The invention relates to a therapeutic composition comprising an inner portion and a biocompatible membrane fully or partially surrounding the inner portion. The biocompatible membrane comprises at least two layers: a first layer of a porous, nonwoven network of thermoplastic polyurethane polymer fibers formed by electrospinning and having a porosity of greater than or equal to 50%; an average pore diameter of less than 5 μm; and has a thickness in the range of 10 μm to 250 μm; and a second layer of a porous, nonwoven network of thermoplastic polymer fibers formed by electrospinning. The second layer has a mean average fiber diameter of the second layer is greater than the mean average fiber diameter in the first layer, and/or wherein the average pore diameter of the second layer is greater than the average pore diameter of the first layer. The inner portion comprises a therapeutic agent. The invention also relates to uses of the membrane and therapeutic composition, for instance, to encapsulate therapeutic cells.
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
Surgical implants; scaffolds, non-woven materials and
devices for implantation composed of artificial or synthetic
materials; medical devices; electrospun implants.
Surgical implants; scaffolds, non-woven materials and devices for implantation composed of artificial or synthetic materials; medical devices; electrospun implants.
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
Services relating to the custom manufacture of medical
devices for others; services relating to the custom coating
of medical devices, including surgical stents and scaffolds,
for others; services relating to the treatment of surgical
implants for others.
The Electrospinning Company Limited (United Kingdom)
Inventor
Mckean, Robert James
Bruti, Gianpaolo
Cirstea, Teodor-Matei
Thio, Marco
Behbehani, Mehri
Abstract
The invention relates to a fibrous composite material comprising a nonfibrous component having a water content of less than 10 wt. %; and a fibrous component comprising a porous scaffold of a plurality of electrospun polymeric fibers; wherein the nonfibrous component is a linear or branched, water-soluble, synthetic or natural polymer dispersed on the porous scaffold; and wherein at least 50% by weight of the fibrous composite material is the fibrous component. The fibrous composite material is useful in therapy, for instance, as a synthetic or substitute amniotic membrane. It may be used in the prevention and/or treatment of various trauma induced and chronic wounds and in ophthalmology.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
Custom manufacture of medical devices for others; Custom electrospun coating, custom dip coating, and custom electrospun and dip coating of medical devices, namely, surgical stents, synthetic vascular grafts, scaffolds, vascular occluders, structural heart devices, medical and implantable textiles, sutures and yarns, gynecology devices, drug delivery devices, catheters, clot retrieval devices and orthopedic implants, for others; Treatment of surgical implants for others
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Wound dressings; medicated materials for wound healing;
topical wound healing materials; scaffolds in the form of
non-woven membranes for healing wounds; medicated scaffolds. Cell culture apparatus and instruments for laboratory; cell
culture scaffolds in the form of non-woven membranes for
research and laboratory use. Surgical implants; therapeutic and prosthetic articles,
scaffolds and devices for implantation composed of
artificial or synthetic materials; medical devices;
implantable therapeutic devices containing cell cultures;
implantable devices for drug delivery; devices for drug
delivery in the form of compound releasing wound healing
membranes; cell culture articles (including membranes) for
medical use.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Wound dressings; medicated materials for wound healing;
topical wound healing materials; scaffolds in the form of
non-woven membranes for healing wounds; medicated scaffolds;
devices for drug delivery in the form of compound releasing
wound healing membranes. Cell culture apparatus and instruments for laboratory or
medical use; cell culture scaffolds. Surgical implants; therapeutic and prosthetic articles,
scaffolds and devices for implantation composed of
artificial or synthetic materials; medical devices;
implantable therapeutic devices containing cell cultures;
implantable devices for drug delivery.
The invention relates to a therapeutic composition comprising an inner portion and a biocompatible membrane fully or partially surrounding the inner portion. The biocompatible membrane comprises at least two layers: a first layer of a porous, nonwoven network of thermoplastic polyurethane polymer fibers formed by electrospinning and having a porosity of greater than or equal to 50%; an average pore diameter of less than 5 μm; and has a thickness in the range 10 to 250 μm; and a second layer of a porous, nonwoven network of thermoplastic polymer fibers formed by electrospinning. The second layer has a mean average fiber diameter of the second layer is greater than the mean average fiber diameter in the first layer, and/or wherein the average pore diameter of the second layer is greater than the average pore diameter of the first layer. The inner portion comprises a therapeutic agent. The invention also relates to uses of the membrane and therapeutic composition, for instance, to encapsulate therapeutic cells.
