Abstract

In various embodiments, the present invention provides a method for forming a porous pellet, a porous pellet obtained or obtainable according to such methods, and uses of such porous pellets The method comprising steps of forming a slurry from slurry components including a particulate inorganic material, a first solvent, and polymeric binder; immersing droplets of the slurry in a second solvent, the second solvent being selected to be miscible with the first solvent and immiscible with the polymeric binder, to form a precursor pellet; and performing a heat treatment on the precursor pellet to thereby form the porous pellet.

IPC Classes  ?

• B01J 23/75 - Cobalt
• B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• B01J 35/51 - Spheres
• B01J 37/00 - Processes, in general, for preparing catalystsProcesses, in general, for activation of catalysts
• C04B 38/00 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof

Abstract

The invention relates to invariant natural killer T (iNKT) cells, and particularly, although not exclusively, to iNKT cell engagers or fusion proteins, which specifically bind to iNKT cells. The invention extends to nucleic acids encoding such iNKT cell engagers, as well as novel pharmaceutical compositions comprising these engagers, and to their use in therapy, as well as therapies and methods for treating, preventing, or ameliorating cancer.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 40/15 - Natural-killer [NK] cellsNatural-killer T [NKT] cells
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/42 - Cancer antigens
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

Provided here in is a system for clinical assessment of a user, the system comprising one or more processors. The one or more processors are configured to obtain movement data of a user, the movement data recorded during the user's behaviour. The one or more processors are further configured to determine, based on processing the recorded movement data using a first machine learning model, one or more movement features. The one or more movement features comprise a sequence of activity classes and a duration of time the user spends in each of the activity classes. Each activity class represents one or more activities performed by the user during the user's behaviour. The one or more processors are further configured to determine, using a second machine learning model, a metric indicative of a clinical assessment of the user. The second machine learning model takes as inputs at least the one or more movement features.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

The invention provides a nucleic acid construct that is useful in directing RNA mediated gene regulation or RNA mediated gene editing. The invention further provides cells comprising the nucleic acid construct, and methods of using the same.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 9/22 - Ribonucleases
• C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts

Abstract

The invention relates to a composition for preparing a 3D scaffold for culturing cells and tissue, such as human cells and tissue. In particular embodiments, the present invention relates to a composition comprising a biocompatible polymer suitable for the preparation of a hydrogel, and a modified extracellular matrix (ECM) protein that is unreactive towards the biocompatible polymer, such that, after preparation of a hydrogel, the modified ECM protein is not covalently bound to the hydrogel. Compositions of the invention are suitable for use in 3D bioprinting, tissue engineering, drug screening, disease modelling and methods of treatment such as tissue regeneration.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells

Abstract

Provided is lipid nanoparticle functionalised with a glycopolymer. The glycopolymer comprises at least four carbohydrate units, wherein each carbohydrate unit is independently selected from a monosaccharide, a disaccharide and an oligosaccharide. The lipid nanoparticle can be used for inducing an immune response in a subject.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present invention relates to the treatment of telangiectasia, particularly telangiectasia associated with hereditary haemorrhagic telangiectasia (HHT). The present invention provides treatments for telangiectasia associated with HHT, and HHT-induced anaemia and/or haemorrhage. Methods of identifying patients suitable for such treatment are also provided.

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 7/04 - AntihaemorrhagicsProcoagulantsHaemostatic agentsAntifibrinolytic agents
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The invention provides methods of co-culturing organisms, and in particular methods of co-culturing a methanotroph and a methylotroph in the presence of urea which stimulates methanol production by methanotroph Methylosinus trichosporium which is then used by methylotroph yeast Komagataella phaffii to produce target protein. Also described are methods for the production of target products from said co-culture.

IPC Classes  ?

• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
• C12N 1/16 - YeastsCulture media therefor
• C12N 1/20 - BacteriaCulture media therefor
• C12P 7/04 - Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
• C12P 39/00 - Processes involving microorganisms of different genera in the same process, simultaneously

Abstract

A method of fitting spectrum data to a model of biological substance data is disclosed. The method comprises receiving spectrum data, receiving fitting data for each of a plurality of biological substances, wherein fitting data comprises, for each of the plurality of biological substances: a number of reference multiplets for that biological substance, and for each reference multiplet, the position of the centre of that reference multiplet, the number of peaks for that reference multiplet, the relative amplitude of each peak, and the width of each peak. The method further comprises determining a fitting order of the reference multiplets, wherein the position of each reference multiplet in the fitting order is based on the number of possible overlaps with other reference multiplets comprised in the fitting data, starting with the fewest overlaps and ending with the most.

IPC Classes  ?

• G01R 33/46 - NMR spectroscopy
• G01R 33/465 - NMR spectroscopy applied to biological material, e.g. in vitro testing

Abstract

A prosthetic joint comprising: a proximal part having a proximal side, a distal side opposed to the proximal side, and a mounting point on the proximal side configured to connect to a proximal prosthetic limb part, a distal part configured to connect to a distal prosthetic limb part, a polycentric linkage mechanism connected to the proximal and distal parts and arranged to rotate the distal part from an extended position, where the distal part is disposed on the distal side of the proximal part, to a flexed position, where at least a portion of the distal part is disposed on the proximal side of the proximal part. The distal part is arranged to rotate relative to the proximal part about an instantaneous axis of rotation, the axis of rotation defining a medial-lateral axis of the proximal part. The linkage mechanism comprises a first linkage and a further pair of linkages, each of which are pivotally connected to the proximal and distal parts via respective connection points. The position of the instantaneous axis of rotation is determined by the location of the connection points of the first linkage and the further pair of linkages. The connection points of the first linkage are spaced from a mid-plane of the proximal part by a smaller distance along the medial-lateral axis than the connection points of the pair of linkages. The distal part is spaced from the proximal part in the direction of flexion as the distal part is rotated between the extended position and the flexed position. In the extended position, the connection points of the first linkage are spaced from the mounting point by a smaller distance in the direction of flexion than the connection points of the pair of linkages.

IPC Classes  ?

• A61F 2/64 - Knee joints
• A61F 2/58 - ElbowsWrists
• A61F 2/68 - Operating or control means

Abstract

The present disclosure relates to a computer-implemented method, comprising: receiving sensor data from one or more myography sensors of a wearable sensor apparatus, wherein the one or more myography sensors are configured to monitor muscle activation of a subject; determining, based on the sensor data, whether a first muscle of the subject has been selectively activated; and providing biofeedback based on the determination of whether the first muscle has been selectively activated.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/389 - Electromyography [EMG]
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Protein and RNA-based condensates are emerging as an alternative to classical membrane-bound organelles for the task of compartmentalizing molecules and biochemical reactions. We describe methods for making pure RNA condensates emerging from star-shaped RNA motifs (nanostars) that fold from a single molecule of RNA and interact via kissing loop domains. Through computational design of the nanostar sequences, we demonstrate orthogonal (distinct and immiscible) condensates, which can be individually tracked via fluorogenic aptamers. We also show that aptamers make it possible to recruit peptides and proteins to the condensates with high specificity. We show that nanostars form condensates when assembled from purified and annealed RNA, and when they are being transcribed from synthetic templates at constant physiological temperature. Such orthogonal RNA condensates can be modularly customized and offer a route toward creating systems of functional artificial organelles.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

The present invention is directed to nanoparticle compositions obtainable from the polymerisation of oligolactoglycolic acid dimethacrylates (OLGADMAs), methods for preparing said OLGADMAs, methods for preparing said nanoparticle compositions, and uses thereof. In one aspect the present invention provides a nanoparticle composition obtainable from precipitation polymerisation of one or more oligomers of formula (I), as defined herein.

IPC Classes  ?

• C08G 63/06 - Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxy carboxylic acids
• C08G 63/08 - Lactones or lactides
• C08G 63/91 - Polymers modified by chemical after-treatment

Abstract

There is provided a method for monitoring of one or more process parameters of a chemical process to convert one or more input substances to one or more output substances at different solvent ratios, comprising (a) providing a plurality of input streams, each comprising a solvent or solvent mixture and one or more input substances for the chemical process, wherein at least two of the input streams comprise a distinct solvent or solvent mixture; (b) delivering one or more of the input streams to a flow reactor; (c) varying the ratio of solvents within the flow reactor by changing relative flow rates of the input streams to the flow reactor; and (d) monitoring one or more process parameters at different solvent ratios. There is provided a system for carrying out the method. There is also provided a method of training a machine learning model to predict one or more process parameters of the chemical process, and a method of designing and performing the chemical process.

IPC Classes  ?

• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus

Abstract

Described herein are silica supplementary cementitious materials, composite cements and processes for their preparation. Also described herein are processes for preparing a composite cement comprising cement (e.g. Portland cement), a silica material (e.g. as an SCM), and optionally a carbonate material (e.g. as a filler), wherein said processes include the preparation of the silica material.

IPC Classes  ?

• C04B 14/06 - QuartzSand
• C01B 33/193 - Preparation of finely divided silica neither in sol nor in gel formAfter-treatment thereof by acidic treatment of silicates of aqueous solutions of silicates
• C01F 5/24 - Magnesium carbonates
• C04B 14/26 - Carbonates
• C04B 28/04 - Portland cements
• C04B 111/00 - Function, property or use of the mortars, concrete or artificial stone

Abstract

The invention relates to a compound of formula I, wherein: A, B, R1, R2, L1, m and n are as defined in the specification, or a salt or solvate thereof, which compounds are useful for forming Raman-tagged bioconjugates with a biomarker and/or biomolecule and are detectable with Raman spectroscopy

IPC Classes  ?

• C07C 309/58 - Carboxylic acid groups or esters thereof
• A61K 31/185 - AcidsAnhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
• G01N 21/65 - Raman scattering
• G01N 33/483 - Physical analysis of biological material
• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper

Abstract

The invention provides an apparatus for fluidic exfoliation of a layered material comprising: a housing of circular cross-section defined by a housing wall; a hollow rotor of circular cross-section having a first end and a second end and a wall positioned therebetween arranged concentrically within the housing, wherein the wall of the hollow rotor defines an inner chamber and the space in between the wall of the hollow rotor and the housing wall defines an outer chamber, and wherein a fluid flow path is provided between the inner chamber and the outer chamber; a fluid inlet in fluid communication with the inner chamber or the outer chamber; and a fluid outlet in fluid communication with the other of the inner chamber or the outer chamber; wherein the outer chamber has a width such that on passage of a fluid comprising the layered material from the inlet to the outlet through the outer chamber, a shear rate sufficient to exfoliate the layered material may be applied to the fluid comprising the layered material in the outer chamber by rotation of the hollow rotor.

IPC Classes  ?

• C01B 32/19 - Preparation by exfoliation
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• B01J 19/18 - Stationary reactors having moving elements inside

Abstract

The present disclosure relates to systems and methods of detecting nucleic acids using a combination of a Cas-based reaction with catalytic nanoparticles. Provided is a nucleic acid detection system for detecting one or more target nucleic acids, the system comprising a CRISPR effector protein; one or more guide RNAs (gRNA), each of which is specific for the one or more target nucleic acids; and a reporter RNA molecule; and a catalytic nanoparticle. Also provided is a reporter RNA molecule for a CRISPR detection assay. The disclosure also relates to uses, methods and kits for detecting one or more target nucleic acids. The uses, methods and kits extend to diagnosing a disease in a patient based on the presence of a nucleic acid of interest.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present application relates to a polymer (such as a polymer of intrinsic microporosity). This comprises a polymeric backbone comprising contorted aromatic moieties and at least one side group as defined herein.

IPC Classes  ?

• C08G 10/00 - Condensation polymers of aldehydes or ketones with aromatic hydrocarbons or halogenated aromatic hydrocarbons only
• C08G 10/02 - Condensation polymers of aldehydes or ketones with aromatic hydrocarbons or halogenated aromatic hydrocarbons only of aldehydes
• C08G 10/04 - Chemically modified polycondensates
• C08G 65/40 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives derived from phenols from phenols and other compounds
• C08G 65/48 - Polymers modified by chemical after-treatment
• B01D 71/00 - Semi-permeable membranes for separation processes or apparatus characterised by the materialManufacturing processes specially adapted therefor
• C08G 61/00 - Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule

Abstract

The present invention relates to peptides, and particularly, although not exclusively, to peptides isolated from the human gut microbiome which impact the gut-brain-axis in a subject. The invention extends to the use of these peptides in therapy, as well as novel compositions, therapies, and methods for treating, preventing, or ameliorating diseases caused by, or associated with, the gut-brain-axis.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

The present disclosure provides a lyophilized composition for use in a colorimetric nucleic acid amplification reaction. Also provided are processes for producing a lyophilized composition and methods for determining the presence of a target nucleic acid in a test sample or diagnosing or treating infection by a pathogen in a subject.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

The present invention relates to RNA molecules, and particularly, although not exclusively, to unlocked nucleotides (UNAs) and unlocked nucleic acid (UNA)-RNA molecules per se, to methods for preparing UNA-RNA molecules, and to methods for translating UNA-RNA molecules into protein. The invention extends to improved methods for forming UNA-RNA by in vitro transcription, and to the resultant UNA-RNA molecules. Furthermore, the invention relates to novel methods for enhancing the expression and/or translation of RNA, i.e. protein expression, and to methods for improving the stability of an RNA molecule. The invention also involves reducing the activation of innate sensing, interferon generation and/or degradation of an RNA molecule in a host. The invention also incorporates the use of the UNA-RNA molecules in vaccines and other therapeutic pharmaceutical compositions, and their use in immunisation and therapy, such as RNAi, gene therapy, gene editing and protein replacement. Furthermore, the invention relates to novel methods for enhancing translation of RNA, i.e. protein expression.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/67 - General methods for enhancing the expression

Abstract

A method of determining an arrangement for objects comprises obtaining first data representing a first arrangement of first objects in a scene; inputting the obtained first data into a trained machine learning model to determine a first cost value for the first arrangement. The first cost value is indicative of an extent to which the first arrangement differs from an optimum arrangement of the first objects according to a cost function that the machine learning model has been trained to provide. The method comprises determining a second arrangement for the first objects based on the first cost value.

IPC Classes  ?

• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06T 1/00 - General purpose image data processing
• G06V 20/70 - Labelling scene content, e.g. deriving syntactic or semantic representations

Abstract

Disclosed are methods of achieving viral resistance in animals and modified protein sequences which exhibit reduced polymerase activity.

IPC Classes  ?

• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A01K 67/0275 - Genetically modified vertebrates, e.g. transgenic
• C07K 14/465 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from birds

Abstract

The present invention relates to the metal enhanced fluorescence and chips designed to improve the usefulness of current chips. Specifically, the chips of the present invention are able to enhance fluorescence from a range of spectral regions.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence

Abstract

A computer implemented method for updating a scene representation model is disclosed. The method comprises obtaining a scene representation model representing a scene having one or more objects, the scene representation model being configured to predict a value of a physical property of one or more of the objects; obtaining a value of the physical property of at least one of the objects, the obtained value being derived from a physical contact of a robot with the at least one object; and updating the scene representation model based on the obtained value. An apparatus is also disclosed.

