A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
The present invention relates to a closing element for a fluid line, preferably a fluid line of a concentrate container, comprising a main body configured to at least partially receive the fluid line, a closing portion configured to be arranged on an open portion of the fluid line to close the fluid line, wherein the closing portion comprises a plurality of plates arranged around a common center point and each separated from another over an intended breaking point, an a pressure receiving portion configured to receive pressure applied by a pressure exertion element, preferably a connector element to be fluidically connected to the fluid line by breaking the intended breaking point, wherein the pressure receiving portion is formed by that part of the plurality of plates projecting outwards from the closing portion or the main body.
The present disclosure relates to a system for predicting the magnitude of ultrafiltration volume expected in a peritoneal dialysis treatment for an individual patient, the system comprising: - a peritoneal treatment machine configured to perform cycles of a peritoneal treatment performed on the patient according to a prescription by controlling at least one actuator and/or valve of the peritoneal treatment machine, the cycles comprising a fill phase, a dwell phase and a drain phase, - a sensor for repeatedly measuring a sensed value during the treatment performed on the patient, - a controller programmed to predict the magnitude of ultrafiltration volume expected during a treatment performed according to a prescription based on a model of ultrafiltration, and to fit parameter values of the model to the individual patient based on the values measured by the sensor,wherein the model of ultrafiltration uses a patient-specific aggregated reflection coefficient as a parameter representing the overall average effect of different pores of the peritoneum and of different solutes present in the peritoneal cavity and the blood plasma on the differential crystalloid osmotic pressure between the peritoneal cavity and blood plasma.
FRESENIUS MEDICAL CARE DEUTSCHLAND, GMBH (Germany)
Inventor
Maheshwari, Vaibhav
Chamney, Paul
Eberle, Bernd
Abstract
Apparatuses comprising at least one processor and a memory coupled to the at least one processor, wherein the memory comprises instructions that when executed by the processor cause the processor to access prescription information for a peritoneal dialysis (RD) process for a patient and provide the prescription information as input to at least one computational model to determine a predicted intraperitoneal volume (IPV) or a predicted ultrafiltration volume (UFV) respectively, wherein the computational model is trained to determine the predicted IPV or UFV respectively based on the prescription information and patient information for at least one RD process cycle for the patient or a population of patients associated with the patient.
The present invention relates to a control device (150) for a blood treatment device (100), wherein the control device (150) is programmed to be in signal connection with a data memory (500) for unidirectional or bidirectional transfer of first data (D1). The control device (150) is further programmed to control or regulate the blood treatment device (100) based on a plurality of sequences of control or regulation commands contained in the first data (D1) after the first data (D1) has been transmitted to the control device (150) from or out of the data memory (500). The control device (150) is further programmed to be in signal connection with a central unit (ZE) not present on or in the blood treatment device (100), e.g. a cloud or a network. The signal connection is used for unidirectional or bidirectional transfer of second data (D2), and for receiving second data (D2) from the central unit (ZE). The control device (150) is further programmed to allocate first data (D1) to the received second data (D2) according to predefined rules and to load this data from the data memory (500) and to control or regulate the operation of the blood treatment device (100) on the basis of this data.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
6.
DEVICE AND METHOD FOR STORING REAL-TIME DATA OF A CRITICALITY PROCEDURE
The invention relates to a method, a real-time device, a computer program, and a computer-readable data carrier for storing real-time data relating to a criticality procedure, so that in case of error the integrity, authenticity, and availability of the stored real-time data are ensured.
G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance
G06F 12/0804 - Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches with main memory updating
7.
METHOD AND DEVICE FOR MONITORING BLOOD PURIFICATION WITH AN EXTRACORPOREAL BLOOD PURIFICATION DEVICE
The invention relates to a method and a device for monitoring blood purification using an extracorporeal blood purification device designed so that blood purification with specified treatment parameters Qb is performed in an extracorporeal blood circuit 9 by means of a blood purification unit 1. A parameter K that is characteristic for the purification performance of the blood purification unit 1 is determined on the basis of the measured concentration of a substance. This parameter K is compared with an expected value K ref . To this end, the computing and/or evaluation unit 25 determines a tolerance range for the expected value, wherein specified actions are triggered by the computing and/or evaluation unit 25 depending on whether the parameter that is characteristic for the purification performance of the blood purification unit is within or outside of the tolerance range for the expected value.
The invention relates to a hollow-fibre membrane filter for purifying liquids, said membrane filter having improved separation properties and comprising: a cylindrical housing; first inflow or outflow chambers and second inflow or outflow chambers surrounding a first and a second end portion, respectively, of the cylindrical housing, the hollow-fibre membrane filter having an aspect ratio of the effective length of the hollow-fibre membranes and the inner diameter of the cylindrical housing so as to improve the inflow of a liquid to the hollow-fibre membranes inside the cylindrical housing.
The invention relates to a hollow-fibre membrane filter for purifying liquids, said membrane filter having improved separation properties and comprising: a cylindrical housing; first inflow or outflow chambers and second inflow or outflow chambers surrounding a first and a second end portion, respectively, of the cylindrical housing, the cylindrical housing being designed in at least one end region so as to improve the inflow of a liquid to the hollow-fibre membranes inside the cylindrical housing.
The invention relates to a method for controlling a blood treatment device (100) in the event of air bubbles or air pockets being present in an extracorporeal blood circuit (300) connected to the blood treatment device (100), which bubbles or pockets have been detected by an air bubble detector (315). The invention also relates to an open or closed-loop control device (150) and to a blood treatment device (100) for carrying out the method according to the invention, to a digital storage medium, a computer program product and a computer program.
The invention relates to a device and a method for producing a hollow fibre membrane bundle consisting of hollow fibre membranes, wherein, in the claimed device, a sheaf of hollow fibre membranes is received in a lower semitubular shell and bundled together to form a hollow fibre membrane bundle by a complementary upper semitubular shell.
The invention relates to a filter device for the exchange of substances, comprising a pipe section-shaped housing with a center of gravity and with two housing ends, in which housing a hollow fiber bundle consisting of semi-permeable membranes is arranged, comprising, furthermore, an end cap having a first and second opening, wherein the housing and the end cap configure a first sealing surface which connects the housing and the end cap sealingly, and wherein the first sealing surface is spaced apart further from the center of gravity of the housing than the aperture, and wherein a first fluid chamber is formed between the first sealing surface and the first opening of the end cap, via which first fluid chamber the first opening is connected to the first flow chamber, wherein the housing and the one end cap configure a second sealing surface, wherein the first and second sealing surface are not configured by way of a sealant.
