A tissue treatment device comprises an upper housing (12) for receiving a container (20) with a treatment medium; an actuatable valve structure (16) to which the container can connect to dispense the treatment medium, the valve structure connected to the upper housing and comprising a channel (24) and an orifice (26) at an end of the channel; and a lower housing (14) extending from the upper housing to a distal end (28), the lower housing comprising an opening (32) at the distal end to receive tissue. The channel and/or lower housing is configured to direct treatment medium toward a side of tissue extending through the opening into the housing.
A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
B05B 7/04 - Spray pistolsApparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
B05B 12/00 - Arrangements for controlling deliveryArrangements for controlling the spray area
B05B 12/20 - Masking elements, i.e. elements defining uncoated areas on an object to be coated
B65D 83/30 - Nozzles, nozzle fittings or accessories specially adapted therefor for guiding the flow of the dispensed content, e.g. funnels or hoods
The invention relates to an aqueous vitamin B12 formulation for intranasal administration, comprising: · 3-100 mg/mL of a vitamin B12 component selected from hydroxocobalamin, cyanocobalamin, adenosylcobalamin, methylcobalamin, pharmaceutically acceptable salts of these cobalamins and combinations thereof · 30-300 mg/mL of sorbitol; wherein the vitamin B12 component and sorbitol are present in a weight ratio of vitamin B12 component : sorbitol of at least 0.2 and wherein the formulation has a pH in the range of 3.0 to 5.5.
The invention relates to a composition for use in the treatment of symptoms of herpes labialis in a human subject, wherein the treatment comprises topical administration to the skin of said human subject of a composition containing hinokitiol and 0.1-3 wt.% of water-soluble zinc salt. The invention also provides a topical formulation in the form of an emulsion, said formulation comprising: 15-70 wt.% of water; 10-50 wt.% of hydrophobic carrier selected from wax, petroleum jelly, paraffin, triglycerides and combinations thereof; 0.01-1 wt.% of hinokitiol; and 0.1-3 wt.% of water-soluble zinc salt.
The present invention relates to a dispensing system for spraying a liquid/gas mixture, the system including a dispenser and a holder in which the dispenser is held, the dispenser including a container that is adapted for holding therein a liquid phase and a gas phase that is at a pressure of 2 bar or greater and is in direct contact with the liquid phase. The dispensing system may be used in a first orientation and a second orientation, wherein the ratio of liquid to gas in the sprayed mixture is different depending on the orientation of the system during spraying.
B65D 83/36 - Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant allowing operation in any orientation
a) at its distal end. A porous material (16) is provided between the distal end (21) of the nozzle (20), at least between the open end of the nozzle and the skin contacting surface of the spacer.
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
Provided herein is a method of treating an infectious disease by administering to a patient a pharmaceutical formulation dissolved in aqueous medium having at least one free fatty acid, or a derivative and/or a pharmaceutically acceptable salt of the same, where the free fatty acid has from 6 to 16 carbon atoms, at least one carboxylic acid or a pharmaceutically acceptable salt of the same, and/or at least one carbohydrate or a pharmaceutically acceptable salt of the same. The carbohydrate may be selected from a hydrogenated carbohydrate, a monosaccharide, a disaccharide, a polysaccharide or a combination of the same. The antimicrobial composition provides enhanced anti-adhesion and/or disinfecting properties. The composition may be formulated into a drink, gel or spray, suitable for treating or preventing the first stage in pathogenesis.
A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
The present invention relates to a dispensing system for spraying a liquid/gas mixture, the system comprising a dispenser and a holder in which the dispenser is held, the dispenser comprising a container that is adapted for holding therein a liquid phase and a gas phase that is at a pressure of 2 bar or greater and is in direct contact with the liquid phase. The dispensing system may be used in a first orientation and a second orientation, wherein the ratio of liquid to gas in the sprayed mixture is different depending on the orientation of the system during spraying.
B65D 83/36 - Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant allowing operation in any orientation
An applicator for applying cryogenic fluid to a treatment area is described, the applicator comprising:a reservoir (12) configured to contain a cryogenic fluid comprising a gas phase (G) and a liquid phase (L). A nozzle (20) extends from a proximal end arranged in fluid communication with the reservoir (12) to an open distal end (21) for application of fluid to a treatment area. An actuatable valve is provided to selectively allow a flow of cryogenic fluid from the reservoir (12) through the distal end of the nozzle (20). A spacer (14) extends distally beyond the distal end (21) of the nozzle (20), the spacer (14) comprising a skin contacting surface (14a) at its distal end. A porous material (16) is provided between the distal end (21) of the nozzle (20), at least between the open end of the nozzle and the skin contacting surface of the spacer.
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body
9.
Dispensing system for use in cryogenic skin treatment
The invention relates to a dispensing system for use in cryogenic skin treatment that is capable of targeted delivery of a cryogen at a high rate, thereby achieving rapid freezing of targeted skin tissue. The dispensing system of the present invention uses a cryogen that contains dimethyl ether and is designed to deliver the cryogen in an accurate and very effective manner.
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
The present invention relates to a method for administering water soluble physiologically active substances, said method comprising intranasally administering to a subject an aqueous composition comprising 0.001-25 wt. % of one or more fully dissolved physiologically active substances, the physiologically active substances having a water solubility in demineralized water of at least 15 mg/mL at 20° C. of, 0.01-10 wt. % nicotinamide, and at least 60 wt. % water. The invention also relates to a kit comprising said composition and to the use of nicotinamide as an enhancer of intranasal absorption of a physiologically active substance from an aqueous solution, wherein the aqueous solution further comprises 0.01-10 wt. % nicotinamide.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
A61K 31/4188 - 1,3-Diazoles condensed with heterocyclic ring systems, e.g. biotin, sorbinil
The invention relates to a dispensing system for use in cryogenic skin treatment that is capable of targeted delivery of a cryogen at a high rate, thereby achieving rapid freezing of targeted skin tissue. The dispensing system of the present invention uses a cryogen that contains dimethyl ether and is designed to deliver the cryogen in an accurate and very effective manner.
A61M 11/02 - Sprayers or atomisers specially adapted for therapeutic purposes operated by air pressure applied to the liquid to be sprayed or atomised
B05B 1/16 - Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with multiple outlet openingsNozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with strainers in or outside the outlet opening having selectively-effective outlets
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
12.
INTRANASAL ADMINISTRATION OF PHYSIOLOGICALLY ACTIVE SUBSTANCES
The present invention relates to a method for administering water soluble physiologically active substances, said method comprising intranasally administering to a subject an aqueous composition comprising 0.001-25 wt.% of one or more fully dissolved physiologically active substances, the physiologically active substances having a water solubility in demineralized water of at least 15 mg/mL at 20°C of, 0.01-10 wt.% nicotinamide, and at least 60 wt.% water. The invention also relates to a kit comprising said composition and to the use of nicotinamide as an enhancer of intranasal absorption of a physiologically active substance from an aqueous solution, wherein the aqueous solution further comprises 0.01-10 wt.% nicotinamide.
The present invention relates to a nebulizer, such as a spray can, for the topical application of a liquid and/or solid to a surface. The nebulizer is characterized by a valve comprising a mixing chamber designed for forming a colloidal mixture comprising a dispersed phase consisting of a liquid and/or a solid substance and a continuous phase consisting of a propellant gas before delivering the colloidal mixture to the nozzle. The invention also relates to a method for the topical cooling of the skin of a person or animal. In addition, the invention relates to various other uses of the device.
A61M 11/02 - Sprayers or atomisers specially adapted for therapeutic purposes operated by air pressure applied to the liquid to be sprayed or atomised
B05B 1/28 - Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with integral means for shielding the discharged liquid or other fluent material, e.g. to limit area of sprayNozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with integral means for catching drips or collecting surplus liquid or other fluent material
B65D 83/44 - Valves specially adapted for the discharge of contentsRegulating devices
B05B 1/16 - Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with multiple outlet openingsNozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with strainers in or outside the outlet opening having selectively-effective outlets
B05B 7/24 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
B65D 83/30 - Nozzles, nozzle fittings or accessories specially adapted therefor for guiding the flow of the dispensed content, e.g. funnels or hoods
B65D 83/36 - Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant allowing operation in any orientation
B65D 83/14 - Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
B65D 83/56 - Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant with arrangements for interruption of dispensing when the container is inverted
A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
B65D 83/48 - Lift valves, e.g. operated by push action
B05B 7/04 - Spray pistolsApparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
14.
NEBULIZER AND SPACER FOR THE TOPICAL APPLICATION OF A LIQUID AND/OR SOLID TO A SURFACE
The present invention relates to a nebulizer, such as a spray can, for the topical application of a liquid and/or solid to a surface. The nebulizer is characterized by a valve comprising a mixing chamber designed for forming a colloidal mixture comprising a dispersed phase consisting of a liquid and/or a solid substance and a continuous phase consisting of a propellant gas before delivering the colloidal mixture to the nozzle. The invention also relates to a method for the topical cooling of the skin of a person or animal. In addition, the invention relates to various other uses of the device.
The present invention relates to a composition for delivering components topically to mammal nails having enhanced nail penetration properties comprising: a water-miscible organic solvent present in an amount of more than 50% by weight of the total weight of the composition, a hydrophilic solvent present in an amount of less than 30% by weight of the total weight of the composition and a terpene and/or aetheric oil, wherein the total amount of terpene and aetheric oil is less than 20% by weight of the total weight of the composition. The present invention further relates to the use of the composition for the treatment of a nail disease, including nail infections preferably onychomycosis and a device comprising the composition for the application of the composition to a to be treated area.
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
The present invention relates to an antimicrobial composition comprising at least one free fatty acid or a derivative and/or a pharmaceutically acceptable salt thereof, wherein the free fatty acid is selected from a free fatty acid having from 6 to 16 carbon atoms, at least one carboxylic acid or a pharmaceutically acceptable salt thereof and/or at least one carbohydrate or a pharmaceutically acceptable salt thereof, wherein the carbohydrate is selected from a hydrogenated carbohydrate, a monosaccharide, a disaccharide, a polysaccharide and combinations thereof. The antimicrobial composition of the present inventions provides enhanced anti-adhesion and /or disinfecting properties. The composition of the present invention can be formulated into a drink, gel or spray suitable for treating or preventing the first stage in pathogenesis.
A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
05 - Pharmaceutical, veterinary and sanitary products
08 - Hand tools and implements
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceutical, veterinary and sanitary preparations, namely pharmaceutical preparations for dermatological use, namely for clinical treatment and prevention of external distensions of the skin being warts; hand tools and hand-operated implements, namely devices for the treatment and prevention of warts and other skin conditions, namely age spots; surgical and medical apparatus and instruments for the treatment of the skin, namely medical instruments for the treatment and prevention of warts and other skin conditions, namely age spots
18.
DISPENSING SYSTEM FOR USE IN CRYOGENIC SKIN TREATMENT
The invention relates to a dispensing system for use in cryogenic skin treatment that is capable of targeted delivery of a cryogen at a high rate, thereby achieving rapid freezing of targeted skin tissue. The dispensing system of the present invention uses a cryogen that contains dimethyl ether and is designed to deliver the cryogen in an accurate and very effective manner.
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61M 11/02 - Sprayers or atomisers specially adapted for therapeutic purposes operated by air pressure applied to the liquid to be sprayed or atomised
B05B 1/16 - Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with multiple outlet openingsNozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with strainers in or outside the outlet opening having selectively-effective outlets
19.
INTRANASAL ADMINISTRATION OF PHYSIOLOGICALLY ACTIVE SUBSTANCES
The present invention relates to a method for administering water soluble physiologically active substances, said method comprising intranasally administering to a subject an aqueous composition comprising 0.001-25 wt.% of one or more fully dissolved physiologically active substances, the physiologically active substances having a water solubility in demineralized water of at least 15 mg/mL at 20°C of, 0.01-10 wt.% nicotinamide, and at least 60 wt.% water. The invention also relates to a kit comprising said composition and to the use of nicotinamide as an enhancer of intranasal absorption of a physiologically active substance from an aqueous solution, wherein the aqueous solution further comprises 0.01-10 wt.% nicotinamide.
