrasound probe head mount comprising a resilient holder to receive an ultrasound probe, and an actuator to controllably move the ultrasound probe head mount.
F16B 2/22 - Clips, i.e. with gripping action effected solely by the inherent resistance to deformation of the material of the fastening of resilient material, e.g. rubbery material
7.
METHOD FOR TREATMENT AND PROGNOSIS OF COLORECTAL CANCER
The invention relates to the treatment and prognosis of colorectal cancer, especially proximal colorectal cancer. It also relates to identifying patients with colorectal cancer who are likely to respond to therapy with an inhibitor of interleukin 22 signalling.
The present invention relates to a chromatographic process, which process comprises contacting a composition with a hydrophilic stationary phase, which composition comprises: a)one or more analytes; b)water; c)an organic solvent; and d)an ion-pairing reagent; wherein the concentration of the ion-pairing reagent in the composition is less than or equal to 50 mM. Also described is a hydrophilic interaction liquid chromatographic process, which process comprises contacting a hydrophilic stationary phase with a composition comprising one or more analytes and an ion-pairing reagent, wherein the concentration of the ion-pairing reagent is less than or equal to 50 mM. The invention also relates to a chromatographic process, which process comprises (i) contacting a composition with a hydrophilic stationary phase, which composition comprises: a) one or more analytes; b) water; c) an organic solvent; and d) an ion-pairing reagent; and (ii) a step of analysing the composition which has been contacted with the hydrophilic stationary phase by mass spectrometry, evaporative light scattering detection(ELSD), charged aerosol detection (CAD), fluorescence detection, refractive index detection, chemiluminescence detection, optical rotation detection, or electrochemical detection. Uses and an apparatus are also described.
G01N 30/34 - Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
A rotary DNA motor comprising a static element, a rotary element rotatably movable relative to the static element, a binding domain provided on one of the static element and the rotary element, and a binding component provided on the other of the static element and the rotary element, the binding component comprising a first DNA hairpin, the binding domain being connectable to the binding component to cause relative rotation of the rotary element and static element, the binding domain being releasable from the binding component by a release component.
Aberrations in stimulated emission depletion microscopy are corrected using an adaptive optics approach using a metric which combines both image sharpness and brightness. Light modulators (22,32) are used to perform aberration correction in one or more of the depletion path (10), the excitation path (12), or the emission path from sample to detector.
G02B 26/06 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the phase of light
G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
A controllable polarizer for terahertz radiation, the polarizer comprising a polarizer plate, the polarizer plate comprising a plurality of nanowires, and a control element, the control element including a light source, such that the control element is operable to illuminate the polarizer plate to selectively photoexcite the nanowires.
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
A display device comprises a plurality of pixels, each pixel having a portion (10) of a solid-state, phase-change material such as germanium-antimonium-telluride (GST) or vanadium dioxide, wherein the phase-change material can be reversibly brought into an amorphous state or a crystaline state and has a refractive index that is reversibly, electrically controllable. A plurality of electrodes (14, 16) are provided, at least two of which contact said portion of material (10). A controller (19) is provided that is adapted to apply at least one voltage to said material (10), via said electrodes (14, 16), to change said refractive index. An array of such portions of material can be arranged to make a pixellated display, for example a stereoscopic display of the volumetric type.
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
G02F 1/19 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on variable-reflection or variable-refraction elements not provided for in groups
G02B 27/22 - Other optical systems; Other optical apparatus for producing stereoscopic or other three-dimensional effects
An optical device, such as an optical storage medium,comprises a layer of material in the solid state that has a refractive index that is switchable between at least two stable values by applied light. A reflector is spaced apart from the layer of material by a solid spacer layer transmissive to light.
G11B 7/243 - Record carriers characterised by the selection of the material of recording layers comprising inorganic materials only, e.g. ablative layers
A compound which is a pyridine or isoquinoline derivative of formula (I), or a pharmaceutically acceptable salt thereof, which is useful in the inhibition of γ- butyrobetaine hydroxylase (BBOX). The compounds are particularly useful in treatment of cardiovascular disease and diabetes. (I)
Methods of manufacturing a substrate unit that achieve improved levels of efficiency and/or longevity are disclosed. The substrate units may be used for example in solar cells, semiconductor detectors or electrostatic actuators, sensors, harvesters or other electro-mechanical devices. Disclosed methods include the steps of generating, or redistributing into the bulk of the dielectric film, a region of net charge in the dielectric film while the dielectric film is at a temperature greater than 150°C.
H01L 31/068 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN homojunction type, e.g. bulk silicon PN homojunction solar cells or thin film polycrystalline silicon PN homojunction solar cells
16.
RECONFIGURABLE ARRAY OF ELECTRICITY GENERATING CELLS FOR CHARGING A BATTERY
A system (400) comprising a reconfigurable array of electricity generating cells (302) for charging a battery (410); an array switching means for dynamically reconfiguring the array; a means for DC-DC conversion (312) of an array output voltage; and a means for altering the DC-DC conversion; wherein both the array switching means for array configuration and the means for altering the DC-DC conversion are modified in dependence on a battery terminal voltage.
Biomarkers are provided herein that are useful in predicting patient responses to treatment of disease, and to related assays using those biomarkers. Biomarkers provided herein are capable of identifying patients who will benefit from treatment with IGF-1R inhibitors.
A method of automatic speech recognition, the method comprising the steps of receiving a speech signal, dividing the speech signal into time windows, for each time window, determining acoustic parameters of the speech signal within that window, and identifying speech features from the acoustic parameters, such that a sequence of speech features are generated for the speech signal, separating the sequence of speech features into a sequence of phonological segments, and comparing the sequential phonological segments to a stored lexicon to identify one or more words in the speech signal.
The present invention relates to devices comprising metal halide perovskites and organic passivating agents. In particular, the invention relates to photovoltaic and optoelectronic devices comprising passivated metal halide perovskites. The device according to the invention comprises: (a)a metal halide perovskite; and (b) a passivating agent which is an organic compound; wherein molecules of the passivating agent are chemically bonded to anions or cations in the metal halide perovskite. The invention also provides aprocess for producing a photovoltaic device, which photovoltaic device comprises: (a) a metal halide perovskite; and (b) a passivating agent which is an organic compound; wherein molecules of the passivating agent are chemically bonded to anions or cations in the metal halide perovskite, wherein theprocess comprises treating a metal halide perovskitewith a passivating agent, which passivating agent is an organic compound and is suitable for chemically bonding to anions or cations in the metal halide perovskite.