The present invention relates to a method for analyzing a measured pressure value, including providing a blood treatment apparatus (100), connectible to a blood tube set (300) that has an arterial blood-conducting line (301) and a venous blood-conducting line (305), the blood treatment apparatus (100) further comprising a blood pump (101), pressure gauge (PS1, PS3) for measuring the pressure in the blood-conducting lines (301, 305), while establishing at least one measured pressure value (Pax, Pvx) in each line, an alarm emitting device (500) for emitting an alarm on the basis of the measured pressure value (Pax, Pvx), and a controller (150) for open-loop or closed-loop control of the blood pump (101). The invention further comprises the step of providing an alarm criterion memory (550) for defining what is an event triggering an alarm, and of providing a reference data memory (555). The method further comprises analysis steps, such as measuring prevailing pressures, analyzing the established measured pressure values using alarm criteria, and repeating pressure measurement steps at certain delivery rates of the blood pump (101) in order to analyze, on the basis of the reference data memory, whether there is a false alarm. The method optionally comprises the step of emitting the alarm. The present invention also relates to devices for initiating or carrying out the method. (Fig. 3)
FRESENIUS MEDICAL CARE DEUTSCHLAND, GMBH (Germany)
Inventor
Muller, Stefan
Thys, Martin
Abstract
The invention relates to a medical apparatus designed to receive a detachable fluid-conducting first line portion (3). The medical apparatus comprises a second line portion (2) designed to be connected to the first line portion (3), wherein a movable element (38) is situated in the second line portion (2), by means of which movable element the second line portion (2) is separated into a first sub-portion (2a) and a second sub-portion (2b). In addition, the medical device comprises: at least a first and a second blocking element (7, 8) for enclosing a fluid volume in the first line portion (3) and the second line portion (2); and a pump (6) for generating a vacuum in a first of the two sub-portions (2a, 2b) of the second line portion (2), as a result of which elastic deformation takes place in and/or on the second of the two sub-portions (2a, 2b) and the movable element (38) is moved; and a controller for controlling the pump (6), wherein the controller is programmed, in a disconnection mode, to operate the pump (6) to generate the vacuum.
A medical system, comprising: a medical machine; and a gateway device configured to communicate with the medical machine to allow access to a network, the gateway device comprising a data allowance and limitation unit that is configured to limit communication between the medical machine and the network when the data allowance and limitation unit is in an open state, wherein the data allowance and limitation unit is placed in the open state when a plannable system event occurs, and wherein, while in the open state, the data allowance and limitation unit is placed in a closed state when an unplanned event occurs, thereby providing less limited communication between the medical machine and the network compared to the open state.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
H04M 1/14 - Supports for sets, e.g. incorporating armrests with resilient means to eliminate extraneous vibrations
The present invention relates to a disposable (4000), which has a fluid line (4002) and a connector (4001) with a connector lumen (4004), for fluidically connecting the fluid line (4002) to a first lumen (31) of a first fluid conduit (3) of a port (100), which further has a second lumen (51). The invention also relates to a system having a disposable (4000) according to the invention and having a port (100) for producing a fluid connection between at least one fluid line (2002) of a treatment device (2000), said fluid line being assigned to the interior (I) of the treatment device (2000), and the connector (4001) of the fluid line (4002) of the disposable (4000), said fluid line being assigned to the exterior (Ä) of the treatment device (2000).
The present invention relates to a port (100) for establishing a fluidic connection between at least one fluid line (2002) of a treatment apparatus (2000) associated with the interior (I) of the treatment apparatus (2000) and a connector (4001) of a fluid line (4002) of a fluid-conducting disposable (4000) associated with the exterior (Ä) of the treatment apparatus (2000), the port (100) having at least a first fluid guide (3) and a second fluid guide (5). The first fluid guide (3) has at least a first lumen (31) and a first end opening (32), which are provided to receive and/or guide a first medical fluid and to establish the fluidic connection to the connector (4001). The second fluid guide (5) has at least a second lumen (51) and a second end opening (52). The first end opening (32) of the first fluid guide (3) is, at least in regions, arranged in the second lumen (51) of the second fluid guide (5). The invention further relates to medical treatment apparatus and to a system.
A61M 39/16 - Tube connectors or tube couplings having provision for disinfection or sterilisation
A61M 39/18 - Methods or apparatus for making the connection under sterile conditions, i.e. sterile docking
A61M 39/20 - Closure caps or plugs for connectors or open ends of tubes
18.
ACCESS SYSTEM FOR A MEDICAL DEVICE FOR WITHDRAWING A MEDICAL FLUID, MONITORING SYSTEM COMPRISING SUCH AN ACCESS SYSTEM AND MEDICAL TREATMENT COMPRISING SUCH A MONITORING SYSTEM
The invention relates to an access system (1) for a medical device which has a housing body (21) equipped with an inner tube line section (22) for transporting a medical liquid, said tube line section being enclosed by an outer tube line section (24), thereby forming an empty area (23) for receiving a disinfection liquid, wherein the housing body (21) has an opening (25) which can be closed by a closure element. The access system (1) according to the invention is characterized in that a measuring electrode (30) and at least one counter electrode (31, 32) are arranged in the housing body (21) such that the measuring electrode (30) is operatively connected to the counter electrode via the empty area (23). The measuring electrode (30) allows an electric signal to be fed such that a current flowing between the measuring electrode and the counter electrode or a voltage applied between the measuring electrode and the counter electrode can be analyzed. On the basis of the analysis of the current or voltage, the presence or the absence of a liquid in the empty area (23) or humidity in the empty area and/or whether a specific liquid is present in the empty area (23) can be determined. The invention additionally relates to a monitoring system (2) comprising such an access system (1), to a medical treatment device (1) comprising such a monitoring system (2), and to a method for monitoring an access system for a medical device.
The present invention relates to a closing element for a fluid line, preferably a fluid line of a concentrate container, comprising a closing portion configured to be arranged on an end portion of the fluid line to fluidically close the fluid line, wherein the closing portion comprises an intended breaking point, and a pressure receiving portion configured to receive pressure applied by a connector element to be fluidically connected to the fluid line by breaking the intended breaking point, wherein the pressure receiving portion comprises at least one protrusion projecting outwards from at least a part of the closing element that is configured to come into contact with the connector element.
The present teachings generally include parabiotic dialysis systems and techniques. For example, the present disclosure includes parabiotic liver dialysis, e.g., for use in settings with limited resources. To this end, a parabiotic liver dialysis system may include a device having a semipermeable membrane with an average pore size that allows for the passage of albumin therethrough. In such a system, a first extracorporeal circuit may connect the device to the vascular system of a first animal (e.g., a liver patient), and a second extracorporeal circuit may connect the device to the vascular system of a second animal (e.g., a human with normal liver function), where the exchange of albumin therebetween is facilitated through the device. The present disclosure also includes various safety measures for parabiotic dialysis systems and techniques, such as biometric verification systems and techniques.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
21.
HOLLOW FIBER MEMBRANE FOR SEPARATING BLOOD PLASMA FROM BLOOD
The invention relates to a hollow fiber membrane for separating blood plasma from blood, comprising a blood contact layer and a support layer, each having a hydrophobic polymer, a hydrophilic polymer and vitamin E, and to a method for producing this hollow fiber membrane for providing a hollow fiber membrane. The hollow fiber membrane is characterized by a reduced hemolysis activity, so that the hollow fiber membrane can be advantageously used in plasmapheresis methods.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
The present invention relates to a method for disconnection of two fluid-conducting line portions of a medical device that are releasably connected to each other, wherein a first line portion of the two line portions at least partially has an elastic characteristic. The method comprises the steps of enclosing a fluid volume in the two line portions, of generating a negative pressure in the two line portions, as a result of which elastic deformation takes place in and/or on the first line portion from a starting position into a tensioning position, wherein a fluid volume encompassed by the first line portion is smaller in the tensioning position than a fluid volume encompassed in the starting position, and releasing the connection between the line portions, wherein the fluid volume encompassed by the first line portion in the tensioning position is increased. Furthermore, the invention relates to a medical device which is configured for carrying out such a method.
