Disclosed herein are alkenyl-terminated tetraarylmetalloporphyrin compounds comprising an ethylene glycol unit, a preparation method therefor, and use thereof. The preparation method for the alkenyl-terminated tetraarylmetalloporphyrin compound I-M comprising the ethylene glycol unit comprises: reacting a compound I with a divalent metal acetate to prepare the compound I-M. The compounds of the present invention have excellent dissolution performance, and can effectively block more than 40% of harmful blue light while hardly absorbing beneficial blue light. Due to the use of chemical bonding instead of a coating or dissolving manner, the properties are stable, and precipitation cannot occur after long-term use. Various blue light-blocking materials can be prepared by means of polymerization with different monomers.
C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
C08F 220/20 - Esters of polyhydric alcohols or phenols
C08F 230/04 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal
C08F 230/08 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing silicon
C08F 220/32 - Esters containing oxygen in addition to the carboxy oxygen containing epoxy radicals
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
Disclosed is a tetraaryl porphyrin compound containing an enoic acid ester. The compound has excellent high-energy short-wave blue light absorption characteristics and thermal stability, can also be used as a cross-linking agent due to containing four C=C bonds at the terminus of the structure, and can be polymerized with other monomers by means of chemical bonding to form a spatial network structure, and therefore has the advantages of effectively crosslinking polymer materials and enhancing material stability. The polymer material prepared by adding only 0.05% of this compound can effectively filter out harmful blue light of 385-445 nm (the average transmittance is less than 60%), and has, especially for high-energy short-wave blue light of 400-420 nm, an average transmittance of less than 50%, without affecting the beneficial blue light of 446-505 nm (the transmittance is close to 100%); moreover, the compound does not show a yellow color, does not cause color display distortion, and can achieve a better harmful blue light filtering effect in the case of a very small amount of addition. By adjusting the amount of addition, the compound can be used for selective filtering of blue light of different bands and different intensities in different fields.
C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
C08L 101/00 - Compositions of unspecified macromolecular compounds
A mono-end-capped amphipathic organosiloxane macromonomer, capable of being well intermixed with different hydrophilic monomers without a solvent and being used for preparing a highly oxygen-permeable and highly hydrophilic silicone hydrogel material. Also provided is a silicone hydrogel, prepared by the mono-end-capped amphipathic organosiloxane macromonomer and the following components by means of polymerization reaction: 5-60 parts of a mono-end-capped amphipathic organosiloxane macromonomer, 0-30 parts of a small molecular silicon monomer, 10-70 parts of a hydrophilic monomer, an initiator, and a cross-linking agent. The silicone hydrogel has a good hydrophilic property, a high light transmission property, and a high oxygen-permeable property. Further provided is a corneal contact lens, made of the silicone hydrogel material, and having the advantages of good oxygen permeability and light transmittance, strong hydrophilicity, and wearing comfort, and the like.
C08F 230/08 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing silicon
C08F 220/28 - Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
C08F 226/02 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
C08F 222/14 - Esters having no free carboxylic acid groups
Disclosed is a singly terminated organosiloxane macromonomer, which intermixes effectively with various hydrophilic monomers when there is no solvent for dissolution, and can be used for preparing a silicone hydrogel material with high oxygen permeability and high hydrophilicity. Further provided is a silicone hydrogel, which is prepared by means of a polymerization reaction of the singly terminated organosiloxane macromonomer and the following components: 5-60 parts of the singly terminated organosiloxane macromonomer, 0-30 parts of a micromolecular silicon monomer, 10-70 parts of a hydrophilic monomer, and an initiator and a cross-linking agent. The silicone hydrogel has good hydrophilic performance, good light transmittance performance and high oxygen permeability. In addition, further provided is a contact lens, which is made of the silicone hydrogel material, and has the advantages of good oxygen permeability, good light transmittance performance, strong hydrophilicity, being comfortable for wearing, etc.
C08F 230/08 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing silicon
C08F 220/32 - Esters containing oxygen in addition to the carboxy oxygen containing epoxy radicals
C08F 220/20 - Esters of polyhydric alcohols or phenols
Disclosed are a surface silicon-hydrogen functionalized silicone rubber material, and a preparation, hydrophilic treatment and application method. A silicone rubber material with low lipid absorption can be directly prepared. The surface silicon-hydrogen functionalized silicone rubber material is formed by reacting the following components in parts by weight: 30-60 parts of vinyl silicone oil, 1-20 parts of silicon rubber inhibitor, 0.5-1 part of catalyst, and 30-60 parts of hydrogen-based silicone oil.
A method for the surface hydrophilic modification of silicon rubber, comprising: step 10) preparing a silicon rubber substrate: mixing vinyl polysiloxane, hydroxy polysiloxane and a polyvinyl monomer well, then adding a catalyst, and forming a mixture; injecting the mixture into a mold for thermal curing, and preparing a silicon rubber substrate for which a surface contains double bonds; step 20) preparing a solution containing a hydrophilic monomer: dissolving the hydrophilic monomer having double bonds, a cross-linking agent and a photoinitiator into an organic solvent, and obtaining a solution containing the hydrophilic monomer; step 30) performing surface hydrophilic modification of the silicon rubber: placing the silicon rubber substrate into the solution prepared in step 20), placing under ultraviolet light, removing after ultraviolet initiation, washing with water, and obtaining hydrophilically modified silicon rubber. In the method, a hydrophilic layer is connected to a silicon rubber main body by means of a chemical bond, which may significantly reduce the contact angle of the silicon rubber material, and improve the hydrophilicity thereof and improve the biocompatibility thereof.
A corneal contact lens nursing composition containing trehalose quaternary ammonium salt comprises the following components by weight percentage: trehalose quaternary ammonium salt of 0.001-2%, isotonic regulator of 0.01-2%, surfactant of 0.05-2%, complexing agent of 0.01-1%, buffer of 0.01-3%, antimicrobial compound of 0.00001-1% and water of 89-99.91899%. The composition is used for storing, sterilizing, cleaning, lubricating, and hydrating corneal contact lenses, has a drought resistant function, is effective for relieving dryness and stiffness of eyes, can reduce a death rate of corneal epithelial cells in a dry environment, and promotes repairing of corneal epithelial and endothelial cells. A kill rate of each composition to escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is greater than 99.9%, and a kill rate to candida albicans and solanaceae fusarium is greater than 90.0%.
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