Abstract

The present invention relates to a method for refining a dabigatran crude product. The method is refining a dabigatran crude product by means of acetone/water, and then refining same using ethyl acetate to obtain refined dabigatran. The method features high dabigatran crude product refining yield, high product purity and a small number of refinements, can reduce the use amount of a solvent and improve working efficiency, and is prone to be industrialized.

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Disclosed in the present invention is a ceramic film cleaning and sterilizing process method for use in intelligent cleaning and production of fermented cordyceps sinensis powder (Cs-4), comprising the following steps: 1) flushing: at the time of ending the filtering of ceramic films, circularly flushing a group of ceramic films with a flushing solution, and during flushing, using a clear solution filtered by the ceramic films as a backflushing solution to backflush the group of ceramic films; 2) pickling: using an acidic cleaning agent to circularly perform pickling on the ceramic films, and during pickling, using a clear solution filtered by the ceramic films as a backflushing solution to backflush the group of ceramic films; 3) alkaline washing: using an alkaline cleaning agent to circularly perform alkaline washing on the ceramic films, and during alkaline washing, using a clear solution filtered by the ceramic films as a backflushing solution to backflush the group of ceramic films; 4) rinsing with soft water: using soft water as a rinsing agent to circularly rinse the ceramic films, and during rinsing, using a clear solution filtered by the ceramic films as a backflushing solution to backflush the group of ceramic films; 5) sterilization: using a sterilizing agent solution to circularly sterilize the ceramic films, and during circular sterilization, using a clear solution filtered by the ceramic films as a backflushing solution to backflush the group of ceramic films; and 6) rinsing with purified water.

IPC Classes  ?

• B01D 65/02 - Membrane cleaning or sterilisation

Abstract

A preparation method for fermented Cordyceps sinensis powder Cs-4 decoction pieces. Said method comprises the following steps: cultivating a strain to obtain a qualified mycelium liquid, collecting the qualified mycelium liquid, filtering and blow-drying same to obtain mycelia, drying the blow-dried mycelia using a double-cone dryer, preparing the dried mycelia into pills, drying the pills in an oven, and crushing, mixing and packaging same to obtain the Cordyceps sinensis powder Cs-4 decoction pieces. The method performs slow multiple drying on the mycelia, and thus well protects the medicinal ingredients in the fermented Cordyceps sinensis powder, and improves the medicinal value of the fermented Cordyceps sinensis powder. In addition, the fermented Cordyceps sinensis powder Cs-4 decoction pieces prepared by the present method have good color and luster, have good fragrance, and are convenient to carry and use.

IPC Classes  ?

• A61K 36/068 - Cordyceps
• C12N 1/14 - Fungi Culture media therefor
• C12R 1/645 - Fungi

Abstract

A culture medium for Paecilomyces hepiali Cs-4 and a preparation method therefor, comprising a seed culture medium and a liquid fermentation culture medium, the components of the seed culture medium being glucose, peptone, wheat bran, inorganic salt, and amino acids, and the components of the liquid fermentation culture medium being hot-pressed soybean cake powder, glucose, sucrose, inorganic salt, amino acids, vitamin B1, adenine, and Panax notoginseng. The preparation method for the culture medium is simple and suitable for industrial production. Using a different culture medium at different stages is beneficial for the growth of the strain. The addition of amino acids, vitamin B1, and adenine to the culture medium enables the vigorous growth of the Cs-4 mycelium, and the content of adenosine, total amino acids, ergosterol, and mannitol in the prepared Cordyceps sinensis powder is high. After being added to the culture medium, the Panax notoginseng can be used by the strain, and notoginsenoside and ginsenoside can be detected in the powder; the content of the original active ingredients in the strain powder is also increased, significantly increasing the medicinal value of the Cordyceps sinensis powder.

IPC Classes  ?

• C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
• C12N 1/14 - Fungi Culture media therefor
• C12R 1/79 - Paecilomyces

Abstract

11, the seed tank culture medium contains purines, the breeding tank culture medium contains purines and pyrimidines, and the fermentor culture medium contains purines and pyrimidines, and the fungus powder obtained from the cultures has a high content of nucleosides.

IPC Classes  ?

• C12N 1/14 - Fungi Culture media therefor
• C12N 1/38 - Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factorsStimulation of growth by removal of a chemical compound
• C12R 1/79 - Paecilomyces