IPC Classes  ?

• G05D 1/246 - Arrangements for determining position or orientation using environment maps, e.g. simultaneous localisation and mapping [SLAM]
• G05D 105/80 - Specific applications of the controlled vehicles for information gathering, e.g. for academic research
• G06T 7/50 - Depth or shape recovery
• G06T 7/70 - Determining position or orientation of objects or cameras
• G06V 20/70 - Labelling scene content, e.g. deriving syntactic or semantic representations

Abstract

The invention relates to protein signatures, and particularly, although not exclusively, to protein signatures detected in methods and kits for distinguishing between and diagnosing a bacterial and/or viral infection. The invention also relates to the use of a protein signature as a diagnostic or prognostic biomarker for a bacterial and/or viral infection.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C07K 14/495 - Transforming growth factor [TGF]
• C07K 14/52 - CytokinesLymphokinesInterferons
• C07K 14/525 - Tumour necrosis factor [TNF]
• C07K 14/53 - Colony-stimulating factor [CSF]
• C07K 14/535 - Granulocyte CSFGranulocyte-macrophage CSF
• C07K 14/54 - Interleukins [IL]
• C07K 14/545 - IL-1
• C07K 14/55 - IL-2
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants

Abstract

The present disclosure relates to a device for detecting mechanical force at multiple regions of a surface, the device comprising: a plurality of sensor bodies, wherein each of the plurality of sensor bodies comprises: a deformable material; and a piezoelectric sensor configured to detect a displacement of a region of the surface upon deformation of the deformable material by the region of the surface; wherein the piezoelectric sensor of a first one of the plurality of sensor bodies is isolated from the piezoelectric sensor of a second one of the plurality of sensor bodies such that deformation of the piezoelectric sensor of the first one of the plurality of sensor bodies does not cause deformation of the piezoelectric sensor of the second one of the plurality of sensor bodies.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G01L 1/16 - Measuring force or stress, in general using properties of piezoelectric devices
• H10N 30/30 - Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors

Abstract

A wireless power transfer system comprising: a transmitter unit, the transmitter unit comprising a first transceiver coupled to a first inductive coil and configured to drive the first inductive coil; and a receiver unit, the receiver unit comprising a second transceiver coupled to a second inductive coil for inductive coupling with the first inductive coil; wherein the receiver unit further comprises an injection-locked oscillator coupled to the second transceiver for defining an oscillation frequency of the second transceiver, the injection-locked oscillator configured to synchronize with a driving frequency of the transmitter unit.

IPC Classes  ?

• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
• H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
• H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power

Abstract

in vivoin vitroin vitro.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

There is provided apparatuses and methods for measuring at least one thermal property of a body. The methods involve causing a symmetrical thermal boundary condition across the body such that measurements taken are not affected by the structure of the body being measured.

IPC Classes  ?

• G01N 25/20 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity

Abstract

Apparatus for discriminating between tumour tissue and non-tumorous tissue, the apparatus comprising: a handheld bioimpedance probe having a plurality of electrodes mounted thereon, wherein the plurality of electrodes are greater than four in number; a current source configured to generate a stimulation current; a voltage sensor; one or more multiplexers coupled between the current source, the voltage sensor and the electrodes and configured to changeably select a subset of four electrodes from the plurality of electrodes, and, for each selected subset of four electrodes, to switch between a plurality of switching configurations, wherein, in each switching configuration, a first pair of the selected subset of four electrodes are connected to the current source, and a second pair of the selected subset of four electrodes are connected to the voltage sensor, the electrodes that constitute the first pair and the electrodes that constitute the second pair changing from one switching configuration to the next; and processor-controlled circuitry configured to: control the selection of the subset of four electrodes by the one or more multiplexers; control the switching configuration of the one or more multiplexers with respect to the selected subset of four electrodes; control the generation of the stimulation current by the current source and the application of the stimulation current to the first pair of electrodes of each switching configuration, such that, in use, the stimulation current flows through tissue between the first pair of electrodes; control the measurement, by the voltage sensor, of the voltage between the second pair of electrodes of each switching configuration, across the tissue; determine, based on the applied current and the measured voltages for each switching configuration, a measure of relative impedance of the tissue for each switching configuration; and supply such impedance measurements as output data to a data analyser to enable real-time discrimination of the tissue to be performed, based on the impedance measurements.

IPC Classes  ?

• A61B 5/0536 - Impedance imaging, e.g. by tomography
• A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
• A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to a process for the separation of enantiomeric crystals by enantioselective crystal floatation and to a process in which preferential crystallization is combined with enantioselective crystal floatation.

IPC Classes  ?

• B01D 9/00 - Crystallisation
• B03D 1/02 - Froth-flotation processes

Abstract

The present invention relates to methods for obtaining a metabolic signature in a subject, said method being applicable for a range of purposes, including diagnosing disease, monitoring disease progression and/or determining a suitable treatment plan.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Modified cells suitable for the production of ergot alkaloids include engineered recombinant cells having one or more genes that code for one or more enzymes in the biosynthetic pathway from tryptophan to D-lysergic acid (DLA). Methods of culturing the engineered recombinant cells can be used for the production of DLA and other ergot alkaloids.

IPC Classes  ?

• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/08 - Oxidoreductases (1.), e.g. luciferase acting on hydrogen peroxide as acceptor (1.11)
• C12N 9/10 - Transferases (2.)
• C12P 17/18 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin

Abstract

A magnetic medium is described which includes a thin film magnet structure formed of a ferromagnetic alloy or compound. The thin film magnet structure includes one or more ferromagnetic domains and is coupled to one or more optical structures. Each of the one or more ferromagnetic domains have a magnetization that is switchable between two or more states. Each of the one or more optical structures is configured to increase absorbance of light at a target wavelength in the thin film magnet structure, such that in response to illumination of a ferromagnetic domain with continuous-wave light including the target wavelength, that ferromagnetic domain undergoes all-optical magnetic switching.

IPC Classes  ?

• G11B 11/105 - Recording on, or reproducing from, the same record carrier wherein for these two operations the methods or means are covered by different main groups of groups or by different subgroups of group Record carriers therefor using recording by magnetisation or demagnetisation using a beam of light or a magnetic field for recording and a beam of light for reproducing, e.g. light-induced thermomagnetic recording or Kerr effect reproducing

Abstract

The present application relates to an electrode comprising a redox-active material and a low- dimensional carbon material. At least around 70% of the surface of the electrode comprises at least one layer comprising the low-dimensional carbon material. The electrode comprises at most around 45 wt% low-dimensional carbon material, based on the total weights of low-dimensional carbon material and redox-active material in the electrode.

IPC Classes  ?