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
An adaptor (19) for a microscope, the adaptor comprising a support part (11) to be received in an accessory slot of a microscope, a light source element (12) and a mirror (13) located on the support part to receive light from the light source element.
A method of controlling interactions between fluid compartments in a fluid flow, comprising providing a first phase within a fluid conduit; enclosing within the first phase a separating compartment of a second phase that is immiscible with the first phase; providing at least one reagent compartment of a third phase that is immiscible with the second phase; and arranging the compartments such that at least one of the separating compartment and the at least one reagent compartment has a length equal to or greater than the conduit diameter.
G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
B01F 13/00 - Other mixers; Mixing plant, including combinations of dissimilar mixers
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
A sensor comprising a resonator, the resonator compromising a body supported at at least two points, the resonator comprising a graphene sheet, the sensor further comprising a detection circuit responsive to piezoresistive changes in the resonator.
The invention relates to the use of a molecular adjuvant to generate an improved immune response in a host. Over recent years extensive research and development has been undertaken in the development of "vectored vaccines" which can be used as vaccine delivery systems. Vectored vaccines include DNA vectors and recombinant viral and bacterial vectors, which are engineered to express an antigen of interest. The invention provides a nucleic acid construct encoding a protein fusion between an antigen and an invariant chain molecule.
Disclosed herein is a method of (and a sensor for) determining the presence of and/or concentration of superoxide anions in a sample of interest, the method comprising: • (a) providing an electrically conducting substrate having on a surface thereof a paste comprising an organic liquid binder and electrically conductive particles dispersed in the binder, contacting the paste with the sample of interest, wherein, if superoxide anions are present in the sample of interest, at least some of the superoxide anions are incorporated within the paste, wherein a first species is present within the paste at the time of contacting the paste with the sample of interest or a first species is incorporated into the paste after the contacting of the paste with the sample of interest, the superoxide anions then reacting with the first species to form a second species, • (b) using the electrically conducting substrate, having on a surface thereof the paste, produced in step (a) as a working electrode in an electrochemical test that involves altering the potential at a working electrode to a potential at which the first and/or second species is oxidised or reduced and obtaining electrochemical information, • (c) using the electrochemical information to determine the presence of and/or concentration of superoxide anions in the sample of interest.
The invention disclosed herein relates to a nanoparticle comprising: a cup having a cavity, and a gas pocket present in the cavity, wherein the gas pocket is partially encapsulated by the cup. Typical uses of the nanocups include initiating inertial cavitation during simultaneous exposure to ultrasound, and/or as drug carriers to achieve targeted drug delivery in response to ultrasound excitation.
A fluorogenic compound comprising a biologically active component and a hypoxia- activated protecting group which is fluorogenic. The biologically active component is bound to the fluorogenic component at an active binding position such that activity of the biologically active compound is suppressed until the protecting group is released. The protecting group is cleaved under hypoxic conditions, releasing the active compound and a fluorescent compound. The compounds can therefore be used in the treatment of hypoxia- related disease and disorder, such as tumour, and enable imaging of the release of the biologically active compound.
A computer-implemented method of providing a materialisation of a set of logical rules on a logical database comprising a set of logical facts. Each of a plurality of parallel processing threads performs the following steps. A logical fact that has not previously been received by any thread is received by the thread. By applying any of the logical rules to the received logical fact and/or any of the logical facts received by any thread prior to the received logical fact, the thread determines whether a new logical fact is implied, and if so the new logical fact is added to the set of logical facts. The thread then repeats the above steps on any further logical facts in the set of logical facts that have not previously been received by any thread. When all threads are waiting for a new logical fact, the method has completed.
The present invention provides a shielded biologic therapeutic comprising a biologic therapeutic which is covalently and cleavably bound to one or more nanoparticle, with a plurality of polymer chains bound to the or each nanoparticle.
The invention disclosed herein relates to a method of cavitation-induced delivery of a therapeutic or diagnostic agent to a human or animal subject. In particular the invention provides an agent for use in a method of diagnosis or treatment of a human or animal subject, the method comprising exposing the subject to ultrasound, wherein the agent comprises a therapeutic or diagnostic component which is covalently bound to a dense component, the dense component having a density greater than that of the therapeutic or diagnostic component, and wherein either the dense component is a cavitation initiator or the method comprises administering to the subject a further agent which is a cavitation initiator. Binding of the dense component enhances cavitation-induced transport of the therapeutic or diagnostic component.
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
An ion trap comprising a plurality of electrodes and a power supply arranged to provide an alternating current to said electrodes to create a time varying electric field capable of trapping two or more species of ion between the electrodes, wherein the power supply is arranged to provide an alternating current drive signal comprising a first lower frequency component suitable for trapping a first ion species and simultaneously a second higher frequency component suitable for trapping a second ion species, and wherein the first and second frequency components are selected such that the frequency of oscillation of the centre of mass of the lighter trapped ion is greater than the frequency of the drive signal component for trapping the heavier ion. The use of two frequency components to trap two species of ion in this way allows greater interaction between the two species, in turn allowing visualisation and/or investigation of the heavier ion. This is of particular benefit for examination of large and heavy molecules such as biomolecules.
A compact microscope comprising an enclosure, a support element, a primary optical support element located within the enclosure and supported by the support element, at least one vibration isolating mount between the support element and the primary optical support element, an illumination section, an objective lens system, a sample stage mounted on the primary optical support element, an illumination optical system to direct an illumination light beam from the illumination section to the sample stage, and a return optical system to receive returned light from sample stage and transmit returned light to a detection apparatus, wherein the illumination optical system and return optical system are mounted on the primary optical support element.
