Abstract

The present invention relates to use of C1Q and/or a subunit thereof as a target in the prevention and treatment of psoriasis. The C1QA/B/C gene expression in monocytes/macrophages in psoriatic skin lesions is enhanced, the content of C1Q subunit protein in the serum of psoriasis patients exhibits a significant difference before and after treatment, and the expression level of C1Q subunit protein in the serum of psoriasis patients after treatment is significantly reduced. In addition, the C1Q gene knockout can effectively reduce the expression of psoriasis-related inflammatory factors such as IFN-gamma and TNF in C1Q gene-knockout monocytes, indicating that by inhibiting the expression or function of C1Q, the immune response and inflammation level in psoriasis patients can be regulated, thus achieving effective prophylactic and therapeutic effects on psoriasis. Therefore, C1Q can be used as a biological treatment target for psoriasis to prepare a medicament for the prevention and treatment of psoriasis.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61P 37/02 - Immunomodulators
• A61P 17/06 - Antipsoriatics

Abstract

Provided are a medicinal and edible homologous tea beverage for relieving summer-heat and eliminating dampness, a preparation method therefor, and use thereof. The medicinal and edible homologous tea beverage is prepared from the following starting materials in parts by weight: 3-20 parts of agastache rugosus, 2-20 parts of elsholtzia ciliata, 5-30 parts of codonopsis pilosula, and 1-15 parts of tangerine peel. The tea beverage can dispel summer-heat and relieve the exterior syndrome, resolve dampness through its aromatic properties, and regulate qi and strengthen the middle energizer, thereby ameliorating or alleviating heatstroke symptoms in subjects.

IPC Classes  ?

• A61K 36/752 - Citrus, e.g. lime, orange or lemon
• A61K 36/532 - Agastache, e.g. giant hyssop
• A61K 36/53 - Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• A61K 36/344 - Codonopsis
• A23F 3/34 - Tea substitutes, e.g. mateExtracts or infusions thereof
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

A traditional Chinese medicine composition for replenishing qi and enhancing immunity in children, a preparation method therefor, and use thereof. The traditional Chinese medicine composition comprises the following raw materials: 5-10 parts by weight of Codonopsis radix, 10-20 parts by weight of Ficus hirta, 10-20 parts by weight of Poria, 10-20 parts by weight of Hordei germinatus fructus, and 10-20 parts by weight of Mume fructus. Codonopsis radix, as a monarch drug, and Ficus hirta, as a minister drug, cooperate to invigorate the spleen, replenish qi, and regulate the immune function of the body. Moreover, Poria, Hordei germinatus fructus, and Mume fructus are used to invigorate the spleen, promote digestion, and nourish yin. The traditional Chinese medicine composition can ameliorate clinical symptoms in pediatric patients with recurrent respiratory tract infection.

IPC Classes  ?

• A61K 36/8998 - Hordeum (barley)
• A61K 36/344 - Codonopsis
• A61K 9/08 - Solutions
• A61K 9/14 - Particulate form, e.g. powders
• A61P 1/14 - Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• A61P 37/04 - Immunostimulants
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 11/04 - Drugs for disorders of the respiratory system for throat disorders
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A23L 31/00 - Edible extracts or preparations of fungiPreparation or treatment thereof

Abstract

A spleen-invigorating and dampness-eliminating medicinal and edible homologous composition, and a preparation method therefor and use thereof. The medicinal and edible homologous composition comprises the following raw material components in parts by mass: 3-30 parts of Codonopsis pilosula, 5-40 parts of lotus seeds, 10-40 parts of coix seeds, 10-40 parts of Gordon Euryale seeds, 1-15 parts of dried tangerine peels, and 5-30 parts of wolfberry. Aiming at individuals with spleen deficiency accompanied by dampness, whose main manifestations comprise being overweight, heaviness in the hands, feet, head, or body, bland or astringent taste in the mouth, loose or watery stools, etc., the method of syndrome differentiation and treatment in Traditional Chinese Medicine is adopted to invigorate the spleen and eliminate dampness, while also astringing the intestines to stop diarrhea. Moreover, the composition also takes into account the congenital foundation by regulating kidney yang. The composition can effectively ameliorate symptoms, such as being overweight, heaviness in the hands, feet, head, or body, bland or astringent taste in the mouth, loose or watery stools, etc., in individuals with spleen deficiency accompanied by dampness.

