Odor management for fleets of vehicles may be achieved using multivariate odor sensors comprising pluralities of reactive sites connected to transducers to detective physical changes in sites due to interactions with volatile organic compounds. Onboard systems may include multiple odor sensors, both in vehicle interior zones and outside the vehicle, to help determine the best odor remediation protocols to be applied in specific circumstances, and the efficacy of applied remediation efforts. Machine models for interpreting odor identities, intensities, and user preferences may be improved by harvesting fleet odor operations data and via querying users.
1201231231233) defined on the basis of at least one measurement (S) of the multiphase system. According to this at least one characteristic operating value and at least one predefined reference value, it comprises determining an operating state (E0, E1, E2, E3) of the interaction arm (20) of the optical interferometer (14) and/or of at least one of the N outputs of the multimode coupler (24).
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
3.
METHOD FOR DETECTING BIOLOGICAL OBJECTS BY MEANS OF SURFACE PLASMON RESONANCE IMAGING
COMMISSARIAT À L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE GRENOBLE ALPES (France)
Inventor
Andrei, Cristina-Cassiana
Herrier, Cyril
Slimani, Sami
Hou-Broutin, Yanxia
Moreau, Christophe
Livache, Thierry
Abstract
A method for detecting biological objects by means of an SPR imaging detection system comprising an optical measurement device configured to generate plasmon resonance on a functionalized surface when said surface is exposed to a gas; the method comprising: an assimilation step by exposing the functionalized surface to a sample of interest formed of an aqueous carrier liquid containing the biological objects; a step of removing the liquid in contact with the functionalized surface and exposing the surface to a gas not containing the biological objects, said objects remaining bound to the ligands of the sensitive site of the functionalized surface; a step of acquiring an image of the sensitive site; a step of detecting the biological objects from the acquired image.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
ARYBALLE (France)
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (France)
UNIVERSITE CLAUDE BERNARD LYON 1 (France)
Inventor
Bensafi, Moustafa
Livache, Thierry
Herrier, Cyril
Ferdenzi, Camille
Dubreuil, Romain
Abstract
The present disclosure relates to a method, and the associated system, for the sensory substitution of smell in a subject, the method comprising: detecting a volatile compound or mixture of volatile compounds (15) by means of an array of sensors to produce a plurality of digital measurement signals uniquely associated with the volatile compound or mixture of volatile compounds; generating, from the plurality of digital measurement signals, a multimodal stimulation instruction comprising at least a first stimulation signal for the trigeminal system and at least a second stimulation signal for the trigeminal system having different physical and/or chemical properties from the first stimulation signal; stimulating the trigeminal system of the subject by applying each of the first and second stimulation signals by means of a plurality of actuators.
COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (France)
ARYBALLE (France)
Inventor
Laplatine, Loic
Herrier, Cyril
Livache, Thierry
Abstract
An interferometric system for detecting analytes present in a fluid sample, including: an array of Mach-Zehnder interferometers arranged periodically and rectangularly whose arms extend in a spiral and/or serpentine fashion with an aspect ratio equal to 1; and an array of sensitive surfaces each formed of receptors with which the analytes are able to interact by adsorption/desorption and arranged periodically and hexagonally.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
6.
ELECTRONIC DEVICE FOR ANALYZING AN ANALYTE PRESENT IN A FLUID COMPRISING A SENSOR AND METHOD OF REPLACING THE SENSOR
The invention relates to an electronic device (1) for analyzing an analyte (2) present in a fluid, comprising:
a sensor (10) comprising a photonic chip (12) comprising a light guide (13) in which receptors (14) are arranged capable of interacting with the analyte present in the fluid, the interaction causing a local property change, and
a sensor support (50);
a closing element (60);
a local property change transducer capable of converting the local property change into an electronic signal expressing the local property change, this transducer comprising:
a light source (130);
an optical detector (131),
the light guide comprising an interference arm (134) into which a resulting light beam is guided, characterized in that the radiant power of the resulting light beam guided into the interference arm is equal to or greater than 0.2 μW.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
7.
DEVICE AND METHOD FOR THE MULTISENSORY MEASUREMENT OF ADSORPTION AND DESORPTION OF COMPOUNDS IN A FLUID
An electronic device for multisensory measuring the adsorption and desorption of compounds present in a fluid includes at least one olfactory sensor designed to interact with a plurality of compounds likely to be present in the fluid and provide a plurality of signals representative of a presence of the organic compounds in the fluid. It further includes a processor for processing the provided signals to obtain a characterization of the fluid composition. This processor is programmed to determine the temporal evolution of at least one variable estimated on the basis of a combination of temporal variations of the provided signals and, using this temporal evolution, to provide a temporal labeling indicating a start and an end of at least an adsorption state and a desorption state relative to the provided signals.
COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (France)
Aryballe (France)
Inventor
Frances, Fabien
Venditti, Pierre
Lepeytre, Célia
Abstract
A breathing apparatus for use by the operator, is supplied with compressed air also used to manufacture the foam to be generated on site, and optionally run a pneumatic pump sucking up the foaming liquid, using suitable regulators. An automatic shut-off device is added to automatically cut off the supply elsewhere than to the breathing apparatus when the quantity of air available becomes low.
A62C 5/02 - Making of fire-extinguishing materials immediately before use of foam
A62B 7/02 - Respiratory apparatus with compressed oxygen or air
B01F 23/235 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids for making foam
B05B 7/00 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
B05B 7/24 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
B08B 3/00 - Cleaning by methods involving the use or presence of liquid or steam
9.
METHOD FOR CHARACTERIZING AN ANALYTE PRESENT IN A GAS SAMPLE CONTAINING AT LEAST ONE PARASITIC CHEMICAL SPECIES
A method for characterizing an analyte A present in a gas sample using an electronic nose including M sensitive site, a parasitic chemical species P being present in the gas sample, the method include: a phase 100 of acquiring N first signatures, where N>1, of the gas samples containing the analyte A and the parasitic species P, the gas samples exhibiting deviations ΔcP(n) which differ from one gas sample to the next; a phase 200 of solving an optimization problem so as to obtain N corrected signatures, characterising the analyte A present in the N gas samples, from the N first signatures, by optimizing to objective functions.
The invention relates to a system for the serial testing of gas (VOC) analysis chips located on silicon wafers, each of these chips comprising: - temporary receptors; - an input and an output for light energy; the system comprises a fixed frame, a test structure and a wafer/support assembly that are movable; the test structure comprises a source of light energy and an optical interface for measuring optical parameters dependent on the change in local property resulting from the receptor/analyte interaction; - a cavitary element capable of being reversibly brought into sealed contact with a chip on the wafer to define a sealed test chamber intended to receive the fluid containing the analytes for testing this chip. This system also comprises a unit for controlling the structure and the test process.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01R 31/28 - Testing of electronic circuits, e.g. by signal tracer
G01R 31/311 - Contactless testing using non-ionising electromagnetic radiation, e.g. optical radiation of integrated circuits
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
12.
METHOD AND COMPUTER PROGRAM FOR CALIBRATING AN ELECTRONIC DEVICE FOR CHARACTERIZING A FLUID, AND CORRESPONDING ELECTRONIC DEVICE
r,ir,irrr,ir,ir,i). The calibration fluids are more precisely distributed into multiple calibration groups and parameter values are determined (106) specifically for each calibration group.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
A sensor is configured to input a fluid sample and to output a corresponding signature obtained from an electric signal characterizing the fluid sample, and includes at least one reactive site; at least one transducer configured to measure at least one physical property change induced by an interaction of the fluid sample with the at least one reactive site and to produce the electric signal. It is further certified to have passed a qualification test including computing a metrics and checking that the metrics matches at least one predefined qualifying criterion, wherein the metrics includes, for a plurality of reference fluid samples, a clustering quality score of respective signatures of the plurality of reference fluid samples.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
15.
DEVICE AND METHOD FOR MULTIVARIATE MEASUREMENT OF THE PRESENCE OF COMPOUNDS IN A FLUID
i'iagii) of amplitudes captured by the separate time signals in the at least one deduced time interval; and obtain the characterisation of the composition of the fluid on the basis of the descriptive values calculated thereby.
The invention relates to a device (20) for characterising camera alignment, the device comprising a sensor (28, 30) based on a photonic chip (32) and a camera (42) arranged facing a matrix arrangement of N columns and M rows of optical outputs (38) of the photonic chip. A processing unit (48) of said device is designed (60, 62, 64) to process an image, provided by the camera (42), of spots corresponding to the optical outputs (38). More specifically, it is designed to distribute the spots in the image into M groups corresponding to the M columns and to determine (60) said M columns in the image by means of linear regression; to distribute (62) the spots of the image into N groups corresponding to the N rows and to determine (62) said N rows in the image by means of linear regression; and to characterise (64) the camera alignment by said determined M columns and N rows in the image.
