Method and systems are provided for defining test sample read count limits for a range of microbial sequence reads. A computing device may generate a stabilization framework usable to determine a viability of a stabilization solution to stabilize a particular microbial species. The stabilization framework may include a first read count limit defined based on an enumerated abundance of the microbial species in a control sample multiplied by a first sequencing range value. The computing device may receive a read count value corresponding to an enumerated abundance of the microbial species in a mixture comprising a biological sample and the stabilization solution. The stabilization framework maybe applied to the read count value to generate an output based on whether the read count value exceeds the first read count limit. The computing device may then select, the stabilizing solution for use with subsequent biological samples.
(1) Apparatus for taking blood samples; blood collection tubes; blood sampling tubes; blood collection containers; blood collection tubes for the preservation, storage, and transportation of blood and blood derivatives; blood sampling tubes for the preservation, storage, and transportation of blood and blood derivatives; volumetric blood collection tubes for the preservation, storage, and transportation of blood and blood derivatives; evacuated blood collection tubes for the preservation, storage, and transportation of blood and blood derivatives; blood collection containers for the preservation, storage, and transportation of blood and blood derivatives; blood collection tubes containing a composition to preserve analytes in blood and blood derivatives; blood sampling tubes containing a composition to preserve analytes in blood and blood derivatives; blood collection specimen containers containing a composition to preserve analytes in blood and blood derivatives.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
(1) Compositions for the preservation, storage, and transportation of blood and blood derivatives; compositions to preserve analytes in blood and blood derivatives.
An aqueous composition for stabilizing nucleic acid contained in a biological sample at ambient temperature is provided. The aqueous composition comprises: (i) a denaturing agent selected from sodium dodecyl sulphate (SDS) or a guanidinium salt; (ii) aurintricarboxylic acid (ATA); and (iii) at least one of a chelating agent and a buffering agent; wherein the composition has a pH of 4.9 or less. A method of stabilizing nucleic acid contained in a biological sample at ambient temperature is also provided, wherein the method comprises the steps of: a) obtaining a biological sample; b) contacting the biological sample with the above-noted aqueous composition to form a mixture; c) homogenizing the mixture of (b) to form a homogeneous mixture; and d)storing the homogeneous mixture at ambient temperature.
A biological sample collection system comprising a containment vessel and a sample collection assembly connected thereto is provided. The assembly comprises a sample collector threadedly engaged with a sample collection vessel having a sample receiving area for receiving the biological sample from the sample collector. The collector comprises a valve stem comprising a valve face, and the collection vessel comprises a complementary valve seat. The valve stem and valve seat form a valve comprising a closed configuration wherein threaded connection members of the collector and the collection vessel are fully engaged, and an open configuration wherein the threaded connection members are less than fully engaged. In the closed configuration, the valve face forms a sealing engagement with the valve seat. In the open configuration, the valve face is spaced apart from the valve seat to place the containment vessel, collection vessel, and collector in fluid communication with one another.
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
The present application is to provide a composition and method for stabilizing and maintaining the viability of hardy microorganisms from sample collection to downstream analysis. In particular, there is a method for preserving viable hardy bacteria, such as Mycobacteria, Bacillus anthracis, or Clostridium difficile, in a biological sample, comprising contacting the biological sample with a stabilization composition, wherein the stabilization composition comprises a chelating agent, a denaturing, a salt and has a p H between about 6 and about 11.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12N 1/04 - Preserving or maintaining viable microorganisms
C12Q 1/24 - Methods of sampling, or inoculating or spreading a sampleMethods of physically isolating an intact microorganism
13.
BIOLOGICAL SAMPLE COLLECTION SYSTEM WITH PUSH-ACTIVATED VALVE FOR SAMPLE RELEASE
A biological sample collection system is provided, the system comprising: a containment vessel; a sample collection reservoir disposed toward a first end of the containment vessel and comprising a valve disposed in a sample receiving area, the valve comprising: a closed configuration, wherein when the valve is in the closed configuration the biological sample is retained in the sample collection reservoir, and an open configuration, wherein when the valve is in the open configuration the biological sample is released from the sample collection reservoir into a sample storage chamber of the containment vessel; and a cap comprising a pusher; wherein, when the biological sample collection system is closed by engagement of the containment vessel with the cap, the pusher engages with the valve thereby moving the valve from the closed configuration to the open configuration to permit the biological sample to be released from the sample collection reservoir into the containment vessel.
Method and systems are provided for defining test sample read count limits for a range of microbial sequence reads. A computing device may generate a stabilization framework usable to determine a viability of a stabilization solution to stabilize a particular microbial species. The stabilization framework may include a first read count limit defined based on an enumerated abundance of the microbial species in a control sample multiplied by a first sequencing range value. The computing device may receive a read count value corresponding to an enumerated abundance of the microbial species in a mixture comprising a biological sample and the stabilization solution. The stabilization framework maybe applied to the read count value to generate an output based on whether the read count value exceeds the first read count limit. The computing device may then select, the stabilizing solution for use with subsequent biological samples.