IPC Classes  ?

• A61K 36/8994 - Coix (Job's tears)
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
• A61K 36/344 - Codonopsis
• A61P 1/14 - Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The present invention belongs to the field of traditional Chinese medicines, and particularly relates to Leixihaokang, a preparation method therefor, and use thereof. The Leixihaokang of the present invention is prepared from the following active pharmaceutical ingredients in parts by weight: 10 parts of Tripterygium glycosides and 0.1-1.3 parts of Artemisia annua extract. According to the present invention, animal experiments prove that the Leixihaokang can ameliorate renal damage in nephrotic syndrome caused by adriamycin, reduce the occurrence of proteinuria, and reduce the apoptosis of renal tissue cells. Meanwhile, the Leixihaokang of the present invention has a good inhibitory effect on renal, hepatic, splenic, and cardiac toxicity in the treatment process of nephrotic syndrome. According to the present invention, animal experiments also prove that the Leixihaokang can ameliorate skin injury in imiquimod-induced psoriasis, reduce inflammatory infiltration and alleviate skin damage. Meanwhile, the Leixihaokang has a certain degree of inhibitory effect on the hepatic and reproductive system toxicity in the treatment process of psoriasis.

IPC Classes  ?

• A61K 36/37 - Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
• A61K 36/282 - Artemisia, e.g. wormwood or sagebrush
• A61K 31/585 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
• A61P 17/06 - Antipsoriatics
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

A 2-aryl-2,3,4,5-tetrahydro-1,4-epoxybenzazepine compound having a structural formula as represented by formula I and the use thereof in the preparation of an anti-tumor drug. The 2-aryl-2,3,4,5-tetrahydro-1,4-epoxybenzazepine compound has good tumor cell proliferation inhibition activity against at least one among a human lung cancer cell A549, a human colon cancer cell HCT116, a human liver cancer cell HepG2, and a human breast cancer cell MCF-7.

IPC Classes  ?

• C07D 498/08 - Bridged systems
• A61K 31/537 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
• A61P 35/00 - Antineoplastic agents

Abstract

A medicated diet composition for treating a heat cough, prepared from the raw materials in the following parts by mass: 50-100 parts of kumquat, 30-50 parts of Eleocharis dulcis, 5-10 parts of Glehniae radix and 5-10 parts of Platycodonis radix. The medicated diet composition can improve the symptoms of a heat cough of a SARS-CoV-2 infection.

IPC Classes  ?

• A61K 36/89 - Cyperaceae (Sedge family)
• A61K 36/75 - Rutaceae (Rue family)
• A61K 36/34 - Campanulaceae (Bellflower family)
• A61K 36/23 - Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
• A61P 11/14 - Antitussive agents
• A61P 31/14 - Antivirals for RNA viruses
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives

Abstract

The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a medicated diet composition for treating a cold cough, and a preparation method therefor and the use thereof. The medicated diet composition of the present invention comprises the raw materials in the following parts by mass: 50-100 parts of kumquat, 10-20 parts of fresh ginger, 2-3 parts of Citri reticulatae pericarpium and 5-10 parts of Platycodonis radix. The medicated diet composition of the present invention can quickly improve the symptoms of a cold cough of a SARS-CoV-2 infection, and is particularly suitable for patients with a cold cough of a SARS-CoV-2 infection in regions where drug resources are relatively short, medical resources are relatively poor and the purchase of drugs is relatively difficult.

IPC Classes  ?