The invention relates to a pressure sensor, particularly for use at extremely high temperatures and/or pressures. In a disclosed embodiment, the pressure sensor is configured to measure the pressure in a test environment and comprises: a housing comprising a chamber that is sealed from the test environment; a force-transmitting element comprising an outer surface and an inner surface, the outer surface being exposed directly to the test environment and the inner surface being arranged to face into the chamber, the force- transmitting element being slidably mounted within the housing so that a force applied to the outer surface is transmitted to the inner surface; a sensor element mounted in the chamber and configured to receive a force transmitted by the force-transmitting element via the inner surface of the force-transmitting element; and a measurement system configured to measure a change of a dimension of the sensor element and/or of a dimension of a region within the sensor element, caused by the force transmitted thereto by the force- transmitting element, thereby providing a measure of the pressure in the test environment
G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elementsTransmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
G01L 23/12 - Devices or apparatus for measuring or indicating or recording rapid changes, such as oscillations, in the pressure of steam, gas, or liquidIndicators for determining work or energy of steam, internal-combustion, or other fluid-pressure engines from the condition of the working fluid operated electrically by changing capacitance or inductance
G01L 23/16 - Devices or apparatus for measuring or indicating or recording rapid changes, such as oscillations, in the pressure of steam, gas, or liquidIndicators for determining work or energy of steam, internal-combustion, or other fluid-pressure engines from the condition of the working fluid operated electrically by photoelectric means
G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X-N-X-S/T, wherein each X is the same or different and is any natural amino acid other than proline, wherein the process comprises reacting the protein or peptide with a polyisoprenyl pyrophosphate of formula (I), or a salt thereof, in the presence of PglB: (I) to produce the glycoconjugate comprising the protein or peptide having a saccharide [SI] linked to the asparagine in the sequence D/E-X-N-X-S/T. Polyisoprenylpyrophosphates used as substrates in the biocatalytic process are also provided, as well as certain glycoconjugates.
C07K 9/00 - Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequenceDerivatives thereof
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
ACADEMISCH ZIEKENHUIS LEIDEN (ALSO ACTING UNDER THE NAME OF LEIDEN UNIVERSITY MEDICAL) (Netherlands)
Inventor
Longley, Rhea
Salman, Ahmed
Spencer, Alexandra
Hill, Adrian
Janse, Chris
Khan, Shahid
Abstract
The invention relates to an antigenic composition or vaccine comprising a viral vector, the viral vector comprising nucleic acid encoding Plasmodium protein Pf LSA1, or a part or variant of Plasmodium protein PfLSA1; PfLSAP2, or a part or variant of Plasmodium protein PfLSAP2; PfUIS3, or a part or variant of Plasmodium protein PfUIS3; PfI0580c, or a part or variant of Plasmodium protein PfI0580c; and PfSPECT-1, or a part or variant of Plasmodium protein Pf SPECT-1.
A fuel cell comprising: a cavity; an electrochemically active assembly located within the cavity, at least a portion of the electrochemically active assembly being capable of absorbing microwave radiation; a microwave applicator comprising a source of microwave radiation and a waveguide arranged to transmit microwave radiation generated by the source of microwave radiation into the cavity;wherein the cavity is configured such that, in use, for a given microwave frequency, a desired microwave field configuration is produced within the cavity, the desired microwave field configuration being selected such that at least a portion of the electrochemically active assembly is selectively heated.
A scaffold for tissue repair or wound dressing comprising: a material layer;a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.
Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.
A delivery system for a biocide, wherein: the delivery system comprises a core material(which may be porous or substantially non-porous); a biocide is located within or on the core material; and the delivery system further comprises a capping material applied to the core material so as to contain the biocide within or on the core material, and to enable exposure (e.g. release) of the biocide when the capping material is broken down or opened up. Methods of designing and/or manufacturing such a delivery system and of delivering biocides are also provided, as are examples of products embodying the delivery system.
A01N 35/02 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio-analogues thereofDerivatives thereof, e.g. acetals
A01N 47/46 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=C=S groups
A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
The invention relates to a method of measuring turbulence in a high temperature fluid flow, comprising: applying different levels of cooling at different times to a region of a substrate in the high temperature fluid flow; and/or applying different levels of cooling at the same time to different regions of a substrate in the high temperature fluid flow and/or to regions on different substrates in the high temperature fluid flow, wherein the method further comprises: measuring fluctuations in the temperature of the region or regions of the substrate or substrates at each of the different levels of cooling;and using the measured fluctuations to determine an amount of turbulence in the high temperature fluid flow and/or the size of temperature fluctuations in the high temperature fluid flow.
G01P 5/10 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring thermal variables
G01P 13/00 - Indicating or recording presence or absence of movementIndicating or recording of direction of movement
G01F 1/68 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using thermal effects
A method for producing a continuous filament from electrospun fibres uses a conducting collection surface that is an elongate, three-dimensional surface, such as a moving wire (2). An attractive electric field gradient is formed between the collection surface of the wire (2) and a source (16) of electrically charged fibres (14). The collection surface of the wire (2) is moving in a longitudinal direction relative to the source (16) of electrically charged fibres. The fibres are collected on the surface of the wire (2) so as to form a continuous filament (24). The filaments (24) can then be stretched and assembled into multifilament yarns which imitate the hierarchical structure of tissues such as tendons and ligaments.
The invention relates to a new method of determining the presence, absence, number or position(s) of one or more post-translational modifications in a peptide, polypeptide or protein. The invention uses transmembrane pores.
Waveguide A waveguide for carrying waves by inductive coupling comprises a plurality of resonant5 elements, the plurality of resonant elements including a first resonant element; a second resonant element; and a coupling section capacitively coupling the first and second resonant elements, wherein the coupling between the first and second elements produces a first pass- band and a second-pass band, different from the first pass-band, the first pass-band being associated with the resonance of the resonant elements and the second pass-band being10 associated with resonance of the coupling section. Figure 3 15
UNIVERSIDADE ESTADUAL PAULISTA "JÚLIO DE MESQUITA FILHO" - UNESP (Brazil)
Inventor
Davis, Jason
Bueno, Paulo Roberto
Abstract
Capacitance spectroscopic method and electrode The application relates to methods and electrodes for electrochemical detection of target species by capacitance spectroscopy. The method is simple, frequency optimised and extremely sensitive to low concentrations of target species. The electrodes of the invention can easily be reused and are ideally suited for use in point-of-care diagnostics.
