The present invention provides a process for chiral resolution of trans-2,2-dichloro-3-(3,5- dichlorophenyl)-cyclopropane-1-carboxylic acid by chiral chromatography using an eluent comprising a mixture of an apolar solvent and a polar co-solvent selected from aliphatic alcohols, ethyl acetate and acetonitrile, and using a chiral stationary phase selected from the list consisting of amylose tris (S)-α-methylbenzyl carbamate, amylose tris (3-chloro-4-methylphenylcarbamate), amylose tris (3,5-dimethylphenylcarbamate) and amylose tris (3-chloro-5-methylphenylcarbamate).
C07C 51/47 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
4.
PROCESS FOR CHIRAL RESOLUTION OF TRANS-2,2-DICHLORO-3-(3-CHLORO-4-FLUOROPHENYL)-CYCLOPROPANE-1-CARBOXYLIC ACID BY CHIRAL CHROMATOGRAPHY
The present invention provides a process for chiral resolution of trans-2,2-dichloro-3-(3-chloro-4- fluorophenyl)cyclopropane-1-carboxylic acid by chiral chromatography using an eluent comprising a mixture of an apolar solvent and a polar co-solvent selected from aliphatic alcohols, ethyl acetate and acetonitrile, and a chiral stationary phase selected from the list consisting of amylose tris(3,5- dimethylphenylcarbamate) and cellulose tris (4-methylbenzoate).
C07C 51/47 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
5.
A VACCINE FOR PROTECTING A PREGNANT SWINE AGAINST AFRICAN SWINE
The present invention pertains to the use of a live attenuated African swine fever virus Georgia 2007-Δ9GL/ΔUK/ΔEP153R (ASFV-G-Δ9GL/ΔUK/ΔEP153R) strain for protecting a pregnant swine against an infection with African swine fever virus (ASFV) by administering a vaccine comprising the live attenuated ASFV-G-Δ9GL/ΔUK/ΔEP153R strain to the pregnant swine.
The invention pertains to a live attenuated African swine fever virus Georgia 2007 (ASFV-G) Δ9GL/ΔUK/ΔEP153R strain for use in a vaccine for protecting a swine against an infection with African swine fever virus (ASFV) by administering the vaccine comprising the live attenuated ASFV-G-Δ9GL/ΔUK/ΔEP153R strain to the swine.
P. multocidaP. multocidaP. multocidaP. multocida, methods of improving the respiratory function of a ruminant, methods of treating, ameliorating and/or preventing a diseased state in a ruminant and to a kit-of-parts at least comprising a container comprising the vaccine of the invention.
The present invention relates to a process for purification of intermediates of prostaglandin F2α compounds and its conversion to therapeutically active prostaglandin F2α compounds, for example, racemic cloprostenol. Particularly relates to a process for purification of intermediates of racemic cloprostenol by solvent crystallization and/or derivatization of hydroxyl compounds and recycling process of the unwanted isomers to make the process commercially viable. Further, the present invention relates to an improved process for preparation of prostaglandin F2α compounds and its sodium salt.
C07D 307/935 - Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
C07C 405/00 - Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
Electronic animal identification apparatus; radio-frequency
identification (RFID) readers; radio-frequency
identification (RFID) tags; microchips; temperature sensors;
RFID tags worn by pets that activate pet care devices;
electronic devices for detecting and locating pets using
radio frequency; transmitters and receivers used to locate
lost pets. Providing temporary use of non-downloadable cloud-based
software for monitoring and identifying companion animals;
providing temporary use of non-downloadable cloud-based
software for assisting in reporting, identifying, and
locating lost pets; providing temporary use of
non-downloadable cloud-based software for facilitating
communications between pet owners and veterinary
professionals. Surgical implantation of microchips into pets; implanting
subcutaneous microchips by injection into pets; providing
information and advice in the field of pet health; providing
veterinary information; veterinary information services
provided via the Internet. Providing an on-line searchable database featuring
information on lost and found pets; assisting in the
locating of lost pets; providing information in the field of
lost pets.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Vaccines for animal use.
13.