In one aspect, a method for optimizing a therapy for osteoporosis is disclosed, which comprises (a) generating in silico a plurality of virtual patients, wherein each of the virtual patients comprises a mathematical construct for modeling progression of osteoporosis via simulation of bone remodeling, said mathematical construct comprising a plurality of dynamic mathematical relations defining time-dependent evolution of at least one of a cell density variable or concentration variable associated with any of pre-osteoblasts, osteoblasts, preosteoclasts, osteoclasts, osteocytes, a bone resorption signal, sclerostin, estrogen, bone density and bone mineral content and employs a processor to determine time-variation of at least one of bone mineral density and bone mineral fraction based on at least a portion of said time- dependent variables, (b) applying a simulated therapy to said plurality of virtual patients, and (c) using said virtual patients to determine an effect of said simulated therapy on progression of osteoporosis.
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
24.
EXTRACORPOREAL BLOOD TREATMENT APPARATUS AND METHOD FOR OPERATING AN EXTRACORPOREAL BLOOD TREATMENT APPARATUS
The invention relates to an extracorporeal blood treatment device which has a blood treatment unit 1 which is divided by a semipermeable membrane 2 into a first compartment 3, which is part of a liquid system II, and a second compartment 4, which is part of an extracorporeal blood circuit I. Furthermore, the invention relates to a method for operating a blood treatment device of this kind. The blood treatment device according to the invention has a pressure-based control device 32 which cooperates with the control unit for a valve device 21 and is designed in such a way that a liquid connection between an upstream portion 20A and a downstream portion 20B of a flow path 20 can be established for a particular operating mode only if the pressure-based control device 32 detects an operating state in which it is ensured that, for a particular operating mode, liquid flows in the flow path 20 in the direction of a flow path 10 leading to an outlet 11. It is thus ensured that the liquid in question can flow only into the flow path 10 that leads to the outlet 11, but cannot pass into another flow path 8 in which fresh treatment liquid is located.
The present invention relates to a method for determining a time (t1, , t5) for measuring pressure values of a patient, or for recommending such a time, during a blood treatment session. The method comprises monitoring the ultrafiltration rate (UF_rate) at which the patient's blood is treated, the relative blood volume (RBV) and/or a sodium concentration ([Na+]) or a change thereto for the presence or fulfilment in each case of a predefined criterion for corresponding values or the change thereto. The method also comprises transmitting a signal to a provided blood-pressure measuring device (700) if or as soon as the predefined criterion is fulfilled for the ultrafiltration rate (UF_rate), for the relative blood volume (RBV) and/or for the sodium concentration ([Na+]) or the change thereto.
The invention relates to a device and method for filling and flushing the hydraulics of a dialysis machine, thereby ensuring removal of air bubbles from the hydraulics.
In one aspect, a system includes a blood treatment machine; a dialyzer configured to be coupled to the blood treatment machine, the dialyzer including a dialyzer housing defining a blood inlet and a blood outlet; a bundle of hollow fibers within an interior of the dialyzer housing; a pumping device drivable to force blood received from the blood inlet through lumens of the bundle of hollow fibers and out the blood outlet; a dialysate inlet port in fluid communication with a dialysate flow path that includes space in the interior of the dialyzer housing between the bundle of hollow fibers; and a dialysate outlet port in fluid communication with the dialysate flow path. The system further includes a fluid conditioning system configured to (i) prepare and supply fresh dialysate to the dialyzer via the dialysate inlet port, and (ii) receive spent dialysate from the dialyzer via the dialysate outlet port, recycle the spent dialysate, and supply the recycled dialysate to the dialyzer via the dialysate inlet port.
Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.
Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
A61M 1/26 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes which are moving
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A61M 60/419 - Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being permanent magnetic, e.g. from a rotating magnetic coupling between driving and driven magnets
Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.
Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.
Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
A61M 1/26 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes which are moving
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.
Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
35.
PRINTABLE ELECTRICAL COMPONENT COMPRISING A PLASTIC SUBSTRATE
The invention relates to a medical product, comprising a printable electrical cornponent (1), the printable electrical component (1) cornprising a plastic substrate (L1), at least one electrical part (E) being applied to the plastic substrate, the electrical part (E) comprising a dried conductive ink, the plastic substrate being selected from a group comprising polycarbonate, cyclic olefin copolymers, polyrnethyl methacrylate and polypropylene, the dried conductive ink comprising silver and/or gold, the electrical part (E) comprising spring-like and/or serpentine and/or spiral portions, the medical product also comprising a fluid conductor, the printable electrical cornponent being located on the exterior of the fluid conductor. The invention further relates to a rnedical product, cornprising a printable electrical component (1), the printable electrical component (1) comprising a plastic substrate (L1), at least one electrical part (E) being applied to the plastic substrate, the electrical part (E) comprising a dried conductive ink, the plastic substrate being selected frorn a group comprising polycarbonate, cyclic olefin copolyrners, polymethyl methacrylate and polypropylene, the dried conductive ink cornprising silver and/or gold, the electrical part (E) comprising at least one conductor portion or at least two electrodes, characterized in that the electrical part (E) is part of a strain sensor and/or part of a thermal flow sensor.
The present invention refers to a system and method for opening a concentrate container without the need for a human to directly handle the concentrate container and connecting the concentrate container to a blood treatment device. Aspects of the invention are directed to a container for concentrate and a blood treatment device.
The present invention relates to a medical connector with automatic sealing upon disconnection and to a method for connecting/disconnecting a medical connector.
In some embodiments, a medical system includes a dialysis machine having at least one outer surface to be disinfected at a given location, at least one disinfection sensor connected to the dialysis machine at the given location, the disinfection sensor including two or more electrode in fluid contact with the outside surface of the dialysis machine, and a conductivity sensor component in electrical contact with the two or more electrodes, the conductivity sensor component configured to send an electrical signal indicating a conductivity of a liquid on an outside surface of the dialysis machine and in contact with the two or more electrodes, a processor configured to receive the electrical signal and thereby determine a disinfection status of the given location, and a user interface configured to indicate the disinfection status of the given location.
The invention relates to a calculation apparatus (100) for determining an interdialytic sodium administration (minter) of a patient and/or for determining a non-osmotically based interdialytic fluid administration (Vexcess drink), having a storage apparatus (101) and/or an input apparatus (103) configured for storing and inputting parameter values of the patient; a computing device (105) configured for calculating the interdialytic sodium administration (minter) of the patient and/or for calculating their non-osmotically based interdialytic fluid administration (Vexcess drink); and an output apparatus (107) for outputting a signal for open-loop or closed-loop control of a communication apparatus (109) and/or a medical blood treatment apparatus (4).
The present invention relates to a reinfusion tube system (10) comprising a reinfusion fluid tubing comprising a pre-pump loop section (20), a post-pump loop section (30), and a pump loop section (40); and one of - a check valve (70) positioned at an end or between the ends of the reinfusion fluid tubing such that it is provided to block fluid flow through the check valve (70) in a direction from the post-pump loop section (30) to the pre-pump loop section (20), and - a check valve adapter (I, II, III) comprising a check valve (70), the check valve adapter (I, II, III) being configured to be connected to an end or to be positioned between the ends of the reinfusion fluid tubing such that the check valve (70) is provided to block fluid flow through the check valve (70) in a direction from the post-pump loop section (30) to the pre-pump loop section (20).
The present invention relates to a gear pump with a housing which has an inlet for the liquid to be conveyed and an outlet for the conveyed liquid, and a pump chamber, in which the gearwheel or gearwheels for conveying the liquid is/are situated, wherein at least on bearing location is situated in the housing, in which bearing location at least one gearwheel is received rotatably, wherein the inlet is situated in a different plane to the outlet, and wherein at least one first flushing channel which extends as far as the bearing location or locations is fluidically connected directly or indirectly to the inlet and/or to the outlet.
F04C 2/10 - Rotary-piston machines or pumps of intermeshing-engagement type, i.e. with engagement of co-operating members similar to that of toothed gearing of internal-axis type with the outer member having more teeth or tooth-equivalents, e.g. rollers, than the inner member
F04C 15/00 - Component parts, details or accessories of machines, pumps or pumping installations, not provided for in groups
The invention relates to a device for an extracorporeal blood treatment, comprising an extracorporeal blood circuit in which a dialyzer is arranged and comprising a dialysate circuit. The blood circuit is fluidically connected to a first chamber, and the dialysate circuit is fluidically connected to a second chamber of the dialyzer. The two chambers are separated by a semipermeable membrane, and a dialysate pump is provided in the dialysate circuit in order to pump the dialysis solution. The device has a control unit which is designed to operate the device in a first phase and a second phase which follows the first phase, and the dialysate pump is operated with a lower flow rate in the first phase than in the second phase and/or the dialysate pump pumps a dialysis solution with a higher concentration, with respect to at least one component, in the first phase than in the second phase.
The invention relates to a bag (1) made of a flexible wall, which bag is fitted with an inlet fluid line for introducing dissolution water, and with an outlet fluid line (121, 122) for extracting a solution obtained. According to the invention, the inside of the bag has a lower edge (13) in the overall shape of a V, the point of the V being further away from the centre of the bag than the arms of the V, the outlet fluid line opening into the bag as close as possible to the point of the V.
The invention relates to a connector (1) constituted by: - base provided with a tubular wall (13) closed by a bottom wall (11) provided with at least one through-opening (111); - a membrane provided with a flexible wall (23) having a central opening, a tubing (22) placed in the opening of the flexible wall; - sealing means for preventing a liquid from leaving the connector through the tubing; The base and the membrane are fixed to each other in a liquid-tight manner. The flexible wall allows axial displacement of the tubing so that it can be moved between a closed position, in which a liquid cannot leave the connector through the conduit of the tubing, and an open position, in which a liquid from can leave the connector through the tubing. Retaining means (121, 222a) maintain the tubing (22) closed with a force that can be overcome manually to open it.
FRESENIUS MEDICAL CARE DEUTSCHLAND, GMBH (Germany)
Inventor
Fuertinger, Doris H.
Kotanko, Peter
Rogg, Sabrina
Abstract
Systems, methods, and/or apparatuses may be operative to perform a dialysis process using RBV-based UF control. Embodiments may include methods operative to receive RBV target information comprising population-based dialysis data of real patient outcomes of a patient population associated with the patient, determine an RBV value of a patient during the dialysis process, and determine UF information to control a UF pump of the dialysis device to maintain the RBV value within a target RBV range defined by the RBV target information. Other embodiments are described.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
46.
DOSING DEVICE FOR SOLID MOLDED BODIES FOR PREPARING A SOLUTION
The invention relates to a device for producing a medical solution by adding substances present in solid moulded bodies into a solvent, comprising a mixing container, which can be filled with a solvent via an inlet, and from which the solution produced by the device can be supplied via an outlet, and which also has a feed opening via which the solid moulded bodies can be introduced into the mixing container. The device also comprises a metering device for controllable selective feeding of solid moulded bodies, or parts thereof, having different constituents and/or different concentrations of constituents from one or more storage containers which are held in one or more corresponding receptacles of the device and in which the solid moulded bodies can be removably held. The device may also have a coding and identification device for identifying and evaluating a mechanically evaluatable coding which is associated with a storage container and contains information concerning which constituents are contained in the solid moulded bodies stored in the respective storage container.
The invention relates to a peritoneal dialysis system comprising at least one peritoneal dialysis device and at least one organiser system, which is designed to support the peritoneal dialysis device and/or one or more functional elements, which are/can be connected to the peritoneal dialysis device, wherein the organiser system can be combined for transport or storage purposes, and same can be set up from the combined state to the functional state thereof for the purpose of carrying out the peritoneal dialysis treatment, wherein, at least in the set-up functional state, the organiser system has one or more support elements for supporting the peritoneal dialysis device itself and/or the functional element/s.
The invention relates to a composite material consisting of at least three components, a substrate material, a first fibrous reinforcement material and a second reinforcement material, the first fibrous reinforcement material having a coefficient of thermal expansion which is lower is than that of the second reinforcement material, and the second reinforcement material having an electrical conductivity which is lower than that of the first reinforcement material. The composite material is provided for uses in components for force and motion transmission, in particular provided for such components for force and motion transmission which come into contact with ultrapure water.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
C08J 5/04 - Reinforcing macromolecular compounds with loose or coherent fibrous material
The invention relates to a device for determining the static pressure of a patient, wherein the device comprises a pump connected to a patient line for conveying a dialysis solution into the abdomen of the patient, as well as blocking means, in particular a valve, via which the patient line can be blocked, wherein the device has a pressure chamber that is fluidically connected to the patient line when the blocking element is open, wherein a pressure measuring unit is further provided, which is arranged in such a way that it measures the pressure in the pressure chamber or a pressure correlating with same, wherein the device has a control unit which is designed in such a way that, in a first step, it brings about a pressure increase in the pressure chamber up to a measuring pressure, and in a second step, it opens the blocking element, such that the measuring pressure in the pressure chamber is applied to the patient line or a sub-section of same, and wherein the device has an evaluation unit which evaluates the measured pressure after the opening of the blocking element.
CIRCUIT ARRANGEMENT FOR PROTECTIVE-CONDUCTOR CONNECTION TO AT LEAST TWO FLUID-CONDUCTING LINES AND METHOD FOR TESTING A PROTECTIVE-CONDUCTOR CONNECTION
The invention relates to a circuit arrangement for connecting a protective conductor to at least two liquid-conveying lines (11, 12), particularly to at least two liquid-conveying lines leading from inside a housing (1) of a medical appliance, particularly the housing of a blood treatment appliance, to the outside. The circuit arrangement comprises a plurality of protective devices (16A, 16B; 17A, 17B) for electrical contacting, which are designed such that each one can be used to create an electrical connection to a liquid circulating in the line. At least two protective devices (16A, 16B; 17A, 17B) for electrical contacting are associated with each liquid-conveying line (11, 12) in the circuit arrangement. Two protective measures are therefore taken for each liquid-conveying line. Furthermore, the protective devices (16A, 16B; 17A, 17B) of a liquid-conveying line (11; 12) are respectively electrically connected to another protective device (16A,16B;17A, 17B) of another liquid-conveying line (11; 12). The protective conductor concept according to the invention improves the safety of the patients and allows easy checking of the protective conductor connections.
A method of operating an extracorporeal blood treatment system to infuse blood into a patient at an end of an extracorporeal blood treatment includes clamping an access line of an arterial line set. The method further includes, after clamping the access line, initiating an operation to generate negative pressure in the arterial line set. The method further includes, after generating the negative pressure in the arterial line set, unclamping the access line to draw fluid in the access line further into the arterial line set in a direction away from an end of the access line that is connectable to an arterial access of the patient. The method further includes initiating an operation of a fluid pump engaged with the arterial line set such that the fluid in the arterial line set is infused into the patient through a venous line set.
The present invention relates to an effluent bag (400) for collecting accumulated blood treatment effluent, comprising a or specifically one closeable effluent opening (400a) or connection to an exterior of the effluent bag (400). It further relates to methods, a blood treatment apparatus and a discharge hose system.
The invention relates to a pumping system for producing a volume flow of dialysis solution in a dialysis machine, the pumping system comprising at least one piston pump, the piston of which co-operates with a working fluid which in turn exerts a force on a conveyor means, in particular a membrane. Adjustment means are provided, by which the conveying volume of the piston pump per piston stroke can be reduced. The adjustment means comprise a mechanical piston stop, which can be varied in position, for reducing the piston stroke and/or means for reducing the amount of the working medium and/or means for reducing the volume of the conveying chamber which co-operates with the conveying means and contains the dialysis solution to be conveyed.
F04B 43/067 - Pumps having fluid drive the fluid being actuated directly by a piston
F04B 49/12 - Control of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for in, or of interest apart from, groups by varying the length of stroke of the working members
F04B 49/14 - Adjusting abutments located in the path of reciprocation
F04B 49/16 - Control of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for in, or of interest apart from, groups by adjusting the capacity of dead spaces of working chambers
The application refers to a medical treatment device (100) a medical treatment system and a method for operating the same for treatment of a patient, comprising a sensor interface (101) for receiving sensor data from a plurality of different external and internal peripheral sensors (102, 200), a controller (103) for processing the received sensor data in order to calculate control data and for providing the calculated control data for controlling medical treatment-related devices or for controlling configuration of medical treatment-related means and an output interface (105) for providing the control data.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A concentrate container for containing a concentrate, which is configured to form a dialysis solution after being diluted with a diluting agent, is connected in fluid communication with a first connector having a first code. The first code contains a first piece of information about the concentrate. The concentrate container is furthermore connected in fluid communication with a second connector having a second code differing from the first code. The second code contains a second piece of information about the dialysis solution. The second connector is located on a concentrate container side of the first connector, or alternatively the second connector is detachably located on a side of the first connector that is opposite the container side.
The present invention relates to an apparatus for performing peritoneal dialysis, the apparatus comprising means for delivering dialysis fluid to the peritoneal cavity of a patient, a measurement device for measuring the fluid pressure of the delivered dialysis fluid and/or the fluid pressure in the peritoneal cavity, i. e. the intraperitoneal pressure and/or any pressure related thereto, and a control unit operably connected to said means and the measurement device, wherein the control unit is configured to effect an inflow or outflow phase encompassing a series of fill-and-measurement or drain-and-measurement steps, each step comprising delivering a predetermined quantity of dialysis fluid to the peritoneal cavity or draining a predetermined quantity of dialysis fluid from the peritoneal cavity and subsequently measuring and recording a pressure value.
A peritoneal dialysis concentrate comprises an all-in-one concentrate or at least two concentrate parts to be stored separately before use, wherein by a diluting solution, the all-in-one concentrate can be diluted or dissolved, or the at least two concentrate parts can be diluted or dissolved, and mixed with each other to obtain the peritoneal dialysis solution suitable for peritoneal dialysis treatment. Also a single-chamber peritoneal dialysis bag, a dual-chamber peritoneal dialysis bag and a multi-chamber peritoneal dialysis bag contain the peritoneal dialysis concentrate. In addition, a set for a continuous ambulatory peritoneal dialysis and a set for an automated peritoneal dialysis comprise the single-chamber peritoneal dialysis bag or the dual-chamber peritoneal dialysis bag or the multi-chamber peritoneal dialysis bag, which contains the peritoneal dialysis concentrate. The peritoneal dialysis concentrate and the corresponding set for CAPD/APD can allow for saving logistic cost, easily transporting and only requiring minimum storage space.
The invention relates to a monitoring system (1) for at least one peritoneal dialysis appliance (PD1), the monitoring system (1) receiving data from a peritoneal dialysis appliance (PD1) to be monitored by means of a first data transmission network (NET1), the data being selected from a group comprising appliance data, error codes, operating data, environmental data, consumable data, network data, and processing data, the received data relating to a respective peritoneal dialysis appliance (PD1) being stored, at least individual elements of the stored data being evaluated in relation to the appliance. On the basis of the evaluation, an action selected from informing a patient (P), informing qualified medical staff (FP), informing service staff (SP), and informing a quality assurance representative (QB), is carried out by means of a second data transmission network (NET2).
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
59.
A DEVICE INCLUDING A DEVICE FOR DETERMINING A, PARTICULARLY GEOMETRIC, CHARACTERISTIC OF THE DEVICE
The present invention relates to an especially medical apparatus (200) comprising at least one hard unit (201) having fluid lines (202) conducting an especially medical fluid, especially blood, through the hard unit (201); a converter (205, 207, 209, 211), said converter (205, 207, 209, 211) being arranged for measuring a property (Q) of the fluid while the latter is present in one of the fluid lines (202); and a device for determining an especially geometrical property (dx, dy) of the apparatus (200), especially of a fluid line (202).
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
G01B 21/00 - Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant
G01D 21/00 - Measuring or testing not otherwise provided for
60.
HOLLOW FIBER MEMBRANE HAVING IMPROVED DIFFUSION PROPERTIES
The invention relates to a wavy, thermally stable hollow fiber membrane which has a reduced wall thickness of at least 20 µm and at most 30 µm and the wavy shape of which has a wavelength ranging from more than 1mm to less than 5 mm. The invention particularly relates to a method for manufacturing wavy, thermally stable hollow fiber membranes having a small wall thickness.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
An extracorporeal blood treatment device comprising a hydraulic system comprising a plurality of flow paths, and a control unit providing an operating mode for disinfecting the hydraulic system with a liquid supplied via one of the flow paths is disclosed. The hydraulic system has a valve device providing several switching positions. The valve device has an inlet for the disinfecting liquid and a plurality of outlets. In a switching position the inlet is connected to one of the outlets and in another switching position the inlet is connected to a plurality of outlets. The inlet of the valve device is in fluid communication with the flow path via which the disinfecting liquid can be supplied, and the outlets of the valve device are in fluid communication with another flow path of the hydraulic system, so that liquid can simultaneously be supplied to the individual flow paths.
The invention relates to the production of hollow fibre membranes based on a hydrophobic and a hydrophilic polymer which contain a water-insoluble antioxidant. The invention particularly relates to the production of hollow-fibre membranes for the extracorporeal treatment of blood, the hollow-fibre membranes having improved biocompatibility with blood to be treated, in particular resulting in less complement activation and lower platelet loss in blood to be treated. The elution of hydrophilic polymers from the lumen of the hollow fibre membrane is also reduced at the same time.
The invention relates to a method for producing a hollow fibre membrane bundle from a plurality of polysulphone-based and PVP-based hollow fibre membranes, involving: providing a spinning solution comprising a material based on polysulphone, particularly polysulphone, a polymer based on vinylpyrrolidone and particularly polyvinylpyrrolidone, an aprotic solvent, particularly dimethylacetamide; providing a coagulation liquid comprising water and an aprotic solvent, particularly dimethylacetamide; coextruding the spinning solution and the coagulation liquid through a concentric annular gap nozzle to form a hollow spun filament, the cavity of said spun filament being filled with coextruded coagulation liquid; passing the spun filament through a precipitation gap; introducing the spun filament into a precipitation bath substantially comprising water, in order to obtain a hollow fibre membrane; passing the hollow fibre membranes through at least one rinsing bath and drying the resulting hollow fibre membrane; arranging the resulting hollow fibre membrane to form a hollow fibre membrane bundle; and treating the hollow fibre membrane bundle with steam.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
The invention relates to a connection piece for producing a liquid connection between liquid-conveying lines for mounting in a recess of a housing part of a medical appliance, in particular of a dialysis appliance. In addition, the invention relates to a medical appliance, in particular a dialysis appliance, with a housing having a housing part with a recess into which such a connection piece is inserted. The connection piece 13 according to the invention has a tubular body 18 which is made of an electrically conductive material and which can be inserted into the recess 23 of the housing part 1A and whose end pieces 19, 20 are configured for the attachment of the liquid-conveying lines. The connection piece 13 is characterized by an attachment part 16 for the attachment of an electrical protective conductor or potential equalization element, wherein the attachment part 16 is connectable or connected to the tubular body 18 in an electrically conductive manner. The attachment part 16 permits direct attachment of an electrical connector cable 17 to a protective conductor 15 (PE conductor).