A carrier to which is attached a peptide and DNA encoding the peptide, wherein the peptide includes at least one non-natural amino acid and/or wherein the peptide has a constrained secondary structure; or a carrier to which is attached β2 microglobulin, a peptide, and DNA encoding the peptide, said carrier not bearing an MHC or MHC-like molecule.
The invention relates to a method of producing a preparation of membrane vesicles comprising one or more membrane proteins, and to related methods, preparations and compositions.
A method of training a neural network having at least an input layer, an output layer and a hidden layer, and a weight matrix encoding connection weights between two of the layers, the method comprising the steps of (a) providing an input to the input layer, the input having an associated expected output, (b) receiving a generated output at the output layer, (c) generating an error vector from the difference between the generated output and expected output, (d) generating a change matrix, the change matrix being the product of a random weight matrix and the error vector, and (e) modifying the weight matrix in accordance with the change matrix.
The present invention provides processes for the production of chiral compounds in a stereoisomeric excess, the processes comprising: (i) contacting a first compound comprising an alkene or alkyne bond with a hydrometallating agent, wherein the first compound and the hydrometallating agent are contacted under conditions such that the first compound is hydrometallated by said hydrometallating agent; and (ii) contacting the hydrometallated first compound with a second compound comprising an allylic group, wherein the hydrometallated first compound and the second compound are contacted under conditions such that they undergo an asymmetric allylic alkylation reaction in which a carbon atom of the hydrometallated first compound binds to a carbon atom of said allylic group, forming a stereoisomeric excess of a compound having a chiral centre in an allylic position, said chiral centre being located at the carbon atom bound by said first compound, wherein said asymmetric allylic alkylation reaction is performed in the presence of a metal catalyst comprising a chiral ligand. In particular, the present invention provides processes for the production of a stereoisomeric excess of a compound of the formula (IA), (IB), (IA') or (IB') as defined herein.
C07C 2/86 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by condensation between a hydrocarbon and a non-hydrocarbon
This invention relates to a method of identifying a compound useful in modulating Notch signalling. In particular, it relates to a method of identifying an antibody or a phospholipid mimic useful in modulating Notch signalling. It also relates to novel agents, including novel antibodies or phospholipid mimics, useful in modulating Notch signalling for use in medicine, and the treatment of cancer in particular.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The present invention relates to therapeutic compounds useful for the treatment of neurodegenerative and neuromuscular diseases and/or triplet repeat diseases (e.g. Friedreich's ataxia). The compounds have the structural formula I shown below: wherein Q, X, p, R1, q, R3 and R4 are as defined herein. The present invention also relates to pharmaceutical compositions comprising the compounds defined herein, the use of these compositions for the treatment of neurodegenerative and neuromuscular diseases and/or triplet repeat diseases (e.g. Friedreich's ataxia), and to processes for the preparation of the pharmaceutical compositions defined herein.
A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61K 31/54 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
50.
HYDROXYCHLOROQUINE FOR THE TREATMENT OF CARDIOVASCULAR DISEASE
The present invention provides hydroxychloroquine or a pharmaceutically acceptable salt thereof for use in the prevention and/or treatment of systolic heart failure, diastolic heart failure, sinus tachycardia, cardiac syndrome X and/or essential hypertension.
A method of obtaining information about the rate of a periodic physiological process from a time series of measurements obtained from a patient, comprising: obtaining the time series of measurements; fitting a model defining a probability distribution over functions to the time series of measurements, wherein the model is defined by a mean function and a periodic covariance function; and outputting the result of the fitting as information about the rate of the periodic physiological process.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
The invention relates to processes for producing semi-transparent photoactive layers, and devices comprising the same. The invention provides a process for producing a semi- transparent photoactive layer comprising: a) disposing on a substrate a composition, which composition comprises a photoactive material or one or more precursors of a photoactive material, to form a resulting layer; and b) dewetting the resulting layer to form a dewet layer of the photoactive material, wherein the dewet layer of the photoactive material is semi-transparent. The invention also provides a semi-transparent photoactive layer comprising a substrate and, disposed on the substrate, a dewet layer of a photoactive material, wherein the dewet layer of a photoactive material comprises a plurality of absorbing regions which comprise the photoactive material and a plurality of transparent regions which do not substantially comprise the photoactive material. Devices and processes for producing devices comprising the semi-transparent layer are also disclosed, as are building components and automotive components comprising the semi-transparent layer.
H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
53.
METHOD OF DETECTING THE PRESENCE OR ABSENCE OF AUTOANTIBODIES
A charged particle scintillator (1), the scintillator comprising an organic luminescent dye(3) which,in use, serves to convert impinging charged particles into light and the scintillator comprises a base (2), and the luminescent dye deposited on the base.
G01T 1/20 - Measuring radiation intensity with scintillation detectors
G21K 4/00 - Conversion screens for the conversion of the spatial distribution of particles or ionising radiation into visible images, e.g. fluoroscopic screens
There is disclosed a cold head (2) for a pulse tube cooler, comprising: a regenerator (4) having a first end (6) connectable to a compressor; a pulse tube (14) having a first end (12) and a second end (16); a heat exchanger (10) connected between a second end of the regenerator and the first end of the pulse tube; and a phase control device (26) connected at the second end of the pulse tube for controlling the flow dynamics in the pulse tube to provide cooling at the heat exchanger, thereby maintaining a negative temperature gradient between the first and second ends of the regenerator, wherein: the pulse tube comprises a wall (15) having a porous portion (28) for allowing a working gas to enter or leave the pulse tube directly through the porous portion, the porous portion extends substantially parallel to the axis of the pulse tube.
F25B 9/14 - Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point characterised by the cycle used, e.g. Stirling cycle
There is provided a nucleic acid that inhibits miR-31 in an atrial myocyte, for use in the prevention or treatment of atrial fibrillation in a subject. Also provided is a method for diagnosing or predicting the risk of atrial fibrillation in a subject, said method comprising: (i) determining the amount of miR-31 in a sample from the subject; (ii) comparing the amount of miR-31 in the sample with a reference standard; and (iii) identifying a difference in the amount of miR-31 in the sample relative to the reference standard; wherein an increase in the amount of miR-31 in the sample compared to the reference standard correlates with the presence of, or an increased risk of, atrial fibrillation in the subject; and wherein a decrease, or no difference in the amount of miR-31 in the sample compared to the reference standard correlates with the absence of an increased risk of atrial fibrillation in the subject.
