Abstract

The present invention relates to a treatment of CCHFV infection, in particular CCFHV infection. Here, the inventors showed that antibody blocking LDL-R family at the surface of human cells could reduce CCHFV infection by 80%, such inhibition only occurred when blocking was performed prior to or at the time of infection though not at later time points. Furthermore, they found that incubation of viral particles with a soluble form of LDL-R could impair CCHFV infection. They found that ApoE antibodies could block CCHFV infectivity by up to 10-fold only when the viral particles were produced in cells that express ApoE. Thus, the present invention relates to an LDL-R family and/or an ApoE inhibitor for use in the prevention and/or the treatment of CCHFV infection in subjects in need thereof.

IPC Classes  ?

• A61K 31/4748 - QuinolinesIsoquinolines forming part of bridged ring systems
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The invention concerns new oncolytic viruses and their uses In particular, the invention is a viral particle for its use in the prevention and/or the treatment of a tumor, said viral particle comprising: an inactivated nucleic acid sequence encoding the native envelope glycoprotein of the IROV encoded by said IROV genome; and a nucleic acid sequence encoding a retroviral envelope glycoprotein or a fragment thereof having a native targeting capacity for said host cell surface protein.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12N 15/86 - Viral vectors
• A61P 35/00 - Antineoplastic agents
• A61K 35/766 - Rhabdovirus, e.g. vesicular stomatitis virus

Abstract

The invention relates to an oligo-initiator, to the process for synthesizing same and to the use thereof for producing water-soluble hybrid polymers. It also relates to a water-soluble hybrid polymer obtained according to a synthesis process comprising the functionalization of a biopolymer by reacting its functional groups with the functional groups of the oligo-initiator, allowing the extension of synthetic polymer chains, thus forming said water-soluble hybrid polymer. The invention also relates to the use of the water-soluble hybrid polymer in various fields of application.

IPC Classes  ?

• C08F 2/38 - Polymerisation using regulators, e.g. chain terminating agents
• C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
• C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule

Abstract

The invention concerns a method for fabricating an array of magnets (10), the method comprising: - a step of deposition of a coercivity changing element according to a pattern on a first material having a first coercivity value, the coercivity changing element being adapted to change the coercivity of the first material, and - a step of diffusion of the coercivity changing element into certain regions to form a magnetic layer (16) having first areas (A1) made of the first material and second areas (A2) having a second coercivity, made of a second material comprising the first material and the coercivity changing element.

IPC Classes  ?

• H01F 7/02 - Permanent magnets
• H01F 1/032 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
• H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets
• H01F 13/00 - Apparatus or processes for magnetising or demagnetising
• H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties
• H01F 41/18 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for applying magnetic films to substrates by cathode sputtering
• H01F 10/12 - Thin magnetic films, e.g. of one-domain structure characterised by magnetic layers characterised by the composition being metals or alloys

Abstract

The invention relates to a measurement system (1) and to the associated measurement method, the system comprising an FTIR spectrometer (2) comprising a tracker module (20), a protection device (3) comprising a casing (30) and a protection module (31) movable between a closed position (P0) and at least one open position (P1). For this purpose, the protection module (31) comprises a cover (310) that is rotatable about an axis (A1) parallel to the main extension plane of an upper surface (30a) of the casing (30), so as to move between the closed position (P0) and the at least one open position (P1); and an actuator (311) configured to drive the cover between the closed position (P0) and the at least one open position (P1).

IPC Classes  ?

• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/45 - Interferometric spectrometry

Abstract

The invention relates to a device comprising a voxel structure (11) and a shell (12) that encloses the structure, which, when stacked along a direction, referred to as the stacking direction (z), forms at least a first level (1) and a second level (2), wherein each level comprises a first shell section (121) and a second shell section (122), respectively, wherein each shell section comprises a first cavity (1211) and a second cavity (1222), respectively, wherein each cavity comprises side walls (1211a), and a first set of voxels (111) and a second set of voxels (112), respectively, wherein each set of voxels comprises side faces (113) connecting a first face (114) and a second face (115) that are opposite one another, wherein the first and second cavities accommodate the first and second sets, wherein the side walls of the first and second cavities are configured to hold the side faces of the first and second sets, and wherein the levels are stacked such that the second face of the first set and the first face of the second set are at least partially in contact and form a one-piece structure.

IPC Classes  ?

• B29C 64/10 - Processes of additive manufacturing
• B22F 12/00 - Apparatus or devices specially adapted for additive manufacturingAuxiliary means for additive manufacturingCombinations of additive manufacturing apparatus or devices with other processing apparatus or devices
• B29C 64/30 - Auxiliary operations or equipment
• B33Y 40/00 - Auxiliary operations or equipment, e.g. for material handling
• B33Y 80/00 - Products made by additive manufacturing

Abstract

The present invention concerns bichromophoric compounds and methods of preparation thereof. Said invention also concerns the uses of these compounds, notably in the study of metallo-biomedical agents, notably metallo-pharmaceuticals or metallo-contrast agents, in particular for the study of the biotransformations of metallo-biomedical agents, notably metallo-pharmaceuticals or metallo-contrast agents, more particularly to localize and/or quantify in vitro or in vivo the biotransformations of metallo-biomedical agents, notably metallo-pharmaceuticals or metallo-contrast agents.

IPC Classes  ?

• C09B 57/02 - Coumarine dyes
• C09B 57/10 - Metal complexes of organic compounds not being dyes in uncomplexed form

Abstract

H22 HH +ee -, formula 1. The at least one first electrode comprises at least one redox couple My/Mx, insoluble in the electrolytic media, said at least one redox couple being arranged to exhibit at least two oxidation states and being suitable to be reduced from an oxidized state Myto a reduced state MxMM ypMM x, formula 2, wherein x and y are oxidation number. An absolute potential difference | ΔE | between a redox potential of the couple H+22, for a predetermined electrolytic media and a predetermined pressure range of gaseous dihydrogen, and a redox potential of the at least one couple My/Mx is lower than or equal to 0.6 V.

IPC Classes  ?

• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes
• H01M 8/0656 - Combination of fuel cells with means for production of reactants or for treatment of residues with means for production of gaseous reactants by electrochemical means
• C01B 3/00 - HydrogenGaseous mixtures containing hydrogenSeparation of hydrogen from mixtures containing itPurification of hydrogen
• C25B 1/02 - Hydrogen or oxygen
• C25B 1/50 - Processes
• C25B 11/081 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the element being a noble metal
• C25B 11/085 - Organic compound
• C25B 11/089 - Alloys

Abstract

The invention relates to a photovoltaic module (10) with integrated connections for assembly in series and in parallel, comprising a substrate (1) and a plurality of photovoltaic cells (2) which are identical and carried together by one face of the substrate, each photovoltaic cell being formed by a relevant portion of a single stack of layers of solid materials. The photovoltaic module further comprises portions of electrically conductive layers, which are carried by the substrate (1) and arranged to electrically connect the photovoltaic cells (2) according to a combination of at least one assembly in parallel with at least one assembly in series. Such a photovoltaic module is particularly suitable for forming part of a composite photovoltaic panel operating in tandem.

IPC Classes  ?

• H01L 31/046 - PV modules composed of a plurality of thin film solar cells deposited on the same substrate

Abstract

The present invention relates to a non-invasive prognostic method for assessing the prognostic of atrial cardiomyopathy in a subject in need thereof comprising determining a prognostic score based on groove epicardial adipose tissue variables and at least one additional demographic, metabolic or biologic variable. The present invention further relates to a method for preventing atrial cardiomyopathy occurrence in a subject, comprising determining the personalized course of the personalized course of clinical follow-up and/or preventive medical care for the subject based on the obtained prognostic score.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 30/00 - ICT specially adapted for the handling or processing of medical images

Abstract

Compositions related to recycled materials, optionally post-consumer/post-industrial polymeric materials (PC/IPM) and related methods, are generally described. The compositions may include a copolyester product from a transesterification reaction comprising crystallizable polymers or copolymers, of which at least one is present in a PC/IPM. The copolyester product may comprise heterolinkage dyads centered on diacid residue. Related methods may include combining crystallizable polymers or copolymers to form a mixture and subjecting the mixture to a temperature and/or stress to produce a copolyester product from a transesterification reaction.

IPC Classes  ?

• C08G 81/00 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
• C08G 63/183 - Terephthalic acids
• C08G 63/91 - Polymers modified by chemical after-treatment
• C08J 11/04 - Recovery or working-up of waste materials of polymers
• C08J 11/10 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation
• C08J 11/18 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material

Abstract

The invention relates to a set of luminescent light concentrators for wide-spectrum emission, the set being intended to be pumped by pump radiation having a pump wavelength and comprising: - a first luminescent light concentrator (C1), the first concentrator being made of a first material suitable for absorbing the pump radiation and then emitting first luminescent radiation (L1) having a first central emission wavelength within the first concentrator, - a second luminescent light concentrator, contiguous to the first concentrator, made of a second material suitable for absorbing the pump radiation and then emitting second luminescent radiation (L2) having a second central emission wavelength longer than the first wavelength within the second concentrator, - a third luminescent light concentrator, contiguous to the second concentrator, made of a third material suitable for absorbing the pump radiation and then emitting third luminescent radiation (L3) having a third central emission wavelength longer than the second wavelength within the third concentrator, such that the set of concentrators is suitable for emitting, through a first exit face, an output light emission containing the first, second and third central emission wavelengths and formed from a portion of each of the first luminescent radiation, second luminescent radiation and third luminescent radiation when the first, second and third luminescent light concentrators all absorb the pump radiation.

IPC Classes  ?

• F21V 8/00 - Use of light guides, e.g. fibre optic devices, in lighting devices or systems
• F21K 9/61 - Optical arrangements integrated in the light source, e.g. for improving the colour rendering index or the light extraction using light guides
• F21K 9/64 - Optical arrangements integrated in the light source, e.g. for improving the colour rendering index or the light extraction using wavelength conversion means distinct or spaced from the light-generating element, e.g. a remote phosphor layer
• F21V 9/32 - Elements containing photoluminescent material distinct from or spaced from the light source characterised by the arrangement of the photoluminescent material
• F21V 9/38 - Combination of two or more photoluminescent elements of different materials
• G03B 21/20 - Lamp housings
• G02B 19/00 - Condensers
• H01S 3/04 - Arrangements for thermal management
• H01S 3/08 - Construction or shape of optical resonators or components thereof
• H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light

Abstract

Clk1Pak1Clk-4Pak1Pak1 using validated shRNAs and combinations of FRAX597 and TG003, or FRAX597 and ML 167 synergized to reduce the growth and the colony-forming capacity of chemoresistant AML cells and sensitized them to chemotherapy. The combined treatment improved overall mouse survival and reduced disease burden in the chemoresistant AML mouse models. Moreover, AML patient cells that were primarily refractory or from a post chemotherapy relapse (n=21 ) exhibited a higher ex vivo sensitivity to the FRAX597 + TG003 combination in comparison with chemosensitive patients at diagnosis (n=28). Finally, combined PAK1 and CLK inhibition more effectively reduced disease progression in animals transplanted with the relapse sample than in those engrafted with the sample taken at diagnosis. Thus, the present invention relates to combination of PAK1 inhibitors and CLK inhibitors for preventing resistance to chemotherapy in patients suffering from acute myeloid leukemia.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

Method for controlling the motion of a target drone Method (100) for controlling a motion of a target drone (4) inside a geographical area of interest (Z), comprising the steps of : - acquisition (110), by a plurality of measuring devices located throughout the geographical area of interest, of a plurality of measures of values of wind parameters, the wind parameters comprising an amplitude and an orientation of the wind; - determining (130), from the plurality of measures, boundary conditions, defined as values of the wind parameters at a boundary of a domain surrounding the geographical area of interest; - determining (140), by using a first parametric function that depends on the boundary conditions only, a wind field, the wind field providing the values of the wind parameters in any point inside the domain; and, - controlling (160) the target drone by taking into account the wind field.

IPC Classes  ?

• G05D 1/606 - Compensating for or utilising external environmental conditions, e.g. wind or water currents
• G05D 105/22 - Specific applications of the controlled vehicles for transportation of humans
• G05D 107/17 - Spaces with priority for humans, e.g. populated areas, pedestrian ways, parks or beaches
• G05D 109/25 - Rotorcrafts

Abstract

The invention relates to a method for producing a crystalline tellurate comprising at least zinc; the method comprising the following steps: providing a cationic aqueous solution comprising Zn2+and Te6+ cations; co-precipitating the crystalline tellurate in liquid medium by applying a pH to the cationic aqueous solution, the pH being maintained at a value ranging from 5.00 to 10.00; and optionally separating the crystalline tellurate from the liquid medium.

IPC Classes  ?

• C01B 19/00 - SeleniumTelluriumCompounds thereof

Abstract

OF THE INVENTION LOCAL ADMINISTRATION OF RIPK2 INHIBITORS FOR THE CURATIVE TREATMENT OF ALLERGIC ASTHMA The present invention relates to a method for use in the treatment of Asthma. Here, the inventors identified the receptor-interacting serine/threonione protein kinas 2 (RIPK2) as a novel therapeutic target to improve Asthma-related diseases. They demonstrated that a local preventive administration of the RIPK2 inhibitor reduced AHR, airway eosinophilia, mucus production, Th2 cytokines and the alarmin IL-33. Moreover, they demonstrated the early role of IL-33 in the NOD1-dependent response of the epithelium to HDM. Therefore, the inventors demonstrated that the local interference of the NOD1 signaling pathway through RIPK2 inhibition may represent a new therapeutic approach in asthma. Other pulmonary diseases could also benefit of this treatment. Thus, the present invention relates to a method for use in the curative treatment of HDM-induced asthma comprising administrating to a subject in need thereof a therapeutically effective amount of an inhibitor of RIPK2.

IPC Classes  ?

• A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 11/06 - Antiasthmatics
• A61P 37/08 - Antiallergic agents

Abstract

The invention relates to a method implemented by computer means for quantifying irregularities of a surface of an anatomical region of a patient in at least one medical image, said method comprising the following steps: (a) obtaining at least one medical image representing said anatomical region, (b) segmenting said anatomical region or at least a part of said anatomical region, (c) detecting the actual contour of said anatomical region from said segmented anatomical region, (d) computing a smoothed contour of said anatomical region based on said actual contour, (e) calculating a score based on the distance between the actual contour and the smoothed contour.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/12 - Edge-based segmentation

Abstract

Compositions generally related to recycled polymers, copolyester products and related methods, are generally described. The compositions may include copolyester products comprising crystallizable polymers and/or copolymers, which may be present in a post-consumable/post-industrial polymeric material. The copolyester products may have characteristics amenable to enzymatic degradation. In some instances, a polymeric feedstock material can include the copolyester product.

IPC Classes  ?

• C08J 11/10 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation
• C08G 81/00 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers

Abstract

Here, the Inventors show that chronic IL- 1 -induced H2A.X signaling, which mediated DNA DSB response, in hippocampal neurons is a critical driver of cognitive deficits in chronic low grade neuroinflammation. They show that mice chronically infected with the brain- persisting T. gondii parasite display deficits in spatial memory consolidation without general memory loss. Extensive mapping of the neuroinflammatory landscape, beyond a latent T. gondii infection elicited type 1-like neuroinflammation, display elevated production of IL-1α and IL-1β in the hippocampus. Using a mouse model to specifically delete the IL-1 receptor from excitatory neurons, they uncovered that neuronal IL-1 signaling is required for the spatial memory deficits caused by latent T. gondii infection. By singling out a chronic exposure to IL- ip they found that IL-1β signaling in neurons indeed impairs spatial memory. Moreover, they showed that chronic exposure to IL-1β increases DNA DSB levels in neurons, and that neuronal H2A.X-dependent DSB response mediates the IL-1β-induced memory deficits. Importantly, neuronal DSBs were also increased upon T. gondii infection and the deficit in hippocampus- dependent spatial memory caused by T. gondii infection was prevented by the abrogation of neuronal H2A.Xdependent signaling. These results highlight the instrumental role of cytokine- induced DSB-dependent signaling in spatial memory defects elicited by a chronic infectious neuroinflammatory process. Accordingly, the present invention relates to a method of treating a subject suffering from cognitive deficit comprising administering to said subject a therapeutically effective amount of an inhibitor of IL- 1 -induced H2A.X signaling.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The invention relates to an electrochlorination electrode (1) and to the related manufacturing method, the electrode comprising an electrically conductive substrate (10), at least one catalytic layer (11) comprising metal and metalloid chemical elements, characterised in that the at least one catalytic layer (11) comprises ruthenium with a mass proportion of between 10% and 40%, titanium with a mass proportion of between 40% and 79%, and boron with a mass proportion of between 1% and 20%, the mass proportions being given relative to the total mass of the metal and metalloid elements in the at least one catalytic layer (11).

IPC Classes  ?

• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• C02F 1/467 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection
• C25B 1/26 - ChlorineCompounds thereof
• C25B 11/053 - Electrodes comprising one or more electrocatalytic coatings on a substrate characterised by multilayer electrocatalytic coatings
• C25B 11/093 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds at least one noble metal or noble metal oxide and at least one non-noble metal oxide

Abstract

1 235621011777 represents a functional group selected among a hydrogen and an aliphatic chain; or a pharmaceutical acceptable derivative thereof, for use as a medicament.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• A61K 31/69 - Boron compounds
• A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys

Abstract

NOMA uplink communications via Reconfigurable Intelligent surfaces are proposed based on the determination of Reconfigurable Intelligent surfaces sub-surface configurations compatible with NOMA successive interference cancellation requirements. For multiple sets of RIS sub-surfaces, the solution extends to reconfiguring user device to sub-channel attributions either in a coordinated mode or an uncoordinated mode based on a multi-player Multi- armed Bandit framework with zero-reward.

IPC Classes  ?

• H04B 7/04 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas
• H01Q 15/14 - Reflecting surfacesEquivalent structures
• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H01Q 1/24 - SupportsMounting means by structural association with other equipment or articles with receiving set
• H01Q 3/44 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the electric or magnetic characteristics of reflecting, refracting, or diffracting devices associated with the radiating element
• H01Q 21/28 - Combinations of substantially independent non-interacting antenna units or systems

Abstract

The invention relates to an actuator (1), comprising: at least two elongated deformable lumens (2), each lumen being connectable to a source of a fluid; and a fibre (4) wound around the at least two lumens, wherein the fibre surrounds a whole circumference of each of the at least two lumens over at least part of a length of each of the at least two lumens.

IPC Classes  ?

• F15B 15/10 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith characterised by the construction of the motor unit the motor being of diaphragm type
• B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid

Abstract

The present invention relates to an energy storage device (MCLk) comprising an energy storage element (CLk) supplying a voltage (Vclk) and a main switching circuit (COMk) forming an H-bridge the states of which are selectively controllable, the energy storage element (CLk) being able to deliver to connection terminals, in a first state, the voltage (Vclk), in a second state, the voltage inverted and, in a third state, a zero voltage configuring the storage device (MCLk) into a bypass state, bypassing the storage element (CLk), and further comprising a secondary bypass circuit (CCk) for bypassing the main switching circuit (COMk) electrically connected to the first and second connection terminals (S1, S2), able to configure a redundant fourth state bypassing the main switching circuit (COMk).

IPC Classes  ?

• H02M 1/32 - Means for protecting converters other than by automatic disconnection
• H02M 7/49 - Combination of the output voltage waveforms of a plurality of converters

Abstract

221612051423456789212051414 aryl group. The invention also relates to a method for preparing this composite material, to its use, to a kit for its preparation, and to a method for insulating a stator of an electric motor using this composite material. Finally, the invention relates to a non-crosslinked mixture of an epoxy resin comprising thermally conductive fillers and 4,4'-dithiodianiline, the content of thermally conductive filler being between 70% and 90% by weight relative to the total weight of the mixture.

IPC Classes  ?

• C08G 59/50 - Amines

Abstract

The invention relates to a method (10) for manufacturing a metal powder of an alloy reinforced with a ceramic nanoparticle dispersion, comprising spherical metal particles that form a metal matrix and ceramic nanoparticles distributed in the metal matrix, wherein the method comprises: introducing a precursor alloy metal powder intended to form the metal matrix into a fluidisation chamber of a fluidised bed reactor (E1); injecting at least one fluidisation gas into the fluidisation chamber at an injection flow rate that is defined so that the powder particles are suspended due to the drag force exerted by the gas in the chamber and are individualised (E2, E3); heating the suspended metal powder particles in the gas stream to a heating temperature and for a heating duration that are defined so as to allow ceramic nanoparticles to form on the surface of the metal particles and inside the metal particles (E4).

IPC Classes  ?

• B22F 1/05 - Metallic powder characterised by the size or surface area of the particles
• B22F 1/065 - Spherical particles
• B22F 1/12 - Metallic powder containing non-metallic particles
• B22F 1/142 - Thermal or thermo-mechanical treatment
• B22F 1/18 - Non-metallic particles coated with metal
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
• C22C 1/04 - Making non-ferrous alloys by powder metallurgy
• C22C 33/02 - Making ferrous alloys by powder metallurgy
• C22C 32/00 - Non-ferrous alloys containing at least 5% by weight but less than 50% by weight of oxides, carbides, borides, nitrides, silicides or other metal compounds, e.g. oxynitrides, sulfides, whether added as such or formed in situ
• B22F 1/16 - Metallic particles coated with a non-metal
• C22C 19/00 - Alloys based on nickel or cobalt
• C22C 19/05 - Alloys based on nickel or cobalt based on nickel with chromium
• C22C 38/18 - Ferrous alloys, e.g. steel alloys containing chromium

Abstract

The invention relates to a catalytic system based at least on a borohydrido-neodymocene, a dialkyl magnesium compound and a dialkyl zinc compound. The catalytic system can be used both in the homopolymerization of ethylene and in the copolymerization of ethylene and a 1,3-diene.

IPC Classes  ?

• C08F 4/54 - MetalsMetal hydridesMetallo-organic compoundsUse thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths, or actinides together with other compounds thereof
• C08F 10/02 - Ethene
• C08F 236/06 - Butadiene

Abstract

The invention relates to a catalytic system based at least on a borohydrido-neodymocene, a dialkyl zinc compound and an organomagnesium halide of formula RB-Mg-X in which RB comprises a benzene ring of which two carbon atoms are substituted, one of the two being substituted by a methyl, an ethyl or an isopropyl or forming a ring with the carbon atom which is its closest neighbour, the second carbon atom being substituted by a methyl, an ethyl or an isopropyl, the magnesium atom being in the ortho position in relation to each of said two carbon atoms, and X is a halogen atom. The catalytic system can be used both in the homopolymerization of ethylene and in the copolymerization of ethylene and a 1,3-diene.

IPC Classes  ?

• C08F 4/54 - MetalsMetal hydridesMetallo-organic compoundsUse thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths, or actinides together with other compounds thereof
• C08F 10/02 - Ethene
• C08F 8/10 - Acylation
• C08F 236/06 - Butadiene

Abstract

The invention relates to a method for the selective preparation of a polymer bearing a chain-end ketone function, comprising the following steps a) to c): a) conducting a polymerization reaction of ethylene or of a monomer mixture containing ethylene and a 1,3-diene in the presence of a borohydrido-neodymocene, b) conducting a reaction of a zinc dihalide with the reaction product of step a), c) conducting a reaction of an acid halide with the reaction product of step b).

IPC Classes  ?

• C08F 4/54 - MetalsMetal hydridesMetallo-organic compoundsUse thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths, or actinides together with other compounds thereof
• C08F 10/02 - Ethene
• C08F 8/10 - Acylation
• C08F 236/06 - Butadiene

Abstract

The invention relates to a process for the solid-state alkalinisation of a salt that comprises at least one transition metal and is deficient in an alkali metal, this process being characterised in that it comprises the following steps: a) mixing, in solid form, the salt that is deficient in (or does not comprise) an alkali metal with the corresponding alkali metal iodide, this iodide also being in solid form, to obtain a solid mixture; b) reacting the solid mixture to obtain molecular iodine and a salt of the alkali-metal-enriched transition metal; and, optionally, c) separating the molecular iodine from the solid mixture.

IPC Classes  ?

• C01B 25/45 - Phosphates containing plural metal, or metal and ammonium
• H01M 10/052 - Li-accumulators
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators
• C01G 45/12 - Complex oxides containing manganese and at least one other metal element
• C01G 49/00 - Compounds of iron
• C01G 51/00 - Compounds of cobalt
• C01G 53/00 - Compounds of nickel
• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers

Abstract

Melanoma cell plasticity plays a key role in the acquisition of resistance to therapy. TRIM24/TIF1α, which encodes for the tripartite RING/B-Box/Coil-coiled transcriptional coactivator, is frequently amplified in human melanomas. The inventors observed a strong correlation between elevated TRIM24 expression and metastatic disease, adverse outcome to immune checkpoint inhibitor therapy and a worse relapse-free survival. shRNA-mediated knock-down of TRIM24 decreased the migratory capacities and increased the sensitivity to BRAF inhibitors in two cellular melanoma models. RNA-sequencing analyses revealed that TRIM24 knock-down significantly represses undifferentiated/invasive transcriptional programs. A protac-based approach for degradation of Trim24 was shown to resensitize resistant melanoma cells to BRAF inhibitors. Thus, the present invention relates to a method for predicting the survival time of a patient suffering from melanoma comprising the step of measuring the level of TRIM24, and the use of TRIM24 inhibitor for treating melanoma, in particular resistant melanoma.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

Several gastrointestinal and gynecological malignancies have the potential to disseminate and grow in the peritoneal cavity. The occurrence of peritoneal carcinomatosis (PC) has been shown to significantly decrease overall survival in patients. Treatment of residual microscopic disease remains a challenge with new anticancer modalities development. Now, the inventors propose an innovative therapeutic management of peritoneal carcinomatosis (PC) that is bio-inspired and tumor-targeted by combining MSC-derived EVs and at least one chemotherapeutic agent for improved chemotherapy efficiency ty. In this work, the present inventors have shown in two different mice models of PC and with two different chemotherapeutic agents that, while the MSC-derived EVs from mice (mEVs) have no effect on mice suffering from PC, treatment with mEvs combined with chemotherapeutic agent has a superior therapeutic effect i.e. a significant reduction of the Peritonal Carcinomatosis Index (PCI) compared to treatment with chemotherapeutic agent alone. Thus, the present invention relates to the combination of EVs and at least one chemotherapeutic agent and uses thereof for the treatment of cancers such as PC.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 31/282 - Platinum compounds
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

xy oxyzz along the Z-axis, the specific zone (115) being located in a core of the solenoid (113).

IPC Classes  ?

• B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
• B22F 10/12 - Formation of a green body by photopolymerisation, e.g. stereolithography [SLA] or digital light processing [DLP]
• B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
• B29C 64/20 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B29C 64/241 - Driving means for rotary motion
• B29C 64/30 - Auxiliary operations or equipment
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
• H01F 7/02 - Permanent magnets
• H01F 7/20 - ElectromagnetsActuators including electromagnets without armatures
• H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets

Abstract

The present invention relates to a method to capture circulating tumor extracellular vesicles. Here the inventors describe a novel approach inspired by Chimeric Antigen Recognition (CAR)-like strategy, to selectively capture and locally accumulate circulating tumor EVs towards engrafted trapping cells, or endogenous trapping tissues of choice. Focusing on Prostate Cancer (PCa)-derived EVs as a proof of concept, they combined the pHluorin- genetic tagging of tumor EVs with the expression on target cells of the EV-Trap, a chimeric surface mCD8α receptor exposing various nanobodies directed against EVs' surface antigens (synthetic or tumor associated). They demonstrate how the simultaneous presence of PCa- derived CD63-pHluorin+, CD9-pHluorin+ or PSMA+ EVs in a system presenting GFP-TRAP or PSMA-TRAP accessible cell surfaces, results in significant accumulation and rerouting of PCa-derived pHluorin and PSMA EVs towards the EV-TRAP sites, both in vitro and in vivo in the zebrafish embryo. This approach has the potential to shed new lights on the role of EVs in various physiopathological processes, in particular on pre-metastatic niches formation. Thus, the present invention relates to a fusion protein comprising or consisting of an antigen binding compound, the mCD8α and optionally a domain which induce endocytosis (or internalisation).

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 35/00 - Antineoplastic agents
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

The present invention relates to an optomechanical microwave clock (100, 300, 400) integrated on a chip (103), comprising: - an optical waveguide (102) arranged on the chip (103),5 - a nano-cavity (101) arranged substantially parallel to the optical waveguide (102), wherein a modulation frequency of an optical mode excited in the nano-cavity (101) corresponds to an oscillation frequency of a mechanical mode of the nano-cavity (101), the modulated optical mode being evanescently coupled 10 to the optical waveguide (102) in at least one coupling region; wherein the optomechanical clock (100, 300, 400) further comprises: - mode-lock means configured to control the optomechanical oscillation stability of the optomechanical microwave clock, the mode-lock means comprising at least one of:15  contact-free radio-frequency mode-lock means,  acoustic passive auto-mode-lock means,  optical mode-lock means comprising an optical ring resonator See figure 3.20

IPC Classes  ?

• H03B 17/00 - Generation of oscillations using a radiation source and a detector
• H10N 30/30 - Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors
• G02F 1/365 - Non-linear optics in an optical waveguide structure
• H10N 30/87 - Electrodes or interconnections, e.g. leads or terminals
• G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference
• H10N 30/20 - Piezoelectric or electrostrictive devices with electrical input and mechanical output, e.g. functioning as actuators or vibrators
• H10N 30/85 - Piezoelectric or electrostrictive active materials

Abstract

The invention relates to a fluidic chip (101) comprising: - a first slide (100), the first slide (100) being made in a first material having an oxygen permeability of 10-9cm3(STP).cm.cm-2.s-1.cmHg-1or less at 25°C; - a second slide (104) comprising a channel (106), the second slide (104) being made in a second material having an oxygen permeability of 10-9cm3(STP).cm.cm-2.s-1.cmHg-1or less at 25°C; - a first adhesive layer (114) joining the first slide (100) to the second slide (104), the first adhesive layer (114) being made in a first adhesive composition having an oxygen permeability of 10-9cm3(STP).cm.cm-2.s-1.cmHg-1 or less at 25°C.

IPC Classes  ?

• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means

Abstract

The present invention relates to antagonist of PDGF-AA protein, for use in the treatment of cancer. Here in the present invention, they show for the first time that targeting PDGF signaling through a ligand trap approach is able to inhibit tumor progression by the reprogramming the activation status of the CAFs (Cancer -Associated Fibroblasts). The inventors found that PDGF-AA bind directly on CD8+T cells by reducing their activation and cytotoxic properties. Furthermore, the use of neutralizing PDGF-AA antibodies in PDAC mouse model, reduced tumor growth by enhancing CD8+ T cell anti-tumoral response. Thus, neutralizing PDGF-AA which acts as a novel immunological check-point target in PDAC therefore allows to restore beneficial anti-tumor immunity in cancer, and especially in PDAC.

IPC Classes  ?

• C07K 16/22 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors
• A61P 35/00 - Antineoplastic agents
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum

Abstract

An electrolyte composition which comprises a non-aqueous organic solvent, a conducting electrolyte salt, and at least one additive of formula (I): wherein M is a metal, X is H or -O-R and R is an alkyl and an electrochemical device comprising the electrolyte composition.

IPC Classes  ?

• H01M 10/0567 - Liquid materials characterised by the additives
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 10/0568 - Liquid materials characterised by the solutes
• H01M 10/0569 - Liquid materials characterised by the solvents

Abstract

The invention relates to a hybrid source for generating pairs of entangled photons (30), the hybrid source (100) comprising: - at least one AlGaAs waveguide (10) comprising AlGaAs, the at least one AlGaAs waveguide (10) having a second order nonlinearity, - at least one Silicon-on-Insulator (SOI) platform (20) comprising at least one layer (4, 6, 8) comprising silicon and at least one silicon waveguide (2) comprising silicon, the at least one AlGaAs waveguide (10) comprising AlGaAs being arranged on the at least one SOI platform (20) such that the at least one AlGaAs waveguide (10) is evanescently coupled to the at least one silicon waveguide (2) in a coupling region, wherein pairs of entangled photons (30) generated in the at least one AlGaAs waveguide (10) upon optical pumping are coupled into the at least one silicon waveguide (2).

IPC Classes  ?

• G02F 1/365 - Non-linear optics in an optical waveguide structure

Abstract

The present invention relates to a treatment of Age-related diseases (ARDs). Here, the inventors identified the AP-1 family of transcription factors (TFs) as a novel actionable therapeutic target to reverse the senescence phenotype and to ameliorate age-related chronic lung and cardiac disease outcomes by repurposing a small molecule AP-1 inhibitor (APli) T- 5224. They demonstrated that AP-1 inhibition induces an improve of ARDs such as Emphysema, lung fibrosis or cardiac function. Other cardiac and pulmonary diseases could also benefit of this treatment. Thus, the present invention relates to an AP-1 inhibitor for use in the treatment of ARDs in subjects in need thereof.

IPC Classes  ?

• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 9/00 - Drugs for disorders of the cardiovascular system

Abstract

The present invention relates to a composite material comprising a porous solid support and at least one malonamide non-covalently bonded to the surface of this porous solid support. The present invention also relates to a process for preparing such a material and also to the use thereof for extracting and recovering palladium from an acid leaching solution containing same.

IPC Classes  ?

• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/32 - Impregnating or coating
• C22B 3/24 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means by adsorption on solid substances, e.g. by extraction with solid resins
• C22B 11/00 - Obtaining noble metals

Abstract

The invention relates to a sputtering process of a target material in a vacuum environment comprising a sputtering target and plasmogenous process gas, wherein a transient electron accelerating pulse is applied to the sputtering target after plasma ignition, whereby applying said electron accelerating pulse involves applying a high negative bias voltage to the sputtering target during a period of time shorter than 1 microsecond, the bias voltage having an absolute value greater than 1 kV. This transitory regime of electron acceleration pulses is referred to as Fast High Voltage for lonization Improvement (FHiVI2). It can be operated alone or in combination with known sputtering processes, e.g. HiPIMS. The inventive process is suitable in sputtering deposition processes but also in other applications, e.g. for space propulsion.

IPC Classes  ?

• H01J 37/32 - Gas-filled discharge tubes
• F03H 1/00 - Use of plasma to produce a reactive propulsive thrust
• H01J 37/34 - Gas-filled discharge tubes operating with cathodic sputtering
• H05H 1/54 - Plasma accelerators

Abstract

uixxxxsMspsppp. The single or multiple scattering rate is a local physical characteristic representative of the local nature of the medium.

IPC Classes  ?

• G01S 7/52 - Details of systems according to groups , , of systems according to group
• G01N 29/26 - Arrangements for orientation or scanning
• G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging

Abstract

The present invention relates to a device for training a generative model configured to generate at least one synthetic 3D representation of myelin content and to a device and a computer-implemented method for obtaining at least one synthetic 3D image representative of myelin content for a patient using a trained generative model having training parameters obtained using the device for training.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation

Abstract

The invention concerns a test cell for an EQCM of an electrochemical system comprising a liquid electrolyte. It comprises: - a cell body (10) comprising an electrolyte cavity (11), a quartz resonator (12) coated with a first working electrode (FW) with an active material to be tested and being configured to provide a signal function of a mass variation of the first working electrode (FW), - a cell basis (20) comprising a connecting terminal (22) receiving the signal from the quartz resonator (12), The test cell (8) also comprises a cell holder (30), comprising: - a second electrolyte cavity connecting with the first electrolyte cavity, - a second working electrode, connected to the quartz resonator through the first and second electrolyte cavity (11), comprising similar material to the active material to be tested, - a counter electrode connected to the quartz resonator through the first and second electrolyte cavities (11).

IPC Classes  ?

• G01N 29/02 - Analysing fluids
• G01N 29/036 - Analysing fluids by measuring frequency or resonance of acoustic waves
• G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details
• H01M 10/52 - Removing gases inside the secondary cell, e.g. by absorption

Abstract

The invention relates to the combination of a βig-h3 antagonist and a PDGF-AA antagonist, for use in the prevention or treatment of a patient affected with cancer disease. In particular, the combination restore CD8+ T cell activation and thus anti-tumoral cytotoxic response. The cancer may be pancreatic ductal adenocarcinoma. PDGF-AA antagonist may be an anti-PDGF-AA neutralizing antibody or aptamer. Said βig-h3 antagonist may be an anti-βig-h3 neutralizing antibody or aptamer. The cancer is more particularly a cancer associated with a stroma expressing/secreting PDGF-AA and βig-h3. The invention also relates to methods of treatment of cancer disease with said combination.

IPC Classes  ?

• C07K 16/22 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

The invention relates to a circuit (1), comprising an input line (2), an output line (3), and a main switched-mode converter (4) that has an input connected to the input line and an output connected to the output line and produces operating harmonics, the circuit comprising at least one additional DC/AC converter (5) mounted in parallel with the main converter and arranged to inject, onto the one of the two lines that carries the sine-wave signal and in synchronisation with the sine wave, an additional signal depending on the operating harmonics of the main converter, the additional converter comprising at least one switching stage (7) consisting of a broadband semiconductor.

IPC Classes  ?

• H02P 9/48 - Arrangements for obtaining a constant output value at varying speed of the generator, e.g. on vehicle
• H02M 7/81 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal arranged for operation in parallel
• H02J 3/01 - Arrangements for reducing harmonics or ripples
• H02M 1/12 - Arrangements for reducing harmonics from AC input or output
• H02M 7/217 - Conversion of AC power input into DC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only

Abstract

Jam-3Jam-3Jam-3-deficiency rewired the transcriptional program of leukemia initiating cells (LIC) with upregulation of genes belonging to AP-l/TNF-α pathways. Transposition of results to human allowed to determine a new prognosis score called ATIC for AP-l/TNF-α Initiating Cells, complementary and distinct from the LSC17 score. Thus, the invention relates to a method for predicting the survival time of a patient suffering from an Acute Myeloid Leukemia (AML) based on the determination in a sample obtained from the patient of the expression levels of at least 7 genes selected in the group consisting in: JAM3, DUSP1, JUN, IER2, DUSP2, RGS1, H2BC8, PTGS2, NFKBID, PPP1R15A, NFKBIZ, ZFP36, SNORA28, TPT1, KLF2, BTG2, JUNB, JUNE), ATF3, UBC, SKIL, TAF7, SLFN12L, NR4A1, CHST2, GASS, SNORA31, HES1, EGR3, RPS13, PMAIP1, RHOB, MYL9, ZNF699, ZNF101, FOS, FJX1, RPP25L, HEY1, PTMA, GIMAP4, EFCAB11, FOSE, CD14, CCL4, CCL3, PF4, OSM, CD69, ITGA2B, VWF, MYCN and F2RL2.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention concerns at least one modulator of the metabolism and/or mitochondrial activity, in particular at least one inhibitor of the OXPHOS mitochondrial electron transport chain and/or inhibitor of the MVA pathway, for use for the prevention and/or treatment of neurofibroma. Combination of such modulators, in particular of an inhibitor of the OXPHOS mitochondrial electron transport chain with an inhibitor of the MVA pathway, as well as pharmaceutical compositions comprising them are also contemplated.

IPC Classes  ?

• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
• A61K 31/451 - Non-condensed piperidines, e.g. piperocaine having a carbocyclic ring directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

The present application relates to a process for preparing cyclic organopolysiloxane OC by depolymerization of at least one organopolysiloxane O selected from: - linear organopolysiloxanes, - branched organopolysiloxanes, - crosslinked organopolysiloxanes, or mixtures thereof; in the presence of a solvent, catalyzed by an alkali salt SA selected from alkali silanolates, alkali siliconates, or mixtures thereof, in which the amount of alkali salt used is between 0.01 and 2% by weight relative to the weight of organopolysiloxane O.

IPC Classes  ?

• C08G 77/04 - Polysiloxanes
• C08J 11/22 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material by treatment with organic oxygen-containing compounds

Abstract

A device for simulating a biological barrier comprising a multi-well plate covered by a port plate and sustained by a connection plate ensuring connection to a biochip.

IPC Classes  ?

• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave

Abstract

A device for interfacing a biochip.

IPC Classes  ?

• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

122 are as defined herein, or a pharmaceutically acceptable salt or solvate thereof, where said compounds of formula (I) are 3,5-dialkoxypyridine (DARQ) analogues of bedaquiline (BDQ) and may be used in the treatment of a nontuberculous mycobacterial (NTM) infection.

IPC Classes  ?

• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61P 31/04 - Antibacterial agents
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The invention relates to an isolated polynucleotide comprising a sequence having at least 90% sequence identity with sequence GGXaGGCAXbXcCCXdXeGGAAAGG (SEQ ID NO 1), wherein Xa, Xb, Xc, Xd and Xe are independently T or U, and its use in the treatment of Prader-Willi Syndrome and/or Prader Willi-like syndromes. The invention also relates to pharmaceutical compositions an isolated polynucleotide comprising a sequence having at least 90% sequence identity with sequence GGXaGGCAXbXcCCXdXeGGAAAGG (SEQ ID NO 1), wherein Xa, Xb, Xc, Xd and Xe are independently T or U and its use in the prevention and/or treatment of Prader-Willi Syndrome and/or Prader Willi-like syndromes. The present invention finds applications in the therapeutic and diagnostic medical technical fields.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 25/00 - Drugs for disorders of the nervous system
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The invention relates to a method for assembling at least two parts, the method comprising the following steps: - preparing a first element (4) comprising a first surface (8) having a general shape provided with a cavity (6); - preparing a second element (14) having a main surface (16) that has the same shape as at least one portion of the general shape of the first surface (8) of the first element (4); - applying a coating (26) to the first surface (8) of the first element (4) and to the main surface (16) of the second element (14); - placing the second element (14) on the first surface (8) of the first element (4) so that it fully covers the cavity (6); - placing the first element (4) and the second element (14) in a chamber (28) containing a fluid (30); and - pressurising the fluid (30) contained in the chamber (28).

IPC Classes  ?

• B81C 3/00 - Assembling of devices or systems from individually processed components
• H01L 23/473 - Arrangements for cooling, heating, ventilating or temperature compensation involving the transfer of heat by flowing fluids by flowing liquids
• H01L 21/48 - Manufacture or treatment of parts, e.g. containers, prior to assembly of the devices, using processes not provided for in a single one of the groups or

Abstract

The invention relates to a process for synthesis of a benzophenone or a benzophenone derivative which uses a metal base with a solvent selected from linear or cyclic carboxamides for activating a compound of formula (II) and allowing it to be coupled with a compound of formula (I) so as to give said benzophenone or said benzophenone derivative.

IPC Classes  ?

• C07C 45/45 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by condensation
• C07D 213/50 - Ketonic radicals
• C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07C 45/46 - Friedel-Crafts reactions
• C07D 317/54 - Radicals substituted by oxygen atoms

Abstract

The invention relates to a method, implemented by a control system, for controlling cell production in a bioreactor. The bioreactor comprises a cell culture vessel containing a culture medium and microcarriers, on the surface of which the cells grow. The method comprises dynamic adjustment of parameters during production. The dynamically-adjusted parameters include at least a temperature of the culture medium, a pH of the culture medium, a concentration of oxygen dissolved in the culture medium, and a quantity of microcarriers present in the vessel. The method improves the quality and quantity of the biomass produced in the bioreactor.

IPC Classes  ?

• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors

Abstract

The present invention relates to a method for extracting natural sea urchin pigments in a novel form (referred to as pigment matrix), to this pigment matrix and to the use thereof as a natural dye.

IPC Classes  ?

• C09B 61/00 - Dyes of natural origin prepared from natural sources

Abstract

The present invention relates to a method for identifying the types and/or subtypes of viral particles and/or extracellular vesicles using nanoporous membranes coupled with optical detection. The invention also relates to the use of this method, in particular for identifying/naming the type and/or subtypes of viral particles and/or extracellular vesicles present in a biological sample. More specifically, transporting viral particles and extracellular vesicles through nanopores allows the type of particle to be identified through its specific interaction with the nanopore and the modelling of this phenomenon, particularly using a bottleneck model.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present invention relates to antibodies and compositions that can be used to treat candidiasis.

IPC Classes  ?

• C07K 16/14 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from fungi, algae or lichens

Abstract

xy2z∞233 -33 2-33H-, and –Cl and optionally also substituted at least once by -COO-; where y is 1 to 3; and where z is 0 to 10.

IPC Classes  ?

• G01K 3/04 - Thermometers giving results other than momentary value of temperature giving mean valuesThermometers giving results other than momentary value of temperature giving integrated values in respect of time
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• G01K 11/20 - Measuring temperature based on physical or chemical changes not covered by group , , , or using thermoluminescent materials

Abstract

kk) representative of the correlation between the pixels of this region in the residual image and the pixels of the same region in the original image, wherein the size and the shape of each region are the same for all of the calculated correlation coefficients, and wherein the predetermined size of each region is greater than nine pixels; 3) constructing (56) a measurement of the quality of the reconstructed image on the basis of the coefficients calculated in step 2).

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/254 - Analysis of motion involving subtraction of images
• H04N 19/154 - Measured or subjectively estimated visual quality after decoding, e.g. measurement of distortion
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• H04N 17/00 - Diagnosis, testing or measuring for television systems or their details

Abstract

The invention relates to a method for manufacturing a microelectronic device (100) having a cavity (20) comprising at least one transistor (11a), the method comprising at least the following step:  Removing the materials from a stack of dielectric layers (1) of the microelectronic device (100), selectively with respect to the materials of a set of interconnection lines (2) and a cover (3) of an active area by vapor-phase HF etching, thus forming the cavity (20) extending laterally in a direction x at least until exposing the walls of the set of interconnection lines (2) opposite the first transistor (11a), and in a direction z perpendicular to the direction x until exposing an upper face of the cover (3) of the active area.

IPC Classes  ?

• H01L 21/768 - Applying interconnections to be used for carrying current between separate components within a device
• H01L 23/532 - Arrangements for conducting electric current within the device in operation from one component to another including external interconnections consisting of a multilayer structure of conductive and insulating layers inseparably formed on the semiconductor body characterised by the materials
• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
• H01L 23/367 - Cooling facilitated by shape of device

Abstract

in vitroinvivovivo, as it meets the performance requirements generally expected in this field, such as sensitivity and chemical stability, particularly over the long term.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
• H01L 29/808 - Field-effect transistors with field effect produced by a PN or other rectifying junction gate with a PN junction gate

Abstract

1lim*lim*

IPC Classes  ?

• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation

Abstract

Ackr4Ackr4 as a biomarker for prognosing clinical outcome in a male subject suffering from a B-Cell Non-Hodgkin Lymphoma. It also relates to methods for predicting clinical outcome and methods for monitoring the effect of a therapy or the progression of a B-Cell Non-Hodgkin lymphoma. Another aspect of the invention relates to the ACKR4 protein for use in the treatment or the prevention of a B-Cell Non-Hodgkin Lymphoma.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention relates to anti-ACE2 peptidase domain single domain antibodies. Further, the present invention relates to anti-ACE2 single domain antibodies comprising the CDR regions of the present single domain antibodies, polypeptides comprising thereof such as multimers thereof, and fusion proteins comprising thereof, as well as pharmaceutical compositions comprising the single domain antibodies, the polypeptides comprising thereof such as the multimeric single domain antibodies thereof, or the fusion proteins comprising thereof, and their use for treating diseases caused by a virus having ACE2 as receptor.

IPC Classes  ?

• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

The description relates to a battery device comprising: - electrodes comprising an anode and a cathode; and - an electrolyte, between the electrodes, comprising a crystalline material having the composition M2B2O5.x(HOH).y(NOH), where M and N are alkaline elements or hydrogen, or mixtures of alkaline elements or hydrogen, B is titanium, O and H denote the elements oxygen and hydrogen, respectively, and x and y are between 0 and 4 and denote the presence of H+, OH-, N+ ions, which are capable of migrating into the crystalline material. In particular, at least one type of ion from among H+, OH-, N+ and M+ is movable so as to migrate into the crystalline material towards at least one of the electrodes, and the at least one of the electrodes is made of a material capable of carrying out a chemical interaction with at least one of the H+, OH-, M+ and N+ ions.

IPC Classes  ?

• H01M 10/0561 - Accumulators with non-aqueous electrolyte characterised by the materials used as electrolytes, e.g. mixed inorganic/organic electrolytes the electrolyte being constituted of inorganic materials only
• H01M 10/26 - Selection of materials as electrolytes
• H01M 10/30 - Nickel accumulators
• H01M 10/32 - Silver accumulators
• H01M 8/1016 - Fuel cells with solid electrolytes characterised by the electrolyte material
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/42 - Alloys based on zinc
• H01M 4/46 - Alloys based on magnesium or aluminium
• H01M 4/48 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
• H01M 4/485 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of mixed oxides or hydroxides for inserting or intercalating light metals, e.g. LiTi2O4 or LiTi2OxFy
• H01M 4/54 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of silver
• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 8/083 - Alkaline fuel cells
• H01M 10/02 - Details
• H01M 10/052 - Li-accumulators
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 10/34 - Gastight accumulators

Abstract

Disclosed is a surface acoustic wave sensor (1), called SAW sensor (1), comprising, from a lower face (2) to an upper surface (3) of said SAW sensor: a piezoelectric substrate (4), at least one interdigital transducer (IDT) (5), and a layer (6) of polytetrafluoroethylene (PTFE), an upper face of which entirely forms the upper surface of the SAW sensor, said PTFE layer having a thickness of between 50 nm and 4 μm.

IPC Classes  ?

• G01N 29/02 - Analysing fluids
• G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details

Abstract

A method for cleaning a porous separation membrane, comprises the following steps : - providing an electro-osmotic membrane; - juxtaposing, preferably contacting, the porous separation membrane to be cleaned with the electro-osmotic membrane; - contacting the porous separation membrane and the electro-osmotic membrane with a volume of an electrolyte; - interposing the electro-osmotic membrane or the electro-osmotic membrane and the porous separation membrane between a first electrode and a second electrode contacting each the volume of electrolyte; and - applying an alternating electrical field between the first and second electrodes to induce a back and forth movement of the electrolyte through the porous separation membrane. The invention also relates to systems implementing this method.

IPC Classes  ?

• B01D 61/42 - ElectrodialysisElectro-osmosis
• B01D 65/08 - Prevention of membrane fouling or of concentration polarisation

Abstract

The invention relates to a vacuum evaporation deposition device (30) comprising: - a deposition housing or enclosure; - a deposition support (32); - evaporation means (36) for evaporating a material towards the deposition substrate (32); - reactive gas injection means (41) for injecting a reactive gas into the chamber; - means forming a cover (2) around the deposition substrate, extending from the deposition support, the axis XX' forming an axis of rotational symmetry perpendicular to the surface of the deposition support and centred thereon, the reactive gas injection means (41) comprising a duct provided with a plurality of openings for injecting a reactive gas with an initial momentum distribution that is rotationally symmetrical about the axis XX'.

IPC Classes  ?

• C23C 14/24 - Vacuum evaporation
• C23C 14/00 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
• C23C 14/08 - Oxides
• C23C 14/54 - Controlling or regulating the coating process
• C23C 14/14 - Metallic material, boron or silicon
• C23C 14/50 - Substrate holders
• C23C 14/06 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
• C23C 14/04 - Coating on selected surface areas, e.g. using masks

Abstract

The present invention relates to an in vitro method for analyzing DNA interactions and kits for implementing said method. The method of the invention is more particularly useful for analyzing interactions between i) single-strand DNA (ssDNA) and ii) double-strand or single- strand DNA (dsDNA or ssDNA).

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

The present invention relates to a cyanide-free silver-plating bath, characterised in that it consists of an aqueous solution, adjusted to a pH of 1.5 to 2 using citric acid, based on silver iodide and potassium iodide, the silver iodide being present in a proportion of 40 to 60 g per litre of aqueous solution, i.e. 18.4 to 27.6 g/l of Ag0 and the potassium iodide being present in a proportion of 425 to 475 g per litre of aqueous solution, excluding any cyanide.

IPC Classes  ?

• C25D 3/46 - ElectroplatingBaths therefor from solutions of silver

Abstract

Using NLRP3-deficient U937 cells reconstituted with doxycycline-inducible NLRP3 variants in response to NLRP3 induction, the present inventors have developed a novel functional cell-based assay to screen for NLRP3 variants that uncouples NLRP3 induction, priming and activation. The inventors studied and characterized 38 NLRP3 variants by assessing pyroptosis and IL-1β/18 5 secretion in, priming and/or activation. The results were confirmed in primary monocytes from patients carrying different variants. The present invention pertains to a method for characterizing NLRP3 mutations that allows discriminating gain-of-function mutants from polymorphism without any impact on NLRP3 activity. The invention also relates to methods for the diagnosis of NLRP3- associated autoinflammatory diseases and for predicting a response to NLRP3 inhibitors based on 10 the detection of specific NLRP3 mutations in a sample obtained from a patient. The invention also relates to new NLRP3 inhibitors.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease

Abstract

The present patent application relates to the field of skin tissue engineering and aims to generate a reconstructed skin model. The present invention more particularly provides processes to create a three-dimensional construct possessing key features reminiscent of native skin tissue, including capillaries, skin appendages and immune cells. The present invention further relates to this three-dimensional skin construct, and applications thereof.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present invention concerns a pharmaceutical composition for use in the prevention or treatment of cerebral cavernous malformations (CCM) comprising a transient receptor potential vanilloid 4 (TRPV4) inhibitor.

IPC Classes  ?

• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 31/18 - Sulfonamides
• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

xyy is deposited on the surface of the substrate, where metal silicide M is a transition metal, x is an integer selected from the group consisting of 1, 2, 3, 4 and 5, and y is an integer selected from the group consisting of 1, 2, 3 and 4; b) depositing a mixture comprising an organic resin, preferably a furan or phenolic resin, and a metal silicon powder, on the surface of the substrate obtained at the end of step a), by means of which, at the end of step b), a composite material is obtained that comprises an ultra-high temperature ceramic matrix reinforced with carbon fibres.

IPC Classes  ?

• C04B 41/00 - After-treatment of mortars, concrete, artificial stone or ceramicsTreatment of natural stone
• C04B 41/45 - Coating or impregnating
• C04B 41/52 - Multiple coating or impregnating
• C04B 41/89 - Coating or impregnating for obtaining at least two superposed coatings having different compositions
• C04B 111/00 - Function, property or use of the mortars, concrete or artificial stone

Abstract

2222 2 in the solution; collecting a flow of solution exiting the subterranean formation or the sample thereof; and measuring the concentration of the surfactant in the flow of solution exiting the subterranean formation or the sample thereof.

IPC Classes  ?

• C09K 8/584 - Compositions for enhanced recovery methods for obtaining hydrocarbons, i.e. for improving the mobility of the oil, e.g. displacing fluids characterised by the use of specific surfactants
• C09K 8/594 - Compositions used in combination with injected gas
• E21B 41/00 - Equipment or details not covered by groups
• E21B 49/08 - Obtaining fluid samples or testing fluids, in boreholes or wells

Abstract

The present invention relates to the use of KMT inhibitors and in particular of Suv39h1 inhibitors to increase immune response, and in particular immune cell mediated response, notably elicited by a vaccine or immunogenic composition.

IPC Classes  ?

• A61K 31/546 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine containing further heterocyclic rings, e.g. cephalothin
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a method for balancing an electrical system with a view to recharging a power battery, which comprises electrochemical cells, of said system, the battery (BAT) comprising at least three current lines (LT1, LT2, LT3) each comprising a plurality of series-connected elementary modules forming a distributed multilevel inverter in the battery (BAT), the method comprising a first step (E10) of detecting an imbalanced state-of-charge state between at least two lines of said three current lines (LT1, LT2, LT3), a second step (E11) of commanding charging of said three current lines (LT1, LT2, LT3) from a charging line (25), and a third step (E12) of controlling voltage reference setpoints during which charging currents specific to each current line carry out state-of-charge rebalancing between said three current lines.

IPC Classes  ?

• H02J 3/26 - Arrangements for eliminating or reducing asymmetry in polyphase networks
• B60L 58/20 - Methods or circuit arrangements for monitoring or controlling batteries or fuel cells, specially adapted for electric vehicles for monitoring or controlling batteries of two or more battery modules having different nominal voltages
• H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from AC mains by converters
• B60L 53/62 - Monitoring or controlling charging stations in response to charging parameters, e.g. current, voltage or electrical charge
• B60L 53/63 - Monitoring or controlling charging stations in response to network capacity
• B60L 58/21 - Methods or circuit arrangements for monitoring or controlling batteries or fuel cells, specially adapted for electric vehicles for monitoring or controlling batteries of two or more battery modules having the same nominal voltage

Abstract

According to the invention, a system is equipped with a cellular battery assembly (EB) comprising modules (MC) that contain cells for storing electrical energy and that are secured by first screws (V1) to crossbars (TB) separating them and under which a cooling device (DR) is installed, the cooling device being placed above a protective plate (PP). Each module (MC) comprises two ends each provided with two connection terminals (BOC) connected to corresponding connection terminals (BOC) of neighbouring modules (MC) via inter-module conductive lines (LC) that are fixedly secured by second screws (V2), and a power board to which the cells are coupled and generating, when not in operation, a zero voltage difference between the connection terminals (BOC), the heads of the first and second screws (V1, V2) being accessible from beneath the cellular battery assembly in order to allow the module (MC) to be uninstalled by unscrewing these screws, after movement of the cooling device (DR) and protective plate (PP).

IPC Classes  ?

• H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
• B60L 53/80 - Exchanging energy storage elements, e.g. removable batteries
• H01M 10/613 - Cooling or keeping cold
• H01M 10/625 - Vehicles
• H01M 10/6556 - Solid parts with flow channel passages or pipes for heat exchange
• H01M 10/6568 - Liquids characterised by flow circuits, e.g. loops, located externally to the cells or cell casings
• H01M 50/244 - Secondary casingsRacksSuspension devicesCarrying devicesHolders characterised by their mounting method
• H01M 50/249 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders specially adapted for aircraft or vehicles, e.g. cars or trains
• H01M 50/284 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders with incorporated circuit boards, e.g. printed circuit boards [PCB]
• H01M 50/291 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders characterised by spacing elements or positioning means within frames, racks or packs characterised by their shape
• H01M 50/298 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders characterised by the wiring of battery packs
• H01M 50/505 - Interconnectors for connecting terminals of adjacent batteriesInterconnectors for connecting cells outside a battery casing comprising a single busbar
• H01M 50/517 - Methods for interconnecting adjacent batteries or cells by fixing means, e.g. screws, rivets or bolts
• B60K 1/04 - Arrangement or mounting of electrical propulsion units of the electric storage means for propulsion
• B60L 50/64 - Constructional details of batteries specially adapted for electric vehicles
• B60L 50/60 - Electric propulsion with power supplied within the vehicle using propulsion power supplied by batteries or fuel cells using power supplied by batteries
• B60L 58/26 - Methods or circuit arrangements for monitoring or controlling batteries or fuel cells, specially adapted for electric vehicles for monitoring or controlling batteries for controlling the temperature of batteries by cooling

Abstract

Acoustic scanning microscopy technique, in which the probe is formed by at least one acoustically resonant gas bubble immersed in a liquid medium (16) and excited by an acoustic wave that propagates in the liquid medium (16). The resonant response of the bubble is measured with a transducer (8).

IPC Classes  ?

• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 29/12 - Analysing solids by measuring frequency or resonance of acoustic waves
• G01N 29/24 - Probes

Abstract

The present disclosure relates to pyrazolo[1,5-a][1,3,5]triazine derivatives and uses thereof. In particular the present disclosure relates to compounds of formula (I) which are 2- substituted 8-halogeno-N4-(4-(pyridin-2-yl) benzyl) pyrazolo[1,5-a][1,3,5] triazine-2,4-diamine, pharmaceutical compositions comprising these compounds, the preparation of these compounds 5 and uses thereof, in particular as a molecular glue degrader.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 35/00 - Antineoplastic agents

Abstract

22, a base and a catalyst. The method of the invention falls within a circularity approach to boron, enabling recycling of (pseudo-)haloborane compounds, which are a waste commonly encountered in boron chemistry, to hydroboranes with higher added values.

IPC Classes  ?

• C07F 5/02 - Boron compounds

Abstract

The invention relates to a method for obtaining a high-resolution image of a sample (2), comprising the following steps: - a) generating a sequence of successive pseudo-random illuminations, an empirical statistical property of the sequence having a predetermined value, the sequence of pseudo-random illuminations being optimized so as to increase the uniformity of the empirical statistical property; - b) exposing the sample to the sequence of pseudo-random illuminations; - c) acquiring a plurality of low-resolution images of the sample by means of an image-capturing device (40), each low-resolution image being acquired while the sample is exposed to one of the pseudo-random illuminations of the sequence; - d) calculating a measured value of an empirical statistical property of the plurality of low-resolution images, - e) determining, on the basis of the predetermined value of the empirical statistical property of the sequence of pseudo-random illuminations, a model of the empirical statistical property of the plurality of low-resolution images, - f) determining the high-resolution image by minimizing, by fitting of the model, a deviation between the model of the empirical statistical property of the plurality of low-resolution images and the measured value of the empirical statistical property of the plurality of low-resolution images.

IPC Classes  ?

• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06T 5/92 - Dynamic range modification of images or parts thereof based on global image properties

Abstract

The present invention relates to a method for sol-gel preparation of a polymer-inorganic hybrid composition, comprising the following steps: a-preparing a composition comprising (a1) a thermostable polymer, (a2) a metal oxide-based or silicon-based compound chosen from: (a2a) an organoalkoxysilane of general formula (I) R2mmSi(OR14-m4-m, (a2b) inorganic nanoparticles, (a2c) a mixture of an organoalkoxysilane of general formula (I) and of inorganic nanoparticles; b- mixing the composition in the presence of an aqueous medium, with stirring for the time required to hydrolyze and condense the organic-inorganic hybrid network. The present invention further relates to the hybrid composition that can be obtained by this method and to a method for coating a composite substrate, comprising the following successive steps: A- depositing at least one layer of said composition on a composite substrate; B- depositing at least one subsequent coating layer on said substrate coated with the layer obtained in step A). The present invention furthermore relates to the coated composite substrate that can be obtained by this method and to the use of the composition according to the invention as an undercoat of a composite substrate in order to protect said substrate and/or to improve the adhesion on said substrate, during the deposition of a subsequent layer.

IPC Classes  ?

• C09D 5/00 - Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects producedFilling pastes
• C09D 101/28 - Alkyl ethers
• C09D 179/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C09D 183/04 - Polysiloxanes
• C09D 183/10 - Block or graft copolymers containing polysiloxane sequences

Abstract

Elementary cell for electrolysis, the elementary anode having a channel for bubbles of a first gas, the elementary cathode having a channel for bubbles of a second gas, wherein the elementary anode and/or the elementary cathode extend locally into the elementary main channel near the mouth, along a downstream portion of the mouth in an average direction of the elementary main channel.

IPC Classes  ?

• C25B 11/03 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form perforated or foraminous
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/07 - Common duct cells
• C25B 9/13 - Single electrolytic cells with circulation of an electrolyte

Abstract

The present disclosure relates to antibody-drug conjugates, wherein the drug is a pyrazolo[1,5-a][1,3,5]triazine derivative or a pyrazolo[1,5-a]pyrimidine derivative. In particular the drug can be a 2-substituted 8-halogeno-N4-(4-(pyridin-2-yl) benzyl) pyrazolo[1,5-a][1,3,5] triazine-2,4-diamine. Such antibody-drug conjugates are useful in particular in treating proliferative diseases including cancers.

IPC Classes  ?

• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

Abstract

The invention relates to a system for the additive manufacture of an anisotropic bonded magnet from an initial material formed of a binder matrix and particles of anisotropic magnetic material, the system comprising an extruder body, a nozzle intended to eject a filament of initial material in viscous form, and an alignment system (30) surrounding the nozzle and generating a vertical magnetic induction (B) capable of aligning the magnetic material particles such that their easy magnetisation axis is oriented in the direction of magnetic alignment in the filament before it is ejected. The alignment system (30) consists of a first ring (31) made of permanent magnet material having radial magnetisation, a second ring (32) made of permanent magnet material having axial magnetisation, a yoke (34) made of magnetic material and an adapter (33) made of non-magnetic material. The invention also relates to manufacturing methods based on this system.

IPC Classes  ?

• H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets
• B22F 12/53 - Nozzles
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor

Abstract

Ceibapentandrapentandra. The fragrant matter is in particular plant matter such as flowers.

IPC Classes  ?

• A61K 8/30 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
• A61K 8/9783 - Angiosperms [Magnoliophyta]
• A61Q 13/00 - Formulations or additives for perfume preparations

Abstract

The Inventors hypothesized that the PIK3CA/AKT/mTOR pathway was abnormally affected in patients with HFMH. They identified a somatic gain-of-function mutation of PIK3CA in 5 pediatric patients with hemifacial myohyperplasia, a rare cause of facial asymmetry exclusively involving facial muscles. To understand the physiopathology of muscle hypertrophy, they created a mouse model carrying specifically a PIK3CA mutation in skeletal muscles. PIK3CA gain-of-function mutation led to striated muscle cell hypertrophy, mitochondria dysfunction and hypoglycemia with low circulating insulin levels. A PIK3CA inhibitor, namely Alpelisib, was able to prevent and to reduce muscle hypertrophy in the mouse model. They then concluded that PIK3CA is a relevant target to induce skeletal muscle hypertrophy. The present invention relates to a PIK3CA protein or fragment thereof and/or an agent for PIK3CA protein expression for use in promoting skeletal muscle hypertrophy in a subject in need thereof.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/45 - Transferases (2)
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines

Abstract

The present invention pertains to a process for preparing a composition comprising a combined cell population comprising at least 90% Natural Killer (NK) cells and gamma-delta T (γδT) lymphocytes. The present invention also pertains to said composition comprising a combined cell population comprising NK cells and γδT lymphocytes and its use in medicine.

IPC Classes  ?

• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

in vitroin vitro method for predicting cognitive decline in a subject comprising the step of determining the level of at least one metabolite selected in the group consisting of 3-hydroxybutyrate, acetone, triglyceride 48:3, glucose, citrate, succinate, methionine, serine, sphingomyelin d18:1/C26:0 in a biological sample obtained from the subject.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/66 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood sugars, e.g. galactose
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol

Abstract

The invention relates to a system for controlling the deposition of thin layers by gas phase growth in a deposition reactor (10), the gas phase corresponding to a gaseous state or a plasma state, the control system comprising: - a hollow cathode lamp (2); - an optical cavity (3) that contains at least two mirrors (31) and is configured such that light emitted by the light source (2) is trapped in the optical cavity (3) and interacts with the gas phase, resulting in the deposition of thin layers; and - a light analysis system (4) which is configured to analyze light emitted by the hollow cathode lamp (2) and passing through the optical cavity (3), by measuring the optical absorbance of at least one species of the gas phase penetrated by said light.

IPC Classes  ?

• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/28 - Investigating the spectrum
• G01J 3/42 - Absorption spectrometryDouble-beam spectrometryFlicker spectrometryReflection spectrometry
• G01N 21/03 - Cuvette constructions
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/433 - Modulation spectrometryDerivative spectrometry
• C23C 14/54 - Controlling or regulating the coating process
• C23C 16/52 - Controlling or regulating the coating process
• G01J 3/18 - Generating the spectrumMonochromators using diffraction elements, e.g. grating
• H01J 37/32 - Gas-filled discharge tubes
• G01N 21/84 - Systems specially adapted for particular applications

Abstract

The invention relates to a system for controlling the deposition of thin layers by gas phase growth in a deposition reactor (10), the gas phase corresponding to a gaseous state or a plasma state, the control system comprising: - a continuous light source (2); - an optical cavity (3) comprising at least two mirrors, and configured such that a light emitted by the light source is trapped in the optical cavity and interacts with the gas phase, resulting in the deposition of thin layers; and - a spectrometer (4) which is configured to analyze light emitted by the light source (2) and passing through the optical cavity (3), by measuring the optical absorbance of at least one species of the gas phase penetrated by said light.

IPC Classes  ?

• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/28 - Investigating the spectrum
• G01J 3/42 - Absorption spectrometryDouble-beam spectrometryFlicker spectrometryReflection spectrometry
• G01N 21/03 - Cuvette constructions
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• C23C 14/54 - Controlling or regulating the coating process
• C23C 16/52 - Controlling or regulating the coating process
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/18 - Generating the spectrumMonochromators using diffraction elements, e.g. grating
• H01J 37/32 - Gas-filled discharge tubes
• G01N 21/84 - Systems specially adapted for particular applications
• G01P 5/26 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring the direct influence of the streaming fluid on the properties of a detecting optical wave

Abstract

222; - one or more organic acids selected from monocarboxylic acids comprising at least 10 carbon atoms and polycarboxylic acids; and - one or more gelling agents. The invention also relates to the use of this composition for disassembling a structure comprising at least two elements secured to one another by means of an adhesive joint, and to a method for disassembling such a structure.

IPC Classes  ?

• C08J 11/06 - Recovery or working-up of waste materials of polymers without chemical reactions
• C09J 5/00 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers

Abstract

The invention relates to a system for controlling the deposition of thin layers by gas phase growth in a deposition reactor (10), the gas phase corresponding to a gaseous state or a plasma state, the control system comprising: - a continuous light source (2); and - a spectrometer (4) configured to analyze a light emitted by the light source (2) by measuring the optical absorbance of at least one species of the gas phase penetrated by said light, the spectrometer (4) comprising a dispersion stage (400), the dispersion stage being a scalar diffraction grating, the spectrometer (4) not having a diffraction order separation stage.

IPC Classes  ?

• G01J 3/18 - Generating the spectrumMonochromators using diffraction elements, e.g. grating
• G01J 3/28 - Investigating the spectrum
• G01J 3/42 - Absorption spectrometryDouble-beam spectrometryFlicker spectrometryReflection spectrometry
• G01N 21/03 - Cuvette constructions
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• C23C 14/54 - Controlling or regulating the coating process
• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• C23C 16/52 - Controlling or regulating the coating process
• H01J 37/32 - Gas-filled discharge tubes
• G01N 21/84 - Systems specially adapted for particular applications

Abstract

in vitroin vitro detection and/or quantification of a biological or chemical substance of interest in a sample by detecting the emission of luminescence emitted by inorganic photoluminescent nanoparticles, comprising at least the steps of: arranging inorganic photoluminescent nanoparticles with a vanadate or vanadate/phosphate matrix of a particular formula coupled to a coupling agent for coupling to the substance of interest; placing the photoluminescent particles in contact with the substance of interest under conditions for coupling the substance of interest with the coupling agent; exciting the matrix of inorganic photoluminescent nanoparticles, by radiation with a wavelength of 240 nm to 330 nm; detecting the emission of luminescence by the inorganic photoluminescent nanoparticles; and determining the presence and/or concentration of the substance of interest by interpreting the measurement of the emission of luminescence by the particles.

IPC Classes  ?

• C09K 11/77 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing rare earth metals
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• G01N 21/64 - FluorescencePhosphorescence

Abstract

The invention relates to an antenna array system (1) comprising: a main powered antenna (30) which is configured to emit a beam directed in a plurality of main directions, the main powered antenna operating in a first frequency band; a set of parasitic antennas (10.1, 10.2, 10.3, 10.4) which are arranged so as to form a first envelope by concentrically surrounding the main powered antenna (30), each antenna comprising a substrate (13.1, 13.2, 13.3, 13.4) which is made of dielectric material, has a face oriented towards the outside of the envelope and provided with a parasitic radiating element (11.1, 11.2, 11.3, 11.4), and is provided with a ground plane, the parasitic radiating element (11.1, 11.2, 11.3, 11.4) being connected to the ground plane via a reactive load (12.1, 12.2, 12.3, 12.4), each parasitic antenna being configured to emit a beam directed in a main direction, the reactive loads (12.1, 12.2, 12.3, 12.4) being configured to selectively activate electromagnetic coupling between the main powered antenna and a pair of parasitic antennas in order to modify the directivity of the main powered antenna.

IPC Classes  ?

• H01Q 3/44 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the electric or magnetic characteristics of reflecting, refracting, or diffracting devices associated with the radiating element
• H01Q 5/40 - Imbricated or interleaved structuresCombined or electromagnetically coupled arrangements, e.g. comprising two or more non-connected fed radiating elements
• H01Q 9/36 - Vertical arrangement of element with top loading
• H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart

Abstract

The invention relates to a method for surface micro- or nano-structuring of a material, characterised in that it comprises an irradiation step (a) consisting in irradiating a localised surface zone of the material with a focused ionic gas beam, the beam being defined by: - a kinetic energy of the ions of between 5 and 30 keV for hydrogen ions, between 10 and 60 keV for helium ions or between 20 and 500 keV for ions having an atomic mass unit of greater than or equal to 12; - a flux set to a value of between 1013and 1018ions/cm2/s; and - a fluence having a value which is derived from a database establishing the link between the nature of the material, the type of ions used and the associated kinetic energy, and the value of the flux in order to obtain surface micro- or nano-structuring of the material, consisting of one or more micro- or nano-structures in the form of sealed hollow blisters.

IPC Classes  ?

• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate