Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
In Chemical Formula 1 above,
n is an integer of 1 to 6,
X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3− and —SO3H,
R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, substituted or unsubstituted C8-20 alkyl, —(CH2)m1SO3−, —(CH2)m2SO3H, and
Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
In Chemical Formula 1 above,
n is an integer of 1 to 6,
X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3− and —SO3H,
R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, substituted or unsubstituted C8-20 alkyl, —(CH2)m1SO3−, —(CH2)m2SO3H, and
m1 is an integer of 1 to 7,
m2 is an integer of 1 to 7,
p1 is an integer of 1 to 10,
q1 is an integer of 0 to 10,
r1 is an integer of 1 to 10, and
Y1 is selected from H, —OH, halogen and
Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
In Chemical Formula 1 above,
n is an integer of 1 to 6,
X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3− and —SO3H,
R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, substituted or unsubstituted C8-20 alkyl, —(CH2)m1SO3−, —(CH2)m2SO3H, and
m1 is an integer of 1 to 7,
m2 is an integer of 1 to 7,
p1 is an integer of 1 to 10,
q1 is an integer of 0 to 10,
r1 is an integer of 1 to 10, and
Y1 is selected from H, —OH, halogen and
o1 is an integer of 1 to 10.
G01N 33/533 - Production of labelled immunochemicals with fluorescent label
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
Provided is a portable isothermal amplification device for amplifying a nucleic acid using an isothermal amplification method, the device comprising: a tube insertion part into which a PCR tube is to be inserted, which is provided in an upper portion of the portable isothermal amplification device; a cover for covering the tube insertion part; a storage space for accommodating a heating device and a storage space cover for blocking the storage space from an outside, which is provided in a lower portion of the portable isothermal amplification device; and a heat insulator for blocking heat from the outside and a heat-sensing sticker capable of measuring a temperature of heat generated by the heating device, which is provided inside the storage space.
B01L 7/00 - Heating or cooling apparatusHeat insulating devices
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Reagents for scientific or medical research use; Chemical reagents for scientific or experimental use; Reagents for analyzing nucleic acids for scientific or experimental purposes; Chemical reagents for scientific use; Reagents for biotechnological use; Reagents for dyeing cells, namely, reagents for scientific purposes; Reagents for research purposes; Chemical reagents for genetic research purposes; Reagents for chemical analysis, namely, reagents for scientific purposes; Magnetic particles in fluid form for scientific or industrial use; Magnetic particles in fluid form for separating nucleic acids and proteins; Magnetic particles in fluid form for coloring and marking particular molecules
4.
FLUORESCENT COMPOUND FOR DETECTING BIOLOGICAL MATERIAL AND PREPARATION METHOD THEREOF
Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
In Chemical Formula 1 above,
X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3− and SO3H,
R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, C8-18 alkyl, —(CH2)mSO3−, —(CH2)mSO3H, and
Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
In Chemical Formula 1 above,
X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3− and SO3H,
R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, C8-18 alkyl, —(CH2)mSO3−, —(CH2)mSO3H, and
R3 and R4 are the same as or different from each other and each independently selected from C1-7 alkyl, —(CH2)mCOOZ and
Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
In Chemical Formula 1 above,
X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3− and SO3H,
R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, C8-18 alkyl, —(CH2)mSO3−, —(CH2)mSO3H, and
R3 and R4 are the same as or different from each other and each independently selected from C1-7 alkyl, —(CH2)mCOOZ and
R3 and R4 are simultaneously not any one selected from —(CH2)mCOOZ and
Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:
In Chemical Formula 1 above,
X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3− and SO3H,
R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, C8-18 alkyl, —(CH2)mSO3−, —(CH2)mSO3H, and
R3 and R4 are the same as or different from each other and each independently selected from C1-7 alkyl, —(CH2)mCOOZ and
R3 and R4 are simultaneously not any one selected from —(CH2)mCOOZ and
Provided is a fluorescent compound for detecting a biomaterial having the following Chemical Formula 1:
Provided is a fluorescent compound for detecting a biomaterial having the following Chemical Formula 1:
Provided is a fluorescent compound for detecting a biomaterial having the following Chemical Formula 1:
In Chemical Formula 1 above,
R1 and R5 are the same as or different from each other, and each independently selected from H, —SO3- and SO3H,
R2 and R6 are the same as each other or each independently selected from hydrogen or methyl
R4 and R8 are the same as or different from each other, and each independently selected from H, —SO3- and (CH2)SO3H,
R3 and R4 can form alkylene chain with arbituary-substituted 3 carbons combined with the nitrogen atom attached with R3,
R7 and R8 can form alkylene chain with arbituary-substituted 3 carbons combined with the nitrogen atom attached with R7,
when R8 and R8 do not form alkylene chain, R6, R7 and R8 are hydrogen at the same time and the nitrogen atom attached with R6 and R7 at the same time forms double bond with the carbon of mother molecule and has positive charge.
G01N 33/533 - Production of labelled immunochemicals with fluorescent label
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 491/153 - Ortho-condensed systems the condensed system containing two rings with oxygen as ring hetero atom and one ring with nitrogen as ring hetero atom
6.
Fluorescent compound with cyanuric-hydroxide and preparation method thereof
A fluorescent compound in accordance with exemplary embodiments of the present invention has high stability under a water-soluble condition to be easily stored for a long time and improve pH stability and can be more efficiently used for labeling and dyeing of a target material by introducing the triazine substituted with a hydroxyl group as a linker to improve the fluorescent intensity even at a low concentration as compared with the conventional structure. Further, the fluorescent compound is excellent in optical stability and exhibits stable fluorescence in long-term dyeing, and is excellent in fluorescence intensity while being not accumulated in the body, and thus, can be easily dyed and imaged in vivo even in the use of a small amount as compared with the conventional dyes to be economically used.
C09B 23/06 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups three CH groups, e.g. carbocyanines
C09B 23/08 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups more than three CH groups, e.g. polycarbocyanines
C09B 23/10 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an even number of CH groups
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
7.
Fluorescent composition for detecting biological material
Disclosed is a fluorescent composition for whole blood analysis capable of predicting the diagnosis, treatment and prognosis of diseases through blood analysis. In the case of using the fluorescent composition of exemplary embodiments of the present invention for whole blood analysis, the shape of a target material such as red blood cells and white blood cells may be maintained as it is and non-target biomaterials and the like may be dissolved to increase the sensitivity and affinity to the target and improve the staining efficiency of the blood cell nucleic acids, thereby increasing the fluorescent efficiency. Therefore, more accurate blood cell analysis is possible than conventional techniques, and through this, it is possible to accurately predict not only the diagnosis of the disease, but also the treatment method and prognosis.
Staphylococcus aureus (MRSA) in a specimen, and a method for determining the infection with MRSA using the diagnostic kit is performed by visually observing a color change after LAMP reaction, and the color change is caused by a change in a magnesium concentration and confirmed using a specific dye compound which sensitively reacts with magnesium ions. The amplification of the MRSA DNA is performed using the loop-mediated isothermal amplification (LAMP), so that the diagnostic kit has advantages of being conveniently used anytime and anywhere and quickly diagnosing.
The novel intercalating fluorescent compounds of exemplary embodiments of the present invention for analyzing nucleic acids, etc. have excellent intercalating efficiency with nucleic acids such as DNA and RNA of biomaterials, and may not only continuously maintain fluorescence properties and efficiency, but also have excellent effects even in terms of storage stability such as temperature and moisture, etc. and biosafety. In addition, the fluorescent compounds have various advantages capable of being dissolved in distilled water, which is a solvent harmless to the human body, and being applied to a wide range of analysis without being limited to the analysis of specific cells and living tissues.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C09B 23/06 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups three CH groups, e.g. carbocyanines
C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
StaphylococcusStaphylococcus aureus (MRSA). A method of determining an infection of MRSA by using the diagnostic kit is performed by observing a change of color after a loop-mediated isothermal amplification (LAMP) reaction, and the change of color is caused by a change in magnesium concentration and may be confirmed by using a specific dye compound developed in the present invention which is sensitive to magnesium ions. According to the present invention, since amplification of MRSA DNA uses an LAMP method, the diagnostic kit provided in the present invention can be conveniently used anytime and anywhere and also enables quick diagnosis.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH
