The present invention relates to the field of polymeric matrix for haemostatic application. In particular, the Invention provides an efficient polymeric haemostatic device/bandage with high swelling rate, enhanced mechanical property and high blood clotting ability.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
A61L 15/42 - Use of materials characterised by their function or physical properties
A61L 15/60 - Liquid-swellable gel-forming materials, e.g. super-absorbents
The present invention discloses a system and method for extracting malware capability. The system comprises a malware execution subsystem configured to execute a malware application in an isolated computing environment, detect one or more changes in system instances and obtain one or more system application programming interface (API) calls and their execution timestamp data from the executed malware application, a malware activity capturing subsystem configured to sort the system API calls based on the obtained timestamp data, generate a trigram sequence from the sorted system API calls, process the trigram sequence to generate one or more feature vectors, a malware capability extraction subsystem configured to classify the received feature vectors based on one or more malignant capabilities of the executed malware and generate a threat report based on analysis of the classified malignant capabilities of the executed malware.
G06F 21/53 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by executing in a restricted environment, e.g. sandbox or secure virtual machine
G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
3.
2-AMINO BENZOPHENONE DERIVATIVES FOR TARGETED FERROPTOSIS INDUCTION IN CANCER THERAPY
The present invention discloses a novel class of covalent small molecules comprising 2-amino benzophenone derivatives for targeted ferroptosis induction in cancer cells. The present invention also includes strategies for target identification, hit-to-lead optimization, and combination therapies to enhance therapeutic efficacy. A synthesis and characterization of a library of unique organic structural scaffolds encompassing natural/unnatural amino acids, aromatic and heterocyclic linkers coupled with electrophilic units possessing diverse nucleophile reactivity profiles is provided. The molecules exhibit sub-micromolar to nanomolar inhibitory potency (IC50) when screened against a panel of cancer cell lines including MCF7 (breast cancer), MDA-MB-231 (triple negative breast cancer), 22Rv1 (Prostate), PC3, (prostate cancer), Jurkat J6 (acute T-cell Leukaemia), RPMI 8226 (B lymphocytes), U87MG (glioblastoma), HCT-116 (colon cancer) and A375 (melanoma)) and kidney cells (HEK293). The molecules exhibit potent antiproliferative effects across various cancer cell lines, offering a promising alternative to conventional chemotherapies with reduced side effects.
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
C07C 235/78 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
C07C 311/13 - Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
The present invention provides modified adeno-associated virus (AAV) vectors designed for gene therapy for treating hemophilia B The modified AAV vectors are obtained with enhanced transduction efficiency and immune evasion capabilities achieved through precise modifications at post-translational modification (PTM) sites on AAV8 and AAVrh10 capsids. The modified AAV vectors offer advantages including improved therapeutic efficacy at lower vector doses, similar immunogenicity profile as wild type AAV vectors, and versatility for treating hemophilia B and similar liver disorders (e.g., Gaucher's disease). The present invention further encompasses a method for manufacturing the modified AAV vectors, ensuring their precise and reliable production. The modified AAV vectors has potential for long-term gene expression and adaptability for other genetic disorders which makes the present invention a significant advancement in the field of gene therapy.
The present invention provides a gene therapy strategy for an effective breast cancer treatment Employing Adeno-associated virus (AAV) vectors, the present invention delivers an inducible Casp9 (iCasp9) suicide transgene, specifically triggering apoptosis in breast cancer cells irrespective of their cell cycle phase. The innovative approach of the present invention presents heightened cytotoxicity within heterogeneous tumor tissues, and its compatibility with combinatorial treatments amplifies its therapeutic potential. Leveraging the inherent safety of AAV vectors, this therapy minimizes the likelihood of drug resistance emergence. Demonstrated efficacy in inhibiting tumor growth and inducing apoptosis in preclinical breast cancer models underscores the promise of this AAV-mediated iCasp9 gene therapy as a transformative solution, poised to revolutionize breast cancer treatment with improved efficacy and reduced systemic toxicity.
A system and a method for terminating ransomware based on detection of anomalous data is disclosed. The system and the method comprise a registry activity monitoring subsystem, a file trap monitoring subsystem, a decision generating subsystem, and a termination subsystem. The registry activity monitoring subsystem is configured to generate first data and the file trap monitoring subsystem is configured to generate second data. The first data and the second data are transferred to the decision generating subsystem for retrieving Process IDs (PIDs) to initiate a ransomware termination process. Upon confirmation from the decision generating subsystem, the termination subsystem is configured to terminate the retrieved Process IDs (PIDs) to terminate the ransomware based on the detection of the anomalous data from one or more computing devices.
The present patent invention introduces an electrochemical sensor specifically designed for accurate detection of bilirubin levels in biological samples The sensor incorporates a unique electrode configuration consisting of two working electrodes (201), two counter electrodes (202), and a common reference electrode (203), all fabricated with gold-based trimetallic nanocomposites. The sensor further employs isolated chambers, enabling separate detection of direct and total bilirubin. The chambers are dry-casted with specific reagents to optimize the detection process. A covering layer (208), featuring a hydrophilic coating and non-hydrophilic outer layer, facilitates sample introduction via capillary action. A small vent opening ensures efficient air escape during sample entry. The fabrication process involves screen printing, drying, and layer attachment. The electrochemical sensor of the present invention provides improved accuracy and reliability, making it highly suitable for precise diagnosis and monitoring of medical conditions related to liver health.
