Abstract

The present invention relates to a dental composition comprising at least one polymerization shrinkage mediator. More particularly, the present invention relates to a dental composition comprising at least one polymerizable monomer, at least one polymerization initiator and at least one polymerization shrinkage mediator, wherein the at least one polymerization shrinkage mediator is ethyl 2-phenylacrylate. The present invention also releates to a dental composition comprising the phenylacrylate in a high purity. The dental composition is for production of a dental restoration material, a dental adhesive, a dental cement, a post and core material, an endo-crown material or a pontic in fixed partial dentures. The dental composition is for medical applications.

IPC Classes  ?

• A61K 6/62 - Photochemical radical initiators
• A61K 6/76 - Fillers comprising silicon-containing compounds
• A61K 6/77 - Glass
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

IPC Classes  ?

• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/61 - Cationic, anionic or redox initiators
• A61K 6/62 - Photochemical radical initiators
• A61K 6/77 - Glass
• A61K 6/78 - Pigments
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to a process for producing a composite material with reduced porosity by applying a vacuum to the mixing container before actual mixing steps. The composite material comprises a monomer mixture and a glass filler or a blend of glass fillers. The monomer mixture comprises at least one polymerizable monomer, a polymerization initiator and a polymerization stabilizer. Optionally, the composite material may comprise at least one pigment. The porosity of the composite material was determined and the porosity was compared with the porosity of the composite material produced by a process wherein a vacuum was not applied before all of the mixing steps. The preferred mixing container of the processes of the present invention is a planetary mixer or a centrifugal mixer. The composite material is for use in the dental industry.

IPC Classes  ?

• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/61 - Cationic, anionic or redox initiators
• A61K 6/62 - Photochemical radical initiators
• A61K 6/77 - Glass
• A61K 6/78 - Pigments
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention is related to a dental composition comprising at least one polymerizable monomer having at least one ethylenically unsaturated group; and a radical initiator system comprising a photosensitizer having an absorption maximum ranging from 400 nm to 800 nm; and at least one thiophenium compound as coinitiator.

IPC Classes  ?

• A61K 6/62 - Photochemical radical initiators
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention is related to a dental composition comprising at least one polymerizable monomer having at least one ethylenically unsaturated group; and a radical initiator system comprising a photosensitizer having an absorption maximum ranging from 400 nm to 800 nm; and at least one thiophenium compound as coinitiator.

IPC Classes  ?

• A61K 6/62 - Photochemical radical initiators
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention is related to a dental root canal filling composition comprising at least one di- or polyepoxide; at least one primary monoamine; and at least one diamine; wherein the at least one primary monoamine comprises at least one cyclic non-aromatic hydrocarbon group and at least one primary amino group; wherein said at least one primary amino group is directly attached to said at least one cyclic non-aromatic hydrocarbon group; or wherein said at least one primary amino group is comprised by a hydrocarbon moiety, which is directly attached to said at least one cyclic non-aromatic hydrocarbon group.

IPC Classes  ?

• A61K 6/54 - FillingSealing
• A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Abstract

The present invention is related to a dental root canal filling composition comprising at least one di- or polyepoxide; at least one primary monoamine; and at least one diamine; wherein the at least one primary monoamine comprises at least one cyclic non-aromatic hydrocarbon group and at least one primary amino group; wherein said at least one primary amino group is directly attached to said at least one cyclic non-aromatic hydrocarbon group; or wherein said at least one primary amino group is comprised by a hydrocarbon moiety, which is directly attached to said at least one cyclic non-aromatic hydrocarbon group.

IPC Classes  ?

• A61K 6/54 - FillingSealing
• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives

Abstract

The present invention is related to a dental resin modified glass-ionomer composition comprising (a) water; (b) at least one polycarboxylic acid; (c) at least one compound having at least one phosphorous atom; and (d) at least one bisacrylamide having formula (I). The present invention is further related to a kit comprising such a dental resin modified glass-ionomer composition.

IPC Classes  ?

• A61K 6/61 - Cationic, anionic or redox initiators
• A61K 6/71 - Fillers
• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements

Abstract

The present invention is related to a dental resin modified glass-ionomer composition comprising (a) water; (b) at least one polycarboxylic acid; (c) at least one compound having at least one phosphorous atom; and (d) at least one bisacrylamide having formula (I). The present invention is further related to a kit comprising such a dental resin modified glass-ionomer composition.

IPC Classes  ?

• A61K 6/71 - Fillers
• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements

Abstract

The present invention is related to a dental composition comprising: (a) at least one polymerizable monomer having at least one ethylenically unsaturated group; (b) a radical initiator system comprising (i) a photosensitizer having an absorption maximum ranging from 400 nm to 800 nm; (ii) a coinitiator; and (iii) a compound of the following formula (I), wherein R1and R21-61-61-6 alkoxy group; R3and R41-61-6 alkyl group, or R3and R4may represent a bond so that the carbon atoms to which R3and R4are bonded are linked by a double bond; R5and R61-61-6 alkyl group, or R5and R6may represent a bond so that the carbon atoms to which R5and R61-61-61-6 alkoxy group; n and m, independently are integers of 1 to 6.

IPC Classes  ?

• A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/40 - Primers
• A61K 6/54 - FillingSealing
• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives
• A61K 6/62 - Photochemical radical initiators
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention is related to a dental composition comprising: (a) at least one polymerizable monomer having at least one ethylenically unsaturated group; (b) a radical initiator system comprising (i) a photosensitizer having an absorption maximum ranging from 400 nm to 800 nm; (ii) a coinitiator; and (iii) a compound of the following formula (I), wherein R1 and R2, which may be the same or different, independently represent a hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R3 and R4, which may be the same or different, independently represent a hydrogen atom, or a C1-6 alkyl group, or R3 and R4 may represent a bond so that the carbon atoms to which R3 and R4 are bonded are linked by a double bond; R5 and R6, which may be the same or different, independently represent a hydrogen atom, or a C1-6 alkyl group, or R5 and R6 may represent a bond so that the carbon atoms to which R5 and R6 are bonded are linked by a double bond; L represents a single bond or a group -CRH-, wherein R may be a hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; n and m, independently are integers of 1 to 6.

IPC Classes  ?

• A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/40 - Primers
• A61K 6/54 - FillingSealing
• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives
• A61K 6/62 - Photochemical radical initiators
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention is related to a dental composition comprising at least one polymerizable monomer having at least one ethylenically unsaturated group; and a radical initiator system comprising a photosensitizer having an absorption maximum ranging from 400 nm to 800 nm; and at least one CH-acidic compound as coinitiator.

IPC Classes  ?

• A61K 6/62 - Photochemical radical initiators
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention is related to a dental composition comprising at least one polymerizable monomer having at least one ethylenically unsaturated group; and a radical initiator system comprising a photosensitizer having an absorption maximum ranging from 400 nm to 800 nm; and at least one CH-acidic compound as coinitiator.

IPC Classes  ?

• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/54 - FillingSealing
• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives
• A61K 6/62 - Photochemical radical initiators

Abstract

A redox curing dental composition comprising: (a) one or more compounds having a radical polymerizable carbon-carbon double bond; (b) a redox initiator system comprising (i) a reducing agent which is a compound of the following formula (I): wherein R1and R21-181-18 hydrocarbyl group, or R1and R2form together with the silicon atom to which they are bonded a 3 to 8-membered silicon-containing alicyclic ring, which groups R1and/or R21-61-6 alkoxy group, a halogen atom, or a carboxylic acid group; and (ii) an oxidizing agent adapted to oxidize the reducing agent of formula (I) in the absence of light for generating a radical capable of initiating radical polymerization of the one or more compounds having a radical polymerizable carbon-carbon double bond.

IPC Classes  ?

• A61K 6/54 - FillingSealing
• C08F 4/40 - Redox systems
• A61K 6/61 - Cationic, anionic or redox initiators
• A61K 6/62 - Photochemical radical initiators
• A61K 6/69 - Medicaments

Abstract

A redox curing dental composition comprising: (a) one or more compounds having a radical polymerizable carbon-carbon double bond; (b) a redox initiator system comprising (i) a reducing agent which is a compound of the following formula (I): wherein R1 and R2 which may be the same or different, independently represent a C1-18 hydrocarbyl group, or R1 and R2 form together with the silicon atom to which they are bonded a 3 to 8-membered silicon-containing alicyclic ring, which groups R1 and/or R2 may be substituted with one to three substituents selected from the group consisting of a C1-6 alkoxy group, a halogen atom, or a carboxylic acid group; and (ii) an oxidizing agent adapted to oxidize the reducing agent of formula (I) in the absence of light for generating a radical capable of initiating radical polymerization of the one or more compounds having a radical polymerizable carbon-carbon double bond.

IPC Classes  ?

• A61K 6/54 - FillingSealing
• A61K 6/61 - Cationic, anionic or redox initiators
• A61K 6/62 - Photochemical radical initiators
• A61K 6/69 - Medicaments
• C08F 4/40 - Redox systems

Abstract

Dental composition comprising (i) one or more di- or polyepoxides; (ii) a compound of the following formula (I).

IPC Classes  ?

• A61K 6/54 - FillingSealing
• A61K 6/69 - Medicaments
• A61K 6/78 - Pigments

Abstract

Dental composition comprising (i) one or more di- or polyepoxides; (ii) a compound of the following formula (I).

