Abstract

Nanopore-based scanning system including a probe structure comprising a nanopore: suction means configured to draw an end of a (bio)molecule inside the nanopore and inside the probe structure, single or multiple times; and displacement means configured to mechanically displace the probe structure and the nanopore relative to the one (bio)molecule along a direction following a direction of extension of the (bio)molecule while the (bio)molecule is located inside the nanopore and inside the probe structure, or configured to mechanically displace at least one support holding the (bio)molecule relative to the nanopore along a direction following a direction of extension of the (bio)molecule while holding the at least one support and while the (bio)molecule is located inside the nanopore.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

Herein described are diaryl ether compounds having the structure (I) Herein described are diaryl ether compounds having the structure (I) Herein described are diaryl ether compounds having the structure (I) as well as a method for their manufacture from lignin.

IPC Classes  ?

• C07C 43/205 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring

Abstract

The invention relates to a compound and use thereof for preventing and/or inhibiting bacterial adhesion to a non-living substrate or a living surface as well as for preventing and/or treating bacterial infection.

IPC Classes  ?

• A61P 31/04 - Antibacterial agents
• A61L 2/16 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor using chemical substances
• C07H 3/06 - Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Abstract

The present invention relates to methylmalonate (MMA)-based compounds for use in treating an inflammatory disease.

IPC Classes  ?

• A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• A61K 31/225 - Polycarboxylic acids
• A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

An intracorporeal robot (1) for deployment in a body tract, comprising: - a permanent magnet constituting an effector magnet (2) configured to be guided by an extracorporeal actuating magnet (105), and - a medical device (3) coupled to the effector magnet, the medical device comprising a shape memory structure (4) configured for tetherless actuation by an extracorporeal shape memory actuator (105).

IPC Classes  ?

• A61B 34/30 - Surgical robots
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 17/17 - Guides for drills
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
• A61B 10/02 - Instruments for taking cell samples or for biopsy

Abstract

22 separation, containing a porous single-layer graphene film. The method comprises the following steps: (a) providing a metal foil substrate; (b) preparing a porous single-layer graphene film on the metal foil substrate; (c) depositing a gas-permeable support film on top of the porous single-layer graphene film; (d) applying a layer of transfer release tape on top of the gas-permeable support film; and (e) removing, in particular delaminating, the metal foil substrate to obtain a gas separation membrane precursor. The gas separation membrane can be obtained from the gas separation membrane precursor. Also described is a gas separation membrane obtainable by the method according to the invention.

IPC Classes  ?

• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/02 - Inorganic material
• B01D 71/44 - Polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds, not provided for in a single one of groups

Abstract

Provided herein are dimerization pairs comprising a first and a second member, whereby interaction of the first and the second member of the dimerization pair can be disrupted by contacting the heterodimer with a small molecule. Also provided are heterodimers comprising the dimerization pairs disclosed herein as well as cells expressing the dimerization pairs and heterodimers disclosed herein. Also provided are methods of using the dimerization pairs, heterodimers, and cells, including for the treatment of disease.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 14/725 - T-cell receptors
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/775 - Apolipopeptides
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C07K 19/00 - Hybrid peptides
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61P 35/00 - Antineoplastic agents
• C07D 471/04 - Ortho-condensed systems

Abstract

A qubit device according to one aspect comprises: a semiconductor substrate; an elongate confinement arrangement; a first dielectric placed between the semiconductor substrate and the confinement arrangement to electrically separate the longitudinal confinement arrangement from the semiconductor substrate; a second dielectric longitudinally at least partially electrically insulating the confinement arrangement; a set of control gates arranged longitudinally along the confinement arrangement and separated from the confinement arrangement by the second dielectric. The control gates are configured to define one or more quantum dots in the confinement arrangement. A respective quantum dot is suitable for holding a spin qubit. The control gates comprise a set of first types of control gates and a set of second types of control gates arranged alternatingly along the confinement arrangement. The first types of control gates are ferromagnetic gates.

IPC Classes  ?

• H01L 29/423 - Electrodes characterised by their shape, relative sizes or dispositions not carrying the current to be rectified, amplified or switched
• H01L 29/12 - Semiconductor bodies characterised by the materials of which they are formed
• H01L 29/49 - Metal-insulator semiconductor electrodes
• H01L 29/775 - Field-effect transistors with one-dimensional charge carrier gas channel, e.g. quantum wire FET

Abstract

A method for volumetric manufacturing of a three-dimensional object, comprising the steps of spatially modulating a first optical beam (300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300) with a first spatial light modulator (310, 410, 510, 610, 710, 810, 910, 1010, 1110, 1210, 1310), to generate a first spatially modulated optical beam (320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320), and introducing said first modulated beam (320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320) at a first projection direction into a photosensitive resin (350, 450, 550, 650, 750, 850, 950, 1050, 1150, 1250, 1350) that is provided in a photosensitive resin container (340, 440, 540, 640, 740, 840, 940, 1040, 1140, 1240, 1340), so as to generate a three-dimensional light intensity distribution (360, 460c, 660, 760, 860, 1060, 1260) in said photosensitive resin (350, 450, 550, 650, 750, 850, 950, 1050, 1150, 1250, 1350), wherein the first spatially modulated optical beam provides time multiplexed pattern projections. The present invention is furthermore related to a device for performing said method.

IPC Classes  ?

• B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
• B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
• B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
• B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
• B29C 64/232 - Driving means for motion along the axis orthogonal to the plane of a layer
• B29C 64/236 - Driving means for motion in a direction within the plane of a layer
• B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor

Abstract

Disclosed herein are engineered progenitor cells and methods of using the same. Also disclosed herein are engineered cells differentiated from engineered progenitor cells of the present disclosure. Also disclosed herein are methods of treating a condition in a subject by administering an engineered progenitor cell or an engineered cell differentiated from an engineered progenitor cell of the present disclosure.

IPC Classes  ?

• A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
• A61K 38/20 - Interleukins
• A61K 40/19 - Dendritic cells
• A61K 40/24 - Antigen-presenting cells [APC]
• A61P 35/00 - Antineoplastic agents
• C12N 5/0784 - Dendritic cellsProgenitors thereof

Abstract

A data storage medium (2) comprising a stacked plurality of layers (9), each layer composed of a layer material selected from a group comprising at least two different dielectric materials, adjacent layers being formed of different materials, and at least one of the layers, that is not a top layer, constituting an information layer (9i) configured to be modified locally by energy from an electromagnetic beam (7) having a specific beam wavelength and a propagation direction (Z) transverse to the layers. The stacked plurality of layers include an aperiodic layer arrangement including at least three stacked adjacent layers having different thicknesses with respect to each other.

IPC Classes  ?

• G11B 7/24035 - Recording layers
• G11B 7/0045 - Recording

Abstract

The present invention provides methods of determining the risk to develop complications related to allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a biological sample isolated from a patient transplanted with allo-HSCT. The invention further provides therapeutic agents, kits and methods of treatment and/prevention of complications related to allo-HSCT.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

Ferroelectric electro-optic modulator device comprising at least one supporting substrate or layer, at least one supporting oxide material or layer, at least one ferroelectric material or layer wherein the at least one ferroelectric material or layer includes or delimits at least one elongated waveguide core of at least one elongated waveguide, at least one intermediate layer comprising or consisting of at least one polycrystalline silicon layer or material provided or deposited between the at least one supporting oxide material or layer and the at least one supporting silicon substrate or layer, and a plurality of metal electrodes.

IPC Classes  ?

• G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure
• G02F 1/05 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect with ferro-electric properties

Abstract

Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/28 - Insulins
• A61K 38/38 - Albumins
• A61K 39/35 - Allergens
• A61K 39/385 - Haptens or antigens, bound to carriers
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound

Abstract

The present invention relates generally to the field of anti-cancer therapy and autoimmune therapy, in particular to the use of adoptive T cell transfer therapy. More specifically, the present invention relates to compositions, pharmaceutical compositions or methods using IL-4, a fragment or variant thereof, fused to a moiety, to increase the efficacy of an anti-cancer immunotherapy or an autoimmune therapy.

IPC Classes  ?

• A61K 38/20 - Interleukins
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/42 - Cancer antigens
• A61P 35/00 - Antineoplastic agents
• C07K 14/54 - Interleukins [IL]

Abstract

222, wherein X is a metal selected from a group consisting of alkali metals and alkaline earth metals, and Y is a metal selected from a group consisting of transition metals and lanthanides.

IPC Classes  ?