G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
The present patent invention introduces an electrochemical sensor (200) specifically designed for accurate detection of bilirubin levels in biological samples The sensor incorporates a unique electrode configuration consisting of two working electrodes (201), two counter electrodes (202), and a common reference electrode (203), all fabricated with non-gold-based trimetallic nanocomposites. The sensor further employs isolated chambers, enabling separate detection of direct and total bilirubin. The chambers are dry-casted with specific reagents to optimize the detection process. A covering layer (208), featuring a hydrophilic coating and non- hydrophilic outer layer, facilitates sample introduction via capillary action. A small vent opening ensures efficient air escape during sample entry. The fabrication process involves screen printing, drying, and layer attachment. The electrochemical sensor (200) of the present invention provides improved accuracy and reliability, making it highly suitable for precise diagnosis and monitoring of medical conditions related to liver health.
G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
An assembly includes a frame configured to couple to a valve, an actuating arm movably coupled to the frame and configured to move a movable component of the valve to adjust a position of the movable component, and a biasing member coupled to the actuating arm and the frame. The biasing member is configured to bias the actuating arm in a first direction relative to the frame. The assembly further includes one or more shape memory alloy (SMA) elements coupled to the actuating arm and the frame. Responsive to an activation that causes the one or more SMA elements undergo a dimensional transformation, the one or more SMA elements are configured to operate against the biasing member to bias the actuating arm in a second direction opposite the first direction relative to the frame.
A system and method for kernel-level active darknet monitoring in a communication network is disclosed. The system receives TCP packets from initiator devices and determines dark internet protocol (IP) addresses in the packets by comparing destination IP address with a plurality of IP addresses stored in a dark IP pool. If the packets are determined to be destined for dark IP addresses, the system modifies flag and type in socket buffer and routing entry associated with packets. The system retrieves outbound interface IP addresses and creates a socket corresponding to the retrieved outbound interface IP addresses, for transmitting a SYN-ACK packet corresponding to the TCP packets. The system is configured to monitor dark IP addresses received through network traffic. Finally, the system outputs the SYN-ACK packet to initiator devices to establish a three-way handshake. The system receives an ACK from initiator devices (attackers) to establish a 3-way handshake.
An arrangement of an organic light emitting diode (OLED) assembly (100) is disclosed The OLED assembly (100) includes a plurality of OLEDs (102), a plurality of metal clips (104), a printed circuit board (106), and a plurality of external pins (108). The plurality of OLEDs (102) are printed, coated or evaporated on a glass substrate (602). The plurality of metal clips (104) are connected to the plurality of OLEDs (102) through the plurality of contact leads (202). The plurality of contact leads (202) are electrically connected with first side (502) of plurality of metal clips (104). The first set of plurality of through holes (402) allows second side (504) of plurality of metal clips (104) for electrical contact with the OLEDs (102). The second set of plurality of through holes (404) allows a plurality of external pins (108) to be inserted for external connection and powering to the OLEDs (102).
H01L 27/15 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components with at least one potential-jump barrier or surface barrier, specially adapted for light emission
H10K 59/95 - Assemblies of multiple devices comprising at least one organic light-emitting element wherein all light-emitting elements are organic, e.g. assembled OLED displays
12.
METHODS AND SIGNALING FOR ENABLING CARRIER PHASE-BASED POSITIONING IN A WIRELESS COMMUNICATION SYSTEM
Centre of Excellence in Wireless Technology (India)
Inventor
Saini, Jyotirmay
Masal, Abhijeet Abhimanyu
Gadhai, Shyam Vijay
Shankar, Shiv
Milleth, Jeniston Deviraj Klutto
Budhiraja, Rohit
Abstract
A method for positioning in a wireless communication system is described. The method comprises receiving, by a second node (102), a capability-request signal from a first node (106). The second node (102) transmits a capability-response signal to the first node (106). The second node (102) transmits an assistance information to the first node (106). The second node (102) transmits the configuration of the at least one reference signal to a third node (104). The second node (102) receives a reference signal from the third node (104). The second node (102) performs measurement on the reference signal and transmits report comprising the measurement to the first node (106), where the first node (106) estimates a position of the third node (104) based on the report received from the second node (102).
G01S 5/02 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations using radio waves
G01S 5/00 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations
H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management
A haptic tactile smart watch for the visually impaired is provided. The tactile smart watch comprises a watch case having a tactile digital interface. One or more tactile push buttons are configured on an outer circumference of the watch case. The one or more tactile push buttons activate one or more functions associated with the tactile smart watch. One or more touch sensitive indicators receive one or more touch inputs from a user input. Each of the one or more touch sensitive indicators generate one or more haptic feedback in response to the one or more touch inputs. A sensing module receives electrical signals corresponding to the identified specific actions from the one or more touch sensitive indicators, and senses one or more application parameters based on the received one or more electrical signals. The one or more application parameters are communicated, via haptic feedback, numerically to the user using touch sensitive indicators.
An optimized AAV vector for gene therapy of muscular dystrophy is provided. The optimized AAV vector includes a plurality of mutant AAV9 vectors and a microdystrophin transgene (p.AAV-CBA-kozak-μDys). The optimized AAV vector demonstrate increased transduction efficiency, gene expression levels, and can potentially achieve optimal therapeutic efficacy in humans at lower vector doses. The optimized AAV vector also demonstrate improved transduction and dystrophin gene expression in a mice model of Duchenne muscular dystrophy.
