The present invention relates to a pharmaceutical composition comprising a compound selected from the group consisting of elafibranor, 2-[2,6-dimethyl-4-[3-[4-(methylthio)phenyl]- 3-oxo-propyl]phenoxy]-2-methylpropanoic acid (GFT1007), and a pharmaceutically acceptable salt of elafibranor or GFT1007, for use in a method for treating primary biliary cholangitis (PBC) in a subject having PBC with a baseline plasma alkaline phosphatase (ALP) level of more than 1.67xULN and at most 3xULN.
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
2.
METHODS FOR THE SCREENING OF PATIENTS WITH AT-RISK METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS (MASH)
Provided herein is a method for the screening of patients with at-risk MASH (metabolic dysfunction-associated steatohepatitis, formerly named nonalcoholic steatohepatitis or NASH). The combination of levels of five circulating markers, i.e. alanine aminotransferase (ALAT), aspartate transaminase (ASAT), platelets, hsa-miR-34a and YKL-40 in a subject, and eventually the age and gender of said subject, allows to accurately identify non-cirrhotic at-risk MASH. The information obtained from the levels of these markers also allows to screen a subject as being eligible to liver biopsy and/or to classify a subject as a receiver or non-receiver of a treatment of MASH and/or to classify a subject as a responder or non-responder of a treatment of MASH.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
The present invention relates to a pharmaceutical composition comprising a compound selected from the group consisting of elafibranor, 2-[2,6-dimethyl-4-[3-[4-(methylthio)phenyl]-3-oxo-propyl]phenoxy]-2-methylpropanoic acid (GFT1007), and a pharmaceutically acceptable salt of elafibranor or GFT1007, for use in a method for reducing fatigue in subject having primary biliary cholangitis (PBC). The pharmaceutical composition of the invention provides a significative reduction of the PROMIS Fatigue T-score (PROMIS Short Form - Fatigue 7a questionnaire (V1.0)) from baseline in a subject having PBC.
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 43/00 - Drugs for specific purposes, not provided for in groups
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Compilation of medical reports. Scientific research for medical purposes; pharmaceutical
research and development services; conducting of clinical
trials for determining the efficacy and safety of
pharmaceutical products in the treatment of acute liver
decompensation and acute-on-chronic liver failure (ACLF);
conducting scientific studies and analyses; providing
information, results and data relating to scientific or
medical research and development of pharmaceutical products,
especially from an online searchable database; clinical
trials; pharmaceutical and biological development and
research services for third parties; clinical research;
evaluation of the efficacy of pharmaceutical products;
clinical development services. Advisory services relating to health [medical] care; medical
information; medical information services provided via the
Internet; medical diagnosis services.
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Scientific research for medical purposes; pharmaceutical
research and development services; conducting clinical
trials to determine the efficacy and safety of
pharmaceutical products in the treatment of decompensated
liver disease, acute-on-chronic liver failure (ACLF);
conducting scientific studies and analyses; providing
information, results and data relating to scientific or
medical research and development of pharmaceutical products,
especially from an online searchable database; clinical
trials; pharmaceutical and biological development and
research services for third parties; clinical research;
evaluation of the efficacy of pharmaceutical products;
clinical development services. Advisory services relating to health [medical] care; medical
information; compilation of medical reports [medical
information]; medical information services provided via the
Internet; medical diagnosis services.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Scientific research for medical purposes in the field of pharmaceuticals; pharmaceutical research and development services; Scientific research in the nature of conducting clinical trials to determine the efficacy and safety of pharmaceutical products in the treatment of decompensated liver disease, acute-on-chronic liver failure (ACLF); conducting scientific feasibility studies, including analysis; providing information, including results and data, relating to scientific or medical research in the field of pharmaceuticals and development of pharmaceutical products, especially from an online searchable database; Scientific research in the nature of conducting clinical trials for others; pharmaceutical and biological development and research services for third parties; clinical research in the field of hepatic, metabolic, gastrointestinal and oncological diseases and disorders; evaluation of the efficacy of pharmaceutical products; Scientific research in the nature of clinical development services. Advisory services relating to health being medical care; medical information; Providing medical information, namely, compilation of medical reports; medical information services provided via the Internet; medical diagnosis services.
8.
NON-INVASIVE DIAGNOSTIC OF NON-ALCOHOLIC STEATOHEPATITIS
The invention relates to a novel method for the diagnosis of non-alcoholic steatohepatitis (NASH), and for classifying a subject as a potential receiver of a treatment for NASH.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
A61K 31/216 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
C12Q 1/54 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving glucose or galactose
C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
G06F 17/18 - Complex mathematical operations for evaluating statistical data
G16B 25/00 - ICT specially adapted for hybridisationICT specially adapted for gene or protein expression
G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
The present invention relates to a kit for performing multiplex immuno-PCR. The products, compositions, kits and the methods implementing said kits can be advantageously used for the diagnosis of non-alcoholic steatohepatitis (NASH).
C12Q 1/6804 - Nucleic acid analysis using immunogens
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Compilation of medical reports. Scientific research for medical purposes; pharmaceutical research and development services; conducting of clinical trials for determining the efficacy and safety of pharmaceutical products in the treatment of acute liver decompensation and acute-on-chronic liver failure (ACLF); conducting scientific studies and analyses; providing information, results and data relating to scientific or medical research and development of pharmaceutical products, especially from an online searchable database; clinical trials; pharmaceutical and biological development and research services for third parties; clinical research; evaluation of the efficacy of pharmaceutical products; clinical development services. Advisory services relating to health [medical] care; medical information; medical information services provided via the Internet; medical diagnosis services.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Diagnostic preparations for industrial and scientific use;
chemical reagents for industrial use; chemical reagents for
scientific use. Pharmaceutical preparations; diagnostic preparations and
diagnostic biomarker reagents for medical use; diagnostic
testing materials for medical use; blood and blood-derived
samples for medical use. Software; downloadable software applications; scientific
apparatus and instruments for recording, processing,
reproduction and transmission of data; data processing
equipment. Medical apparatus, instruments and equipment; instruments
and tools for medical diagnosis; diagnostic apparatus for
medical use. Scientific and technological services; biological research;
clinical research and medical research; industrial analysis
and industrial research services; design and development of
computer hardware and software; programming for computers;
research laboratory. Medical analysis and medical diagnosis services; medical
analysis of blood samples; assistance services relating to
medicine and health care; medical information; provision of
medical information.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Diagnostic preparations for industrial and scientific use; chemical reagents for industrial use; chemical reagents for scientific use Pharmaceutical preparations for the diagnosis, prevention and treatment of metabolic, hepatic and oncological diseases and disorders; diagnostic preparations and diagnostic biomarker reagents for medical use; medical diagnostic testing materials for medical use namely, diagnostic reagents and assays for testing of bodily fluids; blood and blood-derived samples for medical use, namely, blood substitutes for human use, blood plasma, serum and other blood-derived biological samples Downloadable and recorded software for use in the management of cancer, metabolic diseases and liver diseases, namely, software for creating customized care plans for patients, for managing patient data, for providing clinical decision support information and analytics, for managing patient medications, and for providing reporting and analytics relating to patient care, and for use in research and development of new pharmaceutical products for others, namely, software for managing, analyzing and reporting on clinical trial data; downloadable software applications for use in diagnosing medical conditions; scientific apparatus and instruments for recording, processing, reproduction and transmission of data, namely electronic data loggers and recorders; data processing equipment Medical apparatus, instruments and equipment namely, DNA, RNA and protein analysis apparatus, DNA, RNA and protein quantifiers, medical devices for measuring DNA, RNA, biochemical and physical parameters, namely, concentration of biomarkers and blood analyzers for evaluation of metabolic, hepatic and oncological diseases and disorders; instruments and tools for medical diagnosis, namely diagnostic medical devices for diagnosis of metabolic, hepatic and oncological diseases and disorders, blood analysis apparatus, DNA and RNA analysis apparatus, gene analyzers, medical devices for measuring biochemical and physical parameters, namely, concentration of biomarkers relating to the evaluation of metabolic, hepatic and oncological diseases and disorders, and blood analyzers for evaluation of metabolic, hepatic and oncological diseases and disorders Scientific and technological services, namely research in the medical, biomedical, and chemical fields, for the diagnosis, prevention and treatment of metabolic, hepatic and oncological diseases and disorders; biological research; clinical research and medical research in the field of diagnosis, prevention and treatment of metabolic, hepatic and oncological diseases and disorders; industrial analysis and industrial research services in the field of pharmacy; design and development of computer hardware and software; programming for computers Medical analysis for the diagnosis, prevention and treatment of metabolic, hepatic and oncological diseases and disorders; medical analysis of blood samples; assistance services in the fields of medicine and health care; medical information; provision of medical information
The present invention relates to formulations of elafibranor or a pharmaceutically acceptable salt or ester thereof; and uses thereof. In particular, the present invention relates to an oral solid dosage form comprising at least elafibranor or a pharmaceutically acceptable salt or ester thereof; a filler, a disintegrating agent and a binder.
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present invention relates to a compound selected from nitazoxanide, tizoxanide and tizoxanide glucuronide, for use in a method for the treatment of sepsis in a subject in need thereof.
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
18.
PPAR-AGONISTS FOR USE IN THE TREATMENT OF LIVER FAILURE
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Software; downloadable software applications; scientific
apparatus and instruments particularly for recording,
processing, reproducing, transmitting data; data processing
equipment; downloadable electronic publications; Electronic
databases; all these goods exclusively in the field of liver
and metabolic diseases. Pharmaceutical research (research for the discovery of new
medicines); scientific research, particularly in the
medical, biomedical, chemical field, professional
consultations unrelated to the conduct of business in the
field of scientific research and therapies; research and
development of new pharmaceutical products for others;
scientific research in the field of pharmacy; all these
services exclusively in the field of liver and metabolic
diseases. Medical services; veterinary services; medical assistance;
hospital services; consultation with respect to pharmacy;
all these services exclusively in the field of liver and
metabolic diseases.
20.
USE OF TRANSMEMBRANE PH GRADIENT LIPOSOMES FOR TREATING HYPERAMMONEMIC CRISIS ASSOCIATED WITH INBORN ERRORS OF METABOLISM
The present disclosure provides a use of a liposomal suspension comprising transmembrane pH- gradient liposomes, for the treatment of an acute hyperammonemia episode (HAC) associated with inborn errors of metabolism (IEM) in a subject, wherein the treatment comprises intraperitoneally administering the liposomal suspension to the subject and removing a dialysate containing ammonia-loaded liposomes from the subject.
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one (Elafibranor or GFT505) for treating cholestatic diseases, and more specifically PBC and/or PSC.
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/421 - 1,3-Oxazoles, e.g. pemoline, trimethadione
A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable and recorded software for use in the management of cancer, metabolic diseases and liver diseases, namely, software for creating customized care plans for patients, for managing patient data, for providing clinical decision support information and analytics, for managing patient medications, and for providing reporting and analytics relating to patient care; downloadable and recorded software for use in research and development of new pharmaceutical products for others, namely, software for managing, analyzing and reporting on clinical trial data; downloadable software applications for use in diagnosing medical conditions; scientific apparatus and instruments particularly for recording, processing, reproducing, and transmitting data; data processing equipment; downloadable electronic publications in the nature of brochures, newsletters, reports, medical journals and medical periodicals, in the field of prevention, diagnosis and treatment of cancer, metabolic diseases and liver diseases; downloadable electronic databases in the field of prevention, diagnosis and treatment of cancer, metabolic diseases and liver diseases; all these goods exclusively in the field of liver and metabolic diseases. Pharmaceutical research being research for the discovery of new medicines; scientific research, particularly in the medical, biomedical, and chemical field; consultation in the field of scientific research and development of therapies; research and development of new pharmaceutical products for others; scientific research in the field of pharmacy; all these services exclusively in the field of liver and metabolic diseases. Medical services; veterinary services; medical assistance; hospital services; consultation with respect to pharmacy, namely, pharmaceutical consultation; all these services exclusively in the field of liver and metabolic diseases.
24.
NITAZOXANIDE FOR THE TREATMENT OF HEPATIC IMPAIRMENT
A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
25.
COMBINATION OF SUBSTITUTED 2,4 DIAMINO-QUINOLINE COMPOUNDS AND MEK INHIBITORS FOR USE IN THE TREATMENT OF LIVER CANCERS
The present invention relates to a compound selected from nitazoxanide, tizoxanide, tizoxanide glucuronide and pharmaceutically acceptable salts thereof, for use in a method for the treatment of hepatic impairment.
A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5 -dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one (Elafibranor or GFT505) for treating cholestatic diseases, and more specifically PBC and/or PSC.
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one (Elafibranor or GFT505) for treating cholestatic diseases, and more specifically PBC and/or PSC.
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one (Elafibranor or GFT505) for treating cholestatic diseases, and more specifically PBC and/or PSC.
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one (Elafibranor or GFT505) for treating cholestatic diseases, and more specifically PBC and/or PSC.
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one (Elafibranor or GFT505) for treating cholestatic diseases, and more specifically PBC and/or PSC.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/576 - ImmunoassayBiospecific binding assayMaterials therefor for hepatitis
33.
METHODS FOR DIAGNOSING ADVANCED LIVER FIBROSIS OR LIVER CIRRHOSIS
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/576 - ImmunoassayBiospecific binding assayMaterials therefor for hepatitis
34.
METHODS FOR DIAGNOSING ADVANCED LIVER FIBROSIS OR LIVER CIRRHOSIS
Provided herein is a method of diagnosing or prognosing advanced liver fibrosis or liver cirrhosis in a patient. The method is accomplished by determining a score based on the circulating levels in serum of two markers.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/576 - ImmunoassayBiospecific binding assayMaterials therefor for hepatitis
35.
METHODS FOR DIAGNOSING ADVANCED LIVER FIBROSIS OR LIVER CIRRHOSIS
Provided herein is a method of diagnosing or prognosing advanced liver fibrosis or liver cirrhosis in a patient. The method is accomplished by determining a score based on the circulating levels in serum of three markers.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/576 - ImmunoassayBiospecific binding assayMaterials therefor for hepatitis
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 25/00 - Drugs for disorders of the nervous system
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical, veterinary and sanitary products for medical
use; chemical preparations for medical and pharmaceutical
use or for veterinary use; biological preparations for
medical and pharmaceutical use or for veterinary use; enzyme
preparations for medical and pharmaceutical use or for
veterinary use; cultures of microorganisms for medical,
pharmaceutical or veterinary use; cell preparations for
medical, pharmaceutical or veterinary use, particularly for
gene therapy and cell therapy; diagnostic products for
medical or veterinary use; diagnostic reagents for medical
or veterinary use; dietetic substances for medical use;
dietetic foods for medical use; food supplements. Software; downloadable software applications; scientific
apparatus and instruments particularly for recording,
processing, reproducing, transmitting data; data processing
equipment; downloadable electronic publications; electronic
databases. Pharmaceutical research (research for the discovery of new
medicines); scientific research, particularly in the
medical, biomedical, chemical field, professional
consultations unrelated to the conduct of business in the
field of scientific research and therapies; research and
development of new pharmaceutical products for others;
scientific research in the field of pharmacy. Medical services; veterinary services; medical assistance;
hospital services; consultation with respect to pharmacy.
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one (Elafibranor or GFT505) for treating cholestatic diseases, and more specifically PBC and/or PSC.
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one (Elafibranor or GFT505) for treating cholestatic diseases, and more specifically PBC and/or PSC.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable software for use in prevention, diagnosis, treatment, management and monitoring of metabolic diseases and liver diseases, and in research and development of new pharmaceutical products for others; downloadable software applications for use in diagnosing medical conditions; scientific apparatus and instruments particularly for recording, processing, reproducing, transmitting data; data processing equipment; downloadable electronic publications in the nature of brochures, newsletters, reports, medical publications in the field of prevention, diagnosis and treatment of metabolic diseases and liver diseases; electronic databases for use in prevention, diagnosis and treatment of metabolic diseases and liver diseases recorded on computer media; all these goods exclusively in the field of liver and metabolic diseases Pharmaceutical research being research for the discovery of new medicines; scientific research, particularly in the medical, biomedical, chemical field; professional consultations unrelated to the conduct of business in the field of scientific research and development of therapies; research and development of new pharmaceutical products for others; scientific research in the field of pharmacy Medical services; veterinary services; medical assistance; hospital services; consultation with respect to pharmacy, namely, pharmaceutical consultation
44.
IMPROVED DIAGNOSIS OF NONALCOHOLIC STEATOHEPATITIS
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical and veterinary products, namely, pharmaceutical and veterinary preparations for prevention and treatment of liver diseases, metabolic diseases, gastroenterological diseases, inflammatory diseases, immune disorders and cancers; chemical preparations for medical or pharmaceutical use, namely, chemical reagents for medical or pharmaceutical use, diagnostic preparations for medical use, diagnostic testing agents and substances for medical use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical and veterinary products, namely, pharmaceutical and veterinary preparations for prevention and treatment of liver diseases, metabolic diseases, gastroenterological diseases, inflammatory diseases, immune disorders and cancers; chemical preparations for medical or pharmaceutical use, namely, chemical reagents for medical or pharmaceutical use, diagnostic preparations for medical use, diagnostic testing agents and substances for medical use
49.
COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRIMARY BILIARY CHOLANGITIS
The invention relates to a pharmaceutical composition comprising elafibranor or a pharmaceutically acceptable salt thereof, for use to treat primary biliary cholangitis (PBC) in a subject intolerant to ursodeoxycholic acid (UDCA).
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Scientific research for medical purposes; pharmaceutical
research and development services; conducting clinical
trials to determine the efficacy and safety of
pharmaceutical products in the treatment of acute-on-chronic
liver failure (ACLF); conducting scientific studies and
analyses; providing information, results and data relating
to scientific or medical research and development of
pharmaceutical products, especially from an online
searchable database; clinical trials; pharmaceutical and
biological development and research services for third
parties; clinical research; evaluation of the efficacy of
pharmaceutical products; clinical development services. Advisory services relating to health [medical] care; medical
information; compilation of medical reports [medical
information]; medical information services provided via the
Internet; medical diagnosis services.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Scientific research for medical purposes; pharmaceutical research and development services; scientific research, namely conducting clinical trials for others to determine the efficacy and safety of pharmaceutical products in the treatment of acute-on-chronic liver failure (ACLF); conducting scientific feasibility studies and analyses in the field of pharmaceuticals; providing information, results and data relating to scientific and medical research and development of pharmaceutical products, especially from an online searchable database; medical and scientific research, namely conducting clinical trials for others; pharmaceutical and biological product development and research services for third parties; clinical research in the field of pharmaceuticals; evaluation of the efficacy of pharmaceutical products; clinical development services, namely clinical research consulting in the field of pharmaceuticals Advisory services relating to health care and medical advisory services; providing medical information in the nature of compilation of medical reports; medical information services provided via the Internet; medical diagnosis services in the nature of performing diagnosis of diseases
C07C 323/62 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
56.
TREATMENT OF PRIMARY BILIARY CHOLANGITIS WITH ELAFIBRANOR
The invention relates to a pharmaceutical composition comprising elafibranor, GFT1007 or a pharmaceutically acceptable salt of elafibranor or of GFT1007, for use to treat primary biliary cholangitis (PBC) without provoking and/or worsening at least one adverse event associated to PBC.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
57.
PHOSPHATE DERIVATIVES OF RORGAMMA MODULATORS AND USES THEREOF
The present invention relates to phosphate derivatives of formula (I), and their therapeutic uses, preferably for treating a respiratory disease. The present invention further relates to pharmaceutical compositions and devices comprising such compounds.
C07F 9/6558 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
A61K 9/00 - Medicinal preparations characterised by special physical form
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Diagnostic preparations for industrial and scientific use;
chemical reagents for industrial use; chemical reagents for
scientific use. Pharmaceutical preparations; diagnostic preparations and
diagnostic bio-marking reagents for medical use; diagnostic
testing materials for medical use; blood and blood-derived
samples for medical use. Scientific and technological services; biological research;
clinical research and medical research; industrial analysis
and industrial research services; design and development of
computer hardware and software; programming for computers;
research laboratory. Medical analysis and medical diagnosis services; medical
analysis of blood samples; assistance services relating to
medicine and health care; medical information; provision of
medical information.
59.
METHODS FOR DIAGNOSING AND EVALUATING NON-ALCOHOLIC STEATOHEPATITIS
The invention relates to a method for the diagnosis of non-alcoholic steatohepatitis (NASH), for determining the activity, the stage, or the severity of NASH or for classifying a subject as a potential receiver or non receiver of a treatment of NASH using circulating miRNAs and other blood circulating markers of liver damage, e.g. alpha 2 macroglobulin, HbA1c, N-terminal pro-peptide of collagen type III, miR-34 and miR-200. It also relates to a kit for implementing the method of the invention, and the compounds for use in a method for the treatment of NASH, wherein the subject to be treated is identified, evaluated or classified according to the method of the invention.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/72 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood pigments, e.g. hemoglobin, bilirubin
G01N 33/66 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood sugars, e.g. galactose
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
60.
METHOD FOR NASH RISK ASSESSMENT IN PATIENTS HAVING A METABOLIC DISORDER
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
62.
METHOD FOR NASH RISK ASSESSMENT IN PATIENTS HAVING A METABOLIC DISORDER
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Diagnostic preparations for industrial and scientific use; chemical reagents for industrial use; chemical reagents for scientific use Pharmaceutical preparations for the prevention and treatment of metabolic disorders and liver diseases; diagnostic preparations and diagnostic bio-marking reagents for medical use; diagnostic testing materials for medical use namely, diagnostic reagents and assays for testing of bodily fluids; blood for medical use and blood-derived samples for medical use, namely, blood substitutes for human use, blood plasma Scientific and technological services, namely, scientific research in the field of metabolic disorders and liver diseases; biological research; clinical research namely, scientific research in the field of metabolic disorders and liver diseases and medical research; industrial analysis in the nature of analysis of industrial fluids and industrial research services in the field of pharmaceuticals; design and development of computer hardware and software; computers programming; research laboratory in the nature of laboratory research services relating to pharmaceuticals Medical analysis for the diagnosis and treatment of persons; medical analysis of blood samples; medical assistance services relating to medicine and health care; medical information; provision of medical information
64.
PPAR-AGONISTS FOR USE IN THE TREATMENT OF LIVER FAILURE
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
A61K 31/216 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
65.
ELAFIBRANOR DERIVATIVES AGONISTS OF PPAR FOR USE IN THE TREATMENT OF SEPSIS
The present invention relates to a compound selected from nitazoxanide, tizoxanide and tizoxanide glucuronide, for use in a method for the treatment of sepsis in a subject in need thereof.
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
68.
ELAFIBRANOR AND 2-[2,6-DIMETHYL-4-[3-[4-(METHYLTHIO)PHENYL]-3-OXO-PROPYL] PHENOXY]-2-METHYLPROPANOIC ACID ANALOG AS PPAR-AGONISTS FOR USE IN THE TREATMENT OF SEPSIS
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
69.
PPAR-AGONISTS FOR USE IN THE TREATMENT OF LIVER FAILURE
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/423 - Oxazoles condensed with carbocyclic rings
A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/216 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
70.
ELAFIBRANOR DERIVATIVES AGONISTS OF PPAR FOR USE IN THE TREATMENT OF SEPSIS
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
The present invention relates to a compound selected from nitazoxanide, tizoxanide and tizoxanide glucuronide, for use in a method for the treatment of sepsis in a subject in need thereof.
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
The present invention is directed to novel compositions and methods useful for the quantitative detection of microRNAs. More particularly, it relates to premixes useful in reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) reactions for the detection of miR-34.
The present invention is directed to novel compositions and methods useful for the quantitative detection of microRNAs. More particularly, it relates to premixes useful in reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) reactions for the detection of miR-34.
The present invention is directed to novel compositions and methods useful for the quantitative detection of microRNAs. More particularly, it relates to premixes useful in reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) reactions for the detection of miR-34.
The invention provides an anti-fibrotic or anti-nonalcoholic steatohepatitis (NASH) drug for use in a method for reducing the risk for a subject to develop liver fibrosis or NASH, wherein the drug is administered to a subject classified as at risk to develop liver fibrosis or NASH. The invention further provides an anti-fibrotic or anti-NASH substance for use in a method for the treatment of liver fibrosis or NASH, wherein the drug is administered to a subject having type 2 diabetes.
A61K 31/201 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having one or two double bonds, e.g. oleic or linoleic acid
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
76.
NITAZOXANIDE AND THIAZOLIDES FOR USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH OXIDATIVE STRESS
The present invention relates to the stabilization of micro-RNA molecules. The compositions and methods described herein can advantageously be used for the provision of internal control and standard microRNAs for inclusion into kits, useful for the normalized, relative or absolute quantification of a microRNA in a biological fluid.
The present invention relates to a combination product comprising (i) nitazoxanide (NTZ) or an analogue thereof, and (ii) a PPAR agonist, for use in the treatment of an immune diseases or inflammation.
A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
The present invention relates to a non-invasive method for classifying a subject as a potential receiver or non-receiver of a treatment for non-alcoholic steatohepatitis.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
82.
A METHOD AND A SYSTEM FOR OBTAINING A TRAINING DATASET USABLE FOR TRAINING A NEURAL NETWORK TO DETECT CELLS, USING COLOR DECONVOLUTIONS AND GEOMETRICAL ATTRIBUTES
A system and a method performed by a computer for obtaining a training dataset usable for training a neural network to detect cells, comprising: - obtaining a group of images of slices of tissue marked by immunostaining, - for each image of the group of images, performing (S10) a color deconvolution of the image according to a given color so as to obtain a deconvoluted image, wherein the given color is selected in accordance with at least one dye used during said immunostaining, - for each deconvoluted image, searching (S11) in the deconvoluted image for pixels which verify at least one geometrical condition, and annotating the found pixels as belonging to cells to obtain annotated images each associated with an image of the group of images, the images of the group of images and their associated annotated images forming the training dataset.
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one (Elafibranor or GFT505) for treating cholestatic diseases, and more specifically PBC and/or PSC.
The present invention provides novel compounds that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
87.
COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRIMARY BILIARY CHOLANGITIS
The invention relates to a pharmaceutical composition comprising elafibranor or a pharmaceutically acceptable salt thereof, for use to treat primary biliary cholangitis (PBC) in a subject intolerant to ursodeoxycholic acid (UDCA).
The invention relates to a pharmaceutical composition comprising elafibranor or a pharmaceutically acceptable salt thereof, for use to treat primary biliary cholangitis (PBC) in a subject intolerant to ursodeoxycholic acid (UDCA).
The present invention relates to compositions and methods for preparing in vitro models of non-alcoholic fatty liver disease, and more particularly of liver steatosis and fibrosing non-alcoholic steatohepatitis (NASH).
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Services relating to online service provision, namely
collection of data and information in the field of medical
diagnostics; processing of data and information, especially
in the biological, medical, diagnostic and chemical fields;
collection, processing of data particularly in the
biological, medical, diagnostic and chemical sectors. Dissemination by means of telecommunications, including
electronic telecommunications, of documents to assist in the
diagnosis or treatment with medication of diseases or
pathologies, particularly of the liver. Publishing by any means, including electronic, of documents
to support diagnosis or drug treatment of diseases or
disorders, especially of the liver. Pharmaceutical research (research for the discovery of new
medicines); scientific research, especially in the medical,
biomedical, chemical, genetic, pharmaceutical field; basic
and applied scientific research; research in the diagnostic
field; technical research; sorting and selection of
molecules, namely, scientific work; development and
validation of biological tests, cellular tests and genetic
tests; functional genomics activities for identifying,
characterizing, validating or developing biologically active
molecules, namely, scientific work; analysis of biological
substances in biological fluids; computer programming in the
field of scientific research and for the pharmaceutical
industry; surveying [engineering work]; technical project
study; professional consultancy unrelated to business
dealings in the field of scientific and medical research;
research and development of new pharmaceutical products for
others; scientific research in the field of pharmacy;
electronic storage of data and information, especially in
the biological, medical, diagnostic and chemical fields;
electronic storage of data especially in the biological,
medical, diagnostic and chemical sectors. Medical analysis and medical diagnosis services; medical
analyses of blood samples, biological preparations or
biological fluids; support services in the field of
medicine, health care and pharmaceutical research; medical
information; providing medical information, providing
information and advice in relation to medicines, liver
diseases, their diagnosis or treatment with medication.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Reagents for chemical analyses; reagents for scientific use;
reagents for scientific or medical research; diagnostic
reagents for scientific use; reagents for immunoserology and
molecular diagnosis; chemical reagents for genetic research;
in-vivo diagnostic reagents for scientific use; diagnostic
reagents for scientific use or for research; diagnostic
reagents for in-vitro use in biochemistry, molecular
biology, clinical chemistry and microbiology. Pharmaceuticals for use in human or veterinary medicine, for
scientific use; chemical preparations for use in human or
veterinary medicine, or for pharmaceutical use; biological
preparations for use in human or veterinary medicine, or for
pharmaceutical use; preparations for use in human or
veterinary medicine, or for pharmaceutical use;
microorganism cultures for use in human or veterinary
medicine, or for pharmaceutical use; cell preparations for
use in human or veterinary medicine, or for pharmaceutical
use, in particular for gene therapy and cell therapy; blood,
biological fluids and blood-derived samples for medical use;
diagnostic products for use in human or veterinary medicine;
diagnostic reagents for use in human or veterinary medicine. Software; downloadable software applications; scientific
apparatus and instruments especially for recording,
processing, reproducing, transmitting data; data processing
equipment. Medical apparatus, instruments and equipment; instruments
and tools for medical diagnosis or scientific research;
diagnostic apparatus for medical use. Pharmaceutical research (research for the discovery of new
medicines); scientific research, especially in the medical,
biomedical, chemical, genetic, pharmaceutical field; basic
and applied scientific research; technical research; sorting
and selection of molecules, namely, scientific work;
development and validation of biological tests, cellular
tests and genetic tests; functional genomics activities for
identifying, characterizing, validating or developing
biologically active molecules, namely, scientific work;
analysis of biological substances in biological fluids;
computer programming in the field of scientific research and
for the pharmaceutical industry; surveying [engineering
work]; technical project study; professional consultations
unrelated to business operations in the field of scientific
research. Medical analysis and medical diagnosis services; medical
analyses of blood samples, biological preparations or
biological fluids; support services in the field of
medicine, health care and pharmaceutical research; medical
information; provision of medical information.
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Services relating to online service provision, namely
collection of data and information in the field of medical
diagnostics; processing of data and information, especially
in the biological, medical, diagnostic and chemical fields;
collection and processing of data especially in the
biological, medical, diagnostic and chemical sectors. Telecommunication dissemination of documents to support
diagnosis or drug treatment of diseases or disorders,
especially of the liver. Publishing by any means, including electronic, of documents
to support diagnosis or drug treatment of diseases or
disorders, especially of the liver. Pharmaceutical research (research for the discovery of new
medicines); scientific research, especially in the medical,
biomedical, chemical, genetic, pharmaceutical field; basic
and applied research; research in the diagnostic field;
technical research; scientific and medical research
services, namely, sorting and selecting molecules;
development and validation of biological tests, cellular
tests and genetic tests; activities in functional genomics
for identifying, characterizing, validating or developing
biologically active molecules; analysis of biological
substances in biological fluids; computer programming in
the field of scientific research and for the pharmaceutical
industry; surveying [engineering work]; technical project
study; professional consultancy unrelated to business
dealings in the field of scientific and medical research;
research and development of new pharmaceutical products for
others; scientific research in the field of pharmacy;
pharmaceutical research support services; electronic
storage of data and information, especially in the
biological, medical, diagnostic and chemical fields;
electronic storage of data especially in the biological,
medical, diagnostic and chemical sectors. Medical, healthcare support services; medical information;
provision of information and advice in relation to
medicines, liver diseases, the diagnosis or treatment
thereof.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Reagents for chemical analyses; reagents for scientific
use; reagents for scientific or medical research;
diagnostic reagents for scientific use; reagents for
immunoserology and molecular diagnosis; chemical reagents
for genetic research; in-vivo diagnostic reagents for
scientific use; diagnostic reagents for scientific use or
for research; diagnostic reagents for in-vitro use in
biochemistry, molecular biology, clinical chemistry and
microbiology. Pharmaceuticals for use in human or veterinary medicine, for
scientific use; chemical preparations for use in human or
veterinary medicine, or for pharmaceutical use; biological
preparations for use in human or veterinary medicine, or for
pharmaceutical use; preparations for use in human or
veterinary medicine, or for pharmaceutical use;
microorganism cultures for use in human or veterinary
medicine, or for pharmaceutical use; cell preparations for
use in human or veterinary medicine, or for pharmaceutical
use, in particular for gene therapy and cell therapy;
blood, biological fluids and blood-derived samples for
medical use; diagnostic products for use in human or
veterinary medicine; diagnostic reagents for use in human
or veterinary medicine. Software; downloadable software applications; scientific
apparatus and instruments especially for recording,
processing, reproducing, transmitting data; data processing
equipment. Medical apparatus, instruments and equipment; instruments
and tools for medical diagnosis or scientific research;
diagnostic apparatus for medical use. Pharmaceutical research (research for the discovery of new
medicines); scientific research, especially in the medical,
biomedical, chemical, genetic, pharmaceutical field; basic
and applied research; technical research; sorting and
selection of molecules; development and validation of
biological tests, cellular tests and genetic tests;
activities in functional genomics for identifying,
characterizing, validating or developing biologically active
molecules; analysis of biological substances in biological
fluids; computer programming in the field of scientific
research and for the pharmaceutical industry; surveying
[engineering work]; technical project study; professional
consultancy unrelated to business dealings in the field of
scientific and medical research; research and development
of new pharmaceutical products for others; scientific
research in the field of pharmacy. Medical analysis and medical diagnosis services; medical
analyses of blood samples, biological preparations or
biological fluids; support services in the field of
medicine, health care and pharmaceutical research; medical
information; provision of medical information.
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Dissemination of documents by means of telecommunications, including electronic telecommunications, namely transmission of documents to assist in the diagnosis or treatment with medication of diseases or pathologies, particularly of the liver Business services relating to online service provision, namely, collection of data and information for business purposes in the field of medical diagnostics; processing of data and information, especially in the biological, medical, diagnostic and chemical fields; collection and processing of data for business purposes particularly in the biological, medical, diagnostic and chemical sectors Publishing by any means, including electronic, of documents in the nature of written articles, white pages and journals to support diagnosis or drug treatment of diseases or disorders, especially of the liver Pharmaceutical research, namely research for the discovery of new medicines; scientific research, especially in the medical, biomedical, chemical, genetic, pharmaceutical field; basic and applied scientific research; scientific research in the diagnostic field; technical scientific research; scientific research, namely, sorting and selection of molecules; scientific research services, namely development and validation of biological tests, cellular tests and genetic tests; scientific research services, namely functional genomics activities for identifying, characterizing, validating and developing biologically active molecules; analysis of biological substances in biological fluids; computer programming in the field of scientific research and for the pharmaceutical industry; engineering services, namely surveying technical project study being scientific research; professional consultancy unrelated to business dealings in the field of scientific and medical research; research and development of new pharmaceutical products for others; scientific research in the field of pharmacy; electronic storage of data and information, especially in the biological, medical, diagnostic and chemical fields; electronic storage of data especially in the biological, medical, diagnostic and chemical sectors Medical consultancy services in the field of metabolic disorders and liver diseases and health care consultancy services in the field of metabolic disorders and liver diseases; medical information; providing medical information; providing medical information and advice in relation to medicines, liver diseases, their diagnosis or treatment with medication
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Reagents for chemical analyses for scientific use; reagents for scientific use; reagents for scientific or medical research use; diagnostic reagents for scientific use; reagents for immunoserology and molecular diagnosis for research use; chemical reagents for genetic research; in-vivo diagnostic reagents for scientific use; diagnostic reagents for scientific use or for research use; diagnostic reagents for in-vitro use in biochemistry, molecular biology, clinical chemistry and microbiology for research use; all these goods exclusively in the field of innovative therapeutic and diagnostic solutions in metabolic and liver related diseases; and none of them related to telemedicines services, online medical consultation and online medical assistance provided to the public Pharmaceuticals for use in human or veterinary medicine, for scientific use for the treatment of inflammatory diseases and liver diseases; chemical preparations for use in human or veterinary medicine, or for pharmaceutical use, namely, for the treatment of inflammatory diseases and liver diseases; biological preparations for use in human or veterinary medicine, or for pharmaceutical use, namely, for the treatment of inflammatory diseases and liver diseases; preparations for use in human or veterinary medicine, or for pharmaceutical use, namely, for the treatment of inflammatory diseases and liver diseases; microorganism cultures for use in human or veterinary medicine, or for pharmaceutical use; cell preparations for use in human or veterinary medicine, or for pharmaceutical use, in particular for gene therapy and cell therapy, namely, cell growth media; blood and blood derived samples, namely plasma, serum, platelet free samples for medical use; diagnostic biomarker reagent products for use in human or veterinary medicine; diagnostic reagents for use in human or veterinary medicine; all these goods exclusively in the field of innovative therapeutic and diagnostic solutions in metabolic and liver related diseases; and none of them related to telemedicines services, online medical consultation and online medical assistance provided to the public Downloadable software for use in diagnosis of inflammatory diseases and liver diseases; downloadable software applications for use in diagnosing medical conditions; scientific apparatus and instruments especially for recording, processing, reproducing, transmitting data, namely, electronic data loggers and recorders; data processing equipment; all these goods exclusively in the field of innovative therapeutic and diagnostic solutions in metabolic and liver related diseases; and none of them related to telemedicines services, online medical consultation and online medical assistance provided to the public Medical apparatus, instruments and equipment, namely, DNA, RNA and protein analysis apparatus, DNA, RNA and protein quantifiers, medical devices for measuring DNA, RNA, biochemical and physical parameters, namely concentration of biomarkers relating to the evaluation of inflammatory and liver diseases and blood analyzers for evaluation of inflammatory and liver diseases; instruments and tools for medical diagnosis, namely, computer displays and computer monitors and controllers therefor used in direct association with medical diagnosis apparatus during the process of diagnosis of a condition in an individual; diagnostic apparatus for medical use, namely, medical diagnostic apparatus for testing the biomarker levels; all these goods exclusively in the field of innovative therapeutic and diagnostic solutions in metabolic and liver related diseases; and none of them related to telemedicines services, online medical consultation and online medical assistance provided to the public Pharmaceutical research, namely, research for the discovery of new medicines; scientific research, especially in the medical, biomedical, chemical, genetic, pharmaceutical field; basic and applied scientific research; technical scientific research; scientific research, namely, sorting and selection of molecules; scientific research services, namely, development and validation of biological tests, cellular tests and genetic tests; scientific research, namely, functional genomics for identifying, characterizing, validating and developing biologically active molecules; analysis of biological substances in biological fluids; computer programming in the field of scientific research and for the pharmaceutical industry; engineering services, namely, surveying; technical project study being scientific research; professional consultancy unrelated to business dealings in the field of scientific and medical research; research and development of new pharmaceutical products for others; scientific research in the field of pharmacy; all these services exclusively in the field of innovative therapeutic and diagnostic solutions in metabolic and liver related diseases; and none of them related to telemedicines services, online medical consultation and online medical assistance provided to the public Medical analysis relating to the diagnosis and treatment of persons and medical diagnosis services in inflammatory diseases and liver diseases; medical analyses of blood samples, biological preparations and biological fluids relating to the diagnosis and treatment of persons; support services in the field of medicine, health care and pharmaceutical research, namely, medical analysis for the diagnosis and treatment of patients; medical information; provision of medical information; all these services exclusively in the field of innovative therapeutic and diagnostic solutions in metabolic and liver related diseases; and none of them related to telemedicines services, online medical consultation and online medical assistance provided to the public
100.
ELAFIBRANOR FOR THE TREATMENT OF PRIMARY SCLEROSING CHOLANGITIS
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
