Diverchim

France

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IPC Class
A61K 8/42 - Amides 2
C07D 209/20 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane 2
A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides 1
A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon 1
A61K 8/33 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen 1
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Found results for  patents

1.

CYCLOPROPYLBORONIC COMPOUNDS, METHOD FOR PREPARING SAME AND USE THEREOF

      
Application Number FR2013053057
Publication Number 2014/091167
Status In Force
Filing Date 2013-12-12
Publication Date 2014-06-19
Owner DIVERCHIM (France)
Inventor
  • Oosting, Peter
  • Thomas, Emmanuel
  • Pamuk, Rukiye
  • Folleas, Benoit
  • Brayer, Jean-Louis
  • De Carne Carnavalet, Benoït
  • Meyer, Christophe
  • Cossy, Janine

Abstract

The present invention relates to cyclopropylboronic compounds, to the method for preparing same and to the use thereof.

IPC Classes  ?

  • C07D 213/85 - Nitriles in position 3
  • C07D 215/14 - Radicals substituted by oxygen atoms
  • C07D 217/16 - Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
  • C07D 317/46 - Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
  • C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
  • C07D 333/16 - Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
  • C07D 239/26 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
  • C07F 5/02 - Boron compounds
  • C07D 213/55 - AcidsEsters
  • C07D 213/61 - Halogen atoms or nitro radicals
  • C07D 307/46 - Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
  • C07D 307/79 - Benzo [b] furansHydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
  • C07C 67/30 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
  • C07C 69/743 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of acids with a three-membered ring and with unsaturation outside the ring
  • C07C 69/75 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of acids with a six-membered ring
  • C07C 69/757 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety

2.

METHOD FOR PRODUCING CHIRAL PEPTIDES

      
Application Number FR2013051327
Publication Number 2013/190212
Status In Force
Filing Date 2013-06-07
Publication Date 2013-12-27
Owner DIVERCHIM (France)
Inventor
  • Brayer, Jean-Louis
  • Folleas, Benoit
  • Palais, Laetitia

Abstract

The invention relates to a method for producing chiral peptides using a solvent and a proton donor element, the pKa in water of which is higher than 7, in the presence of a base pertaining to an acid-base pair, the pKa in water of which is higher than 4, said chiral peptides comprising at least one α-or β-amino acid, or at least one derivative of an α- or β-amino acid, with an enantiomer excess of at least 90% or a diastereoisomer excess of at least 85%, by reacting a starting product consisting of an α-aminoacrylate or an α-aminoacrylamide with an organometallic derivative or an organoboron derivative, particularly with a boron derivative, by means of a chiral phosphorus ligand depleted of electrons, in the presence of a catalyst containing a transition metal, at a temperature varying between 10°C and 80°C, the chiral compounds consisting of an α- or β-amino acid -the amino group of which is non-substituted or of a derivative of an α- or β-amino acid, said derivative being an α- or β-amino acid of which one of the two carboxylic acid and amino acid groups of the main chain is protected by a protecting group, the other being non-substituted or also protected by a protecting group - being excluded.

IPC Classes  ?

  • C07D 209/20 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
  • C07D 317/60 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07C 237/22 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

3.

NOVEL ANTI-AGING AND DEPIGMENTING COSMETIC COMPOSITIONS

      
Application Number FR2012052964
Publication Number 2013/093320
Status In Force
Filing Date 2012-12-18
Publication Date 2013-06-27
Owner DIVERCHIM (France)
Inventor
  • Frison, Natacha
  • Folleas, Benoit
  • Brayer, Jean-Louis
  • Wafflart, Florence

Abstract

The invention relates to the use of 1-aryl-2-aryloxyethane compounds with formula I, wherein n and m are equal to 0 or 1, provided that n+m=1, R1 and R2 particularly representing hydrogen atoms, R3 and R4 particularly representing hydrogen or halogen atoms or hydroxy or alkoxy groups, and R5 particularly representing hydrogen atoms or hydroxy, alkyl, alkoxy, amino or nitro groups, in cosmetic compositions intended for anti-aging and/or depigmenting and/or anti-inflammatory and/or healing care products.

