The current invention pertains to a use of collagen hydrolysate as an active ingredient in ameliorating sleep. The collagen hydrolysate is preferably used in absence of other sleep-enhancing compounds, to achieve the highest sleep-enhancing effects and/or to not counteract the inherent sleep-enhancing effects of collagen hydrolysate. The invention furthermore pertains to a ccomposition comprising at least 97.5 wt. %, preferably 97.5 wt. % collagen hydrolysate as active ingredient and no more than 2.5 wt. %, preferably 2.5 wt. % of one or more further compounds capable of modulating sleep. The invention also pertains to a sleep-ameliorating composition, consisting essentially of collagen hydrolysate and/or comprising essentially no further compound capable of modulating sleep.
The present invention relates to a method for reducing lipopolysaccharides activity and/or lipopolysaccharides in a collagen-containing and/or collagen-derived product and products obtained by the method. The method comprises the steps of providing a collagen-containing and/or collagen-derived product comprising lipopolysaccharides, contacting the collagen-containing and/or collagen-derived product comprising lipopolysaccharides with a polyglycol ether of a fatty alcohol to provide a mixture and recovering a collagen-containing and/or collagen-derived product.
The present invention relates to a hydrolyzed collagen formulation for use in decreasing blood glucose. The hydrolyzed collagen is obtained by enzymatic hydrolysis of a collagen-containing material with a combination of enzymes comprising two or more enzymes selected from the group consisting of a neutral protease, a carboxypeptidase, and an aminopeptidase. The hydrolyzed collagen formulation is particularly suitable as a food supplement, such as for use in ameliorating hyperglycemia and/or a risk factor hyperglycemia.
The present invention pertains to a cyclic analogue of glycine-proline for use in the prevention and/or treatment of fibrosis, for example skin fibrosis, hypertrophic scars, keloids, organ-specific fibrosis or implant-related fibrosis. The peptide of the invention can be administered orally, but also instance provided in a topical formulation or cosmetic composition. Moreover, the peptide of the invention can be provided as a coating on an implantable device and/or medical device, to prevent excess fibrosis and encapsulation thereof.
The present invention relates to the use of collagen hydrolysate in the prevention and/or treatment of food craving. The collagen hydrolysate may have a therapeutic and/or non-therapeutic effect. The prevention and/or treatment of craving by the collagen hydrolysate may find purpose in losing bodyweight or improving general well-being. The collagen hydrolysate is preferably administered as a daily food supplement formulation.
The present invention relates to a composition comprising chondroitin sulfate and collagen hydrolysate, for use in ameliorating pain, preferably for use in ameliorating joint pain after exercise. The present invention furthermore relates to a method of preparing said composition by hydrolysis of a collagen-containing material comprising different types of collagen. The composition is preferably administered as a food supplement.
The present invention relates to a use of collagen hydrolysate after intensive care unit (ICU) stay. The collagen hydrolysate improves the recovery and prevents and/or treats post intensive care syndrome (PICS) after ICU stay. The collagen hydrolysate is preferably administered as a supplement in the context of ICU stay and/or PICS. Collagen hydrolysate is generally-accepted to be safe and therefore can be taken as a preventive and long-term measure.
The current invention pertains to a use of gelatin in a support material for embedded printing. The current invention furthermore pertains to a method for preparing a gelatin support material for embedded printing and a gelatin support material, optionally obtainable by the method. The invention furthermore pertains to a method for embedded printing using a gelatin support material. In the context of the invention, the gelatin has an average molecular weight of 50 – 250 kDa and preferably is in a fluid bulk, single-phase and non-crosslinked form.
The present invention relates to a method for reducing lipopolysaccharides activity and/or lipopolysaccharides in a collagen-containing and/or collagen-derived product and products obtained by the method. The method comprises the steps of providing a collagen-containing and/or collagen-derived product comprising lipopolysaccharides, contacting the collagen- containing and/or collagen-derived product comprising lipopolysaccharides with a polyglycol ether of a fatty alcohol to provide a mixture and recovering a collagen-containing and/or collagen-derived product.
The invention relates to a Gelatin functionalised via an amide bond with a substituted cross-linkable carboxylic acid moiety R—(CH2)n—COOH wherein n is an integer form 1 to 10 and further having a lipopolysaccharide content of less than 100 EU/g as well as a method for its preparation using an N-hydroxysuccinimide ester of the substituted cross-linkable carboxylic acid.
The current invention pertains to a use of collagen hydrolysate as an active ingredient in ameliorating sleep. The collagen hydrolysate is preferably used in absence of other sleep- enhancing compounds, to achieve the highest sleep-enhancing effects and/or to not counteract the inherent sleep-enhancing effects of collagen hydrolysate. The invention furthermore pertains to a ccomposition comprising at least 97.5 wt.%,preferably 97.5 wt.% collagen hydrolysate as active ingredient and no more than 2.5 wt.%, preferably 2.5 wt.% of one or more further compounds capable of modulating sleep. The invention also pertains to a sleep-ameliorating composition, consisting essentially of collagen hydrolysate and/or comprising essentially no further compound capable of modulating sleep.
The present invention relates to a cryopreservation formulation comprising collagen hydrolysate and preferably comprising dimethylsulfoxide. The present furthermore relates to a method for cryopreservation of one or more biological materials, the method comprising the step of providing the one or more biological materials in the cryopreservation formulation comprising collagen hydrolysate and preferably dimethylsulfoxide. The present invention also relates to a use of the cryopreservation formulation comprising collagen hydrolysate and preferably dimethylsulfoxide for cryopreservation of one or more biological materials selected from the group consisting of an eukaryotic cell, a prokaryotic cell, a cell organelle, an extracellular vesicle, an organoid, a tissue, and an organ. The present invention also relates to a use of collagen hydrolysate, preferably in combination with dimethylsulfoxide, in preparing a cryopreservation formulation.
The present invention relates to a use of collagen hydrolysate after intensive care unit (ICU) stay. The collagen hydrolysate improves the recovery and prevents and/or treats post intensive care syndrome (PICS) after ICU stay. The collagen hydrolysate is preferably administered as a supplement in the context of ICU stay and/or PICS. Collagen hydrolysate is generally-accepted to be safe and therefore can be taken as a preventive and long-term measure.
The present invention relates to a hydrolyzed collagen formulation for use in decreasing blood glucose. The hydrolyzed collagen is obtained by enzymatic hydrolysis of a collagen- containing material with a combination of enzymes comprising two or more enzymes selected from the group consisting of a neutral protease, a carboxypeptidase, and an aminopeptidase. The hydrolyzed collagen formuluation is particularly suitable as a food supplement, such as for use in ameliorating hyperglycemia and/or a risk factor hyperglycemia.
The present invention relates to a composition comprising chondroitin sulfate and collagen hydrolysate, for use in ameliorating pain, preferably for use in ameliorating joint pain after exercise. The present invention furthermore relates to a method of preparing said composition by hydrolysis of a collagen-containing material comprising different types of collagen. The composition is preferably administered as a food supplement.
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
The present invention provides a method for producing a seamless centre filled gummy; wherein the filling comprises at least one active ingredient; the method comprising the steps of: 1) preparing a gelatinous shell composition by a first gelatine product in water to form a first gelatine solution; 2) preparing a filling composition, wherein the filling composition comprises at least one bulking agent and one or more active ingredients dissolved or suspended in said filling composition; 3) depositing the gelatinous shell composition and the filling composition within the same timeframe; 4) setting the deposited gelatinous shell composition; wherein the temperature Tinner of the filling composition upon deposition is at most 45° C., and wherein the viscosity of the filling composition upon deposition ranges between 500 and 30000 mPa·s. The invention further provides seamless centre filled gummy comprising an active ingredient, which may be produced by the inventive method.
A23G 3/54 - Composite products, e.g. layered, coated, filled
A23G 3/34 - Sweetmeats, confectionery or marzipanProcesses for the preparation thereof
A23G 3/42 - Sweetmeats, confectionery or marzipanProcesses for the preparation thereof characterised by the composition characterised by the carbohydrates used, e.g. polysaccharides
A23G 3/36 - Sweetmeats, confectionery or marzipanProcesses for the preparation thereof characterised by the composition
A23G 3/48 - Sweetmeats, confectionery or marzipanProcesses for the preparation thereof characterised by the composition containing plants or parts thereof, e.g. fruits, seeds, extracts
A61K 9/00 - Medicinal preparations characterised by special physical form
The present invention relates to the use of collagen hydrolysate in the prevention and/or treatment of food craving. The collagen hydrolysate may have a therapeutic and/or non- therapeutic effect. The prevention and/or treatment of craving by the collagen hydrolysate may find purpose in losing bodyweight or improving general well-being. The collagen hydrolysate is preferably administered as a daily food supplement formulation.
The present invention relates to methacryloyl-gelatin and acryloyl-gelatin with low pyrogenic activity, in particular with low lipopolysaccharide content. The (meth)acryloyl-gelatin is further characterized by low (meth)acrylic acid content. The invention further relates to methods for preparing said (meth)acryloyl-gelatin, which do not require a dialysis step. The invention further relates to hydrogels comprising this (meth)acryloyl-gelatin, as well as uses thereof for tissue-engineering applications, and as bio-ink or bio-resin.
2nn-COOH wherein n is an integer form 1 to 10 and further having a lipopolysaccharide content of less than 100 EU/g as well as a method for its preparation using an N-hydroxysuccinimide ester of the substituted cross-linkable carboxylic acid.
innerinner of the filling composition upon deposition is at most 45°C, and wherein the viscosity of the filling composition upon deposition ranges between 500 and 30000 mPa.s. The invention further provides seamless centre filled gummy comprising an active ingredient, which may be produced by the inventive method.
A61K 9/68 - Medicinal preparations characterised by special physical form chewing gum type
A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A61K 36/48 - Fabaceae or Leguminosae (Pea or Legume family)CaesalpiniaceaeMimosaceaePapilionaceae
A61P 11/04 - Drugs for disorders of the respiratory system for throat disorders
A23G 3/34 - Sweetmeats, confectionery or marzipanProcesses for the preparation thereof
A23G 3/44 - Sweetmeats, confectionery or marzipanProcesses for the preparation thereof characterised by the composition containing peptides or proteins
A23G 3/54 - Composite products, e.g. layered, coated, filled
The present invention relates to methacryloyl-gelatin and acryloyl-gelatin with low pyrogenic activity, in particular with low lipopolysaccharide content. The (meth)acryloyl-gelatin is further characterized by low (meth)acrylic acid content. The invention further relates to methods for preparing said (meth)acryloyl-gelatin, which do not require a dialysis step. The invention further relates to hydrogels comprising this (meth)acryloyl-gelatin, as well as uses thereof for tissue- engineering applications, and as bio-ink or bio-resin.
Described is an improved method of removing lipopolysaccharide from an aqueous medium comprising gelatin and lipopolysaccharides, the method comprising the steps of providing an aqueous medium comprising gelatin and lipopolysaccharides, adding to the aqueous medium a micelle-forming surfactant, contacting the medium with a solid adsorbent, separating the solid adsorbent of from the medium and recovering the aqueous medium comprising the gelatin, wherein the method is performed at conditions below the cloud point of the surfactant.
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
C08L 5/00 - Compositions of polysaccharides or of their derivatives not provided for in group or
C08L 89/06 - Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
C07K 1/34 - ExtractionSeparationPurification by filtration, ultrafiltration or reverse osmosis
Described is an improved method of removing lipopolysaccharide from an aqueous medium comprising gelatin and lipopolysaccharides, said method comprising the steps of providing an aqueous medium comprising gelatin and lipopolysaccharides, adding to the aqueous medium a micelle-forming surfactant, contacting the medium with a solid adsorbent, separating the solid adsorbent of from the medium and recovering the aqueous medium comprising the gelatin, wherein the method is performed at conditions below the cloud point of the surfactant.
The present invention relates to methacryloyl-gelatin and acryloyl-gelatin with low pyrogenic activity, in particular with low lipopolysaccharide content. The (meth)acryloyl-gelatin is further characterized by low (meth)acrylic acid content. The invention further relates to methods for preparing said (meth)acryloyl-gelatin, which do not require a dialysis step. The invention further relates to hydrogels comprising this (meth)acryloyl-gelatin, as well as uses thereof for tissue- engineering applications, and as bio-ink or bio-resin.
patents