• A61K 36/9068 - Zingiber, e.g. garden ginger
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A61P 11/14 - Antitussive agents
• A61P 31/14 - Antivirals for RNA viruses
• A61P 11/04 - Drugs for disorders of the respiratory system for throat disorders
• A61P 11/10 - Expectorants

Abstract

Provided are a traditional Chinese medicine composition for tonifying Qi, activating blood and detoxificating and use thereof. The composition is prepared from the following ingredients: 10-30 parts of sun-dried ginseng, 6-30 parts of pseudo-ginseng, and 3-15 parts of Rheum officinale. The traditional Chinese medicine composition can ameliorate the illness state of patients suffering from sepsis secondary to pulmonary infection, and the oxygen saturation of the patients is improved by means of bowel-relaxing and anti-inflammation effects, thus shortening the mechanical ventilation time of the patients.

IPC Classes  ?

• A61K 36/708 - Rheum (rhubarb)
• A61K 36/258 - Panax (ginseng)
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 31/04 - Antibacterial agents

Abstract

Disclosed in the present invention is a new triptolide derivative as shown in formula (I). Also disclosed in the present invention are a preparation method for the compound and the medical use thereof in preparation of anti-cancer drugs. Triptolide acrylate of the present invention and a pharmaceutically acceptable salt thereof have anti-cancer activity, and after animal in-vivo experiments, can effectively inhibit tumor growth in animals. A plurality of in-vitro experiments proves that same can significantly increase the protein expression quantity of p53, promote the apoptosis of tumor cells, effectively inhibit the growth of the tumor cells, and have the effect of inhibiting metastasis of cancer cells. More importantly, the toxicity of the compound to normal cells is less than that of triptolide.

IPC Classes  ?

• A61K 31/365 - Lactones
• A61P 35/00 - Antineoplastic agents
• C07J 73/00 - Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms

Abstract

A traditional Chinese medicine for the treatment of diabetic nephropathy, comprising the following raw materials in parts by weight: 9-30 parts of radix astragali, 6-15 parts of semen cuscutae, 5-10 parts of peach kernel, 3-10 parts of rhizoma atractylodis, 3-10 parts of dried tangerine peel, 15-30 parts of centella asiatica, and 3-10 parts of cordyceps cicadae.

IPC Classes  ?

• A61K 36/752 - Citrus, e.g. lime, orange or lemon
• A61K 35/64 - Insects, e.g. bees, wasps or fleas
• A61P 37/02 - Immunomodulators
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention belongs to the field of traditional Chinese medicine, and in particular, to a composition for preventing rheumatoid arthritis, a preparation method therefor, and an application thereof. The composition for preventing rheumatoid arthritis of the present invention is prepared from the following raw material components in parts by mass: 15-60 parts of raw Semen Coicis, 5-30 parts of Radix Angelicae Sinensis, 5-30 parts of Radix Paeoniae Alba, 1-15 parts of Herba Ephedrae, 5-30 parts of Ramulus Cinnamomi, 5-30 parts of Radix Glycyrrhizae Praeparata, 5-30 parts of Rhizoma Atractylodis, and 10-60 parts of Radix Astragali. Proved by a CIA rat model experiment, the composition for preventing rheumatoid arthritis of the present invention can obviously alleviate the joint swelling degree of a CIA rat, X ray shows that bone destruction can be improved, and a pathological section shows good effects of inhibiting synovial tissue proliferation, reducing inflammatory cell infiltration, and delaying bone and cartilage destruction, thereby achieving the effects of symptom improvement, bone protection and anti-inflammatory for the CIA rat.

IPC Classes  ?

• A61K 36/8994 - Coix (Job's tears)
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

A composition for preventing and/or treating rheumatoid arthritis, a preparation method therefor, and an application thereof. The composition is made from the following raw material components in parts by mass: 10-40 parts of Radix Salviae Miltiorrhizae, 15-120 parts of Rhizoma Dioscoreae Nipponicae, 15-60 parts of Radix Astragali, 5-30 parts of Radix Paeoniae Alba, 3-15 parts of Ephedra, 3-15 parts of Radix Aconiti Laterailis Prepareata, 5-30 parts of Morinda Officinalis, and 5-30 parts of honey-fried licorice root. By means of clinical tests, it is proven that said composition can alleviate the symptoms of articulation swelling and suffered by patients, control the level of inflammation and disease progression, and has potential bone protection effects.

