Abstract

The present invention relates to the treatment or prevention of skeletal disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• B29C 48/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired formApparatus therefor
• B29K 25/00 - Use of polymers of vinyl-aromatic compounds as moulding material
• B29K 35/00 - Use of polymers of unsaturated polycarboxylic acids as moulding material
• B29K 201/00 - Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as reinforcement
• B29L 31/00 - Other particular articles
• B32B 27/30 - Layered products essentially comprising synthetic resin comprising vinyl resinLayered products essentially comprising synthetic resin comprising acrylic resin
• C08J 5/18 - Manufacture of films or sheets
• C08L 25/06 - Polystyrene
• C08L 51/04 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers grafted on to rubbers

Abstract

The invention relates to a mould (1) for manufacturing a belt, comprising: - two end elements (8a, 8b) comprising at least one notch (9), such that the belt (2) comprises, at each of its longitudinal ends (5a, 5b), at least one tooth (10), the teeth (10) being complementary in order to interlock when the longitudinal ends (5a, 5b) of the belt (2) are joined; and - at least one mould pin (11) arranged so as to pass through the at least one tooth (10) at the neutral fibre plane of the belt (2). This mould comprises four retaining profiles (13) arranged perpendicular to the side plate (6a, 6b) and configured to hold a traction cable (12) extending between the two mould pins (11) in the neutral fibre plane of the belt (2) at a main zone (2a) of the belt (2).

IPC Classes  ?

• F16G 1/10 - Driving-belts made of rubber with reinforcement bonded by the rubber with textile reinforcement
• F16G 1/12 - Driving-belts made of rubber with reinforcement bonded by the rubber with metal reinforcement
• F16G 1/16 - Driving-belts made of plastics with reinforcement bonded by the plastic material
• F16G 3/02 - Belt fastenings, e.g. for conveyor belts with series of eyes or the like, interposed and linked by a pin to form a hinge
• B29C 45/14 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mouldApparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
• B29D 29/08 - Toothed driving belts
• B29D 29/06 - Conveyor belts
• B29C 65/56 - Joining of preformed partsApparatus therefor using mechanical means
• B29C 65/00 - Joining of preformed partsApparatus therefor
• B29K 105/10 - Condition, form or state of moulded material containing reinforcements, fillers or inserts of continuous length, e.g. cords, rovings, mats, fabrics, strands or yarns oriented
• B29L 30/00 - Pneumatic or solid tyres or parts thereof

Abstract

The invention relates to a method for manufacturing, repairing or modifying a belt (1) for transporting, lifting or transmitting power, the belt (1) comprising at least one cleat (5) and a strip of material (2), the periphery of the strip of material (2) being defined by two opposite faces which are a first face (3a) and a second face (3b) and are connected by two longitudinal edges, the method comprising a step of manufacturing at least one portion of a cleat (5) by depositing successive layers on top of one another on the first face (3a) of the strip of material (2) by a depositing unit (6). This method is characterised in that the angle (7) between the successive layers and the first face (3a) of the strip of material (2) at the cleat (5) is greater than or equal to 10°. The invention also relates to a belt (1) obtained by the method according to the invention.

IPC Classes  ?

• B29D 29/08 - Toothed driving belts

Abstract

The present invention relates to the treatment or prevention of skeletal disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• B29C 48/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired formApparatus therefor
• B29K 25/00 - Use of polymers of vinyl-aromatic compounds as moulding material
• B29K 35/00 - Use of polymers of unsaturated polycarboxylic acids as moulding material
• B29K 201/00 - Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as reinforcement
• B29L 31/00 - Other particular articles
• B32B 27/30 - Layered products essentially comprising synthetic resin comprising vinyl resinLayered products essentially comprising synthetic resin comprising acrylic resin
• C08J 5/18 - Manufacture of films or sheets
• C08L 25/06 - Polystyrene
• C08L 51/04 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers grafted on to rubbers

Abstract

The invention relates to a synchronous belt (1) in particular for lifting, having at least one reinforcing batten (10) for coupling a load thereto, the belt (1) having a strip of material (6) and a traction core (7) embedded in the strip of material (6), the traction core (7) having a plurality of traction cables (8) extending along the longitudinal axis (A) of the strip of material (6). The belt (1) is characterized in that the reinforcing batten (10) is linked to the traction cables (8) by a line (13) wound in the manner of a seam, before being overmoulded in a material that is identical to or chemically compatible with the material of the strip of material (6). It may also have a stiffening bar (12) disposed on the opposite side from the reinforcing batten (10) under the traction cables (8), and linked to the traction cables (8) at the same time as the reinforcing batten (10).

IPC Classes  ?

• B66B 7/06 - Arrangements of ropes or cables
• F16G 1/28 - Driving-belts with a contact surface of special shape, e.g. toothed
• F16G 3/10 - Joining belts by sewing, sticking, vulcanising, or the likeConstructional adaptations of the belt ends for this purpose
• F16G 1/16 - Driving-belts made of plastics with reinforcement bonded by the plastic material

Abstract

The present invention relates to the treatment or prevention of skeletal disorders, at particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3.

IPC Classes  ?

• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• B29C 48/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired formApparatus therefor
• C08J 5/18 - Manufacture of films or sheets
• C08L 51/04 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers grafted on to rubbers
• B32B 27/30 - Layered products essentially comprising synthetic resin comprising vinyl resinLayered products essentially comprising synthetic resin comprising acrylic resin
• C08L 25/06 - Polystyrene
• B29K 25/00 - Use of polymers of vinyl-aromatic compounds as moulding material
• B29K 35/00 - Use of polymers of unsaturated polycarboxylic acids as moulding material
• B29K 201/00 - Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as reinforcement
• B29L 31/00 - Other particular articles

Abstract

The invention concerns a power transmission belt (10) comprising an open band section (16), delimited by two ends (17, 18), assembled by a junction device (40) cooperating with locking rods (42) so as to be able to be at least partially dismounted, arranged to space apart the teeth (14) of the ends (17, 18) by the pitch (P) of the notched face (12) of said belt (10). The notched belt therefore has two use states: an open state allowing it to be mounted on a closed frame or chassis, and a closed state providing traction resistance at least equal to that of a chain or notched belt manufactured as a closed loop. To this end, it comprises a traction core wound around the locking rods (42) provided in said ends (17, 18), the strands of the cables of which are arranged side by side in the median plane of said belt corresponding to the neutral fibre of same. The junction device (40) of same is designed to observe the regular pitch (P) between the teeth and ensure the meshing of the toothed gears (1, 2).

IPC Classes  ?

• F16G 3/02 - Belt fastenings, e.g. for conveyor belts with series of eyes or the like, interposed and linked by a pin to form a hinge
• F16G 1/12 - Driving-belts made of rubber with reinforcement bonded by the rubber with metal reinforcement
• F16G 1/28 - Driving-belts with a contact surface of special shape, e.g. toothed