The present invention relates to the doping of organic semiconductors and processes for producing layers of p-doped organic semiconductors. Disclosed is a process for p-doping organic semiconductors comprising treating the organic semiconductor with an oxidised salt of the organic semiconductor. A process for producing a layer of a p-doped organic semiconductor comprising producing a p-doped organic semiconductor by treating the organic semiconductor with an oxidised salt of the organic semiconductor; disposing a composition comprising a solvent and the p-doped organic semiconductor on a substrate; and removing the solvent is also described. Also disclosed is a process for producing a layer of a p-doped organic semiconductor comprising: disposing a composition comprising a solvent, the organic semiconductor and a protic ionic liquid on a substrate; and removing the solvent. A process for producing a semiconductor device comprising a process for doping an organic semiconductor according to the invention is also described. Finally, a high purity p-dopant composition is described.
H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
The present invention relates to a method of determining the concentration of an anion selected from a halide ion and a pseudohalide ion in a sample of interest, the method involving: providing a working electrode having a substance in a first oxidation state on a surface thereof, wherein the electrode is in contact with the sample of interest that contains the anion; carrying out a voltammetry or chronoamperometry experiment that involves increasing the potential applied to the working electrode to a first potential to oxidise the substance to a second oxidation state, wherein, at the first potential, the electrochemical response of the substance is different when the anion is present in the sample compared to when the anion is absent in the sample, and obtaining electrochemical information during the voltammetry or chronoamperometry experiment; using a determined relationship between the electrochemical information and the concentration of the anion in a reference sample to calculate the concentration of the anion in the sample of interest. An apparatus for carrying out the method and use of an electrode having silver on a surface thereof are also disclosed herein.
The present invention relates to polypeptides, proteins and antibodies comprising a FcγRIIB-binding domain. The invention further relates to methods of suppressing immune cell activation or immuno-suppression, and particularly to methods of treating inflammatory and autoimmune disorders using such polypeptides, proteins and antibodies.
The present application provides a method of detecting nanoparticles in a sample comprising: a. immersion of a substrate in the sample, wherein, if the nanoparticles are present in the sample, at least some of the nanoparticles are immobilized on the substrate; b. analysing the substrate to determine the presence of, identity of the material of and/or quantity of the nanoparticles on the substrate and/or in the sample. A device for carrying out the method is also disclosed. In a preferred embodiment, silver nanoparticles (AgNPs) are detected in situ in the environment, eg. sea water, by immersing a cysteine modified glassy carbon (GC) electrode in a sample and detecting adsorbed silver using anodic stripping voltammetry (ASV).
G01N 27/42 - Measuring deposition or liberation of materials from an electrolyteCoulometry, i.e. measuring coulomb-equivalent of material in an electrolyte
G01N 27/48 - Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
B82Y 35/00 - Methods or apparatus for measurement or analysis of nanostructures
According to the present invention, there is provided a catalytic complex comprising a metal, one or more ligands and one or more counterions, wherein said one or more ligands include a non-racemic chiral ligand and wherein said one or more counterions include a triflimide counterion. Also provided are methods of making said catalytic complex and processes for producing chiral compounds which involve the use of said catalytic complex. In addition, the present invention provides compounds of the formula (2) as defined herein. The compounds of formula (2) may be useful as ligands in catalytic complexes.
A deployable structure, comprising: a first construction unit comprising a spacing module and a first flange module, wherein: the spacing module comprises first, second, third and fourth sheet units that are hinged together; the first flange module comprises fifth, sixth, seventh and eighth sheet units that are hinged together; and the spacing module and first flange module are connected together by hinges in such a way as to be switchable by rotation about the hinges between: a storage state in which the first to eighth sheet units are substantially coplanar; and a deployed state in which the first flange module is compressed in two orthogonal directions relative to the storage state.
A shell structure is disclosed that comprises one or more shell modules. The shell modules each comprise a core module and a face module. The core module comprises a plurality of planar core plates having a geometry that allows them to fold relative to each other when unconstrained from a flat state to an expanded state having curvature. The face module comprises a plurality of planar face plates that are connected together at non-zero angles relative to each other. When the structure is assembled, the core module is in the expanded state and at least one of the face plates is connected along a continuous line to a corresponding core plate on a radially inner or radially outer side of the core module.
E04C 2/32 - Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by the shape or structure formed of corrugated or otherwise indented sheet-like materialBuilding elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by the shape or structure composed of such layers with or without layers of flat sheet-like material
E04C 2/34 - Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by the shape or structure composed of two or more spaced sheet-like parts
The invention relates tobiomarkers for determining the prognosis of cancer patients. By determining the level of the biomarker HR23B in the cell or patient, and optionally determining the levels of one or more of the biomarkers HDAC6, LC3 and HSP90, the invention provides a method for determining the susceptibility of a cell or a patient of interest to entering an autophagocytic state upon treatment with a drug. The invention also provides a method of determining susceptibility of a cell or patient to treatment with a drug. Entering an autophagocytic state is thought to be a tumour cell survival mechanism, whereby the tumour cell avoids apoptosis. The methods of the invention may therefore be helpful for determining whether a patient should be treated and for determining the prognosis upon drug treatment.
The invention provides a sensor component for detecting an analyte, comprising a first electrode and a second electrode; an insulating substrate disposed between the first electrode and the second electrode; a plurality of conductive nodes disposed on a surface of the insulating substrate; and a plurality of connector molecules comprising two or more groups capable of forming a chemical bond with a conductive node or an electrode, which connector molecules are capable of displaying a change in an electrical property in response to interaction with an analyte. At least some of the connector molecules are bonded to one or more nodes, or to one electrode, and thereby form electrical junctions between separate nodes or between a node and an electrode. The electrical junctions form an electrical percolation network comprising at least one continuous pathway of connector molecules between conductive nodes which connects the first electrode and the second electrode. Preferably,the network is in the percolation region. The invention also relates to a process for producing a sensor component, and a sensor component obtainable by that process. The invention also provides devices comprising the sensor component of the invention, including a sensor, as well asuses of the sensor component of the invention and uses of the devices of the invention,for detecting analytes.