IPC Classes  ?

• A61K 6/54 - FillingSealing
• A61K 6/69 - Medicaments
• A61K 6/78 - Pigments

Abstract

Dental root canal filling composition comprising (a) one or more diepoxides; (b) one or more primary monoamines and/or disecondary diamines; (c) a particulate filler, wherein the one or more diepoxides are selected from compounds of the following formula (I) or a salt thereof.

IPC Classes  ?

• A61K 6/54 - FillingSealing
• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives
• A61K 6/891 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• C07D 303/26 - Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds having one or more free hydroxyl radicals
• C07D 303/28 - Ethers with hydroxy compounds containing oxirane rings
• C08G 59/06 - Polycondensates containing more than one epoxy group per molecule of polyhydroxy compounds with epihalohydrins or precursors thereof of polyhydric phenols
• C08G 59/28 - Di-epoxy compounds containing acyclic nitrogen atoms
• C08G 59/50 - Amines
• C08L 63/00 - Compositions of epoxy resinsCompositions of derivatives of epoxy resins

Abstract

Dental root canal filling composition comprising (a) one or more diepoxides; (b) one or more primary monoamines and/or disecondary diamines; (c) a particulate filler, wherein the one or more diepoxides are selected from compounds of the following formula (I) or a salt thereof.

IPC Classes  ?

• C07D 303/26 - Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds having one or more free hydroxyl radicals
• C08G 59/28 - Di-epoxy compounds containing acyclic nitrogen atoms
• C08G 59/50 - Amines
• C08L 63/00 - Compositions of epoxy resinsCompositions of derivatives of epoxy resins
• C08G 59/06 - Polycondensates containing more than one epoxy group per molecule of polyhydroxy compounds with epihalohydrins or precursors thereof of polyhydric phenols
• A61K 6/54 - FillingSealing
• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives
• A61K 6/891 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• C07D 303/28 - Ethers with hydroxy compounds containing oxirane rings

Abstract

Described herein is a dental composition containing a polymerizable compound having at least one optionally derivatized ß-hydroxy urethane unit. The polymerizable compound having at least one optionally derivatized ß-hydroxy urethane unit is obtained without use of organo-metal catalysts and isocyanates and by a reaction between an at least one component A having at least one cyclic carbonate group with an at least one component B having at least one of primary amine functional group and secondary amine functional group. The present disclosure relates to use of the polymerizable compound having at least one optionally derivatized ß-hydroxy urethane unit for the preparation of a dental composition, in particular a dental composite, a glass ionomer, a dental cement, a dental sealant, and a dental adhesive.

IPC Classes  ?

• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements
• A61K 6/893 - Polyurethanes
• C07C 269/04 - Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
• C08G 71/04 - Polyurethanes
• C09J 175/04 - Polyurethanes

Abstract

Described herein is a dental composition containing a polymerizable compound having at least one optionally derivatized β-hydroxy urethane unit. The polymerizable compound having at least one optionally derivatized β-hydroxy urethane unit is obtained without use of organo-metal catalysts and isocyanates and by a reaction between an at least one component A having at least one cyclic carbonate group with an at least one component B having at least one of primary amine functional group and secondary amine functional group. The present disclosure relates to use of the polymerizable compound having at least one optionally derivatized β-hydroxy urethane unit for the preparation of a dental composition, in particular a dental composite, a glass ionomer, a dental cement, a dental sealant, and a dental adhesive.

IPC Classes  ?

• C08G 71/04 - Polyurethanes
• C07C 269/04 - Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements
• A61K 6/893 - Polyurethanes
• C09J 175/04 - Polyurethanes

Abstract

3,99min,3,99min3993,50 3,50 of the glassflakes is larger than the thickness of the glassflakes.

IPC Classes  ?

• A61C 13/00 - Dental prosthesesMaking same

Abstract

An additive manufacturing process comprising: (a) providing a curable composition comprising: (i) a filler comprising glassflakes having a diameter D3,99 as determined by light scattering in the range of from 5 to 150 µm; and (ii) one or more curable compounds; (b) controlling an apparatus to form an object by using the curable composition, whereby the curable composition passes a discharge orifice having a minimum diameter Fmin, wherein the ratio of the minimum diameter of the discharge orifice to the diameter D3,99 of the glassflakes (Fmin/D3,99) is in the range of 2 to less than 10; and wherein the median diameter D3,50 of the glassflakes is larger than the thickness of the glassflakes.

IPC Classes  ?

• A61C 13/00 - Dental prosthesesMaking same

Abstract

The present invention relates to the preparation of dental compositions such as dental bonding agents, dental sealers, dental composites, resin-modified dental cements, and dental impression materials. In an embodiment, the present invention provides a dental composition comprising (a) a polymerizable monomer, and (b) a specific polymerization initiator system containing a combination of a light-absorbing sensitizer or an oxidizing agent and a specific coinitiator of formula (I): Q-X where Q and X are as defined herein. The compound of formula (I) acts as a chain extender or is integrated as a crosslinking site into the polymer network during the curing reaction of the dental composition so that leaching of an aromatic amine is reduced or excluded while at the same time a high polymerization efficiency and storage stability are provided.

IPC Classes  ?

• A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• A61K 6/61 - Cationic, anionic or redox initiators
• A61K 6/79 - Initiators
• A61K 6/884 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
• A61K 6/90 - Compositions for taking dental impressions

Abstract

A dental composition comprising (a) a polymerizable monomer; and (b) an initiator system comprising (b-1) a sensitizer or an oxidizing agent of a redox initiator system; and (b-2) a coinitiator of the following formula (I): Q-X (I) wherein Q and X are as defined in claim 1.

IPC Classes  ?

• A61K 6/00 - Preparations for dentistry
• A61K 6/79 - Initiators

Abstract

The present invention is related to a curable dental two-pack composition comprising: (a) a first paste comprising (a-1) one or more crosslinker having at least four primary amino groups; and (b) a second paste comprising (b-1) one or more compounds polymerizable with a crosslinker of the first paste in a step-growth polymerization reaction; wherein (b-1) the compound polymerizable with the crosslinker compounds is a compound of formula (II), wherein A is a hydrocarbon group which may contain one or more hetero atoms selected from oxygen and sulfur atoms; R1 is a hydrogen atom or a C1_6 alkyl group; R4, R5, R6 and R7 are independent from each other and represent a hydrogen atom or a methyl group and the Y, which are independent from each other represent a single bond, an oxygen atom, a sulfur atom, an ester bond or a urethane bond.

IPC Classes  ?

• A61K 6/00 - Preparations for dentistry
• A61K 6/54 - FillingSealing
• A61K 6/891 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention is related to a curable dental two-pack composition comprising: (a) a first paste comprising (a-1) one or more crosslinker having at least four primary amino groups; and (b) a second paste comprising (b-1) one or more compounds polymerizable with a crosslinker of the first paste in a step-growth polymerization reaction; wherein (b-1) the compound polymerizable with the crosslinker compounds is a compound of the following formula (II): wherein A is a hydrocarbon group which may contain one or more hetero atoms selected from oxygen and sulfur atoms; R1is as defined in claim 1; R4, R5, R6and R7 are independent from each other and represent a hydrogen atom or a methyl group and the Y, which are independent from each other represent a single bond, an oxygen atom, a sulfur atom, an ester bond or a urethane bond.

IPC Classes  ?

• A61K 6/891 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry
• A61K 6/54 - FillingSealing

Abstract

A photocurable dental impression material comprising: (a) a mixture of polymerizable silicone compounds each having two or more polymerizable (meth)acrylate groups, said mixture having a dynamic viscosity at 25°C of from 1 to 100 Pas; (b) a filler; (c) a photo initiator system, wherein the mixture of polymerizable silicone compounds comprises based on the total weight of the mixture of polymerizable silicone compounds (a) 10 to 90 percent by weight of high-molecular polymerizable silicone compounds having a molecular weight in the range of from more than 4000 up to 10.000; and (b) 90 to 10 percent by weight of polymerizable silicone compounds having a molecular weight in the range of from 300 to 4000.

IPC Classes  ?

• A61K 6/90 - Compositions for taking dental impressions
• C08F 290/06 - Polymers provided for in subclass

Abstract

The present invention relates to a dental composition comprising a radically polymerizable compound, a redox initiator system comprising one or more clathrate compounds comprising a host molecule and one or more guest molecules, wherein the host molecule is selected from cyclodextrines, crown ethers, cucurbituriles and calixarenes and the one or more guest molecules are reducing agents, and an oxidizing agent. Furthermore, the present invention relates to a use of the redox initiator system in a dental composition.

IPC Classes  ?

• A61K 6/61 - Cationic, anionic or redox initiators
• A61K 6/884 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins

Abstract

The present invention relates to a dental composition comprising a radically polymerizable compound, a redox initiator system comprising one or more clathrate compounds comprising a host molecule and one or more guest molecules, wherein the host molecule is selected from cyclodextrines, crown ethers, cucurbituriles and calixarenes and the one or more guest molecules are reducing agents, and an oxidizing agent. Furthermore, the present invention relates to a use of the redox initiator system in a dental composition.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

A photocurable dental impression material comprising: (a) a mixture of polymerizable silicone compounds each having two or more polymerizable (meth)acrylate groups, said mixture having a dynamic viscosity at 25°C of from 1 to 100 Pas; (b) a filler; (c) a photo initiator system, wherein the mixture of polymerizable silicone compounds comprises based on the total weight of the mixture of polymerizable silicone compounds (a) 10 to 90 percent by weight of high-molecular polymerizable silicone compounds having a molecular weight in the range of from more than 4000 up to 10.000; and (b) 90 to 10 percent by weight of polymerizable silicone compounds having a molecular weight in the range of from 300 to 4000.