• H01M 4/04 - Processes of manufacture in general
• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulatorsProcesses of manufacture thereof
• H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/139 - Processes of manufacture
• H01M 4/1391 - Processes of manufacture of electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/48 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers

Abstract

A method of determining the geometry of interaction between a protein or nucleic acid and one or more chemical entities, the method comprising the steps of: (a) providing an experimentally obtained multi-dimensional spectrum for a sample comprising the protein or nucleic acid and the one or more chemical entities; (b) providing two or more structural hypotheses; (c) obtaining a computationally generated multi-dimensional spectrum of the same type as the experimentally obtained multi-dimensional spectrum for each of the two or more structural hypotheses; (d) determining which of the computationally generated multi-dimensional spectra best fits the experimentally obtained multi-dimensional spectrum; and (e) based on step (d), identifying the geometry of interaction between the protein or nucleic acid and one or more chemical entities.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR

Abstract

A method of determining an effect of a modified peptide is disclosed. The method comprises comparing a behavioural phenotype of an organism, the organism having ingested a cell culture, wherein cells in the cell culture are configured to produce a modified peptide, with a reference behavioural phenotype of organisms of the same species, and determining whether the peptide has an effect based on the difference between the behavioural phenotype and the reference behavioural phenotype.

IPC Classes  ?

• G06V 10/771 - Feature selection, e.g. selecting representative features from a multi-dimensional feature space
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

The present invention relates to RNA molecules, and particularly, although not exclusively, to methods for preparing RNA molecules, and to methods for translating RNA molecules into protein. The invention extends to improved methods for forming RNA by in vitro transcription, and to the resultant RNA molecules. Furthermore, the invention relates to novel methods for enhancing the expression and/or translation of RNA, i.e. protein expression, and to methods for improving the stability of an RNA molecule. The invention also involves reducing the activation of innate sensing, interferon generation and/or degradation of an RNA molecule in a host. The invention also incorporates the use of the RNA molecules in vaccines and other therapeutic pharmaceutical compositions, and their use in immunisation and therapy, such as RNAi, gene therapy, gene editing and protein replacement. In particular, the invention relates to locked nucleotides and locked nucleic acid (LNA)-RNA molecules, and the use or incorporation of such locked nucleotides and LNA-RNA molecules in any of the above applications.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

An aspect of the disclosure provides a bone implant system for stimulating growth in bone tissue cells of a human or animal patient, the system comprising: a bone implant (530); and an apparatus configured to be carried by the bone implant, the apparatus comprising: an energy provider (512), comprising an electromagnetic coupler configured to obtain electromagnetic energy via an electromagnetic field from an energy source disposed outside a body of the patient, wherein the electromagnetic coupler is carried by an external surface of the bone implant system; and a stimulator (517) configured to provide, based on energy from the energy provider, at least one of electrical or mechanical stimulus to a bone into which the bone implant is implanted.

IPC Classes  ?

• A61F 2/28 - Bones
• A61F 2/48 - Operating or control means, e.g. from outside the body, control of sphincters

Abstract

The present invention relates to methods for the synthesis of peptides and related compounds supported on a solid polymeric resin. The inventive method provides synthetic schemes that permit the coupling of two or more peptide fragments attached to the same polymeric support, in a fashion that allows access to previously unobtainable structures, and provides a more convenient and higher-yielding approach to known peptides, including those of commercial significance.

IPC Classes  ?

• C07K 1/04 - General processes for the preparation of peptides on carriers
• C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides

Abstract

An aspect of the disclosure provides a surgical robot (10) for deployment in an internal body lumen of a human or animal subject, the robot comprising: an inflatable scaffold (12) having a collapsed state for delivery to a target site in the lumen and an inflated state in which the scaffold defines an open cavity (18), a manipulator (14) movable in the cavity for manipulating a medical device; and a soft actuator (16) operable by fluid pressure to move the manipulator (14) by applying force between the scaffold (12) and the manipulator, wherein the scaffold (12) is arranged around the soft actuator (16) to provide protection between the soft actuator and the body lumen.

IPC Classes  ?

• A61B 34/30 - Surgical robots
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The present invention relates to bioproduction of dyes and dyed biomaterials, and in particular relates to cells and methods for producing indigoidine. The invention also provides a dyed cellulose material and methods for producing the same.

IPC Classes  ?

• C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/88 - Lyases (4.)
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12P 17/16 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing two or more hetero rings
• C12R 1/645 - Fungi

Abstract

The present invention provides a method for predicting an outcome of pregnancy, particular for predicting the likelihood of ectopic pregnancy (EP) or viable intrauterine pregnancy (VIUP), and methods for determining appropriate protocols for subjects with a pregnancy of unknown location (PUL) based on such an outcome, comprising determining the expression level of one or more specific miRNA molecules that are differentially expressed in scenarios of EP or VIUP, extracted from a biological sample obtained from said subject and comparing to a control value. The present invention also provides biochips and kits for use in carrying out the methods of the invention.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

A carbon-capture device and related processes are disclosed. The devices include substrate surfaces having a textured surfaces and a liquid sorbent contacting the texture surface in either a Cassie-Baxter state, in the case of a texture omniphobic surface or a plurality of re-entrant features or a Wenzel state, in the case of a textured omniphilic surface. The liquid sorbent reversibly captures a chemical species, which can usefully be carbon dioxide. This reversible capture can be exploited to capture and sequester carbon or other chemical species of interest.

IPC Classes  ?

• B32B 15/08 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
• B32B 27/20 - Layered products essentially comprising synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
• B32B 27/32 - Layered products essentially comprising synthetic resin comprising polyolefins

Abstract

The present invention provides compositions and methods for enhancing fluorescence from emitters that emit in the NIR-II and NIR-III. The compositions have particular use in both in vitro diagnostics, and in the live imaging of tissue during surgery, for example during removal of a tumour.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo

Abstract

Disclosed herein is a compound according to formula Ia: Also disclosed herein are a pharmaceutical composition comprising the compound as aforementioned, use of the compound as aforementioned, a method of treating one or both of a microbial and a fungal infection comprising the step of administering a pharmaceutically effective amount of the compound as aforementioned or the pharmaceutical composition as aforementioned, and an antimicrobial and/or antifungal detergent composition comprising the compound as aforementioned, and a surfactant.

IPC Classes  ?

• C08G 73/06 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromoleculePolyhydrazidesPolyamide acids or similar polyimide precursors
• C08L 79/04 - Polycondensates having nitrogen-containing heterocyclic rings in the main chainPolyhydrazidesPolyamide acids or similar polyimide precursors
• A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
• A61K 8/40 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
• A61P 31/04 - Antibacterial agents
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• A61Q 5/02 - Preparations for cleaning the hair
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
• A01P 3/00 - Fungicides
• A01N 43/54 - 1,3-DiazinesHydrogenated 1,3-diazines

Abstract

A computer-implemented method of controlling operation of a water distribution network, WDN, comprising obtaining data pertaining to parameters of the WDN; comparing the data with a hydraulic model of the WDN; determining an error value based on the comparing the data with the hydraulic model; determining that the error value is below a threshold; using the data to obtain an updated hydraulic model; and using the updated hydraulic model to control one or more elements of the WDN.

IPC Classes  ?

• G05B 17/00 - Systems involving the use of models or simulators of said systems
• G06Q 50/06 - Energy or water supply

Abstract

The disclosure related to an interferometer comprising a first mirror array comprising a first mirror and a second mirror; and an adjustable beam-steering device. The beam steering device configured to receive a first beam and a second beam, split from a source beam; steer the first beam onto the first mirror of the first mirror array; and steer the second beam onto the second mirror of the first mirror array. The first mirror array is configured to reflect, by the first mirror, the first beam, and reflect, by the second mirror, the second beam, to combine the first beam and the second beam to generate an interference pattern.

IPC Classes  ?

