Abstract

The invention relates to a coating composition in the form of a non-aqueous transparent dispersion, comprising a reactive diluent, polyurethane (meth)acrylate particles, which can be obtained by reacting a polyisocyanate with a polyol and a nucleophilically functionalized (meth)acrylic acid ester in the reactive diluent in order to form polyurethane (meth)acrylate particles having a mean diameter of less than 40 nm, and an initiator. Corresponding coating compositions are distinguished by especially favorable properties in particular with regard to the adhesive strength, hardness, and microscratch resistance of said coating compositions after the curing of said coating compositions and therefore are superior to conventionally available coating product without nanoparticulate polyurethane (meth)acrylate particles in many cases.

IPC Classes  ?

• C08G 18/48 - Polyethers
• C08G 18/66 - Compounds of groups , , or
• C08G 18/67 - Unsaturated compounds having active hydrogen
• C08G 18/75 - Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic
• C08G 18/08 - Processes
• C09D 175/16 - Polyurethanes having carbon-to-carbon unsaturated bonds having terminal carbon-to-carbon unsaturated bonds
• C08G 18/32 - Polyhydroxy compoundsPolyaminesHydroxy amines

Abstract

The present invention relates to prodrug derivatives of pentamidine, their use in the treatment and/or prophylaxis of diseases such as tumor diseases, as well as leishmaniasis, trypanosomiasis, pneumocystis carinii pneumonia (PcP), and malaria.

IPC Classes  ?

• C07C 259/18 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxyamidine groups bound to carbon atoms of six-membered aromatic rings
• A61K 31/225 - Polycarboxylic acids
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine

Abstract

The invention relates to a method for improving the bioavailability of pharmaceutical substances and for allowing the pharmaceutical substances to permeate the blood-brain barrier, the pharmaceutical substances having at least one or more amidine, guanidine, N-hydroxyamidine (amidoxime) or N-hydroxyguanidine functions. The invention also relates to medicaments containing the correspondingly modified pharmaceutical substances.

IPC Classes  ?

• C07C 251/66 - Oximes having oxygen atoms of oxyimino groups esterified by carboxylic acids with the esterifying carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/222 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine

Abstract

The invention relates to a high-frequency lamp in which high-frequency energy is coupled into a lamp body. Corresponding high-frequency lamps are known from the prior art. The plasma generated by known high-frequency lamps is comparatively unstable, however. Furthermore, the ionization chamber partly accumulates a comparatively high degree of dirt. The aim of the invention is to reduce this problem. This is achieved in that an antenna wire element (13, 14) for coupling in the high-frequency energy is arranged at least partly within a wall of the lamp body (11) without passing through said wall.

IPC Classes  ?

• H01J 65/04 - Lamps in which a gas filling is excited to luminesce by an external electromagnetic field or by external corpuscular radiation, e.g. for indicating

Abstract

The invention relates to an HF lamp. Such HF lamps comprise a lamp body (10), an HF control electrode (17) for feeding in HF energy, and an oscillator for generating the HF energy. However, known HF lamps can be brought to uniform temperatures only with difficulty and therefore do not have an optimal efficiency. Thus, the problem addressed by the invention is that of proposing an HF lamp that has an improved efficiency. The problem is substantially solved in that a dielectric waveguide (12) is provided, which extends over large regions, i.e. at least a third of the maximum diameter of the lamp body, within the lamp body (10).

IPC Classes  ?

• H01J 65/04 - Lamps in which a gas filling is excited to luminesce by an external electromagnetic field or by external corpuscular radiation, e.g. for indicating

Abstract

The invention relates to a method for producing a coating of an anode of a lithium-ion battery by means of an HF powder plasma spraying process. The method has the steps of (i) HF-plasma spraying a substrate in a recipient with carbon nanopowder which is supplied in a deagglomerated and/or deaggregated state and (ii) spraying the substrate with free silicon.

IPC Classes  ?

• H01M 4/04 - Processes of manufacture in general
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 4/66 - Selection of materials

Abstract

The invention relates to polymerizates that can be obtained by a) reacting at least one polyisocyanate with at least one polyol and optionally at least one radically curable monomer A with groups reactive toward isocyanate in at least one radically curable monomer B to form polyurethane particles having an average diameter of less than 40 nm, preferably less than 20 nm, and especially preferably less than 10 nm and an average number of radically curable functionalities in a range of 2 to 4, preferably 2 to 3, and b) emulsion polymerizing the product obtained under a). By means of the emulsion polymerization, larger cross-linked polyurethane/polymer hybrid dispersions are produced, in which the nanoparticles act as a connecting member between the polymer areas and the polyurethane components. This structure results in improved chemical resistance and significantly improved mechanical properties in comparison with traditional polyurethane dispersions, in which polyurethane nanoparticles are subsequently dispersed in polyacrylates, for example by means of an acetone method. Furthermore, the content of polyurethane in the polymer can be better controlled by means of this production method. The invention further relates to a method for producing such polymerizates and the use of such polymerizates as adhesives or coatings, in particular for textiles, or as paints, or for films and foils.

IPC Classes  ?

• C08G 18/66 - Compounds of groups , , or
• C08G 18/67 - Unsaturated compounds having active hydrogen
• C08G 18/73 - Polyisocyanates or polyisothiocyanates acyclic
• C08G 18/12 - Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step using two or more compounds having active hydrogen in the first polymerisation step
• C09D 175/16 - Polyurethanes having carbon-to-carbon unsaturated bonds having terminal carbon-to-carbon unsaturated bonds
• C09J 175/16 - Polyurethanes having carbon-to-carbon unsaturated bonds having terminal carbon-to-carbon unsaturated bonds
• C08G 18/69 - Polymers of conjugated dienes
• C08G 18/08 - Processes

Abstract

The invention relates to an HF system that comprises an HF device (5), particularly an HF lamp, as well an HF spark-plug or similar HF plasma application, and an HF signal-incoupling device (3) for operating said HF device (5). The HF system comprises an oscillator (7) for generating an HF signal to operate said HF device (5), and said system is characterised in that it comprises means (15) for generating a voltage signal (Uprop) that is proportional to the degree of adaptation of the HF device, on the basis of the HF signal generated by the oscillator (7) and a signal reflected by said HF device. Moreover, the system is characterised in that it comprises a device (27), preferably without a microprocessor, for generating a control signal (UA) for adapting the oscillator (7) output-frequency on the basis of the voltage signal (Uprop) which is proportional to the degree of adaptation of the HF device (5).

IPC Classes  ?

• H05B 41/24 - Circuit arrangements in which the lamp is fed by high-frequency AC

Abstract

The invention relates to a high-frequency lamp with a glass bulb and a device for supplying a high-frequency signal. High-frequency lamps known in the prior art either have been limited to a narrow selection of substances in the glass bulb or have relied on a heating process using a spiral-wound filament or the like. The aim of the invention is to provide an inexpensive and more efficient high-frequency lamp. This is to be achieved in particular in that the glass bulb is made, for example from window glass, so as to be heatable by the heat losses of the high-frequency signal in the glass bulb such that even metal halogenides for example can be evaporated without an additional heating process.

IPC Classes  ?

• H05B 41/24 - Circuit arrangements in which the lamp is fed by high-frequency AC
• H01J 65/04 - Lamps in which a gas filling is excited to luminesce by an external electromagnetic field or by external corpuscular radiation, e.g. for indicating

Abstract

The present invention relates to 5-amino-3-pheylamino-6-phenylpyrazolo[3,4-d] pyrimidine derivatives of the general formula (I) or pharmaceutically acceptable salts or prodrugs thereof, wherein at least one hydrogen atom is replaced in at least one of phenyl groups A and B by a substituent RH, which has a Hammett constant σp greater than 0.23. The present invention further relates to a method of manufacturing these. Corresponding compounds have been found to have surprisingly high activity against viruses, particularly rhinoviruses and picornaviruses. Moreover, the compounds are very well tolerated. For these reasons, the compounds are suited for the treatment of viral infections and as medications.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 31/12 - Antivirals

Abstract

The invention relates to prodrug derivatives of dabigatran, and to the use thereof for the treatment and/or prophylaxis of illnesses, in particular thrombotic illnesses, stroke, heart attack and/or atrial fibrillation and arrhythmia, and oncological illnesses of any pathogenesis.