IPC Classes  ?

• A61K 6/10 - Compositions for taking dental impressions
• A61K 6/093 - Polyorganosilicon compounds

Abstract

A curable dental impression material comprising: (a) one or more siloxane compounds having two or more epoxide groups; (b) a photo initiator for initiating cationic polymerization of epoxide groups of the one or more siloxane compounds; and (c) a filler.

IPC Classes  ?

• A61K 6/10 - Compositions for taking dental impressions
• A61K 6/087 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to a photocurable dental composition comprising a specific polymerization initiator system containing the combination of a photoinitiator compound and a coinitiator compound being a sulfinate compound or a sulfonate compound. The present invention also relates to the use of this polymerization initiator system in a photocurable dental composition.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry
• A61K 6/10 - Compositions for taking dental impressions

Abstract

The present invention relates to a dental impression material adapted to be cured by visible light, comprising a compound having one or more aliphatic unsaturated groups, a compound containing at least one silicon-bonded hydrogen atom and not having more than three hydrogen atoms attached to any one silicon atom, a photoactivatable catalyst component, and a specific initiator component.

IPC Classes  ?

• A61K 6/90 - Compositions for taking dental impressions
• C08G 77/20 - Polysiloxanes containing silicon bound to unsaturated aliphatic groups
• C08G 77/442 - Block- or graft-polymers containing polysiloxane sequences containing vinyl polymer sequences

Abstract

The present invention relates to a photocurable dental composition comprising a specific polymerization initiator system containing the combination of a photoinitiator compound and a coinitiator compound being a sulfinate compound or a sulfonate compound. The present invention also relates to the use of this polymerization initiator system in a photocurable dental composition.

IPC Classes  ?

• A61K 6/62 - Photochemical radical initiators
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements
• A61K 6/90 - Compositions for taking dental impressions

Abstract

The present invention relates to a photocurable dental composition comprising a specific polymerization initiator system containing the combination of a photoinitiator compound and a coinitiator compound being a sulfinate compound or a sulfonate compound. The present invention also relates to the use of this polymerization initiator system in a photocurable dental composition.

IPC Classes  ?

• A61K 6/62 - Photochemical radical initiators
• A61K 6/884 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins

Abstract

The present invention relates to a dental impression material adapted to be cured by visible light, comprising a compound having one or more aliphatic unsaturated groups, a compound containing at least one silicon-bonded hydrogen atom and not having more than three hydrogen atoms attached to any one silicon atom, a photoactivatable catalyst component, and a specific initiator component.

IPC Classes  ?

• A61K 6/10 - Compositions for taking dental impressions

Abstract

The present invention relates to a dental composition comprising a photoinitiator system comprising a particulate carrier supporting a coinitiator covalently bonded to the surface of the carrier. Furthermore, the present invention relates to a use of the particulate carrier in a dental composition. The particulate carrier displays multiple covalently bonded tertiary amino groups and/or tertiary phosphine groups on the surface, for crosslinking monomers, oligomers and/or polymers having one or more polymerizable double bonds.

IPC Classes  ?

• A61K 6/00 - Preparations for dentistry
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to a dental composition comprising a photoinitiator system comprising a particulate carrier supporting a coinitiator covalently bonded to the surface of the carrier. Furthermore, the present invention relates to a use of the particulate carrier in a dental composition. The particulate carrier displays multiple covalently bonded tertiary amino groups and/or tertiary phosphine groups on the surface, for crosslinking monomers, oligomers and/or polymers having one or more polymerizable double bonds.

IPC Classes  ?

• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives
• A61K 6/70 - Preparations for dentistry comprising inorganic additives
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to an initiator modified polyacidic polymer having a covalently bonded initiator compound, and to a dental resin-modified glass ionomer composition comprising this polyacidic polymer, Furthermore, the present invention relates to a use of the initiator modified polyacidic polymer for the preparation of a dental composition. The covalently bonded initiator compound of the initiator modified polyacidic polymer may be any compound of a redox initiator system, a photoinitiator system, for example a Norrish type I or II photoinitiator, an electron donor component, a sensitizer component or a coinitiator component.

IPC Classes  ?

• A61K 6/62 - Photochemical radical initiators
• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements

Abstract

The present invention relates to an initiator modified polyacidic polymer having a covalently bonded initiator compound, and to a dental resin-modified glass ionomer composition comprising this polyacidic polymer, Furthermore, the present invention relates to a use of the initiator modified polyacidic polymer for the preparation of a dental composition. The covalently bonded initiator compound of the initiator modified polyacidic polymer may be any compound of a redox initiator system, a photoinitiator system, for example a Norrish type I or II photoinitiator, an electron donor component, a sensitizer component or a coinitiator component.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention relates to a dental composition comprising (i) a polymerizable composition containing a compound having repeating units of the following formula (I), wherein R1 represents a hydrogen atom or a linear C1-6 alkyl group, or a branched or cyclic C3-6 alkyl group; L represents a divalent organic linker group which may contain one or more monovalent or divalent organopolysiloxane groups and/or one or more monovalent or divalent perfluorohydrocarbyl groups; n is an integer of at least 1; and (ii) one or more vinyl compounds selected from vinyl ethers, vinyl esters, vinylsiloxanes, (meth) acrylamides and 1-alkenes having from 4 to 20 carbon atoms, said vinyl compounds being copolymerizable with the compound having repeating units of formula (I); and (iii) a polymerization initiator system.

IPC Classes  ?

• A61K 6/00 - Preparations for dentistry
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/10 - Compositions for taking dental impressions

Abstract

The present invention relates to a process for the preparation of a dental resin-modified glass ionomer composition comprising a polymerizable polyacidic polymer, wherein the process comprises providing a linear polyacidic acrylic polymer having repeating units of following formula (l)wherein A, which may be the same or different, independently is selected from a group of the following formula (la) to (lf):reacting the linear polyacidic acrylic polymer with one or more polymerizable compounds in a solvent for preparing a polymerizable linear polyacidic acrylic polymer having polymerizable pendant groups linked to the acrylic polymer backbone by amide groups; and combining the polymerizable linear polyacidic acrylic polymer having polymerizable pendant groups linked to the acrylic polymer backbone by amide groups with a reactive dental glass capable of reacting with the polyacidic acrylic polymer in a cement reaction.

IPC Classes  ?

• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements
• C08F 8/30 - Introducing nitrogen atoms or nitrogen-containing groups
• C08F 292/00 - Macromolecular compounds obtained by polymerising monomers on to inorganic materials

Abstract

The present invention relates to an aqueous dental glass ionomer composition for use in the treatment of cavitated carious lesions, which composition comprises a water-soluble, polymerizable polymer comprising acidic groups, which is reactive with the particulate glass in a cement reaction, whereby the polymerizable polymer has a polymer backbone and pendant groups having one or more polymerizable carbon-carbon double bonds. The dental glass ionomer composition is used as a permanent direct restoration.

IPC Classes  ?

• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements

Abstract

The present invention relates to a process for the preparation of a dental resin- modified glass ionomer composition comprising a polymerizable polyacidic polymer, wherein the process comprises the following steps as further defined in claim 1.

IPC Classes  ?

• C08F 8/30 - Introducing nitrogen atoms or nitrogen-containing groups
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to an aqueous dental glass ionomer composition for use in the treatment of cavitated carious lesions, which composition comprises a water-soluble, polymerizable polymer comprising acidic groups, which is reactive with the particulate glass in a cement reaction, whereby the polymerizable polymer has a polymer backbone and pendant groups having one or more polymerizable carbon-carbon double bonds. The dental glass ionomer composition is used as a permanent direct restoration.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/02 - Use of preparations for artificial teeth, for filling or for capping teeth

Abstract

The present invention relates to a dental composition comprising a specific polymerizable compound and a polymerization initiator system. Furthermore, the present invention relates to the specific polymerizable compound as such and its use in a dental composition. The specific polymerizable compound of the present invention has an N-allyl (meth)acrylamide group, which nitrogen atom is substituted with an alkyl or alkenyl group optionally substituted by a group selected from a hydroxyl group, a C1-4 alkoxy group, a tertiary amino group and a carboxyl group, wherein 1 to 8 carbon atoms in the main chain of the alkyl or alkenyl group may independently from each other be replaced by a heteroatom selected from an oxygen atom and a sulfur atom.

IPC Classes  ?

• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C07C 233/09 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
• C07C 233/20 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
• C07C 233/49 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
• C08F 26/02 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen

Abstract

The present invention relates to a dental composition comprising a specific radically polymerizable compound and a radical initiator system. Furthermore, the present invention relates to the specific radically polymerizable compound and its use in a dental composition. The specific radically polymerizable compound of the present invention has an allyl (meth)acrylamide group and a phosphoric acid ester group.

IPC Classes  ?

• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C07F 9/09 - Esters of phosphoric acids
• C08F 26/02 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
• C08F 26/04 - Diallylamine

Abstract

The present invention relates to a dental composition comprising a specific polymerizable compound and a polymerization initiator system. Furthermore, the present invention relates to the specific polymerizable compound as such and its use in a dental composition. The specific polymerizable compound of the present invention has an N-allyl (meth)acrylamide group, which nitrogen atom is substituted with an alkyl or alkenyl group optionally substituted by a group selected from a hydroxyl group, a C1-4 alkoxy group, a tertiary amino group and a carboxyl group, wherein 1 to 8 carbon atoms in the main chain of the alkyl or alkenyl group may independently from each other be replaced by a heteroatom selected from an oxygen atom and a sulfur atom.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C08L 33/26 - Homopolymers or copolymers of acrylamide or methacrylamide
• C08L 33/24 - Homopolymers or copolymers of amides or imides
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention relates to a dental composition comprising a specific radically polymerizable compound and a radical initiator system. Furthermore, the present invention relates to the specific radically polymerizable compound and its use in a dental composition. The specific radically polymerizable compound of the present invention has an allyl (meth)acrylamide group and a phosphoric acid ester group.

IPC Classes  ?

• C07F 9/09 - Esters of phosphoric acids
• C08L 33/24 - Homopolymers or copolymers of amides or imides
• C08L 33/26 - Homopolymers or copolymers of acrylamide or methacrylamide
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention relates to a dental composition which is a resin modified dental cement composition, comprising a radically polymerizable compound and a redox initiator system comprising one or more clathrate compounds comprising a host molecule and one or more guest molecules, wherein the guest molecule is an oxidising agent selected from organic peroxides and organic hydroperoxides. Furthermore, the present invention relates to a use of the redox initiator system in a dental composition which is a resin modified dental cement composition.

IPC Classes  ?

• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives
• A61K 6/61 - Cationic, anionic or redox initiators
• A61K 6/70 - Preparations for dentistry comprising inorganic additives
• A61K 6/884 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins

Abstract

The present invention relates to a dental composition which is a resin modified dental cement composition, comprising a radically polymerizable compound and a redox initiator system comprising one or more clathrate compounds comprising a host molecule and one or more guest molecules, wherein the guest molecule is an oxidising agent selected from organic peroxides and organic hydroperoxides. Furthermore, the present invention relates to a use of the redox initiator system in a dental composition which is a resin modified dental cement composition.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention relates to a dental composition comprising a dental filler containing a structural filler and silanated glass flakes. Furthermore, the present invention relates to the use of silanated glass flakes for preparing a dental composition.

IPC Classes  ?

• A61K 6/836 - Glass
• A61K 6/884 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins

Abstract

The present invention relates to a dental composition comprising a dental filler containing a structural filler and silanated glass flakes. Furthermore, the present invention relates to the use of silanated glass flakes for preparing a dental composition.

IPC Classes  ?

• A61K 6/027 - Use of non-metallic elements or compounds thereof, e.g. carbon
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry
• A61K 6/02 - Use of preparations for artificial teeth, for filling or for capping teeth

Abstract

The present invention relates to a dental composition comprising a polymerizable compound of the following formula (I): X'-L-X" (I), a photosensitizer and an iodonium salt. Furthermore, the present invention relates to the use of the polymerizable compound of formula (I) for the preparation of a dental composition.

IPC Classes  ?

• A61K 6/00 - Preparations for dentistry
• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/54 - FillingSealing
• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements

Abstract

The present invention relates to a dental composition comprising a polymerizable compound of the following formula (I): X'-L-X" (I), wherein X', L and X" are as defined in claim 1, a photosensitizer and an iodonium salt. Furthermore, the present invention relates to the use of the polymerizable compound of formula (I) for the preparation of a dental composition.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention relates to a dental composition comprising (i) an acidic polymerizable compound of the following formula (la), (lb) (Ic) wherein X, Y, Y', Z, L, R2, R3 and R4 are as defined in claim 1; and (ii) an initiator system. Furthermore, the present invention relates to the use of the polymerizable compound of formula (I) for the preparation of a dental composition.

IPC Classes  ?

• A61K 6/54 - FillingSealing
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to a dental composition comprising (i) an acidic polymerizable compound of the following formula (la), (lb) (Ic) wherein X, Y, Y', Z, L, R2, R3 and R4 are as defined in claim 1; and (ii) an initiator system. Furthermore, the present invention relates to the use of the polymerizable compound of formula (I) for the preparation of a dental composition.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/02 - Use of preparations for artificial teeth, for filling or for capping teeth

Abstract

Described herein are dental compositions comprising a specific homogeneous phase comprising one or more monomers so that radically polymerizable carbon-carbon double bonds and cationically polymerizable groups are present in the homogeneous phase. The dental composition further comprises a specific initiator system for initiating radical polymerization and cationic polymerization. The combination of the homogeneous phase and the initiator system provides reduced polymerization shrinkage and stress, and at the same time a higher degree of conversion leading to improved mechanical properties and absence of coloration problems upon curing.

IPC Classes  ?

• A61K 6/62 - Photochemical radical initiators

Abstract

Dental composition comprising (a) a homogeneous phase comprising monomer combinations (i) and (ii), (i) and (iii), (ii) and (iii), or (i), (ii) and (iii), or comprising monomer (iii), wherein (i) represents one or more compounds having one or more radically polymerizable carbon-carbon double bonds; (ii) represents one or more compounds having one or more cationically polymerizable groups; and (iii) represents one or more compounds having a combination of one or more radically polymerizable carbon-carbon double bonds and one or more cationically polymerizable groups; (b) an initiator system comprising (iv) one or more radical polymerization initiator of the following formula (I) wherein M is Ge or Si; R1, R2 and R3 may be the same or different, independently represent an organic group, and R4 represents a hydrogen atom, an organic or organometallic group; provided that when R4 is a hydrogen atom, the initiator system further comprises a sensitizer compound having a light absorption maximum in the range from 300 to 600 nm; (v) a cationic polymerization initiator, which is a compound selected from the following formula (II), (III) and (IV): (II) wherein R5 and R6, which may be the same or different, independently represent an aryl group which may have a substituent; and Y- represents an anion; (III) wherein R7, R8 and R9 which may be the same or different, independently represent an aryl group which may have a substituent; and Y- represents an anion; (IV) R10, R11, R12, and R13 which may be the same or different, independently represent an alkyl or aryl group which may have a substituent; and Y- represents an anion.

IPC Classes  ?

• A61K 6/087 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

An aqueous dental glass ionomer composition comprising (a) a reactive particulate glass, (b) a linear or branched polymer comprising acidic groups, which is reactive with the particulate glass in a cement reaction, whereby the linear or branched polymer comprising acidic groups has a polymer backbone and optionally pendant groups, (c) optionally dispersed nanoparticles comprising grafted linear or branched polymer chains comprising acidic groups, and having a polymer backbone characterized in that a polymer backbone of the linear or branched polymer of component (b) and/or, if present, the grafted linear or branched polymer chains of component (c) are obtainable a process comprising (i) cyclopolymerizing or cyclocopolymerizing one or more compounds of the following formula (I):

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention relates to a dental composition comprising a specific polymerization initiator system comprising a compound having an acylsilyl- or acylgermanyl-group. The present invention also relates the use of the compound having an acylsilyl- or acylgermanylgroup for the preparation of a dental composition.

IPC Classes  ?

• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to a dental composition comprising an initiator system comprising a sensitizer compound having an acylsilyl- or acylgermyl-group and a specific coinitiator compound. The present invention also relates to an initiator system consisting essentially of the sensitizer compound having an acylsilyl- or acylgermyl-group and a coinitiator compound wherein a C-H bond dissociation energy is less than 95 Kcal/mol. Furthermore, the present invention relates to the use of this initiator system for the preparation of a dental composition.

IPC Classes  ?

• A61K 6/62 - Photochemical radical initiators

Abstract

The present invention relates to a dental composition comprising a specific polymerization initiator system comprising a compound having an acylsilyl- or acylgermanyl-group. The present invention also relates the use of the compound having an acylsilyl- or acylgermanylgroup for the preparation of a dental composition.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention relates to a dental composition comprising an initiator system comprising a sensitizer compound having an acylsilyl- or acylgermyl-group and a specific coinitiator compound. The present invention also relates to an initiator system consisting essentially of the sensitizer compound having an acylsilyl- or acylgermyl-group and a coinitiator compound wherein a C-H bond dissociation energy is less than 95 Kcal/mol. Furthermore, the present invention relates to the use of this initiator system for the preparation of a dental composition.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention relates to a polymerizable polyacidic polymer and to a process for preparing the polymerizable polyacidic polymer. Furthermore, the present invention relates to an aqueous dental composition comprising the polymerizable polyacidic polymer, to a use of the polymerizable polyacidic polymer for the preparation of a dental composition and to an acrylic acid derivative copolymer.

IPC Classes  ?