The invention relates to a confinement device (12) of a photonic chip (10) for a sensor for detecting volatile organic compounds present in a fluid, the device comprising a base (24) having a plate (28) for receiving a lower face (14) for installing the photonic chip and a cover (38) positioned on the base which defines therewith an inner chamber (26, 40) for receiving a fluid to be analysed which is designed to make contact with an upper face (16) of the photonic chip. The cover further comprises an optical waveguide duct (46) which opens into the inner chamber at a distance from and opposite to one end (18) of the receiving optical waveguide of the upper face of the photonic chip, and a plurality (52) of photoreceptors opening into the inner chamber at a distance from and opposite to a plurality (22) of ends of the transmitting optical waveguides of the upper face of the photonic chip.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
18.
ELECTRONIC DEVICE FOR ANALYZING AN ANALYTE PRESENT IN A FLUID AND CONSUMABLE AND INTERCHANGEABLE SENSOR, METHOD OF MANUFACTURING SAID DEVICE AND SAID CONSUMABLE AND INTERCHANGEABLE SENSOR
The invention relates to an electronic device for analyzing an analyte (2) present in a fluid, comprising: a consumable and interchangeable sensor (10) comprising temporary receptors (14) capable of an interaction with the analyte present in the fluid, causing a change in local property; a sensor holder (50) in which the sensor is intended to be reversibly placed; and a transducer for the change in local property (130, 131; 230, 231), positioned on the sensor and/or on the sensor holder and able to convert the change in local property into an electronic signal expressing the change in local property. The sensor comprises a protection (17) for the temporary receptors. The invention also relates to the method of manufacturing this device, as well as to the consumable and interchangeable sensor and to its method of manufacturing.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 29/12 - Analysing solids by measuring frequency or resonance of acoustic waves
19.
METHOD FOR DETECTING BIOLOGICAL OBJECTS BY MEANS OF SURFACE PLASMON RESONANCE IMAGING
COMMISSARIAT À L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventor
Andrei, Cristina-Cassiana
Herrier, Cyril
Slimani, Sami
Hou-Broutin, Yanxia
Moreau, Christophe
Livache, Thierry
Abstract
The invention relates to a method for detecting biological objects by means of an SPR imaging detection system (1) comprising an optical measurement device (10) configured to generate plasmon resonance on a functionalised surface (5) when said surface is exposed to a gas; the method comprising: • an assimilation step by exposing the functionalised surface (5) to a sample of interest formed of an aqueous carrier liquid containing the biological objects; • a step of removing the liquid in contact with the functionalised surface (5) and exposing the surface to a gas not containing the biological objects, said objects remaining bound to the ligands of the sensitive site of the functionalised surface (5); • a step of acquiring an image of the sensitive site; • a step of detecting the biological objects from the acquired image.
The invention relates to a method for estimating, by means of an electronic nose, the state of transformation of a product during cooking that is capable of giving off volatile organic compounds as it transforms, the method comprising the following steps: o determining, as the product is cooking, a signature of the volatile organic compounds by means of the electronic nose; o determining a variance associated with the values of the signature; o determining a mean variance deviation by comparing the obtained variance with values from a database; o identifying the state of the product as being the first state or the second state depending on whether the variance is higher or lower than the mean variance deviation, respectively.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
22.
USE OF AT LEAST TWO VOLATILE COMPOUND PRECURSORS FOR CHARACTERISING THE ABILITY OF THE MICROORGANISMS CONTAINED IN A BIOLOGICAL SAMPLE TO RELEASE VOLATILE COMPOUNDS
Use of at least two volatile compound precursors for characterising the ability of the microorganisms contained in a biological sample to release volatile compounds, comprising the following steps: (a) bringing said sample into contact with at least two compounds which can be enzymatically metabolised to give volatile compounds, (b) detecting and optionally quantifying the volatile compound(s) released following said bringing into contact, and (c) determining, from the results of step (b), a volatile compound release profile, characterising said microorganisms contained in said biological sample. The present invention also relates to the use for comparing the microorganisms contained in different biological samples, or for studying the change, over time, of the microorganisms contained in a biological sample or else for identifying a compound capable of preventing the production of the volatile compounds.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
23.