A FREEZE-DRIED COMPOSITION CONTAINING LIVE ATTENUATED PATHOGENS, A PROCESS FOR PREPARING A FREEZE-DRIED COMPOSITION, A VACCINE, AND A METHOD OF VACCINATING A HOST ANIMAL
In order to provide a composition which has retained a relatively high antigenic activity during freeze-drying, a freeze-dried composition is provided comprising live attenuated pathogens, and a bulking agent that comprises in combination (i) polyvinylpyrrolidone with a weight-averaged molecular weight between 1000 and 7000 Da in an amount of at least 1 wt/vol%, based on the composition before freeze drying, and (ii) a sugar.
C07C 259/06 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
C07B 59/00 - Introduction of isotopes of elements into organic compounds
A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
A61P 11/00 - Drugs for disorders of the respiratory system
C07C 213/08 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
C07C 217/08 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
C07C 259/06 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
This invention is directed to a veterinary pour-on formulation comprising a UV absorbing molecule that is used to stabilize the colour of the formulation and reduce the degradation of the active pharmaceutical ingredient.
A01N 53/00 - Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
A01N 25/22 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
The present invention relates to the field of veterinary vaccines. More specifically, the invention relates to a composition and to vaccines comprising Mollicutes bacteria inactivated by low- energy electron irradiation (LEEI), to methods for producing said composition or said vaccines, and to use of said composition, and of said vaccines for the protection of swine against infection or disease caused by Mollicutes bacteria.
A method of preparing 4-fluoro-3-methoxyaniline comprising reducing 1-bromo-5-fluoro-4-methoxy-2-nitrobenzene with a catalyst that produces increased yields.
C07C 68/02 - Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
C07C 201/08 - Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
C07C 201/14 - Preparation of nitro compounds by formation of nitro groups together with reactions not involving the formation of nitro groups
C07C 213/02 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
transtranstrans)-2,2- dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-1-carboxylic acid with a chiral base selected from the list consisting of quinine, (R)-1-cyclohexylethan-1-amine, (S)-1-cyclohexylethan-1-amine and (L)-leucinamide in an organic solvent to form a suspension, (b) isolating a diastereoisomeric salt of the desired enantiomer and the chiral base from the suspension, and (c) optionally, treating the isolated diastereoisomeric salt with an acid to obtain the desired enantiomer of 2,2-dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-1- carboxylic acid.
C07C 51/487 - SeparationPurificationStabilisationUse of additives by treatment giving rise to chemical modification
C07C 211/17 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings containing only non-condensed rings
The invention relates to recombinant insulin precursors. To improve the recombinant production of insulin, a recombinant insulin precursor according to the formula L-B-C-A is provided, wherein A is an A-chain of insulin, B is a B-chain of insulin, C is a C-peptide connecting the A- chain and the B-chain, and L is an N-terminal L-peptide. The C-peptide comprises an amino acid sequence according to SEQ ID NO: 1 and/or the L-peptide comprises an amino acid sequence according to SEQ ID NO: 2.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
(1) Electronic animal identification apparatus; radio-frequency identification (RFID) readers; radio-frequency identification (RFID) tags; microchips; temperature sensors; RFID tags worn by pets that activate pet care devices; electronic devices for detecting and locating pets using radio frequency; transmitters and receivers used to locate lost pets. (1) Providing temporary use of non-downloadable cloud-based software for monitoring and identifying companion animals; providing temporary use of non-downloadable cloud-based software for assisting in reporting, identifying, and locating lost pets; providing temporary use of non-downloadable cloud-based software for facilitating communications between pet owners and veterinary professionals.
(2) Surgical implantation of microchips into pets; implanting subcutaneous microchips by injection into pets; providing information and advice in the field of pet health; providing veterinary information; veterinary information services provided via the Internet.
(3) Providing an on-line searchable database featuring information on lost and found pets; assisting in the locating of lost pets; providing information in the field of lost pets.
26.
A PROCESS FOR PREPARING 2-AMINO-3,5-DIFLUOROPYRIDINE OR A SALT THEREOF
The present invention provides a process for preparing 2-amino-3,5-difluoropyridine (compound F) or a salt thereof from 2,3,5-trichloropyridine (compound A) involving 3,5-difluoro-2-pyridinecarbonitrile (compound D) and 3,5-difluoro-2-pyridinecarboxamide (compound E). The process is characterized by a high purity and yield and is suitable to be used in large scale production.
The present invention provides a process for preparing 3,5-difluoro-2-pyridinecarboxamide (compound E), which comprises a step of subjecting 3,5-difluoro-2-pyridinecarbonitrile (compound D) to hydrolysis. The resulting compound D can be used as an intermediate in preparation of 2-amino-3,5-difluoropyridine. The process is characterized by a high purity and yield and is suitable to be used in large scale production.
