Abstract

Provided is amniotic fluid and/or an extract thereof from non-human animals, especially birds and non-human mammals, for inhibiting a cytokine storm and preventing and treating cytokine storm syndrome.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• A61K 35/57 - BirdsMaterials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61P 9/00 - Drugs for disorders of the cardiovascular system

Abstract

A drug used for treating ischemia and hypoxia-induced tissue necrosis or for improving cardiac function; the drug contains amniotic fluid from a non-human animal and/or an extract thereof, and an optional pharmaceutically acceptable carrier, wherein the amniotic fluid comes from chicken eggs having an embryonic age of 5-12 days, eggs from other birds corresponding to the described developmental period, embryos from rodents having a gestational age of 8-20 days, or embryos from other non-human mammals corresponding to the described developmental period. The drug may promote the growth of human umbilical vein endothelial cells, AC16 cells and chicken embryo fibroblasts, improve cardiac function after myocardial infarction, and promote cardiac cell regeneration after a myocardial infarction.

IPC Classes  ?

• A61K 35/57 - BirdsMaterials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/08 - Solutions
• A61K 35/50 - PlacentaPlacental stem cellsAmniotic fluidAmnionAmniotic stem cells
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 9/04 - Inotropic agents, i.e. stimulants of cardiac contractionDrugs for heart failure

Abstract

A method and composition for promoting cell growth and tissue repair, relating a use of amniotic fluid from non-human animals, especially birds and non-human mammals, and/or an extract thereof. The composition may be a cell culture medium containing the amniotic fluid and/or the extract thereof, or may be a pharmaceutical composition.

IPC Classes  ?

• A61K 35/57 - BirdsMaterials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

An extract of the amniotic fluid of a non-human animal, the octanol/water partition coefficient Log P of the active component contained in the extract being within the range of 0.05-1.897. The active component obtained by isolation has cell proliferation activity and/or promotes heart function recovery after a myocardial infarction.

IPC Classes  ?

• A61K 35/50 - PlacentaPlacental stem cellsAmniotic fluidAmnionAmniotic stem cells
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 9/00 - Drugs for disorders of the cardiovascular system

Abstract

A method and composition for promoting cell growth and tissue repair, relating a use of amniotic fluid from non-human animals, especially birds and non-human mammals, and/or an extract thereof. The composition may be a cell culture medium containing the amniotic fluid and/or the extract thereof, or may be a pharmaceutical composition.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

A drug used for treating ischemia and hypoxia-induced tissue necrosis or for improving cardiac function; the drug contains amniotic fluid from a non-human animal and/or an extract thereof, and an optional pharmaceutically acceptable carrier, wherein the amniotic fluid comes from chicken eggs having an embryonic age of 5-12 days, eggs from other birds corresponding to the described developmental period, embryos from rodents having a gestational age of 8-20 days, or embryos from other non-human mammals corresponding to the described developmental period. The drug may promote the growth of human umbilical vein endothelial cells, AC16 cells and chicken embryo fibroblasts, improve cardiac function after myocardial infarction, and promote cardiac cell regeneration after a myocardial infarction.

IPC Classes  ?

• A61K 35/57 - BirdsMaterials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 9/10 - DispersionsEmulsions
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A method for purifying active substances in non-human animal amniotic fluid, the method comprising a step of separating a neutral fraction having a molecular weight of 500-1200 Daltons from amniotic fluid. Further provided is an extract, the extract being a neutral fraction having a molecular weight of 500-1200 Daltons, wherein the extract may promote cell proliferation.

IPC Classes  ?

• C07K 1/18 - Ion-exchange chromatography