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Found results for
 patents
1.
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USE OF P-BENZOQUINONE AND/OR DERIVATIVE THEREOF IN PREPARATION OF ANTI NOVEL-CORONAVIRUS DRUG
| Application Number |
CN2021114452 |
| Publication Number |
2023/019614 |
| Status |
In Force |
| Filing Date |
2021-08-25 |
| Publication Date |
2023-02-23 |
| Owner |
- SHANDONG DYNE MARINE BIOPHARMACEUTICAL CO., LTD. (China)
- BEIJING DYNE HIGH-TECH PEDIATRIC PHARMACEUTICAL R&D INSTITUTE CO., LTD (China)
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| Inventor |
- Yan, Shiqiang
- Yang, Jie
- He, Shuwang
- Wang, Wensheng
- Cheng, Zhongwei
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Abstract
Use of p-benzoquinone and/or a derivative thereof in the preparation of an anti novel-coronavirus drug, which belongs to the technical field of biomedicine. The p-benzoquinone and/or the derivative thereof can inhibit the activity of 3C-like protease (3CLP) and/or papain-like cysteine protease (PLP) of a novel coronavirus, thereby inhibiting the activity and proliferation of a novel coronavirus and alleviating the immune imbalance in infected host cells, so that the effect of treating a novel coronavirus is achieved.
IPC Classes ?
- A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K 31/277 - NitrilesIsonitriles having a ring, e.g. verapamil
- A61P 31/14 - Antivirals for RNA viruses
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2.
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LYCORINE β-ARYL ACRYLATE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
| Application Number |
CN2021111332 |
| Publication Number |
2023/000398 |
| Status |
In Force |
| Filing Date |
2021-08-06 |
| Publication Date |
2023-01-26 |
| Owner |
SHANDONG DYNE MARINE BIOPHARMACEUTICAL CO., LTD (China)
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| Inventor |
- Yan, Shiqiang
- Wang, Peng
- Cao, Huanying
- Yang, Jie
- He, Shuwang
- Wang, Wensheng
- Jing, Yajun
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Abstract
6-123-101-61-61-61-62-62-63-63-6 cycloalkyl and phenyl. The lycorine β-aryl acrylate derivative has a good antitumor activity and also has good medicinal prospects.
IPC Classes ?
- C07D 491/16 - Peri-condensed systems
- A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
- A61P 35/00 - Antineoplastic agents
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3.
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Lycorine derivative, and pharmaceutical composition and use thereof
| Application Number |
17056533 |
| Grant Number |
11932653 |
| Status |
In Force |
| Filing Date |
2018-07-27 |
| First Publication Date |
2021-07-08 |
| Grant Date |
2024-03-19 |
| Owner |
- SHANDONG DYNE MARINE BIOPHARMACEUTICAL CO., LTD (China)
- BEIJING DYNE HIGH-TECH PEDIATRIC PHARMACEUTICAL R&D INSTITUTE CO., LTD. (China)
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| Inventor |
- Pan, Xiandao
- Yang, Yajun
- Shen, Longying
- Zheng, Wensheng
- He, Shuwang
- Yan, Shiqiang
- Jing, Yajun
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Abstract
The present invention relates to the technical field of medicine, and particularly to a lycorine derivative of Formula (I), and a pharmaceutically acceptable salt, a preparation method, a pharmaceutical composition and use thereof. The lycorine derivative has obvious antiviral activity and is useful in the treatment of viral diseases such as hand-foot-mouth disease.
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4.
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LYCORINE DERIVATIVES, PHARMACEUTICAL COMPOSITE THEREOF AND USAGE THEREFOR
| Application Number |
CN2018097678 |
| Publication Number |
2020/019357 |
| Status |
In Force |
| Filing Date |
2018-07-27 |
| Publication Date |
2020-01-30 |
| Owner |
SHANDONG DYNE MARINE BIOPHARMACEUTICAL CO., LTD (China)
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| Inventor |
- Pan, Xiandao
- Yang, Yajun
- Shen, Longying
- Zheng, Wensheng
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Abstract
The present invention belongs to the field of medicine and relates to a type of lycorine derivatives as shown in formula (I), a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition thereof and an application therefor. The lycorine derivatives feature distinct antiviral activity, and may be used for the treatment of viral diseases, such as hand-foot-and-mouth disease.
IPC Classes ?
- C07D 491/16 - Peri-condensed systems
- A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
- A61P 31/12 - Antivirals
- A61P 31/14 - Antivirals for RNA viruses
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