Abstract

A method for reducing a preferred orientation of particles in a cryo-sample includes receiving the cryo-sample in a vacuum chamber, depositing amorphous ice onto the cryo-sample while the cryo-sample is in the vacuum chamber, delivering an energy pulse to the cryo-sample in the vacuum chamber to temporarily melt the amorphous ice on the cryo-sample to liquid water to promote movement of the particles in the cryo-sample to a changed orientation different from the preferred orientation, and allowing the liquid water to revitrify to amorphous ice upon cessation of the energy pulse to fix or trap the particles in the cryo-sample in the changed orientation.

IPC Classes  ?

• G01N 1/44 - Sample treatment involving radiation, e.g. heat
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

A thermal sensing device and a sensory feedback system and method using such thermal sensing device. The thermal sensing device including at least one film of electrically insulating polymer defining a global surface of the thermal sensing device and including at least one sensing track of a conducting material exhibiting a change in resistivity with temperature, said sensing track being arranged with a connection to at least one control module receiving the signal of the thermal sensing device as a measure of temperature, wherein said film further includes at least one heating track, powered by said control module to dissipate electrical power into heat within the thermal sensing device and maintain the sensing track at a determined baseline temperature.

IPC Classes  ?

• A61F 2/50 - Prostheses not implantable in the body
• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body

Abstract

1234567)12345671234567)12345677) is an amino acid selected from W, A T, R; and is preferably W; and (Y) is a Michael acceptor.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 14/81 - Protease inhibitors
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

Abstract

The present invention concerns an on-chip decoder (ocD), a brain implant, a prosthetic system and a method for decoding the task-related brain activity from multi-unit recordings of groups of neurons in a brain area and convert it into digital data usable by a classifier generating data labels corresponding to task-related information processed by said brain area, wherein said decoder uses multi-unit threshold crossing rates, called neural activity, subdivided into channels and time slots representing features of neural activity, in which it measures both the total magnitude and the uniformity of between-classes distances across all features to extract the most salient features and thereby generate a neural code (DNC) representing the highest class saliency values and reducing the neuronal state space into a low-dimensional DNC subspace, the parameters of the On-chip decoder (ocD) being computed offline during training and stored in an on-chip memory for online decoding.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body

Abstract

This disclosure describes a method for de novo bottom-up assembly and rational design of allosteric biosensors with programmable input-output behaviors that respond to soluble factors selectively enriched in tumors and trigger co-stimulation and cytokine signals. The disclosed method of effective mechanical coupling and biosensor signaling potency correlates with anti-tumor function. This disclosure provides synthetic biosensors with custom-built sensing and responses for basic and translational cell engineering applications.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 35/00 - Antineoplastic agents
• C07K 14/71 - ReceptorsCell surface antigensCell surface determinants for growth factorsReceptorsCell surface antigensCell surface determinants for growth regulators
• C07K 14/715 - ReceptorsCell surface antigensCell surface determinants for cytokinesReceptorsCell surface antigensCell surface determinants for lymphokinesReceptorsCell surface antigensCell surface determinants for interferons
• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction

Abstract

It is disclosed an implantable electrical/electronic biomedical device comprising: a) a reservoir (100) comprising an inlet (101) at a first end and a mechanical support (200) at a second, opposed end, and b) at least one electrode structure (300) deployable by eversion, said electrode structure (300) comprising: i) an elastic polymeric support (301) operatively connected to the reservoir's inlet (101) through a first end (302) and to the mechanical support (200) at a second end (303), and ii) at least one conductive track (400) disposed on a surface(S) of said elastic polymeric support (301).

IPC Classes  ?

• A61B 5/293 - Invasive
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The invention relates to chimeric antigen receptor constructs and their use for treatments and therapies. Further disclosed are methods of treating and/or preventing a disease, such as e.g. a cancer, an infectious disease, an inflammatory or inflammation-induced disease, a chronic disease or an autoimmune disease.

IPC Classes  ?

• C07K 14/54 - Interleukins [IL]
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/35 - Cytokines

Abstract

Compound of the general formula (Ia), (Ib) and (Ic) R50 and R60 are different form each other and are selected from the group consisting of —R70, —ZR70, —Z—OH, —Z—NH2, —Z—SH, —Z—OC(O)R70, —OC(O)R70, —COOH and its corresponding salts, —C(O)NH2, —C(O)NH—R70, —C(O)N—(R70)2, —COOR70, —Z—COOH and its corresponding salts, —Z—C(O)NH—R70, —Z—C(O)NH2, —Z—C(O)N—(R70)2, —Z—COOR70, —CH(COOH)2 and its corresponding salts, —CH(COOR70)2, and —Z—SO3— wherein R70 is selected from the group consisting of a linear or branched C1 to C20 alkyl, (C1 to C10)-alkyloxy-(C1 to C10)-alkyl, C2 to C10 alkenyl, C6 to C12 aryl, C3 to C10 cycloalkyl, cycloalkylalkyl and cycloalkylalkenyl, wherein Z is a linear or branched C1 to C10 alkyl, linear or branched C3 to C10 cycloalkyl, a linear or branched C6 to C10 aryl or a (C1 to C10)-alkyloxy-(C1 to C10)-alkyl, cycloalkylalkyl and cycloalkylalkenyl. Compound of the general formula (Ia), (Ib) and (Ic) R50 and R60 are different form each other and are selected from the group consisting of —R70, —ZR70, —Z—OH, —Z—NH2, —Z—SH, —Z—OC(O)R70, —OC(O)R70, —COOH and its corresponding salts, —C(O)NH2, —C(O)NH—R70, —C(O)N—(R70)2, —COOR70, —Z—COOH and its corresponding salts, —Z—C(O)NH—R70, —Z—C(O)NH2, —Z—C(O)N—(R70)2, —Z—COOR70, —CH(COOH)2 and its corresponding salts, —CH(COOR70)2, and —Z—SO3— wherein R70 is selected from the group consisting of a linear or branched C1 to C20 alkyl, (C1 to C10)-alkyloxy-(C1 to C10)-alkyl, C2 to C10 alkenyl, C6 to C12 aryl, C3 to C10 cycloalkyl, cycloalkylalkyl and cycloalkylalkenyl, wherein Z is a linear or branched C1 to C10 alkyl, linear or branched C3 to C10 cycloalkyl, a linear or branched C6 to C10 aryl or a (C1 to C10)-alkyloxy-(C1 to C10)-alkyl, cycloalkylalkyl and cycloalkylalkenyl.

IPC Classes  ?

• C07H 9/04 - Cyclic acetals
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/60 - SugarsDerivatives thereof
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61Q 19/00 - Preparations for care of the skin
• C07D 307/20 - Oxygen atoms
• C09K 23/32 - Heterocyclic compounds

Abstract

Systems and methods are provided for treating diseases that produce elevated pressure, e.g., intraocular pressure or cerebrospinal fluid pressure, such as glaucoma or hydrocephalus, wherein the device includes a housing shell, an elastic membrane, and a local constriction that reduces the area of the fluidic passageway through the housing shell and increases fluidic resistance of the flow of fluid through the passageway. At normal IOP levels, the elastic membrane engages the local constriction to prevent or reduce fluid flow across the passageway. When the average pressure between the inlet and outlet of the device varies, e.g., exceeds a predetermined threshold, the elastic membrane deforms and disengages the local constriction to thereby permit fluid flow across the passageway.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery
• A61M 27/00 - Drainage appliances for wounds, or the like

Abstract

The present invention relates to anti-tumor lymphocytes, and a variant cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution of one or both arginines at amino acid positions 255 and 236 and/or an amino acid substitution of one or both lysines at amino acid positions 254 and 258; or a nucleic acid molecule encoding said variant cGAS for use in the treatment of a tumor in a subject.

IPC Classes  ?

• A61K 38/45 - Transferases (2)
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention concerns a waveguide amplifier comprising: —at least one embedding cladding material or layer, and—at least one rare-earth ion implanted silicon nitride material or layer embedded in the at least one embedding cladding material or layer, the at least one rare-earth ion implanted silicon nitride material or layer defining a waveguide core enclosed by the at least one embedding cladding material or layer.

IPC Classes  ?

• H01S 3/063 - Waveguide lasers, e.g. laser amplifiers
• H01S 3/067 - Fibre lasers
• H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
• H01S 3/16 - Solid materials

Abstract

characterised bycharacterised by a distinct group size of consecutive intensity values; determining (23) a threshold value separating a background from candidate event intensity values; calculating (24) a dissolved intensity as a mean of the intensity values forming a background signal; carrying out (25) a first candidate event identification by obtaining candidate peak groups based on a feature characterising a respective group; carrying (26) out a second candidate event identification by obtaining ion cloud groups based on the threshold value; carrying out (27) a true event identification by comparing the first and second candidate event identifications to obtain one or more ion cloud group events for a respective group size; and summing (28) the intensity values of a respective ion cloud group event and subtracting the dissolved intensity as scaled from the summed intensity values of the respective ion cloud group event to obtain a total intensity value per particle or cell.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

Ion manipulation device for driving ions in a propulsion direction comprising an electrode support for supporting one or more electrodes; a first set of RF electrodes comprising a number n of electrodes, wherein the first set of RF electrodes comprises at least three electrodes; and an RF voltage generator operatively connected to the first set of RF electrodes. The RF voltage generator is configured to generate a plurality of phase-shifted RF voltages, each consecutive phase-shifted RF voltage of the generated plurality of phase- shifted RF voltages being phase-shifted by a value of approximately 2jt/n or 2jt/n to both confine ions in a first and/or second direction and to propel ions in the propulsion direction orthogonal or non-parallel to the first and/or second direction. The electrodes of the first set of RF electrodes are operatively connected to the RF voltage generator to simultaneously receive the plurality of phase-shifted RF voltages.

IPC Classes  ?

• H01J 49/06 - Electron- or ion-optical arrangements
• G01N 27/622 - Ion mobility spectrometry
• G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry

Abstract

The present invention relates to a computer-implemented method for engineering the interaction between a protein and a cognate peptide that are capable of forming a molecular complex, wherein the method comprises (a) preparing in silico a library of test peptides based on the cognate peptide, and the molecular complex of the protein and the cognate peptide; and/or (a′) preparing in silico a library of test protein scaffolds based at least on the parts of the protein that participate in forming the molecular complex with the cognate peptide; (b) docking in silico (i) the library of test peptides onto the library of protein scaffolds by modelling peptide-protein molecular complexes, or (ii) the cognate peptide on the library of protein scaffolds, or the library of test peptides onto the protein or the parts of the protein that participate in forming the molecular complex with the cognate peptide by modelling peptide-protein molecular complexes; (c) identifying the test peptides in the library and/or the protein scaffolds in the library for which low interface energy peptide-protein molecular complexes can be modelled, preferably by a combination of flexible peptide docking and/or de novo protein structure building; (d) identifying the interacting amino acids of the test peptides and/or the protein scaffolds in the ensemble of low interface energy modelled peptide-protein molecular complexes of step (c); (e) selecting and substituting in silico one or more of the interacting amino acids of the peptides and/or the protein scaffolds as identified in step (d) based on the ensemble of low interface energy peptide-protein molecular complexes as identified in step (c); and (f) generating in silico based on the peptides with substituted amino acid(s) and/or the protein scaffolds with substituted amino acid(s) of (e) an ensemble of peptides with substituted amino acid(s) and/or the protein scaffolds with substituted amino acid(s) for which the lowest interface energy peptide-protein molecular complexes can be modelled, thereby obtaining engineered peptides and/or proteins being capable of forming a molecular complex with engineered binding characteristics.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• C07K 14/52 - CytokinesLymphokinesInterferons
• C07K 14/715 - ReceptorsCell surface antigensCell surface determinants for cytokinesReceptorsCell surface antigensCell surface determinants for lymphokinesReceptorsCell surface antigensCell surface determinants for interferons
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

Our Ref.: 39418.EPF.P110PC Official file: tba December 20, 2024 - 51 - Abstract The present invention provides a system (100) for planning and/or providing control to neuro- modulation and/or neurostimulation and/or an actuator such as a brain computer interface (BCI) and/or providing a neural interface system, especially a brain-spinal-cord-interface sys- tem, the system (100) comprising: at least one input module (10) for brain signals (S), espe- cially raw brain signals (S); at least one pre-processing module (12) for converting the raw brain signals (S) into input tensors, wherein the input tensors include at least one of temporal and/or spatial and/or spectral information, and at least one conversion module (13) comprising an encoder and decoder network architecture (14), wherein the encoder and decoder network architecture (14) is configured to be trained by using partially masked samples of the input tensors to reconstruct electrical activity of a given representation of the input tensors, wherein a masking ratio is applied with positional embedding, which provides simultaneous learning of local and global features present in the brain data, thereby transforming the input tensors into a latent space. The invention further provides a method for planning neuromodulation and/or neurostimulation through the above-described system (100). (Fig. 1)

IPC Classes  ?

• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06N 3/045 - Combinations of networks
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Provided herein are heterodimeric proteins comprising a T cell receptor (TCR) and a dimerization motif. Also provided are immune cells expressing such heterodimeric proteins and the use of such heterodimeric protein and immune cells in adoptive cell transfer or adoptive cell therapy.

IPC Classes  ?

• C07K 14/725 - T-cell receptors
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61P 35/00 - Antineoplastic agents
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 19/00 - Hybrid peptides

Abstract

The present invention introduces a method for enhancing the selectivity of molecular interactions on biological interfaces by imposing a spatial geometry on nanoscale supports, referred to as nanostructures These nanostructures, designed as two- or three-dimensional platforms, comprise binding units present on the same plane with predetermined set angles or distances. The binding units, identical or of different identities, are strategically arranged to restrict spatial mobility. The method involves placing the nanostructures in contact with corresponding binding partners, allowing the organization of binding partners in the imposed spatial geometry. The invention provides a versatile approach applicable to various biological systems, offering precise control over molecular interactions at the nanoscale. Applications include targeted drug delivery, diagnostic assays, and molecular engineering.

IPC Classes  ?

• C12Q 1/6811 - Selection methods for production or design of target specific oligonucleotides or binding molecules

Abstract

A computer-implemented method includes accessing neural network (NN) components of a pre-trained analog-signal-based NN. The NN components are processed to generate scaled NN components. Based at least in part on one or more of the scaled NN components, temporal-coding-based NN components of a temporal-coding-based NN are generated. The temporal-coding-based NN components are dependent on the one or more of the scaled NN components.

IPC Classes  ?

• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs

Abstract

A computer-implemented method includes executing a spiking neural network (SNN) to perform an SNN task. The SNN includes accuracy-latency balance (ALB) characteristics that enable the SNN to perform the SNN task in a manner that achieves a predetermined ALB of an output generated by the SNN.

IPC Classes  ?

• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs
• G06N 3/0985 - Hyperparameter optimisationMeta-learningLearning-to-learn

Abstract

A cooling panel, particularly for cooling a condenser of a refrigeration system, the panel comprising a stack of a reflector top layer; a heat exchange layer; a hygroscopic evaporative bottom layer, wherein the reflector layer provides a radiative cooling of the heat exchange layer, and the evaporative layer provides evaporative cooling of said heat exchange layer, said heat exchange layer being internally traversed by a heat exchange medium.

IPC Classes  ?

• F24F 1/14 - Heat exchangers specially adapted for separate outdoor units
• F24F 5/00 - Air-conditioning systems or apparatus not covered by group or
• F25B 23/00 - Machines, plants or systems, with a single mode of operation not covered by groups , e.g. using selective radiation effect
• F25B 39/04 - Condensers

Abstract

A device (2) for use in optical image processing is disclosed. The device (2) comprises a medium (7) capable of supporting overlapping optical modes (10) such that, in response to spatially-structured illumination (4), a set of overlapping optical modes (10) in the medium (7) are non-uniformly excited and output a spatially-structured response (6).

IPC Classes  ?

• G06N 3/045 - Combinations of networks
• G06N 3/067 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using optical means
• G06N 3/084 - Backpropagation, e.g. using gradient descent

Abstract

The present invention generally relates to the field of intestinal health, disorders associated with aberrant microbiota and/or archaea-deficiency, and early-life immune system development. The present invention more specifically relates to M. smithii and components thereof for use as a biomarker, to methods for detecting M. smithii and/or for monitoring colonization status of M. smithii, biosensors and kits for detecting M. smithii or markers thereof, and M. smithii for promoting immune system homeostasis and intestinal health and for treating disorders associated with aberrant microbiota and/or archaea-deficiency.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• A61K 35/741 - Probiotics

Abstract

The invention concerns a device configured for electrophysiological analyses of biological entities such as for instance organoids and spheroids. The device comprises a passive first polymer layer (301), a hydrogel layer (302) capable of changing shape upon a trigger stimulus. An array of conductive tracks (400) and contact pads (401) may be used to contact the biological entity by triggering shape change of the hydrogel layer (302). The device may be arranged in a sample well.

IPC Classes  ?

• G01N 33/483 - Physical analysis of biological material
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A device for fragmenting ions by collision induced dissociation, the device intended to be used together with a planar ion mobility apparatus, the device including a first conductive grid having a plurality of first openings, the first conductive grid configured for electric interconnection to a first electric potential, and a second conductive grid having a plurality of second openings, the second conductive grid configured for electric interconnection to a second electric potential, the first and second conductive grids being electrically insulated from each other.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• G01N 27/622 - Ion mobility spectrometry
• H01J 49/02 - Particle spectrometers or separator tubes Details

Abstract

A luminescence spectroscopy apparatus for time-resolved characterization of a sample emitting circularly polarized light is described, comprising a pulsed laser excitation source configured to generate a laser pulse for exciting the sample, an achromatic quarter-wave plate arranged to receive therethrough light emitted by the sample, a polarization beam splitter arranged downstream to the quarter-wave plate, an optical spectrometer arranged downstream to the polarization beam splitter, a time-gated intensified charge-coupled device arranged to receive light from the optical spectrometer and comprising an image intensifier, and a controller configured to control a pulse generator to apply a gate pulse to the image intensifier for selectively activating the image intensifier, wherein the controller is connected to the pulsed laser excitation source such that the gate pulse is triggerable by the laser pulse of the pulsed laser excitation source.

