Abstract

A low-carbon production method and production system for cement clinker. The production method comprises calcining a metal oxide, which is obtained by converting carbonate in a raw material by means of a methane dry reforming reaction, to form cement clinker, and meanwhile obtaining synthesis gas. The production system uses a reformer furnace for methane dry reforming of carbonate to replace a carbonate decomposition furnace in an existing cement production system.

IPC Classes  ?

• C04B 7/42 - Active ingredients added before, or during, the burning process
• B01J 8/02 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds
• C01B 3/34 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents
• C01B 3/36 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using oxygen or mixtures containing oxygen as gasifying agents
• C04B 7/43 - Heat treatment, e.g. precalcining, burning, meltingCooling
• C04B 7/44 - BurningMelting
• C04B 7/47 - Cooling
• F27B 7/00 - Rotary-drum furnaces, i.e. horizontal or slightly inclined

Abstract

Provided are a design, preparation and application of a targeted activation enrichment type near-infrared probe and a photosensitizer. Specifically, provided are a novel molecular design, preparation and application method, so that, under the action of disease-related enzymes or chemical environments, fluorescence signals or photosensitive properties can be activated, and the probe or photosensitizer can effectively concentrate around disease-related cells and tissues. The compound is represented by formula I, and each variable is defined in the description.

IPC Classes  ?

• C07F 9/6558 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
• C07D 501/34 - Methylene radicals, substituted by oxygen atomsLactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
• A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
• A61K 31/546 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine containing further heterocyclic rings, e.g. cephalothin
• A61P 31/04 - Antibacterial agents
• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• G01N 21/64 - FluorescencePhosphorescence
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 49/00 - Preparations for testing in vivo

Abstract

Disclosed in the present invention is a genetically-engineered Yarrowia lipolytica strain highly producing carotenoids, which is obtained by constructing a xylose-induced activation system in the genetically-engineered Yarrowia lipolytica strain XK17 to control the induced expression of critical enzymes for synthesis of astaxanthin, wherein the critical enzymes for synthesis of astaxanthin comprise β-carotene hydroxylase CrtZ and β-carotene ketonase CrtW. Further disclosed in the present invention is the use of the genetically-engineered Yarrowia lipolytica strain in fermentation production of carotenoids. The present invention starts from the Yarrowia lipolytica strain XK17 highly producing β-carotene, and uses the xylose-induced activation system to separately control the expressions of the β-carotene hydroxylase (CrtZ) and β-carotene ketonase (CrtW) or only control the expression of the CrtW or the CrtZ, thereby separately achieving highly producing astaxanthin, or canthaxanthin, or zeaxanthin under the functions of a proper xylose induction concentration and induction opportunity.

IPC Classes  ?

• C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins
• C12P 23/00 - Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
• C12R 1/645 - Fungi

Abstract

A use of Hemerocallis citrina Baroni or an extract thereof as an active ingredient in preparing a composition for dispelling effects of an alcohol. In addition, the composition can also be used for auxiliary protection against alcoholic liver damage.

IPC Classes  ?

• A61K 36/896 - Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
• A61P 25/32 - Alcohol-abuse
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention provides a multi-objective optimization method and a device for catalytic cracking process, and a computer-readable storage medium. The multi-objective optimization method comprises following steps: determining a plurality of optimization objectives, a plurality of process decision variables corresponding to the plurality of optimization objectives, and a constraint range of each of the process decision variables; determining an objective function according to the plurality of optimization objectives and the plurality of process decision variables; adjusting a value of each of the process decision variables within the constraint range by SPEA2 algorithm, which improves filial generation evolution process through a path-based reproduction operator, thereby determining an operation data of the objective function on each of the process decision variables; determining an optimization objective value of each of the optimization objectives according to the operation data of each of the process decision variables; and determining the operation data as guide values of the plurality of process decision variables, corresponding to the plurality of optimization objectives, according to an optimal optimization objective value solution set.

IPC Classes  ?

• G05B 19/4155 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme

Abstract

An electrolytic cell and device for using a porous structure to regulate bubbles, and a method. The electrolytic cell (1) comprises a plurality of parallel electrolytic chambers, each electrolytic chamber comprising a cathode plate (11) and an anode plate (15) on two sides, wherein a separator (13) is provided between the cathode plate and the anode plate; a cathode electrode (12) and an anode electrode (14) are provided on two sides of the separator (13), respectively; and inner porous coalescing members (17) are mounted in the electrolytic chambers between the cathode plate (11) and the cathode electrode (12) and between the anode plate (15) and the anode electrode (14). By means of mounting the inner porous coalescing members (17) in the electrolytic chambers, the turbulence of a liquid is increased, the collision probability of micro-bubbles is improved, and coalescence sites are provided for the micro-bubbles, thereby inducing the coalescence and growth of the micro-bubbles. The problems of the increased voltage of the electrolytic chambers, the high electrolysis energy consumption and the difficulty in further increasing the current density, which are caused by micro-bubble clusters, can be effectively solved, and the foaming of two-phase flows in the chambers can be effectively prevented. Due to the reduction in the micro-bubbles, the efficiency of subsequent gas-liquid separation is greatly improved, and the volume of a gas-liquid separation device is effectively reduced.

IPC Classes  ?

• C25B 9/70 - Assemblies comprising two or more cells
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/21 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms two or more diaphragms
• C25B 9/60 - Constructional parts of cells

Abstract

The present invention relates to the technical field of organic matter separation and purification. Disclosed are a mixer and an acid-hydrocarbon separation system and method. The mixer comprises: a housing, wherein a mixing cavity is provided inside the housing, a first liquid inlet through which a raw material liquid enters the mixing cavity is provided on the head end of the housing, and a liquid mixture outlet through which a liquid mixture flows out of the mixing cavity is provided on the tail end of the housing; and a conveying pipe, the conveying pipe running through the mixing cavity via the head end of the housing and extending to the tail end of the housing, wherein a first port of the conveying pipe located at the head end extends out of the housing and forms a second liquid inlet, a second port of the conveying pipe located at the tail end is closed, the part of the conveying pipe located in the mixing cavity forms a spraying section, a plurality of spraying holes distributed at intervals and configured to spray to the mixing cavity a dispersed phase inputted through the second liquid inlet are provided in the pipe wall of the spraying section, and a first helical blade and a second helical blade which are distributed at an interval in the axial direction of the spraying section are provided on the periphery of the spraying section, with the helical direction of the first helical blade being opposite to the helical direction of the second helical blade. During an acid-hydrocarbon separation process, by using the mixer of the present invention, the amount of alkali liquor used in an alkali washing process and the salt content in washing water produced after water washing can be greatly reduced.

IPC Classes  ?

• B01F 23/45 - Mixing liquids with liquidsEmulsifying using flow mixing
• C10G 19/02 - Refining hydrocarbon oils, in the absence of hydrogen, by alkaline treatment with aqueous alkaline solutions
• C10G 31/08 - Refining of hydrocarbon oils, in the absence of hydrogen, by methods not otherwise provided for by treating with water
• C10G 53/02 - Treatment of hydrocarbon oils, in the absence of hydrogen, by two or more refining processes plural serial stages only

Abstract

Disclosed in the present invention are a preparation method for high-purity lactide and the use of the high-purity lactide in polylactic acid synthesis. The preparation method comprises the following steps: (1) subjecting a lactate A and a long-chain alkanol to dealcoholization in the presence of a catalyst at 120-190°C to generate a lactic acid long-chain alkyl ester B; (2) continuously subjecting a lactic acid long-chain alkyl ester B mixed system obtained in step (1) to reduced pressure distillation under the conditions of 200-260°C and 0.1-0.5 kPa, so as to obtain a distillate; and (3) firstly subjecting the distillate in step (2) to solid-liquid separation to obtain a solid lactide phase, and then subjecting the solid phase to liquid-liquid extraction, so as to obtain lactide; or directly subjecting the distillate in step (2) to liquid-liquid phase separation, so as to obtain a high-purity lactide. The preparation method of the present invention has a simple and convenient process flow and a low operation cost, and the purity of the obtained lactide is higher and is not lower than 98%.

IPC Classes  ?

• C07D 319/12 - 1,4-DioxanesHydrogenated 1,4-dioxanes not condensed with other rings
• C08G 63/08 - Lactones or lactides
• C08G 63/85 - Germanium, tin, lead, arsenic, antimony, bismuth, titanium, zirconium, hafnium, vanadium, niobium, tantalum, or compounds thereof

Abstract

A transcription regulation system based on CRISPRi and CRISPRa, and an establishment method therefor and the use thereof. The system is a new transcription regulation system which has high expression intensity, a low leakage level and is flexible and programmable. Provided is a method for achieving high-intensity and low-leakage expression of a gene by means of the transcription regulation system, wherein a high-intensity transcription level is achieved while suppressing background expression by means of synergistic regulation on downstream signaling effect devices by means of CRISPRi and CRISPRa dev ices. The new transcription regulation system can obtain, by means of loading different input promoters, a new expression system for responding to a specific signal, and has application value in the development and establishment of an efficient heterologous protein expression platform and a microbial cell factory.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host

Abstract

Disclosed in the present invention are a compound as shown in formula (I) and an application thereof as an S1PR regulator, especially an S1PR4 agonist. The compound of the present invention can treat related diseases mediated by S1PR4 and mutants thereof, especially autoimmune diseases.

IPC Classes  ?

• C07D 205/04 - Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
• C07D 207/09 - Radicals substituted by nitrogen atoms not forming part of a nitro radical
• C07D 211/28 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
• C07C 251/48 - Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
• A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

Disclosed are a compound as shown in formula I and an application thereof as an S1PR regulator, especially a selective S1PR4 agonist in the treatment of a muscle disease. The compound can treat related diseases mediated by S1PR4 and mutants thereof. < img file = "PCT/CN2024123498-ISRE-I0000001 JPG" he = "15.08" img-content = "drawing" img-format = "jpg" in line = "YES" orientation = "portraitit" wi = "37.57"/>

IPC Classes  ?

• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
• A61K 31/401 - ProlineDerivatives thereof, e.g. captopril
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

A preparation method of a collagen material stripped from an electrode and a use of the collagen material are provided. The preparation method of a collagen material stripped from an electrode includes the following step: subjecting a collagen solution including hydrogen peroxide and/or acetic acid to electro-deposition (EDP) to obtain the collagen material on the electrode. The preparation method can lead to a collagen material directly on a surface of an electrode.

IPC Classes  ?

• C25D 9/02 - Electrolytic coating other than with metals with organic materials
• A61L 27/24 - Collagen
• A61L 27/52 - Hydrogels or hydrocolloids
• C25B 3/09 - Nitrogen containing compounds
• C25B 15/02 - Process control or regulation
• C25D 13/06 - Electrophoretic coating characterised by the process with organic material polymers
• C25D 17/10 - Electrodes

Abstract

Provided is a method for efficiently synthesizing an α,ω-diamine, comprising the following steps: (1) using an α,ω-dicarboxylic acid as a substrate, and synthesizing an ω-amino fatty acid under catalysis of a catalyst containing a first carboxylic acid reductase mutant; and (2) using an α,ω-dicarboxylic acid and the ω-amino fatty acid as substrates, synthesizing an α,ω-diamine under catalysis of a catalyst containing a second carboxylic acid reductase mutant, the first carboxylic acid reductase mutant having enhanced catalytic activity on the substrate α,ω-dicarboxylic acid and lowered catalytic activity on the ω-amino fatty acid, and/or, the second carboxylic acid reductase mutant having enhanced catalytic activity on both the substrates α,ω-dicarboxylic acid and ω-amino fatty acid. A method for efficiently synthesizing an ω-amino fatty acid is provided. Further disclosed are a series of carboxylic acid reductase mutants and the use thereof for the synthesis of an ω-amino fatty acid and an α,ω-diamine.

IPC Classes  ?

• C12P 13/00 - Preparation of nitrogen-containing organic compounds
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/53 - Oxidoreductases (1)
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12R 1/19 - Escherichia coli

Abstract

The present invention relates to the technical field of DNA synthesis, and provides a method for preparing a stable isotope labeled single-stranded DNA (ssDNA) by a biological fermentation method. According to the method of the present invention, a target sequence of an ssDNA is repeatedly tandem to a high-copy-number vector, and a site of a first restriction enzyme and a site of a second restriction enzyme are respectively added at 5' and 3' ends of the target sequence, a recombinant vector is subjected to enzyme digestion to obtain an asymmetric double-stranded DNA structure, and then two ssDNAs having different lengths are obtained by means of denaturation and separation, wherein the two ssDNAs include a 15N- or 1344Cl labeled by relatively cheap 15N, and/or 13C-labeled glucose as a unique carbon source, so that the synthesis costs can be effectively reduced.

IPC Classes  ?

• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

A digital twin-based pressure vessel safety evaluation and risk warning method includes steps: S1, determine a damage mode of pressure vessel; S2, design an overall plan of pressure vessel safety evaluation and risk warning; S3, simplify physical model of the pressure vessel and build a simplified physical model based on designed overall plan; S4, obtain load condition parameters during actual service of the pressure vessel; S5, determine material performance parameters of the pressure vessel; S6, build a digital twin model of pressure vessel safety evaluation and risk warning; S7, obtain a full-field damage distribution cloud map of the pressure vessel; S8, compare the full-field damage distribution cloud map and strength requirement of material of pressure vessel, if the strength requirement is met, conduct a safety evaluation at next time node according to subsequent needs of user, and if the strength requirement is not met, output a pressure vessel risk warning.

IPC Classes  ?

• G06F 30/17 - Mechanical parametric or variational design
• G06F 30/23 - Design optimisation, verification or simulation using finite element methods [FEM] or finite difference methods [FDM]

Abstract

Provided is a method for preparing stable isotope-labeled single-stranded DNA (ssDNA) by biosynthesis with E. coli, and the 15NH4Cl or 13C-Glcose is used as the only nitrogen or carbon source, which may significantly reduce costs. In the method of the present disclosure, the target sequence of ssDNA is tandemly duplicated on a high-copy vector, a site for a first restriction endonuclease and a site for a second restriction endonuclease are added to the 5′ and 3′ ends of the target sequence, respectively, and the recombinant vector is digested to obtain an asymmetric double-stranded DNA structure, which is then isolated by denaturation to obtain two ssDNAs of unequal lengths, including 15N- or 13C-labeled target ssDNA. The method of the present disclosure is able to effectively increase the yield of ssDNA, thereby improving the efficiency of in vitro synthesis of isotope labeled ssDNA.

IPC Classes  ?

• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli

Abstract

A fruit juice beverage capable of reducing sugar and enhancing sweetness by utilizing sweet orange aroma substances, and a preparation method therefor. The fruit juice beverage comprises, in percentage by mass, 0.05%-0.3% of linalool, 0.025%-0.3% of geraniol, 0.025%-0.3% of limonene, 0.025%-0.3% of sinensal, 0.025%-0.3% of citronellal, 0.025%-0.3% of octanal, 0.025%-0.3% of citral, 0.01%-0.3% of caryophyllene, and 1%-10% of sucrose. By controlling the concentration of sucrose and the concentrations of eight flavoring substances, i.e., limonene, linalool, sinensal, geraniol, octanal, citral, caryophyllene, and citronellal in the beverage, the effects of reducing sugar and enhancing sweetness are achieved.

IPC Classes  ?

• A23L 2/02 - Non-alcoholic beveragesDry compositions or concentrates thereforPreparation or treatment thereof containing fruit or vegetable juices
• A23L 2/52 - Adding ingredients
• A23L 2/60 - Sweeteners

Abstract

3 containing cyano group and an electron-donating group methoxy group. In the presence of HSA or BSA, the detection group is cut off to form a parent structure that exposes atomic oxygen anions and is activated under external light irradiation, the luminescent probe can be used in solution or cells, when detecting HSA or BSA, the luminescent probe has obvious chemiluminescence characteristics, which can sensitively distinguish HSA and BSA, quantitatively analyze HSA and BSA, and determine the mixing ratio of HSA and BSA at the same time, and the luminescent probe has been successfully used for cell fluorescence imaging.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C07D 309/34 - Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
• C07D 407/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Provided are a twist-bend nematic (NTB) LC dimer-based material and use thereof, and an LC-based cholesteric heliconical (CH) material and use thereof. The NTB LC dimer-based material is at least one selected from the group consisting of CBnCB, CBnOCB, and CBOnOCB, with n being a positive integer of 3 to 15. Based on ultra-stable properties of the material, the disclosure further provides the LC-based CH material, which uses the LC dimer-based material as a key raw material and integrates a conventional nematic LC monomer material and a chiral molecule.

IPC Classes  ?

• C09K 19/12 - Non-steroidal liquid crystal compounds containing at least two non-condensed rings containing at least two benzene rings at least two benzene rings directly linked, e.g. biphenyls
• C09K 19/02 - Liquid crystal materials characterised by optical, electrical or physical properties of the components, in general
• C09K 19/20 - Non-steroidal liquid crystal compounds containing at least two non-condensed rings containing at least two benzene rings linked by a chain containing carbon and oxygen atoms as chain links, e.g. esters

Abstract

A piezoelectric sensor is provided. The piezoelectric sensor comprises a first base, a first conductive layer adjacent to the first base, a second base, a second conductive layer adjacent to the second base; and a first structure between the first conductive layer and the second conductive layer. The first structure comprises a first layer with a first carbon-based material and a plurality of second structures with piezoelectricity. Each of the plurality of second structures comprises a second layer with a second carbon-based material and a third layer adjacent to the second layer. The third layer comprises a material of two-dimensional crystals of unconventional stoichiometries such as Na2Cl crystals.

IPC Classes  ?

• G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elementsTransmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means

Abstract

The present invention provides a continuous preparation method for dolutegravir, comprising the steps of: pumping a feed liquid A and a feed liquid B into a first microreactor, and carrying out an addition reaction to obtain a first addition product; pumping a feed liquid J and a feed liquid C into a second microreactor, and carrying out a cyclization reaction to obtain a first cyclization product; pumping a feed liquid K and a feed liquid D into a third microreactor, and carrying out an addition reaction to obtain a second addition product; pumping a feed liquid L and a feed liquid E into a fourth microreactor, and carrying out a hydrolysis reaction to obtain a hydrolysate; pumping a feed liquid M and a feed liquid F into a fifth microreactor, and carrying out a cyclization reaction to obtain a second cyclization product; pumping a feed liquid N and a feed liquid G into a sixth microreactor, and carrying out an amide reaction to obtain an amide product; and pumping a feed liquid O and hydrogen into a seventh microreactor, and carrying out a reduction reaction to obtain a dolutegravir crude product.

IPC Classes  ?

• C07D 498/14 - Ortho-condensed systems
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• B01J 4/02 - Feed devicesFeed or outlet control devices for feeding measured quantities of reagents
• B01J 4/00 - Feed devicesFeed or outlet control devices
• A61P 31/18 - Antivirals for RNA viruses for HIV

Abstract

TBTB phase state thereof is free of any crystallization when stored at room temperature for 300 days or more. On the basis of the above ultra-stable material properties, the present invention further provides a liquid crystal oblique helicoidal material, wherein the liquid crystal dimer material is used as the core raw material; a conventional nematic phase liquid crystal material and chiral molecules are fused; the phase state temperature interval of the material covers room temperature, i.e. 25°C; and the liquid crystal oblique helicoidal material is extremely stable, is free of crystallization when stored for 400 days or more, has stable physical parameters, and satisfies the requirement for stable and reliable electric-field modulation performance.

IPC Classes  ?

• C09K 19/44 - Mixtures of liquid crystal compounds covered by two or more of the preceding groups containing compounds with benzene rings directly linked
• G02F 1/13 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells
• C09K 19/14 - Non-steroidal liquid crystal compounds containing at least two non-condensed rings containing at least two benzene rings linked by a carbon chain

Abstract

The present invention relates to a method for inhibiting biogenic hydrogen sulfide in oilfields. A synergistic inhibition system combination agent containing Geobacillus strain GW1 is added into oilfield systems, wherein the strain GW1 has been deposited in China General Microbiological Culture Collection Center on Oct. 20, 2021, and has the deposit number of CGMCC No. 23631.

IPC Classes  ?

• C09K 8/54 - Compositions for in situ inhibition of corrosion in boreholes or wells
• C12N 1/20 - BacteriaCulture media therefor
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12R 1/01 - Bacteria or actinomycetales

Abstract

The present invention relates to a method for producing and preparing long-chain α-olefins. Specifically, polyethylene is used as a raw material, and is subjected to thermal cracking in a superheated water vapor environment. A mixed system of polyethylene and pressurized superheated water vapor is rapidly preheated, and is then subjected to thermal cracking, thereby finishing the efficient conversion of polyethylene into long-chain α-olefins and other co-products (long-chain alkanes, long-chain internal olefins, etc.). The yield of C7-C30 long-chain α-olefins in the product can reach 30%-70% or higher. The present invention not only provides a new raw-material route for the production and preparation of long-chain α-olefins, but also provides a way for the conversion of waste polyethylene into high-added-value long-chain α-olefins.

IPC Classes  ?

• C10G 9/00 - Thermal non-catalytic cracking, in the absence of hydrogen, of hydrocarbon oils
• C08J 11/14 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with steam or water
• C08L 23/06 - Polyethene

Abstract

A double-sided ultrasonic rolling cooperative strengthening system and a control method thereof are provided. The system includes a first mechanical arm subsystem, a second mechanical arm subsystem, a first ultrasonic rolling strengthening subsystem, a second ultrasonic rolling strengthening subsystem and a servo turntable (13); the servo turntable (13) is configured to fix a blade to be processed; the first ultrasonic rolling strengthening subsystem is provided at an end of the first mechanical arm subsystem; and the second ultrasonic rolling strengthening subsystem is provided at an end of the second mechanical arm subsystem. The way that the mechanical arm is equipped with an ultrasonic rolling strengthening device improves a degree of freedom of processing the blade, and the first mechanical arm subsystem, the second mechanical arm subsystem, the first ultrasonic rolling strengthening subsystem, the second ultrasonic rolling strengthening subsystem and the servo turntable (13) are provided to cooperate to realize double-sided processing.

IPC Classes  ?

• B21B 11/00 - Subsidising the rolling processes by subjecting rollers or work to vibrations
• B21B 13/00 - Metal-rolling stands, i.e. an assembly composed of a stand frame, rolls, and accessories
• B21B 13/14 - Metal-rolling stands, i.e. an assembly composed of a stand frame, rolls, and accessories having counter-pressure devices acting on rolls to inhibit deflection of same under load
• B23P 9/02 - Treating or finishing by applying pressure, e.g. knurling
• C21D 7/04 - Modifying the physical properties of iron or steel by deformation by cold working of the surface
• C22F 1/00 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
• C22F 3/00 - Changing the physical structure of non-ferrous metals or alloys by special physical methods, e.g. treatment with neutrons

Abstract

A water jet strengthening and polishing integrated system for blades of a blisk includes a vibration polishing unit and a water jet strengthening unit. The vibration polishing unit includes a vibration polishing bath, the vibration polishing bath is internally provided with a clamp for clamping the blisk, and vibration motors for driving the vibration polishing bath to vibrate are installed on the vibration polishing bath. Top ends of support springs are fixedly connected with the vibration polishing bath, and bottom ends of the support springs are fixedly connected with a workbench. The water jet strengthening unit includes a water jet strengthening device for carrying out water jet strengthening on the blades of the blisk and a driving mechanism for clamping the water jet strengthening device and capable of driving the water jet strengthening device to move in any direction in space.

IPC Classes  ?

• B24B 1/04 - Processes of grinding or polishingUse of auxiliary equipment in connection with such processes subjecting the grinding or polishing tools, the abrading or polishing medium or work to vibration, e.g. grinding with ultrasonic frequency
• B24B 19/14 - Single purpose machines or devices for particular grinding operations not covered by any other main group for grinding turbine blades, propeller blades or the like
• B24B 31/00 - Machines or devices designed for polishing or abrading surfaces on work by means of tumbling apparatus or other apparatus in which the work or the abrasive material is looseAccessories therefor
• B24B 31/06 - Machines or devices designed for polishing or abrading surfaces on work by means of tumbling apparatus or other apparatus in which the work or the abrasive material is looseAccessories therefor involving oscillating or vibrating containers
• B24B 31/12 - AccessoriesProtective equipment or safety devicesInstallations for exhaustion of dust or for sound absorption specially adapted for machines covered by group
• B24C 3/22 - Apparatus using nozzles
• B24C 3/28 - Apparatus using nozzles
• B24C 5/00 - Devices or accessories for generating abrasive blasts

Abstract

A compound as represented by formula I, or an optical isomer, a cis-trans isomer or a pharmaceutically acceptable salt thereof, and a preparation and the use thereof. The compound as represented by formula I can provide polymyxin a significant synergistic effect with regard to resisting various gram-negative bacteria, and can be applied to the treatment of infections caused by polymyxin-insensitive bacteria or drug-resistant bacteria.

IPC Classes  ?

• A61K 31/426 - 1,3-Thiazoles
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/42 - Oxazoles
• A61K 31/4168 - 1,3-Diazoles having a nitrogen atom attached in position 2, e.g. clonidine
• C07D 277/42 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61P 31/04 - Antibacterial agents

Abstract

The present invention relates to a management method and a device for hazardous chemicals and a construction method of a management database. The construction method comprises following steps: determining a plurality of entities involved in entire lifecycle of hazardous chemicals; classifying the plurality of entities to define a plurality of entity classes involved in the management database; defining a plurality of relationship classes according to one or more relationships involved between every two of the entity classes; using the relationship from one or more of the relationship classes to constrain the relationships between every two entities, so as to construct an ontology of the database; and importing actual data of the hazardous chemicals throughout their entire lifecycle into the ontology, so as to carry out instantiation of the ontology. By implementing this construction method, a management database for hazardous chemicals can be obtained, which can break the island phenomenon of multi-field data by integrating and fusing the multi-filed data throughout the entire lifecycle of hazardous chemicals, thereby achieving the effects of reasonable resource allocation, dynamic warning and supervision, and emergency linkage.

IPC Classes  ?

• G06F 16/28 - Databases characterised by their database models, e.g. relational or object models

Abstract

A system for testing fatigue performance of material in low-temperature liquid hydrogen environment, which relates to the technical field of mechanical property test platforms, includes a jacket cover. A hydrogen sensor is provided at the top of and within the jacket cover; a rack, a liquid hydrogen tank and a liquid nitrogen tank are provided in the jacket cover; a loading mechanism and a liquid hydrogen containing mechanism are provided on the rack, the loading mechanism is connected to the rack, and the bottom of the loading mechanism extends into the liquid hydrogen containing mechanism; the liquid hydrogen tank and the liquid nitrogen tank both communicate with the liquid hydrogen containing mechanism; and the loading mechanism is configured for providing tension or pressure to a sample. The liquid hydrogen containing mechanism is provided with a cooling channel located around a sealing gasket, the cooling channel communicates with a thermostat.

IPC Classes  ?

• G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces

Abstract

The present invention provides a method for integrated utilization of a calcium chloride solution and CO2. In this method, with the calcium chloride solution and the CO2 being taken as raw materials, a water-soluble amine is added as an auxiliary agent to promote the occurrence of a mineralization reaction. As a result of crystallization following the reaction, calcium carbonate and a solution of a hydrochloride of the water-soluble amine are obtained. After the reaction is completed, the water-soluble amine is regenerated by subjecting a liquid phase resulting from separation to bipolar membrane electrodialysis, and dilute hydrochloric acid is obtained as a by-product at the same time. The method provides a novel perspective and approach to integrated utilization of calcium chloride-containing liquid waste and flue gas CO2. The water-soluble amine allows excellent mineralization, and the bipolar membrane electrodialysis enables excellent regeneration of the amine. By means of process regulation, a calcium carbonate product of high value with controlled morphology and particle size can be obtained. For applications equipped with a lime kiln and allowing recycling of calcium carbonate, such as the ammonia-soda industry, the present invention also provides a combined cycle process for carbon and calcium resources, in which calcium carbonate produced by a mineralization reaction is calcined in lieu of limestone used in the soda production process to provide the soda production process with CO2 and milk of lime, enabling recycling of carbon and calcium resources in an ammonia soda plant. The entire process is free of waste discharge, showing a promising prospect of application. It is of great significance to the fields of calcium chloride-containing liquid waste disposal and carbon emission reduction.

IPC Classes  ?

• C01F 11/18 - Carbonates
• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• C02F 103/34 - Nature of the water, waste water, sewage or sludge to be treated from the chemical industry not provided for in groups

Abstract

This invention provides a method for synthesizing glycolide using methyl glycolate as a raw material, comprising two steps as illustrated in the following reaction formulas: This invention provides a method for synthesizing glycolide using methyl glycolate as a raw material, comprising two steps as illustrated in the following reaction formulas: This invention provides a method for synthesizing glycolide using methyl glycolate as a raw material, comprising two steps as illustrated in the following reaction formulas: wherein, the ROH represents a straight/branched chain alcohol, acid or ester containing 18-30 carbons and at least one hydroxyl group. The method for glycolide synthesis disclosed in the present invention manages to maintain a low viscosity within the reaction system by introducing a high-boiling alcohol into the reaction system to form a larger alkoxy glycolate exhibiting a significantly lower molecular weight compared to the typical glycolic acid oligomers utilized in the conventional process. Thus the challenges of coking and inefficient heat transfer encountered in traditional glycolide synthesis routes are effectively addressed.

IPC Classes  ?

• C07D 319/12 - 1,4-DioxanesHydrogenated 1,4-dioxanes not condensed with other rings
• C07C 67/02 - Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification

Abstract

An efficient and economical method for synthesizing Fasudil hydrochloride includes the synthesis route starts with inexpensive and readily available ethylenediamine as the starting material, obtains intermediate tert butyl-(N-(2-aminoethyl)-5-isoquinoline sulfonamide) carbamate (5) through sulfonylation and Boc protection, and then obtains Fasudil hydrochloride through a stacking process, which includes four steps: nucleophilic substitution, deprotection, cyclization, and salt formation. The total yield of Fasudil hydrochloride (1) is 67.1%, with a purity of up to 99.94%. Compared with traditional processes, the route avoids the use of expensive homopiperazine and its derivatives as synthetic intermediates. The advantages of the process include cheap and easy to obtain raw materials, simple operation, low cost, environmental friendliness, and suitability for industrial production.

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention discloses a method for recycling a spent lithium-ion battery, including the following steps: sandwiching a cathode of the spent lithium-ion battery with a conductive acid-resistant material as a cathode of a primary battery system; sandwiching an anode of the spent lithium-ion battery with a conductive acid-resistant material as an anode of the primary battery system; injecting an acid solution into a chamber of the primary battery system; and carrying out, after an electrochemical reaction is completed, solid-liquid separation on a mixed liquor in the chamber. The present invention further discloses an electrochemical system for recycling a spent lithium-ion battery. The method for recycling a spent lithium-ion battery in the present invention requires only dismantlement of cathode and anode materials, without a series of complex pretreatment operations on the cathode materials of the spent lithium-ion battery. In addition, by the method, the cathodes and anodes of the spent lithium-ion battery can be recycled at the same time, and valuable elements can be separated, which is greatly improved compared with the electrolytic leaching method. Moreover, there is no need to add an external power supply, which saves energy and can also output electricity.

IPC Classes  ?

• C25C 1/08 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of iron group metals, refractory metals or manganese of nickel or cobalt
• C21B 15/00 - Other processes for the manufacture of iron from iron compounds
• C22B 3/00 - Extraction of metal compounds from ores or concentrates by wet processes
• C22B 3/04 - Extraction of metal compounds from ores or concentrates by wet processes by leaching
• C22B 3/06 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in inorganic acid solutions
• C22B 3/08 - Sulfuric acid
• C22B 3/10 - Hydrochloric acid
• C22B 3/16 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in organic solutions
• C22B 3/22 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• C22B 26/12 - Obtaining lithium
• C22B 47/00 - Obtaining manganese
• C25C 1/10 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of iron group metals, refractory metals or manganese of chromium or manganese
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

Disclosed in the present invention are a pharmaceutical composition of an SGLT2 inhibitor and menthol and a use thereof in the preparation of drugs for preventing, ameliorating, and/or treating heart diseases. The pharmaceutical composition involved in the present invention has a myocardial cell protection effect, synergistically reduces intracellular calcium ion concentration, synergistically promotes fatty acid metabolism, has advantages compared with a single medication, and can be used for preparing medicines for treating, ameliorating, and/or preventing heart failure, coronary heart disease, myocardial infarction, hypertension heart disease, etc.

IPC Classes  ?

• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/045 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates
• A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
• A61P 9/04 - Inotropic agents, i.e. stimulants of cardiac contractionDrugs for heart failure

Abstract

The disclosure relates to a construction method and device for a chemical knowledge graph, an intelligent question answering method and device for chemical knowledge, and two computer-readable storage media. The construction method comprises the following steps: obtaining knowledge data in chemical industry field; pre-processing the knowledge data to obtain entity data and property data related to chemical knowledge; determining a preliminary knowledge representation according to the entity data and the property data; performing entity alignment on the preliminary knowledge representation to obtain a standard knowledge representation; and constructing the chemical knowledge graph according to the standard knowledge representation. The construction method for a chemical knowledge graph can automatically collect relevant knowledge in the chemical industry to construct a chemical knowledge graph on basis of natural language processing, big data and artificial intelligence technology, thereby greatly improving the construction speed of the chemical knowledge graph and reducing the manual construction cost of the chemical knowledge graph.

IPC Classes  ?

• G06N 5/04 - Inference or reasoning models
• G06N 5/022 - Knowledge engineeringKnowledge acquisition

Abstract

The present invention relates to a pesticide emulsion having a liquid crystal structure, a preparation method therefor and a use thereof. The emulsion comprises a pesticide active ingredient and a liquid crystal emulsifier. According to the present invention, by constructing an "onion-like" layered structure of an oil layer/liquid crystal layer/water layer (O/LC/W), the pesticide is limited and solubilized between the water layer and the oil layer, and the drug loading ratio is approximately 100%. The liquid crystal pesticide emulsion of the present invention involves a simple and green preparation process, can be prepared on a large scale, and is adapted to various pesticides; the pesticide emulsion is superior to similar traditional water dispersible pesticide formulations in terms of dispersion stability, target deposition efficiency and the like, and is particularly suitable for use in the actual complex environment.

IPC Classes  ?

• A01N 25/04 - Dispersions or gels

Abstract

The present invention relates to an arginine fluorescent optical probe. Specifically, the present invention provides an arginine-sensitive polypeptide, wherein the arginine-sensitive polypeptide is a variant of an arginine binding protein, and formula (1) thereof has a sequence as shown in SEQ ID NO: 1 and has mutations at one, two, or three or more sites selected from the following. Compared with a probe formed by a wild arginine-sensitive polypeptide, the fluorescent probe of the present invention has greater dynamic changes in fluorescence and better specificity, and can be used for the high-throughput and quantitative detection of arginine inside and outside of cells.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 19/00 - Hybrid peptides
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/62 - DNA sequences coding for fusion proteins
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

A method and a system for evaluating stress corrosion cracking sensitivity of a welded component are provided. The method includes performing an in-situ tensile test on a welded component to be tested to obtain mechanical property parameters of each zone of the welded component to be tested; determining sizes and positions of notch specimens of the welded component to be tested by means of a finite element simulation method; processing specimens of the welded component to be tested; respectively performing a slow strain rate tensile test on the specimens of the welded component to be tested until the specimens are fractured in both an inert environment and a test environment, so as to obtain reductions of area of notch roots of the specimens of the welded component to be tested; and calculating stress corrosion cracking sensitivities of various zones of the welded component to be tested.

IPC Classes  ?

• G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
• G01N 3/06 - Special adaptations of indicating or recording means
• G01N 21/84 - Systems specially adapted for particular applications
• G01N 23/2251 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material using electron or ion microprobes using incident electron beams, e.g. scanning electron microscopy [SEM]

Abstract

Disclosed is a method for preparing cellulose and lignin oil by depolymerizing lignocellulose without exogenous hydrogen, including: performing reaction on the lignocellulose dispersed into an aqueous medium at 120° C. to 180° C. under the action of a catalyst; and separating a reaction product to obtain the cellulose and the lignin oil. The catalyst includes a carrier and an active ingredient loaded on the carrier, where the active ingredient is selected from one of platinum, palladium, ruthenium and nickel; the carrier is selected from one of a metal oxide, a metal composite material, silicon dioxide, nitrogen-doped carbon, molybdenum carbide and molybdenum nitride; and the metal oxide is selected from one of niobium oxide, tantalum oxide, tungsten oxide, zirconium oxide, aluminum oxide, titanium dioxide and molybdenum oxide.

IPC Classes  ?

• C08H 8/00 - Macromolecular compounds derived from lignocellulosic materials
• B01J 23/42 - Platinum
• B01J 23/44 - Palladium
• B01J 23/46 - Ruthenium, rhodium, osmium or iridium
• B01J 23/56 - Platinum group metals
• B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
• C07G 1/00 - Low-molecular-weight derivatives of lignin
• D21C 5/00 - Other processes for obtaining cellulose, e.g. cooking cotton linters

Abstract

Provided is a method for preparing cellulose and lignin oil from exogenous-hydrogen-free depolymerized lignocellulose, comprising: reacting lignocellulose dispersed in an aqueous medium at 120-180 ℃ in the presence of a catalyst; and separating the reaction products to give cellulose and lignin oil. The catalyst comprises a carrier and an active component loaded on the carrier. The active component is selected from one of platinum, palladium, ruthenium, and nickel, and the carrier is selected from one of metal oxide, metal composite material, silicon oxide, nitrogen-doped carbon, molybdenum carbide, and molybdenum nitride. The metal oxide is selected from one of niobium oxide, tantalum oxide, tungsten oxide, zirconium oxide, aluminum oxide, titanium oxide, and molybdenum oxide. The metal composite material is selected from one of a lanthanum-nickel composite material, a magnesium-aluminum composite material, a cobalt-aluminum composite material, a zinc-aluminum composite material, an iron-aluminum composite material, and a nickel-aluminum composite material. The lignocellulose materials (such as hardwood, softwood, and herbaceous plants), without the need for additional hydrogen sources, are deconstructed and depolymerized in water, so as to give lignin oil and preserved cellulose.

IPC Classes  ?

• C07C 37/00 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
• C07C 39/00 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
• B01J 23/40 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of noble metals of the platinum group metals
• B01J 23/42 - Platinum
• B01J 23/44 - Palladium
• B01J 23/46 - Ruthenium, rhodium, osmium or iridium

Abstract

Provided are a thermal barrier coating and a preparation method thereof, which belong to the field of coating technology. The thermal barrier coating has a double-layer coating structure, and includes an intermediate layer attached to a surface of a metal bonding layer, and a top layer, wherein the intermediate layer is formed by atmospheric plasma spraying YSZ porous microspheres, and the top layer is formed by atmospheric plasma spraying Yb—Gd codoped YSZ porous microspheres; the intermediate layer is in contact with the surface of the metal bonding layer, and the top layer is directly exposed to a high-temperature gas environment.

IPC Classes  ?

• C09D 1/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on inorganic substances
• C23C 4/02 - Pretreatment of the material to be coated, e.g. for coating on selected surface areas
• C23C 4/06 - Metallic material
• C23C 4/11 - Oxides
• C23C 4/134 - Plasma spraying

Abstract

The present invention relates to a phosphoenolpyruvate optical probe. Specifically, the present invention provides a phosphoenolpyruvate optical probe, which comprises a phosphoenolpyruvate-sensitive peptide and an optically active peptide, wherein the optically active polypeptide is located within a sequence of the phosphoenolpyruvate-sensitive polypeptide.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

A method for synchronously extracting lithium and boron resources from a boron-rich lithium-containing system. The method comprises the following steps: S1, filling an adsorption device with Li/Al-LDHs serving as an adsorbent to form an adsorption bed layer, pumping a boron-rich lithium-containing adsorption liquid into the adsorption device from the lower end thereof, and enabling same to pass through the adsorption bed layer and then flow out from the upper end of the adsorption device; S2, after the adsorption is finished, rinsing, with water, the adsorption bed layer from the upper end of the adsorption device; S3, pumping a boron desorption liquid into the adsorption device from the lower end thereof, enabling same to pass through the adsorption bed layer, and then collecting the effluent at the upper end of the adsorption device; and S4, pumping the lithium desorption liquid into the adsorption device from the lower end thereof, enabling same to pass through the adsorption bed layer, and then collecting the effluent from the upper end of the adsorption device. Alternatively, step S4 can be performed prior to step S3.

IPC Classes  ?

• B01D 15/08 - Selective adsorption, e.g. chromatography
• B01J 20/08 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group comprising aluminium oxide or hydroxideSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group comprising bauxite
• B01J 20/04 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
• C22B 26/12 - Obtaining lithium
• C01B 35/00 - BoronCompounds thereof

Abstract

The present disclosure belongs to the technical field of packings, and in particular, to a packing element, a structured packing and an application of the structured packing. The packing element includes a collection-predistribution unit, a fluid uniform distribution unit, and an opening window unit that are sequentially arranged. The fluid uniform distribution unit includes a first substrate and a plurality of orifices arranged on the first substrate. Each orifice is circular and/or semicircular. Each orifice has an equivalent diameter of 1-5 mm. The opening window unit is provided with a plurality of windows, and each window has a length proportional to 0.5 power of the fluid viscosity. Fluid forms a confined free film in the window region of the opening window unit and wall-bounded film on the wall surface region.

IPC Classes  ?

• B01J 19/32 - Packing elements in the form of grids or built-up elements for forming a unit or module inside the apparatus for mass or heat transfer

Abstract

22, the crystal defect concentration and the lattice distortion degree are regulated and controlled by means of the doping amount of the rare earth oxides, and a completely stabilized cubic fluorite crystal structure is presented, so that no phase change occurs at room temperature to 1,600°C; and the present invention has the advantages of high toughness, CMAS corrosion resistance, ultra-high-temperature sintering resistance and a long service life.

IPC Classes  ?

• C04B 35/48 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates
• C04B 35/50 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on rare earth compounds
• C04B 35/622 - Forming processesProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
• C04B 35/626 - Preparing or treating the powders individually or as batches
• C23C 4/11 - Oxides
• C23C 4/134 - Plasma spraying

Abstract

The present invention relates to a fructose diphosphate optical probe. Specifically, provided in the present invention is a fructose diphosphate optical probe, which comprises a fructose-1,6-diphosphate sensitive polypeptide and an optically active polypeptide, wherein the optically active polypeptide is located within the sequence of a fructose-1,6-diphosphate sensitive polypeptide, the fructose-1,6-diphosphate sensitive polypeptide is a fructose-1,6-diphosphate binding protein or a functional variant thereof, and the optically active polypeptide is a fluorescent protein or a functional variant thereof. The fluorescent probe of the present invention has a large dynamic change in terms of fluorescence and a good specificity, and can be used for high-throughput and quantitative detection of fructose diphosphate inside and outside a cell.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 19/00 - Hybrid peptides
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
• C12R 1/19 - Escherichia coli

Abstract

The use of a sulfonated polysaccharide. The sulfonated polysaccharide has a strong capability of inhibiting SARS-CoV-2 from infecting host cells, and therefore can be used for preparing drugs for treating and/or preventing corona virus disease 2019.

IPC Classes  ?

• A61K 31/737 - Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
• A61K 31/722 - ChitinChitosan
• A61P 31/14 - Antivirals for RNA viruses

Abstract

2Cl crystals.

IPC Classes  ?

• H01L 41/113 - Piezo-electric or electrostrictive elements with mechanical input and electrical output
• G01L 1/16 - Measuring force or stress, in general using properties of piezoelectric devices
• H10N 30/30 - Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors
• H10N 30/853 - Ceramic compositions
• H10N 30/88 - MountsSupportsEnclosuresCasings

Abstract

A method for identifying microorganisms having an oil reservoir flooding function based on metagenomics and metatranscriptomics, which comprises the following steps: S1, extracting the total DNA and total RNA from a water sample of an oil reservoir; S2, sequencing the obtained total DNA and total RNA to obtain metagenomic and metatranscriptomic original data of the oil reservoir sample; and S3, analyzing metagenomic and metatranscriptomic results, and identifying microorganisms having a flooding function.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• G16B 10/00 - ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Abstract

An anti-fatigue and safety control method for ultra-long life service structures under extreme environment, comprising: judge the fatigue fracture mode in the long life stage of the service structure; according to the interaction principle of defect-matrix, obtain the internal defect induced fatigue cracking mechanism in ultra-high cycle regime under the service environment; considering the environmental factors, clarify the internal defect-matrix-environment interaction mechanism under service conditions and obtain the environmental weakening coefficient; considering the environmental factors, establish a fatigue life prediction model based on defect-load-life correlation under service conditions in ultra-high cycle regime; the process parameters of material metallurgy and manufacturing, design parameters of structural strength, structural service stress and environmental parameters are regulated based on the concept of integrated design/manufacturing.

IPC Classes  ?

• G06Q 10/0639 - Performance analysis of employeesPerformance analysis of enterprise or organisation operations
• G05B 23/02 - Electric testing or monitoring
• G06Q 10/067 - Enterprise or organisation modelling
• G06Q 50/04 - Manufacturing
• G06Q 50/26 - Government or public services

Abstract

Embodiments of the present disclosure relate to a D-amino acid oxidase mutant and application in preparing L-glufosinate thereof. The D-amino acid oxidase mutant has an amino acid substitution at at least one of position 62 and position 226 of an amino acid sequence of the D-amino acid oxidase mutant when compared to an amino acid sequence of a D-amino acid oxidase as set forth in SEQ ID NO. 1, the position 62 and position 226 being defined with reference to SEQ ID NO. 1, and the amino acid sequence of the D-amino acid oxidase mutant having at least 90% identity to SEQ ID NO. 1.

IPC Classes  ?

• C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
• C12N 9/08 - Oxidoreductases (1.), e.g. luciferase acting on hydrogen peroxide as acceptor (1.11)
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12P 13/04 - Alpha- or beta-amino acids

Abstract

Disclosed in the present invention are a piezoelectric porous support with an efficient osteogenesis-promoting effect and a preparation method therefor. The piezoelectric porous support is obtained by mixing a biological component with a piezoelectric component by means of a binder, sintering, and then carrying out polarization processing. The piezoelectric porous support of the present invention can efficiently immobilize and adsorb a bioactive protein factor, realizes effective slow release of a protein, and has piezoelectricity and osteogenic activity at the same time. Under the mutual cooperation of multiple effects such as the piezoelectric effect and porous structure of the support and the biological activity of the protein, the early response of bone marrow stromal stem cells is rapidly initiated, thereby promoting cell adhesion, proliferation, and osteogenic differentiation, which is of great significance for efficient and rapid repair of bone defects such as large segmental bone defects and bone nonunion.

IPC Classes  ?

• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/00 - Materials for prostheses or for coating prostheses

Abstract

Disclosed are a pyrrolopyrimidine derivative as an RSK inhibitor and use thereof. Specifically, disclosed are a compound represented by formula I, a pharmaceutical composition containing the compound of formula I, and use of the compound in the preparation of a medicament for treating an RSK-related disease or inhibiting RSK.

IPC Classes  ?

• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• C07D 487/04 - Ortho-condensed systems
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a pyridonopyrimidine derivative as an RSK protein kinase inhibitor and use thereof. Specifically, the present invention relates to a compound represented by formula I, a pharmaceutical composition comprising the compound represented by formula I, and use of the compound in preparing a medicament for treating an RSK-related disease or inhibiting RSK. Formula I.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• C07D 475/00 - Heterocyclic compounds containing pteridine ring systems
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

An anti-fatigue and safety regulation and control method for a service structure having an ultra-long service life in an extreme environment, the method comprising: determining a fatigue fracture mode of a service structure in a long service life stage; according to a defect-matrix interaction principle, obtaining a cracking mechanism of an ultra-high cycle internal fatigue defect in the service structure in an air environment; considering environmental factors, clarifying an internal defect-matrix-environment interaction mechanism of ultra-high cycle fatigue under service conditions and acquire an environmental weakening coefficient; establishing a theoretical model for ultra-high cycle fatigue service life prediction related to a defect-load-service life relationship under service conditions; and on the basis of the concept of design/manufacturing integration, regulating and controlling material metallurgy and manufacturing process parameters, structural strength design parameters, and structural service stress and environmental parameters. The method can enhance the collaboration between design and manufacturing, shorten design and manufacturing processes, effectively increase the fatigue resistance of materials and the structure, and ensure the long-period service safety of the structure.

IPC Classes  ?

• G01N 3/32 - Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces

Abstract

The present invention relates to a method and a kit for diagnosing MIDD. Specifically, provided is a method for diagnosing MIDD, which comprises the following steps: (1) detecting lactic acid in urine; and (2) comparing same with the control level. The method of the present invention is simple and fast, has accurate results, and can be used for point-of-care detection of patients with MIDD.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

The present disclosure provides a machine vision-based automatic focusing and automatic centering method and system, which belongs to the technical field of machine vision-based automatic control. An object stage is controlled to move in an imaging distance range of an electron microscope, and images scanned by the electron microscope when the object stage is at different imaging distances are acquired. The image definition of an object stage image is calculated according to a gray-scale value of each pixel in the object stage image, the imaging position when an image definition value is the maximum is determined, and the object stage is controlled to move to the position, so as to realize machine vision-based accurate focusing. After the accurate focusing is completed, the images that can clearly reflect the arrangement relationship between an indenter and a sample on the object stage are acquired by the electron microscope, and a midline of an indenter area and a midline of a sample area are aligned, so as to realize machine vision-based accurate centering, which avoids the problems of low efficiency and poor accuracy in manual focusing and centering, and improves the focusing and centering efficiency.

IPC Classes  ?

• H01J 37/21 - Means for adjusting the focus
• G06T 7/70 - Determining position or orientation of objects or cameras
• H01J 37/20 - Means for supporting or positioning the object or the materialMeans for adjusting diaphragms or lenses associated with the support

Abstract

The invention provides a device for enhancing liquid-liquid emulsification. The device includes a jet part and a mixing part connected to the jet part. The jet part includes a feed tee for feeding major and dispersed phases, wherein the feed tee includes a first port, a second port, and a third port. The first port is used for feeding the major phase, and the second port is equipped with an ejector for feeding the dispersed phase. The ejector consists of an ejector housing and an ejector inlet section, as well as a spiral structure, a flow-guided structure, and an ejector pin structure that are connected sequentially. The mixing part includes a mixer comprising a cylindrical mixer shell, a mixer inlet section, a mixer outlet section, as well as a spiral section, a cavity section, and a variable diameter section for enhancing emulsion breakup and dispersion. A method for enhancing liquid-liquid emulsification is also disclosed. The emulsion produced by the device and method of the invention is uniformly dispersed, has long stability, and the device has a compact structure and low energy consumption. It is particularly suitable for liquid-liquid emulsification processes in fields such as chemical industry, food, coatings, and cosmetics.

IPC Classes  ?

• B01F 23/41 - Emulsifying
• B01F 23/451 - Mixing liquids with liquidsEmulsifying using flow mixing by injecting one liquid into another
• B01F 25/20 - Jet mixers, i.e. mixers using high-speed fluid streams
• B01F 25/21 - Jet mixers, i.e. mixers using high-speed fluid streams with submerged injectors, e.g. nozzles, for injecting high-pressure jets into a large volume or into mixing chambers
• B01F 25/10 - Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
• B01F 25/4314 - Straight mixing tubes with baffles or obstructions that do not cause substantial pressure dropBaffles therefor with helical baffles
• B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles

Abstract

A polybutyrolactam-based degradable multi-layer composite film, consisting of an oxygen barrier layer, a bonding layer and a moisture barrier layer. The oxygen barrier layer is formed of polybutyrolactam, the bonding layer is formed of polyvinyl alcohol, and the moisture barrier layer is formed of a polyester hydrophobic biodegradable polymer. The multi-layer composite film shows excellent barrier properties, mechanical strength and toughness, and is widely applied in the field of biodegradable food packages.

IPC Classes  ?

• B32B 27/34 - Layered products essentially comprising synthetic resin comprising polyamides
• B32B 27/30 - Layered products essentially comprising synthetic resin comprising vinyl resinLayered products essentially comprising synthetic resin comprising acrylic resin
• B32B 27/36 - Layered products essentially comprising synthetic resin comprising polyesters
• B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
• B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
• B65D 65/40 - Applications of laminates for particular packaging purposes
• B29C 41/32 - Making multilayered or multicoloured articles

Abstract

A bilateral ultrasonic rolling collaborative strengthening system and a control method therefor. The system comprises a first mechanical arm subsystem, a second mechanical arm subsystem, a first ultrasonic rolling strengthening subsystem, a second ultrasonic rolling strengthening subsystem and a servo turntable (13), wherein the servo turntable (13) is used for fixing a blade to be machined; the first ultrasonic rolling strengthening subsystem is arranged at a tail end of the first mechanical arm subsystem; and the second ultrasonic rolling strengthening subsystem is arranged at a tail end of the second mechanical arm subsystem. The degree of freedom of blade machining is improved by means of using a mechanical arm to carry an ultrasonic rolling strengthening device; and the first mechanical arm subsystem, the second mechanical arm subsystem, the first ultrasonic rolling strengthening subsystem, the second ultrasonic rolling strengthening subsystem and the servo turntable (13) are configured to cooperate so as to achieve double-sided machining.

IPC Classes  ?

• C21D 7/04 - Modifying the physical properties of iron or steel by deformation by cold working of the surface
• C22F 1/00 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working

Abstract

A catalytic cracking unit key index modeling method based on time sequence feature extraction. The method comprises: step S1, obtaining catalytic unit production data for preprocessing; step S2, screening input feature variables by means of a random forest method, and generate sample data; step S3, dividing the sample data into different operation patterns on the basis of a principal component analysis method to form a plurality of corresponding sub-pattern samples; step S4, fusing relative position coding to obtain coding input information in each sub-pattern; step S5, constructing a multi-layer coding module on the basis of an attention mechanism and a feedforward neural network, and converting the output of the multi-layer coding module into product yield data; and step S6, adjusting some of model structure hyperparameters to generate a prediction model, predicting the product yield and processing the output data. According to the catalytic unit data model generated by the method, the prediction precision and stability of the product yield can be improved.

IPC Classes  ?

• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes
• G16C 20/70 - Machine learning, data mining or chemometrics
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

The disclosure provides a fluorescent sensor, comprising a) a responsive polypeptide, and b) an optically active polypeptide, wherein the optically active polypeptide is inserted into the responsive polypeptide. The present disclosure also relates to a nucleic acid sequence encoding the fluorescent sensor according to any embodiment, or a complementary sequence thereof. The disclosure also provides an expression vector comprising the nucleic acid sequence or a complementary sequence thereof of the disclosure operably linked to an expression control sequence. The disclosure also provides a cell containing the expression vector of the disclosure. The present disclosure also provides a method for preparing the fluorescent sensor of this disclosure, comprising the following steps: providing a host cell comprising an expression vector that expresses the fluorescent sensor of the disclosure, culturing the host cell under conditions suitable for the expression of the host cell, and separating the fluorescent sensor. The disclosure also provides uses of the fluorescent sensor described in the disclosure or the fluorescent sensor prepared according to the method of the disclosure in detecting BCAAs. In one embodiment, the branched chain amino acids are selected from leucine, isoleucine and valine. The detection can be conducted in vitro, in vivo, in situ, or at subcellular level. The disclosure also provides a kit, comprising the fluorescent sensor described in the disclosure or the fluorescent sensor prepared according to the method of the disclosure.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence

Abstract

A water jet strengthening and polishing integrated system for blades of a bladed disk, comprising a vibration polishing unit and a water jet strengthening unit. The vibration polishing unit comprises a vibration polishing tank (3), a clamp (6) used for clamping a bladed disk being provided in the vibration polishing tank (3), and vibration motors (32) used for driving the vibration polishing tank (3) to vibrate being installed on the vibration polishing tank (3). The top ends of support springs (31) are fixedly connected to the vibration polishing tank (3), and the bottom ends of the support springs (31) are fixedly connected to a workbench (21). The water jet strengthening unit comprises a water jet strengthening device (5) used for carrying out water jet strengthening on blades of the bladed disk (7) and a driving mechanism used for clamping the water jet strengthening device (5) and driving same to move in any direction of space. The present invention further comprises a method, comprising: filling the vibration polishing tank (3) with an abrasive liquid; the vibration motors (32) driving the vibration polishing tank (3) to vibrate so as to polish the blades, and simultaneously, the driving mechanism driving the water jet strengthening device (5) to move so as to perform water jet strengthening successively on all the blades of the bladed disk (7). The present invention effectively improves the surface strengthening quality and efficiency for the blades of the bladed disk (7).

IPC Classes  ?

• B24B 31/06 - Machines or devices designed for polishing or abrading surfaces on work by means of tumbling apparatus or other apparatus in which the work or the abrasive material is looseAccessories therefor involving oscillating or vibrating containers
• B24C 1/04 - Methods for use of abrasive blasting for producing particular effectsUse of auxiliary equipment in connection with such methods for treating only selected parts of a surface, e.g. for carving stone or glass
• B24C 1/08 - Methods for use of abrasive blasting for producing particular effectsUse of auxiliary equipment in connection with such methods for polishing surfaces, e.g. by making use of liquid-borne abrasives
• B24C 5/04 - Nozzles therefor
• C21D 7/06 - Modifying the physical properties of iron or steel by deformation by cold working of the surface by shot-peening or the like

Abstract

A compound represented by formula (I) or an isomer, a pharmaceutically acceptable salt, a hydrate, a solvate, or a prodrug thereof. The compound is a PROTAC molecule having excellent degradation activity on a CDK protein kinase, lays a substantive foundation for developing a drug capable of targeted degradation of CDK, and thus has great industrialization and commercialization prospects.

IPC Classes  ?

• C07D 475/00 - Heterocyclic compounds containing pteridine ring systems
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61P 35/00 - Antineoplastic agents

Abstract

(+)(-)(-/+)(-)(+)(-/+)(-/+), which represents the oil displacement effect of a biological composite oil displacement system. Compared with the prior art, the present invention is simple and rapid, and without the need of a large number of experiments, can judge whether two surfactants can be electrically complementary, and on this basis, rapidly screen out an effective combination of a surfactant and a lipopeptide, so as to construct a biological composite oil displacement system.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• E21B 43/22 - Use of chemicals or bacterial activity

Abstract

The present invention relates to a method for analyzing the distribution of water droplets in thickened oil. The method comprises: firstly, putting onto a glass slide an oil sample to be subjected to detection, and clamping and fixing same by means of another glass slide to obtain an oil sample plate to be subjected to detection; and then photographing said oil sample plate, and performing statistical processing on a photograph of said oil sample by using image J software to obtain the particle size distribution and volume distribution of water droplets in said oil sample. Compared with the prior art, the statistical method in the present invention has the advantages of the amount of samples required being small, the experimental instruments used being simple, and the time consumed for an operation process being short; the statistical method is suitable for compiling statistics of multiple samples, the experimental instruments, such as beakers and glass slides, used in the operation can all be wiped and cleaned for reuse, and main process parameters, such as temperature and pressure, are all in a normal and controllable state with a high safety factor; and the experiment operation process is safe and non-toxic.

IPC Classes  ?

• G01N 15/02 - Investigating particle size or size distribution
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry

Abstract

An efficient flotation reagent suitable for direct flotation production of potassium chloride, which reagent comprises a collecting agent and a foaming agent. The collecting agent is selected from one or more of amine nitrates, amine sulfates, amine acetates and amine formates; and the foaming agent is selected from one or more of alcohol ether substances comprising one hydroxyl group and two ether groups. A new flotation reagent is used to replace a traditional collecting agent octadecylamine and hydrochloric acid, and a foaming agent #2 oil, for direct flotation of potassium chloride, which overcomes the shortcoming of hydrochloric acid being required in an original reagent preparation process, eliminates environmental pollution resulting from the volatilization of #2 oil, improves the reagent collection performance, reduces the dosage of the reagent, improves the single-pass potassium recovery rate in the flotation process, and forms a chlorine-free potassium chloride flotation reagent system.

IPC Classes  ?

• B03D 1/018 - Mixtures of inorganic and organic compounds

Abstract

Disclosed are a polypeptide polymer-doped bone marrow cavity filler and the use thereof in the treatment of osteomyelitis, wherein the polypeptide polymer is used for being doped in a bone marrow cavity filler or preparing a bone marrow cavity filling antibacterial material for treating osteomyelitis, has efficient antibacterial activity on common staphylococcus aureus, etc., in osteomyelitis, is not easy to induce bacteria to generate drug resistance, has good biocompatibility in environments such as bone marrow and blood, has good stability, and still keeps activity after forming heat release and even the autoclaving of bone cement.

IPC Classes  ?

• A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
• A61L 27/56 - Porous or cellular materials

Abstract

The present invention relates to a high-strength absorbable composite active internal fixation device and a preparation method therefor. Specifically, the present invention discloses the internal fixation device and its preparation method, which possess excellent biological activity and mechanical properties.

IPC Classes  ?

• A61B 17/86 - Pins or screws
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/58 - Materials at least partially resorbable by the body
• A61L 31/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
• B29B 9/12 - Making granules characterised by structure or composition
• B29C 71/02 - Thermal after-treatment
• B29C 45/77 - Measuring, controlling or regulating of velocity or pressure of moulding material
• B29C 45/78 - Measuring, controlling or regulating of temperature
• B29C 48/92 - Measuring, controlling or regulating

Abstract

The present invention relates to a method for inhibiting biogenic hydrogen sulfide in an oil field. A synergistic inhibition system combination agent containing Bacillus licheniformis GW1 is added into an oil field system, wherein the Bacillus licheniformis GW1 has been deposited in the China General Microbiological Culture Collection Center on October 20, 2021, and has the deposit number of CGMCC No. 23631. Compared with the prior art, in the present invention, when Bacillus licheniformis GW1 and an activator nitrate are added, the inhibition rate of hydrogen sulfide can reach not less than 90.81%; on this basis, the inhibition effect is enhanced after the synergistic inhibitor is added, and the inhibition rate of hydrogen sulfide can reach 99.37% at most; and a system constructed by the inhibition bacterium, the activator and the synergistic inhibitor of the present invention can effectively reduce the content of hydrogen sulfide in the oil field system and has the advantages of a good inhibitory effect, low economic costs, and a simple injection system, etc.

IPC Classes  ?

• C09K 8/54 - Compositions for in situ inhibition of corrosion in boreholes or wells
• C12N 1/02 - Separating microorganisms from their culture media
• C12N 1/20 - BacteriaCulture media therefor

Abstract

The present disclosure relates to a method and apparatus for prolonging a continuous operation period of a methanol-to-olefins water washing process. The method may perform micro cyclone treatment on methanol-to-olefins washing water. The method may also deliver the washing water subjected to micro cyclone treatment and oil removal to a fluidized bed separator for treatment. The method may also adjust the backwash flow to release the intercepted catalyst powder and empty the dirt holding capacity of a pore. The method may also perform three-phase separation on a gas-liquid-solid mixture subjected to backwash, returning the obtained filter media to a particle bed layer, and respectively discharging a backwashing liquid a backwashing gas which comprise a catalyst. The method may also switch the fluidized bed separator to a normal working state, completing the active regeneration of the particle bed layer, and continuing to operate.

IPC Classes  ?

• C02F 1/40 - Devices for separating or removing fatty or oily substances or similar floating material
• C02F 1/16 - Treatment of water, waste water, or sewage by heating by distillation or evaporation using waste heat from other processes

Abstract

A water softening structure, which is used in a water softener, and comprises: a first-stage water softening unit group, which includes A water softening units connected in parallel, and the first-stage water softening unit group is connected in series to a second-stage water softening unit group, wherein A ≥ 1; the second-stage water softening unit group, which includes B water softening units connected in parallel, wherein B ≥ 1; a controller, which can disconnect, according to adsorption amounts of the water softening units, a certain water softening unit needing to be regenerated, connect in parallel a regenerated water softening unit to the second-stage water softening unit group, and at the same time, control to connect in parallel a certain water softening unit in the second-stage water softening unit group to the first-stage water softening unit group; and a switching apparatus, which is connected to each water softening unit, and can control, according to a controller instruction, each water softening unit to be connected in parallel to or be disconnected from a certain water softening unit group, wherein all the water softening units simultaneously run and are separately regenerated. The water softening structure can uninterruptedly supply water, and can significantly improve the utilization rates of resin and a regenerant, so as to significantly reduce the regeneration frequency of a device, thereby saving on use costs.

IPC Classes  ?

• C02F 1/42 - Treatment of water, waste water, or sewage by ion-exchange
• B01J 49/60 - Cleaning or rinsing ion-exchange beds
• B01J 49/75 - Regeneration or reactivation of ion-exchangersApparatus therefor of water softeners

Abstract

The application discloses a time-dependent local stress-strain method for high-temperature structural strength and service life analysis. The method is aimed at a load component under high-temperature conditions, and the load component has a structural discontinuity area. The method includes: a step for obtaining working conditions, a step for obtaining material parameters, an elastoplasticity analysis step, a limit analysis step, an elasticity analysis step, a boundary condition setting step, an iterative operation step, and a result integration step. The application also discloses time-dependent local stress-strain tool software for high-temperature structural strength and service life analysis. The tool software includes: a parameter acquisition assembly, a finite element modeling and operation assembly, an iterative operation assembly, and a result display assembly.

IPC Classes  ?

• G01N 3/06 - Special adaptations of indicating or recording means

Abstract

Provided are a dielectric material and a method for manufacturing the same. The dielectric material includes: subjecting a foamed sphere obtained by a primary foaming to a second foaming in a second moulding chamber filled with CO2 at a second temperature in the range of 20° C. below Tm to 5° C. below Tm and under a second pressure of 15-20 MPa for 30-3600 min to obtain the dielectric material, wherein the primary foaming comprises specific steps of: foaming a foaming material sphere with a diameter of 20-800 mm in a first moulding chamber filled with CO2 at a first temperature in the range of 80° C. below Tm to 20° C. below Tm and under a first pressure of 15-20 MPa to obtain the foamed sphere. Further provided is a dielectric material manufactured by the method above.

IPC Classes  ?

• C08J 9/12 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent

Abstract

Disclosed are a fluidized bed separation method and device for methanol-to-olefins quenched water. The method may subject quenched water to liquid-solid separation via a micro-cyclone separator. The method may also subject clear liquid from the micro-cyclone separator to a secondary separation via a fluidized bed separator, then sending the same to an olefin separation device, then recovering some waste heat of the quenched water, and then returning the same to a quenching tower after performing heat exchange. The method may also regenerate a separation medium by reversely feeding stripping tower purified water or quenched water, so as to release catalyst particles absorbed by the separation medium. The method may also send a catalyst slurry concentrated by the micro-cyclone separator and the fluidized bed separator to a filter-press unit for filter-press dehydration, so as to recover a catalyst.

IPC Classes  ?

• C02F 9/00 - Multistage treatment of water, waste water or sewage
• B01D 47/00 - Separating dispersed particles from gases, air or vapours by liquid as separating agent

Abstract

The present disclosure relates to a deep purification device and method for methanol-to-olefin washing water. Provided is a deep purification device for methanol-to-olefin washing water, comprising: a quench tower (1-1), a water washing tower (1-2) connected to an outlet at the top of the quench tower (1-1), a boiling bed separator (1-3) having the top thereof connected to the bottom of the water washing tower (1-2), a fiber coalescer (1-4) connected to the bottom of the boiling bed separator (1-3), and a buffer settling tank (1-5) connected to the sidewall of the boiling bed separator (1-3) at a position near the top. Further provided is a deep purification method for methanol-to-olefin washing water.

IPC Classes  ?

• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• B01D 17/04 - Breaking emulsions
• C02F 1/40 - Devices for separating or removing fatty or oily substances or similar floating material

Abstract

Provided is the use of a series of pteridinones and/or a pharmaceutically acceptable salt and a prodrug thereof as a non-canonical EGFR mutant inhibitor. Specifically, the present invention relates to the use of a series of compounds as represented by formula I and a pharmaceutical composition containing the series of compounds as represented by formula I in the preparation of a drug for treating a disease containing EGFR 20insX mutation, EGFR G719X mutation and ERBB2 mutation. Provided is the use of a series of pteridinones and/or a pharmaceutically acceptable salt and a prodrug thereof as a non-canonical EGFR mutant inhibitor. Specifically, the present invention relates to the use of a series of compounds as represented by formula I and a pharmaceutical composition containing the series of compounds as represented by formula I in the preparation of a drug for treating a disease containing EGFR 20insX mutation, EGFR G719X mutation and ERBB2 mutation.

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Abstract

Disclosed in the present invention are a pyruvic acid optical probe, a preparation method therefor, and an application thereof. One aspect of the present invention is the disclosure of an optical probe, which includes a pyruvic acid-sensitive polypeptide and an optically active polypeptide, wherein the optically active polypeptide is located within the sequence of the pyruvic acid-sensitive polypeptide. The present invention also discloses a preparation method for the probe and an application of said probe in pyruvic acid measurement.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• C07K 14/245 - Escherichia (G)

Abstract

A mesoporous silica nanoparticle controlled release system, a preparation method thereof and an application thereof, and specifically provides a mesoporous silica nanomaterial that can be used for controlled release is disclosed. The mesoporous silica nanomaterial that can be used for controlled release comprises a mesoporous silica nanoparticle functionalized by means of a polyhydroxy compound and a nanoparticle plugging agent functionalized by means of a phenylboronic acid compound. When substrate concentration is relatively low, the nanomaterial achieves “zero early release”; when substrate concentration is relatively high, mesoporous pores blocked by the plugging agent are opened and active ingredients are released. The nanomaterial can be loaded into microneedles and microneedle array patches used to treat diabetes or to control blood sugar levels in patients.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 38/28 - Insulins

Abstract

A low-temperature liquid hydrogen environment material fatigue performance test system, which relates to the technical field of mechanical property test platforms, and mainly comprises a jacket cover (4). A hydrogen sensor (3) is provided at the top in the jacket cover (4); a rack (7), a liquid hydrogen tank (5) and a liquid nitrogen tank (6) are provided in the jacket cover (4); a loading mechanism (1) and a liquid hydrogen bearing mechanism (2) are provided on the rack (7), the loading mechanism (1) is connected to the rack (7), and the bottom of the loading mechanism (1) extends into the liquid hydrogen bearing mechanism (2); the liquid hydrogen tank (5) and the liquid nitrogen tank (6) both communicate with the liquid hydrogen bearing mechanism (2); and the loading mechanism (1) is used to provide tension or pressure to a sample (30). The liquid hydrogen bearing mechanism (2) is provided with a cooling channel located around a sealing gasket (24), the cooling channel communicates with a thermostat (8), and the temperature around the sealing gasket (24) is maintained by means of the thermostat (8), so as to prevent the sealing gasket (24) from failing due to the temperature being too low, thereby preventing hydrogen leakage. The jacket cover (4) is used to ensure test safety when hydrogen gas leaks, the hydrogen sensor (3) is used to monitor whether hydrogen gas leaks, and, if leakage occurs in the test, the gas in the jacket cover (4) may be discharged to a specific environment.

IPC Classes  ?

• G01N 3/18 - Performing tests at high or low temperatures
• G01N 3/32 - Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces

Abstract

The present invention relates to the technical field of coatings, and provides a thermal barrier coating and a preparation method therefor. The thermal barrier coating provided in the present invention is of a double-layer structure, and comprises an intermediate layer attached to a surface of a metal bonding layer and a top layer; the intermediate layer is formed by atmospheric plasma spray of YSZ porous microspheres, and the top layer is formed by atmospheric plasma spray of Yb-Gd co-doped YSZ porous microspheres; the intermediate layer is in contact with the surface of the metal bonding layer, and the top layer is directly exposed to a high-temperature gas environment. The thermal barrier coating provided in the present invention has low thermal conductivity, excellent sintering resistance, and long service life.

IPC Classes  ?

• C23C 4/11 - Oxides
• C23C 4/134 - Plasma spraying
• B22F 1/054 - Nanosized particles
• B22F 1/065 - Spherical particles
• B22F 3/11 - Making porous workpieces or articles
• B22F 9/02 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using physical processes

Abstract

An ultrahigh-temperature wind tunnel erosion testing system is provided, including a fuel system (1), an erosion system (2), an erosion spray gun (3), a test piece fixture (5) and a testing device; the erosion spray gun (3) is connected with the fuel system (1) and the erosion system (2) respectively; the erosion spray gun (3) is arranged on a lifting and rotating mechanism (4); the test piece fixture (5) is arranged on one side of the lifting and rotating mechanism (4) and is opposite to a nozzle of the erosion spray gun (3); and the testing device is connected with the test piece fixture (5). The plurality of groups of test pieces are circlewise arranged around the lifting and rotating mechanism (4).

IPC Classes  ?

• G01M 9/04 - Wind tunnels Details
• G01N 3/56 - Investigating resistance to wear or abrasion

Abstract

Provided is an arginine fluorescent probe, comprising a polypeptide B that responds to arginine and a fluorescent protein A that expresses arginine; the fluorescent protein A is inserted into the polypeptide B, B is divided into an upper structural part and a lower structural part, B1 and B2, and a probe structure represented by the formula B1-A-B2 is formed; optimized mutants are likewise obtained by truncation and site-directed mutagenesis at different positions, and specific binding of the polypeptide B and arginine leads to a change in the fluorescence signal of the fluorescent protein A; and the polypeptide B is an arginine binding protein or a mutant thereof. The arginine fluorescent probe provided by the present invention has a relatively small protein molecular weight, is easy to express, experiences large dynamic changes in fluorescence, has good specificity, can be expressed, by means of genetic manipulation, in different subcellular organelles of cells, and can be used for the high-throughput, quantitative detection of arginine inside and outside of cells.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof

Abstract

Disclosed is a tryptophan optical probe, a preparation method therefor and the use thereof. Disclosed is an optical probe, comprising a tryptophan-sensitive polypeptide or a functional variant thereof and an optically active polypeptide or a functional variant thereof, wherein the optically active polypeptide or the functional variant thereof is located in the sequence of the tryptophan-sensitive polypeptide or the functional variant thereof. Furthermore, disclosed are a method for preparing the above-mentioned probe and the use thereof in the detection of tryptophan.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

Disclosed are an aza-phenothiazine derivative and use thereof in preparing a drug for the treatment of endometrial cancer. The structure of the derivative is represented by formula I, and the definitions of substituents are described in the description and claims. The aza-phenothiazine derivative of the present invention has an inhibitory effect on the proliferation, clonogenicity, and invasion ability of Ishikawa and KLE endometrial cancer cells, and can induce apoptosis. Therefore, the aza-phenothiazine derivative provided by the present invention is expected to be used for preparing a drug for the treatment and/or prevention of type I and type II endometrial cancer.

IPC Classes  ?

• A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
• A61P 35/00 - Antineoplastic agents
• C07D 513/04 - Ortho-condensed systems

Abstract

A low-carbon production method and production system for cement clinker. The production method comprises calcining a metal oxide, which is obtained by converting carbonate in a raw material by means of a methane dry reforming reaction, to form cement clinker, and meanwhile obtaining synthesis gas. The production system uses a reformer furnace for methane dry reforming of carbonate to replace a carbonate decomposition furnace in an existing cement production system.

IPC Classes  ?

• C04B 7/36 - Manufacture of hydraulic cements in general
• C01B 3/36 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using oxygen or mixtures containing oxygen as gasifying agents
• F27B 19/04 - Combinations of different kinds of furnaces that are not all covered by any single one of main groups arranged for associated working

Abstract

Provided in the present invention are a physically mixed catalyst for the epoxidation of propylene using hydrogen and oxygen, and a preparation method therefor. The catalyst is prepared by loading gold on a carrier which contains no titanium, has a large specific surface area and interacts strongly with gold, and then physically mixing same with a titanium-containing material at any ratio. Such a catalyst avoids problems such as an improvement in the dispersity and thermal stability of gold particles not being facilitated due to the relatively small specific surface area of a carrier where gold is loaded on an uncalcined titanium silicon molecular sieve having excellent properties and having micropores blocked by a template agent, and the interaction between gold and the carrier being relatively weak; and the catalyst makes a breakthrough in the limitation where Au on a traditional loaded Au-Ti bifunctional catalyst needs to be deposited near Ti, and has important significance for the development of a high-performance and high-stability catalyst required by the industry.

IPC Classes  ?

• B01J 29/89 - Silicates, aluminosilicates or borosilicates of titanium, zirconium or hafnium
• B01J 37/08 - Heat treatment
• B01J 37/04 - Mixing
• C07D 301/10 - Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with air or molecular oxygen in the gaseous phase with catalysts containing silver or gold
• C07D 303/04 - Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Abstract

The present invention provides a global energy consumption optimization method and device for an industrial production process and a computer readable storage medium. The global energy consumption optimization method comprises the following steps: determining a plurality of production units involved in energy consumption in an industrial production process; determining the production units as energy consumption nodes, and determining energy consumption models of the production units; determining production units involved in a constraint as constraint nodes, and determining constraint models of the production units involved in the constraint; and performing, by means of transmission of energy consumption information and constraint information between the nodes, distributed optimization of the production units so as to realize the global optimization of the total energy consumption of the industrial production process. By executing the steps, the global energy consumption optimization method can simplify the structure of an optimization model, reduce the modeling difficulty of optimization, and improve the optimization efficiency and real-time performance of the industrial production process.

IPC Classes  ?

• G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling

Abstract

The application relates to a robot machining system and control method for ultrasonic surface rolling process of an aircraft engine blade. The robot machining system includes: a robot, to which an ultrasonic surface rolling process device is fixed, the robot drives the ultrasonic surface rolling process device to move; a base provided with a spindle turntable and a three-dimensional mobile lifting device, the spindle turntable being provided with a rotatable blade clamp, and a flexible follow-up support head being fixed to the three-dimensional mobile lifting device; and a control system, which is in electrical connection or communication connection with the robot, the spindle turntable and the three-dimensional mobile lifting device, respectively. According to the application, the robot assists in clamping ultrasonic rolling device and cooperates with the three-dimensional mobile lifting device and the flexible follow-up support head, such that the accurate ultrasonic surface rolling process of blade is realized.

IPC Classes  ?

• C21D 7/04 - Modifying the physical properties of iron or steel by deformation by cold working of the surface
• C22F 3/00 - Changing the physical structure of non-ferrous metals or alloys by special physical methods, e.g. treatment with neutrons

Abstract

The present invention provides a multi-objective optimization method and apparatus for a fluid catalytic cracking process, and a computer readable storage medium. The multi-objective optimization method comprises the following steps: determining a plurality of optimization objectives, a plurality of process decision variables corresponding to the plurality of optimization objectives, and the constraint scope of each process decision variable; determining an objective function according to the plurality of optimization objectives and the plurality of process decision variables; improving an SPEA2 of a filial generation evolution process by means of a path-based reproduction operator, and adjusting the values of the process decision variables within the constraint scopes to determine operation data of the objective function with respect to the process decision variables; determining an optimization objective value of each optimization objective according to each piece of the operation data; and according to the optimal optimization objective value solution set, determining guidance values of the plurality of process decision variables corresponding to the plurality of optimization objectives.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation
• C10G 11/00 - Catalytic cracking, in the absence of hydrogen, of hydrocarbon oils
• G06F 111/06 - Multi-objective optimisation, e.g. Pareto optimisation using simulated annealing [SA], ant colony algorithms or genetic algorithms [GA]

Abstract

The present application relates to the field of assembly of biomacromolecules, and discloses a preparation method for a collagen material stripped from an electrode, and a use of the collagen material. The preparation method for the collagen material stripped from the electrode comprises the following steps: electrochemically depositing a collagen solution containing hydrogen peroxide and/or acetic acid, and then obtaining a collagen material on an electrode. The method can directly obtain the collagen material on the surface of the electrode.

IPC Classes  ?

• A61L 27/24 - Collagen
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/04 - Metals or alloys
• A61L 27/32 - Phosphorus-containing materials, e.g. apatite
• C25D 1/00 - Electroforming
• C25D 9/02 - Electrolytic coating other than with metals with organic materials
• C25B 15/02 - Process control or regulation
• A61F 13/00 - Bandages or dressingsAbsorbent pads
• C25B 3/09 - Nitrogen containing compounds

Abstract

13C.

IPC Classes  ?

• G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance

Abstract

A big data-based method for identifying and optimizing oil refining process modes, belonging to the technical field of oil refining process monitoring. The method comprises the following steps: preprocessing historical data acquired during an oil refining process to obtain standardized data; processing the standardized data using a principal component analysis method, and using a score matrix to establish a model and draw a confidence ellipse; calculating a score matrix of new samples collected in real time, and projecting the samples to the confidence ellipse; when the samples projected into the ellipse are normal points, said points can be added to the historical data to establish a new model so as to implement self-adaptive updating of the model; when the samples projected to the outside of the ellipse are abnormal points, fault tracing can be carried out according to a fault contribution rate; and further, on the basis of original variables corresponding to the points in the confidence ellipse, using an improved path optimization algorithm to solve an operation variable adjustment mode and a path.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation

Abstract

The present invention relates to the technical field of petrochemical production, in particular to a data-driven mixed crude oil cutting calculation analysis method and system. The method comprises the following steps: step S1, constructing a yield and property database for each mixed crude oil formulation by utilizing actual production data, processed by a single mixed crude oil formulation, of an atmospheric and vacuum distillation unit; step S2, by utilizing the actual processing data of all the mixed crude oil formulations, performing summarizing and calculating to obtain yield and property data of a single oil type, and constructing a second database; step S3, calculating similarity between a formulation of mixed crude oil to be analyzed and a formulation in a first database; and step S4, performing fusing with the yield and property data of the single oil type in the second database, and performing cutting calculation analysis on the mixed crude oil to be analyzed to obtain an analysis result. According to the present invention, the yield and the properties of different side line distillate oil of the atmospheric and vacuum distillation unit under different crude oil cutting points are predicted, the primary processing efficiency of the crude oil is improved, and a reference is provided for operation of a secondary processing device of the crude oil.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation

Abstract

Provided is a method for preparing γ-PGA coupled with an ATP regeneration enzyme and a poly(glutamic acid) synthetase, specifically a method for preparing a poly(glutamic acid) (γ-PGA) using glutamic acid or sodium glutamate as a substrate by means of an enzymic method, belonging to the technical field of biological engineering. The method comprises biological enzymes used in combination, or an expression vector or a cloning vector expressing the biological enzymes used in combination, or a transgenic cell line expressing the biological enzymes used in combination, or a genetically engineered bacterium expressing the biological enzymes used in combination, preferably, poly(glutamic acid) synthetase PgsB and polyphosphate kinase PPK used in combination.

IPC Classes  ?

• C12P 13/02 - Amides, e.g. chloramphenicol
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/54 - Transferases (2)
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli

Abstract

An optical probe, comprising a lactic acid-sensitive polypeptide or a functional variant thereof and an optically active polypeptide or a functional variant thereof; the optically active polypeptide or the functional variant thereof is located in the sequence of the lactic acid-sensitive polypeptide or the functional variant thereof. A preparation method for the described probe and an application thereof in the detection of lactic acid.

IPC Classes  ?

• C12N 15/62 - DNA sequences coding for fusion proteins
• C07K 14/245 - Escherichia (G)
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

An application of a novel thiazole derivative in the treatment of an RNA virus infection and the preparation of a drug for treating an RNA virus infection. Specifically, the present invention relates to a use of a compound represented by the following formula I and a pharmaceutical composition containing a compound represented by the following formula I in treating an RNA virus infection and preparing a drug for treating a coronavirus infection. An application of a novel thiazole derivative in the treatment of an RNA virus infection and the preparation of a drug for treating an RNA virus infection. Specifically, the present invention relates to a use of a compound represented by the following formula I and a pharmaceutical composition containing a compound represented by the following formula I in treating an RNA virus infection and preparing a drug for treating a coronavirus infection.

IPC Classes  ?

• A61K 31/426 - 1,3-Thiazoles
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine

Abstract

Disclosed is a thin-walled metal mechanical property changing method, comprising: step 1, fitting and assembling a workpiece and a workpiece substrate, and fixing the workpiece and the workpiece substrate on a precise movable platform; step 2, performing light spot path planning according to the surface topography of the workpiece; and step 3, using laser of which the power density is on the order of GW/cm2, the spot diameter is on the order of μm, and the pulse width is in the femtosecond scale to impact the surface of the workpiece, using explosive shock waves to modify the interior of the workpiece, and controlling the light spot to move along the light spot path, so that the light spot coverage rate of the surface of the workpiece is 300% or more. As the femtosecond laser is used to modify a thin-walled metal, the total amount of generated plasma is less, the peak pressure of the shock waves is higher, the acting force time is shorter, and the generated impact force, i.e., the impact momentum, is smaller, so that the thin-walled metal material generates dynamic yield response to generate microstructure change and a pre-stress field, but bending deformation is not prone to occurring; the purpose of changing mechanical properties of a thin-walled metal part is achieved.

IPC Classes  ?

• C21D 10/00 - Modifying the physical properties by methods other than heat treatment or deformation
• C22F 3/00 - Changing the physical structure of non-ferrous metals or alloys by special physical methods, e.g. treatment with neutrons

Abstract

The present invention relates to a digital twin-based pressure vessel safety evaluation and risk warning method, comprising the steps of: S1, determining a damage mode of a pressure vessel; S2, designing an overall scheme for pressure vessel safety evaluation and risk warning; and S3, simplifying a physical model of a pressure vessel on the basis of the designed overall scheme, and establishing a simplified physical model; S4, obtaining a load working condition parameter of the pressure vessel during actual service; S5, determining a material performance parameter of a part of the pressure vessel; S6, establishing a pressure vessel safety evaluation and risk warning digital twin model; S7, obtaining a full-field damage distribution cloud map of the part of the pressure vessel; and S8, comparing the full-field damage distribution cloud map with a strength requirement of the material of the part of the pressure vessel; if the strength requirement is satisfied, performing safety evaluation again at a next time node according to a subsequent requirement of a user, and if the strength requirement is not satisfied, outputting a pressure vessel risk warning.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation
• G06F 30/17 - Mechanical parametric or variational design
• G06F 119/04 - Ageing analysis or optimisation against ageing
• G06F 119/14 - Force analysis or force optimisation, e.g. static or dynamic forces

Abstract

Disclosed is a supercritical carbon dioxide assisted periodic devolatilization process. The process comprises a plurality of pressure cycle periods and uses carbon dioxide as a supercritical medium; the pressure is firstly increased and then reduced during the pressure cycle periods, so that the carbon dioxide is converted between a supercritical state and a gaseous state to realize polymer devolatilization. In order to implement devolatilization of a heat-sensitive polymer, the present invention makes use of the principles that the solubility of volatiles in supercritical CO2 is greater than the solubility thereof in the polymer and that periodic pressure is used to promote defoaming; the present invention can efficiently devolatilize at a low temperature with a short devolatilization time, can enable the discharge of materials while devolatilizing, reduces the content of volatiles in the devolatilized polymer to below 50ppm, and is highly efficient.

IPC Classes  ?

• C08F 6/00 - Post-polymerisation treatments
• C08F 120/14 - Methyl esters
• C08F 114/06 - Vinyl chloride
• C08F 236/06 - Butadiene
• C08F 236/08 - Isoprene
• B01D 1/14 - Evaporating with heated gases or vapours in contact with the liquid