Instituto Nacional de Tecnologia Agropecuaria

Argentina

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IPC Class
A01H 5/10 - Seeds 5
A61K 39/00 - Medicinal preparations containing antigens or antibodies 5
A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy 4
C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses 4
C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells 4
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Registered / In Force 21
Found results for  patents

1.

AQUEOUS BIOCIDE FORMULATION

      
Application Number US2023030222
Publication Number 2025/038079
Status In Force
Filing Date 2023-08-15
Publication Date 2025-02-20
Owner
  • INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)
  • RIZOBACTER USA LLC (USA)
Inventor
  • Canciani, Wilter
  • Faura, Andres, Ignacio
  • Gasoni, Amelia, Laura
  • Barrera, Viviana, Andrea
  • Rojo, Rodrigo, Alejandro

Abstract

TrichodermaTrichoderma and an aqueous solution of polyethylene glycol with a molar mass of between 50 and 1200Da, between 1 and 50% by mass. In addition, it describes methods for the protection of agricultural crops through the application of the developed formulation.

IPC Classes  ?

  • A01N 63/30 - Microbial fungiSubstances produced thereby or obtained therefrom
  • A01C 1/06 - Coating or dressing seed
  • A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
  • A01N 25/10 - Macromolecular compounds
  • A01N 29/10 - Halogen attached to an aliphatic side chain of an aromatic ring system
  • A01P 3/00 - Fungicides
  • A01P 7/04 - Insecticides
  • C12N 1/04 - Preserving or maintaining viable microorganisms

2.

METHODS AND ASSAYS FOR IDENTIFYING, CREATING, AND CULTIVATING DISEASE-RESISTANT PEANUT LINES

      
Application Number US2024040312
Publication Number 2025/034481
Status In Force
Filing Date 2024-07-31
Publication Date 2025-02-13
Owner
  • HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY (USA)
  • INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)
Inventor
  • Clevenger, Josh
  • Korani, Walid
  • Baldessari, Jorge, Javier

Abstract

The present disclosure is directed to methods of genetically detecting or generating a peanut line that is resistant to peanut smut infection. The disclosure also relates to cultivation of smut resistant peanut lines and the cessation or prevention of peanut smut in a given geographic area.

IPC Classes  ?

  • A01H 5/10 - Seeds
  • G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

3.

METHODS AND ASSAYS FOR IDENTIFYING, CREATING, AND CULTIVATING DISEASE-RESISTANT PEANUT LINES

      
Application Number 18790193
Status Pending
Filing Date 2024-07-31
First Publication Date 2025-02-06
Owner
  • HudsonAlpha Institute for Biotechnology (USA)
  • Instituto Nacional de Tecnologia Agropecuaria (Argentina)
Inventor
  • Clevenger, Josh
  • Korani, Walid
  • Baldessari, Jorge Javier

Abstract

The present disclosure is directed to methods of genetically detecting or generating a peanut line that is resistant to peanut smut infection. The disclosure also relates to cultivation of smut resistant peanut lines and the cessation or prevention of peanut smut in a given geographic area.

IPC Classes  ?

  • A01H 1/00 - Processes for modifying genotypes
  • A01H 5/10 - Seeds
  • A01H 6/54 - Leguminosae or Fabaceae, e.g. soybean, alfalfa or peanut
  • C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection

4.

DNA CONSTRUCT FOR STABLY PRODUCING EMPTY CAPSIDS OF THE FOOT-AND-MOUTH DISEASE VIRUS IN MAMMALIAN CELLS; PROCESSES, USES, AND COMPOSITIONS THEREOF

      
Application Number 18252212
Status Pending
Filing Date 2021-11-09
First Publication Date 2024-01-11
Owner
  • Instituto Nacional de Tecnologia Agropecuaria (Argentina)
  • National Research Council of Canada (Canada)
Inventor
  • Mignaqui, Ana Clara
  • Wigodorovitz, Andres
  • Durocher, Yves

Abstract

Methods and compositions for increasing the production of large amounts of empty capsids of the foot-and-mouth disease virus (FMDV) in a stable manner in mammalian cells by regulating the expression of FMDV 3C protease. The instant methods and compositions are based on the fact that a decreased expression of 3C protease results in a reduced cell toxicity and an increased synthesis of viral capsid proteins, as well as production of recombinant empty capsids. The invention provides recombinant plasmids that direct the expression of P1, 3C, and the use of the plasmids for producing new stable cell lines capable of generating high titers of FMDV empty capsids. The invention provides methods for regulating the expression of the FMDV 3C protease gene at a transcriptional and translational level in order to achieve the required process level of 3C protease for the selection process, as well as the production process.

IPC Classes  ?

  • C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
  • C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
  • C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
  • C12N 7/04 - Inactivation or attenuationProducing viral sub-units

5.

LLAMA-DERIVED NANOBODIES BINDING THE SPIKE PROTEIN OF NOVEL CORONAVIRUS SARS-COV-2 WITH NEUTRALIZING ACTIVITY

      
Application Number US2021064662
Publication Number 2022/140422
Status In Force
Filing Date 2021-12-21
Publication Date 2022-06-30
Owner
  • CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET) (Argentina)
  • INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA (Argentina)
  • VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (USA)
Inventor
  • Parreño, Gladys Viviana
  • Ibañez, Lorena Itati
  • Bok, Marina
  • Pavan, Florencia
  • Malito, Juan Pablo
  • Wigdorovitz, Andrés
  • Marcoppido, Gisela
  • Franco, Diego
  • Baumeister, Elsa
  • Schammas, Juan Manuel
  • Yuan, Lijuan
  • Auguste, Jonathan

Abstract

This disclosure is related to llama-derived nanobodies of which the corresponding sequences are provided, corresponding to the variable domain (VHH) of llama heavy chain antibodies recognizing epitopes of the Spike protein of SARS-CoV-2, some of them, directed to the receptor binding domain, RBD. The nanobodies disclosed herein have important scientific significance and application prospects, they can be labeled or fused with fluorochromes and enzymes to be used as reagents for immunodetection of the virus. Most importantly, the disclosed nanobodies can be used in the development of a bio-drug for the prevention and clinical treatment of infection and diseases caused by SARS-CoV-2.

IPC Classes  ?

6.

DNA CONSTRUCT FOR STABLY PRODUCING EMPTY CAPSIDS OF THE FOOT-AND-MOUTH DISEASE VIRUS IN MAMMALIAN CELLS; PROCESSES, USES, AND COMPOSITIONS THEREOF

      
Application Number CA2021051592
Publication Number 2022/094730
Status In Force
Filing Date 2021-11-09
Publication Date 2022-05-12
Owner
  • INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)
  • NATIONAL RESEARCH COUNCIL OF CANADA (Canada)
Inventor
  • Mignaqui, Ana Clara
  • Wigodorovitz, Andres
  • Durocher, Yves

Abstract

The present invention refers to methods and compositions for increasing the production of large amounts of empty capsids of the foot-and-mouth disease virus (FMDV) in a stable manner in mammalian cells by regulating the expression of FMDV 3C protease. The instant methods and compositions are based on the fact that a decreased expression of 3C protease results in a reduced cell toxicity and an increased synthesis of viral capsid proteins, as well as production of recombinant empty capsids. The invention provides recombinant plasmids that direct the expression of P1, 3C, and the use of said plasmids for producing new stable cell lines capable of generating high titers of FMDV empty capsids. The invention provides methods for regulating the expression of the FMDV 3C protease gene at a transcriptional and translational level in order to achieve the required process level of 3C protease for the selection process, as well as the production process.

IPC Classes  ?

  • C12N 15/86 - Viral vectors
  • A61K 39/135 - Foot-and-mouth disease virus
  • C07K 14/09 - Foot-and-mouth disease virus
  • C12N 15/42 - Foot-and-mouth disease virus
  • C12N 15/56 - Hydrolases (3) acting on glycosyl compounds (3.2), e.g. amylase, galactosidase, lysozyme
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
  • C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
  • C12N 9/50 - Proteinases
  • C12P 21/00 - Preparation of peptides or proteins

7.

HERBICIDE-RESISTANT RICE PLANTS, POLYNUCLEOTIDES ENCODING HERBICIDE-RESISTANT ACETOHYDROXYACID SYNTHASE LARGE SUBUNIT PROTEINS, AND METHODS OF USE

      
Application Number 17313747
Status Pending
Filing Date 2021-05-06
First Publication Date 2021-11-04
Owner Instituto Nacional De Technologia Agropecuaria (Argentina)
Inventor
  • Livore, Alberto
  • Prina, Alberto Raul
  • Singh, Bijay K.
  • Ascenzi, Robert
  • Whitt, Sherry R.

Abstract

Disclosed are methods for treating rice, including: providing a rice crop plant and at least one AHAS-inhibiting herbicide; applying an effective amount of the AHAS-inhibiting herbicide to the rice crop plant, post-emergence, to form a treated rice crop plant; and growing the treated rice crop plant. The applied AHAS-inhibiting herbicide may include 2-(4-isopropyl-4-methyl-5-oxo-2-imidiazolin-2-yl)-nicotinic acid, 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-quinolinecarboxylic acid, 5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-nicotinic acid, 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-(methoxymethyl)-nicotinic acid, or 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-methylnicotinic acid, a derivative thereof, or a mixture thereof.

IPC Classes  ?

  • C12N 9/10 - Transferases (2.)
  • C12N 9/88 - Lyases (4.)
  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

8.

H H antibodies directed to norovirus GI.1 and GII.4 and their use

      
Application Number 16854703
Grant Number 11325965
Status In Force
Filing Date 2020-04-21
First Publication Date 2020-09-10
Grant Date 2022-05-10
Owner
  • The United States of America, as represented by the Secretary, Department of Health and Human Services (USA)
  • Instituto Nacional De Technologia Agropecuaria (Argentina)
Inventor
  • Bok, Karin
  • Garaicoechea, Lorena Laura
  • Parreno, Viviana
  • Aguilar, Andrea Pamela
  • Bok, Marina
  • Green, Lisbeth Kim
  • Sosnovtsev, Stanislav Vladimirovich

Abstract

HH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.

IPC Classes  ?

  • G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

9.

Seeding assembly for seeding machine

      
Application Number 16705651
Grant Number 11770998
Status In Force
Filing Date 2019-12-06
First Publication Date 2020-06-11
Grant Date 2023-10-03
Owner
  • INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)
  • PLA S.A. (Argentina)
Inventor
  • Ferrari, Hernan Javier
  • Duranti, Luis

Abstract

A seed-sowing assembly, especially of rice, consisting of at least two single seeding units arranged in parallel and displaced longitudinally from each other, which allows a narrow separation between furrows, wherein each of said single units comprises a first pivoting support arm connected at one of its ends that supports a load regulator; and a second pivoting support arm connected to another end of the first support arm that supports at least one furrow-generating disc; at least one depth limiting wheel coupled to at least one furrow-generating disc; a seed contact wheel; and a third pivoting support arm connected to one end of the second support arm that supports two furrow-closing wheels. A seed-sowing machine comprising the seed-sowing assembly.

IPC Classes  ?

  • A01C 7/20 - Parts of seeders for conducting and depositing seed
  • A01C 5/06 - Machines for making or covering drills or furrows for sowing or planting

10.

Mecardonia plant named ‘INTAMEC003’

      
Application Number 15732153
Grant Number PP030298
Status In Force
Filing Date 2017-09-26
First Publication Date 2019-03-19
Grant Date 2019-03-19
Owner Instituto Nacional de tecnologia Agropecuaria (Argentina)
Inventor Greppi, Julian A.

Abstract

Mecardonia plant particularly distinguished by having yellow flower color, a very compact plant growth habit, and large leaves, is disclosed.

IPC Classes  ?

11.

HERBICIDE-RESISTANT RICE PLANTS, POLYNUCLEOTIDES ENCODING HERBICIDE-RESISTANT ACETOHYDROXYACID SYNTHASE LARGE SUBUNIT PROTEINS, AND METHODS OF USE

      
Application Number 16160268
Status Pending
Filing Date 2018-10-15
First Publication Date 2019-01-31
Owner INSTITUTO NACIONAL DE TECHNOLOGIA AGROPECUARIA (Argentina)
Inventor
  • Livore, Alberto
  • Prina, Alberto Raul
  • Singh, Bijay K.
  • Ascenzi, Robert
  • Whitt, Sherry R.

Abstract

The present disclosure provides a method for treating rice. The method comprises the steps of: providing a domestic rice crop plant and at least one AHAS-inhibiting herbicide selected from the group comprising a sulfonylurea herbicide, a sulfonyl carboxamide herbicide, an imidazolinone herbicide, a triazolopyrimidine herbicide, a pyrimidinyloxybenzoate herbicide, and a sulfonylaminocarbonyltriazolinone herbicide; applying an effective amount (measured in g Al/Ha) of one or more of the aforementioned herbicide to the domestic rice crop plant, post-emergence; thereby creating a treated rice plant; and growing the resulting treated rice plant.

IPC Classes  ?

  • C12N 9/10 - Transferases (2.)
  • C12N 9/88 - Lyases (4.)
  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

12.