The present invention generally relates to a sample receiving device for releasably storing a substance. The sample receiving device includes a lid having a reservoir for retaining the substance, and a pierceable barrier sealing the substance within the reservoir; and b) a funnel for receiving a sample and configured for closure by the lid. The funnel is configured for releasable attachment to a sample receptacle such that a sample can be provided to the funnel and travel through the channel in the funnel into the sample receptacle. Further, the funnel includes one or more cutting ribs for cutting the pierceable barrier such that upon cutting of the pierceable barrier the substance is released from the reservoir, flows through the channel in the funnel and into the sample receptacle to be mixed with the sample. The present invention also provides a kit for collecting and storing biomolecules.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
17.
LOW PH COMPOSITION AND METHOD FOR STABILIZING NUCLEIC ACIDS IN BIOLOGICAL SAMPLES
An aqueous composition for stabilizing nucleic acid contained in a biological sampleat ambient temperature is provided. The aqueous composition comprises: (i) adenaturing agent selected from sodium dodecyl sulphate (SDS) or a guanidinium salt;(ii) aurintricarboxylic acid (ATA); and (iii) at least one of a chelating agent and abuffering agent; wherein the composition has a pH of 4.9 or less. A method ofstabilizing nucleic acid contained in a biological sample at ambient temperature is alsoprovided, wherein the method comprises the steps of: a) obtaining a biological sample;b) contacting the biological sample with the above-noted aqueous composition to forma mixture; c) homogenizing the mixture of (b) to form a homogeneous mixture; and d)storing the homogeneous mixture at ambient temperature.
An aqueous composition for stabilizing nucleic acid contained in a biological sampleat ambient temperature is provided. The aqueous composition comprises: (i) adenaturing agent selected from sodium dodecyl sulphate (SDS) or a guanidinium salt;(ii) aurintricarboxylic acid (ATA); and (iii) at least one of a chelating agent and abuffering agent; wherein the composition has a pH of 4.9 or less. A method ofstabilizing nucleic acid contained in a biological sample at ambient temperature is alsoprovided, wherein the method comprises the steps of: a) obtaining a biological sample;b) contacting the biological sample with the above-noted aqueous composition to forma mixture; c) homogenizing the mixture of (b) to form a homogeneous mixture; and d)storing the homogeneous mixture at ambient temperature.
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
G01N 1/00 - SamplingPreparing specimens for investigation
21.
Method for collecting and preserving a biological sample
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
G01N 1/00 - SamplingPreparing specimens for investigation
22.
STABILIZING COMPOSITION AND METHOD FOR PRESERVING A BODILY FLUID
An aqueous stabilizing composition for preserving a bodily fluid at ambient temperature is provided. The aqueous stabilizing composition comprises: a sugar selected from a monosaccharide, a disaccharide, or a combination thereof; a buffering agent; a C1-C6 alkanol; boric acid, a salt of boric acid, or a combination thereof; and a chelating agent; wherein the composition has a pH of from 4.5 to 5.2. A method for preserving a bodily fluid using the aqueous stabilizing composition is also provided, the method comprising: a) obtaining a sample of the bodily fluid; b) contacting the bodily fluid with the aqueous stabilizing composition to form a mixture; c) mixing the mixture of (b) to form a homogeneous mixture; and d) storing the homogeneous mixture at ambient temperature.
A01N 1/00 - Preservation of bodies of humans or animals, or parts thereof
C12N 1/04 - Preserving or maintaining viable microorganisms
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
16 6 alkanol; boric acid, a salt of boric acid, or a combination thereof; and a chelating agent; wherein the composition has a pH of from 4.5 to 5.2. A method for preserving a bodily fluid using the aqueous stabilizing composition is also provided, the method comprising: a) obtaining a sample of the bodily fluid; b) contacting the bodily fluid with the aqueous stabilizing composition to form a mixture; c) mixing the mixture of (b) to form a homogeneous mixture; and d) storing the homogeneous mixture at ambient temperature.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
G01N 1/38 - Diluting, dispersing or mixing samples
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
A01N 1/00 - Preservation of bodies of humans or animals, or parts thereof
C12N 1/04 - Preserving or maintaining viable microorganisms
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Preservatives for optimizing the stability of biological samples and body fluid specimens during storage and transport to testing facilities; stabilizing preparations for preserving biological samples and body fluid specimens during transportation and storage to testing facilities for medical diagnostic purposes.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
(1) Preservatives for optimizing the stability of biological samples and body fluid specimens during storage and transport to testing facilities; stabilizing preparations for preserving biological samples and body fluid specimens during transportation and storage to testing facilities for medical diagnostic purposes.
26.