ELECTRONIC DEVICE, METHOD AND COMPUTER PROGRAM FOR OLFACTORY ASSESSMENT OF A PRODUCT STATE
An electronic device for assessing a state of a product likely to transform by emission of volatile organic compounds includes olfactory sensors, designed to provide signals representative of a presence of volatile organic compounds in the ambient air close to the product, and a processor for processing the provided signals to obtain a signature representative of the state of the product. It further includes a memory for storing a reference signature, representative of an exposure of the olfactory sensors to a reference humid environment in which the product is not present, and a computer which computes a similarity value for similarity between the signature representative of the state of the product and the reference signature, to provide a product transformation index value from the computed similarity value.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
A method for recalibrating an electronic nose includes successively injecting, into a measurement chamber, reference gases that do not contain target compounds and that have various values of relative humidity. A measurement signal is determined in the course of each injection. Then, for each reference gas, a baseline is determined, which baseline is representative of the determined measurement signal. The baseline is also associated with the relative humidity of the reference gas present. A second correction function is determined on the basis of the determined baselines and of the predetermined values of relative humidity. The second correction function is then stored in a processing unit instead of a first correction function.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
25.
METHOD AND DEVICE FOR OBTAINING THE TEMPORAL OLFACTORY SIGNATURE OF A SAMPLE AND USES OF THE METHOD
The present invention relates to a method for characterising, by means of an electronic nose, the release kinetics of odorous compounds from a sample, comprising the following series of steps: (a) supplying a sample; (b) at a time t1, exposing the sensor array of the electronic nose to some of the gaseous medium comprising the odorous compounds released from the sample, and processing the response emitted by the sensor array of the electronic nose, after said exposure, in the form of a signal; and (c) repeating step (b) at least once, at a time t2 different from the time t1, whereby an olfactory kinetic signature characterising the sample is obtained. The present invention also relates to the use of this method for anti-counterfeiting and/or quality control purposes and for generating a data bank or database of temporal olfactory signatures. The present invention finally relates to certain devices used when implementing such methods.
G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
G16C 20/70 - Machine learning, data mining or chemometrics
26.
INTERFEROMETRIC ANALYTE DETECTION SYSTEM COMPRISING A MACH-ZEHNDER INTERFEROMETER ARRAY
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
ARYBALLE (France)
Inventor
Laplatine, Loic
Herrier, Cyril
Livache, Thierry
Abstract
The invention relates to an interferometric system (1) for detecting analytes present in a fluid sample, comprising: o an array of Mach-Zehnder interferometers (20) arranged in a periodic and rectangular manner, the arms (22) of which extend in a spiral and/or in a coil with an aspect ratio equal to 1; o an array of sensitive surfaces (30) which are each formed of receptors with which the analytes are capable of interacting by adsorption/desorption, and which are arranged in a periodic and hexagonal manner.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
27.
ODOR DETECTION DEVICE, ODOR DETECTION METHOD AND CORRESPONDING COMPUTER PROGRAM
A device includes capture sites; an imaging system for imaging the capture sites; a memory that stores a map of the capture sites including capture site shapes having respective predefined positions in the map and to be placed on an image of the capture sites, at a predefined position and in a predefined orientation so that the capture site shapes respectively indicate the areas of the image occupied by the capture sites; and a module for detecting an odor from an image of the capture sites and the map. The device includes an update module for obtaining an image of the capture sites, for determining, in the image, real areas respectively occupied by the capture sites, for determining, on the basis of the real areas, a correction of the position and/or of the orientation of the overlay of the map; and for updating the position and/or orientation of the overlay.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
There is described a system comprising: one or more micro Mach-Zehnder Interferometers or MZIs, with receptors (e.g. peptides) to compounds placed in sensing arms of said MZIs, said Mach-Zehnder Interferometers being based on one or more Multi-Mode Interference couplers or MMIs; and a processor configured to : receive data signals from said MMI-based MZI, said data signals comprising at least k sinusoids diphase of 2π/k; expressing said sinusoids in non- centered ellipses; calibrate said sinusoids by centering and circularizing said non-centered ellipses; and determine the angular phase from said centered and circularized ellipses. Described developments comprise the determination of one or more sensorgrams representing interaction kinetics of adsorption and desorption of target compounds with receptors placed in optical paths of the MMI based – MZIs; the determination of one or more signatures associated with one or more odors; the use of diverse MMI types; embodiments wherein sensors are placed in a smartwatch.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
The invention relates to an electronic device (1) for analysing an analyte (2) present in a fluid, comprising: - a sensor (10) comprising a photonic chip (12) comprising a light guide (13), in which there are arranged receptors (14) able to interact with the analyte present in the fluid, the interaction leading to a local property change, and - a sensor support (50); - a closure element (60); - a local property change transducer able to convert the local property change into an electronic signal expressing the local property change, this transducer comprising: - a light source (130); - an optical detector (131), the light guide comprising an interference arm (134) into which a resulting light beam is guided, characterized in that the light power of the resulting light beam guided into the interference arm is greater than or equal to 0.2 µW.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
An odor identification device includes capture sites designed to capture odorous volatile organic compounds present in an ambient air; an imaging system for imaging the capture sites designed to provide at least one raw image of the capture sites. The device further includes an unblurring module designed to implement an unblurring filter using an estimate of a spatial impulse response of the imaging system, on an image to be unblurred that originates from at least one raw image of the capture sites; and a module for identifying an odor from at least one image of the capture sites unblurred by the unblurring module.