Vaccine against bovine leukemia virus

      
Application Number 16006472
Grant Number 11154611
Status In Force
Filing Date 2018-06-12
First Publication Date 2019-01-03
Grant Date 2021-10-26
Owner
  • UNIVERSITÉDE LIÉGE (Belgium)
  • INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)
Inventor
  • Willems, Luc
  • Trono, Karina

Abstract

The invention relates to recombinant bovine leukemia viruses that have an attenuated phenotype and comprise a combination of at least two specific mutations. The invention also provides recombinant nucleic acids encoding such viruses, vectors comprising such nucleic acids, and host cells comprising such nucleic acids or vectors. The recombinant attenuated BLV viruses, recombinant nucleic acids, vectors and host cells allow for the preparation of improved vaccines, in particular vaccines suitable for the prophylactic treatment of BLV-associated diseases in subjects. The invention further provides methods for treating BLV-associated diseases in subjects and pharmaceutical compositions suitable for use in these methods.

IPC Classes  ?

  • A61K 39/21 - Retroviridae, e.g. equine infectious anemia virus
  • C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
  • C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
  • A61K 39/12 - Viral antigens
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

13.

Single domain VHH antibodies directed to norovirus GI.1 and GII.4 and their use

      
Application Number 15982998
Grant Number 10662238
Status In Force
Filing Date 2018-05-17
First Publication Date 2018-09-06
Grant Date 2020-05-26
Owner
  • The United States of America, as represented by the Secretary, Department of Health and Human Services (USA)
  • Instituto Nacional De Technologia Agropecuaria (Argentina)
Inventor
  • Bok, Karin
  • Garaicoechea, Lorena Laura
  • Parreno, Viviana
  • Aguilar, Andrea Pamela
  • Bok, Marina
  • Green, Lisbeth Kim
  • Sosnovtsev, Stanislav Vladimirovich

Abstract

HH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.

IPC Classes  ?

  • C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
  • G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • A61K 33/44 - Elemental carbon, e.g. charcoal, carbon black
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

14.

HERBICIDE-RESISTANT RICE PLANTS, POLYNUCLEOTIDES ENCODING HERBICIDE-RESISTANT ACETOHYDROXYACID SYNTHASE LARGE SUBUNIT PROTEINS, AND METHODS OF USE

      
Application Number 15591390
Status Pending
Filing Date 2017-05-10
First Publication Date 2018-01-11
Owner INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)
Inventor
  • Livore, Alberto
  • Prina, Alberto Raul
  • Singh, Bijay K.
  • Ascenzi, Robert
  • Whitt, Sherry R.

Abstract

Herbicide-resistant rice plants, isolated polynucleotides that encode herbicide resistant and wild-type acetohydroxy-acid synthase large subunit 1 (AHASL1) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described. Methods of using the polynucleotides to enhance the resistance of plants to imidazolinone herbicides, and methods for controlling weeds in the vicinity of herbicide-resistant plants are also described.

IPC Classes  ?

  • C12N 9/10 - Transferases (2.)
  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
  • C12N 9/88 - Lyases (4.)

15.

CHIMERIC POLYPEPTIDE, VACCINE AGAINST BABESIOSIS, IMMUNIZATION METHODS, DETECTION METHODS AND KIT

      
Application Number US2016038611
Publication Number 2016/209859
Status In Force
Filing Date 2016-06-22
Publication Date 2016-12-29
Owner
  • INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)
  • CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (Argentina)
  • INIS BIOTECH LLC (USA)
Inventor
  • Wilkowsky, Silvina, Elizabeth
  • Jaramillo Ortiz, José, Manuel
  • Del Medico Zajac, María, Paula
  • Calamante, Gabriela

Abstract

A chimeric polypeptide containing a fragment of MSA-2c antigen bound to a fragment of RAP-1 antigen bound to a fragment of HSP20 antigen, where the antigens are antigens of a Babesia genus parasite. For example, the chimeric polypeptide may be represented by an amino acid sequence which contains at least 89% identity in relation to SEQ ID N° 1. It shows a composition for a vaccine against babesiosis, immunization methods and detection methods.

IPC Classes  ?

  • C07K 14/44 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from protozoa
  • A61K 39/018 - Babesia antigens, e.g. Theileria antigens

16.

HH antibodies directed to norovirus GI.1 and GII.4 and their use

      
Application Number 14889774
Grant Number 10000556
Status In Force
Filing Date 2014-05-09
First Publication Date 2016-04-14
Grant Date 2018-06-19
Owner
  • THE UNITED STATES OF AMERICA, as represented by the Secretary, Dept. of Health and Human Services (USA)
  • INSTITUTO NACIONAL DE TECHNOLOGIA AGROPECUARIA (Argentina)
Inventor
  • Bok, Karin
  • Garaicoechea, Lorena Laura
  • Parreno, Viviana
  • Aguilar, Andrea Pamela
  • Bok, Marina
  • Green, Lisbeth Kim
  • Sosnovtsev, Stanislav Vladimirovich

Abstract

HH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.

IPC Classes  ?

  • C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
  • G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

17.

Vaccine against bovine leukemia virus

      
Application Number 14832863
Grant Number 10029006
Status In Force
Filing Date 2015-08-21
First Publication Date 2016-02-18
Grant Date 2018-07-24
Owner INSTITUTO NACIONAL DE TECHNOLOGÍA AGROPECUARIA (Argentina)
Inventor
  • Willems, Luc
  • Trono, Karina

Abstract

The invention relates to recombinant bovine leukemia viruses that have an attenuated phenotype and comprise a combination of at least two specific mutations. The invention also provides recombinant nucleic acids encoding such viruses, vectors comprising such nucleic acids, and host cells comprising such nucleic acids or vectors. The recombinant attenuated BLV viruses, recombinant nucleic acids, vectors and host cells allow for the preparation of improved vaccines, in particular vaccines suitable for the prophylactic treatment of BLV-associated diseases in subjects. The invention further provides methods for treating BLV-associated diseases in subjects and pharmaceutical compositions suitable for use in these methods.

IPC Classes  ?

  • A61K 39/21 - Retroviridae, e.g. equine infectious anemia virus
  • C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
  • C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
  • A61K 39/12 - Viral antigens
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

18.

Scarifier for deep strip-tillage

      
Application Number 14539529
Grant Number 10028421
Status In Force
Filing Date 2014-11-12
First Publication Date 2015-05-14
Grant Date 2018-07-24
Owner INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA (Argentina)
Inventor
  • Tesouro, Mario Omar
  • Donato, Lidia Beatriz
  • D'Amico, Juan Pablo
  • Roba, Marcos Andrés
  • Fernández De Ullivarri, Enrique
  • Romito, Angel

Abstract

c) are mounted, the lower ends of which are located at different heights, with the depth below the ground (d) being greater toward the rear of the scarifier. The scarifier preferably incorporates a fertilization system.

IPC Classes  ?

  • A01B 13/08 - Ploughs or like machines for special purposes for working subsoil
  • A01C 23/02 - Special arrangements for delivering the liquid directly into the soil
  • A01B 13/14 - Ploughs or like machines for special purposes for working soil in two or more layers

19.

Procedure and facility for grain moisture control

      
Application Number 13911978
Grant Number 09714790
Status In Force
Filing Date 2013-06-06
First Publication Date 2014-12-11
Grant Date 2017-07-25
Owner Instituto Nacional De Techologia Argopecuaria (Argentina)
Inventor
  • Bartosik, Ricardo
  • De La Torre, Diego

Abstract

A facility for controlling moisture in grains provided with a grain storage silo conveniently installed on a hard flat floor and inside of which a raised floor drilled with air passageways is provided, determining an air chamber inside the silo and below the perforated floor, into which previously conditioned air is blown by an air heater, wherein the control of hot air blowing times is determined based on modeling and calculating carried out by a programmable controller operatively connected to an ambient air temperature sensor located outside the silo, an ambient relative humidity sensor located outside the silo and a temperature air sensor located into the air chamber inside the silo, thereby causing the application of different stages of drying, rewetting and maintenance of the first bottom layer of grain, ranging between an upper and lower moisture limits narrowing around the desired moisture while the drying progress, leading to an homogeneous final moisture content of all the grain bulk.

IPC Classes  ?

  • F26B 23/02 - Heating arrangements using combustion heating
  • F26B 25/10 - Floors, roofs, or bottomsFalse bottoms
  • F26B 21/08 - Humidity
  • F26B 9/06 - Machines or apparatus for drying solid materials or objects at rest or with only local agitationDomestic airing cupboards in stationary drums or chambers
  • F26B 25/22 - Controlling the drying process in dependence on liquid content of solid materials or objects

20.

SINGLE-DOMAIN VHH ANTIBODIES DIRECTED TO NOROVIRUS GI.1 AND GII.4 AND THEIR USE

      
Application Number US2014037520
Publication Number 2014/183052
Status In Force
Filing Date 2014-05-09
Publication Date 2014-11-13
Owner
  • THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPART OF HEALTH AND HUMAN SERVICES (USA)
  • INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)
Inventor
  • Bok, Karin
  • Garaicoechea, Lorena, Laura
  • Parreno, Viviana
  • Aguilar, Andrea, Pamela
  • Bok, Marina
  • Green, Lisbeth, Kim
  • Sosnovtsev, Stanislav, Vladimirovich

Abstract

Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.

IPC Classes  ?

  • A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
  • C07K 16/08 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses
  • G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • A61P 31/12 - Antivirals
  • A61P 31/14 - Antivirals for RNA viruses
  • C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses

21.

VACCINE AGAINST BOVINE LEUKEMIA VIRUS

      
Application Number EP2014053855
Publication Number 2014/131844
Status In Force
Filing Date 2014-02-27
Publication Date 2014-09-04
Owner
  • UNIVERSITÉ DE LIÈGE (Belgium)
  • INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA (Argentina)
Inventor
  • Willems, Luc
  • Trono, Karina

Abstract

The invention relates to recombinant bovine leukemia viruses that have an attenuated phenotype and comprise a combination of at least two specific mutations. The invention also provides recombinant nucleic acids encoding such viruses, vectors comprising such nucleic acids, and host cells comprising such nucleic acids or vectors. The recombinant attenuated BLV viruses, recombinant nucleic acids, vectors and host cells allow for the preparation of improved vaccines, in particular vaccines suitable for the prophylactic treatment of BLV-associated diseases in subjects. The invention further provides methods for treating BLV-associated diseases in subjects and pharmaceutical compositions suitable for use in these methods.

IPC Classes  ?

  • A61K 39/21 - Retroviridae, e.g. equine infectious anemia virus
  • C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
  • C07K 16/04 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies from milk
  • C07K 16/08 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses
  • A01K 67/027 - New or modified breeds of vertebrates

22.

Modified surface topography for an agricultural tool

      
Application Number 14055489
Grant Number 09137937
Status In Force
Filing Date 2013-10-16
First Publication Date 2014-04-17
Grant Date 2015-09-22
Owner INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)
Inventor
  • Canzian, Adrian Marcelo
  • Crisanti, Jose
  • Monti, Carlos Alberto
  • Favret, Eduardo Alfredo
  • Morras, Hector Jose Maria
  • Romito, Angel
  • Roba, Marcos Andres
  • D'Amico, Juan Pablo
  • Tesouro, Mario Omar

Abstract

A modified surface topography for agricultural tools includes dimples are arranged in a parallelogram (hexagonal) pattern, the morphological unit of which is an equilateral triangle. This surface pattern can be applied to various tools which are impeded by the traction of the soil.

IPC Classes  ?

  • A01B 35/32 - Other machines for working soil with special additional arrangements
  • A01B 76/00 - Parts, details or accessories of agricultural machines or implements, not provided for in groups
  • A01B 1/02 - SpadesShovels
  • A01B 15/02 - Plough bladesFixing the blades
  • A01B 15/16 - DiscsScrapers for cleaning discsSharpening attachments
  • A01C 5/06 - Machines for making or covering drills or furrows for sowing or planting
  • A01B 35/20 - ToolsOther machines for working soil Details

23.

Insect-killing monitoring trap for mass capturing and controlling cotton boll weevils

      
Application Number 13934939
Grant Number 09402383
Status In Force
Filing Date 2013-07-03
First Publication Date 2014-01-09
Grant Date 2016-08-02
Owner Instituto Nacional de Tecnologia Agropecuaria (Argentina)
Inventor Bonacic Kresic, Ivan

Abstract

A trap for mass capturing and controlling the insect called “cotton boll weevil”, comprising a tubular central body (1) having a bottom section provided with holes (11), a housing formed by a perforated lid (7) and a base or bottom lid (3) provided with holes (3B) and further including one or more openings (12) to allow insect entering the housing from the bottom section (1); b) an insecticide dispenser section (4) inside the housing, c) a hole section for venting and discharging vapors (5) located at a position that is farther from the base or bottom lid than the insecticide dispenser (4); d) a perforated vessel (8) to contain an attractant diffuser (14) outside the housing and above it, and e) a closure (9) of the perforated vessel (8) at its upper end.

IPC Classes  ?

  • A01M 1/00 - Stationary means for catching or killing insects
  • A01M 1/02 - Stationary means for catching or killing insects with devices attracting the insects
  • A01M 1/10 - Traps
  • A01M 1/20 - Poisoning, narcotising, or burning insects

24.

Load transfer device for seed distribution systems in seeders and fertilizer machines

      
Application Number 13441758
Grant Number 08807057
Status In Force
Filing Date 2012-04-06
First Publication Date 2012-10-11
Grant Date 2014-08-19
Owner Instituto Nacional de Tecnologia Agropecuaria (Argentina)
Inventor
  • D'Amico, Juan Pablo
  • Tesouro, Mario Omar
  • Romito, Angel
  • Roba, Marcos Andres

Abstract

The movement along the ground in seed and fertilizer distribution systems of seeder and fertilizer machines is improved by a load transfer device comprising a deformable parallelogram-shaped structure attached to the machine tool holder bar at one end and to the distribution system at the other end, and a transfer rack that articulates in one of the parallelogram vertexes acting as a rocker arm. The rocker arm is connected at one end to the parallelogram and at the other end to at least one spring through a lever arm that extends downwardly and divergently, generating a crossing angle between the parallelogram lower un upper sides, creating a torque that varies not only for the spring tension by also for the ratio of the effective lengths of the involved lever arms.

IPC Classes  ?

  • A01C 14/00 - Methods or apparatus for planting not provided for in other groups of this subclass

25.

HERBICIDE-RESISTANT RICE PLANTS, POLYNUCLEOTIDES ENCODING HERBICIDE RESISTANT ACETOHYDROXYACID SYNTHASE LARGE SUBUNIT PROTEINS, AND METHODS OF USE

      
Application Number 13418018
Status Pending
Filing Date 2012-03-12
First Publication Date 2012-09-13
Owner INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)

Abstract

Herbicide-resistant rice plants, isolated polynucleotides that encode herbicide resistant and wild-type acetohydroxyacid synthase large subunit 1 (AHASL1) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described. Methods of using the polynucleotides to enhance the resistance of plants to imidazolinone herbicides, and methods for controlling weeds in the vicinity of herbicide-resistant plants are also described.

IPC Classes  ?

  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
  • C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
  • A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy
  • A01P 13/00 - HerbicidesAlgicides
  • A01C 1/06 - Coating or dressing seed
  • C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
  • A01N 43/50 - 1,3-DiazolesHydrogenated 1,3-diazoles
  • C12N 15/29 - Genes encoding plant proteins, e.g. thaumatin
  • A01H 5/10 - Seeds

26.

RICE PLANTS HAVING INCREASED TOLERANCE TO IMIDAZOLINONE HERBICIDES

      
Application Number 13420958
Status Pending
Filing Date 2012-03-15
First Publication Date 2012-07-05
Owner INSTITUTO NACIONAL DE TECHNOLOGIA AGROPECUARIA (Argentina)

Abstract

The present invention is directed to plants having increased tolerance to an imidazolinone herbicide. More particularly, the present invention includes rice plants containing at least one variant AHAS nucleic acid such as an imidazolinone tolerant IMINTA 1, 4 or 5 lines comprising an alanine to threonine substitution as compared to the wild-type AHAS. The present invention also includes seeds produced by these rice plants and methods of controlling weeds in the vicinity of these rice plants.

IPC Classes  ?

  • A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy
  • A01P 13/00 - HerbicidesAlgicides
  • C12N 15/60 - Lyases (4)
  • A01N 43/50 - 1,3-DiazolesHydrogenated 1,3-diazoles
  • C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
  • A01H 5/10 - Seeds

27.

PROCEDURE TO ESTIMATE ORGANOLEPTIC PARAMETERS OF TISSUES OF ANIMAL ORIGIN AND DEVICE FOR CARRYING OUT SAME

      
Application Number IB2009054572
Publication Number 2010/044080
Status In Force
Filing Date 2009-10-16
Publication Date 2010-04-22
Owner
  • CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) (Argentina)
  • UNIVERSIDAD NACIONAL DE TUCUMÁN (Argentina)
  • INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA (Argentina)
  • INIS BIOTECH LLC (USA)
Inventor
  • Aristizabal Botero, William
  • Gómez Sánchez, John Alexander
  • Giraldo Osorio, Oscar Hernán
  • Felice, Carmelo José

Abstract

Procedure and device to estimate organoleptic parameters of tissues of animal origin, i.e. meat allowing to measure toughness, tenderness, or muscle tone for situations where qualification is required. It is based on the measurement of dielectric permittivity in a frequency spectrum and in computing muscle bidirectional electrical anisotropy index (BEAI). The device has a specially designed cell where the muscle sample (2, 7) is placed and is put in contact with the metallic electrodes (8) forming an impedance measurement system (4-6; 9-12) in the frequency range of 0.1 Hz to 10 MHz, and the permittivity (ε) value is thus calculated along with the bidirectional electrical anisotropy index. The bidirectional electrical anisotropy index is displayed or communicated to a PC (11) for monitoring and telemetry functions. The advantage of this device over the alternatives suggested in the literature is the insensibility to muscle conductivity changes. The bidirectional electrical anisotropy index then correlates with organoleptic tenderness, as determined by a sensorial evaluation panel.

IPC Classes  ?

  • G01N 33/12 - MeatFish
  • G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
  • G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance

28.

HERBICIDE-RESISTANT RICE PLANTS, POLYNUCLEOTIDES ENCODING HERBICIDE-RESISTANT ACETOHYDROXYACID SYNTHASE LARGE SUBUNIT PROTEINS, AND METHODS OF USE

      
Application Number 11816884
Status Pending
Filing Date 2006-02-28
First Publication Date 2010-02-04
Owner INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (Argentina)

Abstract

Herbicide-resistant rice plants, isolated polynucleotides that encode herbicide resistant and wild-type acetohydroxy-acid synthase large subunit 1 (AHASL1) polypeptides, and the amino acid sequences of these polypeptides, are described. Expression cassettes and transformation vectors comprising the polynucleotides of the invention, as well as plants and host cells transformed with the polynucleotides, are described. Methods of using the polynucleotides to enhance the resistance of plants to imidazolinone herbicides, and methods for controlling weeds in the vicinity of herbicide-resistant plants are also described.

IPC Classes  ?

  • A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
  • A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy
  • A01H 5/10 - Seeds
  • A01N 43/50 - 1,3-DiazolesHydrogenated 1,3-diazoles
  • A01N 47/34 - Ureas or thioureas containing the groups N—CO—N or N—CS—N containing the groups , e.g. biuretThio-analogues thereofUrea-aldehyde condensation products
  • A01N 43/54 - 1,3-DiazinesHydrogenated 1,3-diazines
  • A01N 43/653 - 1,2,4-TriazolesHydrogenated 1,2,4-triazoles
  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
  • C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
  • C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
  • C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
  • C12N 5/07 - Animal cells or tissues
  • C12N 5/04 - Plant cells or tissues
  • A01P 13/00 - HerbicidesAlgicides
  • A01H 1/00 - Processes for modifying genotypes
  • C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
  • C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
  • A01H 1/02 - Methods or apparatus for hybridisationArtificial pollination

29.

TRANSFER PLASMIDIC VECTOR AND RECOMBINANT CANARYPOX VIRUS

      
Application Number BR2007000087
Publication Number 2007/115385
Status In Force
Filing Date 2007-04-09
Publication Date 2007-10-18
Owner
  • INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA (Argentina)
  • BIOGÉNESIS BAGÓ SAÚDE ANIMAL LTDA. (Brazil)
Inventor
  • Calamante, Gabriela
  • Conte Grand, María Daniela
  • Carrillo, Elisa Cristina

Abstract

A recombinant virus from the canarypox virus (CNPV) is provided, being the virus capable of acting in vivo as an expression vector of foreign genes inserted in genomic regions non-essential for viral replication, that show genetic stability, wherein said genomic regions correspond to at least a gene selected from CNPV018 (SEQ ID No 1), CNPV048 (SEQ ID No 2) and CNPV134 (SEQ ID No 3) of the canarypox virus genome. A plasmidic transfer vector susceptible of homologous recombination with a canarypox virus is provided. Vaccines and immunization methods are also provided.

IPC Classes  ?

  • C12N 15/863 - Poxviral vectors, e.g. vaccinia virus
  • C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

30.

Rice plants having increased tolerance to imidazolinone herbicides

      
Application Number 10569576
Status Pending
Filing Date 2004-08-30
First Publication Date 2007-02-01
Owner Instituto Nacional de Technologia Agropecuaria (Argentina)

Abstract

The present invention is directed to plants having increased tolerance to an imidazolinone herbicide. More particularly, the present invention includes rice plants containing at least one variant AHAS nucleic acid such as an imidazolinone tolerant IMINTA 1, 4 or 5 lines comprising an alanine to threonine substitution as compared to the wild-type AHAS. The present invention also includes seeds produced by these rice plants and methods of controlling weeds in the vicinity of these rice plants.

IPC Classes  ?

  • A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy
  • C12N 5/04 - Plant cells or tissues
  • A01H 1/00 - Processes for modifying genotypes