• B01J 27/24 - Nitrogen compounds
• B01J 35/33 - Electric or magnetic properties
• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• H01M 8/22 - Fuel cells in which the fuel is based on materials comprising carbon or oxygen or hydrogen and other elementsFuel cells in which the fuel is based on materials comprising only elements other than carbon, oxygen or hydrogen

Abstract

Photonic integrated circuit waveguide amplifier fabrication method comprising providing at least one support cladding material or layer supporting at least one silicon nitride material or layer and/or at least one embedding cladding material or layer comprising the at least one silicon nitride material or layer embedded inside the at least one embedding cladding material or layer; wherein the at least one silicon nitride material or layer (has a material or layer thickness that is less than or equal to 400nm and greater than or equal to 40nm; and carrying out rare-earth ion implantation, at rare-earth ion acceleration values between 0.01 MeV and 0.5 MeV, by ion irradiation of at least one surface of the at least one supported and/or embedded silicon nitride material or layer, the at least one rare-earth ion implanted silicon nitride material or layer defining a waveguide core of the waveguide amplifier.

IPC Classes  ?

• H01S 3/063 - Waveguide lasers, e.g. laser amplifiers
• H01S 3/16 - Solid materials
• H01S 3/17 - Solid materials amorphous, e.g. glass
• H01S 3/23 - Arrangement of two or more lasers not provided for in groups , e.g. tandem arrangement of separate active media

Abstract

The invention provides a neuromodulation/neurostimulation system (10) for stimulating sympathetic circuitry responsible for blood pressure control in a mammal with autonomic dysreflexia, said system (10) comprising: at least one control unit (12) configured and arranged to provide stimulation data, and at least one stimulation unit (14), operatively connected to the at least one control unit (12), said at least one stimulation unit (14) being configured and arranged to provide electrical stimulation to the spinal cord of said mammal, preferably at thoracic level, more preferably around spinal cord level T10-T12. The at least one stimulation unit (14) includes an implantable lead (18). The neuromodulation/neurostimulation system is configured and arranged to provide neuromodulation to said mammal to activate the sympathetic circuitry responsible for blood pressure control that mitigates autonomic dysreflexia.

IPC Classes  ?

• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

A combined neuromodulation and/or neurostimulation system for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system comprises: at least one Deep Brain Stimulation System for providing Deep Brain Stimulation to brain tissue of a subject, at least one control unit, configured and adapted to provide stimulation data, at least one stimulation unit, operatively connected to the at least one control unit, the at least one stimulation unit being configured and adapted to deliver epidural electrical stimulation to the dorsal side of the spinal cord of said subject, and at least one implantable pulse generator, wherein the at least one stimulation unit includes one or more electrodes configured to be implanted epidurally, the one or more electrodes being operatively connected to the at least one IPG.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

A 3T gain cell includes a write transistor, a storage transistor and a read transistor. The write transistor has a first diffusion connected to a write bit line (WBL), a gate connected to a write word line (WWL) and a second diffusion. The storage transistor has a gate connected to said second diffusion of said write transistor, a first diffusion connected to a read bit line (RBL), and a second diffusion. The read transistor has a gate connected to a read word line (RWL) a first diffusion connected to said second diffusion of said storage transistor, and a second diffusion connected to a reference voltage.

IPC Classes  ?

• G11C 11/405 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using semiconductor devices using transistors forming cells needing refreshing or charge regeneration, i.e. dynamic cells with charge regeneration common to a multiplicity of memory cells, i.e. external refresh with three charge-transfer gates, e.g. MOS transistors, per cell
• G11C 11/4093 - Input/output [I/O] data interface arrangements, e.g. data buffers
• G11C 11/4096 - Input/output [I/O] data management or control circuits, e.g. reading or writing circuits, I/O drivers or bit-line switches

Abstract

It is disclosed a method for manufacturing an electrically conductive metal trace (1) comprising depositing metal micro or nano particles (2) in or on a substrate (3); removing an oxide layer (4) around the particles; sintering the particles after oxide layer removal to form the electrically conductive metal trace (1). The method is characterized in that the step of removing the oxide layer is an electrochemical process wherein the metal micro or nano particles are contacted by a reducing agent (5), and the step of sintering is heat sintering induced by light (6). The method is particularly suitable for manufacturing a transient electrically conductive metal trace.

IPC Classes  ?

• C09D 11/52 - Electrically conductive inks
• C09D 11/037 - Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment
• H05K 1/02 - Printed circuits Details
• H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material

Abstract

A method for determining the functional topography of a peripheral nerve (10) of a user comprising the steps of prearranging an electrode (100) comprising a number n of channels ci, with i=1, 2 . . . , n, arranging the electrode (100) in such a way that each channel is in contact with the peripheral nerve (10) at a respective contact point pi, with i=1, 2 . . . , n, generating a model of a cross section S of the peripheral nerve (10) where the area A of the cross section S comprises a number m of areas aj, with j=1, 2, . . . , m, computing a lead field matrix L=[Rj,i], wherein Rj,i is a value that describes the electrostatic relationship between an area aj and a contact point pi of the cross section S, periodic acquisition, by the electrode (100), of a number n of voltage values Vki at instants tk, with k=1, 2, . . . , S, obtaining a voltage matrix V=[Vk,i], with i=1, 2, . . . , n, where Vki is the voltage value determined by the channel ci at the contact point pi at the instant tk, periodic acquisition, by at least one medical device, of a number r of values of physiological signals Pk,h of the user at instants tk, with k=1, 2, . . . , s, obtaining a matrix of the physiological signals P=[Pk,h], with h.=1, 2, . . . , r, where Pk k is the value of the h-th physiological signal determined at the instant tk, computing a discrimination matrix=D=[dh,i], D being function of the matrices V=[Vk,i] and P=[Pk,h], where dh,i is the discrimination coefficient which represents the correlation between the h-th physiological signal Pk,h and the i-th voltage value Vk,i referred to a same instant ty computing a spatial filtering matrix ΦDBF=[φh,j], φk,j being the localization index which represents the correlation between the h-th physiological signal and the area aj of said cross section S, generating a functional topography of said peripheral nerve (10), for each h-th physiological signal, wherein each area aj, is graphically identified as a function of the corresponding value φh,j associated with it by the spatial filtering matrix ΦDBF.

IPC Classes  ?

• A61B 5/294 - Bioelectric electrodes therefor specially adapted for particular uses for nerve conduction study [NCS]
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
• A61B 5/389 - Electromyography [EMG]

Abstract

The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includes a stimulation related basic data storage module for storing stimulation related basic data, a stimulation related response data storage module for storing the stimulation related response data, a transfer module configured such that the stimulation related basic data are linked with and/or translated into the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, and an analysis module configured and arranged such that the digital characteristic map is analyzed automatically.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

The present invention concerns a variable stiffness catheter (1) for surgical applications, a system (2) and a method for manufacturing said catheter, wherein said catheter (1) comprises at least one soft biocompatible hollow sleeve (S) and further including: - a tip sealing cap (10) at a distal end, - a working channel (15) enclosed within said sleeve (S) and extending from a proximal end to said distal end, for applying a treatment outside the catheter (1), through said tip sealing cap (10), - a plurality of fibers (F) enclosed within said sleeve (S), - an inlet attachable to a source (SV) of vacuum or pressure for applying vacuum or pressure inside said sleeve (S), said fibers (F) being assembled in at least one bundle such that applying vacuum inside said sleeve (S) induces fiber jamming resulting in a stiffening from a soft state to a stiff state.

IPC Classes  ?

• A61M 25/00 - CathetersHollow probes
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters

Abstract

Herein described is a method for making a composite material, comprising the steps of (a) swelling a blank hydrogel or a blank organogel using an inorganic precursor mixture to form an inorganic precursor-containing solvent-containing gel, wherein the inorganic precursor mixture comprises a solvent and one or more inorganic precursors, and (b) converting the inorganic precursor into ceramic or metal within the solvent-containing gel by introduction of reagents and/or stimuli to obtain a composite material. Optionally, the composite material can be converted into an inorganic material with an additional step (c) comprising thermally treating the composite material. Also described are the resultant composite material and the optional resultant inorganic material.

IPC Classes  ?