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
The invention relates to a fibrous composite material comprising a non-fibrous component having a water content of less than 10wt%; and a fibrous component comprising a porous scaffold of a plurality of electrospun polymeric fibres; wherein the non-fibrous component is a linear or branched, water-soluble, synthetic or natural polymer dispersed on the porous scaffold; and wherein at least 50% by weight of the fibrous composite material is the fibrous component. The fibrous composite material is useful in therapy, for instance, as a synthetic or substitute amniotic membrane. It may be used in the prevention and/or treatment of various trauma induced and chronic wounds, and in ophthalmology.
A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
A61L 27/50 - Materials characterised by their function or physical properties
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Wound dressings; medicated materials for wound healing namely medicated scaffolds and dressings; topical wound healing materials namely scaffolds; devices for drug delivery in the form of compound releasing wound healing membranes Cell culture apparatus and instruments for laboratory use, namely, cell culture non-woven materials and scaffolds for laboratory use; cell culture non-woven materials that can be used for cell culturing for the purposes of chemical analysis, biological analysis or scientific, laboratory use, namely cell culture scaffolds and non-woven substrates comprised of nanofibres or microfibres for tissue culture Surgical implants comprising artificial synthetic or other non-living natural ingredients for use as scaffolds; therapeutic and prosthetic articles, scaffolds and devices for implantation composed of artificial, synthetic or other non-living natural ingredients for medical therapy, repairing body tissue or wound healing; medical devices namely, non-woven materials composed of artificial, synthetic or other non-living natural ingredients for medical therapy, repairing body tissue or wound healing, namely cell culture scaffolds and non-woven substrates comprised of nanofibres or microfibres for tissue culture; implantable therapeutic devices containing cell cultures for medical therapy; implantable devices for drug delivery namely, non-woven materials composed of artificial, synthetic or other non-living natural ingredients which release compounds into the body that are sold empty
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Wound dressings; medicated materials for wound healing namely medicated scaffolds and dressings; topical wound healing materials namely scaffolds; devices for drug delivery in the form of compound releasing wound healing membranes Cell culture apparatus and instruments for laboratory use, namely, cell culture non-woven materials and scaffolds for laboratory use; cell culture non-woven materials that can be used for cell culturing for the purposes of chemical analysis, biological analysis or scientific, laboratory use, namely cell culture scaffolds and non-woven substrates comprised of nanofibres or microfibres for tissue culture Surgical implants comprising artificial synthetic or other non-living natural ingredients for use as scaffolds; therapeutic and prosthetic articles, scaffolds and devices for implantation composed of artificial, synthetic or other non-living natural ingredients for medical therapy, repairing body tissue or wound healing; medical devices namely, non-woven materials composed of artificial, synthetic or other non-living natural ingredients for medical therapy, repairing body tissue or wound healing, namely cell culture scaffolds and non-woven substrates comprised of nanofibres or microfibres for tissue culture; implantable therapeutic devices containing cell cultures for medical therapy; implantable devices for drug delivery namely, non-woven materials composed of artificial, synthetic or other non-living natural ingredients which release compounds into the body that are sold empty
The invention relates to a therapeutic composition (5, 6) comprising an inner portion (7) and a biocompatible membrane (4) fully or partially surrounding the inner portion. The biocompatible membrane comprises at least two layers: a first layer (1) of a porous, non-woven network of thermoplastic polyurethane polymer fibres formed by electrospinning and having a porosity of greater than or equal to 50%; an average pore diameter of less than 5pm; and has a thickness in the range 10 to 250pm; and a second layer (2) of a porous, non-woven network of thermoplastic polymer fibres formed by electrospinning. The second layer (2) has a mean average fibre diameter of the second layer (2) is greater than the mean average fibre diameter in the first layer (1), and/or wherein the average pore diameter of the second layer (2) is greater than the average pore diameter of the first layer (1). The inner portion (7) comprises a therapeutic agent (3). The invention also relates to uses of the membrane and therapeutic composition, for instance, to encapsulate therapeutic cells.