The present disclosure relates to the field of security systems and discloses a tamper detection device. The device (100) comprises at least one transducer (106,110), a power supply unit (114), a logical gate (112), a processing unit (104), and a tamper tag 102). The transducer (106,110) generates a trigger signal upon detection of a tamper event. The logical gate (112) is operable in an open state or a closed state. The processing unit (104) generates a tamper detection signal for changing the state of the logical gate (112) upon receiving the trigger signal or upon detecting loss of power supply from the power supply unit (114). The change in state of logical gate (112) is detected by a set of sensors (116), of the tamper tag (102), which in turn cause an LED indicator (118), of the tamper tag (102), to indicate the state of the device. An auxiliary capacitor (108) is configured to supply power to the processing unit (104) in the absence of the supply of power from the power supply unit (114).
G08B 13/24 - Electrical actuation by interference with electromagnetic field distribution
G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
H01Q 1/22 - SupportsMounting means by structural association with other equipment or articles
G08B 5/36 - Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electric transmissionVisible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electromagnetic transmission using visible light sources
16.
NETWORK-CONTROLLED REPEATER FOR COMMUNICATING SIGNALS TO BASE STATION AND USER EQUIPMENTS IN WIRELESS COMMUNICATION NETWORK
CENTRE OF EXCELLENCE IN WIRELESS TECHNOLOGY (India)
Inventor
Gadhai, Shyam Vijay
Saini, Jyotirmay
Budhiraja, Rohit
Maya, Deepak Padmanabhan
Dey, Priyanka
Abstract
A network-controlled repeater for communicating signals to at least one BS and at least one UE, is disclosed. The NCR includes a mobile terminal configured to: perform signaling exchange with at least one BS for an initial access and synchronization, and to receive at least one side control information (SCI) from the at least one BS. The SCI is at least a dynamic configuration. The SCI is received in at least one of: a dedicated control channel for the NCR scrambled using a dedicated RNTI for the SCI of the NCR. The NCR further includes a radio unit configured to: receive at least one signal of a first set of signals based on the SCI, and to transmit the at least one signal of the first set of signals based on at least one SCI.
A system for an ocular gene therapy is provided. The system includes one or more optimized transgenes. The one or more optimized transgenes include pAAV.CMV.CodOpt.RPE65 and pAAV.CMV.Kozak.RPE65. The optimized transgenes pAAV.CMV.CodOpt.RPE65 and pAAV.CMV.Kozak.RPE65 have shown to exhibit enhanced RPE65 gene expression when compared to wild type RPE65 gene transfer in suitable models. These optimized genes may enhance therapeutic response during LCA2 gene therapy. The present invention also provides a process for preparing the optimized transgene for an ocular gene therapy.
A formulation and method for treating prostate cancer is provided. The method includes use of bromodomain and extra-terminal domain inhibitors (BETi) or combination of BETi and anti-androgen drug to therapeutically target DLX1-positive advanced-stage prostate cancer patients. The formulation for treating prostate cancer relates to disrupting ERG/AR transcriptional circuitry with BETi in combination with anti-androgen drug to attenuate DLX1 expression and its downstream oncogenic effects. The BETi and the combination of BETi and anti-androgen drug yields 60% of tumor regression and remarkable reduction in distant metastases in the preclinical immunodeficient mice bearing DLX1-positive tumors.
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61K 31/4166 - 1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
A61P 13/08 - Drugs for disorders of the urinary system of the prostate
A wearable device with a smart timer (100) is disclosed. The wearable device (100) includes a touch-based dial interface on a front casing of the wearable device (100). The touch-based dial interface includes a set of touch-based hour sensors (104). The set of touch-based hour sensors (104) is positioned at standard hour markers. The touch-based dial interface also includes a tactile switch (106) placed at an outer periphery of the front casing. The tactile switch (106) is configured to receive a second set of touch inputs from the user for setting the timer. The wearable device (100) also includes a sensing module (610) communicatively coupled to the touch-based hour sensors (104) and the tactile switch (106). Such wearable device (100) helps in setting a small duration timer easily.
The system and method of converting high DC voltage input into low voltage output using DC/DC flyback converter using differential transformation technique. The said system comprises a primary winding of a transformer connected to the positive terminal of a DC supply. A primary power circuit including a MOSFET connected to the drain terminal of the MOSFET. Further, a pair of secondary winding of the transformer provided connected differentially to each other. The output voltage of the secondary side of the converter is based on the turn ratio of primary winding and the two secondary winding, wherein the two secondary windings are connected differentially with opposite polarity to each other.
H01F 27/34 - Special means for preventing or reducing unwanted electric or magnetic effects, e.g. no-load losses, reactive currents, harmonics, oscillations, leakage fields
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
The present invention relates to the field of polymeric matrix for haemostatic application. In particular, the Invention provides an efficient polymeric haemostatic device/ bandage with high swelling rate, enhanced mechanical property and high blood clotting ability.
An assembly includes a frame configured to couple to a valve, an actuating arm movably coupled to the frame and configured to move a movable component of the valve to adjust a position of the movable component, and a biasing member coupled to the actuating arm and the frame. The biasing member is configured to bias the actuating arm in a first direction relative to the frame. The assembly further includes one or more shape memory alloy (SMA) elements coupled to the actuating arm and the frame. Responsive to an activation that causes the one or more SMA elements undergo a dimensional transformation, the one or more SMA elements are configured to operate against the biasing member to bias the actuating arm in a second direction opposite the first direction relative to the frame.
F16K 31/02 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic
F16K 31/122 - Operating meansReleasing devices actuated by fluid the fluid acting on a piston
F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like
The present disclosure relates to the field of security systems and discloses a tamper detection device. The device (100) comprises at least one transducer (106,110), a power supply unit (114), a logical gate (112), a processing unit (104), and, a tamper tag 102). The transducer (106,110) generates a trigger signal upon detection of a tamper event. The logical gate (112) is operable in an open state or a closed state. The processing unit (104) generates a tamper detection signal for changing the state of the logical gate (112) upon receiving the trigger signal or upon detecting loss of power supply from the power supply unit (114). The change in state of logical gate (112) causes a tamper flag value stored in the tamper tag (102) to change, thereby indicating a tampered status to a reader scanning the tamper tag (102). The device (100) detects a tamper event even if the device (100) is not damaged/broken during tampering.
G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
G09F 3/03 - Forms or constructions of security seals
Examples of a wearable electronic system are described. The system comprises a sensor array and a data acquisition (DAQ) system comprising a processing module. The processing module receives a user identifier associated with the user, and sensor data from the sensor array. The processing module analyses the sensor data to determine a set of transient state sensor data from sensor data. The sensor data may be analysed based on the user identifier and a state of the sensor array. The processing module filters out the set of transient state sensor data from the plurality of sensor data to obtain steady state sensor data and causes to store the steady state sensor data.
G06F 1/16 - Constructional details or arrangements
A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
25.
ECO-FRIENDLY INK FORMULATION OF RESISTIVE INK FOR ROLLER BALL PEN
Provided herein is a resistive ink formulation comprising carbon black, an adhesive, glycerol and water. The ink formulation is aqueous and can be used in a conventional pen to create paper based flexible circuits enabling the user to freely make hand drawn resistors with resistances comparable to the conventional resistors in magnitude. The unique design of the formulation is that it can be designed for the desired output resistance and its application thereof. Also provided herein is a process for making the resistive ink formulation.
Examples of a wearable electronic system are described. The system comprises a sensor array and a data acquisition (DAQ) system. The DAQ system comprises a power source, a processing module comprising processors for performing a monitoring session, and a power management module. The power management module monitors a first function processor from the processors that is performing a first operation associated with the monitoring session and determines power source characteristics and operational characteristics of the sensor array and the DAQ system. The power management module analyses the power source characteristics and the operational characteristics of the sensor array and the DAQ system to determine a remaining number of monitoring session to be performed by the DAQ system. Further, the power management module causes to indicate the remaining number of monitoring session to a user.
A haptic tactile smart watch for the visually impaired is provided. The tactile smart watch comprises a watch case having a tactile digital interface. One or more tactile push buttons are configured on an outer circumference of the watch case. The one or more tactile push buttons activate one or more functions associated with the tactile smart watch. One or more touch sensitive indicators receive one or more touch inputs from a user input. Each of the one or more touch sensitive indicators generate one or more haptic feedback in response to the one or more touch inputs. A sensing module receives electrical signals corresponding to the identified specific actions from the one or more touch sensitive indicators, and senses one or more application parameters based on the received one or more electrical signals. The one or more application parameters are communicated, via haptic feedback, numerically to the user using touch sensitive indicators.
Present invention relates to a rapid soil testing device designed for measuring the soil physical and chemical properties. The device is designed to determine and monitor real time soil nutrient content. The device is based on the near infrared (NIR) spectroscopy. Near-IR (NIR) is a spectroscopic strategy which is based on molecular overtones and combination vibrations that originates from the fundamental vibrational bands which are generally found in the mid-IR (MIR) region. The results are displayed over an android smartphone using a developed mobile application and the results can be shared via WhatsApp or email in the form of a summary table. It also has the facility to keep the record of previous recommendations. It is a very low power device having battery backup up-to 60 min in a single charge and can also be powered using the 5 Volt DC supply or the smartphone through OTG cable.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
A sensor patch (100) for breast cancer screening is described. In an example, the sensor patch (100) includes a plurality of sensing elements (104) for acquisition of temperature response data from breasts of a subject. The sensor patch (100) further includes a 2-dimensional (2D) flexible substrate (102) that serves as a base for the plurality of sensing elements (104), where the 2D flexible substrate (102) includes a plurality of cuts (106, 108) to transform the sensor patch (100) into a desired breast geometry.
Techniques for determining presence of cancerous cells in breasts of a subject are described. In an example, transient temperature response data for the breasts is received. The transient temperature response data is then converted to steady state temperature response data. A set of features for the breasts are then extracted based on the steady state temperature response data. The set of features are then analyzed by at least one machine learning model, where the at least one machine learning model is trained based on data obtained from a plurality of subjects with confirmed presence of cancerous cells in the breasts. The presence of cancerous cells in the breasts is determined based on the analysis of the set of features by the at least one machine learning model.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
Examples of a data acquisition (DAQ) system for acquiring data from a sensor array are described. The sensor array includes a plurality of resistive sensors. The DAQ system comprises a multiplexing module coupled to the sensor array, and a control module coupled to the multiplexing module. The control module is configured to select a first sensor from the plurality of resistive sensors, cause the multiplexing module to read the first sensor for a first time period, wherein the plurality of resistive sensors other than the first sensor are non-operational during the first time period, and determine a first sensor output corresponding to the first sensor.
INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (INSTEM) (India)
Inventor
Jaswal, Akrit Pran
Bandyopadhyay, Amitabha
Vemula, Praveen Kumar
Mahato, Manohar
Kumar, Bhupendra
Abstract
The Invention relates to the clinical management of Osteoarthritis. Particularly, the Invention provides Disease modifying agents, Drug delivery system and method thereof for the management of Osteoarthritis.
The present invention relates to a targeted multimodal formulation comprising: mesoporous nanoparticle having a pH responsive coating; and an aptamer(s) conjugated to said mesoporous nanoparticle; the pH responsive coating is optionally carboxylated. The formulation may further comprise an anticancer agent.
The present invention presents a therapeutic combination Niclosamide with Doxorubicin for improved treatment of breast cancer. Niclosamide, an FDA approved anti-helminthic drug is repurposed as a Wnt signaling inhibitor for cancer therapy along with doxorubicin which is a first line treatment for breast cancer. The therapeutic combination of Niclosamide and doxorubicin caused synergistically enhanced death of breast cancer cells irrespective of their clinical subtype (viz. HR positive, HER2 positive and triple negative). Since single agent therapy proves to be inefficient in treating cancer and combination therapy is the need of the hour in clinics, such a combination therapy holds great potential to be an effective treatment option for breast cancer.
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
35.
A WEARABLE DEVICE FOR ASSISTING A VISUALLY IMPAIRED USER
A wearable device for assisting a visually impaired user is disclosed. The device includes a head-mounted image acquisition device to capture an image of a scene, a wearable computing device to track the visually impaired user's hand and finger's coordinates and to construct one or more virtual objects; a haptic glove which includes a controller to receive spatial information of one or more tracked coordinates when the real-time spatial position of the fingers of the visually impaired user overlaps with the one or more virtual objects, to generate a braille code on demand and activate the refreshable braille cell in order to display the character, commanded by the wearable computing device in tactile form, a tactile element to generate a haptic output for indicating reception of a produced detection signal, to provide a sensation of a presence of the virtual object in front of the visually impaired user.
SDD) in the buried oxide (BOX) under source and drain regions giving rise to potential well in the source and drain. These potential wells decrease the OFF current of the device.
The present invention provides for a process for producing a plurality of SUMOylation target-site modified AAV vectors, SUMOylation target-site modified AAV vectors, and application of the SUMOylation target-site modified AAV vectors in gene therapy. The present invention provides for manipulation of SUMOylation specific amino acids on AAV2 capsid protein, thereby regulating role of the same. Furthermore, the development of SUMOylation target modified AAV2 vectors presents an exciting opportunity for hepatic or ocular gene transfer with the safest AAV vector in human gene therapy applications. The plurality of SUMOylation target-site modified AAV vectors are not immunogenic in comparison to wildtype AAV2 vectors and possess significantly higher gene expression, with respect to wild type, thereby improving efficiency of hepatic and ocular gene transfer.
The present invention provides for a process for synthesising glycoengineered adeno-associated virus vectors. The process includes generating AAV vectors in presence of a group of glycosylation modulators. The process also includes predicting antigenicity of AAV2 capsid protein of the AAV vectors using B-cell and T-cell linear epitope mapping tools in order to refine epitopes of the AAV capsid protein. The process further includes targeting the refined epitopes for site-directed mutagenesis, while using a set of primers, by introducing or abolishing N- and O- glycosylation motifs in the AAV capsid to obtain the plurality of glycoengineered adeno-associated virus (AAV) vectors. The site-directed mutagenesis of target amino acids of the AAV capsid comprises NQ, QN, SA, AT, E/K/Q/RT and Y/S/TN. The glycoengineered adeno-associated virus vectors possess higher gene expression, with respect to wild type, after hepatic and ocular gene transfer.
The present invention provides a process for producing a plurality of Neddylation site modified AAV vectors. In one embodiment, the process comprises predicting a plurality of Neddylation sites on AAV VP1 capsid protein sequence based on relatively high confidence targets, wherein the AAV VP1 capsid protein sequence being set forth in Protein ID- YP_680426.1; and producing the plurality of Neddylation site modified AAV vectors based on predicted plurality of neddylation sites on AAV VP1 capsid protein sequence. The present invention for the first time highlights the role of Neddylation during AAV infection and its impact on generating novel AAV vectors with improved efficiency for ocular and hepatic gene therapy.
The present invention relates to a reusable polymer surface or media for writing. The media is in the form of a paper having a plurality of nano and micro- structured patterns, wherein an ink from a ball point pen, or from the inkjet can be 10 wiped off easily using a simple process of wiping off with a wet cloth. The present invention further provides a method of making or fabrication the reusable paper or writing surface or media. The process to enhance roughness of the surface of the polymer surface or media by forming hydrogel frames is also provided.
C08F 30/00 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
The present invention is in the field of bio-plastics. The invention particularly provides a process for preparation of agarose based bioplastic and an agarose based bioplastic thereof. The bio-plastic has good biocompatibility and mechanical strength. The bioplastic has uses in multiple fields including food/non-food applications, optical applications, drug delivery applications.