p(n)p(n) which differ from one gas sample to the next; o a phase 200 of solving an optimization problem so as to obtain N corrected signatures, characterizing the analyte A present in the N gas samples, from the N first signatures, by optimizing two objective functions.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
33.
DETECTION SYSTEM FOR AN ELECTRONIC NOSE ALLOWING A PHYSICOCHEMICAL CLASSIFICATION OF ODOURS AND ELECTRONIC NOSE COMPRISING SUCH A SYSTEM
COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (France)
ARYBALLE (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventor
Hou-Broutin, Yanxia
Brenet, Sophie
Buhot, Arnaud
Livache, Thierry
Herrier, Cyril
Rousselle, Tristan
Abstract
A detection system for an electronic nose which allows a physicochemical classification of odors, that is to say a classification as a function of the physicochemical properties of the volatile compounds, or odorous molecules, making up these odors. This detection system comprises sensors with cross-reactivity with respect to volatile compounds, each sensor comprising a sensitive part functionalized by a receptor comprising a sequence formed by the repetition of an α-amino acid. The α-amino acid of the receptor of a sensor of a first series of sensors is hydrophilic, while the α-amino acid of the receptor of another sensor of the first series is hydrophobic, and the α-amino acids of the receptors of two sensors of a second series of sensors have isoelectric points which differ from one another by at least one pH unit.
There is described a computer-implemented method comprising the steps of: receiving a stream of data from a multivariate sensor measuring responses of compounds or Volatile Organic Compounds (VOCs) in a sample; during absorption phase, not requiring equilibrium phase, determining the presence of one or more compounds based on one or more models trained by machine learning; wherein said machine learning is minimizing a loss function on features from said multivariate sensor determined during absorption, equilibrium and desorption phases of said one or more compounds. Developments comprise normalizing, using regression analysis such as (incremental) Linear Discriminant Analysis and/or metric learning, performing physical actions comprising purging the sensor, continuous monitoring and/or tracking predefined compounds over time, etc. System aspects are described, comprising the use of Neural Networks and/or of generic and/or specific sensors, and/or the use of a Mach-Zehnder Interferometer and/or of a Capacitive Micromachined Ultrasonic Transducer.
A method determines a potential poisoning of a sensor of an electronic nose by a volatile compound following an exposure of the sensor to a gaseous sample including at least this volatile compound. If there is poisoning, the method determines whether the sensor is still functional such that the sensor is still capable of carrying out one or a plurality of reliable measurements, or on the contrary, whether the sensor is saturated and must no longer be used. The method may be used with any type of electronic nose.
A method implemented by a computer processing circuit connected to an electronic nose, for identifying a given item by an olfactory signature, the method making use of the electronic nose to obtain an olfactory signature, repeating the use of the electronic nose a first number K of times in order to acquire K olfactory signatures, making use of the computer processing circuit in order to estimate, on the basis of the K olfactory signatures, a model of the olfactory signature of the given item, acquiring, with an electronic nose of the same type, a current measurement of the olfactory signature of a current item of the same type as the given item, and comparing the current measurement to the model, in order to estimate a similarity (SIM) between the current item and the given item.
A method for the qualitative and/or quantitative measurement of odors present in a chamber for transformation (cooking or fermentation) of a product makes it possible to prevent the measurement environment from contamination by measurement-interfering elements produced by the transformation and released in the chamber for transformation. The method makes use of a chamber for transformation, for example an oven, and of an electronic nose, pipes a fluidic system, and a removal chamber for removing the measurement-interfering elements. The method includes a measurement mode M and a cleaning mode N. The cleaning mode comprises the following steps: -N0- optionally, flushing the chamber for transformation, preferably by ventilating it; -N1- flushing the measurement chamber with a fluid, preferably ambient air; -N2- flushing the removal chamber with a fluid, preferably ambient air; and -N3- optionally, transferring at least a portion of the flushing fluid from the removal chamber into the chamber for transformation.
This sensor (10), configured to input a fluid sample and to output a corresponding signature obtained from an electric signal (S) characterizing the fluid sample, comprises: at least one reactive site (18); at least one transducer (20) configured to measure at least one physical property change induced by an interaction of the fluid sample with said at least one reactive site (18) and to produce said electric signal (S). It is further certified (44) to have passed a qualification test comprising computing a metrics and checking that said metrics matches at least one predefined qualifying criterion, wherein the metrics comprises, for a plurality of reference fluid samples, a clustering quality score of respective signatures of the plurality of reference fluid samples.
Dispensing device including a dispensing conduit configured to convey a liquid between a supply source and a tank, the dispensing conduit including a closure system having an open state and a closed state, an analysis system including an analysis chamber and an odor sensor, a central electronic system capable of placing the closure system in the open state if an odor signal delivered by the odor sensor matches the odor of the liquid intended to fill the tank, and placing the closure system in the closed state if an odor signal delivered by the odor sensor does not match the odor of the liquid intended to fill the tank.
The invention relates to a device (2) for collecting a breath sample from a user, the device containing target compounds intended to be characterised using an analysis device (3), and comprising: a tip (10) for collecting the breath sample, the tip comprising a first tongue (15) referred to as the compression tongue, and a sampling tube (4) intended to be connected to the analysis device (3) and passing through an inner pipe (13) of the tip (10) and extending along the longitudinal axis away from and opposite the compression tongue (15).
The invention relates to an electronic device for analysing an analyte (2) present in a fluid, comprising a consumable and interchangeable sensor (10) including temporary receivers (14) capable of interacting with the analyte present in the fluid causing a local property change, a sensor holder (50) in which the sensor is intended to be reversibly positioned and a local property change transducer (130, 131; 230, 231) positioned on the sensor and/or on the sensor holder and suitable for converting the local property change into an electronic signal expressing the local property change. The sensor includes a protection (17) for the temporary receivers. The invention also relates to the method for manufacturing this device, as well as to the consumable and interchangeable sensor and the method for manufacturing same.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
This electronic device (10) for assessing the state of a product that can change through emission of volatile organic compounds comprises olfactory sensors (18) which are designed to provide signals representative of the presence of volatile organic compounds in the ambient air close to the product, and a processor (36, 42, 44, 46, 48) for processing the signals provided in order to produce a signature that is representative of the state of the product. It further comprises a memory (50) for storing a reference signature which is representative of exposure of the olfactory sensors (18) to a reference humid environment in which the product is not present, and a computer (36, 54) which computes a value for the similarity between the signature representative of the state of the product and the reference signature in order to provide a product transformation index value from the computed similarity value.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
The present invention relates to a method for characterising, by means of an electronic nose, the release kinetics of odorous compounds from a sample, comprising the following series of steps: (a) supplying a sample; (b) at a time t1, exposing the sensor array of the electronic nose to some of the gaseous medium comprising the odorous compounds released from the sample, and processing the response emitted by the sensor array of the electronic nose, after said exposure, in the form of a signal; and (c) repeating step (b) at least once, at a time t2 different from the time t1, whereby an olfactory kinetic signature characterising the sample is obtained. The present invention also relates to the use of this method for anti-counterfeiting and/or quality control purposes and for generating a data bank or database of temporal olfactory signatures. The present invention finally relates to certain devices used when implementing such methods.
kikiiϵP2)) by correcting the measurement signal associated with the second gas sample using the determined corrective parameter, and characterising the compounds of interest based on the useful signal.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
An odour identification device (100) comprises: capture sites (107) designed to capture odorous volatile organic compounds present in ambient air; a system (108) for imaging the capture sites (107), which system is designed to provide at least one raw image of the capture sites (107). The device (100) further comprises: an unblurring module (142) designed to implement an unblurring filter, using an estimate of a spatial impulse response of the imaging system (108), on an image to be unblurred that originates from at least one raw image of the capture sites (107); and a module (148) for identifying an odour from at least one image of the capture sites (107) unblurred by the unblurring module (142). Figure for the abstract:
The invention concerns a device that comprises: capture sites (107); a system (108) for imaging the capture sites (107); a memory (128) in which a map of the capture sites (107) is stored, including the shapes of the capture sites having predefined respective positions on the map and intended to be placed over an image of the capture sites (107), at a predefined position and in a predefined orientation, referred to as superposition, such that the capture site shapes respectively indicate the image areas occupied by the capture sites (107); and a module (148) for detecting an odour based on at least one image of the capture sites (107) and of the map of the capture sites (107). The invention further comprises an updating module (150) designed to implement: a step (602) of obtaining an image of the capture sites (107); a step (604) of determining, in the obtained image, actual areas respectively occupied by the capture sites (107); a step (606) of determining, based on the actual areas, a correction of the position and/or orientation of superposition of the map (700); and a step (608) of updating the position and/or the orientation of superposition based on the determined correction.