• G01B 9/02001 - Interferometers characterised by controlling or generating intrinsic radiation properties
• G01B 9/02015 - Interferometers characterised by the beam path configuration
• G01B 11/25 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures by projecting a pattern, e.g. moiré fringes, on the object
• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light

Abstract

Small molecules have been the preferred modality for drug development and therapeutic interventions. This molecular format presents a number of advantages, e.g. long half-lives and cell permeability, making it possible to access a wide range of therapeutic targets. However, finding small molecules that engage “hard-to-drug” protein targets specifically and potently remains an arduous process, requiring experimental screening of extensive compound libraries to identify candidate leads. The search continues with further optimization of compound leads to meet the required potency and toxicity thresholds for clinical applications. Here, we propose a new computational workflow for high-throughput fragment-based screening and binding affinity prediction where we leverage the available protein-ligand complex structures using a state-of-the-art protein surface embedding framework (dMaSIF). We developed a tool capable of finding suitable ligands and fragments for a given protein pocket solely based on protein surface descriptors, that capture chemical and geometric features of the target pocket. The identified fragments can be further combined into novel ligands. Using the structural data, our ligand discovery pipeline learns the signatures of interactions between surface patches and small pharmacophores. On a query target pocket, the algorithm matches known target pockets and returns either potential ligands or identifies multiple ligand fragments in the binding site. Our binding affinity predictor is capable of predicting the affinity of a given protein-ligand pair, requiring only limited information about the ligand pose. This enables screening without the costly step of first docking candidate molecules. Our framework will facilitate the design of ligands based on the target's surface information. It may significantly reduce the experimental screening load and ultimately reveal novel chemical compounds for targeting challenging proteins.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G16B 40/20 - Supervised data analysis

Abstract

22).

IPC Classes  ?

• C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material
• B29B 17/04 - Disintegrating plastics

Abstract

An apparatus for extruding a material, the apparatus comprising: a block which includes two or more extrusion containers composed of heat resisting material, the containers being arranged to receive billets of the extruding material; a die set arranged downstream of the block including the two or more extrusion containers; and one or more rams, wherein the one or more rams are aligned with the axes of the extrusion containers and are arranged to push the billets of material through the extrusion containers into the die set; wherein the die set includes an upper die including two or more extrusion channels for extruding material from each of the extrusion containers, and a lower die incorporating a welding chamber, wherein two or more extruded billets from each of the extrusion channels are welded together and passed out through the exit of the die set.

IPC Classes  ?

• B21C 33/00 - Feeding extrusion presses with metal to be extruded
• B21C 23/06 - Making sheets
• B21C 23/21 - Presses specially adapted for extruding metal
• B21C 25/02 - Dies
• B21C 27/00 - Containers for metal to be extruded

Abstract

The present invention relates to isolated oligonucleotides for treating or preventing inflammation or muscle atrophy. In particular, the invention relates to isolated antisense oligonucleotides which bind to a lncRNA, wherein the lncRNA acts as a molecular sponge for a given miRNA, and wherein the binding of the oligonucleotide to the lncRNA increases the abundance and/or availability of said miRNA in a cell.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Disclosed herein are methods and systems of determining a magnetically induced voltage on a coil of a wireless power transmission device. The method comprises supplying DC input power to the wireless power transmission device. It further comprises monitoring a first variable associated with the wireless power transmission device, and monitoring a second variable associated with the wireless power transmission device, wherein at least one of the first and the second variable is derived from a switching waveform. It further comprises determining, based on at least one of the first variable, the second variable, and the relationship between the first variable and the second variable, the magnetically induced voltage on the coil of the wireless power transmission device.

IPC Classes  ?

• H02J 50/60 - Circuit arrangements or systems for wireless supply or distribution of electric power responsive to the presence of foreign objects, e.g. detection of living beings
• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type

Abstract

The disclosure relates to a valve (20) for use with breathing assistance apparatus. The valve comprises: a valve body (25) defining first, second and third ports (21, 22, 23); a valve core (27) defining a ported chamber (40) rotatable about a valve axis (28) between: a first stable configuration in which the ported chamber provides fluid communication between the first port and the second port and isolates the third port from the first and second ports; and a second stable configuration in which the ported chamber provides fluid communication between the first port and the third port and isolates the second port from the first and third ports, wherein an outer surface (34) of the valve core is configured to engage with an inner surface (32) of the valve body to define a detent for resisting rotation of the valve core between the first stable configuration and the second stable configuration; and an actuator (30) configured to overcome the detent to rotate the valve core between the first and second stable configurations.

IPC Classes  ?

• A61M 16/20 - Valves specially adapted to medical respiratory devices
• F16K 11/083 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only taps or cocks with tapered plug
• F16K 11/085 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only taps or cocks with cylindrical plug
• F16K 31/524 - Mechanical actuating means with crank, eccentric, or cam with a cam
• F16K 31/56 - Mechanical actuating means without stable intermediate position, e.g. with snap action
• F16K 31/60 - Handles

Abstract

An apparatus for generating random numbers, the apparatus comprising one or more bit stream generators, wherein each bit stream generator comprises: a memristor; a pulse generator configured to: generate a plurality of pulses; and apply the plurality of pulses through the memristor to generate an output comprising a plurality of output pulses; and a comparison means configured to: compare a first sample of the pulsed output with a second sample of the pulsed output; and output, based on the first comparison, information indicative of a randomly generated bit of a random bit stream.

IPC Classes  ?

• G06F 7/58 - Random or pseudo-random number generators

Abstract

Systems and methods for ultrasound devices are presented. A system may comprise an ultrasound transducer having a terminal, a driver in electrical communication with the ultrasound transducer via the terminal, and a receiver in electrical communication with the ultrasound transducer via the terminal. The ultrasound transducer is configured to simultaneously transmit and receive a modulated signal and methods allowing for the simultaneous transmission and reception are used.

IPC Classes  ?

• G01S 7/52 - Details of systems according to groups , , of systems according to group
• G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging

Abstract

The present invention relates to methods for the production of immune cells and immunomodulatory cells expressing a transgene of interest, using lentiviral vectors. The invention also relates to populations of cells produced by such methods and uses thereof.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 5/0786 - MonocytesMacrophages
• C12N 15/86 - Viral vectors

Abstract

This disclosure describes a novel “kick and kill” strategy as an effective cancer therapy for treating virus-associated cancers. In particular, this disclosure provides a method of reactivating a latent Epstein-Barr virus (EBV) in a cell infected with the EBV. Also provided are a method of eliciting or enhancing an immune response against an EBV-positive cancer cell in a subject infected with the EBV and a method of treating a subject having cancer associated with EBV infection.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
• A61K 31/4406 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• C07K 14/725 - T-cell receptors
• C07K 16/08 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses

Abstract

The invention relates media, compositions, medium supplements and a method of making same for high-yield culture of fastidious bacteria.

Abstract

The invention relates to a sub-micron particle comprising a payload molecule and a lipid structure being surrounded by an outer layer comprising an amphiphilic copolymer. The invention extends to method of producing the sub-micron particle. The invention also encompasses pharmaceutical compositions and vaccines comprising the sub-micron particle and medical uses thereof.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/145 - Orthomyxoviridae, e.g. influenza virus
• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61P 37/04 - Immunostimulants

Abstract

The present invention relates to biomaterials, in particular bacterial cellulose and provides means to prepare pigmented cellulose at acidic pH 5.8, wherein cellulose pellicles comprising tyrosinase (EC 1.14.18.1) are melanated using a development solution at pH 6 to 8.5 and comprises tyrosine, cysteine and/or cystine. Further, the invention relates to means of preparing spatially restricted pigmented cellulose using an optogenetic expression system wherein two polymerase or transcription factor domains are split and each linked to a light-inducible dimerization domain. The invention provides corresponding methods and components.