G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
The present invention provides a method of recovery of an undersampled low-rank Magnetic Resonance Imaging (MRI) dataset. The method comprises the steps of: undersampling the dataset; and employing an Iterative Hard Thresholding and Matrix Shrinkage (IHT+MS) algorithm, on the data set, to directly reconstruct the low-rank data set.
G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
A method of controlling a helicoidal liquid crystal material wherein the liquid crystal material has a negative dielectric anisotropy Δε satisfying Δε = εΜ - εχ < 0, where εΜ is the dielectric constant parallel to the helical axis of the liquid crystal material and ε± is the dielectric constant perpendicular to the helical axis of the liquid crystal material, such that in a state without flexoelectric coupling the material has a lowest energy alignment state in which the helical axis is aligned parallel to an applied electric field. The liquid crystal material can undergo flexoelectric coupling with an applied electric field as a result of an effective dielectric constant εeffective perpendicular to the helical axis given by εeffective = εflexo + (ε,, + ε⊥)/2 > ε⊥, where εflexo is a contribution from flexoelectric polarisation in the material, such that in a state with flexoelectric coupling the material has a lowest energy alignment state in which the helical axis is aligned perpendicular to an applied electric field. The method comprises applying an electric field to the material and changing one or more parameters of the electric field so as to enable or suppress said flexoelectric coupling and thereby switch the material between lowest energy alignment states in which the helical axis is aligned either perpendicular or parallel to the applied electric field.
G02F 1/137 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells characterised by the electro-optical or magneto-optical effect, e.g. field-induced phase transition, orientation effect, guest-host interaction or dynamic scattering
69.
METHODS OF MANUFACTURE OF ELECTRODES, SEPARATORS, AND ELECTROCHEMICAL ENERGY STORAGE DEVICES
A method of manufacture of an electrode having a non-uniform microstructure or mesostructure comprising: providing a first suspension containing a first electrode material and a second suspension containing a second electrode material; delivering the first and second suspension to a spraying means; operating the spraying means for a period of time to spray the first and second suspension on to a substrate located a distance from the spraying means; and controlling the mass flow rate of the first electrode material and/or the second electrode material to and/or through the spraying means as a function of time for at least a portion of the period of time.
GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (USA)
Inventor
Clarke, Kieran
Veech, Richard
King, Todd
Abstract
A process for the production of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate comprising: i) contacting poly-(R)-3-hydroxybutyrate with an alcohol to transesterify the poly-(R)-3-hydroxybutyrate under transesterification conditions to produce an ester of (R)-3-hydroxybutyrate and the alcohol; ii) separating the product of step i) into a first and second portion and reducing the first portion of the (R) 3-hydroxybutyrate ester to form (R)-1,3-butanediol; and iii) contacting under transesterification conditions the (R)-1,3-butanediol from step ii) with the second portion of the transesterified ester to produce (R)-3-hydroxybutyl-(R)-hydroxybutanoate.
C07C 67/03 - Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
C07C 29/147 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
C07C 69/675 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
The present invention provides an immunogenic composition capable of eliciting an immune response when administered to a human or non-human animal, wherein the composition comprises an isolated protein with one or more of the following properties: i)about 70, 75, 80, 85, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99 or more percent sequence identity to the protein of SEQ ID No: 1 or a fragment, derivative or analog thereof; ii)is a modified factor H binding protein, wherein the factor H binding protein has been modified at least at the position equivalent to position 318 as defined in Figure 6 (SEQ ID No: 2); iii)does not bind to factor H; and iv)the immune response elicited is cross reactive with two or more of variant 1 factor H binding protein, variant 2 factor H binding protein and variant 3 factor H binding protein from N. meningitidis; and uses thereof.
A method comprises detecting scintillation from a scintillator unit including a scintillator; and determining a temperature of the scintillator or a sample in thermal contact with the scintillator, based on the detected scintillation, wherein a majority of the detected scintillation is excited by a radiation source provided integrally with the scintillator. A scintillator unit, system and method of producing a scintillator system are also provided.
The present invention is concerned with prenatal screening and in particular non-invasive prenatal screening, as well as primers, primer sets and kits. In one instance, the invention provides a method of prenatal screening comprising: (a) amplifying a region encompassing the site of a mutation site responsible for the disorder, the amplification being performed on a DNA sample obtained from a pregnant female which comprises both maternal and fetal DNA; (b) sequencing a plurality of products from the amplification and determining whether or not the mutant allele is represented at a different frequency to that expected from the genotype of the pregnant female alone.
The present disclosure provides systems and methods which may assist in evaluating liver fibrosis/inflammation in the presence of elevated iron using magnetic resonance relaxometry. In a non-limiting embodiment, the systems and methods include: obtaining a measurement of relaxometry data of a subject's liver for extracellular fluid, preferably using a magnetic resonance imaging (MRI) device; determining an iron content for the liver; simulating a measurement of the subject's liver for extracellular fluid for the determined iron content; comparing the measurement of the subject's liver for extracellular fluid to the simulated measurement of the subject's liver for extracellular fluid; and determining from said comparison a value of extracellular fluid in the subject's liver based on a normal iron content for the liver. The simulation can include multi-compartment modeling of various fractions of extracellular fluid in the liver and the impact of iron content in the liver on both the intra- and extracellular relaxation times.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G01R 33/50 - NMR imaging systems based on the determination of relaxation times
75.
ASSAY METHOD FOR PARKISON'S DISEASE USING 14-3-3 THETA AS A MARKER
A method for the identification or monitoring of Parkinson's Disease (PD) in an individual, which method comprises measuring the level of at least one marker in a sample taken from the individual.
A method of producing a localised concentration of energy comprises: creating at least one shockwave (8) propagating through a non-gaseous medium (2) so as first to be incident upon a focusing pocket of fluid (4) within the medium (2). The focusing pocket of fluid (4) is positioned relative to a differently sized target pocket of gas (6) within the medium (2), and is arranged to shield the target pocket of gas (6) from the initial shockwave (8), such that the incidence of the shockwave (8) on the focusing pocket of fluid (4) concentrates the intensity of a shockwave subsequently incident upon the target pocket of gas (6). An apparatus for producing a localised concentration of energy is also provided.