A precursor composition for the preparation of a dialysis fluid, the precursor composition comprising at least a glucose component, an acid component, and an amino acid component, wherein the amino acid component comprises Valine, Isoleucine and Leucine.
A tube connection part adapted to accommodate a flexible tube made from a material comprising polyvinyl chloride, wherein said tube connection part comprises a sleeve adapted to form an overlapping region between said tube connection part and said tube, wherein an adhesion promoting agent is deposited on at least a subsection of a surface of said sleeve, characterized in that the adhesion promoting agent comprises a styrene- butadiene block copolymer.
The invention relates to a medical device, in particular a blood cassette (200), comprising a device body (201), at least one fluid-holding chamber (1) for holding at least one first medical fluid (5), in particular blood, and at least one hydrophobic filter device (100) having a filter surface, through which at least one second, gaseous fluid (19), in particular air, can be fed to the fluid-holding chamber (1), wherein the filter device (100) has at least one filter membrane (9); wherein the filter membrane (9) has a back side (9a) and a front side (9b); wherein the filter membrane (9) is welded by means of the back side (9a) thereof to the fluid-holding chamber (1), to of a wall thereof, or to another section of the cassette body (201) along a weld section (203); wherein the filter device (100) has a front supporting structure (27) on the front side (9b), which front supporting structure is arranged to support the filter membrane (9); wherein the front supporting structure (27) is arranged to be in contact with the weld seam section (203) by means of a first contact section (27a) of the front supporting structure (27).
The invention relates to a medical treatment device having a hose set (20) and a peristaltic hose pump (6) for conveying fluid, and having a monitoring device (15) for monitoring the occlusion of the displacer (13A, 13B) of the hose pump. The invention further relates to a hose set (20) for a medical treatment device and to a method for monitoring the occlusion of the occlusion element of a peristaltic hose pump for conveying a fluid for a medical treatment device. The invention is based on the occlusion of the displacer (13A, 13B) of the peristaltic hose pump (6) being monitored in order to monitor the fluid flow in the hose line (5). In order to do so, the electrical resistance or a parameter correlating with the electrical resistance is measured between a first and a second electrode (16A, 16B), wherein the first electrode (16A) is arranged on the hose line (5), upstream of the occlusion element (12) of the peristaltic pump (6), and the second electrode (16b) is arranged on the hose line (5), downstream of the occlusion element, such that an electrical contact between the first and second electrode (16A, 16B) and the fluid flowing in the hose line (5) is produced. The electrodes (16A, 16B) are preferably an integral component of a connector (10), by means of which the hose segment (5A) to be inserted into the hose pump (6) is fixed in the form of a loop.
The invention relates to a hollow fibre membrane having at least one first texturing in the form of a first wave characterised by a first plane of oscillation and a first wave length, and at least one second texturing in the form of a second wave characterised by a second plane of oscillation and a second wave length, characterised in that the first plane of oscillation and the second plane of oscillation together enclose an angle which does not equal zero.
D01F 6/06 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polyolefins from polypropylene
D02G 1/00 - Producing crimped or curled fibres, filaments, yarns or threads, giving them latent characteristics
D02G 1/14 - Producing crimped or curled fibres, filaments, yarns or threads, giving them latent characteristics using grooved rollers or gear-wheel-type members
70.
DEVICE FOR EXTRACORPOREAL BLOOD TREATMENT HAVING AN EVALUATION AND CONTROL UNIT
The invention relates to a blood treatment device having an extracorporeal blood circuit which comprises an arterial line, a blood pump, a blood treatment unit and a venous line, wherein the arterial and venous lines can be connected to a blood vessel of a patient, and wherein the blood treatment device has an evaluation and control unit, wherein the evaluation and control unit is configured to carry out the following steps: (a1) determining the blood recirculation in a blood vessel of the patient connected to the extracorporeal blood circuit; and (b) calculating the blood flow in the blood vessel using the blood recirculation determined in accordance with (a1) and using a provided value or a value likewise previously determined for the cardiac output of the patient.
The invention relates to a method for checking a dialyzer for the presence of a leak in the semipermeable membrane of the dialyzer. The membrane divides the dialyzer interior into at least one blood chamber and at least one dialysate chamber. Blood flows through the blood chamber during the operation of the dialyzer, and the blood chamber is fluidically connected to a blood-side line system and the vascular system of the patient. Dialysis fluid flows through the dialysate chamber during the operation of the dialyzer, and the dialysate chamber is fluidically connected to a dialysate-side line system. The method has the following steps: a) emptying the blood chamber or the dialysate chamber, b) building up a test pressure, and c) measuring the pressure decrease and/or measuring the pressure increase, wherein steps a) to c) are carried out following the blood treatment of the patient and following the disconnection of the patient from the blood-side line system.
The invention relates to a device for the pressure-based detection of a clot in an extracorporeal blood circuit. The device comprises at least one cyclically operating pump for pumping the liquid located in the extracorporeal circuit and at least one pressure sensor, which is arranged so as to ascertain the current pressure curve over time in the liquid pumped by the pump in a current pump cycle, wherein the device has at least one storage device in which at least one reference pressure curve is stored based on at least one pressure curve over time that has been ascertained in a pump cycle of the pump preceding the current pump cycle of the pump, and the device comprises at least one analysis unit which is designed to compare the current pressure curve with the reference pressure curve in a time-corresponding manner.
The invention relates to a blood treatment device with an extracorporeal blood circulation, which uses a gas sensor to measure the concentration of a gas in the gas supernatant of the drip chamber of the extracorporeal blood circulation. The blood treatment device has an evaluation unit, which calculates the corresponding partial pressure of the gas in the blood from the values measured in the gas supernatant in the drip chamber.
The invention relates to a method for deaerating a dialyser comprising a dialysate chamber, a blood chamber, and a semi-permeable dialyser membrane which separates these two chambers, wherein, in order to remove entrapped air present on the dialysate chamber-side surface of the membrane, an excess pressure in relation to the blood chamber is produced in the dialysate chamber once said dialysate chamber has been filled and before the blood chamber is filled.
The invention relates to a dialysis solution or substitution solution containing bicarbonate ions as well as calcium ions and/or magnesium ions, wherein the dialysis solution or the substitution solution furthermore contains an organic ester of phosphoric acid.
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61P 7/08 - Plasma substitutesPerfusion solutionsDialytics or haemodialyticsDrugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
76.
METHOD FOR CHECKING A CONNECTION STATE BETWEEN A BLOOD TREATMENT APPARATUS AND A BLOOD TUBING SET, AND APPARATUSES
The invention relates to a method for checking a connection between a compressed air outlet (1001) of a blood treatment apparatus (1000) and a pressure measuring line (105) of an extracorporeal blood tube set (100), wherein the method comprises the steps: providing a blood treatment apparatus (1000) which has a compressed air line (1005); a compressed air device (1003) in fluid communication with the compressed air line (1005) for generating pressure within the compressed air line (1005); a compressed air outlet (1001) in fluid communication with both a compressed air line (1005) and an exterior of the blood treatment apparatus (1000), wherein the compressed air outlet (1001) is designed in order to be connectable to a pressure measuring line (105); and a pressure sensor (1007) which is arranged for measuring the prevailing pressure (P) at the compressed air outlet (1001) or in the compressed air line (1005); building up of a pressure and an air flow in the compressed air line (1005) and/or at the compressed air outlet (1001) by means of the compressed air device (1003); measuring of a prevailing pressure (P) at the compressed air outlet (1001) or in the pressure line (1005), or of a pressure change over time by means of the pressure sensor (1007); and evaluating of a rise in the measured pressure (P) or of a rise in the measured pressure over time, respectively by means of a comparison of the measured pressure (P) or a measured pressure rise with the previously measured or stored values, threshold values (P-V), regions or profiles.
The present invention relates to a dialysis solution containing bicarbonate, calcium and phosphate, said dialysis solution containing phosphate at a concentration in the range of up to 0.4 mmol/l, preferably in the range of up to 0.375 mmol/l or in the range of up to 0.25 mmol/l, and particularly preferably in the range of up to 0.2 mmol/l.
The present invention relates to an apparatus for treating a patient by tidal peritoneal dialysis, the dialysis treatment comprising a succession of cycles each having a fill period, a dwell period and a drain period, the apparatus having at least one cycler suitable for filling the patient's abdominal cavity with a defined admission volume of fresh dialysis solution until attainment of a defined patient volume in the fill period and for draining spent dialysis solution from the patient's abdominal cavity until attainment of a defined tidal discharge target in the drain period, the apparatus further having at least one processor which drives the cycler in at least one operating mode such that the drain period is ended before the tidal discharge target is attained, so that an allowable residual volume remains in the abdominal cavity and then a fill period is commenced, and the fill period is implemented in such a way that when the fill period has finished the fill volume of the patient is at an allowable patient volume which is above the defined patient volume.
The invention relates to a dialysis machine with the capability of determining a pre-dialysis property in the blood of a dialysis patient, which dialysis machine comprises an extracorporeal blood circuit, a dialysate circuit, a dialyzer and a computing unit, wherein at least one sensor for determining a property of the dialysate is arranged in the dialysate circuit. The computing unit is configured in such a way that, during an initial phase of the dialysis treatment, temporal evaluation ranges are established in which all stability criteria from a predetermined group are satisfied, and in such a way that measurement values determined by the at least one sensor are used to determine a pre-dialysis property of the patient's blood only within these temporal evaluation ranges.
The present invention relates to a device for determining the peritoneal pressure in the abdominal cavity of a patient and/or for determining the state of emptying of the abdominal cavity of a patient, wherein the device comprises at least one pump for delivering a dialysis solution into the abdominal cavity and at least one measuring device for measuring the pressure in the dialysis solution, wherein the device comprises at least one control unit which is configured in such a way that it controls the pump and the measuring device in such a way that, in order to obtain a first pressure measurement value, a first measurement of the pressure is carried out by the measuring device when the pump is stationary, after which the pump for delivering a partial volume of the overall volume of the dialysis solution flowing into the abdominal cavity is started up and the pump then stops and, thereafter, in order to obtain a second pressure measurement value, a second measurement of the pressure is carried out by the measuring device.
A device is provided for detecting the direction of fluid flow through a dialyser that comprises a blood chamber, through which blood flows, and a dialysate chamber, through which dialysate flows, which are separated from one another by a semi-permeable membrane. The device for detecting the direction of fluid flow comprises a measuring unit for measuring clearance or a value characteristic of the clearance, and an arithmetic and evaluation unit, which is configured such that the measured clearance or the value characteristic of the clearance is compared to a specified limit value. The direction of blood flow through the blood chamber and dialysate flow through the dialysate chamber are determined as being in countercurrent flow if the clearance or the value characteristic of the clearance is greater than the specified limit value.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
82.
METHOD FOR REMOVING FLUID FROM A BLOOD FILTER AFTER COMPLETING A BLOOD TREATMENT SESSION BY MEANS OF FLOW INCREASE AND TREATMENT APPARATUS FOR CARRYING OUT SAID METHOD
The present invention relates to a method for removing fluid from a blood filter for the blood treatment of a patient and/or for removing blood from the flood filter after completing the blood treatment session. It further relates to a control and/or regulating device, a medical treatment apparatus having a control and/or regulating device with which the method according to the present invention is executable, a digital storage medium, a computer program product as well as a computer program.
The present invention relates to a method for removing blood from an extracorporeal blood circuit and/or a functional device, each of which is connectable with a blood treatment apparatus for performing a blood treatment of a patient, after concluding a blood treatment session. The blood treatment apparatus comprises or is connected with at least one extracorporeal blood circuit with a line interior, the extracorporeal blood circuit comprising at least one blood pump for conveying blood within the line interior. The method encompasses the step of operating the blood pump in a second conveying direction which is opposite to the first conveying direction of this pump which is customary during the blood treatment. A first section of an arterial line section of the line interior is or will be connected with a second section of a venous line section of the line interior of the extracorporeal blood circuit.
The invention relates to a functional medical device (900) with a valve seat (803) for a non-return valve (1). In addition to a first position which is suitable for sterilizing gas, the non-return valve (1) is designed to assume a second functional position, in which the non-return valve (1) exerts a non-return function, by applying a force onto a portion of the non-return valve (1) and/or by moving the non-return valve. The non-return valve (1) is designed to remain in the second position after being successfully converted into the second position after the force and/or the moving element has been removed.
The present invention relates to a fluid cassette, e.g. a blood treatment cassette (1000) comprising a cassette body, which is designed as a hard part (1), and optionally a film (3), which is connected to the hard part (1) and covers the hard part (1) at least in sections thereof, the hard part (1) comprising at least a first centering device (504) and a second centering device (505) which are optionally arranged on or associated with opposite first and second sides of the fluid cassette (1000). The invention further relates to a blood treatment device.
The present invention relates to a blood treatment cassette having a cassette body, embodied as a hard part, and a film, wherein the film is connected with and covers the hard part at least partially, wherein the hard part (comprises at least one valve seat or valve section or one valve base of a valve, wherein the valve is embodied to take, in addition to a first, open position of the valve in which the valve base and the section of the film positioned above it do not touch each other, a second, closed position of the valve when applying force on the section of the film and wherein the valve base, in its longitudinal extension, comprises or is a non-straight section. It relates furthermore to a blood treatment apparatus connected with a blood treatment cassette.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
A61M 39/12 - Tube connectors or tube couplings for joining a flexible tube to a rigid attachment
F16K 7/12 - Diaphragm cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage with flat, dished, or bowl-shaped diaphragm
87.
PRESTRESSED VALVE FOR A MEDICAL FUNCTIONAL DEVICE AND A MEDICAL FUNCTIONAL DEVICE
The present invention relates to a valve arrangement (1) for a medical functional device (900), said valve arrangement (1) having a valve body (802) which is connected to a cap (801) produced separately, the valve body (802) comprising at least one element or spring element (823) that effects prestressing of the valve body (802) in the cap (801).