The present invention provides a process for preparing 2-amino-3,5-difluoropyridine (compound F) or a salt thereof from 3,5-difluoro-2-pyridinecarboxamide (compound E) comprising the step of subjecting compound E to Hofmann rearrangement to obtain compound F. The process is characterized by a high purity and yield and is suitable to be used in large scale production.
The invention relates to an animal identification and/or monitoring device applicator (1) comprising two jaws (13, 14) intended to receive an animal ear to be tagged comprising a female and a male component (31, 32), said male component comprising a tip and said female component comprising a through-hole (321) for receiving the tip. The applicator comprises mechanism for securing an element to one of said jaws, said securing mechanism comprising elastic return means (42, 52) and a mobile retaining part (41, 51) for holding the female before assembly, said second jaw having an internal space (141) in which the securing mechanism is mounted, and said retaining part being movably between: • - a securing position in which the retaining part secures the female component on said second jaw, and • - a release position in which the retaining part is pressed so as to release the female component from said second jaw.
The invention provides a recombinant pyolysin protein. Preferably a recombinant pyolysin protein is provided comprising at least 80% sequence identity to SEQ ID NO: 1, wherein the amino acid sequence comprises (i) an amino acid deletion at amino acid position 472, and/or (ii) an amino acid substitution at amino acid position 496 and/or at 497. Also provided by the invention are nucleic acid sequences encoding the recombinant pyolysin protein, and methods for producing of the same. The invention lastly provides for methods of amelioration and/or prevention of intrauterine disease, liver abscess and/or foot rot or vaccine compositions for use in prophylaxis of the same.
The invention pertains to a live attenuated African swine fever virus Georgia 2007 (ASFV-G) Δ9GL/ΔUK strain for use in a vaccine for protecting a piglet against an infection with African swine fever virus (ASFV) by administering the vaccine comprising the live attenuated ASFV-G-Δ9GL/ΔUK strain to a pregnant swine the piglet being part of the progeny of the pregnant swine.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Veterinary preparations and substances. Computer software in connection with animal health and wellbeing; downloadable mobile application in connection with animal health and wellbeing; apparatus for monitoring behavior and activity in animals. Veterinary apparatus and instruments. Education and training in the fields of animal health and wellbeing, veterinary products and services. Scientific and technological services and research and design relating thereto in the fields of animal health and wellbeing, veterinary products and services; providing a web-based system and online portal featuring on-line non downloadable software in connection with animal health and wellbeing, veterinary products and services. Providing information and advice relating to animal health and wellbeing, veterinary products and services.
The current invention provides the use compounds of Formula (I) which are JAK inhibitors, and as such for the treatment of JAK-1 mediated diseases such as atopic—and allergic dermatitis in young animals.
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
transtranstrans)-2,2- dichloro-3-(3,5-dichlorophenyl)cyclopropane-1-carboxylic acid with a chiral base being either (1S,2R)-2- amino-1,2-diphenylethan-1-ol or (1R,2S)-2-amino-1,2-diphenylethan-1-ol in an organic solvent to form a suspension, (b) isolating a diastereoisomeric salt of the desired enantiomer and the chiral base from the suspension, and (c) optionally, treating the isolated diastereoisomeric salt with an acid to obtain the desired enantiomer of 2,2-dichloro-3-(3,5-dichlorophenyl)cyclopropane-1-carboxylic acid.