• C08F 220/06 - Acrylic acidMethacrylic acidMetal salts or ammonium salts thereof
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C08F 222/38 - Amides
• C08F 8/30 - Introducing nitrogen atoms or nitrogen-containing groups

Abstract

The present invention relates to an aqueous dental composition having a pH of less than 7 as well as to the use of a stabilizer for the preparation of an aqueous dental composition having a pH of less than 7. In particular, the present invention relates to an aqueous dental composition having a pH of less than 7 comprising (i) one or more polymerizable compounds having at least one polymerizable double bond; (ii) a polymerization initiator system containing a) an 1,2-diketone photoinitiator compound having a light absorption maximum in the range from 300 to 500 nm; and b) a coinitiator compound; (iii) a stabilizer of the following formula (I) and/or (II), wherein the Rs, which may be the same or different, independently represent a branched C3-8 alkyl or alkenyl group, or a C3-8 cycloalkyl or cycloalkenyl group, R' represents a hydrogen atom, a C1-6 alkyl or C2-6 alkenyl group, or a C1-6 fluoroalkyl or C2-6 fluoroalkenyl group, X represents a group selected from a C1-8 alkyl group or a C3-8 cycloalkyl group, and n is 0, 1 or 2; and a solvent mixture comprising an organic solvent and at least 1 percent by weight of water based on the total weight of the aqueous dental composition.

IPC Classes  ?

• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives

Abstract

Disclosed is an aqueous dental composition having a pH of at most 7, which has good wetting properties to a dental surface and an advantageous viscosity, and which may find utility as a dental adhesive composition, a dental bonding agent, a dental primer, a dental infiltrant, a pit and fissure sealant, a dental desensitizing composition, a pulp capping composition, a dental composite, dental glass ionomer cement, a dental ment, a seal and protecting composition for naked tooth necks, or a dental root canal sealer composition. The present aqueous dental composition comprises: a polymerizable compound of formula (l): A-L-B; a polymerizable compound of formula (V): A'-U-A'; one or more polymerizable monomers having one or more acidic groups; an initiator system; a stabilizer; and a solvent mixture comprising water and an organic solvent.

IPC Classes  ?

• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to an aqueous dental composition having a pH of less than 7 as well as to the use of a stabilizer for the preparation of an aqueous dental composition having a pH of less than 7. In particular, the present invention relates to an aqueous dental composition having a pH of less than 7 comprising (i) one or more polymerizable compounds having at least one polymerizable double bond; (ii) a polymerization initiator system containing a) an 1,2-diketone photoinitiator compound having a light absorption maximum in the range from 300 to 500 nm; and b) a coinitiator compound; (iii) a stabilizer of the following formula (I) and/or (II), wherein the Rs, which may be the same or different, independently represent a branched C3-8 alkyl or alkenyl group, or a C3-8 cycloalkyl or cycloalkenyl group, R' represents a hydrogen atom, a C1-6 alkyl or C2-6 alkenyl group, or a C1-6 fluoroalkyl or C2-6 fluoroalkenyl group, X represents a group selected from a C1-8 alkyl group or a C3-8 cycloalkyl group, and n is 0, 1 or 2; and a solvent mixture comprising an organic solvent and at least 1 percent by weight of water based on the total weight of the aqueous dental composition.

IPC Classes  ?

• A61K 6/00 - Preparations for dentistry
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to an aqueous dental composition having a pH of at most 7. Furthermore, the present invention relates to the use of a specific composition for the preparation of an aqueous dental composition.

IPC Classes  ?

• C07D 295/185 - Radicals derived from carboxylic acids from aliphatic carboxylic acids
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present application relates to the use of a mixture for the preparation of a dental composition. The mixture comprises: a water-soluble, polymerizable polymer comprising acidic groups, which is reactive with the particulate glass in a cement reaction, whereby the polymerizable polymer has a polymer backbone and hydrolysis-stable pendant groups having one or more polymerizable carbon-carbon double bonds, that is obtainable by a defined process; and a hydrolysis-stable, water-soluble monomer having one polymerizable double bond and optionally a carboxylic acid group, said monomer having a molecular weight of at most 200 Da.

IPC Classes  ?

• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements

Abstract

The present invention is directed to providing an aqueous dental glass ionomer composition providing improved mechanical properties including high flexural strength and a clinically relevant adhesion to tooth structure after curing, as well as hydrolysis-stability in an aqueous medium before and after curing, in particular in an acidic medium. An aqueous dental glass ionomer composition of the invention may comprise a reactive particulate glass, a specific water-soluble, polymerizable polymer comprising acidic groups, a specific water-soluble, polymerizable monomer, a polymerization initiator system, and a polymerizable hydrolysis-stable crosslinker having at least two polymerizable carbon-carbon double bonds.

IPC Classes  ?

• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements

Abstract

The present invention relates to an aqueous dental glass ionomer composition comprising (A) a reactive particulate glass, (B) a water-soluble, polymerizable polymer comprising acidic groups, which is reactive with the particulate glass in a cement reaction, whereby the polymerizable polymer has a polymer backbone and hydrolysis-stable pendant groups having one or more polymerizable carbon-carbon double bonds, wherein the polymerizable polymer is obtainable by a process comprising a) a step of copolymerizing a mixture comprising (i) a first copolymerizable monomer comprising at least one optionally protected carboxylic acid group and a first polymerizable organic moiety, and (ii) a second copolymerizable monomer comprising one or more optionally protected primary and/or secondary amino groups and a second polymerizable organic moiety, for obtaining an amino group containing copolymer; b) a step of coupling to the amino group containing copolymer a compound having a polymerizable moiety and a functional group reactive with an amino group of repeating units derived from the second copolymerizable monomer in the amino group containing copolymer obtained in the first step, wherein the optionally protected amino group is deprotected, so that polymerizable pendant groups are linked to the backbone by hydrolysis-stable linking groups, and, optionally, a step of deprotecting the protected carboxylic acid group after step a) or step b), for obtaining a polymerizable polymer; (C) a hydrolysis-stable, water-soluble monomer having one polymerizable double bond and optionally a carboxylic acid group, said monomer having a molecular weight of at most 200 Da; (D) a polymerization initiator system; and (E) a polymerizable hydrolysis-stable crosslinker having at least two polymerizable carbon-carbon double bonds.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

A unit dose package for a dental composition, comprising: (a) a rigid support member having a proximal end and a distal end, the rigid support member supporting one or more storage compartments for the dental composition and providing fluid flow communication between the one or more storage compartments and one or more discharge orifices, wherein the one or more storage compartments each have a volume of 10 pi to 1000 pi, and (b) a discharge conduit having a longitudinal axis extending from a proximal end to a distal end, the discharge conduit being rotatably attached to the distal end of the rigid support member for rotation around its longitudinal axis, wherein the attachment of the discharge conduit (b) and the rigid support member (a) is provided by two-component injection molding; whereby fluid flow communication between the discharge conduit and the one or more storage compartments may be established by rotating the discharge conduit around its longitudinal axis relative to the rigid support member from a first position to a second position and whereby the fluid flow communication between the discharge conduit and the one or more storage compartments may be interrupted by rotating the discharge conduit around its longitudinal axis relative to the rigid support member from the second position to the first position, wherein the one or more storage compartments are provided by flexible films made of composite material films, which are attached to the rigid support member.

IPC Classes  ?

• A61C 5/06 - Amalgam presses or mixers
• B65D 83/00 - Containers or packages with special means for dispensing contents

Abstract

A unit dose package for a dental composition, comprising: (a) a rigid support member having a proximal end and a distal end, the rigid support member supporting one or more storage compartments for the dental composition and providing fluid flow communication between the one or more storage compartments and one or more discharge orifices, wherein the one or more storage compartments each have a volume of 10 pi to 1000 pi, and (b) a discharge conduit having a longitudinal axis extending from a proximal end to a distal end, the discharge conduit being rotatably attached to the distal end of the rigid support member for rotation around its longitudinal axis, wherein the attachment of the discharge conduit (b) and the rigid support member (a) is provided by two-component injection molding; whereby fluid flow communication between the discharge conduit and the one or more storage compartments may be established by rotating the discharge conduit around its longitudinal axis relative to the rigid support member from a first position to a second position and whereby the fluid flow communication between the discharge conduit and the one or more storage compartments may be interrupted by rotating the discharge conduit around its longitudinal axis relative to the rigid support member from the second position to the first position, wherein the one or more storage compartments are provided by flexible films made of composite material films, which are attached to the rigid support member.

IPC Classes  ?

• A61C 5/62 - Applicators, e.g. syringes or guns
• A61C 5/64 - Applicators, e.g. syringes or guns for multi-component compositions
• B32B 15/08 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
• B32B 15/20 - Layered products essentially comprising metal comprising aluminium or copper
• B65D 83/00 - Containers or packages with special means for dispensing contents

Abstract

The present invention relates to a dental composition comprising a polymerization initiator system comprising an aromatic tertiary phosphine compound, as well as to a use of said aromatic tertiary phospine compound for the preparation of a photocurable dental composition. In particular, the present invention relates to a dental composition comprising (a) one or more compounds having at least one polymerizable double bond; (b) a polymerization initiator system comprising (b1) a sensitizer; and (b2) an aromatic tertiary phosphine compound of the following formula (I): Z-R (I) wherein Z is a group of the following formula (II) R(Ar)P-(II) wherein R1 represents a substituted or unsubstituted hydrocarbyl group; Ar represents a substituted or unsubstituted aryl or heteroaryl group; R is an aryl group, which may be substituted by one or more groups selected from a hydroxyl group, an amino group, a –NR2R3 group (wherein R2 and R3, which may be the same or different, are selected from C1-6 alkyl groups), a carboxyl group, and a group having a polymerizable double bond; wherein the group R and Ar may be substituted by one or more groups selected from a hydroxyl group, an oxo group, a –NR2R3 group (wherein R2 and R3, which may be the same or different, are selected from a hydrogen atom and C1-6 alkyl groups), a carboxyl group, and a group having a polymerizable double bond, and L may be substituted by one or more groups selected from a hydroxyl group,an oxo group, a –NR2R3 group (wherein R2 and R3, which may be the same or different, are selected from a hydrogen atom and C1-6 alkyl groups), a carboxyl group, and a group having a polymerizable double bond.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

Process for the preparation of a particulate dental filler composition, comprising the following steps: (a) introducing a mixture containing (a1) a silica precursor component, and (a2) a solution or dispersion of one or more compounds selected from compounds of aluminum, zinc, titanium, zirconium, tungsten, ytterbium, hafnium, bismuth, barium, strontium, silver, tantalum, lanthanum, tin, boron, and cerium, into a pulsed reactor; (b) converting the silica precursor component and the compounds into a particulate mixed oxide with a pulsed gas flow resulting from flameless combustion; (c) isolating the particulate mixed oxide from the pulsed reactor; (d) optionally subjecting the particulate mixed oxide to a heat treatment step; and (e) treating the optionally heat-treated particulate mixed oxide with a silane treatment agent for obtaining a particulate dental filler composition.

IPC Classes  ?

• A61K 6/54 - FillingSealing
• A61K 6/76 - Fillers comprising silicon-containing compounds
• A61K 6/884 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
• C01B 13/20 - Methods for preparing oxides or hydroxides in general by oxidation of elements in the gaseous stateMethods for preparing oxides or hydroxides in general by oxidation or hydrolysis of compounds in the gaseous state

Abstract

Process for the preparation of a particulate dental filler composition, comprising the following steps: (a) introducing a mixture containing (a1) a silica precursor component, and (a2) a solution or dispersion of one or more compounds selected from compounds of aluminum, zinc, titanium, zirconium, tungsten, ytterbium, hafnium, bismuth, barium, strontium, silver, tantalum, lanthanum, tin, boron, and cerium, into a pulsed reactor; (b) converting the silica precursor component and the compounds into a particulate mixed oxide with a pulsed gas flow resulting from flameless combustion; (c) isolating the particulate mixed oxide from the pulsed reactor; (d) optionally subjecting the particulate mixed oxide to a heat treatment step; and (e) treating the optionally heat-treated particulate mixed oxide with a silane treatment agent for obtaining a particulate dental filler composition.

IPC Classes  ?

• A61K 6/02 - Use of preparations for artificial teeth, for filling or for capping teeth
• A61K 6/00 - Preparations for dentistry
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C01B 13/20 - Methods for preparing oxides or hydroxides in general by oxidation of elements in the gaseous stateMethods for preparing oxides or hydroxides in general by oxidation or hydrolysis of compounds in the gaseous state
• C09C 1/30 - Silicic acid

Abstract

Dental composition comprising (a) at least two di- or polyepoxides having 2 to 5 epoxide groups and having a molecular weight of from 200 to 700 Da, or a macromonomeric reaction product obtainable by reacting the diepoxide with a dicarboxylic acid in a molar ratio [diepoxide]/[dicarboxylic acid] of at least 2; (b) one or more primary monoamines and/or disecondary diamines; (c) optionally one or more aliphatic polyamines; (d) a particulate filler, wherein the molar ratio of epoxide groups in component (a) to the N-H bonds in component (b) and (c) [epoxide(a)]/[N-H (b),(c)] is in the range of from 0.9 to 1.1; wherein the di- or polyepoxide having 2 to 5 epoxide groups is a compound of the following formula (I): A(BZm)n (I) wherein A represents an n-valent organic moiety optionally having 1 to 10 heteroatoms selected from oxygen atoms and sulfur atoms; and B represents an m+1-valent organic moiety, Z is an epoxide group which may have a substituent, m which are independent from each other represent an integer of at least 1; and n is an integer of from 1 to 5; wherein the m are selected so that 2 to 5 epoxide groups are present; wherein the composition does not contain any 2,2-bis-(4-hydroxyphenyl)-propane, or 2,2-bis-(4-hydroxyphenyl)-methane.

IPC Classes  ?

• C07D 301/16 - Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof formed in situ, e.g. from carboxylic acids and hydrogen peroxide
• C07D 303/23 - Oxiranylmethyl ethers of compounds having one hydroxy group bound to a six-membered aromatic ring, the oxiranylmethyl radical not being further substituted, i.e.
• C08G 65/02 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
• C08L 63/00 - Compositions of epoxy resinsCompositions of derivatives of epoxy resins
• A61K 6/087 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

(i) 5 to 80 percent by weight based on the total weight of the composition of a polymerizable matrix containing polymerizable monomers; (ii) a polymerization initiator system containing (a) an alpha-diketone photoinitiator compound having a light absorption maximum in the range from 300 to 500 nm; (b) a coinitiator compound of the following formula (I): A-H (I) wherein A is a moiety of the following formula (II) R1 R2R3X (II) wherein X represents Si, Ge, or Sn and R1 represents a hydrogen atom, an organic moiety or a different moiety A; R2 and R3 which are independent from each other, represent an organic moiety; and (c) one or more compounds selected from the following group: (1) an iodonium compound of the following formula (III): R4-l+-R5 Y- (III) wherein R4 and R5 which are independent from each other represent an organic moiety, and Y- is an anion; (2) a sulfonium compound of the following formula (IV): R6R7R8S+ Y- (IV) wherein R6, R7 and R8 which are independent from each other, represent an organic moiety or wherein any two of R6, R7 and R8 form a cyclic structure together with the sulfur atom to which they are bound, and Y- is an anion; (3) a phosphonium compound of the following formula (V): R9R10R11 P+ Y- (V) wherein R9, R10 and R11 which are independent from each other, represent an organic moiety, and Y- is an anion; and (4) a pyridinium salt.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention provides a dental composition comprising a polymerizable compound of the following formula (l):(see formula I)wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. The dental composition of the present invention may be a dental adhesive composition, a dental pit and a fissure sealer, a dental composite, and a root canal filling composition.

IPC Classes  ?

• A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• A61K 6/54 - FillingSealing
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention provides a dental composition comprising a polymerizable compound of the following formula (I), (II) and/or formula (III): wherein R1, R2, R3, R4, R5, R6, R7, and R8, and, if present, R9, and R10 are as defined by the claims.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C07C 43/20 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
• C07C 69/54 - Acrylic acid estersMethacrylic acid esters

Abstract

Provided are dental composites comprising a polymerizable composition which does not require the use of 2,2-bis[4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propane (bis-GMA), bisphenol-A dimethacrylate, ethoxylated bis-GMA, or any other raw material based on bisphenol-A for providing superior properties including mechanical properties, refractive index, and viscosity even in the absence of solvents. Also provided are processes for the preparation of a polymerizable composition which may be used in a dental composite whereby the composition provides superior properties including mechanical properties, refractive index, and viscosity even in the absence of solvents and which does not require the use of 2,2-bis[4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propane (bis-GMA), bisphenol-A dimethacrylate, ethoxylated bis-GMA, or any other raw material based on bisphenol-A.

IPC Classes  ?

• A61K 6/889 - Polycarboxylate cementsGlass ionomer cements

Abstract

Dental composite comprising (i) a polymerizable composition obtainable by reacting a mixture comprising: (a) x equivalents of one or more compounds of the following formula (I), wherein U is an (l+1)-valent hydrocarbon group which may contain in its backbone 1 to 3 heteroatoms selected from oxygen atoms and sulfur atoms and which may be substituted by one or more hydroxyl groups or groups -COOL" wherein L" is a polymerizable moiety; I is an integer of from 1 to 3; (b) y equivalents of one or more compounds of the following formula (lla), (llb) and/or (llc), wherein n is an integer of from 1 to 3, Y may be present or absent, and when present represents a carbonyl group; Y' independently may be present or absent, represents a carbonyl group; Rm which may be the same or different represent 1 to 3 substituents selected from halogen atoms, alkyl groups, and alkoxy groups, or wherein two Rm form together with the carbon atoms of the ring to which they are bonded an annelated aromatic ring; and (c) z equivalents of one or more compounds of formula (III), wherein R1 is a hydrogen atom or an alkyl group; k is an integer of from 1 to 3, whereby when k is 1, 2 or 3, then L is a (k+1)-valent hydrocarbon group which may contain 1 to 3 heteroatoms selected from oxygen atoms and sulfur atoms, and X is a carboxylic acid group, or a hydroxyl group bonded to an aromatic ring forming part of L; or wherein 0.05 < x/y < 0.66, and (see formula (1)), wherein x, y, and z are the molar equivalents of components (a), (b) and (c) and (see formula 2) is the mean acid functionality of component (a), wherein I is as defined in formula (I); and optionally reacting the hydroxyl groups and/or carboxylic acid groups on L' of the reaction product of the mixture with a compound having a polymerizable double bond; and (ii) a particulate filler.

IPC Classes  ?

• A61K 6/087 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Photocurable dental composition comprising (a) one or more radical-polymerizable monomers, and (b) 0.1 to 7.0 percent by weight based on the total weight of radical polymerizable monomers in the composition of a compound of the following formula (I): R1R2R3X(CO)X'R4R5R6 (I) wherein X and X' which may be the same or different, independently represent Si or Ge, R1, R2, R3, R4, R5, and R6, which may be the same or different, independently represent a hydrocarbon group having 1 to 20 carbon atoms, whereby any two hydrocarbon groups of R1, R2, R3, R4, R5, and R6 may be bonded to each other and form together with either X, X' or the moiety X(CO)X' to which they are attached a 3 to 12- membered heterocyclic ring, whereby any of the hydrocarbon group or the heterocyclic ring may contain one or more keto groups other than the keto group of the X(CO)X' moiety, or be substituted by on or more groups selected from halogen atoms, a cyano group, an amino group or a hydroxy group, and in case the hydrocarbon group or the heterocyclic ring contains an alkylene chain or an alkenylene chain, one or more carbon atoms in the alkylene chain or alkenylene chain may be replaced by an oxygen atom, a sulfur atom, an amide group, an ester group, a urethane group or an NH group.

IPC Classes  ?

• A61K 6/00 - Preparations for dentistry

Abstract

A dental composition comprising a compound of the following formula (I) wherein A1, A2, A3, A4, and A5 are as defined in claim 1.

IPC Classes  ?

• A61K 6/087 - Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 487/04 - Ortho-condensed systems

Abstract

A temporary root canal sealer composition, comprising based on the total weight of the composition: (a) 0.5 to 40 wt% of a water-soluble polymer having an average molecular weight of from 5000 to 100,000; (b) 20 to 40 wt% of a particulate inorganic radioopaque filler; (c) 0.01 to 5 wt.% of an alkali resistant particulate filler having an average particle size of from 1 to 100 nm; (d) 5 to 25 wt% of an alkali earth metal hydroxide and/or alkali metal hydroxide; (e) 15 to 45 wt% of water; and (f) 0 to 25 wt% of a humectant.

IPC Classes  ?

• A61K 6/54 - FillingSealing

Abstract

A temporary root canal sealer composition, comprising based on the total weight of the composition: (a) 0.5 to 40 wt% of a water-soluble polymer having an average molecular weight of from 5000 to 100,000; (b) 20 to 40 wt% of a particulate inorganic radioopaque filler; (c) 0.01 to 5 wt.% of an alkali resistant particulate filler having an average particle size of from 1 to 100 nm; (d) 5 to 25 wt% of an alkali earth metal hydroxide and/or alkali metal hydroxide; (e) 15 to 45 wt% of water; and (f) 0 to 25 wt% of a humectant.

IPC Classes  ?

• A61K 6/00 - Preparations for dentistry

Abstract

A composition comprising a polymerizable compound of the following formula (I) A is a group of the following formula (II) wherein X1 is CO or CS; X2 is a single bond, CO, CS, CH2, or a group Z[X'Z']k, wherein X' is an oxygen atom, a sulfur atom or NR, (wherein R is a hydrogen atom, a straight chain or branched C1-16 alkyl group which may be substituted by a C3-6 cycloalkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -0-PO3M2 or -SO3M, a C3-6 cycloalkyl group which may be substituted by a C1-16 alkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -0-PO3M2 or -SO3M, a C6-14 aryl or C3-14 heteroaryl group which may be substituted by -COOM, -PO3M, -O-PO3M2 or -SO3M), Z is a straight chain or branched C1-4 alkylene group, Z' is a bond, a straight chain or branched C1-4 alkylene group, and k is an integer of from 1 to 50; is a monocylic, bicyclic or tricyclic cycloalkyl group having 3 to 20 carbon atoms or a monocylic, bicyclic or tricyclic heterocycloalkyi group having 2 to 20 carbon atoms and 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen atoms, which groups may be substituted with 1 to 3 groups selected from a C1-16 alkyl group, - COOM, -PO3M, -O-PO3M2 or -SO3M; R1 is a hydrogen atom, -COOM, a straight chain or branched C1-16 alkyl group which may be substituted by a C3-6 cycloalkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -O-PO3M2 or -SO3M, a C3-6 cycloalkyl group which may be substituted by a C1-16 alkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -O-PO3M2 or -SO3M, a C6-14 aryl or C3-14 heteroaryl group which may be substituted by -COOM, -PO3M, - O-PO3M2 or -SO3M, R2 is a hydrogen atom, -COOM, a straight chain or branched C1-16 alkyl group which may be substituted by a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -O-PO3M2 and -SO3M, a C3-6 cycloalkyl group which may be substituted by a C1-16 alkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -O-PO3M2 or -SO3M, or a C6-14 aryl or C3-14 heteroaryl group which may be substituted by -COOM, -PO3M, - O-PO3M2 and -SO3M, L is a single bond or an (n+1 ) -valent linker group; B independently is a group according to the definition of A, a group of the following formula (III) wherein X1 independently has the same meaning as defined for X1 in formula (II), CH2, or a group [X'Z]k, wherein X' is an oxygen atom, a sulfur atom or NH, Z is a straight chain or branched C1-4 alkylene group, and k' is an integer of from 1 to 50; R1 and R2 are independent from each other and independently have the same meaning as defined for formula (II), a group of the following formula (IV) wherein X2 independently has the same meaning as defined for X1 in formula (III) wherein X1 independently has the same meaning as defined for X1 in formula (II), CH2, or a group [X'Z]k', wherein X' is an oxygen atom, a sulfur atom or NH, Z is a straight chain or branched C1-4 alkylene group, and k' is an integer of from 1 to 50; R1 and R2 are independent from each other and independently have the same meaning as defined for formula (II), R is a hydrogen atom, a straight chain or branched C1-16 alkyl group which may be substituted by a C3-6 cycloalkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -O-PO3M2 or -SO3M, a C3-6 cycloalkyl group which may be substituted by a C1-16 alkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -O- PO3M2 or -SO3M, a C6-14 aryl or C3-14 heteroaryl group which may be substituted by - COOM, -PO3M, -O-PO3M2 or -SO3M, a group of the following formula (V) wherein X3 is CH2, CO, -CH2CO-, CS, or -CH2CS-, R1 and R2 which are independent from each other and independently have the same meaning as defined for formula (II), or a group [ Z'X"]mE, wherein Z' is a straight chain or branched C1-4 alkylene group, X" is an oxygen atom, a sulfur atom or NR, (wherein R is a hydrogen atom, a straight chain or branched C1-16 alkyl group which may be substituted by a C3-6 cycloalkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -O-PO3M2 or -SO3M, a C3-6 cycloalkyl group which may be substituted by a C1-16 alkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -O-PO3M2 or-SO3M, a C6-14 aryl or C3-14 heteroaryl group which may be substituted by -COOM, - PO3M, -O-PO3M2 or -SO3M), E is a hydrogen atom, PO3M2, a straight chain or branched C1-16 alkyl group which may be substituted by a C3-6 cycloalkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -O-PO3M2 or -SO3M, a C3-6 cycloalkyl group which may be substituted by a C1-16 alkyl group, a C6-14 aryl or C3-14 heteroaryl group, -COOM, -PO3M, -O- PO3M2 or -SO3M, a C6-14 aryl or C3-14 heteroaryl group which may be substituted by - COOM, -PO3M, -O-PO3M2 or -SO3M, and m is an integer of from 1 to 10; and n is an integer of from from 1 to 6; wherein M which are independent from each other each represent a hydrogen atom or a metal atom; provided that in case L is a single bond, B cannot be a group according to the definition of A or a group of the formula (III) or (IV).

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C07D 307/14 - Radicals substituted by nitrogen atoms not forming part of a nitro radical

Abstract

Dental composition comprising a polymerizable compound of the following formula (I):A-L(B) wherein A, L, B, and n are as defined in claim 1.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention relates to a dental composition comprising a specific polymenzable compound. Furthermore, the present invention relates to the use of the specific polymerizable compound for the preparation of a dental composition. The polymerizable compound of the present invention is a water soluble yet hydrolysis stable polyfunctional polymerizable monomer. It is the problem of the invention to provide a dental composition comprising a polymerizable compound, which compound is copolymerizable with conventional (meth)acrylates and provides dental compositions with a low viscosity and excellent biocompatibility.The present invention is based on the recognition that the polymerizable compound according to the invention has a heat of polymerization which is comparable to the heat of polymerization of (meth)acrylates despite the presence of allyl groups.

Abstract

Cartridge (10) for storing and dispensing a flowable composition, which comprises (a) a hollow elongated body (11) having a proximal end (110) and a distal end (111); said elongated body (11) forming a storage chamber (112) having a first opening (113) at the proximal end (110) and a second opening (114) at the distal end (111); (b) a piston (12) slidably inserted into the first opening (113) of the elongated body (11) for sealingly closing the storage chamber (112); (c) a discharge nipple (13) having an external thread (131), which is provided at the second opening (114), whereby the external thread has a handedness defining a first direction of rotation in which an internal thread (311) engaging the external thread (131) of the discharge nipple (13) moves away from the elongated body (11); wherein the elongated body (11) is provided with a sleeve (115) at the proximal end (110), said sleeve (115) having a rack of one or more asymmetrical teeth (116) provided on the circumference of the sleeve (115), with each tooth (116) having a steep slope (117) facing the first direction and a moderate slope (118) facing a second direction opposite to the first direction.

