Abstract

An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

IPC Classes  ?

• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/28 - DrageesCoated pills or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers

Abstract

The invention relates to a stable pharmaceutical composition comprising comprising a solid dispersion of tacrolimus in a vehicle further comprising e stabilizing agent capable of providing a pH below 7 in the composition, as measured after re-dispersion in water, and preventing or reducing the formation upon storage of major degradation products of tacrolimus, in particular the 8-epitacrolimus.

IPC Classes  ?

• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin

Goods & Services

Pharmaceutical preparations, namely, immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplant patients; pharmaceutical preparations and drug delivery systems, pharmaceutical modified release systems, and pharmaceutical controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, solutions or fluids, all of the above for use in the treatment of physical disorders, emergencies and traumas, burns, diseases of the heart and blood vessels, neurological diseases, and cancer Education and training services, namely, arranging and conducting of seminars, workshops, conferences, lectures and congresses, all in the medical, chemical and pharmaceutical fields Scientific and technological services, namely, scientific research, analysis and testing in the field of medical science, pharmacology, biotechnology and bacteriological areas and providing consultation and information relating thereto; design of drug delivery systems for medical use; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries Medical and pharmaceutical assistance and consultation, namely, medical and pharmaceutical information services, namely, providing medical and scientific research information in the field of pharmaceuticals

Goods & Services

Pharmaceutical preparations, namely, immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplant patients; pharmaceutical preparations and drug delivery systems, pharmaceutical modified release systems, and pharmaceutical controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, solutions or fluids, all of the above for use in the treatment of physical disorders, emergencies and traumas, burns, diseases of the heart and blood vessels, neurological diseases, and cancer. Education and training services, namely, arranging and conducting of seminars, workshops, conferences, lectures and congresses, all in the medical, chemical and pharmaceutical fields. Scientific and technological services, namely, scientific research, analysis and testing in the field of medical science, pharmacology, biotechnology and bacteriological areas and providing consultation and information relating thereto; design of drug delivery systems for medical use; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries. Medical and pharmaceutical assistance and consultation, namely, medical and pharmaceutical information services, namely, providing medical and scientific research information in the field of pharmaceuticals.

Abstract

max than an immediate release formulation of tacrolimus while providing the same or greater area under the curve (AUC), (iii) releases the tacrolimus substantially in the colon and/or the lower ileum, (iv) releases at most 63.5% of the tacrolimus in the dosage form at the 12 hour time point, or (v) any combination of any of the foregoing.

IPC Classes  ?

• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/20 - Pills, lozenges or tablets
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

IPC Classes  ?

• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/28 - DrageesCoated pills or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers

Abstract

An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

IPC Classes  ?

• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/28 - DrageesCoated pills or tablets
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers

Abstract

An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

IPC Classes  ?

• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/28 - DrageesCoated pills or tablets
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers

Abstract

max than an immediate release formulation of tacrolimus while providing the same or greater area under the curve (AUC), (iii) releases the tacrolimus substantially in the colon and/or the lower ileum, (iv) releases at most 63.5% of the tacrolimus in the dosage form at the 12 hour time point, or (v) any combination of any of the foregoing.

IPC Classes  ?

• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The invention relates to a stable pharmaceutical composition comprising comprising a solid dispersion of tacrolimus in a vehicle further comprising a stabilizing agent capable of providing a pH below 7 in the composition, as measured after re-dispersion in water, and preventing or reducing the formation upon storage of major degradation products of tacrolimus, in particular the 8-epitacrolimus.

IPC Classes  ?

• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin

Abstract

max than an immediate release formulation of tacrolimus while providing the same or greater area under the curve (AUC), (iii) releases the tacrolimus substantially in the colon and/or the lower ileum, (iv) releases at most 63.5% of the tacrolimus in the dosage form at the 12 hour time point, or (v) any combination of any of the foregoing.

IPC Classes  ?

• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Goods & Services

(1) Pharmaceutical preparations, namely, immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, all of the above for use in the treatment of cholesterol related diseases, allergy, burns, diseases of the heart and blood vessels, dental and gum diseases, diabetes, diseases and afflictions of the gastroenterological system, cancer, ophthalmological diseases, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalized pain. (1) Development of drug delivery systems for others, namely, development of solid dosage forms, pharmaceutical controlled release systems, modified release systems and pharmaceutical modified release systems and consultation related thereto.