IPC Classes  ?

• G01J 3/44 - Raman spectrometryScattering spectrometry
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/12 - Generating the spectrumMonochromators
• G01J 3/28 - Investigating the spectrum
• G01N 21/64 - FluorescencePhosphorescence

Abstract

A method of preparing a composition including crystalline particles of a halide perovskite, a composition and a perovskite-based device including the same. The halide perovskite has a chemical formula ABX3, wherein A is a monocation, B is selected from a combination of lead (II) and a dopant and X is selected from a halide.

IPC Classes  ?

• C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
• C01G 21/00 - Compounds of lead

Abstract

The invention relates to an optical nanomotion detection (ONMD) method for determining adhesion of one or more single living cells.

IPC Classes  ?

• G01N 19/04 - Measuring adhesive force between materials, e.g. of sealing tape, of coating
• G01N 15/1429 - Signal processing
• G01N 15/1433 - Signal processing using image recognition

Abstract

A closed-loop neuromodulation system, including an electrode array that is implantable to a brain of a subject, analog front-end device (AFD) for selectively selecting and reading a plurality of channels from electrode array, a finite impulse response (FIR) filter for selectively filtering signals from the AFD, a feature extraction engine (FEE) operatively connected to the FIR filter, configured to selectively extract features from signals provided by the FIR filter, a tree-structured hierarchical neural network classifier for detecting disease symptoms, and a multi-channel stimulator having high-voltage (HV) drivers operatively connectable to the electrode array.

IPC Classes  ?

• A61B 5/37 - Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG]
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/293 - Invasive

Abstract

The present invention relates to a method for the evolution of a protein of interest by applying light-based selection pressure to a yeast cell, (i) wherein in the yeast cell the expression of one or more gene(s) that encode a protein controlling the progression of the yeast cell through the cell cycle is/are optogenetically controlled by an optogenetic gene expression system that is activated by light pulses of a specific wavelength, and wherein the protein of interest is the protein or one of the proteins constituting the optogenetic gene expression system; or (ii) wherein in the yeast cell the expression of one or more gene(s) that encode a protein controlling the progression of the yeast cell through the cell cycle is/are controlled by the protein of interest or a signal transduction cascade that comprises the protein of interest, and wherein the expression of the protein of interest is optogenetically controlled by an optogenetic gene expression system that is activated by light pulses of a specific wavelength, wherein the method comprises (a) exposing the yeast cell to light pulses that differ from the light pulses that optimally activate gene expression but that still in part activate gene expression; (b) culturing the yeast cell contemporaneously under conditions where it divides and wherein random mutations are introduced for a time whereby a light-based selection pressure towards yeast cells being capable of optimally dividing under the light of (a) occurs, and (c) optionally isolating one or more yeast cells being capable of optimally dividing under the light pulses of (a) and preferably identifying the one or more mutation(s) in the gene encoding the protein of interest.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Abstract

The present invention relates to a method for analyzing cellular responsiveness to hormones or drags in a tissue sample based on an alginate-based 3D ex vivo culture system for normal and malignant tissue microstructures and uses thereof.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/09 - Tumour cells

Abstract

An optical interconnection device (1) comprising a plurality of input/output ports (2) comprising a plurality of receiving ports (2a) and a plurality of transmitting ports (2b), a light routing system (4) comprising at least one spatial light modulator (10) and a control system (20) configured to control the light routing system (4), wherein the optical interconnection device (1) is configurable to receive optical signals from the plurality of receiving ports (2a) and transmit said optical signals to the plurality of transmitting ports (2b) according to a first target set of interconnections comprising a first plurality of interconnections from at least one of the receiving ports (2a) to at least one of the transmitting ports (2b), wherein the control system (20) is configured to generate a first plurality of modulation patches (11) and display said first plurality of modulation patches (11) on the at least one spatial light modulator (10), wherein the first plurality of modulation patches (11) are configured to impose a plurality of successive spatial modulations on light beams (19) received by the receiving ports for routing said light beams (19) from the receiving ports (2a) to the transmitting ports (2b), thereby creating the first plurality of interconnections.

IPC Classes  ?

• H04B 10/80 - Optical aspects relating to the use of optical transmission for specific applications, not provided for in groups , e.g. optical power feeding or optical transmission through water
• H04Q 11/00 - Selecting arrangements for multiplex systems

Abstract

A fluid engaging device comprising a vortex mitigating component configured for integration in, or for assembly to, a vortex inducing zone of the fluid engaging device, the vortex mitigating component (2) comprising a vortex reducing structure (3) comprising at least one network (5, 5a, 5b) of interconnected5 tortuous channels bounded by an outer boundary (4) having at least a first surface portion (4a) and a second surface portion (4b), the network of interconnected channel sections (6) extending between inlet-outlet openings (7) positioned at the first surface portion to inlet-outlet openings positioned at the second surface portion such that fluid from outside of the outer boundary may flow through the inlet-outlet openings and channel sections between the first surface portion and second surface portion.

IPC Classes  ?

• F15D 1/00 - Influencing the flow of fluids
• F15D 1/12 - Influencing the flow of fluids around bodies of solid material by influencing the boundary layer
• F03D 1/06 - Rotors
• B64C 21/02 - Influencing air flow over aircraft surfaces by affecting boundary layer flow by use of slot, ducts, porous areas or the like
• B33Y 80/00 - Products made by additive manufacturing

Abstract

Method for determining an aggregation state of a solute in a solvent, comprising: illuminating (702), with a laser source, at least one mixture comprising the solute and the solvent with a pulsed laser beam, detecting (704), with a detector, a portion of the pulsed laser beam, wherein the portion of the pulsed laser beam has interacted with the at least one mixture, characterized in that detecting (704) a portion of the pulsed laser beam comprises: detecting non-resonant second harmonic photons, wherein the non-resonant second harmonic photons issue from an interaction of the pulsed laser beam with the solvent of the at least one mixture, and determining (706) at least one value indicative of the non-resonant second harmonic photons detected for the at least one mixture, and in that the method further comprises: determining (708) at least one characteristic for an aggregation behavior of the solute in the solvent on the basis of the at least one value indicative of the detected non-resonant second harmonic photons determined for the at least one mixture. A computer readable medium and an apparatus (300, 400, 500, 600) are described.

IPC Classes  ?

• G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
• G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials

Abstract

A computer-implemented insight extraction method, a data processing device and a system are proposed. The method provides a technical solution for proactive extraction of insights from human-to-human voice conversations on mobile and edge devices while preserving full privacy for the end user thanks to edge artificial intelligence technology. According to the method, users' data is processed directly on-device without the need for a connection to external, cloud-based services. An artificial Intelligence model based on compressed and optimised deep learning algorithm captures and interprets relevant information from the user data and uses this to trigger actions or build customisable reports.

IPC Classes  ?

• G06F 40/30 - Semantic analysis
• G06F 40/211 - Syntactic parsing, e.g. based on context-free grammar [CFG] or unification grammars
• G06F 40/35 - Discourse or dialogue representation

Abstract

A computer-implemented method for translating an input text element into a sequence of characters comprising a set of graphical symbols. The method comprises the steps of: selecting (12) one or more words out of the input text element as pre-processed or unprocessed to be translated to obtain a word selection; marking (12) the word selection; translating (13) the word selection identified by the marking into at least a set of graphical symbols by using an artificial intelligence language model considering the context of the word selection in the pre-processed text element to dynamically translate the word selection based on the context to obtain a translated word selection, wherein a given word in the word selection is translated into a sequence of at least two graphical symbols; and displaying (15) the input text element as translated to a user, wherein the input text element as translated comprises the translated word selection.

IPC Classes  ?

• G06F 40/274 - Converting codes to wordsGuess-ahead of partial word inputs
• G06F 40/279 - Recognition of textual entities

Abstract

The present invention relates to a polyaromatic polymer that comprises multifunctional aromatic moieties MA, cationic groups CG and bifunctional aromatic moieties BA, wherein one or more CG and one or more BA form a linear unit L, and MA is connected to 3 to 6 linear units L. MA, CG and BA are defined as described in the specification. Furthermore, the present invention relates to a neutral precursor of the polyaromatic polymer and to an anion exchange membrane that comprises a polyaromatic polymer according to the invention.

IPC Classes  ?

• B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01J 41/13 - Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
• B01J 47/12 - Ion-exchange processes in generalApparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
• C08G 61/10 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aromatic carbon atoms, e.g. polyphenylenes
• C08G 73/06 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromoleculePolyhydrazidesPolyamide acids or similar polyimide precursors
• C08J 5/22 - Films, membranes or diaphragms

Abstract

The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.

IPC Classes  ?