• C04B 35/624 - Sol-gel processing
• B22F 7/00 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting
• B22F 7/08 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting of composite workpieces or articles from parts, e.g. to form tipped tools with one or more parts not made from powder
• B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
• B33Y 40/20 - Post-treatment, e.g. curing, coating or polishing
• C04B 38/00 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof
• C04B 38/06 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof by burning-out added substances
• B22F 3/24 - After-treatment of workpieces or articles
• C08J 3/215 - Compounding polymers with additives, e.g. colouring in the presence of a liquid phase the polymer being premixed with a liquid phase at least one additive being also premixed with a liquid phase
• C01F 17/00 - Compounds of rare earth metals
• C01G 49/00 - Compounds of iron
• C08K 3/00 - Use of inorganic substances as compounding ingredients

Abstract

The present invention pertains to the field of biotechnology and bioengineering, specifically to the design and selection of multivalent binders for interrogating protein-protein interactions (PPIs). This invention focuses on novel methods for generating multivalent binders with user-defined spatial organization, using a combination of nucleic acid polymers and a target-tailored multimerization scaffold.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• C40B 40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof
• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G16B 35/20 - Screening of libraries
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Abstract

The present invention concerns a computer-system-implemented method for predicting properties of a protein molecule, comprising the steps of: receiving an input representation of the protein molecule; applying a surface generator to produce a molecular surface; applying at least one layer of geometric convolution on the molecular surface to produce a set of surface features; and using the set of features to predict the properties of the molecule.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G16B 15/20 - Protein or domain folding
• G16B 40/20 - Supervised data analysis

Abstract

A multimodal haptic device for rendering cutaneous and kinesthetic tactile cues of a target, including an actuator configured to contact a body part; a support movable unit, to move the actuator in one or an opposite direction of a force, the actuator including a contact region, configured to receive the force, and an adaptive region, around the contact region and substantially flat at rest; a controller configured to: set a first actuation input to raise the adaptive region relative to the contact region, wherein, in use, the haptic softness tactile cue is rendered by a surface of the raised adaptive region contacting the body part; drive the support movable unit to move the actuator in the one or opposite direction, the haptic kinesthetic tactile cue of the target rendered by another force applied to the body part by the actuator in the opposite direction.

IPC Classes  ?

• G08B 6/00 - Tactile signalling systems, e.g. personal calling systems

Abstract

Anion exchange membrane water electrolyzer flow field plate comprising a first flow entity configured to receive a fluid from at least one first flow entity fluid inlet and configured to communicate the fluid to at least one first flow entity fluid outlet; a second flow entity including at least one second flow entity fluid inlet and at least one second flow entity fluid outlet, the at least one second flow entity fluid inlet being configured to receive the fluid from the at least one first flow entity fluid outlet; an intermediate elongated rib located between and separating the first fluid flow entity and the second flow entity; and at least one further intermediate elongated rib delimiting or defining the at least one second flow entity fluid outlet, or an outlet support wall delimiting or defining the at least one second flow entity fluid outlet.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/77 - Assemblies comprising two or more cells of the filter-press type having diaphragms

Abstract

A method for reducing a preferred orientation of particles in a cryo-sample includes receiving the cryo-sample in a vacuum chamber, depositing amorphous ice onto the cryo-sample while the cryo-sample is in the vacuum chamber, delivering an energy pulse to the cryo-sample in the vacuum chamber to temporarily melt the amorphous ice on the cryo-sample to liquid water to promote movement of the particles in the cryo-sample to a changed orientation different from the preferred orientation, and allowing the liquid water to revitrify to amorphous ice upon cessation of the energy pulse to fix or trap the particles in the cryo-sample in the changed orientation.

IPC Classes  ?

• G01N 1/44 - Sample treatment involving radiation, e.g. heat
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

A thermal sensing device and a sensory feedback system and method using such thermal sensing device. The thermal sensing device including at least one film of electrically insulating polymer defining a global surface of the thermal sensing device and including at least one sensing track of a conducting material exhibiting a change in resistivity with temperature, said sensing track being arranged with a connection to at least one control module receiving the signal of the thermal sensing device as a measure of temperature, wherein said film further includes at least one heating track, powered by said control module to dissipate electrical power into heat within the thermal sensing device and maintain the sensing track at a determined baseline temperature.

IPC Classes  ?

• A61F 2/50 - Prostheses not implantable in the body
• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body

Abstract

1234567)12345671234567)12345677) is an amino acid selected from W, A T, R; and is preferably W; and (Y) is a Michael acceptor.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 14/81 - Protease inhibitors
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

Abstract

The present invention concerns an on-chip decoder (ocD), a brain implant, a prosthetic system and a method for decoding the task-related brain activity from multi-unit recordings of groups of neurons in a brain area and convert it into digital data usable by a classifier generating data labels corresponding to task-related information processed by said brain area, wherein said decoder uses multi-unit threshold crossing rates, called neural activity, subdivided into channels and time slots representing features of neural activity, in which it measures both the total magnitude and the uniformity of between-classes distances across all features to extract the most salient features and thereby generate a neural code (DNC) representing the highest class saliency values and reducing the neuronal state space into a low-dimensional DNC subspace, the parameters of the On-chip decoder (ocD) being computed offline during training and stored in an on-chip memory for online decoding.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body

Abstract

This disclosure describes a method for de novo bottom-up assembly and rational design of allosteric biosensors with programmable input-output behaviors that respond to soluble factors selectively enriched in tumors and trigger co-stimulation and cytokine signals. The disclosed method of effective mechanical coupling and biosensor signaling potency correlates with anti-tumor function. This disclosure provides synthetic biosensors with custom-built sensing and responses for basic and translational cell engineering applications.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 35/00 - Antineoplastic agents
• C07K 14/71 - ReceptorsCell surface antigensCell surface determinants for growth factorsReceptorsCell surface antigensCell surface determinants for growth regulators
• C07K 14/715 - ReceptorsCell surface antigensCell surface determinants for cytokinesReceptorsCell surface antigensCell surface determinants for lymphokinesReceptorsCell surface antigensCell surface determinants for interferons
• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction

Abstract

It is disclosed an implantable electrical/electronic biomedical device comprising: a) a reservoir (100) comprising an inlet (101) at a first end and a mechanical support (200) at a second, opposed end, and b) at least one electrode structure (300) deployable by eversion, said electrode structure (300) comprising: i) an elastic polymeric support (301) operatively connected to the reservoir's inlet (101) through a first end (302) and to the mechanical support (200) at a second end (303), and ii) at least one conductive track (400) disposed on a surface(S) of said elastic polymeric support (301).

IPC Classes  ?

• A61B 5/293 - Invasive
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The invention relates to chimeric antigen receptor constructs and their use for treatments and therapies. Further disclosed are methods of treating and/or preventing a disease, such as e.g. a cancer, an infectious disease, an inflammatory or inflammation-induced disease, a chronic disease or an autoimmune disease.

IPC Classes  ?

• C07K 14/54 - Interleukins [IL]
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/35 - Cytokines

Abstract

Compound of the general formula (Ia), (Ib) and (Ic) R50 and R60 are different form each other and are selected from the group consisting of —R70, —ZR70, —Z—OH, —Z—NH2, —Z—SH, —Z—OC(O)R70, —OC(O)R70, —COOH and its corresponding salts, —C(O)NH2, —C(O)NH—R70, —C(O)N—(R70)2, —COOR70, —Z—COOH and its corresponding salts, —Z—C(O)NH—R70, —Z—C(O)NH2, —Z—C(O)N—(R70)2, —Z—COOR70, —CH(COOH)2 and its corresponding salts, —CH(COOR70)2, and —Z—SO3— wherein R70 is selected from the group consisting of a linear or branched C1 to C20 alkyl, (C1 to C10)-alkyloxy-(C1 to C10)-alkyl, C2 to C10 alkenyl, C6 to C12 aryl, C3 to C10 cycloalkyl, cycloalkylalkyl and cycloalkylalkenyl, wherein Z is a linear or branched C1 to C10 alkyl, linear or branched C3 to C10 cycloalkyl, a linear or branched C6 to C10 aryl or a (C1 to C10)-alkyloxy-(C1 to C10)-alkyl, cycloalkylalkyl and cycloalkylalkenyl. Compound of the general formula (Ia), (Ib) and (Ic) R50 and R60 are different form each other and are selected from the group consisting of —R70, —ZR70, —Z—OH, —Z—NH2, —Z—SH, —Z—OC(O)R70, —OC(O)R70, —COOH and its corresponding salts, —C(O)NH2, —C(O)NH—R70, —C(O)N—(R70)2, —COOR70, —Z—COOH and its corresponding salts, —Z—C(O)NH—R70, —Z—C(O)NH2, —Z—C(O)N—(R70)2, —Z—COOR70, —CH(COOH)2 and its corresponding salts, —CH(COOR70)2, and —Z—SO3— wherein R70 is selected from the group consisting of a linear or branched C1 to C20 alkyl, (C1 to C10)-alkyloxy-(C1 to C10)-alkyl, C2 to C10 alkenyl, C6 to C12 aryl, C3 to C10 cycloalkyl, cycloalkylalkyl and cycloalkylalkenyl, wherein Z is a linear or branched C1 to C10 alkyl, linear or branched C3 to C10 cycloalkyl, a linear or branched C6 to C10 aryl or a (C1 to C10)-alkyloxy-(C1 to C10)-alkyl, cycloalkylalkyl and cycloalkylalkenyl.

IPC Classes  ?