IPC Classes  ?

• A61C 5/06 - Amalgam presses or mixers
• B65D 83/00 - Containers or packages with special means for dispensing contents
• A61J 1/20 - Arrangements for transferring fluids, e.g. from vial to syringe

Abstract

A process for the preparation of composite filler particles, comprising: (a) coating a particulate glass filler with a coating composition containing a film-forming agent, the coating layer displaying reactive groups on its surface, thereby forming a coated particulate filler; subsequently or concurrently (b) agglomerating the coated particulate filler, for providing a granulation of the coated particulate filler, wherein the granulation contains the coated particulate filler particles separated from and connected to each other by at least one coating layer, whereby the agglomeration is carried out by spray agglomeration or growth agglomeration; for providing composite filler particles having a median particle size (D50) of from 1 to 70 .mu.m, wherein reactive groups are transformed into crosslinking groups obtained by reacting reactive groups, and wherein the particulate filler is the main component by volume of the composite filler particles.

IPC Classes  ?

• A61K 6/77 - Glass

Abstract

A process for the preparation of composite filler particles, comprising: (a) coating a particulate filler having a median particle size (D50) of from 1 to 1200 nm with a coating composition containing a film-forming agent forming a coating layer on the surface of the particulate filler, said coating layer displaying reactive groups on the surface of the coating layer, said reactive groups being selected from addition polymerizable groups and step-growth polymerizable groups, thereby forming a coated particulate filler; subsequently or concurrently (b) agglomerating the coated particulate filler, optionally in the presence of a further crosslinking agent and optionally in the presence of a further particulate filler not displaying reactive groups, for providing a granulation of the coated particulate filler wherein the granulation contains the coated particulate filler particles and the optional further particulate filler particles separated from and connected to each other by at least one coating layer, whereby the at least one coating layer may be crosslinked by crosslinking groups obtained by reacting the reactive groups and optionally a further crosslinking agent; (c) optionally milling, classifying and/or sieving the granulation of the coated particulate filler; and (d) optionally further crosslinking the granulation of the coated particulate filler; for providing composite filler particles having a median particle size (D50) of from 1 to 70 μιτι, wherein reactive groups are transformed into crosslinking groups obtained by reacting reactive groups and optionally a further crosslinking agent, and wherein the particulate filler is the main component by volume of the composite filler particles.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/02 - Use of preparations for artificial teeth, for filling or for capping teeth

Abstract

Dental composition selected from a dental cement and a dental adhesive, comprising (i) a water-soluble polymerizable compound of the following formula (1), AXn (1) wherein A is a straight chain or branched linker group containing at least n nitrogen atoms, and optionally one or more acidic groups; X are moieties containing a polymerizable double bond, which X may be the same or different and are represented by the following formula (2), whereby a moiety X of formula (2) is linked to the nitrogen atom of an amino group or a carboxamide group of A, formula (2) wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group -(CH2)m-COOM, wherein M is a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond or a C1-6 alkylene group; and is an integer of at least 1; which is obtainable by a process comprising (a) a step of a step-growth polymerization of a mixture containing a polyamine and a compound having at least two carboxylic acid groups or an anhydride thereof, optionally in the presence of a compound of the following formula (5) for obtaining a polyamide: formula (5) wherein R1 and R2 are as defined above, and Y1 is a leaving group or Y1 forms an hydrolysable intramolecular group together with a carboxyl group present in R1 or R2 and the adjacent carbonyl group; and (b) a step of introducing moieties of the formula (2) by reacting the polyamide obtained in step (i) with a compound of formula (5) wherein Y1 is a leaving group and R1 and R2 are as defined above; or (c) a step of reacting a mixture containing a polyamine and a compound of formula (5) for obtaining an amine reaction product; and (d) a step of a step-growth polymerization of a mixture containing the amine reaction product obtained in (c) and a compound having at least two carboxylic acid groups or an anhydride thereof for obtaining the water-soluble polymerizable compound of the formula (1), an initiator system; optionally a polyacidic polymer; and optionally water and/or a water soluble solvent, optionally a particulate filler.

IPC Classes  ?

• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

A process for producing a water-soluble, hydrolysis-stable, polymerizablepolymer, comprising a) a step of copolymerizing a mixture comprising (i) a first copolymerizable monomer comprising at least one optionally protected carboxylic acid group and a first polymerizable organic moiety, and (ii) a second copolymerizable monomer comprising one or more optionally protected primary and/or secondary amino groups and a second polymerizable organic moiety, for obtaining an amino group containing copolymer; b) a step of coupling to the amino group containing copolymer a compound having a polymerizable moiety and a functional group reactive with an amino group of repeating units derived from the second copolymerizable monomer in the amino group containing copolymer obtained in the first step wherein the optionally protected amino group is deprotected, so that polymerizable pendant groups are linked to the backbone by hydrolysis-stable linking groups, and, optionally, a step of deprotecting the protected carboxylic acid group after step (a) or step (b), for obtaining a polymerizable polymer.

IPC Classes  ?

• C08F 8/00 - Chemical modification by after-treatment
• C08F 8/46 - Reaction with unsaturated dicarboxylic acids or anhydrides thereof, e.g. maleinisation

Abstract

A process for producing a water-soluble, hydrolysis-stable, polymerizablepolymer, comprising a) a step of copolymerizing a mixture comprising (i) a first copolymerizable monomer comprising at least one optionally protected carboxylic acid group and a first polymerizable organic moiety, and (ii) a second copolymerizable monomer comprising one or more optionally protected primary and/or secondary amino groups and a second polymerizable organic moiety, for obtaining an amino group containing copolymer; b) a step of coupling to the amino group containing copolymer a compound having a polymerizable moiety and a functional group reactive with an amino group of repeating units derived from the second copolymerizable monomer in the amino group containing copolymer obtained in the first step wherein the optionally protected amino group is deprotected, so that polymerizable pendant groups are linked to the backbone by hydrolysis-stable linking groups, and, optionally, a step of deprotecting the protected carboxylic acid group after step (a) or step (b), for obtaining a polymerizable polymer.

IPC Classes  ?

• C08F 8/00 - Chemical modification by after-treatment
• C08F 8/46 - Reaction with unsaturated dicarboxylic acids or anhydrides thereof, e.g. maleinisation
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

Dental composition comprising a water-soluble polymerizable compound of the following formula (1): wherein A is a linear or branched linker group represented by the following formula (3), wherein the nitrogen atom of at least two of the termini forms an amide bond with an X moiety; wherein R' represents a hydrogen atom or a substituted or unsubstituted aliphatic or cycloaliphatic hydrocarbon group, wherein each R may be the same or different L1, L2, and L3 which may be the same or different, independently represent a single bond, or a C2-20 straight-chain, branched or cyclic hydrocarbon group optionally containing from 1 to 6 heteroatoms selected from nitrogen and oxygen in the backbone of the hydrocarbon group, and optionally from 1 to 6 functional groups selected from carboxylic acid groups or a salt thereof, hydroxyl groups, thiol groups and amino groups, and in case a plurality of L1 and L2 are present, each of L1 and L2 may be the same or different; Q1 and Q2, which may be the same or different, independently represent a single bond or a linkage selected from an amide, a urethane, a urea and a thiourea linkage; k is an integer of at least 0, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, wherein each X may be the same or different and are represented by the following formula (2): wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group -(CH2)m-COOM, wherein M represents a hydrogen atom or a metal atom, m is an integer of from 0 to 6, L is a bond or a C1-6 alkylene group; and n is an integer of at least 2; (ii) an initiator system; optionally a polyacidic polymer; optionally water and/or a water soluble solvent; and optionally a particulate filler.

IPC Classes  ?

• A61K 6/02 - Use of preparations for artificial teeth, for filling or for capping teeth
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C07C 233/31 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

Abstract

Dental cement composition comprising (i) a particulate filler reactive with a polyacid in a cement reaction; (ii) a water-soluble polymerizable compound of the following formula (1), AXn (1) wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic groups, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, which X may be the same or different and are represented by the following formula (2) wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group -(CH2)m-Z, wherein Z is COOM, OPO3M2, PO3M2, SO3M, and M is independently a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond or a C1-6 alkylene group; and n is an integer of at least 1; provided that at least one X cannot be a (meth)acryl group; and (iii) an initiator system; optionally a polyacidic polymer having polymerizable double bonds; and optionally water.

IPC Classes  ?

• A61K 6/02 - Use of preparations for artificial teeth, for filling or for capping teeth
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61K 6/00 - Preparations for dentistry
• C07C 233/09 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
• C07C 233/31 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

Abstract

Dental composition comprising (i) a particulate filler; (ii) a polymerizable hydrolysis-stable compound of the following formula (1) AXn wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic groups, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, which X may be the same or different and are represented by the following formula (2) wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group -(CH2)m-Z, wherein Z is COOM, OPO3M2, PO3M2, SO3M, and M is independently a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond, a C1-6 alkylene group; and n is an integer of at least 1; provided that at least one X cannot be a (meth)acryl group; and (iii) an initiator system.

IPC Classes  ?

• A61K 6/02 - Use of preparations for artificial teeth, for filling or for capping teeth
• A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C07C 233/31 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
• C07C 233/09 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton