Emory University Office of Technology Transfer

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IPC Class
C07C 215/70 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton 1
C07C 255/47 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems 1
C07C 271/34 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms 1
C07C 307/02 - Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids 1
C07C 309/66 - Methanesulfonates 1
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1.

Modulators of liver receptor homologue 1 (LRH-1) and uses

      
Application Number 18764540
Grant Number 12415770
Status In Force
Filing Date 2024-07-05
First Publication Date 2024-11-07
Grant Date 2025-09-16
Owner Emory University, Office of Technology Transfer (USA)
Inventor
  • Ortlund, Eric
  • Mays, Suzanne
  • Jui, Nathan
  • Flynn, Autumn
  • Dugan, Michael

Abstract

This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.

IPC Classes  ?

  • C07C 59/54 - Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
  • C07C 35/50 - Alcohols with at least two rings
  • C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
  • C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
  • C07C 49/683 - Unsaturated compounds containing a keto group being part of a ring containing six-membered aromatic rings having unsaturation outside the aromatic rings
  • C07C 49/83 - Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
  • C07C 215/70 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
  • C07C 255/47 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
  • C07C 271/34 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
  • C07C 307/02 - Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
  • C07C 309/66 - Methanesulfonates
  • C07D 249/04 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles
  • C07F 9/09 - Esters of phosphoric acids
  • C07F 9/572 - Five-membered rings