• C07H 9/04 - Cyclic acetals
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/60 - SugarsDerivatives thereof
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61Q 19/00 - Preparations for care of the skin
• C07D 307/20 - Oxygen atoms
• C09K 23/32 - Heterocyclic compounds

Abstract

Systems and methods are provided for treating diseases that produce elevated pressure, e.g., intraocular pressure or cerebrospinal fluid pressure, such as glaucoma or hydrocephalus, wherein the device includes a housing shell, an elastic membrane, and a local constriction that reduces the area of the fluidic passageway through the housing shell and increases fluidic resistance of the flow of fluid through the passageway. At normal IOP levels, the elastic membrane engages the local constriction to prevent or reduce fluid flow across the passageway. When the average pressure between the inlet and outlet of the device varies, e.g., exceeds a predetermined threshold, the elastic membrane deforms and disengages the local constriction to thereby permit fluid flow across the passageway.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery
• A61M 27/00 - Drainage appliances for wounds, or the like

Abstract

The present invention relates to anti-tumor lymphocytes, and a variant cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution of one or both arginines at amino acid positions 255 and 236 and/or an amino acid substitution of one or both lysines at amino acid positions 254 and 258; or a nucleic acid molecule encoding said variant cGAS for use in the treatment of a tumor in a subject.

IPC Classes  ?

• A61K 38/45 - Transferases (2)
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention concerns a waveguide amplifier comprising: —at least one embedding cladding material or layer, and—at least one rare-earth ion implanted silicon nitride material or layer embedded in the at least one embedding cladding material or layer, the at least one rare-earth ion implanted silicon nitride material or layer defining a waveguide core enclosed by the at least one embedding cladding material or layer.

IPC Classes  ?

• H01S 3/063 - Waveguide lasers, e.g. laser amplifiers
• H01S 3/067 - Fibre lasers
• H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
• H01S 3/16 - Solid materials

Abstract

characterised bycharacterised by a distinct group size of consecutive intensity values; determining (23) a threshold value separating a background from candidate event intensity values; calculating (24) a dissolved intensity as a mean of the intensity values forming a background signal; carrying out (25) a first candidate event identification by obtaining candidate peak groups based on a feature characterising a respective group; carrying (26) out a second candidate event identification by obtaining ion cloud groups based on the threshold value; carrying out (27) a true event identification by comparing the first and second candidate event identifications to obtain one or more ion cloud group events for a respective group size; and summing (28) the intensity values of a respective ion cloud group event and subtracting the dissolved intensity as scaled from the summed intensity values of the respective ion cloud group event to obtain a total intensity value per particle or cell.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

Ion manipulation device for driving ions in a propulsion direction comprising an electrode support for supporting one or more electrodes; a first set of RF electrodes comprising a number n of electrodes, wherein the first set of RF electrodes comprises at least three electrodes; and an RF voltage generator operatively connected to the first set of RF electrodes. The RF voltage generator is configured to generate a plurality of phase-shifted RF voltages, each consecutive phase-shifted RF voltage of the generated plurality of phase- shifted RF voltages being phase-shifted by a value of approximately 2jt/n or 2jt/n to both confine ions in a first and/or second direction and to propel ions in the propulsion direction orthogonal or non-parallel to the first and/or second direction. The electrodes of the first set of RF electrodes are operatively connected to the RF voltage generator to simultaneously receive the plurality of phase-shifted RF voltages.

IPC Classes  ?

• H01J 49/06 - Electron- or ion-optical arrangements
• G01N 27/622 - Ion mobility spectrometry
• G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry

Abstract

The present invention relates to a computer-implemented method for engineering the interaction between a protein and a cognate peptide that are capable of forming a molecular complex, wherein the method comprises (a) preparing in silico a library of test peptides based on the cognate peptide, and the molecular complex of the protein and the cognate peptide; and/or (a′) preparing in silico a library of test protein scaffolds based at least on the parts of the protein that participate in forming the molecular complex with the cognate peptide; (b) docking in silico (i) the library of test peptides onto the library of protein scaffolds by modelling peptide-protein molecular complexes, or (ii) the cognate peptide on the library of protein scaffolds, or the library of test peptides onto the protein or the parts of the protein that participate in forming the molecular complex with the cognate peptide by modelling peptide-protein molecular complexes; (c) identifying the test peptides in the library and/or the protein scaffolds in the library for which low interface energy peptide-protein molecular complexes can be modelled, preferably by a combination of flexible peptide docking and/or de novo protein structure building; (d) identifying the interacting amino acids of the test peptides and/or the protein scaffolds in the ensemble of low interface energy modelled peptide-protein molecular complexes of step (c); (e) selecting and substituting in silico one or more of the interacting amino acids of the peptides and/or the protein scaffolds as identified in step (d) based on the ensemble of low interface energy peptide-protein molecular complexes as identified in step (c); and (f) generating in silico based on the peptides with substituted amino acid(s) and/or the protein scaffolds with substituted amino acid(s) of (e) an ensemble of peptides with substituted amino acid(s) and/or the protein scaffolds with substituted amino acid(s) for which the lowest interface energy peptide-protein molecular complexes can be modelled, thereby obtaining engineered peptides and/or proteins being capable of forming a molecular complex with engineered binding characteristics.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• C07K 14/52 - CytokinesLymphokinesInterferons
• C07K 14/715 - ReceptorsCell surface antigensCell surface determinants for cytokinesReceptorsCell surface antigensCell surface determinants for lymphokinesReceptorsCell surface antigensCell surface determinants for interferons
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

Our Ref.: 39418.EPF.P110PC Official file: tba December 20, 2024 - 51 - Abstract The present invention provides a system (100) for planning and/or providing control to neuro- modulation and/or neurostimulation and/or an actuator such as a brain computer interface (BCI) and/or providing a neural interface system, especially a brain-spinal-cord-interface sys- tem, the system (100) comprising: at least one input module (10) for brain signals (S), espe- cially raw brain signals (S); at least one pre-processing module (12) for converting the raw brain signals (S) into input tensors, wherein the input tensors include at least one of temporal and/or spatial and/or spectral information, and at least one conversion module (13) comprising an encoder and decoder network architecture (14), wherein the encoder and decoder network architecture (14) is configured to be trained by using partially masked samples of the input tensors to reconstruct electrical activity of a given representation of the input tensors, wherein a masking ratio is applied with positional embedding, which provides simultaneous learning of local and global features present in the brain data, thereby transforming the input tensors into a latent space. The invention further provides a method for planning neuromodulation and/or neurostimulation through the above-described system (100). (Fig. 1)

IPC Classes  ?

• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06N 3/045 - Combinations of networks
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Provided herein are heterodimeric proteins comprising a T cell receptor (TCR) and a dimerization motif. Also provided are immune cells expressing such heterodimeric proteins and the use of such heterodimeric protein and immune cells in adoptive cell transfer or adoptive cell therapy.

IPC Classes  ?

• C07K 14/725 - T-cell receptors
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61P 35/00 - Antineoplastic agents
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 19/00 - Hybrid peptides

Abstract

The present invention introduces a method for enhancing the selectivity of molecular interactions on biological interfaces by imposing a spatial geometry on nanoscale supports, referred to as nanostructures These nanostructures, designed as two- or three-dimensional platforms, comprise binding units present on the same plane with predetermined set angles or distances. The binding units, identical or of different identities, are strategically arranged to restrict spatial mobility. The method involves placing the nanostructures in contact with corresponding binding partners, allowing the organization of binding partners in the imposed spatial geometry. The invention provides a versatile approach applicable to various biological systems, offering precise control over molecular interactions at the nanoscale. Applications include targeted drug delivery, diagnostic assays, and molecular engineering.

IPC Classes  ?

• C12Q 1/6811 - Selection methods for production or design of target specific oligonucleotides or binding molecules

Abstract

A computer-implemented method includes accessing neural network (NN) components of a pre-trained analog-signal-based NN. The NN components are processed to generate scaled NN components. Based at least in part on one or more of the scaled NN components, temporal-coding-based NN components of a temporal-coding-based NN are generated. The temporal-coding-based NN components are dependent on the one or more of the scaled NN components.

IPC Classes  ?

• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs

Abstract

A computer-implemented method includes executing a spiking neural network (SNN) to perform an SNN task. The SNN includes accuracy-latency balance (ALB) characteristics that enable the SNN to perform the SNN task in a manner that achieves a predetermined ALB of an output generated by the SNN.

IPC Classes  ?

• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs
• G06N 3/0985 - Hyperparameter optimisationMeta-learningLearning-to-learn

Abstract

A cooling panel, particularly for cooling a condenser of a refrigeration system, the panel comprising a stack of a reflector top layer; a heat exchange layer; a hygroscopic evaporative bottom layer, wherein the reflector layer provides a radiative cooling of the heat exchange layer, and the evaporative layer provides evaporative cooling of said heat exchange layer, said heat exchange layer being internally traversed by a heat exchange medium.

IPC Classes  ?