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
ARYBALLE TECHNOLOGIES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventor
Hou-Broutin, Yanxia
Brenet, Sophie
Buhot, Arnaud
Livache, Thierry
Herrier, Cyril
Rousselle, Tristan
Abstract
The invention relates to a detection system for an electronic nose which allows a physicochemical classification of odors, that is to say a classification as a function of the physicochemical properties of the volatile compounds, or odorous molecules, making up these odors. This detection system comprises sensors with cross-reactivity with respect to volatile compounds, each sensor comprising a sensitive part functionalized by a receptor comprising a sequence formed by the repetition of an α-amino acid. The α-amino acid of the receptor of a sensor of a first series of sensors is hydrophilic, while the α-amino acid of the receptor of another sensor of the first series is hydrophobic, and the α-amino acids of the receptors of two sensors of a second series of sensors have isoelectric points which differ from one another by at least one pH unit.
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
ARYBALLE (France)
Inventor
Laplatine, Loïc
Dupoy, Mathieu
Fournier, Maryse
Labeye, Pierre
Livache, Thierry
Herrier, Cyril
Abstract
A photonic integrated circuit for an interferometric sensor includes a first waveguide called sensitive arm wherein a first portion of the light radiation is propagated, the sensitive arm being exposed to a first ambient medium and to at least one compound to be detected inducing a modification of the local refractive index perceived by the evanescent part of the electromagnetic field of the first portion of the light radiation, and a second waveguide called reference arm wherein a second portion of the light radiation is propagated, an encapsulation layer encapsulating the reference arm, the encapsulation layer being impermeable to the compound or compounds to be detected, so that the reference arm is exposed only to a second ambient medium, substantially of the same nature as the first ambient medium and without the compound to be detected and interferometric sensor comprising a photonic integrated circuit according to the invention.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
G02B 6/122 - Basic optical elements, e.g. light-guiding paths
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
G02B 6/124 - Geodesic lenses or integrated gratings
50.
METHOD FOR DETERMINING A POTENTIAL POISONING OF A SENSOR OF AN ELECTRONIC NOSE BY A VOLATILE COMPOUND
Disclosed is a method for determining a potential poisoning of a sensor of an electronic nose by a volatile compound following an exposure of the sensor to a gaseous sample comprising at least this volatile compound and, if there is poisoning, for determining whether the sensor is still functional, in other words whether the sensor is still capable of carrying out one or more reliable measurements, or, on the contrary, whether the sensor is saturated and can no longer be used. The invention as applicable to any type of electronic nose.
The present invention relates to a method implemented by a computer processing circuit (CPU) connected to an electronic nose (NN) in order to identify a given item by an olfactory signature, said method implementing (EA) the electronic nose to obtain an olfactory signature (SM), repeating (EB) the implementation of the electronic nose a first number K of times in order to acquire K olfactory signatures (S1, S2, ..., SK), implementing (EC) the computer processing circuit in order to estimate, on the basis of said K olfactory signatures, a model (SMOD) of the olfactory signature of the given item, acquiring (ED), with an electronic nose of the same type, a current measurement (SC) of the olfactory signature of a current item, of the same type as said given item (P), and comparing (EE) the current measurement with said model, in order to estimate a similarity (SIM) between the current item and the given item.
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
52.
Detection system for an electronic nose and an electronic nose comprising such a system
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
UNIVERSITÉ GRENOBLE ALPES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventor
Hou-Broutin, Yanxia
Brenet, Sophie
Livache, Thierry
Herrier, Cyril
Rousselle, Tristan
Abstract
The invention relates to a detection system for an electronic nose capable of detecting and identifying a set of compounds that can be found in a gaseous sample, the detection system comprises a plurality of cross-reactivity detection sensors (D1, D2, D3, D4, D5, D6, D7) for supplying signals representing the presence of one or more compounds of said set in the gaseous sample, and which is particularly characterised in that the detection system further comprises at least one reference sensor (RI) for supplying a signal representing the measurement noise of the detection system. The detection system further relates to an electronic nose comprising such a detection system.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
53.