IPC Classes  ?

  • C07D 249/08 - 1,2,4-TriazolesHydrogenated 1,2,4-triazoles
  • A61K 8/33 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
  • C07C 49/786 - Benzophenone
  • C07C 233/11 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
  • C07D 309/10 - Oxygen atoms
  • C07D 207/325 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
  • C07D 321/00 - Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups
  • C07H 15/203 - Monocyclic carbocyclic rings other than cyclohexane ringsBicyclic carbocyclic ring systems
  • A61K 8/42 - Amides
  • A61K 8/46 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
  • A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K 8/60 - SugarsDerivatives thereof
  • A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
  • A61Q 19/08 - Anti-ageing preparations

4.

NOVEL CERAMIDE ANALOGUES, PROCESSES FOR PREPARING SAME AND USES THEREOF

      
Application Number FR2012051592
Publication Number 2013/014354
Status In Force
Filing Date 2012-07-05
Publication Date 2013-01-31
Owner DIVERCHIM (France)
Inventor
  • Brayer, Jean-Louis
  • Frison, Natacha
  • Folleas, Benoit

Abstract

The invention relates to ceramide-analogue compounds which have a cyclic structure derived from cyclopropane, from cyclobutane or from cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is linked to the ring via the nitrogen atom of said function and bears a hydrocarbon-based chain originating from a fatty acid. The amide functions may be cis or trans with respect to one another. The invention also relates to the processes for preparing these novel compounds and also to pharmaceutical and/or cosmetic compositions containing same.

IPC Classes  ?

  • C07C 231/02 - Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
  • C07C 233/41 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
  • C07C 235/28 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
  • C07C 237/16 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
  • C07C 271/22 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
  • C07D 309/12 - Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
  • C07F 7/18 - Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
  • C07F 9/40 - Esters thereof
  • A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
  • A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
  • A61K 8/42 - Amides
  • A61K 8/55 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing phosphorus

5.

PROCESSES FOR PREPARING PHOSPHORUS-CONTAINING Α- AND Β-AMINO ACIDS AND DERIVATIVES THEREOF

      
Application Number FR2012051228
Publication Number 2012/175837
Status In Force
Filing Date 2012-05-31
Publication Date 2012-12-27
Owner DIVERCHIM (France)
Inventor
  • Darses, Sylvain
  • Folleas, Benoit
  • Brayer, Jean-Louis
  • Lefevre, Nicolas

Abstract

The subject of the invention is the use of an organometallic compound for the implementation of a process for preparing chiral derivatives consisting of phospho α- or β-amino acids and also derivatives thereof with enantiomeric excesses of at least 50%, by reacting a starting product consisting of an α- or β-dehydroamino phosphoester with an organometallic compound, in the presence of a catalyst containing a transition metal and a chiral ligand, at a temperature that varies from -20°C to 90°C.

IPC Classes  ?

6.

PROCESS FOR PREPARING CHIRAL AMINO ACIDS

      
Application Number FR2011053147
Publication Number 2012/085474
Status In Force
Filing Date 2011-12-22
Publication Date 2012-06-28
Owner DIVERCHIM (France)
Inventor
  • Darses, Sylvain
  • Lefevre, Nicolas
  • Folleas, Benoit
  • Brayer, Jean-Louis

Abstract

The present invention relates to a process for preparing chiral amino acids with excellent enantiomeric excesses.

IPC Classes  ?

  • C07C 269/06 - Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
  • C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
  • C07D 209/20 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
  • C07D 307/54 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07D 307/91 - DibenzofuransHydrogenated dibenzofurans
  • C07D 317/60 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07D 333/24 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07D 333/60 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07C 317/50 - SulfonesSulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups X being a hetero atom, Y being any atom
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07F 7/08 - Compounds having one or more C—Si linkages