IPC Classes  ?

• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to prodrug derivatives of dabigatran, their use in the treatment and/or prophylaxis of diseases, in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis.

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 9/10 - DispersionsEmulsions
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The invention relates to prodrug derivatives of pentamidine, to the use thereof for the treatment and/or prophylaxis of diseases, in particular tumours, leishmaniasis, trypanosomiasis, Pneumocystis carinii pneumonia (PcP), and malaria.

IPC Classes  ?

• A61K 31/222 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
• C07C 259/18 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxyamidine groups bound to carbon atoms of six-membered aromatic rings
• A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• A61P 33/06 - Antimalarials

Abstract

The invention relates to an exchanger device for transferring mass and/or energy between a first and second medium. The device comprises a chamber which has a first inlet and outlet of the first medium and through which the first medium can flow, and the chamber is equipped with at least one mass- and/or energy-permeable exchanger hollow fiber, preferably a plurality of mass- and/or energy-permeable exchanger hollow fibers, which is/are connected at one end to a second inlet and at the other end to a second outlet of the second medium, wherein the second medium can flow through the fiber(s) and the first medium can flow around the fiber(s). The chamber is equipped with at least one pump element by means of which the first medium can be displaced out of the chamber and sucked into the chamber in a pulsing manner. The pump element has an elastically deformable element and is connected to a third inlet of a third medium that is used as a driving medium, said pump element being expandable by the third medium.

IPC Classes  ?

• A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes

Abstract

The present invention relates to a process for producing a polycrystalline layer. This process comprises the steps of applying a layer sequence, comprising at least one amorphous starting layer provided with impurities, a metallic activator layer and a cleaning layer based on titanium or titanium oxide arranged between the starting layer and the activator layer for withdrawing the impurities from the starting layer, to a substrate; and carrying out a heat treatment after the layer sequence has been applied for forming a polycrystalline end layer.

IPC Classes  ?

• C23C 14/14 - Metallic material, boron or silicon
• C23C 14/58 - After-treatment

Abstract

The invention relates to a hollow fiber bundle (1) for accommodation in a mass transfer device, said hollow fiber bundle comprising a multitude of hollow fiber strands (10a, 10b, 10c) for heat transfer and/or mass transfer which are aligned essentially at least locally along a preferential direction and are arranged with respect to one another in relation to their local preferential directions such that at least one first group of hollow fiber strands points essentially in a first preferential direction (Vl), at least one second group of hollow fiber strands essentially in a second preferential direction (V2) and at least one third group of hollow fiber strands in essentially a third preferential direction (V3), said three preferential directions being independent of one another.

IPC Classes  ?

• B01D 63/02 - Hollow fibre modules
• B01D 63/04 - Hollow fibre modules comprising multiple hollow fibre assemblies
• A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes

Abstract

The invention relates to a method for producing a biocompatible and a biodegradable composite material usable as a medical product, wherein a) a hydrogel comprising at least one synthetic polymer and at least one natural polymer is provided, b) an electrical field is applied to the hydrogel, c) a structuring of the hydrogel is induced, particularly forming pores in the hydrogel, d) the hydrogel is subjected to a drying process, and e) the dried hydrogel is sterilized and cross-linked by chemical and/or physical means, forming the composite material. The invention further relates to a composite material obtainable by means of said method and particularly comprising pores and/or pore channels in which substances promoting cell growth, cell deposition, and/or cell adhesion can be introduced. A result thereof is an advantageous potential application of the composite material as a carrier for biological cells, particularly human, animal, or plant cells, and as a tissue replacement in the human or animal body.

IPC Classes  ?

• A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials

Abstract

The invention relates to a non-aqueous dispersion of organic polymer particles in a reactive diluent. Said non-aqueous dispersion can be obtained in that at least one monomer is polymerized in the reactive diluent, forming the organic polymer particles, wherein the reactive diluent does not participate in said polymerization due to the orthogonal reactivity thereof relative to the monomers, but comprises a functionality allowing later targeted polymerization. Depending on the organic polymer particles or reactive diluents used, the non-aqueous dispersion can be used in multifaceted applications having a wide range of application profiles. In order to produce said non-aqueous dispersion, polymerization of at least one monomer in a stirred tank reactor in the presence of a reactive diluent is particularly suitable, wherein the conversion is performed at a stirring speed of at least 2 m/s, wherein the ratio of the stirrer diameter to the vessel diameter is set to 0.3 – 0.80 and the distance from the stirrer to the vessel floor is set to 0.25 to 0.5 times the stirrer diameter. The invention provides multifaceted advantageous applications, particularly as an impact strength modifier, particularly in films, and as an adhesive, as casting resin, or as paint. A particularly advantageous application is producing a molded part or a semi-finished polymer product.

IPC Classes  ?

• C08G 18/08 - Processes
• C08G 18/67 - Unsaturated compounds having active hydrogen
• C08G 18/75 - Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic
• C09D 175/08 - Polyurethanes from polyethers
• C09J 175/16 - Polyurethanes having carbon-to-carbon unsaturated bonds having terminal carbon-to-carbon unsaturated bonds

Abstract

The invention relates to a prodrug comprising a partial structure having the general formula (I) or (II), where R1 and R2 are hydrogen, alkyl, or aryl radicals.

IPC Classes  ?

• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• C07C 257/10 - Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines

Abstract

The invention relates to a method for spectroscopic real-time detection of nucleic acid molecules, in particular polynucleotide sequences, in a PCR amplification (PCR=polymerase chain reaction), wherein the PCR amplification comprises preparing the initial substances required for producing a PCR solution in a buffer and the repeating PCR reaction steps of denaturing, primer hybridization and elongation, and wherein electromagnetic radiation is irradiated into the PCR solution during the PCR amplification at defined time points from a radiation source in the gigahertz or terahertz regime in order to detect at least the presence or absence of a polynucleotide sequence using a detector in a real-time detection.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

A lithium battery comprises an anode and a cathode structure which are separated from one another by a membrane structure. The membrane structure comprises a layer that only conducts lithium ions, said layer being characterized by the property of sufficient mechanical rigidity above the temperature of 150 °C to prevent a local short-circuit between the anode and the cathode structure.

IPC Classes  ?

• H01M 2/16 - Separators; Membranes; Diaphragms; Spacing elements characterised by the material
• H01M 10/05 - Accumulators with non-aqueous electrolyte

Abstract

What is described in a substrate that comprises a layer (2) that is largely transparent at least for radiation with a wavelength of 600 nm to 1200 nm at a layer temperature below a transition temperature and at a layer temperature above the transition temperature is nearly impermeable. The described substrate is characterized in that the layer (2) comprises a system of materials comprising a base material selected from the group Bi(RxOy), where R is a metal, said base material being doped with an additive from the group (Yz)MnO3, i.e. from the group of manganates.

IPC Classes  ?

• C09K 9/00 - Tenebrescent materials, i.e. materials for which the range of wavelengths for energy absorption is changed as a result of excitation by some form of energy
• H01L 31/04 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices

Abstract

A solar cell comprises a substrate made of a textile surface structure. The textile surface structure is made of transparent glass fiber threads and electrically conducting but non-transparent carbon fiber threads. The glass fiber threads serve as spacers and fillers for the carbon fiber threads so that closed interstices of sufficient transparency result between the carbon fiber threads, whereby the light can pass through the substrate. On both sides of the so formed substrate are semiconductor layers forming a blocking layer therebetween. One electrode is formed by the carbon fiber threads of the substrate.

IPC Classes  ?

• H01L 25/04 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices all the devices being of a type provided for in a single subclass of subclasses , , , , or , e.g. assemblies of rectifier diodes the devices not having separate containers
• H01L 31/0224 - Electrodes

Abstract

4-amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidine derivatives of general formula (I), pharmaceutically acceptable salts thereof, method for preparation of the aforesaid compounds and their use as antiviral agents.

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• C07D 487/00 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups
• C07D 487/04 - Ortho-condensed systems

Abstract

In a method for producing polycrystalline layers a sequence of layers is deposited on a substrate (1), the sequence of layers comprising an amorphous initial layer (4), a metallic activation layer (2) and an intermediate layer (3) disposed between the amorphous initial layer (4) and the activation layer (2). The intermediate layer (3) is produced on the basis of titanium. The sequence of layer is heat treated for producing a polycrystalline final layer at the location of the activation layer (2).

IPC Classes  ?

• H01L 21/20 - Deposition of semiconductor materials on a substrate, e.g. epitaxial growth

Abstract

The invention relates to an implantable reservoir body which, as and when required, makes available a working medium that serves at least to inflate an implantable unit. The invention is characterized in that an elastic hollow body is provided whose wall encloses a reservoir volume, in that an induction coil arrangement is provided inside the reservoir volume and/or in that an induction coil arrangement is connected to the wall of the hollow body, in that the induction coil arrangement is connected to a pump/electronics unit provided inside or outside the hollow body, and in that a fluid channel is provided which leads out of the hollow body and which is connected to the pump unit and/or directly to the implanted unit that is to be inflated.

IPC Classes  ?

• A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61F 2/02 - Prostheses implantable into the body

Abstract

The invention relates to a surface sensor (100, 200), comprising a frequency-selective surface with periodically arranged THz structures (1), in particular THz resonance structures (1), which are sensitive to THz radiation, a polarization axis (3) being associated to each structure. In order to improve remote field characteristics, the invention provides that a THz structure (1) is configured asymmetrically and a group of two or more THz structures (1) have essentially centrosymmetrically aligned polarization axes (3) for forming a unit cell.

IPC Classes  ?

• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light

Abstract

The invention relates to a method for improving bioavailability of pharmaceutical substances and for allowing said pharmaceutical substances to permeate the blood-brain barrier, said pharmaceutical substances having at least one or more amidine, guanidine,N-hydroxyamidine (ami-doxime) or N-hydroxyguanidine-functions. The invention also relates to medicaments containing correspondingly modified pharmaceutical substances.

IPC Classes  ?

• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
• A61P 9/12 - Antihypertensives
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61P 31/18 - Antivirals for RNA viruses for HIV
• A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to a method for improving bioavailability of pharmaceutical substances and for allowing said pharmaceutical substances to permeate the blood-brain barrier, said pharmaceutical substances having at least one or more amidine, guanidine, N-hydroxyamidine (amidoxime) or N-hydroxyguanidine-functions. The invention also relates to medicaments containing correspondingly modified pharmaceutical substances.

IPC Classes  ?

• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61P 35/00 - Antineoplastic agents
• A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• A61P 31/18 - Antivirals for RNA viruses for HIV
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 9/12 - Antihypertensives

Abstract

The invention relates to a method for improving the bioavailability of pharmaceutical substances and for allowing said pharmaceutical substances to permeate the blood-brain barrier, said pharmaceutical substances having at least one or more amidine, guanidine, N-hydroxyamidine (amidoxime) or N-hydroxyguanidine functions. The invention also relates to medicaments containing correspondingly modified pharmaceutical substances.

IPC Classes  ?

• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/401 - ProlineDerivatives thereof, e.g. captopril
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
• A61P 31/12 - Antivirals

Abstract

The invention relates to a novel design for constructing a high-frequency lamp (10) for low and high-pressure applications and a method for the operation thereof, particularly suitable for improving the characteristics with regard to efficiency, emission spectrum, cost, and long life, in that the use of an exciter unit is no longer necessary, even at very low high-frequency power, due to an impedance transformer (26) connected downstream from a power amplifier (20), because the application of as high a voltage as possible to an ionization chamber (16) is possible using the impedance transformation.

IPC Classes  ?

• H05B 41/24 - Circuit arrangements in which the lamp is fed by high-frequency AC
• H01J 65/04 - Lamps in which a gas filling is excited to luminesce by an external electromagnetic field or by external corpuscular radiation, e.g. for indicating

Abstract

A semiconductor component comprises a carrier and, on one side of the carrier, at least one semiconductor layer embodied in polycrystalline fashion. The polycrystalline semiconductor layer contains the crystallization seeds.

IPC Classes  ?

• H01L 21/20 - Deposition of semiconductor materials on a substrate, e.g. epitaxial growth
• H01L 21/208 - Deposition of semiconductor materials on a substrate, e.g. epitaxial growth using liquid deposition
• H01L 21/36 - Deposition of semiconductor materials on a substrate, e.g. epitaxial growth

Abstract

The invention relates to a device for transferring mass and/or exchanging energy between two media, particularly between blood and a gas/gas mixture. Said device comprises a chamber (2), through which the first medium flows and inside which at least one mass-permeable and/or energy-permeable hollow fiber (5), preferably a plurality of mass-permeable and/or energy-permeable hollow fibers (5), is/are arranged. The second medium can flow through said at least one hollow fiber (5) while the first medium can flow therearound. At least one pumping element (5) which allows the first medium to be displaced from the chamber (2) and/or to be sucked into the chamber (2) is disposed in the chamber (2) of the device.

IPC Classes  ?

• A61M 1/10 - Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
• A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
• A61M 1/26 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes which are moving

Abstract

The invention relates to novel antimicrobial agents that are based on ß-lactam derivatives and are produced by reacting previously known ß-lactam derivatives with polyphenol oxidase substrates under the influence of free radicals and by forming salts of any ß-lactam derivatives with polyhexamethylene biguanide hydrogen carbonate. Said novel compounds are suitable as an antibiotic.

IPC Classes  ?

• A61K 31/545 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61P 31/04 - Antibacterial agents

Abstract

The invention relates to a method for producing thin layers of metal-ceramic composite materials containing metallic nanoparticles. Said method can be used for coating a solar absorber with a cermet-based selectively absorbing surface layer that is very easy and inexpensive to produce in a reliable manner and has good spectral selectivity. In said method, one or more thin cermet layers are deposited on a substrate by immersing metallic substrates into a stabilized aqueous or organic suspension. The suspension is composed of alcoholic or aqueous solution in which ceramic nanopowders are dispersed and which contains the metallic portion of the cermet in the form of metal ions.

IPC Classes  ?

• F24J 2/48 - characterised by the absorber material
• C23C 24/00 - Coating starting from inorganic powder
• C23C 28/00 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and
• C23C 18/12 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
• C03C 17/36 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with at least two coatings having different compositions at least one coating being a metal

Abstract

The invention relates to the use of N,N'-dihydroxyamidine (I), N,N'-dihydroxyamidine ether (II), N,N'-dihydroxyamidine diether (III), N,N'-dihydroxyamidine ester (IV), N,N'-dihydroxyamidine diester (V) or 4-hydroxy-1,2,4-oxadiazoline (VI) of the formulae cited above, wherein R represents hydrogen, an alkyl and/or aryl radical, as a substitute for an amidine function of a medicament for improving the bioavailability of the medicament.

IPC Classes  ?

• C07C 259/12 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)

Abstract

The invention relates to a 4-Amino-3-aryl amino -6-arylpyrazolo[3,4-d] pyrimidine derivatives, method for their preparation and their use as antiviral agents. The object was to provide novel compounds which can be employed as agents for example for the treatment of picomavirus infections and which avoid problems of known medicaments, especially relating to resistance and intolerance. This object is achieved by compounds of the general formula I. (see formula I)

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 31/12 - Antivirals
• C07D 487/04 - Ortho-condensed systems

Abstract

The invention relates to 4-amino-3-arylamino-6-arylpyrazolo[3,4-d]-pyrimidine derivatives, method for their preparation and their use as antiviral agents. The object was to provide novel compounds which can be employed as agents for example for the treatment of picornavirus infections and which avoid problems of known medicaments, especially relating to resistance and intolerance. This object is achieved by compounds of the general formula I.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 31/12 - Antivirals

Abstract

Described is a solubilisate of a preservative containing an aliphatic and/or aromatic acid such as sorbic acid and/or benzoic acid that is free of stabilizing agents, as well as one or more emulsifiers with an HLB value between 9 and 18 with a concentration of about 50% and about 95% emulsifier with regard to the total quantity of the solubilisate, and a procedure for the production of such a solubilisate.

IPC Classes  ?

• A23L 3/3463 - Organic compounds; Microorganisms; Enzymes
• A23L 29/10 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing emulsifiers