IPC Classes  ?

• A61K 36/8945 - Dioscorea, e.g. yam, Chinese yam or water yam
• A61K 36/746 - Morinda
• A61K 36/714 - Aconitum (monkshood)
• A61K 36/71 - Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
• A61K 36/65 - Paeoniaceae (Peony family), e.g. Chinese peony
• A61K 36/537 - Salvia (sage)
• A61K 36/484 - Glycyrrhiza (licorice)
• A61K 36/481 - Astragalus (milkvetch)
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Abstract

The present invention belongs to the field of traditional Chinese medicines, and in particular relates to a composition for preventing and/or treating rheumatoid arthritis, a preparation method therefor and an application thereof. The composition for preventing and/or treating rheumatoid arthritis of the present invention is prepared from the following raw material components in parts by mass: 5-30 parts Notopterygium root, 5-45 parts kadsura pepper stem, 3-20 parts of prepared aconite root, 5-30 parts of Gentiana macrophylla, 5-30 parts of ramulus mori, 5-30 parts of Angelica sinensis, 5-20 parts of Ligusticum wallichii, 3-15 parts of Costustoot, and 3-30 parts of Radix glycyrrhizae preparata. According to clinical trials, the composition for preventing and/or treating rheumatoid arthritis of the present invention can improve the symptoms of joint swelling and pain in patients, control inflammation levels and disease progression, and has potential bone protection effects.

IPC Classes  ?

• A61K 36/714 - Aconitum (monkshood)
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

Disclosed in the present invention is an application of a glutaminase inhibitor in preparation of a drug for treating psoriasis. According to the present invention, in-vitro cell experiments prove that the glutaminase inhibitor can inhibit keratinocyte metabolism glutamine, inhibit miR-31 induced up-regulated keratinocyte mitochondrial respiration, inhibit miR-31 induced mTOR pathway, reduce cell activity and promote cell apoptosis, and has an anti-inflammatory effect; animal experiments prove that the glutaminase inhibitor can be used for effectively treating imiquimod-induced mouse psoriasis-like pathology change, comprising remarkably reducing a Baker score of a skin lesion, effectively reducing an epidermal hypertrophy degree, remarkably reducing the number of subepidermal capillaries, remarkably reducing the number of epidermal Ki67 positive cells and reducing the expression of epidermal GLS. Therefore, the glutaminase inhibitor can be used for preparing a drug for treating psoriasis.

IPC Classes  ?

• A61K 31/42 - Oxazoles
• A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
• A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61K 31/433 - Thiadiazoles
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 17/06 - Antipsoriatics

Abstract

Disclosed in the present invention is a new triptolide derivative as shown in formula (I). Also disclosed in the present invention are a preparation method for the compound and the medical use thereof in the preparation of anti-cancer drugs. The triptolide acrylate of the present invention and pharmaceutically acceptable salts thereof have anti-cancer activity, and after animal in-vivo experiments, can effectively inhibit tumor growth in animals. A plurality of in-vitro experiments prove that same can significantly increase the protein expression quantity of p53, promote the apoptosis of tumor cells, effectively inhibit the growth of the tumor cells, and have the effect of inhibiting cancer cell metastasis. More importantly, the toxicity of the compound to normal cells is less than that of triptolide.

IPC Classes  ?

• C07D 493/22 - Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
• C07J 73/00 - Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
• A61K 31/365 - Lactones
• A61P 35/00 - Antineoplastic agents

Abstract

Applications of psoralen in preparing an Nrf2 inhibitor, a medicament for Nrf2 inhibition-related diseases, and an anticancer medicament. Psoralen reduces the level of Nrf2 protein expression, reduces the antioxidative stress ability of human non-small cell lung carcinoma A549 cells, and increases the proapoptotic effects of chemotherapeutic medicament cisplatin with respect to A549. Psoralen has no significant impact on animal liver and kidneys when used as a medicament.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 33/243 - PlatinumCompounds thereof
• A61P 35/00 - Antineoplastic agents