The invention relates to a method for controlling pressure in a fluidic system, the method comprising:
providing:
a plurality of measurements from a pressure sensor, and)
a pressure setpoint,
computing a predictive model using at least a part of the measurements;
computing a deviation between a value of one of the plurality of measurements and a value of the setpoint; the deviation being further based on the predictive model;
computing a gain being based on the value of the setpoint and/or on the value of the one of the plurality of measurements;
computing a first correction factor based on the computed deviation and the computed gain;
computing a second correction factor based on the computed deviation, the computed gain and a previous value of the second correction factor;
computing an actuator command based on the first correction factor and the second correction factor; and
applying the computed actuator command to the fluidic system via one or more actuators configured to modify a value of the pressure.
G05D 16/20 - Control of fluid pressure characterised by the use of electric means
G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
2.
APPARATUS FOR FEEDING A LIQUID MEDIUM TO A FLUIDIC SYSTEM COMPRISING MAGNETIC AGITATION
The present invention relates to an apparatus (100) for feeding a fluidic system (110) with liquid medium, the apparatus (100) comprising a manifold and a cartridge removably mounted on the manifold:
wherein the cartridge comprises one or more reservoirs, each reservoir comprising:
at least one gas inlet, and
at least one liquid inlet or outlet;
wherein the manifold comprises:
a pressure control unit comprising one or more gas lines;
one or more magnetic field generators;
wherein the apparatus further comprises at least one connection configured to be connected to an inlet and/or an outlet of the fluidic system;
wherein, when the cartridge is mounted on the manifold:
the gas lines of the pressure control unit are connected to the gas inlets of the one or more reservoirs and are configured to control gas pressure in the one or more reservoirs; and
each magnetic field generator is configured to provide magnetic agitation in at least one of the reservoirs by generating a magnetic field in said reservoir.
The present invention relates to an apparatus (100) for feeding a fluidic system (110) with liquid medium, the apparatus (100) comprising a manifold and a cartridge removably mounted on the manifold;
wherein the cartridge comprises one or more reservoirs, each reservoir comprising:
wherein the cartridge comprises one or more reservoirs, each reservoir comprising:
at least one gas inlet, and
at least one liquid inlet or outlet;
wherein the manifold comprises:
a pressure control unit comprising one or more gas lines;
one or more liquid level sensors;
wherein the apparatus comprises at least one connection configured to be connected to an inlet and/or an outlet of the fluidic system;
wherein, when the cartridge is mounted on the manifold:
the gas lines of the pressure control unit are connected to the gas inlets of the one or more reservoirs and are configured to control gas pressure in the one or more reservoirs; and
each liquid level sensor is configured to detect a level of liquid in at least one of the reservoirs.
The present invention relates to an apparatus for feeding a fluidic system with liquid medium, the apparatus comprising a manifold and a cartridge:
wherein the cartridge comprises one or more reservoirs, each reservoir comprising:
at least one gas inlet, and
at least one liquid inlet or outlet;
wherein the manifold comprises:
a pressure control unit comprising one or more gas lines;
wherein the apparatus further comprises at least one connection configured to be connected to an inlet and/or an outlet of the fluidic system;
wherein:
in a locked position, the cartridge is pressed against the manifold and the gas lines of the pressure control unit are connected to the gas inlets of the one or more reservoirs and are configured to control gas pressure in the one or more reservoirs; and
in an unlocked position, the cartridge is removable from the manifold.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT CURIE (France)
FLUIGENT (France)
Inventor
Bouquerel, Charlotte
Descroix, Stéphanie
César, William
Dumas, Simon
Gropplero, Giacomo
Viovy, Jean-Louis
Abstract
The invention relates to a fluidic chip (101) comprising: - a first slide (100), the first slide (100) being made in a first material having an oxygen permeability of 10-9cm3(STP).cm.cm-2.s-1.cmHg-1or less at 25°C; - a second slide (104) comprising a channel (106), the second slide (104) being made in a second material having an oxygen permeability of 10-9cm3(STP).cm.cm-2.s-1.cmHg-1or less at 25°C; - a first adhesive layer (114) joining the first slide (100) to the second slide (104), the first adhesive layer (114) being made in a first adhesive composition having an oxygen permeability of 10-9cm3(STP).cm.cm-2.s-1.cmHg-1 or less at 25°C.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT CURIE (France)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERHE MEDICALE (INSERM) (France)
Inventor
Bouquerel, Charlotte
César, William
Viovy, Jean-Louis
Gentric, Géraldine
Descroix, Stéphanie
Parrini, Maria-Carla
Mechta-Grigoriou, Fatima
Abstract
The invention relates to a method for monitoring at least one substance which may be produced or consumed by at least one living entity, and to an assembly for implementing the method. The method comprises flowing liquid medium having a controlled concentration of a dissolved gas and a controlled flow rate to a culture system and taking at least one measurement within the culture system so as to determine the presence, concentration or amount of the at least one substance in the liquid medium in the culture system; and/or taking at least a first measurement upstream of the culture system and a second measurement downstream of the culture system, and determining a concentration or amount of the substance consumed or produced by the at least one living entity based on the difference between the second measurement and the first measurement.
The present invention relates to an apparatus for feeding a fluidic system with liquid medium, the apparatus comprising:
a recirculation input reservoir, an injection reservoir, a recirculation output reservoir and a sampling reservoir, each reservoir comprising a gas inlet, and a liquid inlet or liquid outlet equipped with a check valve;
a refill channel equipped with a check valve from the input reservoir to the recirculation output reservoir;
a pressure control unit comprising gas lines connected to the gas inlets of the reservoirs and configured to control gas pressure in the reservoirs;
the apparatus being configured to be connected to an inlet and an outlet of the fluidic system.
Examples are disclosed that relate to an apparatus for controlling pressure or flow in a fluidic system. The apparatus comprises a main inlet/outlet and a uni-directional pumping device configured to pump gas from an inlet of the pumping device to an outlet of the pumping device. The apparatus further comprises a valves array and a control unit. The control unit is configured to set the valves array into at least two states. In a first state, a first gas source is fluidically connected to the inlet of the pumping device, and the outlet of the pumping device is fluidically connected to the main inlet/outlet. In a second state, the main inlet/outlet is fluidically connected to the inlet of the pumping device, and the outlet of the pumping device is fluidically connected to a second gas source.
The present invention relates to an apparatus (2) for controlling pressure or flow in a fluidic system (3), the apparatus (2) comprising: a first connection device (301) comprising a pumping device (304) and a main outlet (310); a second connection device (302) comprising a flow restriction (305); a third connection device (303) comprising a valve with a modifiable aperture (306); wherein the second connection device (302) and the third connection device (303) are connected to the first connection device (301) at a position between the pumping device (304) and the main outlet (310).
The invention relates to a method for controlling pressure in a fluidic system, the method comprising: - providing: * a plurality of measurements from a pressure sensor, and) * a pressure setpoint, - computing a predictive model using at least a part of the measurements; - computing a deviation between a value of one of the plurality of measurements and a value of the setpoint; the deviation being further based on the predictive model; - computing a gain being based on the value of the setpoint and/or on the value of the one of the plurality of measurements; - computing a first correction factor based on the computed deviation and the computed gain; - computing a second correction factor based on the computed deviation, the computed gain and a previous value of the second correction factor; - computing an actuator command based on the first correction factor and the second correction factor; and - applying the computed actuator command to the fluidic system via one or more actuators configured to modify a value of the pressure.
G05D 16/20 - Control of fluid pressure characterised by the use of electric means
G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
11.
DEVICE FOR PROVIDING A LIQUID MEDIUM WITH A CONTROLLED FLOW RATE AND WITH A CONTROLLED DISSOLVED GAS CONCENTRATION
Centre National De La Recherche Scientifique (France)
Institut Curie (France)
Fluigent (France)
Inventor
Cesar, William
Bouquerel, Charlotte
Verhulsel, Marine
Viovy, Jean-Louis
Descroix, Stéphanie
Abstract
The present invention relates to a device (2) for providing a liquid medium with a controlled flow rate and with a controlled concentration of a dissolved gas, the device (2) comprising: —a liquid reservoir (4) provided with: —at least one gas inlet (7); —at least one gas outlet (8); and—at least one liquid outlet (9); —an admission line (5) configured to provide a gaseous medium into the liquid reservoir (4), the admission line (5) being connected to the at least one gas inlet (7) and comprising at least one control valve (12); and an emission line (6) configured to withdraw the gaseous medium from the liquid reservoir (4), the emission line (6) being connected to the at least one gas outlet (8) and comprising at least one control valve (15). The present invention further relates to an assembly comprising said device, and to a method for providing a liquid medium with a controlled flow rate and with a controlled concentration in a dissolved gas.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT CURIE (France)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
Inventor
Bouquerel, Charlotte
César, William
Viovy, Jean-Louis
Gentric, Géraldine
Descroix, Stéphanie
Parrini, Maria-Carla
Mechta-Grigoriou, Fatima
Abstract
The invention relates to a method for monitoring at least one substance which may be produced or consumed by at least one living entity, and to an assembly for implementing the method. The method comprises flowing liquid medium having a controlled concentration of a dissolved gas and a controlled flow rate to a culture system (201) and taking at least one measurement within the culture system (201) so as to determine the presence, concentration or amount of the at least one substance in the liquid medium (205) in the culture system (201); and/or taking at least a first measurement upstream of the culture system (201) and a second measurement downstream of the culture system (201), and determining a concentration or amount of the substance consumed or produced by the at least one living entity based on the difference between the second measurement and the first measurement.
The present invention relates to an apparatus (100) for feeding a fluidic system (110) with liquid medium, the apparatus (100) comprising: - a recirculation input reservoir (120), an injection reservoir (130), a recirculation output reservoir (140) and a sampling reservoir (150), each reservoir comprising a gas inlet (160), and a liquid inlet (170) or liquid outlet (165) equipped with a check valve (175); - a refill channel (185) equipped with a check valve (186) from the input reservoir (120) to the recirculation output reservoir (140); - a pressure control unit (190) comprising gas lines connected to the gas inlets (160) of the reservoirs and configured to control gas pressure in the reservoirs; - the apparatus being configured to be connected to an inlet and an outlet of the fluidic system (110).
The present invention relates to an apparatus (100) for feeding a fluidic system (110) with liquid medium, the apparatus (100) comprising a manifold and a cartridge: wherein the cartridge comprises one or more reservoirs, each reservoir comprising: - at least one gas inlet, and - at least one liquid inlet or outlet; wherein the manifold comprises: - a pressure control unit comprising one or more gas lines; wherein the apparatus further comprises at least one connection configured to be connected to an inlet and/or an outlet of the fluidic system; wherein: - in a locked position, the cartridge is pressed against the manifold and the gas lines of the pressure control unit are connected to the gas inlets of the one or more reservoirs and are configured to control gas pressure in the one or more reservoirs; and - in an unlocked position, the cartridge is removable from the manifold.
The present invention relates to an apparatus (100) for feeding a fluidic system (110) with liquid medium, the apparatus (100) comprising a manifold and a cartridge removably mounted on the manifold: wherein the cartridge comprises one or more reservoirs, each reservoir comprising: - at least one gas inlet, and - at least one liquid inlet or outlet; wherein the manifold comprises: - a pressure control unit comprising one or more gas lines; - one or more magnetic field generators; wherein the apparatus further comprises at least one connection configured to be connected to an inlet and/or an outlet of the fluidic system; wherein, when the cartridge is mounted on the manifold: - the gas lines of the pressure control unit are connected to the gas inlets of the one or more reservoirs and are configured to control gas pressure in the one or more reservoirs; and - each magnetic field generator is configured to provide magnetic agitation in at least one of the reservoirs by generating a magnetic field in said reservoir.
The present invention relates to an apparatus (100) for feeding a fluidic system (110) with liquid medium, the apparatus (100) comprising a manifold and a cartridge removably mounted on the manifold; wherein the cartridge comprises one or more reservoirs, each reservoir comprising: wherein the cartridge comprises one or more reservoirs, each reservoir comprising: at least one gas inlet, and at least one liquid inlet or outlet; wherein the manifold comprises: a pressure control unit comprising one or more gas lines; one or more liquid level sensors; wherein the apparatus comprises at least one connection configured to be connected to an inlet and/or an outlet of the fluidic system; wherein, when the cartridge is mounted on the manifold: the gas lines of the pressure control unit are connected to the gas inlets of the one or more reservoirs and are configured to control gas pressure in the one or more reservoirs; and each liquid level sensor is configured to detect a level of liquid in at least one of the reservoirs.
The present invention relates to an apparatus for controlling pressure or flow in a fluidic system (110), the apparatus (100) comprising: - a main inlet/outlet (120); - a uni-directional pumping device (130) configured to pump gas from an inlet (133) of the pumping device (130) to an outlet (134) of the pumping device (130); - a valves array (140); and - a control unit (160); wherein the control unit (160) is configured to set the valves array (140) into at least two states comprising: a first state in which a first gas source (170) is fluidically connected to the inlet (133) of the pumping device (130), and the outlet (134) of the pumping device (130) is fluidically connected to the main inlet/outlet (120); and a second state in which the main inlet/outlet (120) is fluidically connected to the inlet (133) of the pumping device (130), and the outlet (134) of the pumping device (130) is fluidically connected to a second gas source (180).
The present invention relates to an apparatus (2) for controlling pressure or flow in a fluidic system (3), the apparatus (2) comprising: a first connection device (301) comprising a pumping device (304) and a main outlet (310); a second connection device (302) comprising a flow restriction (305); a third connection device (303) comprising a valve with a modifiable aperture (306); wherein the second connection device (302) and the third connection device (303) are connected to the first connection device (301) at a position between the pumping device (304) and the main outlet (310).
F04B 49/22 - Control of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for in, or of interest apart from, groups by means of valves
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT CURIE (France)
FLUIGENT (France)
Inventor
Cesar, William
Bouquerel, Charlotte
Verhulsel, Marine
Viovy, Jean-Louis
Descroix, Stéphanie
Abstract
The present invention relates to a device (2) for providing a liquid medium with a controlled flow rate and with a controlled concentration of a dissolved gas, the device (2) comprising: - a liquid reservoir (4) provided with: - at least one gas inlet (7); - at least one gas outlet (8); and - at least one liquid outlet (9); - an admission line (5) configured to provide a gaseous medium into the liquid reservoir (4), the admission line (5) being connected to the at least one gas inlet (7) and comprising at least one control valve (12); and an emission line (6) configured to withdraw the gaseous medium from the liquid reservoir (4), the emission line (6) being connected to the at least one gas outlet (8) and comprising at least one control valve (15). The present invention further relates to an assembly comprising said device, and to a method for providing a liquid medium with a controlled flow rate and with a controlled concentration in a dissolved gas.
Device for creating an emulsion consisting of a dispersed phase in the form of drops in a continuous phase, the device comprising:
a motion generator (11) in order to put into motion at least one first fluid (3) intended to form the dispersed phase;
a first channel (21) inside which the first fluid (3) put into motion can flow, the first channel (21) extending towards an output orifice (23) through which the first fluid is injected into at least one second fluid (5) intended to form the continuous phase;
a variation system (40) for varying the internal volume (Vi) of the first channel (21) over time.
The invention relates to a device for creating an emulsion consisting of a dispersed phase in the form of drops in a continuous phase, the device comprising: - a motion generator (11) for setting in motion at least one first fluid (3) intended for forming the dispersed phase, - a first channel (21) inside which the first fluid (3) set in motion can flow, the first channel (21) extending to an outlet opening (23) through which the first fluid is injected into at least one second fluid (5) intended for forming the continuous phase, - a variation system (40) for varying the internal volume (Vi) of the first channel (21) over time.
Microfluidic device comprising a tank (6) supplying a microchannel (2) with a first fluid (S), and a circuit (8) in which a flow of a second fluid can be established without contact with the microchannel (2). The circuit (8) passes through the tank (6) or is connected to the tank (6) by a pipe (30). The circuit (8) comprises a first on/off valve (12) mounted in parallel with a first proportional valve (11), these first valves (11, 12) being controllable so as to modify the pressure applied in the tank (6) to the first fluid (S) by the second fluid.
A microfluidic device comprising a tank (6) supplying a microchannel (2) with a first fluid (S), and a circuit (8) in which a flow of a second fluid can be established without contact with the microchannel (2). The circuit (8) passes through the tank (6) or is connected to the tank (6) by a pipe (30). The circuit (8) comprises a first on/off valve (12) mounted in parallel with a first proportional valve (11), these first valves (11, 12) being controllable in such a way as to modify the pressure applied in the tank (6) by the second fluid to the first fluid (S).
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6) (France)
Inventor
Goulpeau, Jacques
Le Nel, Anne
Lemang, Coline
Mathys, Lionel
Viovy, Jean-Louis
Taniga, Velan
Autebert, Julien
Malaquin, Laurent
Abstract
The invention relates to a system comprising: - at least one microfluidic device (1), - at least one duct (3) in fluidic connection with the microfluidic device (1), and - at least one vibrating element (8) connected to the duct (3) and adapted to transmit mechanical vibrations to the duct (3). The invention also relates to a method of performing an assay which be implemented using this system.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Apparatus for checking (inspecting) microflux pressure and
flow; laboratory apparatus for flux or pressure control;
dosage dispensers; electronic signal emitting/receiving
apparatus; micrometric systems; computer software for
analyzing in fiber optics, computer software for
electrochemical analysis; computer software for analyzing
voltage and temperature; computer software for pressure
sensors and microflux flow, all the aforesaid goods
exclusively for pressure control or flux control systems,
with the exception of cellular sorting and/or flux
cytometry. Medical apparatus and instruments for flux diagnostics, with
the exception of cellular sorting and/or flux cytometry;
electrodes for medical use. Design and development of computer software for pressure and
microflux flow sensors.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Apparatus for checking and inspecting microflux pressure and flow of fluids; laboratory apparatus for flux and pressure control of fluids; dosage dispensers, namely, machines for controlling, regulating and measuring the flow of fluids; electronic signal transmitting and receiving apparatus for controlling, regulating and measuring the flow of fluids; micrometric measuring systems comprised of micrometer gauges; downloadable computer software for analyzing data in the field of fiber optics; downloadable computer software for electrochemical analysis of data in the field of electrochemistry; downloadable computer software for analyzing voltage and temperature data in the field of physics; downloadable computer software for monitoring pressure sensors and microflux flow of fluids in the field of physics, all the aforesaid goods exclusively for pressure control and flux control systems, not being for cellular sorting and flux cytometry Medical apparatus and instruments for flux diagnostic of fluids in the field of physics, chemistry and biology, not being for cellular sorting and flux cytometry; electrodes for medical use [ Design and development of computer software for controlling, regulating and measuring pressure and microflux flow sensors ]
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (France)
FLUIGENT (France)
Inventor
Viovy, Jean-Louis
Saias, Laure
Goulpeau, Jacques
Saliba, Antoine-Emmanual
Malaquin, Laurent
Abstract
An integrated microsystem, comprising: a microchannel, a field generator to create a magnetic field in at least one first portion of the microchannel having a direction substantially collinear with the direction of flow in the portion of the microchannel, the magnetic field also presenting a gradient, wherein the microsystem additionally comprises a detection area in fluid connection with the microchannel,