C07C 215/30 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Equipment and devices used in science, navigation, surveying, photography, cinematography and -exhibition; optical, weighing, measuring devices, signaling devices, supervisory, rescue, teaching aids and equipment; equipment and instruments for conducting, switching on and off, transforming, accumulating, regulating or controlling electricity; tools used to record, transfer or reproduction of sound or images; magnetic data carriers, recording discs; CD-ROMs, DVDs and other digital recording media; data processing equipment and computers; computer software; measuring, detecting, monitoring and controlling and software for sorting, counting, pumping, scanning, feeding and handling organisms especially freshwater and marine species in freshwater or sea, including use in aquaculture; measuring, detecting, monitoring and controlling equipment and software to monitor and examine the condition of organisms, especially aquatic and marine organisms in freshwater or sea, as well as factors such as temperature and chemical composition; measuring, detecting, monitoring and controlling equipment and software to manage aquaculture systems. Scientific and technological services and research and design relating thereto; analysis and research services in the field of industry; design and development of computer hardware and software, biological tests, calibration and measurement, computer rental, rental of computer equipment, installation of computer software, maintenance of computer software, upgrading of computer software, software development, computer systems design, consultancy in the field of computers, consulting services in the field of environmental protection, industrial designs, engineering, research in the field of environmental protection, underwater exploration, installation of software, quality control, rental of software, research in biology, research in the field of environmental protection, software updates, software design, technology research, underwater exploration.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Equipment and devices used in science, navigation, surveying, photography, cinematography and exhibition; optical, weighing, measuring devices, signaling device, supervisory, rescue, teaching aids and equipment; equipment and instruments for conducting, switching on and off, transforming, accumulating, regulating or controlling electricity; tools used to record, transfer or reproduction of sound or images; magnetic data carriers, recording discs; ROMs, DVDs and other digital recovering; data processing equipment and computers; computer software; equipment and software for sorting, counting, pumping, scanning, feeding and handling organisms especially freshwater and marine species in freshwater or sea, including use in aquaculture; equipment and software to monitor and examine the condition of organisms, especially aquatic and marine freshwater or sea, as well as factors such as temperature and chemical composition, equipment and software to manage aquaculture systems (1) Scientific and technological services and research and design relating thereto; analysis and research services in the field of industry; design and development of computer hardware and software, biological tests, calibration and measurement, computer rental, rental of computer equipment, installation of computer software, maintenance of computer software, upgrading of computer software, software development, computer systems design, consultancy in the field of computers, consulting services in the field of environmental protection, the design of computer systems, industrial designs, engineering, research in the field of environmental protection, underwater exploration, installation of software, maintenance of computer software, quality control, rental of computers, rental of software, research in biology, research, environmental protection, rental of software, software updates, software design, technology research, underwater exploration
39.
CARBOXAMIDE-4-QUINOLINE COMPOUNDS WITH ANTHELMINTIC ACTIVITY
The present invention provides novel carboxamide-4-quinoline compounds that can be used as medicaments, particularly in the treatment and prevention of diseases in animals caused by helminths.
The invention relates to the field of Aqua culture, especially to the farming of Tilapia, and more specifically the invention relates to a new type of bacterium of Streptococcus agalactiae serotype Ia (Sa Ia), which is much more pathogenic than Sa Ia isolates known so far, and can break through the protection provided by existing Sa Ia vaccines. In particular the invention relates to an Sa Ia bacterium of the new breakthrough type, as defined by a number of unique features, and as deposited at the CNCM in Paris. Further the invention regards preparations, compositions, and vaccines of the new Sa Ia bacterium, regards a diagnostic kit, and regards (medical) uses, and methods for the manufacture of the preparations, compositions, and vaccines of the new Sa Ia bacterium.
The present disclosure provides exemplary codon optimized nucleic acid sequences encoding Piscine Myocarditis Virus (PMCV). Expression vectors comprising one or more of the described codon optimized nucleic acids sequences are also provided.
The present disclosure provides exemplary sequences and compositions that can be used to active immunization of animals to aid in the prevention of cardiomyopathy syndrome (CMS) caused by Piscine Myocarditis Virus (PMCV). Vaccines and kits comprising the sequences and compositions are also provided, as well as methods of administering the vaccine to non-human animals.
An injection system for treatment of the human or animal body, comprising an injector (10) having at least one chamber (18) for accommodating a treatment fluid, the chamber (18) opening out into a nozzle (20) and being connected to a pressurizing system for pressurizing the fluid in the chamber such that a skinpenetrating jet (24) is ejected from the nozzle (20), wherein the system comprises at least one alternative administering device (26, 28) for administering the treatment fluid, and the nozzle (20) of the injector is integrated with an adapter (30) that is connectable to a mating adapter (32) of said at least one alternative administering device (26. 28).
The invention pertains to a method of culturing Lawsonia intracellularis bacteria, the method comprising a) infecting a first portion of McCoy cells with Lawsonia intracellularis bacteria, b) growing the first portion of infected McCoy cells in a first growth medium at a dissolved oxygen concentration less than 18% to arrive at a first culture of McCoy cells infected with Lawsonia intracellularis bacteria, c) determining the concentration of pyroptotic McCoy cells in the first culture of McCoy cells, d) combining a second portion of the first culture of McCoy cells with a second growth medium, and passing a third portion of the first culture to a third growth medium containing fresh McCoy cells, such that the third growth medium is inoculated with 0.01-0.25 pyroptotic McCoy cells per fresh McCoy cell, e) growing the McCoy cells in the second growth medium at a dissolved oxygen concentration less than 18% and growing the McCoy cells in the third growth medium at a dissolved oxygen concentration less than 18% to arrive respectively at a second culture of McCoy cells infected with Lawsonia intracellularis bacteria and a third culture of McCoy cells infected with Lawsonia intracellularis bacteria, f) harvesting the McCoy cells infected with Lawsonia intracellularis bacteria from the second culture of McCoy cells and determining the concentration of pyroptotic McCoy cells in the third culture, and g) performing steps d)-f) for the third culture, wherein the third culture serves as the first culture of McCoy cells.
Erysipelothrix rhusiopathiaeErysipelothrix rhusiopathiaeErysipelothrix rhusiopathiae and an infection with porcine parvo virus, by injection of the first vaccine into the dermis of the pig.
The invention pertains to a vaccine comprising a non-replicating Leptospira immunogen, for use in prophylactically treating a pig against an infection with a Leptospira bacterium, by injection of the first vaccine into the dermis of the pig.
Erysipelothrix rhusiopathiaeErysipelothrix rhusiopathiaeErysipelothrix rhusiopathiae, an infection with porcine parvo virus and an infection with Leptospira bacterium, by associated separate injection of the first vaccine and the second vaccine into the dermis of the pig at a first and a second injection site of that pig respectively.
The invention pertains to a live attenuated African swine fever virus Georgia 2007 (ASFV-G) Δ9GL/ΔUK strain for use in a vaccine for protecting a pregnant swine against an infection with African swine fever virus (ASFV) by administering the vaccine comprising the live attenuated ASFV-G-Δ9GL/ΔUK strain to the pregnant swine.
Salmonid alphavirus (SAV) is an important pathogen affecting the aquaculture of Salmonid fish. Vaccines based on DNA plasmids expressing a SAV antigen have been described. However these are difficult to prepare at large scale and at the desired quality level. Also, they are commonly administered at relatively high amounts of plasmid per animal dose. This makes such DNA vaccines less affordable for this market. The invention discloses an improved plasmid that allows effective use as a DNA vaccine against SAV, but at a much reduced amount of DNA per dose. The plasmid contains a gene encoding a bacterial enzyme: Fab.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
A61K 39/00 - Medicinal preparations containing antigens or antibodies
C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
05 - Pharmaceutical, veterinary and sanitary products
06 - Common metals and ores; objects made of metal
09 - Scientific and electric apparatus and instruments
20 - Furniture and decorative products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Veterinary preparations
(2) Downloadable computer software, computer hardware, encoders, scanners, integrated circuits, radio frequency identification tag readers, readers, prerecorded magnetic data carriers all for collecting, analyzing, monitoring, managing, sharing and transmitting identification, location, biometric, reproduction, nutrition, behavior, activity, vital signs and temperature information from animals, and for the measurement, quality control and assurance of animal milk, meat processing, agriculture and livestock farming; movement, acceleration temperature, photoelectric, location and direction sensors, electronic and radio frequency identification tags and microchips for scientific use to be worn by, or implanted in, animals, to gather identification, location, biometric, reproduction, nutrition, behavior, activity, vital signs and temperature data; electronic and radio frequency identification tags for animals; data processing and analysis apparatus, in particular computerized and electronic monitoring systems for monitoring animals and image and video processing equipment and systems; computerized tracking systems, attendance recorders, monitoring and recording devices and apparatus and animal tracking devices; parts and fittings for all the aforesaid goods
(3) Livestock identification tags (1) Design, development, installation and maintenance of computer programs and database software in the field of identification and management of animals, animal behavior, animal activity, milk measurement and milk quality control; software as a service featuring software, and platform as a service featuring computer software platforms, for collecting, analyzing, monitoring, managing, sharing and transmitting identification, location, biometric, reproduction, nutrition, behavior, activity, vital signs and temperature information from animals, and for the measurement, quality control and assurance of animal milk, meat processing, agriculture and livestock farming; advisory and consultancy services in relation to the aforementioned services
(2) Providing information about veterinary preparations for cattle; Veterinary services in the nature of implanting of sensors, tags and microchips into animals, for purposes of collecting, analyzing, monitoring, managing, sharing and transmitting identification, location, biometric, reproduction, nutrition, behavior, activity, vital signs and temperature information, and for the measurement, quality control and assurance of animal milk, meat processing, agriculture and livestock farming; technical consultation in the fields of feeding and raising animals; veterinary services
05 - Pharmaceutical, veterinary and sanitary products
06 - Common metals and ores; objects made of metal
09 - Scientific and electric apparatus and instruments
20 - Furniture and decorative products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Veterinary preparations
(2) Downloadable computer software, computer hardware, encoders, scanners, integrated circuits, radio frequency identification tag readers, readers, prerecorded magnetic data carriers all for collecting, analyzing, monitoring, managing, sharing and transmitting identification, location, biometric, reproduction, nutrition, behavior, activity, vital signs and temperature information from animals, and for the measurement, quality control and assurance of animal milk, meat processing, agriculture and livestock farming; movement, acceleration temperature, photoelectric, location and direction sensors, electronic and radio frequency identification tags and microchips for scientific use to be worn by, or implanted in, animals, to gather identification, location, biometric, reproduction, nutrition, behavior, activity, vital signs and temperature data; electronic and radio frequency identification tags for animals; data processing and analysis apparatus, in particular computerized and electronic monitoring systems for monitoring animals and image and video processing equipment and systems; computerized tracking systems, attendance recorders, monitoring and recording devices and apparatus and animal tracking devices; parts and fittings for all the aforesaid goods
(3) Livestock identification tags (1) Design, development, installation and maintenance of computer programs and database software in the field of identification and management of animals, animal behavior, animal activity, milk measurement and milk quality control; software as a service featuring software, and platform as a service featuring computer software platforms, for collecting, analyzing, monitoring, managing, sharing and transmitting identification, location, biometric, reproduction, nutrition, behavior, activity, vital signs and temperature information from animals, and for the measurement, quality control and assurance of animal milk, meat processing, agriculture and livestock farming; advisory and consultancy services in relation to the aforementioned services
(2) Providing information about veterinary preparations for cattle; Veterinary services in the nature of implanting of sensors, tags and microchips into animals, for purposes of collecting, analyzing, monitoring, managing, sharing and transmitting identification, location, biometric, reproduction, nutrition, behavior, activity, vital signs and temperature information, and for the measurement, quality control and assurance of animal milk, meat processing, agriculture and livestock farming; technical consultation in the fields of feeding and raising animals; veterinary services
The present invention provides canine antibodies that bind to canine interleukin-13 (canine IL-13) that have a high binding affinity for canine IL-13 and that can block the binding of canine IL-13 to the canine Type II heterodimer IL-4 receptor. The present invention also provides methods of using the antibodies of the present invention in the treatment of atopic dermatitis in dogs.
A61P 37/00 - Drugs for immunological or allergic disorders
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
alpha alpha (canine IL-4Rα or cIL-4Rα) of the canine Type II heterodimer IL-4 receptor. The present invention also provides methods of using the antibodies of the present invention in the treatment of atopic dermatitis in dogs.
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Veterinary preparations for the prevention and treatment of
dermatological disorders for companion animals. Provision of veterinary information, also via websites.
A system for opening ampoules, the system comprising a beam comprising at least one opening for receiving part of an ampoule and an ampoule carrier for holding one or more ampoules. The system is configured to rotate the beam relative to the carrier, such that the rotation causes opposite sides of said opening to apply pressure to said received ampoule held by the carrier, to thereby break off said part of the ampoule received by the opening.
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable computer software for data collection, healthcare tracking, reporting and analysis relating to healthcare of aquatic species Online non-downloadable computer software for data collection, healthcare tracking, reporting and analysis relating to healthcare of aquatic species Medical information services relating to healthcare of aquatic species
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Veterinary preparations for the prevention and treatment of dermatological disorders for companion animals. (1) Provision of veterinary information, also via websites.
62.