The present invention relates to a blood treatment cassette having a body designed as a hard part and a film, where the film connects with the hard part and covers the hard part at least partially. The hard part including at least one valve seat or section or valve base for a valve, wherein the valve is embodied to take a first, open position of the valve in which the valve base and the section of the film positioned above are not in contact, and a second, closed position when power is applied on the section of the film. The blood treatment cassette further including at least one springy or elastic spacer supported at the hard part or produced integrally therewith, wherein the spacer is arranged so that it applies stress, power or pressure in the first position on the section of the film positioned above the valve base.
F16K 7/12 - Diaphragm cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage with flat, dished, or bowl-shaped diaphragm
89.
BLOOD TREATMENT CASSETTE WITH FILM VALVE AND INELASTICAL SPACER AS WELL AS BLOOD TREATMENT APPARATUS
The invention relates to a blood treatment cartridge (1000) with a cartridge body, which is designed as a hard part (1), and a film (3). The film (3) is connected to the hard part (1), and the hard part (1) is at least partly covered. The hard part (1) has at least one valve base (226) of a valve (288), and the valve (288) is designed to assume a second closed valve (288) position, in which the valve base (226) and a valve (3) section arranged over the valve base contact each other, in addition to a first open valve (288) position, in which the valve base (226) and the film (3) section do not contact each other, by applying a force onto the film (3) section.
A screw connector for a medical hose system is disclosed. The connector includes a first connecting element and a second connecting element, which are configured to be screwed to one another. The first connecting element and the second connecting element are each configured to be gas-permeable between an outer environment of the screw connector and an interior of the screw connector in a predetermined second angle-of-rotation range. The first connecting element and second connecting element are each configured in order to seal in a gas-tight and/or fluid-tight manner between the outer environment of the screw connector and the interior of the screw connector when screwed together in a third angle-of-rotation range.
A screw connector for a medical tubing system is disclosed. The connector includes a first connecting element and a second connecting element, which are configured to be screwed together. The first connecting element and the second connecting element are each configured to be gas-permeable between the outside surroundings of the screw connector and an interior of the screw connector in a predetermined second angle-of-rotation range. The first connecting element and the second connecting element are each configured to form an air-tight and/or fluid-tight seal between the outer surroundings of the screw connector and the interior of the screw connector when screwed together in another angle-of-rotation range.
The invention relates to a cover device for covering a hose system that can be connected to a patient and has a flat structure with a liquid sensor. The liquid sensor is arranged within a convolution of the flat structure in such a way that leaks on the connectors of the hose system can be detected by said liquid sensor, even if the hose system is concealed by the cover device.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
G01M 3/04 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point
G01M 3/16 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means
G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
The present invention relates to a novel dry acid concentrate (DAC) for a dialysis liquid and to a dialysis liquid, which is made from said concentrate, and which may be used for purifying blood. The invention further relates to a method of making the dry acid concentrate as well as the dialysis liquid. It also relates to a container (10) comprising said acid concentrate, and which is - in certain embodiments - specially adapted to a dialysis unit.
The invention pertains to the regulation and specification of pump rates of blood pumps. The invention relates to a device and a method in which blood pressures are monitored upstream and/or downstream of the blood pump, and said values or another value formed from said values is compared with a threshold which depends on an operating parameter of the blood pump or a pump parameter of the blood pump. When the threshold is violated, the pump rate of the blood pump is changed or a new pump rate is determined such that the threshold is no longer violated or the degree of the violation is reduced.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
FRESENIUS MEDICAL CARE DEUTSCHLAND G.M.B.H. (Germany)
Inventor
Tetta, Ciro
Camussi, Giovanni
Giunti, Sara
Navarro Tableros, Victor Manuel
Abstract
The invention relates to a method of preparing pancreatic islet-like cell structures characterized by a unique combination of morphological and functional features which make them particularly suitable for use in both clinical and drug screening application, as well as to the pancreatic islet-like cell structures obtained therefrom.
The present invention relates to a combination of a container comprising a connecting portion and of a fluid preparation device, in particular a dialysis machine, which fluid preparation device is suitable for mounting and connecting the connecting portion of the container, wherein the fluid preparation device comprises at least one line which is in fluid communication with the interior of the container at least in the connected position of the container, the container being filled with a first medium, wherein the combination and preferably container comprises a reservoir containing a second medium, wherein the fluid preparation device comprises means for opening the reservoir so that the first and second medium are mixed with each other.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
The invention relates to a connector comprising at least one first connector part and at least one second connector part. The connector parts can be connected to one another in a fluid-tight manner and can be locked to one another via at least one closure element. One of the connector parts has at least one openable seal element which blocks a flow in the closed state, in particular a septum or a seal disk, and the other connector part has at least one opening element for opening the seal element. One of the connector parts has at least one protrusion, and the other connector part has at least one receiving area, the opening element and the seal element being arranged relative to each other such that the opening element opens the seal element only when the protrusion is inserted into the receiving area.
The invention relates to a method and a device for monitoring an extracorporeal blood circuit I during an extracorporeal blood treatment using an extracorporeal blood treatment device. The invention further relates to an extracorporeal blood treatment device with a device for monitoring an extracorporeal blood circuit. The method according to the invention and the device according to the invention are based on carrying out the monitoring process of the arterial and/or venous access to the patient using a first and a second method in order to increase the redundancy, wherein the presence of at least one criterion characterizing an incorrect state of the vessel access is checked in each method, the criteria of the first and second methods being different from one another. In the method according to the invention and the device according to the invention, the blood pump (9), which is preferably an occluding blood pump, is stopped after the presence of the at least one criterion of the first method is ascertained, whereas the venous closure element (17) remains open, however. The presence of the at least one criterion of the second method is checked after the blood pump (9) has been stopped. The venous closure element (17) is closed only if the at least one criterion of the second method is present. Otherwise, the blood pump (9) is restarted in order to continue the blood treatment.
The invention relates to a cassette module for processing blood and therapeutic fluids in an extracorporeal blood treatment, dialysis or infusion technology, comprising a base body (302), with a first side and a second side, fluid channels integrated into the base body, a receiving unit (304) to receive a centrifugal pump means for delivering fluids, characterized in that at least some of the fluid channels are arranged on a first side of the base body, and the receiving unit for the centrifugal pump means is arranged on the second side, and the receiving unit for the centrifugal pump means is in fluid connection with the fluid channels on the first side during operation.
A61M 60/37 - Haemodialysis, haemofiltration or diafiltration
A61M 60/422 - Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
A61M 60/847 - Constructional details other than related to driving of extracorporeal blood pumps arranged in a cassette
100.
CONTROL UNIT AND METHOD FOR DETERMINING THE PRESSURE IN A BLOOD VESSEL, IN PARTICULAR IN AN ARTERIOVENOUS FISTULA
The invention relates to a control unit for determining the pressure in a blood vessel, in particular in an arteriovenous fistula, which is in fluid connection with at least one section of a blood line system, in particular an extracorporeal blood circulation, at least one pressure-generating device being assigned to the blood line system, this pressure-generating device being suitable for acting on the section, and the control unit being configured to perform the following steps:a) being sure that none of the at least one pressure-generating device acts on the section,b) interrupting the fluid connection of the section with the blood vessel by triggering an interrupt means,c) setting the pressure in the section at a predetermined ideal value, in particular at the ambient pressure, with the help of a pressure sensor in the section,d) restoring the fluid connection of the section with the blood vessel by triggering the interrupt means, ande) measuring a resulting pressure in the section with the help of the pressure sensor.
patents