Goods & Services

Pharmaceutical preparations, namely, immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and pharmaceutical preparations, namely, drug delivery systems and drug modified systems comprising tablets, granules, pills, sachets, powders, capsules for controlled release of low water soluble and insoluble drugs, all of the above for use in the treatment of cholesterol related diseases, mental and physical disorders, traumas and emergencies, addictions, aging, allergy and immunology, burns, diseases of the heart and blood vessels, dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, neurological diseases, nephrological diseases, diseases in the obstetrical and gynecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalized pain

Abstract

The invention relates to a stable pharmaceutical composition comprising comprising a solid dispersion of tacrolimus in a vehicle further comprising a stabilizing agent capable of providing a pH below 7 in the composition, as measured after re-dispersion in water, and preventing or reducing the formation upon storage of major degradation products of tacrolimus, in particular the 8-epitacrolimus.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/20 - Pills, lozenges or tablets
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin

Abstract

An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

IPC Classes  ?

• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/28 - DrageesCoated pills or tablets
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers

Abstract

max than an immediate release formulation of tacrolimus while providing the same or greater area under the curve (AUC), (iii) releases the tacrolimus substantially in the colon and/or the lower ileum, (iv) releases at most 63.5% of the tacrolimus in the dosage form at the 12 hour time point, or (v) any combination of any of the foregoing.

IPC Classes  ?

• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Goods & Services

Pharmaceutical preparations, including immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, all of the above i.a. for use in the treatment of mental and physical disorders, traumas and emergencies, addictions, aging, allergy/immunology, burns, diseases of the heart and blood vessels, dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, neurological diseases, nephrological diseases, diseases in the obstetrical and gynaecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalised pain; veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Treatment of materials, namely milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries. Scientific and technological services as well as research and design in connection therewith, including within the medical, pharmaceutical, biotechnical and bacteriological areas and providing consultation and information relating thereto; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries; industrial analysis and research; design and development of computer hardware and computer software. Medical services; medical and pharmaceutical assistance and consultation; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services.

Goods & Services

Pharmaceutical preparations, including immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, all of the above i.a. for use in the treatment of mental and physical disorders, traumas and emergencies, addictions, aging, allergy/immunology, burns, diseases of the heart and blood vessels, dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, neurological diseases, nephrological diseases, diseases in the obstetrical and gynaecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalised pain; veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Treatment of materials, namely milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries. Scientific and technological services as well as research and design in connection therewith, including within the medical, pharmaceutical, biotechnical and bacteriological areas and providing consultation and information relating thereto; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries; industrial analysis and research; design and development of computer hardware and computer software. Medical services; medical and pharmaceutical assistance and consultation; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services.

Goods & Services

(1) Pharmaceutical preparations, namely, an immunotherapeutic and immunosuppressive preparation indicated for the prophylaxis of organ rejection in transplant patients converted from tacrolimus immediate-release formulations in combination with other immune-suppressants, in the form of a pharmaceutical modified and controlled release system, comprised of tablets, granules, pills, sachets, powders, or capsules. (2) Medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, namely, medical formulations delivered in the form of tablets, granules, pills, sachets, powders, capsules, which allow for modified timed release, controlled timed release and targeted release of the formulations, all of the above for use in the treatment of allergy and immunology, namely, autoimmune diseases, immunologic deficiency syndrome; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, namely, medical formulations delivered in the form of tablets, granules, pills, sachets, powders, capsules, which allow for modified timed release, controlled timed release and targeted release of the formulations, all of the above for use in the treatment of nephrological diseases, namely, polycystic kidney disease, acute kidney failure, hypertension. (1) Treatment of materials, namely, milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries. (2) Scientific and technological services, namely, conducting clinical testing and providing research design in the field of clinical trials within the medical, pharmaceutical, biotechnical and bacteriological areas; providing scientific consultation and information in the pharmaceutical, biotechnical and bacteriological fields and providing scientific consultation and information in the medical field relating to pharmaceutical drug delivery systems and immunologic practices to assist in transplant situations. (3) Packaging design for others. (4) Designing and development of medical equipment. (5) Designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granular technology and tablet technology, namely, drug delivery in the form of tablets and pills. (6) Materials testing for the pharmaceutical and medical industries. (7) Medical services, namely, medical and pharmaceutical assistance and consultation, namely, medical and pharmaceutical information services, namely, providing medical and scientific research information in the field of pharmaceuticals.