Nanobrushes, methods of forming nanobrushes, and methods of altering material with a nanobrush are disclosed herein. A nanobrush may include a substrate having a surface and a plurality of bristles deposited on at least one portion of the surface. The plurality of bristles may be arranged into a plurality of bunches. Each of the plurality of bunches may be spaced from an adjacent bunch at a bunch interval equal to or less than about 100 µm.
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
43.
POLYMERIC NANOCOMPOSITE FILMS WITH EMBEDDED CHANNELS
Method of forming micro channels in a polymeric nanocomposite film is provided. The method includes combining one or more monomers to form a mixture and adding a plurality of carbon fibers with metal nanoparticles dispersed therein to the mixture prior to or concurrently with formation of a polymer from the monomers. The method also includes adding at least one hydrophobic agent and at least one plasticizer to the polymer to form the polymeric nanocomposite film and forming a plurality of laser-etched micro channels in a surface of the polymeric nanocomposite film.
Embodiments of the present disclosure set forth methods for selecting a preferred data set from distributed databases including a first database having a first probability attribute and a second database having a second probability attribute. One example method may include receiving a first data set from the first database and a second data set from the second database. The first data set includes a first monotonic attribute. The second data set includes a second monotonic attribute. It may further include selecting a candidate data set from one of the first data set and the second data set based on a comparison of the first monotonic attribute and the second monotonic attribute and determining whether the selected candidate data set is the preferred data set.
Methods of forming a tunable focal length lens and an optical filter are disclosed. The tunable focal length lens may have varying focal lengths due to liquids within micro-channels which may cause varying cross-sectional areas of the micro- channels. The tunable focal length lens may have variable force. The tunable focal length lens may have a variable refractive index. The optical filter may have varying wavelengths due to dyes within the micro-channels. An apparatus incorporating an aspherical lens is also disclosed.
Technologies are generally described for a four-terminal, gate-controlled, thin-film thyristor device. The thyristor device may essentially be an n-type thin-film transistor (TFT) with an additional emitter terminal. The thyristor device may exhibit an S-shaped negative differential 5 resistance (NDR) characteristic resulting from conductance modulation. The conductance modulation may be caused by formation of a secondary channel for current flow due to an inherent structure of the device. The secondary channel may be formed in a semiconductor area within the device, the semiconductor area including a hole transporting organic semiconductor layer (HTL) and an electron transporting organic semiconductor layer (ETL). A gate terminal of 10 the thyristor device may further allow onset of NDR characteristics to be controlled and may allow the device to be switched off.
A master used for micro contact printing and methods of creating thereof are disclosed. The master may include a permeable membrane removed from a surface of a media plate having one or more microbial nutrients. The master may also include a plurality of microbes positioned upon at least a portion of the permeable membrane. The microbes may be grown in a vertical direction to form a patterned surface.
A focused ion beam system is provided. The focused ion beam system includes a plasma generation chamber configured to contain a source gas that is radiated with microwaves to produce plasma. The plasma generation chamber includes a plasma confinement device configured to confine the plasma in radial and axial directions within the plasma generation chamber and to form a plasma meniscus at an extraction end of the plasma generation chamber. The focused ion beam system also includes a beam extraction chamber configured to extract a focused ion beam from the confined plasma and to focus the extracted focused ion beam on a workpiece.
A novel Drosophila tumor model capable of screening target specific anti-cancer compounds. Tumorous growths in larval lymph organ and presumptive adult somatic epithelia are induced by aberration/mis-regulation of specific cellular pathways, caused by loss of a tumor suppressor gene, such as scribble. Tumorous growths are thereafter suppressed either by genetic manipulations or by exposure to anti-cancer compounds by blocking, down-regulating or compromising said aberrant signalling pathway. Methods for obtaining said novel Drosophila tumor model are also provided.
Methods of forming an organic thin film transistor are provided. The methods include providing a substrate and depositing and patterning a gate electrode on a first surface of the substrate. The methods include dispensing a first droplet of an insulating material on the gate electrode on the substrate and dispensing a second droplet of a semiconductor material on a first surface of the first droplet. The second droplet forms a hydrophobic structure having a central cavity. The methods also include dispensing a third droplet of a conductor material on a first surface of the second droplet such that the conductor material substantially fills the central cavity of the hydrophobic structure and forms a conductor material layer around the central cavity to define a source electrode and a drain electrode of the organic thin film transistor.
H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
51.
FABRICATION OF BINARY MASKS WITH ISOLATED FEATURES
An environmentally benign method for producing binary microfabrication masks is disclosed. An optical target may be provided that includes a water-soluble polymer material in contact with an ultraviolet radiation transmittable substrate. A laser may be focused on a primary mask to produce a mask image, the mask image thereafter being reduced by demagnification optics to provide a reduced image. The optical target may be exposed to the reduced image to create features of reduced size from the primary mask. The water-soluble polymer exposed to the ultraviolet radiation may be ablated from the optical target. The optical target may be subsequently metalized using a metal vapor to coat the remaining polymer material and exposed substrate. The metalized optical target may be contacted with an aqueous fluid to remove the metalized polymer material leaving the binary mask.
A thin film transistor (TFT) includes a hole transport layer having a first side and a second side and an electron transport layer having a first side and a second side. The first side of the electron transport layer is directly interfaced to the second side of the hole transport layer. The electron transport layer includes a material having greater ionization potential and greater electron affinity than the hole transport layer, thereby forming a hole barrier and an electron barrier at the junction between the electron transport layer and the hole transport layer. A channel in the TFT is created by current injected into the electron transport layer from a gate electrode rather than by an electrostatic field generated by voltage applied to the gate electrode. The accumulated charge density in the channel of the TFT can be significantly larger than what can be generated through field effect principle, therefore a much lower gate voltage is needed than in a conventional TFT.
Techniques described herein are generally related to metamaterial structures for Q-switching in laser systems. The various described techniques may be applied to methods, systems, devices or combinations thereof. Some described metamaterial structures may include a substrate and a first conductive layer disposed on a first surface of the substrate. A dielectric layer may be disposed on a first surface of the first conductive layer and a second conductive layer having a substantially symmetric geometric shape may be disposed on a first surface of the dielectric layer. The second conductive layer may cover a portion of the first surface of the dielectric layer.
H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
G02B 26/02 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light
54.
POLYMERIC NANOCOMPOSITES AND METHODS FOR THEIR PREPARATION AND USE
Methods of forming a polymeric nanocomposite are provided. The methods include combining one or more monomers to form a mixture and adding a plurality of carbon fibers to the mixture prior to or concurrently with formation of a polymer from the monomers. The methods can also include polymerizing the monomers to form the polymer and adding a hydrophobic agent and a plasticizer to the mixture to form the polymer nanocomposite.
B32B 5/28 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer impregnated with or embedded in a plastic substance
Embodiments of the present disclosure set forth methods for selecting a preferred data set. The methods include generating a joined relation based on a first relation having a first join attribute and a first existence probability attribute, and a second relation having a second join attribute compatible with the first join attribute and a second existence probability attribute, wherein the joined relation comprises a skyline probability attribute based at least in part on the product of a second value of the first existence probability attribute and a third value of the second existence probability attribute; and selecting, by one or more processors, the preferred data set from the joined relation based on a comparison of the first value of the skyline probability attribute and a predetermined threshold.
A system and method for producing binary dry process laser microfabrication masks is disclosed. A laser is focused on a first mask to produce a mask image, the mask image thereafter being reduced by demagnification optics to provide a reduced image. A target is exposed to the reduced image to create features of reduced size from the original mask. The target may be used to form a binary mask capable of withstanding laser radiation power necessary for direct target micromachining. A binary mask may be used to create other binary masks in an iterative process to provide binary masks with successively smaller features based on the image reduction due to the demagnification optics.
An apparatus for characterizing a focused charged beam is provided. The apparatus includes a plurality of parallel conducting channels and at least one current sensing unit configured to measure current across each of the plurality of parallel conducting channels.
A dual reporter plasmid construct for measuring Bone Morphogenetic Proteins (BMP) Signalling is provided. The dual reporter construct includes a BMP Responsive element of Sequence ID No 1 a minimal promoter gene cloned downstream of the BMP responsive element, a firefly luciferase reporter gene of Sequence ID No 3 cloned downstream of the BMP responsive element and the first minimal promoter gene, a constitutive promoter cloned downstream of the firefly luciferase reporter gene, a renilla luciferase reporter gene of Sequence ID No 7 cloned downstream of the constitutive promoter. The renilla luciferase reporter gene acts as an internal control that normalises any altered activity of the firefly luciferase gene in presence or absence of BMP or BMP agonist. The firefly luciferase reporter gene activity provides a quantitative measure of activity of the BMP responsive element.
Jawaharlal Nehru Centre for Advanced Scientific Research (India)
Inventor
Sharma, Ashutosh
Verma, Ankur
Kulkarni, Giridhar U.
Abstract
Methods and devices for preparing microscale polymer relief structures from a thin polymer layer on an absorbing substrate are described. The described methods are ultrafast (about 8 nanoseconds) and allow formation of patterned microstructures having complex morphologies and narrow line widths that are an order of magnitude smaller than the masks used in the methods.
B05D 3/06 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
B05D 3/00 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
A pressure-sensitive adhesive material including a visco-elastic layer and an elastic layer is provided. In some embodiments, a reusable pressure-sensitive adhesive material exhibiting high adhesive strength after repeated cycles of adhesion and detachment is provided. In some embodiments, methods of making a pressure sensitive adhesive material are provided.
Disclosed herein are biodegradable hydrogel scaffolds for use in tissue engineering. The hydrogel scaffolds are composed of synthetic terpolymers complexed with polyvinyl alcohol (PVA), which facilitate cell-sheet and tissue growth. In the presence of a monosaccharide, the PVA-hydrogel is dissolved and cell-sheets are released for harvesting. Further disclosed herein are methods for producing PVA hydrogels which support tissue growth. Tissue engineering applications and methods are also disclosed.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
62.
CRYOGELS OF PVA-BORONIC ACID CONTAINING CO-POLYMERS FOR CELL CULTURE
C08L 29/04 - Polyvinyl alcoholPartially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
C08F 230/06 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing boron
Provided herein are phenylboronate containing co-polymers (PCC), compositions containing PCC and polyvinyl alcohol (PVA), such compositions further including proteins, methods of making these compositions by water in oil polymerization, and methods of using the protein containing compositions for releasing proteins. Such phenylboronate containing co-polymers are of Formula I: where m, n, p, x, R1-R5, L, X1 and X2 are defined in the application.