DEVICES, SOLUTIONS AND METHODS FOR SAMPLE COLLECTION
Some embodiments are directed to a bodily fluid sample collection device for the collection of naturally expressed bodily fluids and include a cap engageable with a tube to close a mouth of the tube. The cap includes a chamber for containing a reagent. The tube defines at least partly a sample collection space for receiving the naturally expressed bodily fluid. The cap comprises first and second cap portions relatively movable with respect to each other. The first and second cap portions are configured such that, responsive to engagement of the cap on the tube, one of the cap portions is caused to move integrally relative to the other cap portion to open the chamber and permit fluid communication between the chamber and the sample collection space. The reagent in the chamber is thereby permitted to mix with the bodily fluid in the sample collection space. A method of organizing and processing samples is also described.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
B65D 51/28 - Closures not otherwise provided for combined with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
B65D 25/56 - Inspection openings or windows with means for indicating level of contents
B65D 41/04 - Threaded or like caps or cap-like covers secured by rotation
B65D 55/02 - Locking devicesMeans for discouraging or indicating unauthorised opening or removal of closure
27.
Composition, system and method for removal of detergents from aqueous solutions
where R1 is an optionally substituted, linear, branched or cyclic C4-C12 alkyl; and a water immiscible halocarbon, wherein said halocarbon is miscible with said alcohol of Formula I. The system can be used on aqueous solutions that contain detergents (such as Sodium Dodecyl Sulphate (SDS), for example), and any detergent-associated or detergent-bound molecules that may be present in the aqueous solution, to form an aqueous phase and a non-aqueous phase, for effectively removing the detergent and any detergent-associated or detergent-bound molecules, and sequestering them into the non-aqueous phase.
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
G01N 1/00 - SamplingPreparing specimens for investigation
29.
Composition and method for stabilizing nucleic acids in biological samples
Methods, compositions, and kits for stabilizing both human and microbial deoxyribonucleic acid (DNA) present in complex biological samples, such as feces, are disclosed. In particular, aqueous compositions for stabilizing DNA contained in biological samples at ambient temperature are disclosed, together with associated methods and kits using same. In one aspect, the compositions comprise a chelating agent present at a concentration of at least about 150 mM, and the composition has a pH of at least about 9.5.
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Reagents for scientific and research purposes used to collect, stabilize, transport and prepare analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals. Reagents for clinical, medical and medical diagnostic use used to collect, stabilize, transport and prepare analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals. Scientific research, namely identification and testing of analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; scientific research and development in the field of multi-omics, including analytes (nucleic acids, proteins, metabolites) testing, purification and extraction from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; laboratory services.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific research kits for metabolites sample collection, stabilization, transportation and preparation consisting primarily of a preserving solution and specially designed collection receptacle to collect multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood. Diagnostic kits for metabolites sample collection, stabilization, transportation and preparation consisting primarily of a specifically designed collection receptacle containing a preserving solution to collect multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Genetic testing for medical, clinical, and diagnostic purposes of analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals
01 - Chemical and biological materials for industrial, scientific and agricultural use
10 - Medical apparatus and instruments
Goods & Services
Scientific research kits for metabolites sample collection, stabilization, transportation and preparation consisting primarily of a preserving solution and specially designed collection receptacle to college multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood Diagnostic kits for metabolites sample collection, stabilization, transportation and preparation consisting primarily of a specifically designed collection receptacle and also containing a preserving solution and specially designed collection receptacle to collect multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Reagents used to collect, stabilize, transport and prepare analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals all of the foregoing for scientific and research purposes Reagents used to collect, stabilize, transport and prepare analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals all of the foregoing for clinical, medical and medical diagnostic use Genetic testing for scientific and research purposes of analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; scientific and medical research and development in the field of multi-omics, including analyte (nucleic acids, proteins, metabolites) testing, purification and extraction from blood, saliva, tissue, skin urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; laboratory services for medical, scientific, and research purposes
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Reagents for scientific and research purposes used to collect, stabilize, transport and prepare analytes (namely, nucleic acids, proteins, metabolites) obtained from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals all of the foregoing for scientific and research purposes.
(2) Reagents for clinical, medical and medical diagnostic purposes used to collect, stabilize, transport and prepare analytes (namely nucleic acids, proteins, metabolites) obtained from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; Kits comprising a preserving solution and specially designed collection tube used to optimally collect, stabilize, preserve, transport and extract analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, skin, urine, feces, sputum and other bodily fluids extracted or collected from humans and animals all of the foregoing for clinical, medical and medical diagnostic use. (1) Identification and testing of analytes (nucleic acids, proteins, metabolites) from environmental samples, swabbed from surfaces, or sourced from blood, saliva, tissue, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; research and development in the field of multi-omics, including analyte (nucleic acids, proteins, metabolites) testing, purification and extraction from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals; laboratory services namely laboratory testing of materials, laboratory research services in the field of multiomics, including analyte (nucleic acids, proteins, metabolites) testing, purification and extraction from blood, saliva, tissue, skin, urine, feces, sputum, and other bodily fluids extracted or collected from humans and animals, clinical laboratory research studies, medical research laboratory services.
(2) Medical diagnostic laboratory services.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Scientific research kits for collecting, stabilizing, transporting and preparing samples for metabolite analysis which kits comprise of a preservative and specially designed collection receptacle to collect saliva, urine, feces, tissue, sputum, skin, nasal, vaginal and blood samples.
(2) Diagnostic kits for collecting, stabilizing, transporting and preparing samples for metabolite analysis which kits comprise a specifically designed collection receptacle, a preservative and specially designed collection receptacle to collect saliva, urine, feces, tissue, sputum, skin, nasal, vaginal and blood samples.
38.
CONTAINER SYSTEM FOR RELEASABLY STORING A SUBSTANCE
The present invention provides a container system for releasably storing a substance. The container system includes a vial having a sample storage chamber and a piercing member for piercing a membrane in the lid, which membrane seals a substance within a reservoir in the lid until the membrane is pierced by the piercing member. The container system optionally includes a funnel. There is also provided a method and kit for use of such a container system.
B65D 51/28 - Closures not otherwise provided for combined with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations; sanitary
preparations for medical purposes; dietetic foodstuffs and
dietetic substances adapted for medical or veterinary use;
food for babies; dietary supplements for humans and animals;
plasters, materials for dressings; material for stopping
teeth, dental wax; disinfectants; preparations for
destroying vermin; fungicides, herbicides; none of the
aforesaid goods being for diabetes care, haemophilia care,
growth hormone treatment and hormone replacement therapy. Surgical, medical, dental and veterinary apparatus and
instruments; artificial limbs, eyes and teeth; orthopedic
articles; suture materials; none of the aforesaid goods
being for diabetes care, haemophilia care, growth hormone
treatment and hormone replacement therapy. Medical services; veterinary services; hygienic and beauty
care for human beings or animals; agriculture, horticulture
and forestry services; none of the aforesaid services being
for diabetes care, haemophilia care, growth hormone
treatment and hormone replacement therapy.
43.
Stabilizing compositions and methods for extraction of ribonucleic acid
The present invention provides a composition and method for stabilizing ribonucleic acid (RNA) from biological samples such that the ribonucleic acid within the sample remains stable at room temperature. The composition comprises an anionic detergent and a buffering agent at a pH of about 5 to about 8.2 and is used in methods for extracting and storing ribonucleic acid from the biological sample.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations for medical diagnostic purposes in relation to infectious diseases and oncology; sanitary preparations for medical purposes; dietetic foodstuffs and dietetic substances in the nature of beverages adapted for medical or veterinary use; dietary supplements for humans; disinfectants; none of the aforesaid goods being for diabetes care, hemophilia care, growth hormone treatment and hormone replacement therapy Surgical apparatus and instruments; medical apparatus and instruments for medical diagnostic purposes for detecting cancer and for the analysis of body fluids in relation to infectious diseases; none of the aforesaid goods being for diabetes care, hemophilia care, growth hormone treatment and hormone replacement therapy Medical services; hygienic and beauty care for human beings; none of the aforesaid services being for diabetes care, hemophilia care, growth hormone treatment and hormone replacement therapy
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
G01N 1/00 - SamplingPreparing specimens for investigation
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary products; hygienic products
for medical use; dietetic foods and dietetic substances for
medical or veterinary use; foods for babies; food
supplements for humans and animals; plasters, bandages;
dental fillers and impression materials for dentists;
disinfectants; preparations for destroying vermin;
fungicides and herbicides. Surgical, medical, dental and veterinary apparatus and
instruments; artificial limbs, - eyes and teeth; orthopedic
articles; suture material. Medical services; veterinary services; services in the field
of hygiene and beauty care for people or animals; services
in the field of agriculture, horticulture and forestry.
47.
Devices, solutions and methods for sample collection related applications, analysis and diagnosis
A solution is described for preserving cells and/or extra-cellular components in naturally expressed bodily fluids (e.g. saliva, sputum, urine) for further downstream analysis and/or for diagnosis of a medical condition. The solution may be hypertonic with respect to blood. Techniques are described for enriching cells from a sample of a naturally expressed bodily fluid, and/or for analysis, e.g. to diagnose medical conditions such as cancer, obesity, infections, autism, Alzheimer disease, hetotological disorders, cardiovascular disease or disorders, diabetes, vulnerable plack, LTBI, HIV infection, COPD, ACQS.
The present application provides a system, composition, method and kit for removing a detergent, such as an anionicdetergent, from an aqueous solution, comprising a salt, a water immiscible alcohol of Formula I: R1 - OH (Formula I) where R1 is an optionally substituted, linear, branched or cyclic C4 - C12 alkyl; and a water immiscible halocarbon, wherein said halocarbon is miscible with said alcohol of Formula I. The system can be used on aqueous solutions that contain detergents (such as Sodium Dodecyl Sulphate (SDS), for example), and any detergent-associated or detergent-bound molecules that may be present in the aqueous solution, to form an aqueous phase and a non-aqueous phase, for effectively removing the detergent and any detergent-associated or detergent-bound molecules, and sequestering them into the non- aqueous phase. The present composition, system,method and kit may, thus, ideally be used to remove inhibitors from aqueous solutions, i.e., inhibitors that inhibit reactions such as downstream applications including, but not limited to, Polymerase Chain Reaction (PCR, including Reverse Transcriptase-PCR (RT-PCR)), library preparation, and nucleotide sequencing. The aqueous phase may then be used directly for these downstream applications.
The present application provides a system, composition, method and kit for removing a detergent, such as an anionic detergent, from an aqueous solution, comprising a salt, a water immiscible alcohol of Formula I: R1 – OH (Formula I) where R1 is an optionally substituted, linear, branched or cyclic C4 - C12 alkyl; and a water immiscible halocarbon, wherein said halocarbon is miscible with said alcohol of Formula I. The system can be used on aqueous solutions that contain detergents (such as Sodium Dodecyl Sulphate (SDS), for example), and any detergent-associated or detergent-bound molecules that may be present in the aqueous solution, to form an aqueous phase and a non-aqueous phase, for effectively removing the detergent and any detergent-associated or detergent-bound molecules, and sequestering them into the non- aqueous phase. The present composition, system, method and kit may, thus, ideally be used to remove inhibitors from aqueous solutions, i.e., inhibitors that inhibit reactions such as downstream applications including, but not limited to, Polymerase Chain Reaction (PCR, including Reverse Transcriptase-PCR (RT-PCR)), library preparation, and nucleotide sequencing. The aqueous phase may then be used directly for these downstream applications.
Clostridium difficile, in a biological sample, comprising contacting the biological sample with a stabilization composition, wherein the stabilization composition comprises a chelating agent, a denaturing, a salt and has a pH between about 6 and about 11.
C12Q 1/24 - Methods of sampling, or inoculating or spreading a sampleMethods of physically isolating an intact microorganism
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
51.
Composition and method for stabilizing nucleic acids in biological samples
Methods, compositions, and kits for stabilizing both human and microbial deoxyribonucleic acid (DNA) present in complex biological samples, such as feces, are disclosed. In particular, aqueous compositions for stabilizing DNA contained in biological samples at ambient temperature are disclosed, together with associated methods and kits using same. In one aspect, the compositions comprise a chelating agent present at a concentration of at least about 150 mM, and the composition has a pH of at least about 9.5.
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
52.
Method and system for microbial lysis using periodates
Some embodiments are directed to a bodily fluid sample collection device for the collection of naturally expressed bodily fluids and include a cap engageable with a tube to close a mouth of the tube. The cap includes a chamber for containing a reagent. The tube defines at least partly a sample collection space for receiving the naturally expressed bodily fluid. The cap comprises first and second cap portions relatively movable with respect to each other. The first and second cap portions are configured such that, responsive to engagement of the cap on the tube, one of the cap portions is caused to move integrally relative to the other cap portion to open the chamber and permit fluid communication between the chamber and the sample collection space. The reagent in the chamber is thereby permitted to mix with the bodily fluid in the sample collection space. A method of organizing and processing samples is also described.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
B65D 51/28 - Closures not otherwise provided for combined with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
B65D 25/56 - Inspection openings or windows with means for indicating level of contents
B65D 41/04 - Threaded or like caps or cap-like covers secured by rotation
B65D 55/02 - Locking devicesMeans for discouraging or indicating unauthorised opening or removal of closure
The present invention provides a composition and method for stabilizing ribonucleic acid (RNA) from biological samples such that the ribonucleic acid within the sample remains stable at room temperature. The composition comprises an anionic detergent and a buffering agent at a pH of about 5 to about 8.2 and is used in methods for extracting and storing ribonucleic acid from the biological sample.
The present application is to provide a composition and method for stabilizing and maintaining the viability of hardy microorganisms from sample collection to downstream analysis. In particular, there is a method for preserving viable hardy bacteria, such as Mycobacteria, Bacillus anthracis, or Clostridium difficile, in a biological sample, comprising contacting the biological sample with a stabilization composition, wherein the stabilization composition comprises a chelating agent, a denaturing, a salt and has a p H between about 6 and about 11.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/24 - Methods of sampling, or inoculating or spreading a sampleMethods of physically isolating an intact microorganism
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
The present application is to provide a composition and method for stabilizing and maintaining the viability of hardy microorganisms from sample collection to downstream analysis. In particular, there is a method for preserving viable hardy bacteria, such as Mycobacteria, Bacillus anthracis, or Clostridium difficile, in a biological sample, comprising contacting the biological sample with a stabilization composition, wherein the stabilization composition comprises a chelating agent, a denaturing, a salt and has a p H between about 6 and about 11.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
58.
DEVICE FOR COLLECTING, TRANSPORTING AND STORING BIOMOLECULES FROM A BIOLOGICAL SAMPLE
The present application provides a sample receiving device comprising a vial, a receptacle in communication with the vial for receiving the sample, and a cap comprising a pusher, the pusher for engaging with the sample in the receptacle. The receptacle comprises a disrupting means for disrupting the sample when the pusher engages with the sample in the receptacle and expels the disrupted sample into the vial. Typically, the device can be used for collecting fecal samples. A method of preserving a biomolecule in the device using a biomolecule preserving composition is also provided.
G01N 1/38 - Diluting, dispersing or mixing samples
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
C12M 1/24 - Apparatus for enzymology or microbiology tube or bottle type
C12M 1/28 - Inoculator or sampler being part of container
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
59.
