The present invention relates to the treatment of PRAME-expressing cancers, in particular by administration of a plurality of PRAME-based synthetic long peptides or nucleic acids encoding such SLPs. Furthermore, the invention relates to immunogenic compositions suitable for use in the method of treatment of the invention. Moreover, the invention relates to methods for selecting antigens suitable for use in immunization by determining their ability to increase CCR7 and/or CD40 levels in antigen-presenting cells.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
The present disclosure relates to methods of treating or inhibiting head and neck cancer comprising administering a combination of a PD-1 inhibitor and one or more immunogenic compositions capable of inducing an immune response against cells expressing HPV16 antigens. Furthermore, the disclosure relates to treatment of a subject afflicted with a solid tumor, comprising administering one or more immunogenic compositions comprising one or more tumor antigens to said subject, wherein a tumor sample of said subject exhibits a high level of PD-1 expression.
The disclosed invention is in the field of analytical chemistry. In particular, it relates to methods for improved quantification of analytes in complex mixtures, and to compositions comprising precise amounts of said analytes. The improved method uses stable reference standards.
The present invention relates to the field of immunology. In particular, it relates to novel long cysteine-containing immunogenic peptides, wherein the cysteine has been modified to yield a more stable product while preserving immunogenicity. The invention further relates to compositions and methods for treating diseases using the long immunogenic peptides of the invention.
The invention relates to an immunogenic peptide for use in combination with a Toll-like receptor 2 agonist in the immunization of a human subject, wherein said Toll-like receptor 2 agonist is a lipopeptide which is not covalently linked to said immunogenic peptide and wherein said immunogenic peptide and said Toll-like receptor 2 agonist are administered intradermally at the same site.
The disclosed invention is in the field of analytical chemistry. In particular, it relates to methods for improved quantification of analytes in complex mixtures, and to compositions comprising precise amounts of said analytes. The improved method uses stable reference standards.
The invention provides long immunogenic peptides for treating diseases related to severe acute respiratory syndrome coronaviruses, such as SARS-CoV-2 or SARS-CoV-1. The invention also provides immunogenic compositions and vaccines comprises long immunogenic peptides of the invention and method of therapeutic treatment or prevention of SARS-CoV-related diseases comprising administration of immunogenic peptides according to the invention.
The invention provides methods for treating infections, disorders or diseases caused by a human papillomavirus other than HPV-16 by determining the HPV type of the patient, providing a synthetic-long-peptide based therapeutic vaccine for treatment of said patient and administering said therapeutic vaccine to said patient. The invention further provides novel immunogenic compositions and therapeutic vaccines against human papillomaviruses other than HPV-16 and uses thereof.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
9.
IMPROVED SUBSTANCE QUANTIFICATION IN COMPLEX MIXTURES
The disclosed invention is in the field of analytical chemistry. In particular, it relates to methods for improved quantification of analytes in complex mixtures, and to compositions comprising precise amounts of said analytes. The improved method uses stable reference standards.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/84 - Systems specially adapted for particular applications
10.
IMPROVED SUBSTANCE QUANTIFICATION IN COMPLEX MIXTURES
The disclosed invention is in the field of analytical chemistry. In particular, it relates to methods for improved quantification of analytes in complex mixtures, and to compositions comprising precise amounts of said analytes. The improved method uses stable reference standards.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/84 - Systems specially adapted for particular applications
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical and medicinal preparations for the treatment of viral infections, cancer and pre-cancerous disorders; active pharmaceutical substances based on synthetic long peptides which may be modified to improve the immune response and may be combined with other pharmaceutical products for the treatment of viral infections, cancer and pre-cancerous disorders; immune response adjuvants for medical purposes; pharmaceutical compounds for treating viral infections, cancer and pre-cancerous disorders by means of immune system modulation
The invention provides long immunogenic peptides for treating diseases related to severe acute respiratory syndrome coronaviruses, such as SARS-CoV-2 or SARS-CoV-1. The invention also provides immunogenic compositions and vaccines comprises long immunogenic peptides of the invention and method of therapeutic treatment or prevention of SARS-CoV-related diseases comprising administration of immunogenic peptides according to the invention.
ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (Netherlands)
ISA PHARMACEUTICALS B.V. (Netherlands)
Inventor
Buschow, Sonja Ingrid
De Beijer, Monica Theodora Antonetta
Molenaar, Miranda Bernardina Johanna
Beenakker, Thomas Johannes Maria
Krebber, Wilhelmus Johannes Theodorus Alexander
Melief, Cornelis Johannes Maria
Wiekmeijer, Anna-Sophia
Van Rijn, Peter
Jansen, Diahann Talia Satirah Ludovica
Van Esch, Wilhelmus Johannes Elisabeth
Abstract
The invention provides novel immunogenic peptides derived from the X protein and polymerase protein of hepatitis B virus (HBV). The peptides contain epitopes that are well-conserved across multiple HBV variants and are derived from regions of proteins that are essential for viral replication. Moreover, the novel HBV antigens bind multiple HLA types and epitopes that elicit IFN? responses in PBMCs from HBV resolvers have been identified.
The invention relates to a novel reconstitution composition, a pharmaceutical composition and kit of parts comprising said reconstitution composition. The invention further relates to a method of treatment using said pharmaceutical composition and/or the pharmaceutical composition for use as a medicament. Also provided is a method for reconstituting dried peptides and a method for preparing a pharmaceutical composition using the reconstitution composition of the invention.
The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.
The present invention relates to the fields of medicine and immunology. In particular, it relates to novel peptides that may be used in the treatment and/or prevention of a Hepatitis B viral infection and/or an Hepatitis B related disease or condition.
The invention relates to a novel reconstitution composition, a pharmaceutical composition and kit of parts comprising said reconstitution composition. The invention further relates to a method of treatment using said pharmaceutical composition and/or the pharmaceutical composition for use as a medicament. Also provided is a method for reconstituting dried peptides and a method for preparing a pharmaceutical composition using the reconstitution composition of the invention.
A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
Krebber, Wilhelmus, Johannes, Theodorus, Alexander
Hermans, Ian, Francis
Zon, Gijsbertus, Gerardus, Petrus
Abstract
The invention relates to a method of immunizing a human subject comprising combined administration of: an antigen, an iNKT cell agonist, and a Toll-like receptor 2 agonist. The invention further relates to compositions and kits for use in the method of the invention.
The invention relates to a novel reconstitution composition, a pharmaceutical composition and kit of parts comprising said reconstitution composition. The invention further relates to a method of treatment using said pharmaceutical composition and/or the pharmaceutical composition for use as a medicament. Also provided is a method for reconstituting dried peptides and a method for preparing a pharmaceutical composition using the reconstitution composition of the invention.
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
The invention relates to a novel reconstitution composition, a pharmaceutical composition and kit of parts comprising said reconstitution composition. The invention further relates to a method of treatment using said pharmaceutical composition and/or the pharmaceutical composition for use as a medicament. Also provided is a method for reconstituting dried peptides and a method for preparing a pharmaceutical composition using the reconstitution composition of the invention.
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.
The present invention relates to the fields of medicine and immunology. In particular, it relates to novel peptides that may be used in the treatment and/or prevention of a Hepatitis B viral infection and/or an Hepatitis B related disease or condition.
The invention is directed to a compound according to the formula [1]
2 are branched or straight groups having up to 17 atoms selected from carbon, nitrogen, oxygen and sulphur, n is 0 to and including 18, Y is sulphur or selene, X is S or O and R is —OH or an organic group comprising one or more peptides, one or more nucleic acids, one or more antibodies or combinations thereof. The invention is also directed to process for preparing said compound and the use of said compound as an adjuvant. The invention is also directed to a composition comprising said compound and the use of said composition, for example as a vaccine composition.
A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
C07K 7/04 - Linear peptides containing only normal peptide links
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
A61K 39/00 - Medicinal preparations containing antigens or antibodies
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Customized pharmaceutical and medicinal preparations, namely, tumor neo-antigen derived immunotherapeutic formulations for the treatment of an individual patient Scientific and technological services, namely, research and design relating thereto in the biotechnological, chemical and pharmaceutical field and in the field of immunotherapy; industrial analysis, namely, analysis of the design, manufacturing and development of immunotherapy pharmaceuticals; research services in the field of pharmaceuticals; scientific research and development services in the biotechnological, chemical and pharmaceutical field and in the field of immunotherapy Medical services in the biotechnological and pharmaceutical field and in the field of immunotherapy; medical counseling in the field of customized pharmaceutical and medicinal preparations; medical analyses services in the field of customized pharmaceutical and medicinal preparations; medical screening; dispensing of pharmaceutical and medicinal preparations; none of the foregoing services being provided for or in relation to the treatment of snoring or sleep disorders
25.
SYNTHETIC LONG PEPTIDES (SLP) FOR THERAPEUTIC VACCINATION AGAINST HEPATITIS B VIRUS INFECTION
The present invention relates to the fields of medicine and immunology. In particular, it relates to novel peptides that may be used in the treatment and/or prevention of a Hepatitis B viral infection and/or an Hepatitis B related disease or condition.
A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
26.
SYNTHETIC LONG PEPTIDES (SLP) FOR THERAPEUTIC VACCINATION AGAINST HEPATITIS B VIRUS INFECTION
The present invention relates to the fields of medicine and immunology. In particular, it relates to novel peptides that may be used in the treatment and/or prevention of a Hepatitis B viral infection and/or an Hepatitis B related disease or condition.
