A method for continuous production of tablets, including providing a contained module comprising at least two inlets, at least one mixing unit, at least one analytical sensor, a tablet press, and at least one outlet for tablets, feeding an active pharmaceutical ingredient (API) to one of the at least two inlets, feeding an excipient to the other of the at least two inlets, mixing the material stream comprising the API and the excipient in the at least one mixing unit, measuring parameters of the contents of the material stream with the at least one analytical sensor upstream of the tablet press, controlling the two inlets and/or the mixing unit in response to the parameters measured, continuously supplying the tablet press with the material stream, controlling the speed of the tablet press in response to the parameters measured upstream of the tablet press, and discharging tablets at the at least one outlet.
A61J 3/10 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
B30B 11/00 - Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses or tabletting presses
B29B 7/48 - MixingKneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
B29B 13/06 - Conditioning or physical treatment of the material to be shaped by drying
B29C 43/02 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles
B29C 43/34 - Feeding the material to the mould or the compression means
The contained module (1) comprises inlets for an active pharmaceutical ingredient (API) and for an excipient. The inlets are in fluid communication with at least one mixing unit (41,46), and the outlet of the tablet press (6) is in fluid communication with the releasable outlet port for tablets. The material stream comprising the API and the excipient is mixed in the mixing units. During operation parameters of the contents of the material stream are measured with one or more analytical sensors upstream of the tablet press. The speed of the tablet press is controlled in response to the parameters measured upstream of the tablet press. The finished tablets are discharged at an outlet of the tablet press (6).
B29C 43/08 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles using movable moulds continuously movable with circular movement
A61J 3/10 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
B30B 11/00 - Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses or tabletting presses
B29B 7/48 - MixingKneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
B29B 13/06 - Conditioning or physical treatment of the material to be shaped by drying
B29C 43/02 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles
B29C 43/34 - Feeding the material to the mould or the compression means
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Valves for machines, namely, flow-control valves, metering valves, shut-off valves, outlet valves and stop slide valves for the transport of bulk materials and liquid goods from one container to another or from a container to a processing machine in the food industry, pharmaceutical industry and chemical industry; valve systems comprised primarily of valves for machines, namely, flow-control valves, metering valves, shut-off valves, outlet valves and stop slide valves for the transport of bulk materials and liquid goods from one container to another or from a container to a processing machine in the food industry, pharmaceutical industry and chemical industry; clutches for machines, namely, leakage-free clutches with quick acting closure for flexible containers to be docked on to processing machines for the transport of bulk solids and liquid goods in the food industry, pharmaceutical and chemical industry; clutch systems consisting of clutches for machines; machines for handling and discharge of bulk materials and liquid goods from one container to another or from a container to a processing machine in the food, pharmaceutical and chemical industry; valves for controlling and regulating the flow of gases or liquids not being parts of plumbing, heating, cooling installations or machines, namely, flow-control valves, metering valves, shut-off valves, outlet valves and stop slide valves for the transport of bulk materials and liquid goods from one container to another or from a container to a processing machine in the food industry, pharmaceutical industry and chemical industry; valve systems comprised primarily of valves for controlling and regulating the flow of gases or liquids not being parts of plumbing, heating, cooling installations or machines, namely, flow-control valves, metering valves, shut-off valves, outlet valves and stop slide valves for the transport of bulk materials and liquid goods from one container to another or from a container to a processing machine in the food industry, pharmaceutical industry and chemical industry.
Valves, namely, flow-control valves, metering valves,
shut-off valves, outlet valves and stop slide valves; valves
for the transport of bulk materials and liquid goods from
one container to another or from a container to a processing
machine in the food industry, pharmaceutical industry and
chemical industry; valve systems comprised primarily of
flow-control valves, metering valves, shut-off valves,
outlet valves and stop slide valves, valves for the
transport of bulk materials and liquid goods from one
container to another or from a container to a processing
machine in the food industry, pharmaceutical industry and
chemical industry; clutches, namely leakage-free clutches
with quick acting closure for flexible containers to be
docked on to processing machines for the transport of bulk
solids and liquid goods in the food industry, pharmaceutical
and chemical industry; clutch systems consisting of the
aforementioned clutches; parts and components for the
aforementioned goods; machines for handling and discharge of
bulk materials and liquid goods from one container to
another or from a container to a processing machine in the
food, pharmaceutical and chemical industry.
09 - Scientific and electric apparatus and instruments
Goods & Services
Valves for machines, namely, flow-control valves, metering valves, shut-off valves, outlet valves and stop slide valves for the transport of bulk materials and liquid goods from one container to another or from a container to a processing machine in the food industry, pharmaceutical industry and chemical industry; valve systems comprised primarily of valves for machines, namely, flow-control valves, metering valves, shut-off valves, outlet valves and stop slide valves for the transport of bulk materials and liquid goods from one container to another or from a container to a processing machine in the food industry, pharmaceutical industry and chemical industry; clutches for machines, namely, leakage-free clutches with quick acting closure for flexible containers to be docked on to processing machines for the transport of bulk solids and liquid goods in the food industry, pharmaceutical and chemical industry; clutch systems consisting of clutches for machines; machines for handling and discharge of bulk materials and liquid goods from one container to another or from a container to a processing machine in the food, pharmaceutical and chemical industry Valves for controlling and regulating the flow of gases or liquids not being parts of plumbing, heating, cooling installations or machines, namely, flow-control valves, metering valves, shut-off valves, outlet valves and stop slide valves for the transport of bulk materials and liquid goods from one container to another or from a container to a processing machine in the food industry, pharmaceutical industry and chemical industry; valve systems comprised primarily of valves for controlling and regulating the flow of gases or liquids not being parts of plumbing, heating, cooling installations or machines, namely, flow-control valves, metering valves, shut-off valves, outlet valves and stop slide valves for the transport of bulk materials and liquid goods from one container to another or from a container to a processing machine in the food industry, pharmaceutical industry and chemical industry
A fluid bed apparatus for coating solid particles. The apparatus includes a housing having upwardly extending walls surrounding a perforated base plate, a nozzle for atomizing a coating liquid, the nozzle being provided in the upwardly extending walls, and a device for providing fluidisation gas through the perforations of the base plate for the maintenance of a fluidised layer. The coating liquid nozzle is provided in a channel for co-current introduction of a dispersion gas, the channel debouching into the fluid bed through an orifice having a radius of 5 mm or more. The apparatus provides for the production of particles having smooth surfaces, high yield and a low tendency to form agglomerates.
B05C 19/02 - Apparatus specially adapted for applying particulate materials to surfaces using fluidised-bed technique
B01J 2/00 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic
B01J 8/22 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with fluidised particles with liquid as a fluidising medium gas being introduced into the liquid
B01J 2/16 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
(1) Machines using superheated steam, namely flash dryer machines, ring dryer machines, rotary dryer machines, fluid bed machines, all the aforementioned for the chemical industry, the biotechnology industry, the bio fuel industry, the agri-food industry, the mineral industry, the fertilizer industry, the polymer industry, the power generation industry, the biomass industry, and the pharmaceutical industry.
(2) Drying apparatuses using superheated steam, namely flash dryers, ring dryers, rotary dryers, fluid bed dryers, all the aforementioned for the chemical industry, the biotechnology industry, the bio fuel industry, the agri-food industry, the mineral industry, the fertilizer industry, the polymer industry, the power generation industry, the biomass industry, and the pharmaceutical industry.
Mixing machines, granulation machines, extrusion machines, machines for production of spherical pellets and pelletization machines, all for use in the pharmaceutical field
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Particle form processing machinery; machinery for the production of pharmaceutical products in solid dosage form; machinery for the processing and granulation of food and chemical products; high shear granulators; fluid bed processors; fluid bed processors used for coating; machinery used to produce pellets; extruders; machines to dry pharmaceutical products in solid dosage form; machines to dry food and chemical products in granular and pellet form; spray dryer granulators; fluid bed processors used for drying. Custom manufacturing machines for the processing, granulating, coating and drying of pharmaceutical, food and chemical products. Technical services for particle processing for the pharmaceutical, biotech, food and chemical industries; designing manufacturing process and machines for the processing, granulating, coating and drying of pharmaceutical, food and chemical products.
Machines, namely machines for the chemical industry, machines for the food industry, machines for the drinks industry, machines for the pharmaceutical industry, filling machines, machines for handling, in particular for delivering media in liquid and/or powder form, valves, in particular flow control valves, dosage dispensing valves, cut-off valves, washout valves, stop valves; valves for the transport of bulk material and liquid goods in the food, pharmaceutical and chemical industries; valve systems; parts and fittings for the aforesaid goods.