• A61L 27/56 - Porous or cellular materials
• A61L 27/22 - Polypeptides or derivatives thereof
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/38 - Animal cells
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

Methods for providing neuromodulation for spinal cord injury (SCI) treatment of a patient, comprising providing neuromodulation to a cervical spinal cord via at least one neuromodulator and at least one dorsal neuromodulation array for the SCI treatment; measuring movements and/or muscle activations of the patient via at least one sensor; and implementing a mapping between desired muscle activation patterns and neuromodulation parameters via at least one mapping module. Methods further comprise, via at least one processing module: processing signals provided by the at least one sensor, forwarding the processed signals to the at least one mapping module, and directing a mapping module output to the neuromodulator. In one or more examples, the neuromodulation is provided to the cervical spinal cord for the SCI treatment of a patient with an SCI condition.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

The present invention refers to a system for stimulation of the spinal cord for the rehabilitation of motor function in subjects with spinal cord injury or other motor disorders. Said system comprises a programmable implantable pulse generator (IPG), operatively connected to deliver current pulses to one or more multi-electrode arrays, wherein said IPG is adapted to deliver to said multi-electrode array a stimulation characterized by a frequency comprised between 20 and 1200 Hz and an amplitude comprised between 0.1 motor threshold amplitude and 1.5 motor threshold amplitude. The use of such system for facilitating locomotor functions or upper limb movements in a subject with neuromotor impairments is also within the scope of the invention.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A63B 22/02 - Exercising apparatus specially adapted for conditioning the cardio-vascular system, for training agility or co-ordination of movements with movable endless bands

Abstract

An electrostatic actuator for translational motion between a stator and a slider in a longitudinal direction (X), comprising a stator driving electrodes and slider driving electrodes arranged with a respective pitch along said direction (X), wherein said actuator is driven by n power supply outputs and the stator and/or slider driving electrodes are interconnected into n stator and/or slider power busses, characterised in that said slider and stator busses are such that the connection of the n stator busses is configured in a predetermined order, while the connection of the n slider busses are configured in a different predetermined order, each of said n power supply outputs are configurable to provide different phases of time-varying power allowing to create a first and a second potential distribution travelling over the pitch of the stator or slider driving electrodes, in the opposite direction to each other.

IPC Classes  ?

• H02N 1/00 - Electrostatic generators or motors using a solid moving electrostatic charge carrier

Abstract

The present invention concerns a structure (10) of architectured material for a mechatronic manipulator (1) and a mechatronic manipulator having one or more degrees of freedom by using such structure which comprises at least one hollow flexible unit (11) comprising at least one elastic deformable material, characterized in that said hollow flexible unit (11) comprises at least two first helicoids (H1) having a generatrix and a first twist direction and at least two second helicoids (H2) having a generatrix and a second twist direction opposite to the first twist direction, resulting in said first and second helicoids being intertwined, said intertwined helicoids being trimmed around their centers along a direction parallel to said generatrixes so as to form said hollow flexible unit (11) of trimmed helicoids.

IPC Classes  ?

• B25J 9/06 - Programme-controlled manipulators characterised by multi-articulated arms
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 18/02 - Arms extensible
• B25J 18/06 - Arms flexible

Abstract

The present invention relates to a system (100), especially a closed-loop system, for planning and/or providing neurostimulation/neuromodulation for enabling a body function, especially a motor function and/or autonomic function, and/or treatment of a body condition of a mammal, especially a human patient (P).

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/372 - Arrangements in connection with the implantation of stimulators
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

The invention relates to a gate unit (22) for controlling a gate commutated thyristor (21), comprising: —a voltage selector (26) for selectively applying a high supply potential (Vpos), a middle supply potential (Vmid), and a low supply potential (Vneg); —a nonlinear inductor (27) serially coupled between the output of the voltage selector (26); —a gate control unit (23) configured to control the voltage selector (26) to control switching of the gate commutated thyristor (21) in its turn-on state comprising a turn-on pulse generation, a positive-gate-voltage backporch operation, a negative-gate-voltage backporch operation and a retrigger pulse generation; wherein the nonlinear inductor (27) has a nonlinearity to have a high inductance during any of the backporch operations and to have a low inductance during the turn-on pulse generation and retrigger pulse generation.

IPC Classes  ?

• H03K 17/13 - Modifications for switching at zero crossing
• H02M 1/00 - Details of apparatus for conversion
• H02M 1/08 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters
• H02M 3/00 - Conversion of DC power input into DC power output
• H02M 3/315 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only

Abstract

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for dimensionality reduction of time-series using contrastive learning. A method can include receiving multidimensional input time series data that includes data from a session or sessions that span time, selecting positive samples and negative samples from the multidimensional input time series data for respective reference samples from the multidimensional input time series data, wherein the positive samples and negative samples are each selected with a respective predetermined distribution across the time of the session or sessions of the multidimensional input time series, and mapping the reference samples, the positive samples, and negative samples into a common embedding space.

IPC Classes  ?

• G06F 16/28 - Databases characterised by their database models, e.g. relational or object models
• G06F 16/22 - IndexingData structures thereforStorage structures

Abstract

A method and a setup for light detection and ranging are disclosed. The setup is configured to carry out the following method: generating signal radiation at multiple signal frequencies with an optical signal source, wherein the signal radiation exhibits random signal modulations preferably at each of the multiple signal frequencies, splitting the signal radiation into a target radiation part and a reference radiation part, directing the target radiation part towards a target, detecting a target signal, wherein the target signal is associated with a reflected portion of the target radiation part being reflected from the target, detecting a reference signal, wherein the reference signal is associated with the reference radiation part, and deriving at least one ranging information parameter from the target signal and the reference signal.

IPC Classes  ?

• G01S 7/4913 - Circuits for detection, sampling, integration or read-out
• G01S 7/481 - Constructional features, e.g. arrangements of optical elements
• G01S 7/4915 - Time delay measurement, e.g. operational details for pixel componentsPhase measurement
• G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging

Abstract

A force-feedback surface that creates and modulates distinctive profile and stiffness to interact with a user in contact thereto, the surface being functionally independent to be used as a single module but can be customized to extend the application in diverse fields by assembling in series, parallel, or any combinations to form a multimodular system.

IPC Classes  ?

• B25J 9/00 - Programme-controlled manipulators
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 9/16 - Programme controls

Abstract

12012020-hydrocarbyl alcohol, a base, and a catalyst in the presence of carbon dioxide and a reducing agent to a temperature of 20 to 250°C, wherein the catalyst comprises a metal of group VIIIB of the periodic table on an inorganic carrier, and wherein the carbon dioxide is present in gaseous form at a pressure of 5 to 100 bar. Also described is a method for preparing a catalyst comprising a metal of group VIIIB of the periodic table on a carrier, the method comprising a. preparing a solution of a salt of a metal of group VIIIB of the periodic table in a solvent, b. adding a reducing agent to the solution to obtain a treated solution, c. adding a carrier to the treated solution, d. removing the solvent to obtain a wet catalyst, and e. heating the wet catalyst to obtain the catalyst.

IPC Classes  ?

• B01J 29/12 - Noble metals
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/16 - Reducing
• C07C 67/00 - Preparation of carboxylic acid esters
• C07C 69/003 - Esters of saturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
• C07C 69/00 - Esters of carboxylic acidsEsters of carbonic or haloformic acids

Abstract

Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61K 9/107 - Emulsions
• A61K 9/51 - Nanocapsules
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 14/62 - Insulins
• C07K 14/74 - Major histocompatibility complex [MHC]
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 9/82 - Asparaginase

Abstract

The present invention concerns a method for producing at least one ferroelectric device or structure comprising the steps of providing at least one ferroelectric material or layer, or providing at least one ferroelectric material or layer to be patterned or structured; depositing at least one adhesion layer on a first side of the at least one ferroelectric material or layer; and depositing at least one diamond-like carbon layer or material on the at least one adhesion layer.

IPC Classes  ?

• G02B 6/136 - Integrated optical circuits characterised by the manufacturing method by etching
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02F 1/00 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

An apparatus for observing dynamic systems by time-resolved microscopy has an optical microscope including a cryo stage for receiving a cryo sample and maintaining the cryo sample at a cryogenic temperature, a heating system configured to temporarily heat at least a portion of the cryo sample such that the portion of the cryo sample melts to a liquid state, temporarily resides in the liquid state, and then revitrifies, and an image detector associated with the optical microscope for detecting magnified images of the cryo sample generated by the optical microscope. Detected images may be recorded and analyzed to inform on-the-fly adjustment of heating power level delivered to the cryo sample. In a correlative light-electron microscopy method, the revitrified cryo sample is observed using an electron microscope.

IPC Classes  ?