IPC Classes  ?

• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
• C12N 1/20 - BacteriaCulture media therefor
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12P 17/10 - Nitrogen as only ring hetero atom

Abstract

The invention relates to gene signatures. In particular, the invention relates methods and kits for diagnosing a subject having a disease, by simultaneously discriminating between multiple infectious and inflammatory diseases using a gene signature. The invention also relates to the use of a gene signature as a diagnostic or prognostic biomarker for diseases.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The invention relates to biomarkers, and to novel biological markers for diagnosing colorectal cancer. In particular, the invention relates to the use of these biomarkers as diagnostic and prognostic markers in assays for detecting colorectal cancer, and corresponding methods of detection. The invention also relates to methods of determining the efficacy of treating colorectal cancer with a therapeutic agent, and apparatus for carrying out the assays and methods. The assays are qualitative and/or quantitative, and are adaptable to large-scale screening and clinical trials.

IPC Classes  ?

• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath

Abstract

A method of manufacturing a fibre comprising a lined channel, using a draw apparatus, the method comprising: providing a preform, comprising a channel extending through the preform, to the draw apparatus; feeding a liner into the channel; heating a portion of the preform; and drawing the heated portion of the preform in order to form a fibre, wherein the liner is held within the channel of the fibre to provide a lined channel within the fibre.

IPC Classes  ?

• B29C 55/22 - Shaping by stretching, e.g. drawing through a dieApparatus therefor of tubes
• A61M 25/00 - CathetersHollow probes
• B29C 55/00 - Shaping by stretching, e.g. drawing through a dieApparatus therefor
• B29K 627/18 - PTFE, i.e. polytetrafluoroethene
• B29L 31/00 - Other particular articles

Abstract

The present invention relates to nucleic acid cassettes for gene therapy, particularly to promoter and promoter/enhancer combinations for improved expression of transgenes in a lung parenchyma‐specific/preferred manner. The invention further relates nucleic acid cassettes comprising said promoters and promoter/enhancer combinations, viral and non‐viral vectors comprising such nucleic acid cassettes, and the use of such nucleic acid cassettes and vectors to increase expression of therapeutic proteins by lung parenchyma cells.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

The present invention relates to an anti-CRISPR construct useful to counteract the spread of a gene-drive in an arthropod population. The invention is also concerned with a system comprising the anti-CRISPR construct and a crispr-based gene-drive construct, a method of producing a genetically modified arthropod, a genetically modified arthropod, and a method for counteracting a CRISPR-based gene-drive in an arthropod population.

IPC Classes  ?

• A01K 67/033 - Rearing or breeding invertebrates; New breeds of invertebrates
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

A device comprising a bendable fibre comprising a fibre axis, a thermally expandable material and a resistance wire extending longitudinally through the fibre spaced apart from the fibre axis; wherein, in use, electrical power applied to the resistance wire causes the temperature of the resistance wire to increase.

IPC Classes  ?

• D01D 5/24 - Formation of filaments, threads, or the like with a hollow structureSpinnerette packs therefor
• B29C 55/22 - Shaping by stretching, e.g. drawing through a dieApparatus therefor of tubes
• B29L 23/00 - Tubular articles
• D01F 8/00 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof
• H05B 3/56 - Heating cables

Abstract

The invention is directed to a method for identifying a candidate anti-glioma drug that is a mitochondrial F1Fo ATP Synthase c-subunit leak channel opener, the method comprising: a. providing an admixture comprising: i. a candidate drug; ii. a submitochondrial vesicle (SMV) preparation; and iii. an H+ probe, wherein the H+ probe remains outside of the SMV(s); b. contacting the admixture with ATP; c. measuring a level of H+ outside of the SMV(s) via the H+ probe; d. comparing the level of H+ at step c) with a level of H+ in a control admixture lacking the candidate drug; and identifying the drug as a candidate anti-glioma drug that is a mitochondrial F1Fo ATP Synthase c-subunit leak channel opener, when the level of H+ is higher compared to the level of H+ in the control admixture; or identifying that the drug is not a candidate anti-glioma drug that is a mitochondrial F1Fo ATP Synthase c-subunit leak channel opener, when the level of H+ is the same or lower compared to the level of H+ in the control admixture.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61K 31/075 - Ethers or acetals
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61P 35/00 - Antineoplastic agents
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Disclosed herein are methods and systems for determining optimal primer sets for a multiplex assay, each of the optimal primer sets intended to amplify one or more targets. The method comprises obtaining amplification data from a plurality of preparatory assays. The amplification data describes at least the amplification of a first target of the one or more targets by a first primer set in a first preparatory assay, the amplification of the first target amplified by a second primer set in a second preparatory assay, the amplification of a second target of the one or more targets by the first primer set in a third preparatory assay, and the amplification of the second target by the second primer set in a fourth preparatory assay. The method further comprises determining a plurality of similarity metrics, each similarity metric being indicative of a degree of similarity between the amplification data produced by one of the plurality of preparatory assays compared to another one of the preparatory assays. The method further comprises determining, based on the plurality of similarity metrics, the optimal primer sets for the multiplex assay.

IPC Classes  ?

• G16B 25/20 - Polymerase chain reaction [PCR]Primer or probe designProbe optimisation
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR

Abstract

The present disclosure relates to a method and system for measuring electric field at a location in a volume of an electrolytic medium and a method and system for applying an electric field to a location in a volume of an electrolytic medium. An aspect of the disclosure provides a method of determining an electric field at a location in a volume of an electrolytic medium, the method comprising: applying, to the location, acoustic energy having a first frequency; sensing an electric field for the volume to obtain a sensed electric field signal; determining, based on the sensed electric field signal and based on a reference signal having the first frequency, the electric field at the location, the electric field at the location having a second frequency.

IPC Classes  ?

• A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
• A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/40 - Applying electric fields by inductive or capacitive coupling
• G01R 29/14 - Measuring field distribution

Abstract

An injection device comprising: a first barrel for containing a first fluid, and having a first plunger; a second barrel for containing a second fluid, and having a second plunger, the second barrel being arranged to one side of the first barrel; a flow converging chamber in fluid communication with the second barrel, for receiving, in use, a flow of the second fluid from the second barrel when the second plunger is advanced within the second barrel; a first inlet to the flow converging chamber, in communication with the first barrel, for receiving, in use, a flow of the first fluid from the first barrel when the first plunger is advanced within the first barrel, simultaneously with the advancement of the second plunger, and arranged to introduce the flow of the first fluid in a concentric manner within the flow of the second fluid, at a meeting point within the flow converging chamber, to produce a concentric flow of the first fluid within the second fluid; and an outlet of the flow converging chamber, for outwardly delivering the concentric flow of the first fluid within the second fluid. The first fluid may contain biological materials such as cells, and may for example comprise a hydrogel. The second fluid may comprise an aqueous fluid such as phosphate-buffered saline. Also provided is a method of delivering a concentric flow of a first fluid within a second fluid, using such an injection device.

IPC Classes  ?