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and medicinal preparations; customized pharmaceutical and medicinal preparations. Scientific and technological services and research and design relating thereto in the biotechnological, chemical and pharmaceutical field and in the field of immunotherapy; industrial analysis and research services; scientific research and development services in the biotechnological, chemical and pharmaceutical field and in the field of immunotherapy. Medical services in the biotechnological and pharmaceutical field and in the field of immunotherapy; medical counselling in the field of customized pharmaceutical and medicinal preparations; medical analyses services in the field of customized pharmaceutical and medicinal preparations; medical screening; preparation and dispensing of pharmaceutical and medicinal; none of the foregoing services being provided for or in relation to the treatment of snoring or sleep disorders.
2 are branched or straight groups having up to 17 atoms selected from carbon, nitrogen, oxygen and sulphur, n is 0 to and including 18, Y is sulphur or selene, X is S or 0 and R is —OH or an organic group comprising one or more peptides, one or more nucleic acids, one or more antibodies or combinations thereof. The invention is also directed to process for preparing said compound and the use of said compound as an adjuvant. The invention is also directed to a composition comprising said compound and the use of said composition, for example as a vaccine composition.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
C07K 7/04 - Linear peptides containing only normal peptide links
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
A61K 39/00 - Medicinal preparations containing antigens or antibodies
29.
HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines
The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
[ Pharmaceutical and medicinal preparations for the treatment of viral infections, cancer and pre-cancerous disorders; active pharmaceutical substances based on synthetic long peptides which may be modified to improve the immune response and may be combined with other pharmaceutical products for the treatment of viral infections, cancer and pre-cancerous disorders; immune response adjuvants for medical purposes; pharmaceutical compounds for treating viral infections, cancer and pre-cancerous disorders by means of immune system modulation ] Scientific and technological services and research and design relating thereto in the biotechnological, chemical and pharmaceutical field and in the field of immunotherapy; industrial analysis, namely, analysis of the design, manufacturing and development of immunotherapy pharmaceuticals; research services in the field of pharmaceuticals; scientific research and development services in the biotechnological, chemical and pharmaceutical field and in the field of immunotherapy Medical services in the biotechnological and pharmaceutical field and in the field of immunotherapy
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and medicinal preparations; active pharmaceutical substances based on synthetic long peptides which may be modified to improve the immune response and may be combined with other pharmaceutical products; immune response adjuvants; compounds for treating diseases by means of immune system modulation. Scientific and technological services and research and design relating thereto in the biotechnological, chemical and pharmaceutical field and in the field of immunotherapy; industrial analysis and research services; scientific research and development services in the biotechnological, chemical and pharmaceutical field and in the field of immunotherapy. Medical services in the biotechnological and pharmaceutical field and in the field of immunotherapy.
32.
PAM3CYS-LIKE LIPOPEPTIDE ADJUVANT COMPOUND IN A VACCINE COMPOSITION
The invention is directed to a compound according to the formula [1] wherein R1 and R2 are branched or straight groups having up to 17 atoms selected from carbon, nitrogen, oxygen and sulphur, n is 0 to and including 18, Y is sulphur or selene, X is S or 0 and R is -OH or an organic group comprising one or more peptides, one or more nucleic acids, one or more antibodies or combinations thereof. The invention is also directed to process for preparing said compound and the use of said compound as an adjuvant. The invention is also directed to a composition comprising said compound and the use of said composition, for example as a vaccine composition.
The invention is directed to a compound according to the formula [1] wherein R1 and R2 are branched or straight groups having up to 17 atoms selected from carbon, nitrogen, oxygen and sulphur, n is 0 to and including 18, Y is sulphur or selene, X is S or 0 and R is -OH or an organic group comprising one or more peptides, one or more nucleic acids, one or more antibodies or combinations thereof. The invention is also directed to process for preparing said compound and the use of said compound as an adjuvant. The invention is also directed to a composition comprising said compound and the use of said composition, for example as a vaccine composition.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Ingredients for pharmaceutical compositions, namely toll like receptor agonist adjuvants to enhance an immune cell mediated immune system response, marketed solely to manufactures of immune therapeutics, including vaccines and antibodies.
35.
PEPTIDES INDUCING OR ENHANCING AN IMMUNE RESPONSE AGAINST PROSTATE-SPECIFIC MEMBRANE PROTEIN (PSMA)
The present invention relates to the fields of medicine and immunology. In particular, it relates to novel peptides that may be used in the treatment, prevention and/or delay of a PSMA related disease or condition.
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Medical services pertaining to the field of cancer and infectious diseases therapies; Veterinary assistance; hygienic care for human beings pertaining to the field of cancer and infectious diseases therapies, hygienic care for animals; agriculture, horticulture and forestry services.