PROCESSES FOR MAKING ENDOCHIN-LIKE QUINOLONES FROM ALKYL 3-(3-ALKOXYPHENYL)AMINO)-2-(4-(4-ALKOXY)PHENOXY)PHENYL)BUT-2-ENOATE
The present invention relates to a vaccine for use in a method of inducing an immune response in a canine against infectious canine hepatitis and/or infectious tracheobronchitis. To combine a convenient way of administering the vaccine and a good protection against ICH and infectious tracheobronchitis, the vaccine is a first vaccine comprising a canine adenovirus type 2, and the method comprises - administration of an immunologically effective dose of the first vaccine, - subcutaneous administration of an immunologically effective dose of a second vaccine comprising a canine adenovirus type 2 7-42 days after the first vaccine, and - oral administration of an immunologically effective dose of a third vaccine comprising a canine adenovirus type 2 10-14 months after the first vaccine.
C07D 215/233 - Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
C07C 69/67 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
67.
PROCESSES FOR MAKING ENDOCHIN-LIKE QUINOLONES FROM ALKYL 3-(3-ALKOXYPHENYL)AMINO)-2-(4-(4-ALKOXY)PHENOXY)PHENYL)BUT-2-ENOATE
C07C 225/16 - Compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly-bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (Spain)
ÁLLATORVOSTUDOMÁNYI KUTATÓINTÉZET (Hungary)
UNIVERSIDAD COMPLUTENSE DE MADRID (Spain)
INTERVET INTERNATIONAL B.V. (Netherlands)
Inventor
Rueda Pérez, Paloma
Sastre Antoranz, Patricia
Venteo Moreno, Ángel
González García, Gabriela
Arias Neira, María Luisa
Gallardo Frontaura, Carmina
Fernández Piñero, Jovita
Zádori, Zoltán
Mészáros, István
Olasz, Ferenc
Sánchez-Vizcaíno Rodríguez, José Manuel
Barroso Arévalo, Sandra
Barasona García-Arévalo, José Ángel
Kosowska, Aleksandra
Van Den Born, Erwin
Abstract
The present invention relates to an in vitro diagnostic method to differentiate African Swine Fever Virus (ASFV) infected animals from animals which have been vaccinated against ASFV using an immunogenic composition comprising an attenuated ASFV in which the EP153R gene and the EP402R gene have been inactivated and wherein the region of the ASFV genome comprising the EP402R and the EP153R genes is replaced by a heterologous gene.
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (Spain)
ÁLLATORVOSTUDOMÁNYI KUTATÓINTÉZET (Hungary)
UNIVERSIDAD COMPLUTENSE DE MADRID (Spain)
GOLD STANDARD DIAGNOSTICS MADRID, S.A. (Spain)
Inventor
Van Den Born, Erwin
Arias Neira, María Luisa
Gallardo Frontaura, Carmina
Fernández Piñero, Jovita
Zádori, Zoltán
Mészáros, István
Olasz, Ferenc
Sánchez-Vizcaíno Rodríguez, José Manuel
Barroso Arévalo, Sandra
Barasona García-Arévalo, José Ángel
Kosowska, Aleksandra
Rueda Pérez, Paloma
Abstract
The present invention relates to African Swine Fever (ASF) attenuated viruses wherein the genes EP402R and EP153R have been inactivated, which can be used as a vaccine. The attenuated viruses protect pigs against subsequent challenge with virulent virus. The present invention also relates to the use of such attenuated viruses to treat and/or prevent ASF.
05 - Pharmaceutical, veterinary and sanitary products
16 - Paper, cardboard and goods made from these materials
Goods & Services
(1) Pharmaceuticals for the treatment of medical conditions in poultry and vaccines for poultry
(2) Informational bulletins relating to the poultry industry
The present invention regards a new recombinant HVT (rHVT) construct, useful as multivalent vector vaccine for poultry. The rHVT comprises 4 heterologous genes from poultry pathogens: the VP2 gene from IBDV, the F gene from NDV, and the gD and gI genes from ILTV. The VP2 and F genes are inserted in the Us genome region of the rHVT. The gD-gI genes are inserted in the UL genome region, between the UL54 and the LORF3 genes. The new rHVT-VP2-F-gD-gI proved to be genetically stable in vitro and in vivo, and expressed all inserted genes well. Also it was an effective vaccine against severe challenge infections with NDV, IBDV, and ILTV.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Veterinary preparations and substances for the prevention and treatment of dermatological disorders for companion animals, namely bacterial skin infections, fungal skin infections, viral skin infections, parasitic skin infections, psoriasis, eczema, and dermatitis
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Veterinary preparations and substances for the prevention and treatment of dermatological disorders for companion animals, namely bacterial skin infections, fungal skin infections, viral skin infections, parasitic skin infections, psoriasis, eczema, and dermatitis
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Veterinary preparations and substances for the prevention and treatment of dermatological disorders for companion animals, namely bacterial skin infections, fungal skin infections, viral skin infections, parasitic skin infections, psoriasis, eczema, and dermatitis
The invention is directed to a method to detach ectoparasites from fish in water. It was found that a fish anaesthetic agent in the form of an emulsion detaches the ectoparasites from the fish in the water. The method can be used on its own or it can be combined with a mechanical ectoparasite removal treatment.