• F24F 1/14 - Heat exchangers specially adapted for separate outdoor units
• F24F 5/00 - Air-conditioning systems or apparatus not covered by group or
• F25B 23/00 - Machines, plants or systems, with a single mode of operation not covered by groups , e.g. using selective radiation effect
• F25B 39/04 - Condensers

Abstract

A device (2) for use in optical image processing is disclosed. The device (2) comprises a medium (7) capable of supporting overlapping optical modes (10) such that, in response to spatially-structured illumination (4), a set of overlapping optical modes (10) in the medium (7) are non-uniformly excited and output a spatially-structured response (6).

IPC Classes  ?

• G06N 3/045 - Combinations of networks
• G06N 3/067 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using optical means
• G06N 3/084 - Backpropagation, e.g. using gradient descent

Abstract

The present invention generally relates to the field of intestinal health, disorders associated with aberrant microbiota and/or archaea-deficiency, and early-life immune system development. The present invention more specifically relates to M. smithii and components thereof for use as a biomarker, to methods for detecting M. smithii and/or for monitoring colonization status of M. smithii, biosensors and kits for detecting M. smithii or markers thereof, and M. smithii for promoting immune system homeostasis and intestinal health and for treating disorders associated with aberrant microbiota and/or archaea-deficiency.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• A61K 35/741 - Probiotics

Abstract

The invention concerns a device configured for electrophysiological analyses of biological entities such as for instance organoids and spheroids. The device comprises a passive first polymer layer (301), a hydrogel layer (302) capable of changing shape upon a trigger stimulus. An array of conductive tracks (400) and contact pads (401) may be used to contact the biological entity by triggering shape change of the hydrogel layer (302). The device may be arranged in a sample well.

IPC Classes  ?

• G01N 33/483 - Physical analysis of biological material
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A device for fragmenting ions by collision induced dissociation, the device intended to be used together with a planar ion mobility apparatus, the device including a first conductive grid having a plurality of first openings, the first conductive grid configured for electric interconnection to a first electric potential, and a second conductive grid having a plurality of second openings, the second conductive grid configured for electric interconnection to a second electric potential, the first and second conductive grids being electrically insulated from each other.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 27/622 - Ion mobility spectrometry
• H01J 49/02 - Particle spectrometers or separator tubes Details

Abstract

A luminescence spectroscopy apparatus for time-resolved characterization of a sample emitting circularly polarized light is described, comprising a pulsed laser excitation source configured to generate a laser pulse for exciting the sample, an achromatic quarter-wave plate arranged to receive therethrough light emitted by the sample, a polarization beam splitter arranged downstream to the quarter-wave plate, an optical spectrometer arranged downstream to the polarization beam splitter, a time-gated intensified charge-coupled device arranged to receive light from the optical spectrometer and comprising an image intensifier, and a controller configured to control a pulse generator to apply a gate pulse to the image intensifier for selectively activating the image intensifier, wherein the controller is connected to the pulsed laser excitation source such that the gate pulse is triggerable by the laser pulse of the pulsed laser excitation source.

IPC Classes  ?

• G01J 3/44 - Raman spectrometryScattering spectrometry
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/12 - Generating the spectrumMonochromators
• G01J 3/28 - Investigating the spectrum
• G01N 21/64 - FluorescencePhosphorescence

Abstract

A method of preparing a composition including crystalline particles of a halide perovskite, a composition and a perovskite-based device including the same. The halide perovskite has a chemical formula ABX3, wherein A is a monocation, B is selected from a combination of lead (II) and a dopant and X is selected from a halide.

IPC Classes  ?

• C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
• C01G 21/00 - Compounds of lead

Abstract

The invention relates to an optical nanomotion detection (ONMD) method for determining adhesion of one or more single living cells.

IPC Classes  ?

• G01N 19/04 - Measuring adhesive force between materials, e.g. of sealing tape, of coating
• G01N 15/1429 - Signal processing
• G01N 15/1433 - Signal processing using image recognition

Abstract

A closed-loop neuromodulation system, including an electrode array that is implantable to a brain of a subject, analog front-end device (AFD) for selectively selecting and reading a plurality of channels from electrode array, a finite impulse response (FIR) filter for selectively filtering signals from the AFD, a feature extraction engine (FEE) operatively connected to the FIR filter, configured to selectively extract features from signals provided by the FIR filter, a tree-structured hierarchical neural network classifier for detecting disease symptoms, and a multi-channel stimulator having high-voltage (HV) drivers operatively connectable to the electrode array.

IPC Classes  ?

• A61B 5/37 - Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG]
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/293 - Invasive

Abstract

The present invention relates to a method for the evolution of a protein of interest by applying light-based selection pressure to a yeast cell, (i) wherein in the yeast cell the expression of one or more gene(s) that encode a protein controlling the progression of the yeast cell through the cell cycle is/are optogenetically controlled by an optogenetic gene expression system that is activated by light pulses of a specific wavelength, and wherein the protein of interest is the protein or one of the proteins constituting the optogenetic gene expression system; or (ii) wherein in the yeast cell the expression of one or more gene(s) that encode a protein controlling the progression of the yeast cell through the cell cycle is/are controlled by the protein of interest or a signal transduction cascade that comprises the protein of interest, and wherein the expression of the protein of interest is optogenetically controlled by an optogenetic gene expression system that is activated by light pulses of a specific wavelength, wherein the method comprises (a) exposing the yeast cell to light pulses that differ from the light pulses that optimally activate gene expression but that still in part activate gene expression; (b) culturing the yeast cell contemporaneously under conditions where it divides and wherein random mutations are introduced for a time whereby a light-based selection pressure towards yeast cells being capable of optimally dividing under the light of (a) occurs, and (c) optionally isolating one or more yeast cells being capable of optimally dividing under the light pulses of (a) and preferably identifying the one or more mutation(s) in the gene encoding the protein of interest.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Abstract

The present invention relates to a method for analyzing cellular responsiveness to hormones or drags in a tissue sample based on an alginate-based 3D ex vivo culture system for normal and malignant tissue microstructures and uses thereof.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/09 - Tumour cells

Abstract

An optical interconnection device (1) comprising a plurality of input/output ports (2) comprising a plurality of receiving ports (2a) and a plurality of transmitting ports (2b), a light routing system (4) comprising at least one spatial light modulator (10) and a control system (20) configured to control the light routing system (4), wherein the optical interconnection device (1) is configurable to receive optical signals from the plurality of receiving ports (2a) and transmit said optical signals to the plurality of transmitting ports (2b) according to a first target set of interconnections comprising a first plurality of interconnections from at least one of the receiving ports (2a) to at least one of the transmitting ports (2b), wherein the control system (20) is configured to generate a first plurality of modulation patches (11) and display said first plurality of modulation patches (11) on the at least one spatial light modulator (10), wherein the first plurality of modulation patches (11) are configured to impose a plurality of successive spatial modulations on light beams (19) received by the receiving ports for routing said light beams (19) from the receiving ports (2a) to the transmitting ports (2b), thereby creating the first plurality of interconnections.

IPC Classes  ?

• H04B 10/80 - Optical aspects relating to the use of optical transmission for specific applications, not provided for in groups , e.g. optical power feeding or optical transmission through water
• H04Q 11/00 - Selecting arrangements for multiplex systems

Abstract

A fluid engaging device comprising a vortex mitigating component configured for integration in, or for assembly to, a vortex inducing zone of the fluid engaging device, the vortex mitigating component (2) comprising a vortex reducing structure (3) comprising at least one network (5, 5a, 5b) of interconnected5 tortuous channels bounded by an outer boundary (4) having at least a first surface portion (4a) and a second surface portion (4b), the network of interconnected channel sections (6) extending between inlet-outlet openings (7) positioned at the first surface portion to inlet-outlet openings positioned at the second surface portion such that fluid from outside of the outer boundary may flow through the inlet-outlet openings and channel sections between the first surface portion and second surface portion.

IPC Classes  ?

• F15D 1/00 - Influencing the flow of fluids
• F15D 1/12 - Influencing the flow of fluids around bodies of solid material by influencing the boundary layer
• F03D 1/06 - Rotors
• B64C 21/02 - Influencing air flow over aircraft surfaces by affecting boundary layer flow by use of slot, ducts, porous areas or the like
• B33Y 80/00 - Products made by additive manufacturing

Abstract

Method for determining an aggregation state of a solute in a solvent, comprising: illuminating (702), with a laser source, at least one mixture comprising the solute and the solvent with a pulsed laser beam, detecting (704), with a detector, a portion of the pulsed laser beam, wherein the portion of the pulsed laser beam has interacted with the at least one mixture, characterized in that detecting (704) a portion of the pulsed laser beam comprises: detecting non-resonant second harmonic photons, wherein the non-resonant second harmonic photons issue from an interaction of the pulsed laser beam with the solvent of the at least one mixture, and determining (706) at least one value indicative of the non-resonant second harmonic photons detected for the at least one mixture, and in that the method further comprises: determining (708) at least one characteristic for an aggregation behavior of the solute in the solvent on the basis of the at least one value indicative of the detected non-resonant second harmonic photons determined for the at least one mixture. A computer readable medium and an apparatus (300, 400, 500, 600) are described.