Goods & Services

(1) Pharmaceutical preparations, namely, an immunotherapeutic and immunosuppressive preparation indicated for the prophylaxis of organ rejection in transplant patients converted from tacrolimus immediate-release formulations in combination with other immune-suppressants, in the form of a pharmaceutical modified and controlled release system, comprised of tablets, granules, pills, sachets, powders, or capsules. (2) Medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, namely, medical formulations delivered in the form of tablets, granules, pills, sachets, powders, capsules, which allow for modified timed release, controlled timed release and targeted release of the formulations, all of the above for use in the treatment of allergy and immunology, namely, autoimmune diseases, immunologic deficiency syndrome; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, namely, medical formulations delivered in the form of tablets, granules, pills, sachets, powders, capsules, which allow for modified timed release, controlled timed release and targeted release of the formulations, all of the above for use in the treatment of nephrological diseases, namely, polycystic kidney disease, acute kidney failure, hypertension. (1) Treatment of materials, namely, milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries. (2) Scientific and technological services, namely, conducting clinical testing and providing research design in the field of clinical trials within the medical, pharmaceutical, biotechnical and bacteriological areas; providing scientific consultation and information in the pharmaceutical, biotechnical and bacteriological fields and providing scientific consultation and information in the medical field relating to pharmaceutical drug delivery systems and immunologic practices to assist in transplant situations. (3) Packaging design for others. (4) Designing and development of medical equipment. (5) Designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granular technology and tablet technology, namely, drug delivery in the form of tablets and pills. (6) Materials testing for the pharmaceutical and medical industries. (7) Medical services, namely, medical and pharmaceutical assistance and consultation, namely, medical and pharmaceutical information services, namely, providing medical and scientific research information in the field of pharmaceuticals.

Abstract

max than an immediate release formulation of tacrolimus while providing the same or greater area under the curve (AUC), (iii) releases the tacrolimus substantially in the colon and/or the lower ileum, (iv) releases at most 63.5% of the tacrolimus in the dosage form at the 12 hour time point, or (v) any combination of any of the foregoing.

IPC Classes  ?

• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 9/20 - Pills, lozenges or tablets
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Goods & Services

[ Treatment of materials, namely, milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, bio technical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries ] Pharmaceutical preparations, namely, immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, [ granules, ] pills [, sachets, powders, capsules, all of the above ] for use in the treatment of [ mental and physical disorders, traumas and emergencies, addictions, aging, allergy, ] immunology, [ burns, ] diseases of the heart and blood vessels, [ dental and gum diseases, skin diseases, nutritional and dietary diseases, ] diseases of the endocrinological system and pancreatic diseases, [ diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, ] neurological diseases, nephrological diseases, [ diseases in the obstetrical and gynaecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and threat, diseases and afflictions in the psychiatric field, ] pulmonological diseases [ and afflictions, rheumatism, urological diseases and afflictions and generalized pain ] [ Scientific and technological services, namely, clinical testing and technology transfer services as well as research and design in connection therewith, namely, within the medical, pharmaceutical, bio technical and bacteriological areas and providing scientific consultation and information relating thereto; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries ] [ Medical services; medical and pharmaceutical assistance and consultation, namely, medical and pharmaceutical information services, namely, providing medical and scientific research information in the field of pharmaceuticals ]

Goods & Services

[ Treatment of materials, namely, milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries ] Pharmaceutical preparations, namely, immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, [ granules, ] pills, [ sachets, powders, capsules, all of the above ] for use in the treatment of [ mental and physical disorders, traumas and emergencies, addictions, aging, allergy, ] immunology, [ burns, ] diseases of the heart and blood vessels, [ dental and gum diseases, skin diseases, nutritional and dietary diseases, ] diseases of the endocrinological system and pancreatic diseases, [ diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, ] neurological diseases, nephrological diseases, [ diseases in the obstetrical and gynaecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, ] pulmonological diseases [ and afflictions, rheumatism, urological diseases and afflictions and generalised pain ] [ Scientific and technological services, namely, clinical testing and technology transfer services as well as research and design in connection therewith, namely, within the medical, pharmaceutical, biotechnical and bacteriological areas and providing scientific consultation and information relating thereto; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries ] [ Medical services; medical and pharmaceutical assistance and consultation, namely, medical and pharmaceutical information services, namely, providing medical and scientific research information in the field of pharmaceuticals ]