A01N 65/28 - Myrtaceae [Myrtle family], e.g. teatree or clove
A01N 31/16 - Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
A61K 36/61 - Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
Disclosed is a novel pharmaceutical composition for the treatment of ear infections in an animal with a single dose administration comprising a gentamicin antibiotic, a posaconazole antifungal and a mometasone anti-inflammatory.
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61K 9/00 - Medicinal preparations characterised by special physical form
The present invention relates to the fields of veterinary medicine and virology and provides a vaccine against leishmaniasis. In particular, the invention relates to an isolated polynucleotide comprising (i) a first expression cassette comprising a nucleic acid encoding heat shock protein (hsp) 65, and (ii) a second expression cassette comprising a nucleic acid encoding LACK (Leishmania homologue of receptors for activated C kinase). In other embodiments, the invention relates to a DNA plasmid comprising the polynucleotide, a DNA vaccine for use in the treatment of leishmaniasis, and a method of immunizing a subject against an infection with leishmaniasis.
The present invention relates to liquid vaccine composition comprising a live virus and a natural deep-eutectic solvent (NADES) as the carrier. The carrier additionally comprises an additive selected from methionine and (hydroxy)ectoine. The additive is able to reduce the loss of virus titre over time, upon storage in a NADES-based liquid vaccine composition having up to 50 % w/w of water. Such compositions are less viscous which is favourable for the manufacture of the carrier, and the formulation and use of the liquid vaccine.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
The current invention provides the use compounds of Formula (I) which are JAK inhibitors, and as such for the treatment of JAK-1 mediated diseases such as atopic- and allergic dermatitis in young animals.
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
An injectable pharmaceutical composition for treating a bacterial infection in an animal comprising an effective amount of a compound of Formula (I) or salt thereof, and a pharmaceutically acceptable carrier, wherein the injectable pharmaceutical composition is both efficacious and safe.
The present invention relates to the field of vaccinology, more specifically of veterinary vaccinology. In particular, the invention relates to an adjuvant composition comprising an emulsion of water, tocopherol or a pharmaceutically acceptable ester thereof, and a polyethoxyethylene cetostearyl ether as an emulsifier. Said adjuvant composition can be used for formulating a vaccine, particularly an emulsion vaccine, comprising a bacterial, parasitic, or viral antigen. The resulting vaccine composition can be used in a method of protecting a human or animal target against infection and/or disease caused by a pathogen, particularly caused by a bacterium, parasite or virus. The invention further relates to methods for the manufacture of such adjuvant compositions and for the manufacture of such vaccine composition.
C07C 211/27 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
C07C 259/06 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 271/22 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
C07D 213/00 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
C07D 213/36 - Radicals substituted by singly-bound nitrogen atoms
C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
98.
CANINIZED ANTIBODIES TO CANINE INTERLEUKIN-31 RECEPTOR ALPHA 1
The present invention provides caninized mouse antibodies to canine IL-31 receptor alpha that have a high binding affinity for canine IL-31 receptor alpha, and that can block the binding of canine IL-31 to canine IL-31 receptor alpha. The present invention further provides the use of the antibodies for the treatment of atopic dermatitis in dogs.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The present invention provides caninized and felinized anti-human NGF antibodies that have a high binding affinity for canine NGF. The invention also relates to use of these antibodies in the treatment of pain in canines, felines, and other companion animals.
The present invention provides caninized mouse antibodies to canine IL-31 receptor alpha that have a high binding affinity for canine IL-31 receptor alpha, and that can block the binding of canine IL-31 to canine IL-31 receptor alpha. The present invention further provides the use of the antibodies for the treatment of atopic dermatitis in dogs.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C07K 14/715 - ReceptorsCell surface antigensCell surface determinants for cytokinesReceptorsCell surface antigensCell surface determinants for lymphokinesReceptorsCell surface antigensCell surface determinants for interferons