IPC Classes  ?

• G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
• G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials

Abstract

A computer-implemented insight extraction method, a data processing device and a system are proposed. The method provides a technical solution for proactive extraction of insights from human-to-human voice conversations on mobile and edge devices while preserving full privacy for the end user thanks to edge artificial intelligence technology. According to the method, users' data is processed directly on-device without the need for a connection to external, cloud-based services. An artificial Intelligence model based on compressed and optimised deep learning algorithm captures and interprets relevant information from the user data and uses this to trigger actions or build customisable reports.

IPC Classes  ?

• G06F 40/30 - Semantic analysis
• G06F 40/211 - Syntactic parsing, e.g. based on context-free grammar [CFG] or unification grammars
• G06F 40/35 - Discourse or dialogue representation

Abstract

A computer-implemented method for translating an input text element into a sequence of characters comprising a set of graphical symbols. The method comprises the steps of: selecting (12) one or more words out of the input text element as pre-processed or unprocessed to be translated to obtain a word selection; marking (12) the word selection; translating (13) the word selection identified by the marking into at least a set of graphical symbols by using an artificial intelligence language model considering the context of the word selection in the pre-processed text element to dynamically translate the word selection based on the context to obtain a translated word selection, wherein a given word in the word selection is translated into a sequence of at least two graphical symbols; and displaying (15) the input text element as translated to a user, wherein the input text element as translated comprises the translated word selection.

IPC Classes  ?

• G06F 40/274 - Converting codes to wordsGuess-ahead of partial word inputs
• G06F 40/279 - Recognition of textual entities

Abstract

The present invention relates to a polyaromatic polymer that comprises multifunctional aromatic moieties MA, cationic groups CG and bifunctional aromatic moieties BA, wherein one or more CG and one or more BA form a linear unit L, and MA is connected to 3 to 6 linear units L. MA, CG and BA are defined as described in the specification. Furthermore, the present invention relates to a neutral precursor of the polyaromatic polymer and to an anion exchange membrane that comprises a polyaromatic polymer according to the invention.

IPC Classes  ?

• B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01J 41/13 - Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
• B01J 47/12 - Ion-exchange processes in generalApparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
• C08G 61/10 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aromatic carbon atoms, e.g. polyphenylenes
• C08G 73/06 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromoleculePolyhydrazidesPolyamide acids or similar polyimide precursors
• C08J 5/22 - Films, membranes or diaphragms

Abstract

The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.

IPC Classes  ?

• A61L 27/56 - Porous or cellular materials
• A61L 27/22 - Polypeptides or derivatives thereof
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/38 - Animal cells
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

Methods for providing neuromodulation for spinal cord injury (SCI) treatment of a patient, comprising providing neuromodulation to a cervical spinal cord via at least one neuromodulator and at least one dorsal neuromodulation array for the SCI treatment; measuring movements and/or muscle activations of the patient via at least one sensor; and implementing a mapping between desired muscle activation patterns and neuromodulation parameters via at least one mapping module. Methods further comprise, via at least one processing module: processing signals provided by the at least one sensor, forwarding the processed signals to the at least one mapping module, and directing a mapping module output to the neuromodulator. In one or more examples, the neuromodulation is provided to the cervical spinal cord for the SCI treatment of a patient with an SCI condition.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

The present invention refers to a system for stimulation of the spinal cord for the rehabilitation of motor function in subjects with spinal cord injury or other motor disorders. Said system comprises a programmable implantable pulse generator (IPG), operatively connected to deliver current pulses to one or more multi-electrode arrays, wherein said IPG is adapted to deliver to said multi-electrode array a stimulation characterized by a frequency comprised between 20 and 1200 Hz and an amplitude comprised between 0.1 motor threshold amplitude and 1.5 motor threshold amplitude. The use of such system for facilitating locomotor functions or upper limb movements in a subject with neuromotor impairments is also within the scope of the invention.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A63B 22/02 - Exercising apparatus specially adapted for conditioning the cardio-vascular system, for training agility or co-ordination of movements with movable endless bands

Abstract

An electrostatic actuator for translational motion between a stator and a slider in a longitudinal direction (X), comprising a stator driving electrodes and slider driving electrodes arranged with a respective pitch along said direction (X), wherein said actuator is driven by n power supply outputs and the stator and/or slider driving electrodes are interconnected into n stator and/or slider power busses, characterised in that said slider and stator busses are such that the connection of the n stator busses is configured in a predetermined order, while the connection of the n slider busses are configured in a different predetermined order, each of said n power supply outputs are configurable to provide different phases of time-varying power allowing to create a first and a second potential distribution travelling over the pitch of the stator or slider driving electrodes, in the opposite direction to each other.

IPC Classes  ?

• H02N 1/00 - Electrostatic generators or motors using a solid moving electrostatic charge carrier

Abstract

The present invention concerns a structure (10) of architectured material for a mechatronic manipulator (1) and a mechatronic manipulator having one or more degrees of freedom by using such structure which comprises at least one hollow flexible unit (11) comprising at least one elastic deformable material, characterized in that said hollow flexible unit (11) comprises at least two first helicoids (H1) having a generatrix and a first twist direction and at least two second helicoids (H2) having a generatrix and a second twist direction opposite to the first twist direction, resulting in said first and second helicoids being intertwined, said intertwined helicoids being trimmed around their centers along a direction parallel to said generatrixes so as to form said hollow flexible unit (11) of trimmed helicoids.

IPC Classes  ?

• B25J 9/06 - Programme-controlled manipulators characterised by multi-articulated arms
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 18/02 - Arms extensible
• B25J 18/06 - Arms flexible

Abstract

The present invention relates to a system (100), especially a closed-loop system, for planning and/or providing neurostimulation/neuromodulation for enabling a body function, especially a motor function and/or autonomic function, and/or treatment of a body condition of a mammal, especially a human patient (P).

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/372 - Arrangements in connection with the implantation of stimulators
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

The invention relates to a gate unit (22) for controlling a gate commutated thyristor (21), comprising: —a voltage selector (26) for selectively applying a high supply potential (Vpos), a middle supply potential (Vmid), and a low supply potential (Vneg); —a nonlinear inductor (27) serially coupled between the output of the voltage selector (26); —a gate control unit (23) configured to control the voltage selector (26) to control switching of the gate commutated thyristor (21) in its turn-on state comprising a turn-on pulse generation, a positive-gate-voltage backporch operation, a negative-gate-voltage backporch operation and a retrigger pulse generation; wherein the nonlinear inductor (27) has a nonlinearity to have a high inductance during any of the backporch operations and to have a low inductance during the turn-on pulse generation and retrigger pulse generation.

IPC Classes  ?

• H03K 17/13 - Modifications for switching at zero crossing
• H02M 1/00 - Details of apparatus for conversion
• H02M 1/08 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters
• H02M 3/00 - Conversion of DC power input into DC power output
• H02M 3/315 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only

Abstract

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for dimensionality reduction of time-series using contrastive learning. A method can include receiving multidimensional input time series data that includes data from a session or sessions that span time, selecting positive samples and negative samples from the multidimensional input time series data for respective reference samples from the multidimensional input time series data, wherein the positive samples and negative samples are each selected with a respective predetermined distribution across the time of the session or sessions of the multidimensional input time series, and mapping the reference samples, the positive samples, and negative samples into a common embedding space.

IPC Classes  ?

• G06F 16/00 - Information retrievalDatabase structures thereforFile system structures therefor
• G06F 16/22 - IndexingData structures thereforStorage structures
• G06F 16/28 - Databases characterised by their database models, e.g. relational or object models

Abstract

A method and a setup for light detection and ranging are disclosed. The setup is configured to carry out the following method: generating signal radiation at multiple signal frequencies with an optical signal source, wherein the signal radiation exhibits random signal modulations preferably at each of the multiple signal frequencies, splitting the signal radiation into a target radiation part and a reference radiation part, directing the target radiation part towards a target, detecting a target signal, wherein the target signal is associated with a reflected portion of the target radiation part being reflected from the target, detecting a reference signal, wherein the reference signal is associated with the reference radiation part, and deriving at least one ranging information parameter from the target signal and the reference signal.

IPC Classes  ?

• G01S 7/4913 - Circuits for detection, sampling, integration or read-out
• G01S 7/481 - Constructional features, e.g. arrangements of optical elements
• G01S 7/4915 - Time delay measurement, e.g. operational details for pixel componentsPhase measurement
• G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging

Abstract

A force-feedback surface that creates and modulates distinctive profile and stiffness to interact with a user in contact thereto, the surface being functionally independent to be used as a single module but can be customized to extend the application in diverse fields by assembling in series, parallel, or any combinations to form a multimodular system.

IPC Classes  ?

• B25J 9/00 - Programme-controlled manipulators
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 9/16 - Programme controls

Abstract

12012020-hydrocarbyl alcohol, a base, and a catalyst in the presence of carbon dioxide and a reducing agent to a temperature of 20 to 250°C, wherein the catalyst comprises a metal of group VIIIB of the periodic table on an inorganic carrier, and wherein the carbon dioxide is present in gaseous form at a pressure of 5 to 100 bar. Also described is a method for preparing a catalyst comprising a metal of group VIIIB of the periodic table on a carrier, the method comprising a. preparing a solution of a salt of a metal of group VIIIB of the periodic table in a solvent, b. adding a reducing agent to the solution to obtain a treated solution, c. adding a carrier to the treated solution, d. removing the solvent to obtain a wet catalyst, and e. heating the wet catalyst to obtain the catalyst.

IPC Classes  ?

• B01J 29/12 - Noble metals
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/16 - Reducing
• C07C 67/00 - Preparation of carboxylic acid esters
• C07C 69/003 - Esters of saturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
• C07C 69/00 - Esters of carboxylic acidsEsters of carbonic or haloformic acids

Abstract

Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61K 9/107 - Emulsions
• A61K 9/51 - Nanocapsules
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 14/62 - Insulins
• C07K 14/74 - Major histocompatibility complex [MHC]
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 9/82 - Asparaginase

Abstract

The present invention concerns a method for producing at least one ferroelectric device or structure comprising the steps of providing at least one ferroelectric material or layer, or providing at least one ferroelectric material or layer to be patterned or structured; depositing at least one adhesion layer on a first side of the at least one ferroelectric material or layer; and depositing at least one diamond-like carbon layer or material on the at least one adhesion layer.

IPC Classes  ?

• G02B 6/136 - Integrated optical circuits characterised by the manufacturing method by etching
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02F 1/00 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

An apparatus for observing dynamic systems by time-resolved microscopy has an optical microscope including a cryo stage for receiving a cryo sample and maintaining the cryo sample at a cryogenic temperature, a heating system configured to temporarily heat at least a portion of the cryo sample such that the portion of the cryo sample melts to a liquid state, temporarily resides in the liquid state, and then revitrifies, and an image detector associated with the optical microscope for detecting magnified images of the cryo sample generated by the optical microscope. Detected images may be recorded and analyzed to inform on-the-fly adjustment of heating power level delivered to the cryo sample. In a correlative light-electron microscopy method, the revitrified cryo sample is observed using an electron microscope.

IPC Classes  ?

• G02B 21/30 - Base structure with heating device
• G02B 21/06 - Means for illuminating specimen
• G02B 21/26 - StagesAdjusting means therefor
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• H01J 37/22 - Optical or photographic arrangements associated with the tube
• H01J 37/26 - Electron or ion microscopesElectron- or ion-diffraction tubes

Abstract

Electronic metadevice comprising a conductive channel; a metal layer superposed on the conductive channel; and a barrier layer located between the metal layer and the conductive channel. The metal layer includes at least one recess extending through the metal layer to define at least one metallic metastructure comprising at least one first metal layer portion adjacent to at least one second metal layer portion. The recess extends through the metal layer to define a micro-structured or a nano-structured first metal layer portion comprising at least one first metallic extension or finger extending away from a first support of the first metal layer portion towards the second metal layer portion; and a micro-structured or a nano-structured at least one second metal layer portion comprising at least one second metallic extension or finger extending away from a second support of the second metal layer portion towards the first metal layer portion.

IPC Classes  ?

• H01L 29/41 - Electrodes characterised by their shape, relative sizes or dispositions
• H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
• H01L 29/417 - Electrodes characterised by their shape, relative sizes or dispositions carrying the current to be rectified, amplified or switched
• H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
• H01L 29/86 - Types of semiconductor device controllable only by variation of the electric current supplied, or only the electric potential applied, to one or more of the electrodes carrying the current to be rectified, amplified, oscillated, or switched

Abstract

The present disclosure relates to a microfluidic device comprising: a substrate; a culture chamber (130); a loading channel (170) in fluid communication with the culture chamber; at least one auxiliar channel (170-1, 5 170-2) extending from and in fluid communication with the loading channel, wherein the at least one auxiliary channel is so dimensioned such that a hydraulic resistance in the at least one auxiliary channel is higher than a hydraulic resistance in the loading channel; a test area (150) defined along the loading channel at a position between the loading channel and the at least one auxiliary channel; a first medium reservoir (110) in fluid communication with a first side of the test area; and a second medium reservoir (120) in fluid communication with a second side of the test area, the second side being different from the first side.

IPC Classes  ?

• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

1. The present invention relates to a method for preparing a catalyst comprising the steps of a. dissolving two or more alloy metal salts, b. adding at least one chelating agent and at least one stabilising agent, forming a sol, c. adding an encapsulant to said sol, d. evaporating said sol, forming a gel, e. drying said gel in the presence of oxygen, forming a powder, f. reducing said powder, forming a catalyst. The invention further relates to a catalyst, characterised in that the catalyst is stable for at least 200 h at a current density of 1.0 A/cm2. The invention further relates to catalyst comprising two or more metal alloys, wherein the two or more metal alloys are encapsulated by a metal oxide.

IPC Classes  ?

• B22F 1/16 - Metallic particles coated with a non-metal
• B01J 23/00 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group
• B01J 23/83 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with rare earths or actinides
• B01J 37/03 - PrecipitationCo-precipitation
• B01J 37/18 - Reducing with gases containing free hydrogen
• B22F 9/26 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions using gaseous reductors
• C22C 1/04 - Making non-ferrous alloys by powder metallurgy
• C22C 33/02 - Making ferrous alloys by powder metallurgy
• C25B 3/26 - Reduction of carbon dioxide
• C25B 11/069 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of at least one single element and at least one compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of two or more compounds
• C25B 11/089 - Alloys
• C25B 1/23 - Carbon monoxide or syngas
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 11/071 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of at least one single element and at least one compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of two or more compounds comprising metal or alloy powder and non-metallic binders
• C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide
• B01J 35/33 - Electric or magnetic properties

Abstract

121414323232453678234514614789143031303110213214111213131414 are independently selected from a hydrocarbon moiety with 1 to 10 carbon atoms; and n and p are independently from each other either 0 or 1.

IPC Classes  ?

• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 9/04 - Cyclic acetals

Abstract

ffWfWW ⋆WfWWW ⋆WWW ⋆WWW ⋆W Wff.

IPC Classes  ?

• H03M 13/00 - Coding, decoding or code conversion, for error detection or error correctionCoding theory basic assumptionsCoding boundsError probability evaluation methodsChannel modelsSimulation or testing of codes
• H03M 13/13 - Linear codes
• H03M 13/45 - Soft decoding, i.e. using symbol reliability information
• H04L 1/00 - Arrangements for detecting or preventing errors in the information received

Abstract

One aspect of the present invention proposes a method of predicting meteorological information by using an artificial deep neural network. The present invention according to one example focuses on image processing, specifically on fusing a plurality of images obtained by different webcams. It introduces a novel neural network architecture that combines a convolutional neural network (CNN) and long short-term memory (LSTM). The purpose of this fusion is to enhance the accuracy of predicting meteorological information compared to using a single image. By leveraging the capabilities of CNN and LSTM, the invention aims to improve the fusion process by extracting significant features from the images (such as clouds and shades) while considering the temporal aspect of the data.

IPC Classes  ?

• G01W 1/10 - Devices for predicting weather conditions
• G06N 3/0442 - Recurrent networks, e.g. Hopfield networks characterised by memory or gating, e.g. long short-term memory [LSTM] or gated recurrent units [GRU]
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06N 3/08 - Learning methods
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 20/70 - Labelling scene content, e.g. deriving syntactic or semantic representations

Abstract

A photonic assembly, a laser setup having the photonic assembly and a method for performing frequency-modulated continuous-wave light detection and ranging using the laser setup are disclosed. The photonic assembly has an active photonic chip, a photonic modulator chip, and a tuning arrangement having a modulation element having a thickness of 10 micrometers or less. The active photonic chip and the photonic modulator chip are optically coupled such, that injection radiation at an optical feedback wavelength is generated, which defines at least one optical lasing wavelength at which the optical radiation is emitted by the active photonic chip. The modulation element is arranged such, that an actuation of the modulation element tunes the optical feedback wavelength via the Pockels effect, such, that a tuning of the optical feedback wavelength entails a tuning of the optical lasing wavelength.

IPC Classes  ?