METHOD AND DEVICE FOR THE QUALITATIVE AND/OR QUANTITATIVE MEASUREMENT OF ODOURS PRODUCED BY A PHYSICOCHEMICAL TRANSFORMATION OF A PRODUCT
The invention relates to a method for the qualitative and/or quantitative measurement of odours present in a product transformation (cooking or fermentation) chamber. This method makes it possible to prevent the measuring environment from being polluted by elements interfering with the measurement that are produced by the transformation and released in the transformation chamber. The method according to the invention implements a transformation chamber, for example an oven, an electronic nose, pipes and a fluidic system, a removal chamber for the elements interfering with the measurement. This method comprises a measurement mode M and a cleaning mode N. The latter comprises the following steps: -N0- optionally flushing the transformation chamber, preferably by ventilating it; -N1- flushing the measurement chamber with a fluid, preferably ambient air; -N2- flushing the removal chamber with a fluid, preferably ambient air; -N3- optionally transferring at least a portion of the flushing fluid from the removal chamber into the transformation chamber.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
55.
IMPROVED DETECTION SYSTEM FOR AN ELECTRONIC NOSE AND AN ELECTRONIC NOSE COMPRISING SUCH A SYSTEM
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
UNIVERSITÉ GRENOBLE ALPES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventor
Hou-Broutin, Yanxia
Brenet, Sophie
Livache, Thierry
Herrier, Cyril
Rousselle, Tristan
Abstract
The invention relates to a detection system for an electronic nose capable of detecting and identifying a set of compounds that can be found in a gaseous sample, which detection system comprises a plurality of cross-reactivity detection sensors (Dl, D2, D3, D4, D5, D6, D7) for supplying signals representing the presence of one or more compounds of said set in the gaseous sample, and which is particularly characterised in that it further comprises at least one reference sensor (RI) for supplying a signal representing the measurement noise of the detection system. It further relates to an electronic nose comprising such a detection system.
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE GRENOBLE ALPES (France)
ARYBALLE TECHNOLOGIES (France)
Inventor
Herrier, Cyril
Hou-Broutin, Yanxia
Gallat, François-Xavier
Livache, Thierry
Rousselle, Tristan
Abstract
The invention relates to a method for calibrating an electronic nose, said electronic nose comprising a plurality of optical sensors arranged on a surface and capable of being in contact with a gaseous medium of interest, said optical sensors being capable of delivering a signal representative of the local optical index of the gaseous medium of interest when they are excited by photons, the method being characterized in that it comprises the following steps: after having placed the electronic nose in a gaseous medium of interest at the initial pressure (P0) and the initial temperature (T0): a) sending photons in the direction of the sensors so as to excite said sensors; b) measuring the signal delivered by each of the sensors, this measurement providing as many responses as there are sensors; c) modifying the pressure and/or temperature of the gaseous medium of interest; d) repeating step b); and e) for each sensor, determining a correction factor such as a variation in the signal between steps d) and b) corrected by the correction factor either equal to or substantially equal to a variation in the signal between these same steps for a reference, said reference being provided by a reference sensor or a combination of reference sensors. Such a method allows a physical calibration, that in the present case is relative, to be performed between the different sensors.
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
A microstructured chip (3; 33; 43; 53; 63) for surface plasmon resonance (SPR) analysis, taking the form of a solid formed by: a base (5; 77); an upper surface (4; 44), at least part of which is covered with a metal layer (2; 22; 42; 52; 62); and at least one side surface (55; 66). The chip is characterized in that the aforementioned upper surface is provided with micrometric zones intended to receive species to be analyzed and selected from among n protrusions and m cavities, and in that when n+m≧2 the zones are separated from one another by planar surfaces, with n varying between 1 and j, m varying between 0 and i, and j and i being integers.
G01N 33/554 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
C40B 60/12 - Apparatus specially adapted for use in combinatorial chemistry or with libraries for screening libraries
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
58.
Microstructured chip comprising convex surfaces for surface plasmon resonance analysis, analysis device containing said microstructured chip and use of said device
A microstructured chip (3; 33; 43; 53; 63) for surface plasmon resonance (SPR) analysis, taking the form of a solid formed by: a base (5; 77); an upper surface (4; 44), at least part of which is covered with a metal layer (2; 22; 42; 52; 62); and at least one side surface (55; 66). The chip is characterized in that the aforementioned upper surface is provided with micrometric zones intended to receive species to be analyzed and selected from among n protrusions and m cavities, and in that when n+m≧2 the zones are separated from one another by planar surfaces, with n varying between 1 and j, m varying between 0 and i, and j and i being integers.
C12M 1/00 - Apparatus for enzymology or microbiology
C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
C40B 60/12 - Apparatus specially adapted for use in combinatorial chemistry or with libraries for screening libraries