• B01L 3/02 - BurettesPipettes

Abstract

The present disclosure relates to a microfluidic device for discriminating between second cells, as a function of binding strength between first cells and the second cells, the device comprising: a microfluidic channel, a base of the channel comprising a substrate; wherein the channel is configured to receive first cells, for adhesion of the first cells to the substrate; receive second cells, for adhesion of the second cells to the first cells; and receive a fluid, for fluid flow over the second cells; and wherein a transverse cross-section of the channel is configured for application of a substantially uniform shear stress to the second cells that are adhered to the first cells in at least a central region of the channel as the fluid flows along the channel, to detach at least some of the second cells from the first cells, and to cause the detached second cells to flow towards a downstream end of the channel.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 33/483 - Physical analysis of biological material

Abstract

The present invention relates to the use of ultrasound imaging techniques and computer implemented image processing methods for determining and assessing male infertility, as well as non-invasive diagnostic methods to identify and diagnose male infertility, such as hypogonadism (testosterone deficiency). Furthermore, the invention relates to methods of selecting male subjects for fertility treatment and methods for the treatment of these subjects. There is described a computer-implemented method for assessing testicular function in a male subject, the method comprising: receiving one or more ultrasound image collected using contrast-enhanced ultrasound (CEUS) and/or super-resolution ultrasound (SRUS); determining one or more testicular parameters from the one or more ultrasound images; comparing the one or more parameters to one or more threshold values of the one or more parameters; determining a difference between the one or more parameters and the one or more threshold values; and outputting an indication of testicular function based on the comparison of the one or more parameters with the one or more threshold values.

IPC Classes  ?

• A61B 8/08 - Clinical applications
• G03B 42/00 - Obtaining records using waves other than optical wavesVisualisation of such records by using optical means

Abstract

The invention relates to phage vectors, and to novel phage vectors comprising transgenes, in particular conventional mammalian transgene cassettes. The invention extends to the use of such phage vectors as a research tool, and for the delivery of transgenes in a variety of gene therapy applications, DNA and/or peptide vaccine delivery and imaging techniques.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

The present disclosure is related to processes for the manufacture of electrolyte-gated graphene field effect transistors comprising deposition of ink compositions comprising graphene to form conductive films comprising graphene and the use of said transistors as chemo- and bio-sensors.

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

An antibody or antigen-binding fragment thereof is described which binds to the spike protein S2 domain of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV) and/or severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). The antibodies can be used in the diagnosis and treatment of coronavirus infection. The invention extends to compositions comprising the antibodies, including pharmaceutical compositions, diagnostic compositions, and kits. The invention also extends to methods of making and using the antibodies, for example in the diagnosis and therapy of coronavirus infections.

IPC Classes  ?

• A61K 39/42 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum viral
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 31/14 - Antivirals for RNA viruses
• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

An apparatus for a diagnostic testing device, the diagnostic testing device comprising a plunger for delivering a fluid for use in a diagnostic test, the apparatus comprising: a wire-based muscle-like actuator; circuitry configured to heat, and cause a corresponding contraction of, the wire-based muscle-like actuator; and a lever mechanically coupled to the wire-based muscle-like actuator such that contraction of the wire-based muscle-like actuator actuates the lever from a first position to a second position for activating the plunger to deliver the fluid.

IPC Classes  ?

• F16K 31/00 - Operating meansReleasing devices
• B01L 3/02 - BurettesPipettes
• G05D 23/02 - Control of temperature without auxiliary power with sensing element expanding and contracting in response to changes of temperature

Abstract

The present invention relates to chimeric antigen receptor (CAR)-T cells, and particularly, although not exclusively, to their use in immunotherapy, and for treating, preventing or ameliorating cancer, such as T-cell lymphomas, various microbial infections, such as HIV and TB, and also autoimmune disease. The invention is especially concerned with the use of CAR-engineered mucosal-associated invariant T (MAIT) cells, and to novel methods for stimulating, isolating, and expanding highly purified MAIT cells, which can then be engineered into such CAR-MAIT cells. The invention is also concerned with methods for expansion of MAIT cells in vitro.

IPC Classes  ?

• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/02 - Antineoplastic agents specific for leukemia
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 15/86 - Viral vectors

Abstract

The present invention relates to chimeric antigen receptor (CAR)-T cells, and particularly, although not exclusively, to anti-T-cell receptor (TCR) V-beta CARs, and to their use in immunotherapy, and for treating, preventing or ameliorating cancer, such as T-cell lymphomas, various microbial infections, such as HIV and TB, and also autoimmune disease. The invention is especially concerned with the use of CAR-engineered mucosal-associated invariant T (MAIT) cells, and to novel methods for stimulating, isolating and expanding highly purified MAIT cells, which can then be engineered into such CAR-MAIT cells. The invention extends to genetic constructs per se, and to their use in generating the CAR-MAIT cells, and to transduced CAR-MAIT cells per se. The invention also extends to various medical uses of the constructs and transduced CAR-MAIT cells, and to pharmaceutical compositions comprising these constructs and CAR-MAIT cells.

IPC Classes  ?

• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/02 - Antineoplastic agents specific for leukemia
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

The invention relates to genetic constructs, and in particular to genetic constructs for use in population suppression, and pest control. The invention particularly relates to genetic constructs capable of disrupting a haplo-sufficient gene needed for survival or reproduction in an organism, wherein the genetic construct encodes a genomic editor that creates a dominant lethal or sterile mutation in a target gene of the organism. The invention is also concerned with methods of suppressing wild-type populations by use of the genetic constructs described herein.

IPC Classes  ?

• A01K 67/033 - Rearing or breeding invertebrates; New breeds of invertebrates
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, for example in a method of treatment. There are also provided processes for producing compounds of the present invention and method of their use. In particular, the present invention relates to compounds of formula (I). This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, for example in a method of treatment. There are also provided processes for producing compounds of the present invention and method of their use. In particular, the present invention relates to compounds of formula (I).

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• C07F 9/6561 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

The present invention relates to nucleic acid cassettes for gene therapy, particularly to nucleic acid cassettes encoding therapeutic proteins in combination with exogenous signal peptides. The invention further relates to viral and non-viral vectors comprising such nucleic acid cassettes, and the use of such nucleic acid cassettes and vectors to increase expression of therapeutic proteins by airway cells.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 14/535 - Granulocyte CSFGranulocyte-macrophage CSF
• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
• C07K 14/81 - Protease inhibitors
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
• C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)
• C12N 15/86 - Viral vectors

Abstract

The invention relates to methods for determining if a pea variety or a product derived from that pea variety has improved digestion properties. The invention also relates to methods of improving the digestion property of a pea, as well as method of making such plants.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• A23L 33/21 - Addition of substantially indigestible substances, e.g. dietary fibres
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
• G01N 33/02 - Food

Abstract

Disclosed herein is a photoplethysmography (PPG) system for health monitoring. The system comprises a first sensor array configured to collect first PPG data and configured for attachment to a patient at a first sensing site; a second senor array configured to collect second PPG data and configured for attachment to the patient at a second sensing site; and one or more processors configured to receive the first and second PPG data and determine, based on the first and second PPG data and a known distance between the first and second sensing site, a blood pressure value for the patient.

IPC Classes  ?

• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/01 - Measuring temperature of body parts
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition

Abstract

The present invention relates to chimeric antigen receptor (CAR)-T cells, and particularly, although not exclusively, to anti-CD4 CARs, and to their use in immunotherapy, and for treating, preventing or ameliorating cancer, such as T-cell lymphomas, various microbial infections, such as HIV and TB, and also autoimmune disease. The invention is especially concerned with the use of CAR-engineered mucosal-associated invariant T (MAIT) cells, and to novel methods for stimulating, isolating and expanding highly purified MAIT cells, which can then be engineered into such CAR-MAIT cells. The invention extends to genetic constructs per se, and to their use in generating the CAR-MAIT cells, and to transduced CAR-MAIT cells per se. The invention also extends to various medical uses of the constructs and transduced CAR-MAIT cells, and to pharmaceutical compositions comprising these constructs and CAR-MAIT cells.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/02 - Antineoplastic agents specific for leukemia
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/71 - ReceptorsCell surface antigensCell surface determinants for growth factorsReceptorsCell surface antigensCell surface determinants for growth regulators
• C07K 14/725 - T-cell receptors
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
• C12N 15/86 - Viral vectors

Abstract

This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production using a new library of compounds.

IPC Classes  ?

• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 5/0789 - Stem cellsMultipotent progenitor cells
• A61K 31/33 - Heterocyclic compounds

Abstract

The invention relates to compounds of Formula (I): and related aspects. The invention relates to compounds of Formula (I): and related aspects.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• C07D 487/08 - Bridged systems
• C07D 495/04 - Ortho-condensed systems

Abstract

The present invention relates to antibiotic-resistant bacteria, and to the prevention or treatment of infections of drug-resistant pathogens, such as carbapenem-resistant Enterobacteriaceae (CRE) and/or vancomycin-resistant Enterococcus (VRE). In particular, the invention relates to the treatment or prevention of colonisation of CRE and/or VRE in the gastrointestinal (GI) tract, before they cause invasive infections, for example in the blood. The invention provides novel formulations, pharmaceutical compositions and methods of using them to prevent or treat CRE and/or VRE infections or intestinal colonisations thereof.

IPC Classes  ?

• A61K 35/741 - Probiotics
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61P 31/04 - Antibacterial agents

Abstract

An implantable stimulation device is described. The device comprises: signal receiving means for receiving a signal from a heart; and signal delivery means for delivering an output signal to the heart. In response to receiving the signal from the signal receiving means, the implantable stimulation device configured to determine whether the signal is indicative of ventricular tachycardia. Upon positive determination that the signal is indicative of ventricular tachycardia, determine whether the signal is indicative of sustained ventricular tachycardia or spontaneously-terminating ventricular tachycardia. Upon positive determination that the signal is indicative of sustained ventricular tachycardia, send an output signal via the signal delivery means, else if upon positive determination that the signal is indicative of spontaneously-terminating ventricular tachycardia, delay sending the output signal via the signal delivery means.

IPC Classes  ?

• A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

An attachment for use with a device to scan a surface, for example a bony surface, the attachment comprising: a first housing portion configured to releasably secure a device comprising a camera, a second housing portion connected to the first housing portion and having a wall defining an internal region of the second housing portion and an external region of the second housing portion, and a plurality of pins slidably secured to the wall, each of the plurality of pins having a proximal end disposed in the internal region and a distal end disposed in the external region. Upon abutment of the distal end of each of the pins against a surface, the proximal end of each of the pins is configured to translate relative to the wall. When the device is secured to the first housing portion, the proximal ends of the plurality of pins are viewable by the camera.

IPC Classes  ?

• H04N 23/51 - Housings
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• H04M 1/04 - Supports for telephone transmitters or receivers

Abstract

There is provided methods for diagnosing or aiding diagnosis of pulmonary hypertension (PH), pulmonary arterial hypertension (PAH), and/or chronic thromboembolic pulmonary hypertension (CTEPH) in a subject, determining a subject's risk of developing PH, PAH and/or CTEPH, and/or determining a suitable course of treatment for a subject with PH, PAH and/or CTEPH. The present invention also provides kits comprising means for detecting expression of a panel of microRNAs in a sample.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

A method for recycling dye from a dyed textile, the method comprising providing a textile coloured with a dye; adding the textile to a bath comprising a solution of ionic liquid, thereby causing the dye to strip from the textile and to disperse within said solution.

IPC Classes  ?

• D06P 5/13 - Fugitive dyeing or stripping dyes
• D06P 1/00 - General processes of dyeing or printing textiles or general processes of dyeing leather, furs or solid macromolecular substances in any form, classified according to the dyes, pigments or auxiliary substances employed
• D06P 1/66 - Compounds containing ammonium groups containing quaternary ammonium groups
• D06P 1/92 - General processes of dyeing or printing textiles or general processes of dyeing leather, furs or solid macromolecular substances in any form, classified according to the dyes, pigments or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents
• D06P 5/20 - Physical treatments affecting dyeing, e.g. ultrasonic or electric

Abstract

An electrode, comprising a monolithic electrochemically active material which is patterned with a plurality of channels.

IPC Classes  ?

• H01M 4/133 - Electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/1393 - Processes of manufacture of electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

Described herein are processes for preparation of flexible fibres coated in 2-dimensional materials. These fibres are suitable for use in electronic devices and may be woven to form electronic textiles.

IPC Classes  ?

• D06M 11/30 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with halogensTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with halogen acids or salts thereofTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with oxides or oxyacids of halogens or salts thereof with oxides of halogens, oxyacids of halogens or their salts, e.g. with perchlorates
• D06M 11/52 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with sulfur, selenium, tellurium, polonium or compounds thereof with selenium, tellurium, polonium or their compoundsTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with sulfur, selenium, tellurium, polonium or compounds thereof with sulfur, dithionites or compounds containing sulfur and halogens, with or without oxygenTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with sulfur, selenium, tellurium, polonium or compounds thereof by sulfohalogenation with chlorosulfonic acidTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with sulfur, selenium, tellurium, polonium or compounds thereof by sulfohalogenation with a mixture of sulfur dioxide and free halogens
• D06M 11/58 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with nitrogen or compounds thereof, e.g. with nitrides
• D06M 11/74 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with carbon or graphiteTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with carbidesTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with graphitic acids or their salts
• D06P 1/673 - Inorganic compounds

Abstract

The present invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

IPC Classes  ?

• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• A61P 37/02 - Immunomodulators

Abstract

A lid assembly for a sample tube, for collecting magnetic beads from the sample tube and subsequently releasing said beads, the lid assembly comprising: a closure part including means for removably attaching the closure part to the opening of the sample tube, to close the sample tube, and a bead-collecting platform arranged to locate within or above the opening of the sample tube when the closure part is attached to the sample tube, wherein the bead-collecting platform has a bead-collecting surface on one side, for coming into contact with liquid in the sample tube during use, and a magnet-receiving cavity on the other side, behind the bead-collecting surface; and a magnet-bearing part comprising a magnet, wherein the magnet is removably insertable into the magnet-receiving cavity, towards the bead-collecting surface, such that, when the magnet is present within the magnet-receiving cavity, the magnet is capable of holding magnetic beads against the bead-collecting surface, and when the magnet is not present within the magnet-receiving cavity, the lid assembly is incapable of magnetically holding magnetic beads against the bead-collecting surface. Also provided is a method of using such apparatus to collect magnetic beads from a liquid within a sample tube, and associated kits and accessories.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B01L 1/00 - EnclosuresChambers
• B01L 9/06 - Test-tube standsTest-tube holders
• B03C 1/28 - Magnetic plugs and dipsticks

Abstract

A device (1) for use as a physical neural network is described. The device includes a plurality of artificial neurons (2). Each artificial neuron includes a ferromagnetic thin-film nanomagnetic structure (3) having a respective switchable magnetic state. The device is responsive to input data taking the form of a field generated by a control apparatus (5). The input data is for switching one or more of the magnetic states and/or for exerting control over spin-wave dynamics of one or more of the magnetic states. The magnetic states and/or the spin-wave dynamics are readable by one or more sensors (6) to provide output data.

IPC Classes  ?

• G06N 3/044 - Recurrent networks, e.g. Hopfield networks
• G06N 3/045 - Combinations of networks
• G06N 3/065 - Analogue means
• G06N 3/08 - Learning methods