Goods & Services

Pharmaceutical preparations, namely, immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, [ granules, ] pills, [ sachets, powders, capsules, all of the above ] for use in the treatment of [ mental and physical disorders, traumas and emergencies, addictions, aging, allergy and ] immunology, [ burns, ] diseases of the heart and blood vessels, [ dental and gum diseases, skin diseases, nutritional and dietary diseases, ] diseases of the endocrinological system and pancreatic diseases, [ diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, ] neurological diseases, nephrological diseases, [ diseases in the obstetrical and gynecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, ] pulmonological diseases [ and afflictions, rheumatism, urological diseases and afflictions and generalised pain ] [ Medical services ]

Abstract

The invention relates to a stable pharmaceutical composition comprising comprising a solid dispersion of tacrolimus in a vehicle further comprising a stabilizing agent capable of providing a pH below 7 in the composition, as measured after re-dispersion in water, and preventing or reducing the formation upon storage of major degradation products of tacrolimus, in particular the 8-epitacrolimus.

IPC Classes  ?

• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/20 - Pills, lozenges or tablets

Goods & Services

Pharmaceutical preparations, including immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, granules; pills, sachets, powders, capsules, all of the above inter alia for use in the treatment of mental and physical disorders, traumas and emergencies, addictions, aging, allergy/immunology, burns, diseases of the heart and blood vessels, dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, neurological diseases, nephrological diseases, diseases in the obstetrical and gynecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalised pain; veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Scientific and technological services as well as research and design in connection therewith, including within the medical, pharmaceutical, biotechnical and bacteriological areas and providing consultation and information relating thereto; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries; industrial analysis and research; design and development of computer hardware and computer software. Medical services; medical and pharmaceutical assistance and consultation; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services.

Goods & Services

Pharmaceutical preparations, including immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, all of the above i.a. for use in the treatment of mental and physical disorders, traumas and emergencies, addictions, aging, allergy/immunology, burns, diseases of the heart and blood vessels, dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, neurological diseases, nephrological diseases, diseases in the obstetrical and gynecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalised pain; veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Treatment of materials, including milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries. Scientific and technological services as well as research and design in connection therewith, including within the medical, pharmaceutical, biotechnical and bacteriological areas and providing consultation and information relating thereto; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries; industrial analysis and research; design and development of computer hardware and computer software. Medical services; medical and pharmaceutical assistance and consultation; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services.

Goods & Services

[ Treatment of materials, namely, milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries ] Pharmaceutical preparations, namely, immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, all of the above for use in the treatment of mental and physical disorders, traumas and emergencies, addictions, aging, allergy and immunology, burns, diseases of the heart and blood vessels, dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, neurological diseases, nephrological diseases, diseases in the obstetrical and gynecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalised pain [ Scientific and technological services, namely, clinical testing and technology transfer services as well as research and design in connection therewith, namely, within the medical, pharmaceutical, biotechnical and bacteriological areas and providing scientific consultation and information relating thereto; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries ] [ Medical services; medical and pharmaceutical assistance and consultation, namely, medical and pharmaceutical information services, namely, providing medical and scientific research information in the field of pharmaceuticals ]

Goods & Services

Pharmaceutical preparations, including immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, solutions or fluids, all of the above ia for use in the treatment of mental and physical disorders, traumas and emergencies, addictions, aging, allergy/immunology, burns, diseases of the heart and blood vessels, dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, neurological diseases, nephrological diseases, diseases in the obstetrical and gynaecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalised pain; veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Treatment of materials, including milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries. Scientific and technological services as well as research and design in connection therewith, including within the medical, pharmaceutical, biotechnical and bacteriological areas and providing consultation and information relating thereto; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries; industrial analysis and research; design and development of computer hardware and computer software. Medical services; medical and pharmaceutical assistance and consultation, including medical and pharmaceutical information services; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services.

Abstract

The invention provides stable, solid dosage forms and pharmaceutical compositions in particulate form comprising a fibrate, for example fenofibrate, dissolved in an non-aqueous vehicle in order to ensure improved bioavailability of the active ingredient upon oral administration relative to known fibrate formulations.

IPC Classes  ?

• A61K 9/20 - Pills, lozenges or tablets

Abstract

An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

IPC Classes  ?

• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin

Goods & Services

Pharmaceutical preparations, including immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, solutions or fluids, all of the above i.a. for use in the treatment of mental and physical disorders, traumas and emergencies, addictions, aging, allergy/immunology, burns, diseases of the heart and blood vessels, dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, neurological diseases, nephrological diseases, diseases in the obstetrical and gynecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalised pain; veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Treatment of materials, including milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries. Education and training services, including arranging and conducting of seminars, workshops, conferences, lectures and congresses, all in the medical, chemical and pharmaceutical fields. Scientific and technological services as well as research and design in connection therewith, including within the medical, pharmaceutical, biotechnical and bacteriological areas and providing consultation and information relating thereto; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries; industrial analysis and research; design and development of computer hardware and computer software. Medical services; medical and pharmaceutical assistance and consultation, including medical and pharmaceutical information services; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services. Legal services; consultancy services regarding intellectual property; licensing of intellectual property.

Goods & Services

Pharmaceutical and veterinary medical preparations, including for physical and mental diseases.

Goods & Services

Pharmaceutical preparations, including immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplantation patients; medical preparations and drug delivery systems, pharmaceutical modified release systems, and controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, solutions or fluids, all of the above i.a, for use in the treatment of mental and physical disorders, traumas and emergencies, addictions, aging, allergy/ immunology, burns, diseases of the heart and blood vessels, dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, neurological diseases, nephrological diseases, diseases in the obstetrical and gynecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalized pain; veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Treatment of materials, including milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries. Education and training services, including arranging and conducting of seminars, workshops, conferences, lectures and congresses, all in the medical, chemical and pharmaceutical fields. Scientific and technological services as well as research and design in connection therewith, including within the medical, pharmaceutical, biotechnical and bacteriological areas and providing consultation and information relating thereto; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries; industrial analysis and research; design and development of computer hardware and computer software. Medical services; medical and pharmaceutical assistance and consultation, including medical and pharmaceutical information services; veterinary services; hygienic and beauty care for human beings or animals; agriculture, horticulture and forestry services. Legal services; consultancy services regarding intellectual property; licensing of intellectual property.

Goods & Services

Pharmaceutical preparations, namely, immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplant patients; pharmaceutical preparations and drug delivery systems, pharmaceutical modified drug delivery release systems, and pharmaceutical controlled drug delivery release systems, comprised of tablets, granules, pills, sachets, powders, capsules, solutions or fluids, all of the above for use in the treatment of mental and physical disorders, emergencies and traumas, aging, namely, Alzheimer's disease, arthritis, shock, immune system diseases, allergies and burns, diseases of the heart and blood vessels, dental and gum diseases, skin diseases, nutritional and dietary disorders, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, neurological diseases, nephrological diseases, gynecological diseases, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, psychiatric diseases and disorders, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalized pain [ Treatment of materials, namely, milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries ] Education and training services, namely, arranging and conducting of seminars, workshops, conferences, lectures and congresses, all in the medical, chemical and pharmaceutical fields Scientific and technological services, namely, scientific research, analysis and testing in the field of medical science, pharmacology, biotechnology and bacteriological areas and providing consultation and information relating thereto; design of drug delivery systems for medical use; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries Medical and pharmaceutical assistance and consultation, namely, medical and pharmaceutical consultation, pharmaceutical advice, providing information relating to diagnostic, prophylactic and therapeutic properties of pharmaceuticals [ Consulting in the field of intellectual property licensing; licensing of intellectual property ]

Goods & Services

Pharmaceutical preparations, namely, immunotherapeutic and immunosuppressive preparations for medical use for treatment of transplant patients; pharmaceutical preparations and drug delivery systems, pharmaceutical modified release systems, and pharmaceutical controlled release systems, comprised of tablets, granules, pills, sachets, powders, capsules, solutions or fluids, all of the above for use in the treatment of [ mental and ] physical disorders, emergencies and traumas, [ aging, allergy and immunology, ] burns, diseases of the heart and blood vessels, [ dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, diseases of the blood, infectious diseases, ] neurological diseases, [ nephrological diseases, diseases in the obstetrical and gynecological field, ] cancer [, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalized pain ] [ Treatment of materials, namely, milling, grinding, mixing, compressing, and melting of pharmaceutical, medicinal, biotechnical and bacteriological substances, preparations, formulations and solutions, for use in the pharmaceutical and medical industries ] Education and training services, namely, arranging and conducting of seminars, workshops, conferences, lectures and congresses, all in the medical, chemical and pharmaceutical fields Scientific and technological services, namely, scientific research, analysis and testing in the field of medical science, pharmacology, biotechnology and bacteriological areas and providing consultation and information relating thereto; design of drug delivery systems for medical use; conducting of tests regarding medical applications; packaging design for others; designing and development of medical equipment; designing pharmaceutical medical preparations; development of pharmaceutical formulations; design and development of granulation technology and tablet technology and providing consultation and information thereto; materials testing for the pharmaceutical and medical industries Medical and pharmaceutical assistance and consultation, namely, medical and pharmaceutical information services, namely, providing medical and scientific research information in the field of pharmaceuticals [ Consultancy services regarding intellectual property; licensing of intellectual property; medical and pharmaceutical assistance and consultation, including medical and pharmaceutical information services ]

Abstract

An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

IPC Classes  ?

• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin

Abstract

Stable tablets and pharmaceutical compositions in particulate form comprising a fibrate, for example fenofibrate, dissolved or dispersed in an non-aqueous vehicle with improved bioavailability, thereby eliminating the food effect so that the tablet or composition can be administered to a patient irrespective of being in fed or fasted state.

IPC Classes  ?

• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid

Abstract

A modified release composition comprising tacrolimus releases less than 20% w/w of the active ingredient within 0.5 hours when subjected to an in vitro dissolution test using USP Paddle method and using 0.1 N HCl as dissolution medium and has increased bioavailability by effectively reducing or even avoiding the effects of CYP3A4 metabolism. The modified composition may be coated with an enteric coating; and/or may comprise a solid dispersion or a solid solution of tacrolimus in a hydrophilic or water-miscible vehicle and one or more modifying release agents; and/or may comprise a solid dispersion or a solid solution of tacrolimus in an amphiphilic or hydrophobic vehicle and optionally one or more modifying release agents.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders

Goods & Services

[ Pharmaceutical preparations; medical preparations; and drug delivery systems, ] pharmaceutical modified release systems, and controlled release systems, comprised of tablets, [ granules, pills, sachets, powders, and capsules; ] all of the above for use in the treatment of [ mental and physical disorders, traumas and emergencies, addictions, aging, allergy/immunology, burns, ] diseases of [ the heart and ] blood vessels, [ dental and gum diseases, skin diseases, nutritional and dietary diseases, diseases of the endocrinological system and pancreatic diseases, diabetes, epidemical diseases, diseases and afflictions of the gastroenterological system, ] diseases of the blood, [ infectious diseases, neurological diseases, nephrological diseases, diseases in the obstetrical- and gynecological field, cancer, ophthalmological diseases, diseases and afflictions affecting the bones, joints, cartilage material and muscles, diseases and afflictions of the ear, nose and throat, diseases and afflictions in the psychiatric field, pulmonological diseases and afflictions, rheumatism, urological diseases and afflictions and generalised pain ] [ Educational training services, namely, arranging and conducting of seminars, workshops, conferences, lectures and congresses, all in the medical, chemical, and pharmaceutical fields ] [ Scientific research, namely, bacteriological research, biological research, biotechnological research, scientific research services for medical purposes and scientific research consultation; research and development for new products for others; industrial design services; pharmaceutical and medical consultation regarding pharmaceutical drug development services; cosmetic research for others; design services for others in the field of medical packaging and equipment; medical research; medical and scientific research, namely, conducting clinical trials, namely, testing of medical substances and testing of medical applications; pharmaceutical drug development services, namely, development of medical applications, drug design, drug formulation, pharmaceutical formulation, and development of pharmaceutical formulations and consultation regarding pharmaceutical formulation; ] development of drug delivery systems for others, namely, development of solid dosage forms, pharmaceutical controlled release systems, modified release systems and pharmaceutical modified release systems and consultation related thereto; [ pharmaceutical drug development services, namely, development of mixing technology, development of particulate material, development of particulate material mixing technology, development of granulate technology, development of tabletting technology, and consultation related thereto ]

Goods & Services

Pharmaceutical and veterinary preparations, including for physical and mental illnesses, sanitary preparations for medical purposes, dietetic substances adapted for medical use, disinfectants; fungicides, herbicides. Treatment of materials. Education; arrangement of and conducting seminars, workshops, conferences, lectures and congresses. Scientific research within the medical, pharmaceutical and bacteriological area including consultancy and information relating thereto, conducting of tests regarding medical applications; packaging design, designing and development of medical equipment, designing pharmaceutical and medical preparations, preparation of pharmaceutical formulations, design and development of granulation technology and tablet technology including consultancy and information relating thereto.