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D01D 5/00 - Formation of filaments, threads, or the like
The invention relates to a therapeutic composition (5, 6) comprising an inner portion (7) and a biocompatible membrane (4) fully or partially surrounding the inner portion. The biocompatible membrane comprises at least two layers: a first layer (1) of a porous, non-woven network of thermoplastic polyurethane polymer fibres formed by electrospinning and having a porosity of greater than or equal to 50%; an average pore diameter of less than 5pm; and has a thickness in the range 10 to 250pm; and a second layer (2) of a porous, non-woven network of thermoplastic polymer fibres formed by electrospinning. The second layer (2) has a mean average fibre diameter of the second layer (2) is greater than the mean average fibre diameter in the first layer (1), and/or wherein the average pore diameter of the second layer (2) is greater than the average pore diameter of the first layer (1). The inner portion (7) comprises a therapeutic agent (3). The invention also relates to uses of the membrane and therapeutic composition, for instance, to encapsulate therapeutic cells.
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D01D 5/00 - Formation of filaments, threads, or the like
15.
ELONGATE SCAFFOLD COMPRISING INNER AND OUTER PORTION
The invention relates to an elongate scaffold comprising: an inner portion comprising a polymer; and an outer portion comprising a porous, non-woven network of polymer fibres, wherein the packing density of the inner portion is greater than the packing density of the outer portion; wherein the inner portion (a) comprises a plurality of polymer fibres twisted around one another or (b) is a solid core comprising the polymer. The invention also relates to a scaffold precursor and a process for producing a scaffold, comprising twisting a scaffold precursor of the invention along its length. Further provided is a hybrid composition comprising the scaffold and cells and/or an active agent such as a drug, a nucleic acid, a nucleotide, a protein, a polypeptide or an exosome. Therapeutic methods and uses of such hybrid compositions are also provided, for instance in tissue repair, wound healing, and in the treatment of a cardiac, bone, cartilage, tendon, ligament, liver, kidney joint, spleen, eye, spinal disc, connective tissue, or lung injury or disease or cancer, or an infection in a patient, and as tissue fillers for reconstructive or cosmetic applications.
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
B32B 7/03 - Layered products characterised by the relation between layers Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties Layered products characterised by the interconnection of layers with respect to the orientation of features
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
Cell culture apparatus and instruments for laboratory;
laboratory apparatus and instruments, namely, discs and
sheets comprising polymer three-dimensional nano fibre
and/or micro fibre cell culture matrices for use in
laboratory and/or medical research; disposable plastic
bioreactors for cell culture, namely deep well plates. Surgical implants; therapeutic and prosthetic articles and
devices for implantation composed of artificial or synthetic
materials; cell culture apparatus and instruments for
medical use. Custom manufacture and assembly services relating to
electrospun products and/or the three-dimensional printing
of products; custom manufacture for others of wound
dressings, medical devices and medical device components;
the treatment, transformation and coating of [electrospun or
three-dimensionally printed] artificial articles and
materials for others for use as surgical implants, wound
dressings, medical devices and prosthetics; providing
information and advice relating to manufacturing processes
for custom manufactured products and materials.
40 - Treatment of materials; recycling, air and water treatment,
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Custom manufacture and assembly of electrospinning machines and apparatus and three-dimensional printers for others; custom manufacture for others of wound dressings, medical devices and medical device components; treatment of materials for others, namely, treatment of electrospun and three-dimensionally printed textile wound dressings and surgical implants comprising artificial material, medical devices and prosthetics all made of plastic, acrylic and synthetic resins; applying coatings ultrasonically to electrospun and three-dimensionally printed medical devices; providing information and advice in the field of manufacturing processes for custom manufactured products and materials Cell culture apparatus and instruments for laboratory use, namely, cell culture scaffold discs and sheets comprising polymer three-dimensional nanofibers and microfibers mounted in cell culture plates and bioreactors for laboratory use; laboratory apparatus and instruments for laboratory and medical research, namely, discs and sheets comprising polymer three-dimensional nanofiber and microfiber cell culture matrices being structural parts of bioreactors for cell culturing and medical laboratory research instruments for detecting pathogens and DNA analysis; disposable plastic bioreactors for cell culturing featuring deep well plates having multi-well arrays that can be used in chemical analysis, biological analysis or patterning for scientific, laboratory and medical research use Surgical implants comprising artificial electrospun material; therapeutic and prosthetic articles and devices for implantation comprising artificial electrospun material
The invention provides a microscaffold comprising a porous particle, which particle: (a) comprises a three dimensional network of fibres, which fibres comprise a polymer, and (b) has a particle size of less than or equal to 2000 μm. Further provided is a composition, which composition comprises a microscaffold of the invention or a plurality of microscaffolds of the invention. The invention also provides a multi-well assay plate comprising: a plurality of sample wells, and a composition of the invention in at least one of the sample wells. The microscaffold, composition or multi-well plate may be used for regenerative medicine, tissue engineering, screening compounds for biological use or drug screening. The microscaffold may further comprise a magnetic material, and the invention additionally provides a method of manipulating one or more such microscaffolds. The method comprises exposing a composition that comprises one or more such microscaffolds to a magnetic field of a magnet, and thereby causing the one or more microscaffolds in the composition to be attracted to said magnet by magnetic attraction..
09 - Scientific and electric apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell culture apparatus and instruments for laboratory or
medical use; laboratory apparatus and instruments, namely,
discs and sheets comprising polylactic acid three
dimensional nano fibre and/or micro fibre cell culture
matrices for use in laboratory and/or medical research; deep
well plates. Treatment of materials; material treatment involving cell
culture processes including scaffold treatment. Scientific services and research and design relating
thereto; industrial analysis and research services;
laboratory services including analysis, treatment and
research; biotechnology research; laboratory services
relating to the growth of cell cultures; testing
pharmaceutical, medical and biological agents for others;
consultancy services relating to the aforesaid.
The invention provides a multi-well assay plate, comprising: a plate base, which defines the bottom of a plurality of sample wells; a scaffold layer disposed on the plate base, which scaffold layer provides a porous three-dimensional network of polymer nanofibres in each of said sample wells; and a plate frame, which defines the side walls of said sample wells; wherein the plate frame is bonded to the plate base through the scaffold layer. The invention further provides a process for producing the multi-well assay plate. Further provided is a scaffold which comprises a porous three dimensional network of electrospun polymer nanofibres, wherein the mean diameter of the polymer nanofibres is from 500 nm to 10 μιη. A process for producing the scaffold is also provided, as are various uses of the multi-well plate and the scaffold in drug screening, regenerative medicine and tissue engineering.
40 - Treatment of materials; recycling, air and water treatment,
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
[ Treatment of materials by laser beam; material treatment of artificial scaffolds with, for example, gas plasma, gamma irradiation, extracellular matrix proteins for cultivating cellular cultures; material treatment of 3D electrospun fibre scaffolds to enhance cell adhesion and proliferation in 3D cellular cultures by modifying the surface chemistry and architecture of the scaffold using the aforementioned methods described ] Cell culture apparatus for laboratory use, namely, polylactic acid 3D nanofiber and microfiber cell culture scaffold discs and sheets mounted in cell culture plates and bioreactors; cell culture apparatus for medical use, namely, polylactic acid 3D nanofiber and microfiber cell culture scaffold discs and sheets mounted in cell culture plates and bioreactors; cell culture scaffolds, namely, polylactic acid electrospun nanofibre and microfibre substrates mounted with and without hanging-well-inserts used in laboratory research [ Scientific laboratory services, scientific research services and design of 3D electrospun fibre scaffolds for scientific purposes in the fields of tissue engineering, regenerative medicine, cell based drug discovery and cell based pharmacokinetic testing; scientific and medical laboratory services, including analysis of synthetic scaffold materials, cell-scaffold interactions and 3D cell cultures, and medical and scientific research in the field of cancer treatment and diagnosis; biotechnology research; laboratory services relating to the growth of 3D cell cultures; testing the efficacy and pharmacokinetic profiles of pharmaceutical, medical and biological agents for others; and scientific consulting and research services relating to the aforesaid ]
09 - Scientific and electric apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell culture apparatus and instruments for laboratory or medical use; cell culture scaffolds; deep well plates. Treatment of materials; material treatment involving cell culture processes including scaffold treatment. Scientific services and research and design relating thereto; industrial analysis and research services; laboratory services including analysis, treatment and research; biotechnology research; laboratory services relating to the growth of cell cultures; testing pharmaceutical, medical and biological agents for others; consultancy services relating to the aforesaid.