C08F 230/06 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing boron
C08L 29/04 - Polyvinyl alcoholPartially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
A process of preparing a zinc chalcogenide includes providing a solution of 8-hydroxyquinoline; a zinc precursor; and a reaction solvent; isolating a precipitate from the solution; and calcining the precipitate to form the zinc chalcogenide. Additionally, a polymer composite may include a polymer, bis(8-hydroxyquinolinato)zinc, and elemental sulfur or bis(8-hydroxyquinolinato) z M, wherein M is a metal ion and the value of z is equivalent to the oxidation state of the metal ion.
A process of preparing a doped aluminum oxide, includes providing a solution comprising 8-hydroxyquinoline; an aluminum precursor; a dopant precursor, and a reaction solvent; isolating a precipitate from the solution; and calcining the precipitate to form the doped aluminum oxide. Compositions may be prepared which include tris (8- hydroxyquinolinato) aluminum and (8-hydroxyquinolinato) z M, wherein M is a metal ion and the value of z is equivalent to the oxidation state of the metal ion.
Drive signals for a display device may be generated using Separable Nonnegative Matrix Series Representation (SNMSR) of source image data and applying a non- negative matrix factorization (NNMF) process to source image data to generate approximation image data (Ii), partial sum image data (Pi) and residue image data (Ji). Iteratively, NNMF may be applied to Ji such that subsequent Ii and Ji may be generated, where each Ii can be associated with a corresponding sub-frame image. At each iteration, the Ii may be sent to the display buffer for selective activation of multiple row and column drivers during a single sub-frame interval. At each iteration, a determination may be made if a predetermined criterion is satisfied. The iterations may be terminated and the series truncated when the predetermined criterion is satisfied. Integration of the sub-frame images displayed over a complete frame interval by human eye effectively corresponds to the source image.
Systems and methods for imaging characteristics of a sample and for identifying regions of damage in the sample are generally described. Some example systems and methods for non-destructive evaluation of regions of material may operate in a direct current (DC) mode in which the system directly images regions of material where weak structural damage has occurred by imaging a self magnetic field generated by a DC electric current coupled through the material. Some example systems may operate in an alternating current (AC) mode to image regions of material where damage has occurred by generating a time varying magnetic field due to AC excitation coils inducing eddy currents in the sample, and imaging a magnetic field generated by the eddy currents around the regions of damage. The systems may use magneto-optical imaging techniques (MOI) to measure and map the magnetic field and channels of current flow in the material, for example.
G01N 27/82 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables for investigating the presence of flaws
G01N 21/88 - Investigating the presence of flaws, defects or contamination
G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday
68.
CARBON NANOFIBER/CARBON NANOCOIL - COATED SUBSTRATE AND NANOCOMPOSITES
A composition includes a substrate and a carbon filament where the carbon filament has a first end in contact with the substrate and a second end that is distal to the substrate. The carbon filament may be a carbon nanofiber or carbon nanocoil. The substrate may be a glass fiber and the carbon filament may be radially attached to the glass fiber.
B32B 27/02 - Layered products essentially comprising synthetic resin in the form of fibres or filaments
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
Hydroxyapatite-polymer nanocomposites, which are nanoparticles/microparticles, methods for making them, and articles made from them are disclosed. These methods are capable of preparing nanocomposites exhibiting more homogeneous dispersion of nanoparticles than is seen using previous methods. Such nanocomposites and articles are useful for a wide variety of applications, such as biological, medical, biochemical, biosensor, fuel cell, and aerospace applications.
C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
B32B 3/00 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form
A61L 27/12 - Phosphorus-containing materials, e.g. apatite
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
Techniques described herein generally relate to methods of manufacturing devices and systems including devices including a substrate with a surface, a conductive polymer film arranged on the surface of the substrate, wherein the conductive polymer film has one or more temperature reactive characteristics, and a pair of electrodes coupled to the polymer film, wherein the pair of electrodes are configured to communicate electrical signals to the conductive polymer film effective to measure the one or more temperature reactive characteristics. The conductive polymer film may be arranged on the surface of the substrate such that a thickness and dopant ratio of the conductive polymer film on the substrate is configurable.
A method, system and device are described for generating high-resolution flow-field data from sparse measurement data by interpolating from a reference database of pre-computed, highly-resolved fluid dynamic simulation results, to generate a highly-resolved set of flow field data which correspond to the sparse measurements. In one embodiment, the method, system and device use Principal Component Analysis techniques to interpolate the multidimensional fluid flow data. Applications of the invention are, amongst others, in the field of biomedical diagnosis involving fluid dynamic modeling of biological fluid systems such as blood flow in an artery.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
72.
A METHOD AND APPARATUS FOR THE FORMATION OF PATTERNS ON SURFACES AND AN ASSEMBLY AND ALIGNMENT OF THE STRUCTURE THEREOF
The formation of self-assembled patterns and their modulation in a visco-elastic surface layer via substantially elastic deformations induced by displacement of a stamp in contact with the surface layer are disclosed. Methods and apparatus of the present invention may be employed to form arrays of micrometer and sub-micrometer channels, wells and pillars and other complex structures by using displacements of the single stamp. The elastic structures thus formed can be altered in-situ and also preserved, if desired.
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
H01L 21/00 - Processes or apparatus specially adapted for the manufacture or treatment of semiconductor or solid-state devices, or of parts thereof
patents