A method of producing a localised concentration of energy comprises creating a shockwave (16) propagating through a non-gaseous medium (4) so as to be incident upon a boundary (10) between the non-gaseous medium (4) and a gaseous medium (6) formed by at least one hole (8) in a barrier (2) separating the non-gaseous medium (4) from a gaseous medium (6). This forms a transverse jet on the other side of the hole (8) which is incident upon a target surface (12) comprising a depression (14) which is spaced from the barrier (2) in the gaseous medium (6). An apparatus for producing a localised concentration of energy is also provided.
An apparatus and method for analysing breath, in particular volatile organic compounds such as acetone in breath and for calibrating breath analysis measurements using a breath- derived background sample. Breath is sampled directly through a mouth piece where flow rate and carbon dioxide are monitored, and is in part drawn through a cold trap into a spectroscopic measurement cell, such as for carrying out cavity-enhanced absorption spectroscopy, and also in part drawn through a molecular sieve trap into a holding cell or bellows of flexible volume. Measurements are then made on the sample in this spectroscopic cell and subsequently on the background sample derived from the holding cell. The cold trap is designed to reduce the water content of the breath sample to a predetermined level by reducing the temperature of the breath to a predetermined level. Knowing the quantity of water allows the absorption cross section of water also to be known, providing a direct calibration of the response of the instrument. The molecular sieve is selected to remove water and the analyte of interest, this resulting in a breath- derived background sample which includes exhaled methane and carbon dioxide and thus provides an appropriate background level for the individual subject against which the absorption measurement on the dried breath sample can be compared to quantify the analyte of interest.
The invention provides a process for producing a layer of a semiconductor material, wherein the process comprises: a) disposing on a substrate: i) a plurality of particles of a semiconductor material, ii) a binder, wherein the binder is a molecular compound comprising at least one metal atom or metalloid atom, and iii) a solvent; and b) removing the solvent. The invention also provides a layer of semiconductor material obtainable by this process. In a preferred embodiment, the particles of a semiconductor material comprise mesoporous particles of the semiconductor material or mesoporous single crystals of the semiconductor material. The invention provides a process for producing a compact layer of a semiconductor material, wherein the process comprises: disposing on a substrate i) a solvent, and ii) a molecular compound comprising at least one metal or metalloid atom and one or more groups of formula OR, wherein each R is the same or different and is an unsubstituted or substituted C1-C8 hydrocarbyl group, and wherein two or more R groups may be bonded to each other; and b) removing the solvent. The invention also provides a compact layer of a semiconductor material obtainable by this process. These processes can be effectively performed at temperatures of less than 300°C. Further provided are semiconductor devices comprising either a layer of a semiconductor material or a compact layer of a semiconductor material obtainable by the processes of the invention. The invention also provides a process for producing a semiconductor device.
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
Generating a 3D reconstruction of an environment around a monitoring-unit as that monitoring-unit is moved through the environment: a) providing at least a camera and a LIDAR sensor, each being controlled by independent clocks; b) using the camera to determine the trajectory of the monitoring-unit and determining a first time series using the clock of the camera, where the first time series details when the monitoring-unit was at predetermined points of the trajectory; c) recording the returns from the LIDAR sensor and determining a second time series using the clock of the LIDAR sensor, where the second time series details when each scan from the LIDAR was taken; d) using a timer to relate the first and second series in order to match the return from the LIDAR sensor to the point on the trajectory at which the return was received; and e) creating the 3D reconstruction based upon the LIDAR returns using information from the two time series.
A method of obtaining an image of bone using magnetic resonance imaging, the method comprising the step of selecting the scanning parameters for the magnetic resonance imaging device, wherein the scanning parameters comprise a low flip angle, a short time to repetition and a short time to echo.
G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
82.
ANALYSING VIDEO IMAGES OF A SUBJECT TO IDENTIFY SPATIAL IMAGE AREAS WHICH CONTAIN PERIODIC INTENSITY VARIATIONS
An image of a human, animal or machine subject, is analysed to detect regions which include strong periodic intensity variations, such as a photoplethysmogram (PPG) signal in a human or animal, or some periodic vibration in a machine. The image is divided into plural regions of interest and within each region an autoregressive model of fixed order is fitted to a representative intensity signal for that region. The poles of the fitted autoregressive model are thresholded by magnitude to select only the pole or poles with a magnitude greater than the threshold. The pole magnitude therefore acts as a signal quality index. The dominant pole is representative of the strongest periodic information and the frequency of that spectral component can be derived from the phase angle of the pole. The image may be redisplayed with image attributes, e.g. colour-coding, according to the pole magnitude in each region of interest and/or the dominant pole phase angle in each region of interest. In the case of a PPG image signal this can give maps of heart rate and breathing rate.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
83.
PROCESSES FOR DESALINATION AND PURIFICATION BY FORWARD OSMOSIS
The present invention provides a process for producing desalinated water, the process comprising: providing a saline solution (1); providing an aqueous draw solution (2) comprising a metal bicarbonate, wherein said metal bicarbonate is selected from calcium bicarbonate, magnesium bicarbonate and mixtures thereof; drawing water from the saline solution into the aqueous draw solution by forward osmosis across a selectively permeable membrane (3), such that the aqueous draw solution is diluted with desalinated water; and recovering desalinated water (7) from the diluted aqueous draw solution (4) by heating in a vessel (5). Precipitated metal carbonate (8) and a gaseous carbon dioxide containing stream (10) are passed to a vessel (9) containing water, to form an aqueous metal bicarbonate solution which is recycled as draw solution. The present invention also provides a process for the purification of gaseous streams containing carbon dioxide.
Delivering electrically charged liquids A liquid delivery device comprising a discharge tip (6) and an elongated channel (2) for delivering charged liquid from an apparatus to the discharge tip (6), wherein at least a portion of the elongated channel (2) has an electrically insulating sheath (8) to enable manual manipulation of the device. The elongated channel (2) may be at least partially flexible e.g. formed from flexible tubing.
A cordless liquid dispensing apparatus (100) for hand held use comprises a mount (116) for a reservoir of liquid (112), an electrically driven pump (106) arranged to deliver liquid from the reservoir (112) to a discharge tip (120) at a liquid delivery rate, and a high voltage power source (104) arranged to charge the liquid at the discharge tip (120). A microcontroller is arranged to control the pump speed (106), so as to adjust a non-zero value of the liquid delivery rate.
A method of detecting the structural elements within a scene sensed by at least one sensor within a locale, the method comprising: a) capturing data from the sensor, which data provides a first representation of the sensed scene at the current time; b) generating a second representation of the sensed scene where the second representation is generated from a prior model of the locale; and c) comparing the first and second representations with one another to determine which parts of the first representation represent structural elements of the locale.
The present invention provides a particle comprising a fusion protein, wherein the fusion protein comprises at least one NANP repeat, some or all of the C-terminus of the CS protein from Plasmodium falciparum and a hepatitis B surface antigen, and wherein the particle comprises no, or substantially no, free hepatitis B surface antigen protein, and uses thereof.
An image processing method performed by a processor and comprising: receiving a first image containing one or more objects of interest; deriving local phase and local orientation information from the first image; identifying one or more edge features of the object(s) of interest using the local phase information; and fitting one or more parametric shapes to the edge feature(s) of the object(s) of interest using the local orientation information.
The invention relates to a method for delivering a molecule to a reproductive cell or an embryonic cell. The invention uses mesoporous silica nanoparticles.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
According to the present invention, there is provided a method of detecting a membrane protein by mass spectrometry, the method comprising the steps of: (a) providing a solution comprising a detergent micelle in which said membrane protein is contained, wherein said solution contains a polyoxyalkylene glycol detergent; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the membrane protein is released from the micelle; (d) ionising the membrane protein; (e) resolving the ionised membrane protein using the mass analyser; and (f) detecting the resolved membrane protein using the detector. Also provided are reagents for use in said method.
An apparatus comprises a charged particle beam source and a target (1) for a charged particle beam. The target comprises a concave outer surface which is at least a segment of a cylinder (2) having a periodically structured surface (4). The charged particle beam is directed parallel to the axis of the cylinder (2), with the distance of the charged particle beam from the surface being less than or equal to twice the period of the periodically structured surface (4) in a direction perpendicular to the charged particle beam. The width of the charged particle beam in a direction perpendicular to the charged particle beam and parallel to the outer surface of the target is less than twice the period of the periodically structured surface (4) in a direction perpendicular to the charged particle beam.
H01J 37/04 - Arrangements of electrodes and associated parts for generating or controlling the discharge, e.g. electron-optical arrangement, ion-optical arrangement
The present invention relates to immunogenic compositions for use in aerosol delivery to the respiratory tract of a human. The compositions comprise an expression vector, which comprise one or more exogenous nucleotide sequences from one or more pathogens. The compositions are able to elicit a protective immune response and, in particular, elicit both a local mucosal and systemic immune response, which is protective.
The present invention relates to transgenic plants and in particular to transgenic plants having one or more modified genes resulting in phenotypic changes in leaf anatomy and/or vein spacing within the plant, from the C3 photosynthetic pathway to C4. The invention also relates to the genes which give rise to said phenotypic changes.
The present invention relates to a sensor (104) for measuring temperature of a fluid within a vessel (106), the vessel (106) having a first region and a second region and the fluid having a temperature profile extending between the first region and the second region, the sensor (104) comprising an array of elements (300), each element (300) having a temperature-dependent parameter, the array being capable of deployment within or adjacent the vessel (106) such that the array extends along the vessel (106) for measuring the temperature profile, the elements (300) of the array being coupled together between an input and an output, the input being coupled or capable of being coupled to a driving source for driving the sensors (104), and the output being coupled or capable of being coupled to a detector for measuring an aggregate of the temperature-dependent parameter from the array of elements (300). The invention further relates to a fluid temperature controller (100) comprising a first input for receiving a first signal (102) indicating a measurement of an aggregate of a temperature-dependent parameter from a sensor according to any preceding claim deployed within or adjacent a vessel containing a fluid having a temperature profile, a second input (108) for receiving a second signal indicating a (preferably absolute) temperature of the fluid in the vessel (106) and a processor (110) configured to calculate a total thermal energy of the fluid in the vessel (106) based on the first and second signals. The invention also relates to a combination comprising a sensing arrangement and a controller; a device; and a system.
The invention relates to an apparatus for producing a droplet assembly, which apparatus comprises a droplet generator. A process for producing a droplet assembly, using an apparatus comprising a droplet generator is also described. The invention also relates to droplet assemblies comprising a plurality of droplets. Various uses of the droplet assemblies are also described.
This invention relates to fluorinating agents and, more particularly, to chiral non-racemic fluorinating agents useful for enantioselective fluorination, as well as to their synthesis and use and other subject matter. The fluorinating agents are based on a substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) skeleton and provide electrophillic fluorine enantioselectively.
C07D 215/58 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
The invention relates to a process for moving a droplet from a first location to a second location, which droplet comprises a magnetic material disposed in an aqueous medium. The invention also relates to a droplet assembly comprising a droplet, which droplet comprises a magnetic material disposed in an aqueous medium. Various uses of the droplet assembly are also described.
An imaging system for an object such as human or animal tissue applies acoustic vibrations localized in two or three dimensions and simultaneously illuminates the object with an illuminating electromagnetic wave. A transmitter or receiver is provided that has an antenna with at least one coil that surrounds an axis along which at least a portion of the acoustic vibration is output.
G01N 22/00 - Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
The invention provides a hydrogel network comprising a plurality of hydrogel objects, wherein each of said hydrogel objects comprises: a hydrogel body, and an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body, wherein each of said hydrogel objects contacts another of said hydrogel objects to form an interface between the contacting hydrogel objects. A process for producing the hydrogel networks is also provided. The invention also provides an electrochemical circuit and a hydrogel component for mechanical devices comprising a hydrogel network. Various uses of the hydrogel network are also described, including their use in synthetic biology and as components in electrochemical circuits and mechanical devices.
H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
The present invention provides a bifunctional catalyst of the formula (1): wherein: each R1 is independently selected from an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted aralkyl group and an optionally substituted alkaryl group; Z represents a divalent organic linking moiety optionally containing one or more stereocentres; and EWG represents an electron-withdrawing group.
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