• G01S 7/4911 - Transmitters
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure

Abstract

A method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject includes: (a) determining the protein level of at least one protein in the sample of isolated cholesterol-rich lipoprotein nanoparticles; and (b) comparing the determined protein level to the corresponding protein level in one or more samples of cholesterol-rich lipoprotein nanoparticles obtained from one or more healthy subjects or a predetermined standard obtained from a corresponding protein level in one or more samples of cholesterol-rich lipoprotein nanoparticles obtained from one or more healthy subjects. An at least 1.5-fold increase or decrease of the determined protein level as determined in (a) as compared to the protein level in one or more samples of cholesterol-rich lipoprotein nanoparticles obtained from one or more healthy subjects or the predetermined standard indicates that the test subject has cancer.

IPC Classes  ?

• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention concerns a single-particle inductively-coupled plasma (ICP) mass spectrometry particle sizing and counting method comprising providing or receiving an intensity-versus-counts histogram of particles detected using an ICP mass spectrometer, the intensity representing particle detection and the count representing particle detection frequency; providing or receiving mass flux calibration data or calibration curve data relating a value of the intensity measurement or data of the ICP mass spectrometer to a mass of material detected per acquisition interval or dwell time; determining a particle mass of the particles detected using the mass flux calibration data or the at least one mass flux calibration curve data, determining a particle volume of the detected particles using the determined particle mass, and determining a particle size of the particles detected using the determined particle volume of the particles detected and a determined or attributed geometry or shape of the detected particles.

IPC Classes  ?

• G01N 15/10 - Investigating individual particles
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/10 - Ion sourcesIon guns

Abstract

Disclosed herein is a method of operating a microfluidic system, a microfluidic system for manipulating sample objects, and a control system for operating a microfluidic system. The method according to the invention is for operating a microfluidic system that comprises a manipulation zone for manipulating sample objects flowing through the manipulation zone, a first detection zone arranged upstream of or in the manipulation zone and a second detection zone arranged upstream of, in or downstream of the manipulation zone. A first count is determined that characterizes a number of sample objects flowing through the first detection zone. Sample objects are manipulated in the manipulation zone. A second count is determined that characterizes a number of sample objects flowing through the second detection zone. One or more manipulation parameters for manipulating the sample objects in the manipulation zone are adjusted based on the first count and the second count.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The disclosure concerns a steerable device for use as e.g. a guidewire for insertion into a subject's body. The device features a single side deflection of a bendable portion located at its distal end by application of a longitudinally-directed force either on an inner pull wire or on the bendable portion. The bendable portion is characterized by the presence of a reinforcement structure on one lateral side and a stress relief portion on the opposed lateral side that, upon actuation of the device, allows single side bending thanks to the physical constriction of the reinforcement structure, limiting the compression of one side of the bendable portion. The disclosure further concerns a system further comprising the steerable device and an actuator, as well as methods for using thereof.

IPC Classes  ?

• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 25/09 - Guide wires

Abstract

The invention provides fusion protein comprising a SCAN domain bearing member of a zinc finger-containing protein, a fragment or variant thereof and a catalytically inactive RNA- guided endonuclease or a DNA adenine methyltransferase. Preferably, the fusion protein is for use in the treatment and/or prevention of cancer, neurodegenerative disease, neurodevelopmental disease, aging and aging-related disease.

IPC Classes  ?

• C12N 15/62 - DNA sequences coding for fusion proteins
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 9/10 - Transferases (2.)
• C12N 9/22 - Ribonucleases

Abstract

The invention relates to use of an aerolysin nanopore for the discrimination of different protein isoforms bearing different post-translational modifications (PTMs) and to methods for detecting adverse medical conditions associated with the presence of peptides, polypeptides or proteins bearing particular PTMs.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

The present invention relates generally to the field of anti-cancer therapy, in particular to the use of adoptive T cell transfer therapy for treating cancer, in particular sold tumors. More specifically, the present invention relates to immune cells comprising one or more recombinant constructs, wherein at least one recombinant construct encodes an interleukin-10, a fragment or a variant thereof.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 38/20 - Interleukins
• A61P 35/00 - Antineoplastic agents
• C07K 14/725 - T-cell receptors
• C07K 16/22 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes

Abstract

The invention relates to a microfluidic device (3) comprising: —an inlet channel (31) having an inlet configured to be operatively connected with a droplet source (2) wherein the inlet channel (31) has a width wi and height hi; and —an outlet channel with at least one outlet channel branch (32) operatively connected with the inlet channel (31) at a passage point (33), said outlet channel (32) having a width wo, wherein the width wo of the at least one outlet channel branch (32) and the height hi and the width wi of the inlet channel (31) satisfy a geometrical condition of formula (I), said z>1.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A terahertz device for detecting or emitting or for both detecting and emitting electromagnetic waves in the terahertz frequency range. The terahertz device comprises: a first waveguide branch and a second waveguide branch, the first and second waveguide branches being configured to allow optical signals to propagate through them, the first and second waveguide branches being nonlinear dielectric elements with a thickness of at most 500 micrometres; and an antenna arrangement comprising a set of antennas for capturing and/or emitting electromagnetic waves in the terahertz frequency range, the antennas being placed along at least one of the waveguide branches in an immediate vicinity of the respective waveguide branch and/or around the respective waveguide branch to at least partially enclose the respective waveguide branch in a respective antenna gap of the respective antenna.

IPC Classes  ?

• H01Q 21/28 - Combinations of substantially independent non-interacting antenna units or systems
• H01L 23/66 - High-frequency adaptations
• H01Q 1/22 - SupportsMounting means by structural association with other equipment or articles

Abstract

A device (1) and method for processing data comprises at least one input layer (2), at least one modulation layer (3), and at least one output layer (4). The input layer (2) is configured to receive at least one carrier signal (Sc). The modulation layer (3) comprises input data. The modulation layer (3) is configured to modulate the carrier signal (Sc) such, that a modulated carrier signal (Smc) comprising the input data being linearly transformed is generated. The device (1) is configured such, that the modulated carrier signal (Smc) is repeatedly modulated with the input data and linearly transformed, wherein an output signal (So) comprising output data is produced at the output layer (4), and wherein the output data comprises or consists of the input data being nonlinearly processed.

IPC Classes  ?

• G02F 1/365 - Non-linear optics in an optical waveguide structure
• H04B 10/50 - Transmitters
• H04B 10/516 - Details of coding or modulation

Abstract

The present invention relates to a variant of cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution at one or more of (i) asparagine at amino acid position 513, (ii) asparagine at amino acid position 514, (iii) aspartic acid at amino acid position 465, (iv) glutamic acid at amino acid position 509, (v) tyrosine at amino acid position 510, (vi) arginine at amino acid position 512, (vii) lysine at amino acid position 427, and (viii) lysine at amino acid position 428. The present invention also relates to a variant of SplA/Ryanodine Receptor Domain And SOCS Box Containing 3 (SPSB3) carrying an amino acid substitution at one or more of (i) arginine at amino acid position 213, (ii) tyrosine at amino acid position 197, (iii) threonine at amino acid position 162, (iv) threonine at amino acid position 259, (v) arginine at amino acid position 262, (vi) serine at amino acid position 132, (vii) tyrosine at amino acid position 131, and (viii) tyrosine at amino acid position 160.

IPC Classes  ?

• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• A61K 38/00 - Medicinal preparations containing peptides
• C12P 19/30 - Nucleotides

Abstract

The invention relates to a dopant-free perovskite optoelectronic or photovoltaic device presenting molecular orbital stretching-junction, wherein the hole transport layer is a multilayer structure comprising at least two layers, each layer comprising a different hole transport material (HTM) having a different ionization energy (IP) for each layer and selected from donor material or acceptor material. The sequence of the layers in the multilayer structure of the hole transport layer is configured such that the layer of the hole transport layer in direct contact with the light-harvesting layer (4) is a layer comprising a donor material with an IP value being ≤-5.00 eV and ≥-5,60 eV, which is equal to or higher than the IP value of the organic/inorganic metal halide perovskite, the IP value of each HTM being lower than the work function of a material of the back contact or the counter electrode.

IPC Classes  ?

• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
• H10K 30/80 - Constructional details
• H10K 85/10 - Organic polymers or oligomers
• H10K 85/60 - Organic compounds having low molecular weight
• C07D 471/16 - Peri-condensed systems

Abstract

The present invention concerns a system for phenotypical profiling of at least one object and deterministic nanoliter-droplet encapsulation, comprising sample supplying means, buffer supplying means; a microfluidic chip comprising an encapsulation area or structure in which the object is encapsulated with a quantity of the reaction buffer by the droplet; detection means configured to detect the passage of the object through the first imaging chamber; at least one valve configured to stop the flow of the sample buffer when the detection means detect passage of the object through the first imaging chamber; phenotypical assessing means configured to assess the phenotype of the object when the flow of the sample buffer is stopped by the valve and the object is at an object stopping site; a droplet deposition means configured to deposit the droplet in a well or in a well of a multi-well plate and comprising an outlet capillary.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means