The present invention relates to the field of pesticides, and relates to a herbicidal composition and a use thereof. The herbicidal composition comprises active ingredients including flufenacet and oxadiargyl, wherein the mass ratio of flufenacet to oxadiargyl is (0.13-12):1. The combination of oxadiargyl and flufenacet in the present invention can enhance control efficacy against resistant weeds, extend the weed-controlling spectrum, reduce the dosage of oxadiargyl, improve the safety, and can also solve the problem of poor drug efficacy of oxadiargyl at a low temperature, prolonging the lasting period. In addition, a combination of two herbicides having different action mechanisms can delay the development of weed resistance. The composition has advantages of high herbicidal efficacy, good safety, strong adaptability and environmental friendliness.
Provided by the present invention are a novel halogenated conjugated diene compound 1, a preparation method therefor and use thereof. The compound 1 can be obtained by subjecting a conjugated diene compound as a raw material to halogenation. 2-arylmalonic acid derivative obtained by subjecting compound 1 to dehydrohalogenation and aromatization can be applied to the synthesis of biologically active compounds. The present invention has the following significant features and advantages: (1) the present invention provides a novel halogenated conjugated diene compound 1 and a synthesis method therefor; and (2) this kind of multifunctional novel compounds 1 can be used to synthesize other compounds of significant value by means of further functionality conversion reactions.
C07C 255/31 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
C07C 255/33 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
3.
CONJUGATED TRIENE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Provided are a novel conjugated triene compound 1, a preparation method therefor and use thereof. The conjugated triene compound 1 is obtained by successively subjecting a 2-(cyclohexenylene) malonic acid derivative compound as a raw material to an isomerization reaction, a halogenation reaction in the presence of a halogenating reagent, and a dehydrohalogenation reaction at a certain temperature. A 2-aryl malonic acid derivative, obtained from the conjugated triene compound 1 by means of an aromatization reaction, can be used in the synthesis of a compound with a biological activity. The present invention has the following significant characteristics and advantages: (1) the present invention provides a novel conjugated triene compound 1 and a synthesis method therefor; and (2) such a novel compound with multifunctional groups can be used to synthesize other compounds of importance by means of a further functional group conversion reaction.
C07C 255/31 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
C07C 255/33 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
4.
METHOD FOR PREPARING 2-ARYLMALONIC ACID DERIVATIVE, INTERMEDIATE, AND APPLICATION THEREOF
The present invention provides a method for preparing a 2-arylmalonic acid derivative, an intermediate, and an application thereof. In the method, a cyclohexadiene compound is taken as a raw material, and isomerization reaction, halogenating reaction in the presence of a halogenating agent, and dehydrohalogenation aromatization reaction at a certain temperature are performed sequentially to obtain a 2-arylmalonic acid derivative 3. Compared with the prior art, the following notable features and advantages are provided: (1) the reaction does not require expensive metal catalysts; (2) the reaction does not require use of strong bases having potential safety hazards; (3) the reaction is safe, conditions are mild, yield is high, costs are low, and the present invention is beneficial to industrial production.
C07C 67/30 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
C07C 69/612 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
C07C 255/34 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
C07C 255/31 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
C07C 253/30 - Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
5.
METHOD FOR PREPARING 2-ARYLMALONAMIDE AND APPLICATIONS OF METHOD
Provided are a method for preparing 2-arylmalonamide and applications of the method. The method uses 2-(cyclohexylene) malononitrile as raw material that undergoes an aromatization-hydrolysis reaction under the effects of an oxidizer and water to produce in one step 2-arylmalonamide. Compared with the prior art, the method provided in the present invention for preparing 2-arylmalonamide has the following significant characteristics and advantages: (1) a completely different synthesis strategy; (2) the raw material is simple and easy to obtain; (3) a high yield, and at the same time, with the use of an expensive metal catalyst avoided, inexpensiveness and suitability for industrial production.
C07C 233/11 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
6.
PROCESS FOR PREPARING OXADIAZACYCLO COMPOUND AND USE THEREOF
Provided are a process for preparing an oxadiazacyclo compound and the use thereof. An N-alkoxycarbonyl hydrazine is cyclized with a disubstituted ether under the action of an alkali to give an N-alkoxycarbonyl oxadiazacyclo compound, and the latter and an alkali are subjected to a deprotection reaction to give the oxadiazacyclo compound. The process uses a new N-protection strategy, such that not only is the use of an expensive protective reagent avoided, but the reaction yield is also improved. Moreover, the preparation process further has the following advantages: same contains less of the three wastes and is simple to operate, uses equipment which will not easily corrode, etc., and is favorable for industrial production.
Provided are a method for preparing a 2-(cyclohexenylene) malonic acid derivative and the use thereof. In the method, an olefin and a 2-substituted malonic acid derivative are used as raw materials and are subjected to a cyclization reaction in the presence of a catalyst so as to give the 2-(cyclohexenylene) malonic acid derivative. The method has the following features: (1) same is capable of synthesizing a 2-(2,6-disubstituted cyclohexenylene) malonic acid derivative very efficiently; and (2) same has a high reaction yield, mild conditions, less of the three wastes, and is favourable for industrial production. More importantly, the 2-(cyclohexenylene) malonic acid derivative can be used in organic synthesis, and in particular, can be used in the synthesis of 2-aryl malonic acid derivatives and the corresponding drugs, such as the herbicide pinoxaden.
C07C 67/22 - Preparation of carboxylic acid esters by conversion of a group containing nitrogen into an ester group from nitriles
C07C 13/20 - Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a six-membered ring with a cyclohexene ring
A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Provided are a synthetic method for a 1,2,4-triazole-3-thione compound and an intermediate thereof. The method comprises reacting hydrazine as a raw material with glyoxylic acid to obtain a hydrazono acetic acid intermediate, and then reacting the latter with thiocyanate to obtain the target product. The method has readily available raw materials, a specific regioselectivity, fewer by-products and a high yield; there are no special requirements for the equipment, and there is no need for a high vacuum and a high temperature or anhydrous oxygen-free operations; and the process is simple, produces less of the three wastes, and is suitable for industrial production.
A synthesis method and intermediate for prothioconazole and enantiomer thereof. The method comprises: reacting a hydrazine with a glyoxylic acid to obtain a hydrazono-acetic acid intermediate, and reacting the intermediate with a thiocyanate to obtain a prothioconazole target product. The method is highly selective of reaction areas, generates little by-products, and has a high yield. The method does not have a high equipment requirement and does not need water-free or oxygen-free techniques. The method has simple techniques, generates little gas, liquid, or solid wastes, and is applicable for industrial production.
A method for preparing a high-purity sulfonamide compound, and an intermediate of the sulfonamide compound. The method comprises the following steps: a first step: using a sulfonamide compound (I) crude product as a starting material, allowing the sulfonamide compound (I) crude product to react with a compound represented by formula (II) under the action of alkali and a catalyst, so as to synthesize an intermediate represented by formula (III); and allowing the compound represented by formula (III) to react with alkali or acid, so as to prepare a high-purity sulfonamide compound (I).
A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
11.
HALOGENATED SULFUR COMPOUND AND PREPARATION METHOD AND USE THEREOF
The present invention relates to a halogenated sulfur compound such as N-[(1-halogenated)-thiocyclobutyl]-succinimide and preparation method thereof. Disclosed is a catalytic application of such compounds in the reaction of sulfuryl chloride and organic amine to prepare sulfonamide. The disclosed catalytic reaction for preparing sulfonamide by the halogenated sulfur compounds requires a mild reaction condition and a short reaction time, and has a high yield. The present invention does not need to use hazardous chlorine gas, thus being safe and environmentally friendly, and has great application value.
Disclosed is a preparation method of triazolo pyrimidine sulfydryl compound, the method rearranging and substituting the compound represented by formula (II) under the action of alcohol and alkali to obtain triazolo pyrimidine sulfydryl compound represented by formula (I). The method expands the approach of the original preparation method and raw material sources, with no environmentally unfriendly by-products, and has a great industrial application value.
Disclosed is a method for preparing thiadiazolylamide compounds. 2-sulfinyl-5-(trifluoromethyl)-1,3,4-thiadiazole (II) and 2-sulfuryl--5- (trifluoromethyl)-1,3,4-thiadiazole (II') are mixed in mass ratio of 99:1-1:99 as mixed raw materials, and then the mixed raw materials and compound (III) are reacted in the solution of solvent and inorganic base at the temperature of -20-25 ℃ to obtain compound (I). The method disclosed by the invention is simple in the preparation of the mixed raw materials, convenient to operate, high in reaction speed and yield, less in 'three wastes', and suitable for industrial production.
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