• G02B 21/30 - Base structure with heating device
• G02B 21/06 - Means for illuminating specimen
• G02B 21/26 - StagesAdjusting means therefor
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• H01J 37/22 - Optical or photographic arrangements associated with the tube
• H01J 37/26 - Electron or ion microscopesElectron- or ion-diffraction tubes

Abstract

Electronic metadevice comprising a conductive channel; a metal layer superposed on the conductive channel; and a barrier layer located between the metal layer and the conductive channel. The metal layer includes at least one recess extending through the metal layer to define at least one metallic metastructure comprising at least one first metal layer portion adjacent to at least one second metal layer portion. The recess extends through the metal layer to define a micro-structured or a nano-structured first metal layer portion comprising at least one first metallic extension or finger extending away from a first support of the first metal layer portion towards the second metal layer portion; and a micro-structured or a nano-structured at least one second metal layer portion comprising at least one second metallic extension or finger extending away from a second support of the second metal layer portion towards the first metal layer portion.

IPC Classes  ?

• H01L 29/41 - Electrodes characterised by their shape, relative sizes or dispositions
• H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
• H01L 29/417 - Electrodes characterised by their shape, relative sizes or dispositions carrying the current to be rectified, amplified or switched
• H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
• H01L 29/86 - Types of semiconductor device controllable only by variation of the electric current supplied, or only the electric potential applied, to one or more of the electrodes carrying the current to be rectified, amplified, oscillated, or switched

Abstract

The present disclosure relates to a microfluidic device comprising: a substrate; a culture chamber (130); a loading channel (170) in fluid communication with the culture chamber; at least one auxiliar channel (170-1, 5 170-2) extending from and in fluid communication with the loading channel, wherein the at least one auxiliary channel is so dimensioned such that a hydraulic resistance in the at least one auxiliary channel is higher than a hydraulic resistance in the loading channel; a test area (150) defined along the loading channel at a position between the loading channel and the at least one auxiliary channel; a first medium reservoir (110) in fluid communication with a first side of the test area; and a second medium reservoir (120) in fluid communication with a second side of the test area, the second side being different from the first side.

IPC Classes  ?

• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

ffWfWW ⋆WfWWW ⋆WWW ⋆WWW ⋆W Wff.

IPC Classes  ?

• H03M 13/00 - Coding, decoding or code conversion, for error detection or error correctionCoding theory basic assumptionsCoding boundsError probability evaluation methodsChannel modelsSimulation or testing of codes
• H03M 13/13 - Linear codes
• H03M 13/45 - Soft decoding, i.e. using symbol reliability information
• H04L 1/00 - Arrangements for detecting or preventing errors in the information received

Abstract

1. The present invention relates to a method for preparing a catalyst comprising the steps of a. dissolving two or more alloy metal salts, b. adding at least one chelating agent and at least one stabilising agent, forming a sol, c. adding an encapsulant to said sol, d. evaporating said sol, forming a gel, e. drying said gel in the presence of oxygen, forming a powder, f. reducing said powder, forming a catalyst. The invention further relates to a catalyst, characterised in that the catalyst is stable for at least 200 h at a current density of 1.0 A/cm2. The invention further relates to catalyst comprising two or more metal alloys, wherein the two or more metal alloys are encapsulated by a metal oxide.

IPC Classes  ?

• B22F 1/16 - Metallic particles coated with a non-metal
• B01J 23/00 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group
• B01J 23/83 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with rare earths or actinides
• B01J 37/03 - PrecipitationCo-precipitation
• B01J 37/18 - Reducing with gases containing free hydrogen
• B22F 9/26 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions using gaseous reductors
• C22C 1/04 - Making non-ferrous alloys by powder metallurgy
• C22C 33/02 - Making ferrous alloys by powder metallurgy
• C25B 3/26 - Reduction of carbon dioxide
• C25B 11/069 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of at least one single element and at least one compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of two or more compounds
• C25B 11/089 - Alloys
• C25B 1/23 - Carbon monoxide or syngas
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 11/071 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of at least one single element and at least one compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the substrate or carrier material consisting of two or more compounds comprising metal or alloy powder and non-metallic binders
• C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide
• B01J 35/33 - Electric or magnetic properties

Abstract

121414323232453678234514614789143031303110213214111213131414 are independently selected from a hydrocarbon moiety with 1 to 10 carbon atoms; and n and p are independently from each other either 0 or 1.

IPC Classes  ?

• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 9/04 - Cyclic acetals

Abstract

One aspect of the present invention proposes a method of predicting meteorological information by using an artificial deep neural network. The present invention according to one example focuses on image processing, specifically on fusing a plurality of images obtained by different webcams. It introduces a novel neural network architecture that combines a convolutional neural network (CNN) and long short-term memory (LSTM). The purpose of this fusion is to enhance the accuracy of predicting meteorological information compared to using a single image. By leveraging the capabilities of CNN and LSTM, the invention aims to improve the fusion process by extracting significant features from the images (such as clouds and shades) while considering the temporal aspect of the data.

IPC Classes  ?

• G01W 1/10 - Devices for predicting weather conditions
• G06N 3/0442 - Recurrent networks, e.g. Hopfield networks characterised by memory or gating, e.g. long short-term memory [LSTM] or gated recurrent units [GRU]
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06N 3/08 - Learning methods
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 20/70 - Labelling scene content, e.g. deriving syntactic or semantic representations

Abstract

A photonic assembly, a laser setup having the photonic assembly and a method for performing frequency-modulated continuous-wave light detection and ranging using the laser setup are disclosed. The photonic assembly has an active photonic chip, a photonic modulator chip, and a tuning arrangement having a modulation element having a thickness of 10 micrometers or less. The active photonic chip and the photonic modulator chip are optically coupled such, that injection radiation at an optical feedback wavelength is generated, which defines at least one optical lasing wavelength at which the optical radiation is emitted by the active photonic chip. The modulation element is arranged such, that an actuation of the modulation element tunes the optical feedback wavelength via the Pockels effect, such, that a tuning of the optical feedback wavelength entails a tuning of the optical lasing wavelength.

IPC Classes  ?

• G01S 7/4911 - Transmitters
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure

Abstract

A method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject includes: (a) determining the protein level of at least one protein in the sample of isolated cholesterol-rich lipoprotein nanoparticles; and (b) comparing the determined protein level to the corresponding protein level in one or more samples of cholesterol-rich lipoprotein nanoparticles obtained from one or more healthy subjects or a predetermined standard obtained from a corresponding protein level in one or more samples of cholesterol-rich lipoprotein nanoparticles obtained from one or more healthy subjects. An at least 1.5-fold increase or decrease of the determined protein level as determined in (a) as compared to the protein level in one or more samples of cholesterol-rich lipoprotein nanoparticles obtained from one or more healthy subjects or the predetermined standard indicates that the test subject has cancer.

IPC Classes  ?

• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention concerns a single-particle inductively-coupled plasma (ICP) mass spectrometry particle sizing and counting method comprising providing or receiving an intensity-versus-counts histogram of particles detected using an ICP mass spectrometer, the intensity representing particle detection and the count representing particle detection frequency; providing or receiving mass flux calibration data or calibration curve data relating a value of the intensity measurement or data of the ICP mass spectrometer to a mass of material detected per acquisition interval or dwell time; determining a particle mass of the particles detected using the mass flux calibration data or the at least one mass flux calibration curve data, determining a particle volume of the detected particles using the determined particle mass, and determining a particle size of the particles detected using the determined particle volume of the particles detected and a determined or attributed geometry or shape of the detected particles.

IPC Classes  ?

• G01N 15/10 - Investigating individual particles
• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 49/10 - Ion sourcesIon guns

Abstract

Disclosed herein is a method of operating a microfluidic system, a microfluidic system for manipulating sample objects, and a control system for operating a microfluidic system. The method according to the invention is for operating a microfluidic system that comprises a manipulation zone for manipulating sample objects flowing through the manipulation zone, a first detection zone arranged upstream of or in the manipulation zone and a second detection zone arranged upstream of, in or downstream of the manipulation zone. A first count is determined that characterizes a number of sample objects flowing through the first detection zone. Sample objects are manipulated in the manipulation zone. A second count is determined that characterizes a number of sample objects flowing through the second detection zone. One or more manipulation parameters for manipulating the sample objects in the manipulation zone are adjusted based on the first count and the second count.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The disclosure concerns a steerable device for use as e.g. a guidewire for insertion into a subject's body. The device features a single side deflection of a bendable portion located at its distal end by application of a longitudinally-directed force either on an inner pull wire or on the bendable portion. The bendable portion is characterized by the presence of a reinforcement structure on one lateral side and a stress relief portion on the opposed lateral side that, upon actuation of the device, allows single side bending thanks to the physical constriction of the reinforcement structure, limiting the compression of one side of the bendable portion. The disclosure further concerns a system further comprising the steerable device and an actuator, as well as methods for using thereof.

IPC Classes  ?

• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 25/09 - Guide wires

Abstract

The invention provides fusion protein comprising a SCAN domain bearing member of a zinc finger-containing protein, a fragment or variant thereof and a catalytically inactive RNA- guided endonuclease or a DNA adenine methyltransferase. Preferably, the fusion protein is for use in the treatment and/or prevention of cancer, neurodegenerative disease, neurodevelopmental disease, aging and aging-related disease.

IPC Classes  ?

• C12N 15/62 - DNA sequences coding for fusion proteins
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 9/10 - Transferases (2.)
• C12N 9/22 - Ribonucleases

Abstract

The invention relates to use of an aerolysin nanopore for the discrimination of different protein isoforms bearing different post-translational modifications (PTMs) and to methods for detecting adverse medical conditions associated with the presence of peptides, polypeptides or proteins bearing particular PTMs.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

The present invention relates generally to the field of anti-cancer therapy, in particular to the use of adoptive T cell transfer therapy for treating cancer, in particular sold tumors. More specifically, the present invention relates to immune cells comprising one or more recombinant constructs, wherein at least one recombinant construct encodes an interleukin-10, a fragment or a variant thereof.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 38/20 - Interleukins
• A61P 35/00 - Antineoplastic agents
• C07K 14/725 - T-cell receptors
• C07K 16/22 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes

Abstract

The invention relates to a microfluidic device (3) comprising: —an inlet channel (31) having an inlet configured to be operatively connected with a droplet source (2) wherein the inlet channel (31) has a width wi and height hi; and —an outlet channel with at least one outlet channel branch (32) operatively connected with the inlet channel (31) at a passage point (33), said outlet channel (32) having a width wo, wherein the width wo of the at least one outlet channel branch (32) and the height hi and the width wi of the inlet channel (31) satisfy a geometrical condition of formula (I), said z>1.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A terahertz device for detecting or emitting or for both detecting and emitting electromagnetic waves in the terahertz frequency range. The terahertz device comprises: a first waveguide branch and a second waveguide branch, the first and second waveguide branches being configured to allow optical signals to propagate through them, the first and second waveguide branches being nonlinear dielectric elements with a thickness of at most 500 micrometres; and an antenna arrangement comprising a set of antennas for capturing and/or emitting electromagnetic waves in the terahertz frequency range, the antennas being placed along at least one of the waveguide branches in an immediate vicinity of the respective waveguide branch and/or around the respective waveguide branch to at least partially enclose the respective waveguide branch in a respective antenna gap of the respective antenna.

IPC Classes  ?

• H01Q 21/28 - Combinations of substantially independent non-interacting antenna units or systems
• H01L 23/66 - High-frequency adaptations
• H01Q 1/22 - SupportsMounting means by structural association with other equipment or articles

Abstract

A device (1) and method for processing data comprises at least one input layer (2), at least one modulation layer (3), and at least one output layer (4). The input layer (2) is configured to receive at least one carrier signal (Sc). The modulation layer (3) comprises input data. The modulation layer (3) is configured to modulate the carrier signal (Sc) such, that a modulated carrier signal (Smc) comprising the input data being linearly transformed is generated. The device (1) is configured such, that the modulated carrier signal (Smc) is repeatedly modulated with the input data and linearly transformed, wherein an output signal (So) comprising output data is produced at the output layer (4), and wherein the output data comprises or consists of the input data being nonlinearly processed.

IPC Classes  ?

• G02F 1/365 - Non-linear optics in an optical waveguide structure
• H04B 10/50 - Transmitters
• H04B 10/516 - Details of coding or modulation

Abstract

The present invention relates to a variant of cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution at one or more of (i) asparagine at amino acid position 513, (ii) asparagine at amino acid position 514, (iii) aspartic acid at amino acid position 465, (iv) glutamic acid at amino acid position 509, (v) tyrosine at amino acid position 510, (vi) arginine at amino acid position 512, (vii) lysine at amino acid position 427, and (viii) lysine at amino acid position 428. The present invention also relates to a variant of SplA/Ryanodine Receptor Domain And SOCS Box Containing 3 (SPSB3) carrying an amino acid substitution at one or more of (i) arginine at amino acid position 213, (ii) tyrosine at amino acid position 197, (iii) threonine at amino acid position 162, (iv) threonine at amino acid position 259, (v) arginine at amino acid position 262, (vi) serine at amino acid position 132, (vii) tyrosine at amino acid position 131, and (viii) tyrosine at amino acid position 160.

IPC Classes  ?

• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• A61K 38/00 - Medicinal preparations containing peptides
• C12P 19/30 - Nucleotides

Abstract

The invention relates to a dopant-free perovskite optoelectronic or photovoltaic device presenting molecular orbital stretching-junction, wherein the hole transport layer is a multilayer structure comprising at least two layers, each layer comprising a different hole transport material (HTM) having a different ionization energy (IP) for each layer and selected from donor material or acceptor material. The sequence of the layers in the multilayer structure of the hole transport layer is configured such that the layer of the hole transport layer in direct contact with the light-harvesting layer (4) is a layer comprising a donor material with an IP value being ≤-5.00 eV and ≥-5,60 eV, which is equal to or higher than the IP value of the organic/inorganic metal halide perovskite, the IP value of each HTM being lower than the work function of a material of the back contact or the counter electrode.

IPC Classes  ?

• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
• H10K 30/80 - Constructional details
• H10K 85/10 - Organic polymers or oligomers
• H10K 85/60 - Organic compounds having low molecular weight
• C07D 471/16 - Peri-condensed systems

Abstract

The present invention concerns a system for phenotypical profiling of at least one object and deterministic nanoliter-droplet encapsulation, comprising sample supplying means, buffer supplying means; a microfluidic chip comprising an encapsulation area or structure in which the object is encapsulated with a quantity of the reaction buffer by the droplet; detection means configured to detect the passage of the object through the first imaging chamber; at least one valve configured to stop the flow of the sample buffer when the detection means detect passage of the object through the first imaging chamber; phenotypical assessing means configured to assess the phenotype of the object when the flow of the sample buffer is stopped by the valve and the object is at an object stopping site; a droplet deposition means configured to deposit the droplet in a well or in a well of a multi-well plate and comprising an outlet capillary.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means

Abstract

outoutLL) connected between said output node (10) and ground.

IPC Classes  ?

• H03K 4/02 - Generating pulses having essentially a finite slope or stepped portions having stepped portions, e.g. staircase waveform
• H02M 3/07 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using resistors or capacitors, e.g. potential divider using capacitors charged and discharged alternately by semiconductor devices with control electrode
• H03K 3/03 - Astable circuits

Abstract

A near-infrared sensitivity enhanced substrate non-isolated silicon single-photon avalanche diode is disclosed, comprising a p-well layer (101), a high-voltage n-well (102), the p-well layer and the high- voltage n-well layer positioned against each other and configured to form a main junction (100) defining an active area (104), the p- well layer comprising a doping according to a doping concentration distribution, the p-well layer being configured to have first double peaks in its doping concentration distribution throughout the p-well layer in the active area, corresponding to respective p-doped regions, and the high-voltage n-well being configured to have second double peaks, corresponding to respective n-doped regions configured to achieve a n-p-n-p type device junction profile, whereby further the p- well layer is lightly doped and configured to obtain a wide depletion region, i.e., at least 1 μm wide, the high-voltage n-well layer being further configured to extend beyond the p-well layer to form a guard ring (103) around the active area.

IPC Classes  ?

• H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode

Abstract

The present invention relates generally to the field of nucleic acid sequencing and provides oligonucleotide molecules and barcodes contained therein. These oligonucleotide molecules and barcodes molecules are useful in sequencing to identify and resolve errors.

IPC Classes  ?

• C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

Herein described is a two-component paint comprising a first component containing a first solvent and polymer particles comprising particle functional groups that are negatively or positively charged and a second component containing a second solvent and an agent with antimicrobial activity that has an agent functional group with a charge opposite to the charge of the particle functional groups. Further described is a method for the preparation of an antimicrobial surface by applying the first component as a base coat and the second component to the base-coated surface. Also described is the use of the two-component paint for preparing an antimicrobial surface. Further described is an antimicrobial surface comprising a base coat and an active coat.

IPC Classes  ?

• C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides
• C09D 7/80 - Processes for incorporating ingredients
• C09D 133/00 - Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereofCoating compositions based on derivatives of such polymers

Abstract

222O co-electrolyser system further comprises a mineralization system (3) including a mineralization unit (27) connected to the anolyte circuit (18) and containing a mineralization metal configured to react with the carbonate and bicarbonate ions circulating in the anolyte circuit (18) to form a metal carbonate.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• C07C 1/04 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of carbon from carbon monoxide with hydrogen
• C10L 3/08 - Production of synthetic natural gas
• C25B 1/23 - Carbon monoxide or syngas
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes
• C01B 32/60 - Preparation of carbonates or bicarbonates in general
• C01F 5/24 - Magnesium carbonates
• C25B 1/01 - Products
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials

Abstract

The invention provides pharmaceutical compositions, combinations and vectors, such as expression vectors, as well as use thereof in a method for central nervous system repair after neurotrauma, such as spinal cord injury (SCI) or stroke and in a method for regenerating spinal cord or brain neurons within a subject having a spinal cord injury (SCI), stroke or other neurotraumatic conditions.

IPC Classes  ?

• A61K 38/18 - Growth factorsGrowth regulators
• A61K 38/30 - Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
• A61P 25/00 - Drugs for disorders of the nervous system
• C12N 15/86 - Viral vectors

Abstract

Silicon nitride waveguide fabrication method including providing a substrate including a stress release trench structure, the stress release recess structure being formed in a silicon oxide layer, depositing a silicon nitride material or layer onto the silicon oxide layer, providing a silicon oxide hard mask on the deposited silicon nitride material or layer to provide an exposed surface delimited by the silicon oxide hard mask and defined by the deposited silicon nitride material or layer, the silicon oxide hard mask including or defining an elongation extending on the deposited silicon nitride material or layer, dry etching the exposed surface a silicon nitride elongated waveguide core located between the silicon oxide hard mask and the silicon oxide layer in which the stress release trench structure is formed; and depositing a silicon oxide cladding layer on the silicon oxide hard mask to form a cladding structure of the silicon nitride waveguide.

IPC Classes  ?

• G02B 6/132 - Integrated optical circuits characterised by the manufacturing method by deposition of thin films
• G02B 6/136 - Integrated optical circuits characterised by the manufacturing method by etching
• G02B 6/122 - Basic optical elements, e.g. light-guiding paths
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind

Abstract

The present invention relates to method for the synthesis of a transition metal catalyst consisting of electrodeposition on a substrate electrode from an electrolyte solution comprising at least one transition metal precursor, wherein the electrodeposition takes places at a deposition current density of 500 to 2000 mA/cm2characterised in thatcharacterised in that it is stable for at least 30 minutes at a current density of at least 400 mA/cm2 on the substrate electrode.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/061 - Metal or alloy
• C25B 11/063 - Valve metal, e.g. titanium
• C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• C25D 13/02 - Electrophoretic coating characterised by the process with inorganic material
• H01M 8/08 - Fuel cells with aqueous electrolytes

Abstract

The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron to an other spatially-extended neuron along the arborized projection, defining a second temporal filter for the conveyance of input from yet another neuron to the spatially-extended neuron along the arborized projection, replacing, in the neural network model, the first, spatially-extended neuron with a first, spatially-constrained neuron and the arborized projection with a first connection extending between the first, spatially-constrained neuron and the second neuron, wherein the first connection filters input from the second neuron in accordance with the first temporal filter and a second connection extending between the first spatially-constrained neuron and the third neuron.

IPC Classes  ?

• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs
• G06N 3/08 - Learning methods
• G06N 3/082 - Learning methods modifying the architecture, e.g. adding, deleting or silencing nodes or connections

Abstract

The present invention relates to an integrated imaging system. The integrated imaging system includes an array of analog photomultiplier elements. The integrated imaging system includes a plurality of submodules, each submodule having a number of the photomultiplier elements. The integrated imaging system includes a plurality of time-to-digital converters each associated and coupled with one of the submodules. The plurality of time-to-digital converters are configured to provide a respective timing information.

IPC Classes  ?

• G01T 1/24 - Measuring radiation intensity with semiconductor detectors

Abstract

The present invention relates to a system (1) for combined transcranial focused ultrasound and magnetic resonance imaging, comprising: a plurality of dielectric resonator antennas (2), each dielectric resonator antenna (2) comprising a dielectric medium (20) and configured to be arranged on an animal or human head (3), a plurality of RF feed assemblies (4), each RF feed assembly arranged in proximity to an associated dielectric resonator antenna (2) of said plurality of dielectric resonator antennas and configured to provide an electromagnetic field to excite its associated dielectric resonator antenna (2) to transmit an RF signal into the head for MRI, and a plurality of ultrasound transducers (5), each ultrasound transducer (5) being arranged on an associated dielectric resonator antenna (2) of said plurality of dielectric resonator antennas and configured to transmit ultrasound signals into the head (3), and wherein the respective ultrasound transducer (5) is configured to couple the respective ultrasound signal into the head (3) via the dielectric medium (20) of its associated dielectric resonator antenna (2).

IPC Classes  ?

• G01R 33/48 - NMR imaging systems
• G01R 33/3415 - Constructional details, e.g. resonators comprising surface coils comprising arrays of sub-coils
• A61N 7/02 - Localised ultrasound hyperthermia

Abstract

Photonic integrated circuit optical waveguide device preparation or fabrication method comprising providing a silicon substrate, depositing at least one copper gettering silicon nitride layer or material, depositing at least one optical waveguide cladding layer or material, forming at least one optical waveguide or optical waveguide structure and thermally annealing the at least one silicon substrate after the formation of the at least one optical waveguide or optical waveguide structure on the at least one silicon substrate to remove hydrogen impurities or hydrogen-related impurities from the at least one optical waveguide, and to capture or trap copper impurities of the at least one silicon substrate in the at least one copper gettering silicon nitride layer or material.

IPC Classes  ?

• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 21/322 - Treatment of semiconductor bodies using processes or apparatus not provided for in groups to modify their internal properties, e.g. to produce internal imperfections
• H01L 21/324 - Thermal treatment for modifying the properties of semiconductor bodies, e.g. annealing, sintering
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind

Abstract

A method of forming a structure, preferably a pore, comprises the steps of providing a template comprising at least one template aperture, and growing at least one material at an orifice of the template aperture by depositing the material, whereby the structure is formed.

IPC Classes  ?

• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 71/02 - Inorganic material
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• F03G 7/00 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for
• G01N 33/487 - Physical analysis of biological material of liquid biological material
• H01M 8/22 - Fuel cells in which the fuel is based on materials comprising carbon or oxygen or hydrogen and other elementsFuel cells in which the fuel is based on materials comprising only elements other than carbon, oxygen or hydrogen

Abstract

The invention relates to TDP-43 protein mutants and uses thereof. The invention further relates to methods for the preparation of TDP-43 protein mutants aggregates, including fibrils and uses thereof. The invention further relates to use the TDP-43 protein mutants for the identification and screening of modulators of TDP-43 protein aggregation and related methods.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Herein described is a method for chlorination of a substrate compound containing an aromatic moiety, in particular an arene moiety with 3 to 20 carbon atoms, wherein the substrate compound is reacted with a chlorine-donor, in particular an organic chlorine donor, in the presence of a catalyst, an oxidising agent, and a solvent. Also described is the use of a chlorine-containing compound, in particular a chlorine-containing solid or liquid organic compound, more particularly a chlorinated organic waste compound, as chlorine-donor for the chlorination of a substrate compound containing an aromatic moiety, in particular an arene moiety, with 3 to 20 carbon atoms.

IPC Classes  ?

• C07D 213/26 - Radicals substituted by halogen atoms or nitro radicals
• C07C 17/12 - Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
• C07D 215/12 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
• C07D 215/40 - Nitrogen atoms attached in position 8
• C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 231/56 - BenzopyrazolesHydrogenated benzopyrazoles
• C07D 239/26 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 239/74 - QuinazolinesHydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
• C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to a neuromodulation/neurostimulation system (100) for restoring a motor function of the upper and/or lower limbs and facilitating neurological recovery in a patient (P) with spinal cord injury (SCI) and/or other neurological disorders, said system (100) comprising: a processing unit (10), which is configured and adapted provide stimulation commands; an implantable or external stimulation unit (12), which is configured and adapted to deliver neuromodulation therapy, in particular epidural electrical stimulation (EES) to the dorsal roots of the spinal cord (SC) of said patient (P); at least one implantable or external pulse generator (14), operatively connected to the stimulation unit (12); an implantable neurosensor (16) including electronic components that are configured and adapted to detect electrocorticographic (ECoG) signals from the sensorimotor cortex (C) of said patient (P), denoting a motor intention of said patient (P), wherein the processing unit (10), the stimulation unit (12) and the implantable neurosensor (16) are operatively connected to define a brain-spinal interface (BSI), and wherein the processing unit (10) is configured and adapted to: collect and decode, preferably in real-time, the ECoG signals from the sensorimotor cortex (C) into a corresponding motor intention of said patient (P); converting, preferably in real-time, the decoded motor intentions into corresponding stimulation commands, and forwarding, preferably in real-time, the stimulation command to the at least one pulse generator (14).

IPC Classes  ?

• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61F 4/00 - Methods or devices enabling patients or disabled persons to operate an apparatus or a device not forming part of the body
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• G06F 3/00 - Input arrangements for transferring data to be processed into a form capable of being handled by the computerOutput arrangements for transferring data from processing unit to output unit, e.g. interface arrangements

Abstract

Small molecules have been the preferred modality for drug development and therapeutic interventions. This molecular format presents a number of advantages, e.g. long half-lives and cell permeability, making it possible to access a wide range of therapeutic targets. However, finding small molecules that engage “hard-to-drug” protein targets specifically and potently remains an arduous process, requiring experimental screening of extensive compound libraries to identify candidate leads. The search continues with further optimization of compound leads to meet the required potency and toxicity thresholds for clinical applications. Here, we propose a new computational workflow for high-throughput fragment-based screening and binding affinity prediction where we leverage the available protein-ligand complex structures using a state-of-the-art protein surface embedding framework (dMaSIF). We developed a tool capable of finding suitable ligands and fragments for a given protein pocket solely based on protein surface descriptors, that capture chemical and geometric features of the target pocket. The identified fragments can be further combined into novel ligands. Using the structural data, our ligand discovery pipeline learns the signatures of interactions between surface patches and small pharmacophores. On a query target pocket, the algorithm matches known target pockets and returns either potential ligands or identifies multiple ligand fragments in the binding site. Our binding affinity predictor is capable of predicting the affinity of a given protein-ligand pair, requiring only limited information about the ligand pose. This enables screening without the costly step of first docking candidate molecules. Our framework will facilitate the design of ligands based on the target's surface information. It may significantly reduce the experimental screening load and ultimately reveal novel chemical compounds for targeting challenging proteins.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G16B 40/20 - Supervised data analysis

Abstract

The present invention relates to one or more antibiotic(s) that disrupt(s) the microbial balance of the gut and a microorganism having bile acid 7α-dehydroxylation activity for use in the treatment of a non-infectious disease in a subject.

IPC Classes  ?

• A61K 35/74 - Bacteria
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61K 38/14 - Peptides containing saccharide radicalsDerivatives thereof
• A61K 31/4164 - 1,3-Diazoles
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention relates to a neuromodulation/neurostimulation system for supporting and/or controlling a function of t he respiratory system of a patient, said function comprising a plurality of phases each involving one or more muscles. The system comprises: - at least one control unit, configured and/or adapted to provide stimulation data for each phase of said function of the respiratory system, and - at least one stimulation unit, operatively connected to the at least one control unit, wherein the at least one stimulation unit is configured and/or adapted to deliver electrical stimulation at least partially targeted to the dorsal roots of the thoracic region of the spinal cord innervating the trunk muscles of said patient, wherein said stimulation data include at least one stimulation parameter defined for each phase of said function of the respiratory system, and wherein, during each phase of said function of the respiratory system, the at least one control unit is configured and/or adapted to control the at least one stimulation unit to deliver electrical stimulation according to the at least one stimulation parameter defined for the ongoing phase of said function.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

The present invention relates to a cathepsin inhibitor comprising or consisting of Formula (I) (X1)(X2)(X3)(X4)(Y)(X5)(X6)(X7) Formula (I) wherein (X1) is an amino acid selected from K, L, F and M; (X2) is an amino acid selected from L, A, D, E, F, G, H, I, K, M, N, S, W, Y, Q and R; (X3) is an amino acid selected from R, A and L; (X4) is an amino acid selected from M, I, K, V and Y; (X5) is an amino acid selected from P, A, I, L, V, W and Y; (X6) is an amino acid selected from K, A, E, F, G, I, L, M, N, Q, S, T, V, W, Y and Q; (X7) is an amino acid selected from D, A, E, F, G, I, L, M, N, P, T, V, W, Y, Q and R; and (Y) is a Michael acceptor.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

Abstract

An optical reflector chip (10) comprising a waveguide arrangement (11) configured to guide optical radiation and a modulation device (3). The waveguide arrangement (11) comprises a Bragg grating section (111), the Bragg grating section (111) comprising a periodic structure exhibiting a periodically varying refractive index to reflect the optical radiation within a wavelength reflection band defined by the periodic structure. The modulation device (3) comprises a modulation element (30, 30'), at least a first electrode (31) and a second electrode (31), wherein the first electrode (31) and the second electrode (32) are configured to actuate the modulation element (30, 30') upon the application of a voltage between the first electrode (31) and second electrode (32). The modulation element (30, 30') is arranged such that actuating the modulation element (30, 30') by applying the voltage between the first electrode (31) and the second electrode (32) tunes the periodic structure of the Bragg grating section (111), whereby a shift of the wavelength reflection band is induced.

IPC Classes  ?

• H01S 5/06 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium
• H01S 5/14 - External cavity lasers
• H01S 3/107 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling devices placed within the cavity using electro-optic devices, e.g. exhibiting Pockels or Kerr effect
• G02B 5/18 - Diffracting gratings
• G02B 26/00 - Optical devices or arrangements for the control of light using movable or deformable optical elements
• G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure
• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour

Abstract

The present invention relates generally to the field of long non-coding RNAs and transcription factors and modulation of their expression for use in medicine and agriculture, such as the treatment and prevention of diseases associated with muscle atrophy and the production of livestock. More particularly, the invention provides agonists of Cytor, a long non-coding RNA, e.g. agents that increase the amount of Cytor RNA in skeletal muscle as well as antagonists for Teadl, a transcription factor, e.g. agents that decrease the amount of Teadl RNA or protein in skeletal muscle and their use in therapy.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A01K 67/0275 - Genetically modified vertebrates, e.g. transgenic
• A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

The present invention concerns an optical waveguide device (1) fabrication method comprising providing at least one optical waveguide or optical waveguide core (3); and depositing at least one silicon dioxide layer or material (15) onto the at least one optical waveguide or optical waveguide core (3) to form a cladding or passivation layer of the optical waveguide device (1). The at least one silicon dioxide layer or material (15) is deposited by plasma-enhanced chemical vapor deposition using precursors comprising or consisting of silicon tetrachloride and at least one oxidizer, the plasma being an inductively coupled plasma.

IPC Classes  ?

• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 6/132 - Integrated optical circuits characterised by the manufacturing method by deposition of thin films
• G02B 6/136 - Integrated optical circuits characterised by the manufacturing method by etching

Abstract

A conductive or semi-conductive cluster essentially comprises or consists of a first-type material, wherein the first-type material comprises a number of surface atoms that is at least half of a number of total atoms of the first-type material, and wherein the cluster comprises less than 100 ppm of a second-type material being different from the first-type material. The cluster is produced via spark ablation.

IPC Classes  ?

• B22F 9/14 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using physical processes using electric discharge
• B01J 23/38 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of noble metals
• B01J 23/70 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• H01M 4/90 - Selection of catalytic material
• B22F 1/054 - Nanosized particles
• B01J 23/42 - Platinum
• B01J 23/52 - Gold

Abstract

The present disclosure provides a method and a microfluidic device for producing one or more combinatorial microcompartment comprising at least two sample species within a carrier phase, the microfluidic device comprising a target channel, a first sample species reservoir comprising a first sample species and at least a second sample species reservoir comprising a second sample species, a first sample injection channel comprising a sample injection channel reservoir end connected to the first sample species reservoir and a sample injection channel junction end connected to the target channel, and at least a second sample injection channel comprising a sample injection channel reservoir end connected to the second sample species reservoir and a sample injection channel junction end connected to the target channel; wherein the sample injection channel junction end of the first sample injection channel and/or the second sample injection channel are valvelessly connected to the target channel and comprise at least one hydrodynamic resistor. The present disclosure also provides a method for co-localizing an entity with a barcode oligonucleotide or set of components thereof in a microfluidic device according to the invention.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

One aspect of the present invention relates to a method of fabricating a chemically active fibre device (1) by thermal drawing. The method comprises the steps of providing a preform, the preform comprising a support element (3) at least partially made of a first polymeric material; and carrying out a thermal drawing process of the preform to produce a thermally drawn fibre. The preform comprises one or more chemically active agents and/or biological materials configured to react with a fluid sample when the one or more chemically active agents and/or biological materials are in contact with the fluid sample. In this manner miniaturised lab-in-fibre devices can be fabricated.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• D01F 1/10 - Other agents for modifying properties
• D01F 8/00 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof

Abstract

Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device includes a housing shell defining a cavity between a first end and a second end of the housing shell, and an elastic membrane disposed within the cavity to divide the cavity into a fluidic channel that permits a flow of fluid from the first end to the second end and a sealed cavity. The elastic membrane deforms to change the volume of the sealed cavity responsive to pressure fluctuations between the first and second ends, thereby varying the fluidic resistance of the flow of fluid through the fluidic channel.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery

Abstract

The present invention relates to a method of treating or preventing a viral disease or viral infection comprising administering to a subject a compound of formula (I) or formula (II) The present invention relates to a method of treating or preventing a viral disease or viral infection comprising administering to a subject a compound of formula (I) or formula (II)

IPC Classes  ?

• A61K 31/65 - Tetracyclines
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

A computer-implemented method of training a neural network for generating upper or lower limb motion control signals to operate a virtual, robotic or prosthetic upper or lower limb, comprising providing or receiving, at a neural network, electromyographic data and associated kinematic upper or lower limb target data provided as a plurality of data chunks or blocks, and processing the plurality of data chunks or blocks to carrying out training of the neural network based on the plurality of data chunks or blocks; wherein each data chunk or block comprises a plurality of channel window data extracts and kinematic upper or lower limb target data associated with each channel window data extract; and optimizing the neural network architecture and hyperparameters using an optimization algorithm to provide a pretrained neural network for generating upper limb distal extremity motion control signals.

IPC Classes  ?

• A61F 2/54 - Artificial arms or hands or parts thereof
• A61F 2/58 - ElbowsWrists
• A61F 2/72 - Bioelectric control, e.g. myoelectric
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb