Abstract

The present invention relates to salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, for use in the treatment and/or prevention of sensory neuron diseases.

IPC Classes  ?

• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to succinate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[t/]imidazol-2-amine and pharmaceutically acceptable solvates thereof, for use in the treatment and/or prevention of motor neuron diseases and neuromuscular junction disorders.

IPC Classes  ?

• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin

Abstract

The present invention relates to succinate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.

IPC Classes  ?

• C07D 235/30 - Nitrogen atoms not forming part of a nitro radical
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, for use in the treatment and/or prevention of motor neuron diseases and neuromuscular junction disorders.

IPC Classes  ?

• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61P 21/04 - Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis

Abstract

NHH-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, for use in the treatment and/or prevention of sensory neuron diseases.

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies

Abstract

The present invention relates to succinate salts of N-(3-(4-(3- (diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[t/]imidazol-2-amine and pharmaceutically acceptable solvates thereof, for use in the treatment and/or prevention of motor neuron diseases and neuromuscular junction disorders.

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 21/04 - Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

NHH-benzo[t/]imidazol-2-amine and pharmaceutically acceptable solvates thereof, for use in the treatment and/or prevention of motor neuron diseases and neuromuscular junction disorders.

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 21/04 - Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

NHdd]imidazol-2-amine and pharmaceutically acceptable solvates thereof, for use in the treatment and/or prevention of motor neuron diseases and neuromuscular junction disorders.

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 21/04 - Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, for use in the treatment and/or prevention of motor neuron diseases and neuromuscular junction disorders.

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 21/04 - Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to succinate salts of N-(3-(4-(3- (diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.

IPC Classes  ?

• C07D 235/30 - Nitrogen atoms not forming part of a nitro radical
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles

Abstract

The present invention relates to succinate salts of N-(3-(4-(3- (diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 235/30 - Nitrogen atoms not forming part of a nitro radical

Goods & Services

Diagnostic preparations for science or research; diagnostic products for science or research; diagnostic reagents for science or research; active chemical ingredients for use in the manufacture of medicines for Alzheimer's disease; active chemical products and/or reagents used in the manufacture of medicines, especially for the treatment of neurodegenerative diseases such as Alzheimer's disease, amyloidopathies, tauopathies and synucleopathies; chemical products and/or reagents used in the manufacture of veterinary products; Chemicals for use in industry and science; chemical reagents other than for medical or veterinary use; vitamins for the manufacture of food supplements. Pharmaceutical products; veterinary products; medicines; active ingredients of medicines; diagnostic agents for medical use; diagnostic preparations for medical use; biomarkers; diagnostic agents for veterinary use; diagnostic preparations for veterinary use; dietetic foods for medical use; dietetic foodstuffs for veterinary use; food supplements; chemical preparations for medical use; chemical preparations for pharmaceutical use; medicinal herbs; herbal teas; food supplements consisting of vitamins; vitamin supplements; vitamin preparations; dietetic preparations and food supplements; dietetic food supplements based primarily on vitamins; dietetic food preparations for medical use; medicated food supplements; nutritional and food supplements; vitamin and mineral supplements; vitamin preparations; nutritional supplements (vitamins or minerals) for medical use; vitamins and minerals; nutraceuticals for therapeutic use; nutraceutical preparations for therapeutic or medical use; nutraceutical products used as dietary supplements. Evaluations, estimates and research in the scientific and technological fields provided by engineers or researchers; research and development in the field of diagnostic products and preparations; research and development of pharmaceutical products and preparations; research and development of medicines; medicine discovery services; technical evaluations concerning design (engineers' services); scientific research; technical research; research and development of new products for third parties; conducting of technical project studies. Medical diagnostic services (testing and analysis); medical services; hospital services; alternative medicine services; provision of information about food supplements and nutrition.

Goods & Services

Diagnostic preparations for science or research; diagnostic products for science or research; diagnostic reagents for science or research; active chemical ingredients for use in the manufacture of medicines for Alzheimer's disease; active synthetic organic chemical products and/or reagents used in the manufacture of medicaments, especially for the treatment of neurodegenerative diseases such as Alzheimer's disease, amyloidopathies, tauopathies and synucleopathies; synthetic organic chemical products and/or reagents used in the manufacture of veterinary products; synthetic organic chemicals for use in industry and science; chemical reagents other than for medical or veterinary use; vitamins for the manufacture of food supplements Pharmaceutical products for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease, amyloidopathies, tauopathies and synucleopathies; medicines; active ingredients of medicines for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease, amyloidopathies, tauopathies and synucleopathies; diagnostic agents for medical use; diagnostic preparations for medical use; diagnostic biomarker reagents for medical purposes; diagnostic agents for veterinary use; diagnostic preparations for veterinary use; dietetic foods adapted for medical use; dietetic foodstuffs adapted for veterinary use; food supplements; chemical preparations for medical use namely for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease, amyloidopathies, tauopathies and synucleopathies ; chemical preparations for pharmaceutical use namely for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease, amyloidopathies, tauopathies and synucleopathies; medicinal herbs; herbal teas for medicinal purposes; food supplements consisting of vitamins; vitamin supplements; vitamin preparations; dietetic preparations adapted for medical purposes and food supplements; dietetic food supplements based primarily on vitamins adapted for medical purposes; dietetic food preparations adapted for medical purpose; medicated food supplements; nutritional and food supplements; vitamin and mineral supplements; vitamin preparations; nutritional supplements consisting primarily of vitamins or minerals for medical use; vitamins and minerals; nutraceuticals for use as a dietary supplement for therapeutic use; nutraceutical preparations for use as a dietary supplement for therapeutic or medical use; nutraceutical products used as dietary supplements Evaluations, estimates and research in the scientific and technological fields of therapeutic treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease, amyloidopathies, tauopathies and synucleopathies, provided by engineers or researchers; research and product development in the field of diagnostic products and preparations; research and development of pharmaceutical products and preparations; research and development of medicines; medicine discovery services in the nature of development of pharmaceutical preparations; engineering services in the form of technical evaluations concerning design for quality control concerning design of new pharmaceutical products; scientific research; technical research in the field of pharmaceutical studies; research and development of new products for third parties; conducting of technical project studies namely, technological research in the field of medical instruments Medical diagnostic services for diagnostic and treatment purposes provided by medical laboratories; medical services; hospital services; alternative medicine services; providing nutrition information

Goods & Services

Diagnostic preparations for use in science or research; Diagnostic products for use in science or research; Diagnostic reagents for use in science or research; Chemical active ingredients for use in the manufacture of medicines against Alzheimer's disease; Active chemical goods and/or reagents for use in the manufacture of medicines, in particular for the treatment of neurodegenerative diseases such as Alzheimer's disease, amyloidopathies, tauopathies and synucleopathies; Active chemical goods and/or reagents for use in the manufacture of veterinary preparations; Chemicals for use in industry and science; Chemical reagents, other than for medical or veterinary purposes; Vitamins for use in the manufacture of food supplements; Active ingredients of medicines. Pharmaceuticals; Veterinary preparations; Medicine; Diagnostic agents for medical use; Diagnostic preparations for medical purposes; biomarkers; Diagnostic agents for veterinary use; Diagnostic preparations for veterinary purposes; Dietetic foods adapted for medical purposes; Dietetic food adapted for veterinary use; Food supplements; Chemical preparations for medical purposes; Chemical preparations for pharmaceutical purposes; Medicinal herbs; Herbal teas for medicinal purposes; Dietary supplements consisting of vitamins; Vitamin supplements; Vitamin preparations; Dietary supplements and dietetic preparations; Health food supplements made principally of vitamins; Dietetic food preparations adapted for medical use; Medicated food supplements; Dietary and nutritional supplements; Vitamin and mineral supplements; Vitamin preparations; nutritional supplement [vitamins or mineral] for medicinal application; Vitamins and minerals; Nutraceuticals for therapeutic purposes; Nutraceutical preparations for therapeutic or medical purposes; Nutraceuticals for use as a dietary supplement. Evaluation, appraisal and research in the scientific and technological fields provided by engineers or researchers; Research and development in the field of diagnostic products and preparations; Research and development of pharmaceutical preparations and products; Research and development of medicines; Drug discovery services; Technical assessments relating to design; Scientific research; Technical research; Research and development of new products for others; Conducting technical project studies. Medical diagnosis (testing and analysis); Medical services; Hospital services; Alternative medicine services; Providing information about dietary supplements and nutrition.

Abstract

The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.

IPC Classes  ?

• C07D 235/30 - Nitrogen atoms not forming part of a nitro radical
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.

IPC Classes  ?

• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 235/30 - Nitrogen atoms not forming part of a nitro radical
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin

Abstract

The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• C07D 491/048 - Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to a compound according to Formula (III) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof and its use.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/16 - Anti-Parkinson drugs

Abstract

The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.

IPC Classes  ?

• C07D 235/30 - Nitrogen atoms not forming part of a nitro radical
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to sulphate salts of N-(3 -(4-(3-(diisobutylamino)propyl)piperazin- 1 -yl)propyl)-1H-benzo [d] imidazol-2-amine andpharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases. Such sulphate salts enable to obtain stable, soluble, crystalline, non-hygroscopic powders of N-(3 -(4-(3 -(diisobutylamino)propyl)piperazin- 1 -yl)propyl)- 1H-benzo [d]imidazol-2-amine.(see above formula)

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 235/30 - Nitrogen atoms not forming part of a nitro radical