DEVICE FOR COLLECTING, TRANSPORTING AND STORING BIOMOLECULES FROM A BIOLOGICAL SAMPLE
The present application provides a sample receiving device comprising a vial, a receptacle in communication with the vial for receiving the sample, and a cap comprising a pusher, the pusher for engaging with the sample in the receptacle. The receptacle comprises a disrupting means for disrupting the sample when the pusher engages with the sample in the receptacle and expels the disrupted sample into the vial. Typically, the device can be used for collecting fecal samples. A method of preserving a biomolecule in the device using a biomolecule preserving composition is also provided.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
C12M 1/24 - Apparatus for enzymology or microbiology tube or bottle type
C12M 1/28 - Inoculator or sampler being part of container
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
G01N 1/38 - Diluting, dispersing or mixing samples
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
The present application provides a composition comprising periodates or persulfates for extracting nucleic acid from a microorganism, and a corresponding method of using the composition for nucleic acid extraction. The composition and method are particularly useful in extracting nucleic acid from microorganisms that are generally resistant to standard nucleic extraction techniques, such as, one or more species of the Mycobacterium genus, one or more species of the M. tuberculosis complex, MDR strains of M. tuberculosis, one or more species of Clostridium, one or more species of Bacillus, and other microorganisms with hardy cell walls.
Methods, compositions, and kits for stabilizing both human and microbial deoxyribonucleic acid (DNA) present in complex biological samples, such as feces, are disclosed. In particular, aqueous compositions for stabilizing DNA contained in biological samples at ambient temperature are disclosed, together with associated methods and kits using same. In one aspect, the compositions comprise a chelating agent present at a concentration of at least about 150 m M, and the composition has a pH of at least about 9.5.
Methods, compositions, and kits for stabilizing both human and microbial deoxyribonucleic acid (DNA) present in complex biological samples, such as feces, are disclosed. In particular, aqueous compositions for stabilizing DNA contained in biological samples at ambient temperature are disclosed, together with associated methods and kits using same. In one aspect, the compositions comprise a chelating agent present at a concentration of at least about 150 m M, and the composition has a pH of at least about 9.5.
The present application provides a method and aqueous composition for stabilizing and isolating nucleic acid from whole blood or blood fraction samples. The method and aqueous composition can be used to stabilize and isolate nucleic acid from whole blood, plasma, buffy coat or total white blood cell isolates. The aqueous composition can comprise a denaturing agent, a chelating agent and a buffering agent, preferably in the absence of a chaotrope, and at a pH greater than 5.0. The samples can be stored at varying temperatures, preferably at room temperature, and for prolonged lengths of time while maintaining integrity of the nucleic acid.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic foodstuffs and dietetic substances adapted for medical or veterinary use; Food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments; Artificial limbs, eyes and teeth; Orthopedic articles; Suture materials. Medical services; Veterinary services; Hygienic and beauty care for human beings or animals; Agriculture, horticulture and forestry services.
The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 1/00 - SamplingPreparing specimens for investigation
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic foodstuffs and dietetic substances adapted for medical or veterinary use; Food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides; None of the aforesaid goods being for diabetes care, haemophilia care, growth hormone treatment and hormone replacement therapy. Surgical, medical, dental and veterinary apparatus and instruments; Artificial limbs, eyes and teeth; Orthopedic articles; Suture materials; None of the aforesaid goods being for diabetes care, haemophilia care, growth hormone treatment and hormone replacement therapy. Medical services; Veterinary services; Hygienic and beauty care for human beings or animals; Agriculture, horticulture and forestry services; None of the aforesaid services being for diabetes care, haemophilia care, growth hormone treatment and hormone replacement therapy.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Kits use to collect, preserve and transport DNA samples from subjects' saliva for identification and testing purposes comprising a preserving solution and a specially designed collection tube. Kits use to collect, preserve and transport DNA samples from subjects' saliva for identification and testing purposes comprising a preserving solution and a specially designed collection tube. Identification and testing of DNA samples sourced from saliva for the forensic and law enforcement, military, research, medical, veterinary and consumer markets.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Reagents for scientific purposes, amongst others reagents used to collect, stabilize, transport and/or prepare nucleic acids extracted from whole blood and blood derivatives. Chemical reagents for medical or veterinary purposes. Advisory services relating to chemical reagents.
A sample collection tool comprises a collection end configured for collecting a sample. Optionally, the sample is collected from within a body cavity of an animal without causing significant discomfort or injury to the animal. A first handle portion has a first end connected to the collection end and a second end. A second handle portion is connected to the second end of the first handle portion by a breakable connection. The second end of the first handle portion has at least one winglet. The at least one winglet is compliant in a preferential direction. The breakable connection is ruptured at least in part when the at least one winglet is forced in the preferential direction.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61B 10/02 - Instruments for taking cell samples or for biopsy
The present invention provides a container system for releasably storing a substance. The container system includes a vial having a sample storage chamber and a piercing member for piercing a membrane in the lid, which membrane seals a substance within a reservoir in the lid until the membrane is pierced by the piercing member. The container system optionally includes a funnel. There is also provided a method and kit for use of such a container system.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
B65D 51/28 - Closures not otherwise provided for combined with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
74.
Closure, containing apparatus, and method of using same
A closure for a container has a closure body having a first cylindrical portion and a second cylindrical portion opposite the first portion. The closure also has a connector disposed in at least one of the first and second portions. The connector is adapted to connect one of a sample collection device and an applicator to the closure. A containing apparatus including the closure, a container, and optionally one of a sample collection device and an applicator is also disclosed. A method of using the containing apparatus is also disclosed.
A sample collection tool comprises a collection end configured for collecting a sample. Optionally, the sample is collected from within a body cavity of an animal without causing significant discomfort or injury to the animal. A first handle portion has a first end connected to the collection end and a second end. A second handle portion is connected to the second end of the first handle portion by a breakable connection. The second end of the first handle portion has at least one winglet. The at least one winglet is compliant in a preferential direction. The breakable connection is ruptured at least in part when the at least one winglet is forced in the preferential direction.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
The present invention generally relates to a sample receiving device for releasably storing a substance. The sample receiving device includes a lid having a reservoir for retaining the substance, and a pierceable barrier sealing the substance within the reservoir; and b) a funnel for receiving a sample and configured for closure by the lid. The funnel is configured for releasable attachment to a sample receptacle such that a sample can be provided to the funnel and travel through the channel in the funnel into the sample receptacle. Further, the funnel includes one or more cutting ribs for cutting the pierceable barrier such that upon cutting of the pierceable barrier the substance is released from the reservoir, flows through the channel in the funnel and into the sample receptacle to be mixed with the sample. The present invention also provides a kit for collecting and storing biomolecules.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical products namely kits insofar as not included in other classes. Kits comprising a preserving solution and (specially designed) collection receptacle used to collect, stabilize, transport and prepare nucleic acids from mulitple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood. Identification, detection and testing of nucleic acid samples sourced from multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical products namely kits insofar as not included in other classes. Kits comprising one or more of a preserving solution, a sponge, and a (specially designed) collection tube used to collect, stabilize, transport and purify oral samples. Identification and testing and oral samples.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical products namely kits insofar as not included in other classes. Kits used to optimally extract and optimize nucleic acids from multiple sample types. Extraction, quantification and storage of nucleic acids from multiple sample types.
Saliva, tissue, sputum, mucus and mucosa cells, or blood collection kits comprising one or more of a specially designed collection tube, preserving solution, and a sponge, all of which are used to collect, stabilize, transport and purify said samples for medical, medical research, and diagnostic purposes
01 - Chemical and biological materials for industrial, scientific and agricultural use
10 - Medical apparatus and instruments
Goods & Services
Scientific research kits for nucleic acid sample collection, stabilization, transportation and preparation consisting primarily of a preserving solution and specially designed collection receptacle to collect multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood Diagnostic kits for nucleic acid sample collection, stabilization, transportation and preparation consisting primarily of a specifically designed collection receptacle and also containing a preserving solution and specially designed collection receptacle to collect multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Nucleic-acid extraction kits for laboratory use to optimally extract and optimize nucleic acids from multiple sample types containing one or more of the following; sample tubes, spin columns, chromatographic columns, vials, plastic bags, bottles, magnetic beads, glass beads, nucleic-acid binding beads, pipettes, reagents, buffer solution, binding buffer, elution buffer, wash buffer, lysis buffer, laboratory plasticware, laboratory glassware, and instructions Nucleic-acid extraction kits for medical diagnostic use to optimally extract and optimize nucleic acids from multiple sample types containing one or more of the following; sample tubes, spin columns, chromatographic columns, vials, plastic bags, bottles, magnetic beads, glass beads, nucleic-acid binding beads, pipettes, reagents, buffer solution, binding buffer, elution buffer, wash buffer, lysis buffer, laboratory plasticware, laboratory glassware, and instructions
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Kits comprising a preserving solution and specially designed collection receptacle used to collect, stabilize, transport and prepare nucleic acids from multiple sample types, including but not limited to saliva, urine, feces, tissue, sputum or blood.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Kits comprising one or more of a preserving solution, a sponge, and a specially designed collection tube used to collect, stabilize, transport and purify oral samples.
88.
Compositions and method for storage of nucleic acid from bodily fluids
The present invention provides an aqueous composition and method for extracting nucleic acid from a sample of bodily fluid, such as saliva, such that the nucleic acid within said sample remains stable for at least fourteen days at room temperature. The composition permits direct use of the extracted and stored DNA in an amplification reaction without further processing.
A closure for a container has a closure body having a first cylindrical portion and a second cylindrical portion opposite the first portion. The closure also has a connector disposed in at least one of the first and second portions. The connector is adapted to connect one of a sample collection device and an applicator to the closure. A containing apparatus including the closure, a container, and optionally one of a sample collection device and an applicator is also disclosed. A method of using the containing apparatus is also disclosed.
A closure for a container has a closure body having a first cylindrical portion and a second cylindrical portion opposite the first portion. The closure also has a connector disposed in at least one of the first and second portions. The connector is adapted to connect one of a sample collection device and an applicator to the closure. A containing apparatus including the closure, a container, and optionally one of a sample collection device and an applicator is also disclosed. A method of using the containing apparatus is also disclosed.
The present invention generally relates to a sample receiving device for releasably storing a substance. The samplereceiving device includes a lid having a reservoir for retaining the substance, and a pierceable barrier sealing the substance withinthe reservoir; and b) a funnel for receiving a sample and configured for closure by the lid. The funnel is configured for releasableattachment to a sample receptacle such that a sample can be provided to the funnel and travel through the channel in the funnelinto the sample receptacle. Further, the funnel includes one or more cutting ribs for cutting the pierceable barrier such that uponcutting of the pierceable barrier the substance is released from the reservoir, flows through the channel in the funnel and into thesample receptacle to be mixed with the sample. The present invention also provides a kit for collecting and storing biomolecules.
The present invention generally relates to a sample receiving device for releasably storing a substance. The sample receiving device includes a lid having a reservoir for retaining the substance, and a pierceable barrier sealing the substance within the reservoir; and b) a funnel for receiving a sample and configured for closure by the lid. The funnel is configured for releasable attachment to a sample receptacle such that a sample can be provided to the funnel and travel through the channel in the funnel into the sample receptacle. Further, the funnel includes one or more cutting ribs for cutting the pierceable barrier such that upon cutting of the pierceable barrier the substance is released from the reservoir, flows through the channel in the funnel and into the sample receptacle to be mixed with the sample. The present invention also provides a kit for collecting and storing biomolecules.
The present invention provides a container system for releasably storing a substance. The container system includes a vial having a sample storage chamber and a piercing member for piercing a membrane in the lid, which membrane seals a substance within a reservoir in the lid until the membrane is pierced by the piercing member. The container system optionally includes a funnel. There is also provided a method and kit for use of such a container system.
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
An aqueous composition comprising a denaturing agent, a chelator, a buffering agent and a protease for the extraction of nucleic acid from a sample of bodily fluid, such as saliva, such that the extracted nucleic acid is stable for at least fourteen days at room temperature and can be directly utilized in an amplification reaction without further processing. In particular, said composition comprises SDS, Cyclohexanediamine tetraacetate, Tris-HCl and proteinase K. A method and kit for the amplification of DNA directly from a bodily fluid, comprising said composition, is further provided.
The present invention provides a composition and method for stabilizing ribonucleic acid (RNA) from biological samples such that the ribonucleic acid within the sample remains stable at room temperature. The composition comprises an anionic detergent and a buffering agent at a pH of about 5 to about 8.2 and is used in methods for extracting and storing ribonucleic acid from the biological sample.
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
The present invention provides a container system for releasably storing a substance. The container system includes a vial having a sample storage chamber and a piercing member for piercing a membrane in the lid, which membrane seals a substance within a reservoir in the lid until the membrane is pierced by the piercing member. The container system optionally includes a funnel. There is also provided a method and kit for use of such a container system.
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
B65D 47/36 - Closures with frangible parts adapted to be pierced, torn or removed, to provide discharge openings
B65D 81/32 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
97.
CONTAINER SYSTEM FOR RELEASABLY STORING A SUBSTANCE
The present invention provides a container system for releasably storing a substance. The container system includes a vial having a sample storage chamber and a piercing member for piercing a membrane in the lid, which membrane seals a substance within a reservoir in the lid until the membrane is pierced by the piercing member. The container system optionally includes a funnel. There is also provided a method and kit for use of such a container system.
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
B65D 47/36 - Closures with frangible parts adapted to be pierced, torn or removed, to provide discharge openings
B65D 81/32 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
98.
COMPOSITIONS AND METHOD FOR STORAGE OF NUCLEIC ACID FROM BODILY FLUIDS
An aqueous composition comprising a denaturing agent, a chelator, a buffering agent and a protease for the extraction of nucleic acid from a sample of bodily fluid, such as saliva, such that the extracted nucleic acid is stable for at least fourteen days at room temperature and can be directly utilised in an amplification reaction without further processing. In particular, said composition comprises SDS, Cyclohexanediamine tetraacetate, Tris-HCl and proteinase K. A method and kit for the amplification of DNA directly from a bodily fluid, comprising said composition, is further provided.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Kits used to collect, preserve and transport DNA samples from subjects' saliva for scientific/forensic identification and testing purposes consisting of specially designed collection tube containers and a preserving solution Kits used to collect, preserve and transport DNA samples from subjects' saliva for medical identification and testing purposes consisting of specially designed collection tube containers and a preserving solution
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Kits use to collect, preserve and transport DNA samples from subjects' saliva for identification and testing purposes comprising a preserving solution and a specially designed collection tube. (1) Identification and testing of DNA samples sourced from saliva for the forensic and law enforcement, military, research, and consumer markets.
(2) Identification and testing of DNA samples sourced from saliva for the medical and veterinary markets.
