A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
in vivoin vivo monitoring of an analyte level. In particular, the present invention relates to sensors having saccharides or similar molecules present in glucose-oxidase containing sensing layers to improve sensor stability.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
3.
METHOD AND APPARATUS FOR PROVIDING GLYCEMIC CONTROL
Methods and system to provide glycemic control and therapy management based on monitored glucose data, and current and/or target HbA1C levels are provided.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/1495 - Calibrating or testing in vivo probes
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
4.
SYSTEMS AND METHODS FOR CONTINUOUS GLUCOSE MONITOR COMMUNITIES
A device forms a group of users of a continuous glucose monitor (CGM) service, including creating a database association between identifiers, where each identifier is associated with a different user. The device identifies CGM sensor data for the users, including identifying a portion of the CGM sensor data associated with each user. Each portion of the CGM sensor data was generated by a corresponding CGM sensor and received from a corresponding computing device associated with the user. The device generates a CGM data report from the CGM sensor data, and the CGM data report includes glycemic data for at least two of the users. The device sends the CGM data report to a computing device associated with a user. Upon receipt of the CGM data report, the computing device displays a visual representation of the glycemic data for the subset.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
5.
STABILIZATION OF NAD(P)-DEPENDENT SENSOR WITH NEGATIVELY CHARGED MEMBRANE
The present disclosure provides analyte sensors comprising a sensing layer disposed upon a surface of a first working electrode, wherein the sensing layer comprises an NAD(P)-dependent enzyme and a supply of NAD(P); and a multilayered membrane that overcoats at least a part of the sensing layer and is permeable to an analyte, wherein the membrane comprises at least one layer of negatively charged polymer. The present disclosure also provides methods of using such analyte sensors for detecting one or more analytes preset in a biological sample and methods of manufacturing the analyte sensors.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
The present invention relates generally to systems, devices, and methods for in vivo monitoring of an analyte level. In particular, the present invention relates to sensors having saccharides or similar molecules present in glucose-oxidase containing sensing layers to improve sensor stability.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
The present disclosure provides analyte sensors comprising a polymer membrane comprising a calibrant, wherein the polymer membrane overcoats a sensing area and is permeable to a first analyte; wherein the first analyte and the calibrant are different, wherein a first enzyme in the sensing area is capable of electrolyzing both the first analyte and the calibrant; and wherein the calibrant provides a signal at sensor initialization that correlates with sensor activity. The present disclosure also provides methods of detecting a drop in sensitivity of the analyte sensors and methods of manufacturing the analyte sensors.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
C08L 39/08 - Homopolymers or copolymers of vinyl-pyridine
G01N 33/487 - Physical analysis of biological material of liquid biological material
Systems, methods and apparatus are provided, including one or more processors configured to detect a sensor calibration start event, determine outputs of one or more physiological models based on a plurality of parameters, the plurality of parameters including glucose data and insulin information, determine whether the outputs fall within a predetermined threshold, and in response to determining that the outputs fall within the predetermined threshold, execute a calibration routine.
Embodiments described herein relate to an analyte monitoring device having a user interface with a display and a plurality of actuators. The display is configured to render a plurality of display screens, including a home screen and an alert screen. The home screen is divided into a plurality of simultaneously displayed panels, with a first panel displays a rate of change of continuously monitored analyte levels in interstitial fluid, a second panel simultaneously displays a current analyte level and an analyte trend indicator, and a third panel displays status information of a plurality of components of the device. When an alarm condition is detected, the display renders the alert screen in place of the home screen, the alert screen displaying information corresponding to the detected alarm condition. Furthermore, the actuators are configured to affect further output of the analyte monitoring device corresponding to the detected condition.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G01N 33/487 - Physical analysis of biological material of liquid biological material
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16Z 99/00 - Subject matter not provided for in other main groups of this subclass
10.
SYSTEMS, DEVICES, AND METHODS FOR EPISODE DETECTION AND EVALUATION WITH INTERVENTION GUIDES, ACTION PLANS AND/OR SCHEDULING INTERFACES
Systems, devices, and methods are provided that allow detection of episodes in analyte measurements and the prompting of a subject to self-report possible causes for the episodes and take action in response to episode detection. Correlation of possible causes with detected episodes assists patient behavior modification to reduce the occurrence of episodes. Also provided is function and structure for associating episodes with visits between the subject and a Health Care Provider (HCP) and scheduling interfaces and reports for assisting the HCP in advising numerous patients.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 10/65 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records stored on portable record carriers, e.g. on smartcards, RFID tags or CD
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
11.
SYSTEMS AND DEVICES FOR RECEIVING DATA AND METHODS FOR CONTROL THEREOF
Embodiments described herein include an analyte monitoring device for receiving data in an analyte monitoring system. The analyte monitoring device includes a microprocessor, one or more communications integrated circuits electrically coupled to the microprocessor, wherein the one or more communications integrated circuits are further electrically coupled to at least one respective antenna, an input-output (IO) expander electrically coupled to the microprocessor, and one or more storage memories comprising instructions that, when operable by the microprocessor, cause the microprocessor to receive analyte data from a sensor control device of an analyte sensor in the analyte monitoring system. The IO expander increases an amount of pins of the microprocessor.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G01N 33/487 - Physical analysis of biological material of liquid biological material
Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.
A61B 5/151 - Devices for taking samples of blood specially adapted for taking samples of capillary blood, e.g. by lancets
A61B 5/157 - Devices for taking samples of blood characterised by integrated means for measuring characteristics of blood
A61B 50/30 - Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
13.
METHODS, DEVICES, AND SYSTEMS FOR PHYSIOLOGICAL PARAMETER ANALYSIS
A method of calculating at least one physiological parameter using a reticulocyte production index (RPI) value can include: measuring a plurality of first glucose levels over a first time period; measuring a first glycated hemoglobin (HbA1c) level corresponding to an end of the first time period; measuring the RPI value; calculating a red blood cell elimination constant (kage) based on the RPI value; and calculating the at least one physiological parameter selected from the group consisting of: a red blood cell glycation rate constant (kgly), a red blood cell generation rate constant (kgen), and an apparent glycation constant (K), based on (1) the plurality of first glucose levels, (2) the first HbA1c level, and (3) the kage. Further, one or more related analyses (e.g., personalized-target glucose range, personalized-target average glucose, cHbA1c, and the like) can be estimated and/or adjusted based on the at least one physiological parameter.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G01N 33/72 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood pigments, e.g. hemoglobin, bilirubin
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
14.
SYSTEMS, DEVICES, AND METHODS FOR POWER-EFFICIENT WIRELESS COMMUNICATIONS BETWEEN ELECTRONIC DEVICES
Systems, devices and methods are provided for power-efficient wireless communications between electronic devices. In particular, the embodiments disclosed herein can reduce battery consumption in a transmitting electronic device and enhance data integrity of data received by a receiving electronic device. According to the embodiments, a first electronic device transmits advertising packets according to a wireless communications protocol, wherein the advertising packets include a first payload data. In response to receiving the advertising packets, a second electronic device can transmit a scan request to the first electronic device which, in turn, terminates the transmission of advertising packets.
Systems, devices, and methods for detecting and measuring meal impact and/or an amount of time an individual is within a predetermined analyte range based on analyte measurements. These results and related information are presented to the individual to show the individual an analyte response associated with consumed meals, or change in an analyte level within a predetermined time period after meals are consumed. These results can be organized based on a ranking or scoring system so as to allow the individual to visualize analyte responses and range impact associated with the meals. Various embodiments disclosed herein relate to methods, systems, and software applications intended to engage an individual by providing direct and timely feedback regarding the individual's meal-related analyte response.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
16.
SENSOR FOR DETECTING GLUCOSE AND LACTATE AND METHODS FOR DETERMINING AEROBIC AND ANAEROBIC THRESHOLDS
The present disclosure describes lactate-responsive sensors, sensing systems incorporating a lactate-responsive sensor, and methods of use thereof that would be beneficial for continuously monitoring lactate levels and determining lactate thresholds (both aerobic and anaerobic thresholds). The present disclosure also relates to an analyte sensor for continuously detecting glucose and lactate levels.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
17.
METHOD AND APPARATUS FOR PROVIDING DATA PROCESSING AND CONTROL IN A MEDICAL COMMUNICATION SYSTEM
Techniques for data processing and control for a glucose monitoring system are provided, including obtaining a first sensitivity of a glucose sensor; obtaining a second sensitivity of the glucose sensor; comparing a difference between the first sensitivity and the second sensitivity to a predetermined range of values; if the difference is outside the predetermined range of the values, causing a calibration routine for the glucose sensor to be performed; and if the difference is within the predetermined range of values determining a composite sensitivity for a current calibration of the glucose sensor based on the first sensitivity and the second sensitivity and calculating the glucose level based on the current calibration of the glucose sensor.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1495 - Calibrating or testing in vivo probes
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
18.
FOCUSED STERILIZATION AND STERILIZED SUB-ASSEMBLIES FOR ANALYTE MONITORING SYSTEMS
A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
G06F 9/06 - Arrangements for program control, e.g. control units using stored programs, i.e. using an internal store of processing equipment to receive or retain programs
G06F 15/00 - Digital computers in generalData processing equipment in general
19.
SOFTWARE APPLICATIONS RESIDING ON HANDHELD ANALYTE DETERMINING DEVICES
Presented herein is a handheld analyte measurement device. The analyte measurement device includes one or more software applications to help the user manager their diabetes. Embodiments and descriptions of the various applications are provided below in conjunction with the handheld analyte measurement device.
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
20.
SYSTEMS AND METHODS FOR IMPROVED IN VIVO ANALYTE SENSOR FUNCTION
An analyte sensor comprising: an insertion tip configured for insertion below a tissue of a user, the insertion tip comprising: a working electrode comprising a sensing layer disposed thereon and a membrane layer disposed at least partially over the sensing layer; a substrate; and a counter electrode. Wherein a polymer layer comprising at least an immunosuppressant is disposed on an exterior surface of the working electrode, the substrate, or the counter electrode, the polymer layer being separate from the sensing layer and the membrane layer.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
An applicator for sequentially applying a plurality of sensors to a body of a user, the plurality of sensors being housed within different containers. The applicator being configured to be inserted into each of the plurality of containers to engage corresponding pucks within each of the different containers and to further engage corresponding sharps within each of the containers. The applicator being configured to move a puck carrier within the applicator between first and second positions for inserting and retracting sharps into and out of the body of the user when applying the sensors of the corresponding pucks to the user's body. The applicator also being configured with an eject button for ejecting the sharps after they have been retracted form the user's body.
Techniques are provided for dynamically managing wireless communications of glucose monitoring systems. The systems dynamically adjust the communication session intervals based on various dynamic conditions. Some systems are also configured with an antenna positioned on an opposing side of a chip from other sensor electronics and/or outside of an encasing of potting material to enhance the signaling functionality of the antenna.
Sensor systems are provided that include (i) a sensor configured to obtain sensor data indicative of an analyte level of a user's body, (ii) a first transmitter patch configured in size and shape to overlay the sensor during a first time period of use, (iii) a second transmitter patch configured in size and shape to overlay the sensor during a second time period of use. First sensor data is transmitted from the sensor to the first transmitter patch corresponding to the first time period and second sensor data is transmitted from the sensor to the second transmitter patch corresponding to the second time period. The first transmitter patch can be replaced by the second transmitter patch without removing the sensor.
Disclosed embodiments describe systems and methods for characterizing batteries. In some embodiments, a voltage is applied to a battery, the voltage having a sinusoidal waveform that varies over a plurality of frequencies, to generate a data set representing a plot including a plurality of impedance values corresponding to the plurality of frequencies measured when the voltage is applied to the battery. Embodiments further extract points from the data set representing the plot and analyze the data set representing the plots based on the points to characterize the battery.
Systems, devices and methods for the assembly and use of an applicator and a sensor control device with an improved sharp. The improved sharp has smooth outers surfaces, and comprises an elongated main body with a distal end configured to facilitate a proximal movement of the sharp through a skin surface of a user to approximately the particular insertion depth. The improved sharp also comprises a proximal end and a channel extending from the distal end to at least the proximal end within the elongated main body. The channel is configured to support and deploy a sensor at a particular insertion depth. The improved sharp further comprises a needle that extends past the distal end of the elongated main body and facilitates an initial penetration through the skin surface of the user.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
The present disclosure provides analyte sensors comprising a first working electrode, a sensing layer disposed upon a surface of the first working electrode, and a highly permeable membrane that overcoats at least a part of the sensing layer and that is permeable to an analyte, wherein the highly permeable membrane comprises a copolymer of poly(N-vinylimidazole) and poly(N-isopropylacrylamide), and wherein the analyte sensor shows a sensitivity of at least 100 nA/mM to the analyte. The present disclosure also provides methods of using such analyte sensors for detecting one or more analytes preset in a biological sample and methods of manufacturing the analyte sensors.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1495 - Calibrating or testing in vivo probes
Medical devices, systems, and methods related thereto a glucose monitoring system having a first display unit in data communication with a skin-mounted assembly, the skin-mounted assembly including an in vivo sensor and a transmitter. The first display unit and a second display unit are in data communication with a data management system. The first display unit comprises memory that grants a first user first access level rights and the second display unit comprises memory that grants a second individual second access level rights.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16Z 99/00 - Subject matter not provided for in other main groups of this subclass
Embodiments described herein include an analyte monitoring device. The analyte monitoring device generates sensor data indicative of an analyte level measured by an analyte sensor transcutaneously positioned in contact with a bodily fluid of the subject. The analyte monitoring device initializes a communication module using an advertisement scanning related instruction set, wherein the advertisement scanning related instruction set is a subset of a communications protocol startup instruction set including the advertisement scanning related instruction set and a non-advertisement scanning related instruction set. The analyte monitoring device issues one or more advertising packets and receives a connection request from a receiving device. The analyte monitoring device completes initialization of the communication module using the non-advertisement scanning related instruction set. The analyte monitoring device selects a subset of the sensor data, prepares a data packet comprising the subset of the sensor data, and transmits the data packet to the receiving device.
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
H04L 12/12 - Arrangements for remote connection or disconnection of substations or of equipment thereof
Techniques for generating and modifying user interfaces for displaying glucose sensor data are disclosed. Initial or first sensor data is displayed with a first formatting until it is dynamically changed to a second formatting that de-emphasizes the data while new sensor data is concurrently displayed with the first formatting to emphasize the new sensor data relative to the older / first sensor data.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G06T 11/20 - Drawing from basic elements, e.g. lines or circles
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
An applicator for deploying an on-body unit (OBU) includes an applicator body and one or more OBU engagement members and a working spring section that extend from the applicator body. The OBU engagement member(s) are configured to removably secure an OBU. One or more contact members extend from the working spring section. When the contact member(s) interface with the body of the subject pursuant to deployment of the OBU on the body of the subject, the working spring section is configured to (i) store compressive or bending energy in response to force applied to the applicator body in a first direction until a peak compressive or bending energy is achieved and (ii) in response to continued application of force in the first direction after the peak compressive or bending energy is achieved, release the compressive or bending energy to cause acceleration of the applicator body in the first direction.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
32.
SYSTEMS AND METHODS FOR COMMUNICATING MEDICAL SENSOR DATA TO A CLOUD SERVICE
A device may identify a portion of sensor data associated with a user, the portion of the sensor data having been collected by an analyte sensor device of the first device. The device may identify a wireless presence of a second device, the second device configured for relaying the sensor data towards a cloud service. The device may determine, based on the wireless presence of the second device, and based on one or more additional factors, to communicate the portion of the sensor data to the second device. The device may send the portion of the sensor data to the second device.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
33.
MAGNETIC INTERFERENCE MITIGATION IN MEDICAL MONITORING SYSTEMS
An analyte sensor includes an application-specific integrated circuit (ASIC), sensor hardware, and a communication module. The ASIC is communicatively coupled to the sensor hardware and the communication module. The ASIC is configured to receive measurement signals from the sensor hardware and provide an output signal to the communication module. The communication module is configured to communicate output data based on the output signal to one or more external devices. The ASIC comprises a magnetic interference detection element configured to indicate when magnetic interference is represented in a measurement signal generated by the sensor hardware. The analyte sensor is configured to disqualify sensor data associated with the analyte sensor in response to the magnetic interference detection element indicating a presence of magnetic interference in a measurement signal generated by the sensor hardware.
The present disclosure describes lactate-responsive sensors having first and second lactate-responsive sensing areas, sensing systems incorporating the lactate-responsive sensor, and methods of using the same that for continuously monitoring lactate levels and determining variance between lactate concentrations derived from signals independently obtained from the first and second lactate-responsive areas.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
36.
MULTI-RATE ANALYTE SENSOR DATA COLLECTION WITH SAMPLE RATE CONFIGURABLE SIGNAL PROCESSING
Systems, methods and apparatus are provided, including one or more processors configured to receive signals generated by an analyte sensor, a memory storing instructions which, when executed by the one or more processors, cause the one or more processors to, store a first dataset corresponding to the signals generated by the analyte sensor at a first rate in a first memory buffer, and store a second dataset corresponding to the signals generated by the analyte sensor at a second rate in a second memory buffer, wherein the second rate is a dynamic value based on a rate-of-change corresponding to the signals generated by the analyte sensor.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
37.
SYSTEMS, DEVICES, AND METHODS FOR AN ANALYTE SENSOR
A method comprising receiving a plurality of analyte data over a first time period monitored by an analyte sensor in fluid contact with bodily fluid under a skin surface, the plurality of analyte data corresponding to an analyte level, receiving a plurality of temperature data over the first time period from a temperature sensor, determining a rate of change of the plurality of temperature data over the first time period, if the determined rate of change of the plurality of temperature data is above a predetermined threshold, receiving user input to confirm exposure to radiologic procedure during the first time period, and adjusting the plurality of analyte data over the first time period based on the confirmed exposure to radiologic procedure.
Method and apparatus for optimizing analyte sensor calibration including receiving a current blood glucose measurement, retrieving a time information for an upcoming scheduled calibration event for calibrating an analyte sensor, determining temporal proximity between the current blood glucose measurement and the retrieved time information for the upcoming calibration event, initiating a calibration routine to calibrate the analyte sensor when the determined temporal proximity is within a predetermined time period, and overriding the upcoming scheduled calibration event using the current blood glucose measurement are provided.
Methods and apparatus including determining a rate of occurrence of a glycemic excursion event, determining a frequency of an alarm activation associated with the glycemic excursion event, determining an analyte level associated with the alarm activation, and setting an alarm parameter based on one or more of the determined rate of occurrence of the glycemic excursion event, the frequency of the alarm activation associated with the glycemic excursion event or the determined analyte level are provided.
A receiver is configurable to (i) send a connection request to a medical sensor via a first communication channel; (ii) receive, from the medical sensor and via the first communication channel, security data comprising at least a connection identifier associated with the medical sensor, wherein the connection identifier is configured to facilitate secure connection between the medical sensor and one or more receivers via a second communication channel that is different from the first communication channel; and (iii) facilitate secure connection between an additional receiver and the medical sensor via the second communication channel by conveying the connection identifier to the additional receiver via a third communication channel that is different from the first communication channel.
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
Systems, methods, and devices for improved sensor communications in an analyte monitoring system are provided. In some embodiments, a first remote device can be configured to establish a first wireless communication link with a sensor control device. The first remote device can then transmit sensor context information to a second remote device and deactivate the first wireless communication link. Subsequently, the second remote device can establish a second wireless communication link with the sensor control device by using the sensor context information.
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
H04W 76/15 - Setup of multiple wireless link connections
H04W 88/06 - Terminal devices adapted for operation in multiple networks, e.g. multi-mode terminals
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
An analyte sensor comprising: a sensing layer disposed on the analyte sensor; and a membrane disposed over at least a portion of the sensing layer, wherein the membrane comprises a low surface tension polymer of a modified polysiloxane in an amount of 1% or less by weight of a total formulation of the membrane.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
Methods and systems for delaying alarms that include detecting an analyte level using an analyte sensor; and delaying the annunciation of an analyte alarm after the analyte level crosses an analyte threshold, wherein the delay is based on one or both of (1) a magnitude of difference between the analyte level and the analyte threshold and (2) a duration of time in which the analyte level has crossed the analyte threshold.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
44.
USER PHYSIOLOGICAL RESPONSE PREDICTION AND MANAGEMENT SYSTEMS
A system for predicting and/or managing physiological responses is configurable to (i) access one or more images depicting one or more consumables able to influence a physiological condition of a user, the one or more images being associated with one or more timepoints; (ii) access user state information associated with the user; (iii) determine a predicted physiological response to consumption of the one or more consumables by the user based on at least the one or more images and the user state information; and (iv) present an output based on the predicted physiological response to the user via a user interface.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Improved digital interfaces, graphical user interfaces, and alarms for analyte monitoring systems are provided. For example, disclosed herein are various embodiments of methods, systems, and interfaces for Silent Mode for alarms, Temporary Mode for alarms, escalating alarms, and alarm snooze features for an analyte monitoring software application. Also, various embodiments of interface enhancements are described, including caregiver alarms, among other embodiments.
Systems, devices and methods are provided for measurement of an analyte level in a bodily fluid of a subject. In particular, disclosed herein are various embodiments of sensor control devices include a display. The display may be on or in the housing of the on-body unit. The display may be directly electronically coupled to the analyte sensor or may be indirectly electronically coupled to the analyte sensor through the sensor electronics.
Improved graphical user interfaces and wireless communication features for analyte monitoring software applications are provided. For example, disclosed herein are various embodiments of methods, systems, and interfaces for displaying data indicative of an analyte level for an analyte monitoring software application capable of receiving data according to more than one wireless communication protocol.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
48.
USER PHYSIOLOGICAL RESPONSE PREDICTION AND MANAGEMENT SYSTEMS
A system for predicting and/or managing physiological responses is configurable to (i) access one or more images depicting one or more consumables able to influence a physiological condition of a user, the one or more images being associated with one or more timepoints; (ii) access user state information associated with the user; (iii) determine a predicted physiological response to consumption of the one or more consumables by the user based on at least the one or more images and the user state information; and (iv) present an output based on the predicted physiological response to the user via a user interface.
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G06V 20/52 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects
A sensor, system, and method for estimating membrane thickness by current measurement are provided. The method includes providing a sensor having a working electrode and coating a tip of the sensor with a membrane coating such that the membrane coating is disposed over the working electrode. The method also includes embedding analyte into a capping membrane and disposing the capping membrane over at least a portion of the tip of the sensor. The method further includes detecting, by the working electrode, a plurality of signals over a period of time, determining current measurements from the plurality of signals, and estimating a thickness of the membrane coating at least in part by analyzing a relationship of the current measurements to the period of time.
An analyte monitoring device can include an analyte sensor, a sensor housing, sensor electronics, and an adhesive. The analyte sensor can be configured to be placed under a skin surface of a body part of a user and in contact with an interstitial fluid for sensing signals representative of analyte levels. The sensor housing can include a first material. Sensor electronics can couple with the analyte sensor and be disposed in the sensor housing. The sensor electronics can include a substrate defining one or more apertures, and the substrate can be made from a second material. The adhesive can be disposed on an inner surface of the sensor housing and extend through the one or more apertures of the substrate. The adhesive can form an adhesive head that couples the sensor electronics to the sensor housing.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
(1) Continuous glucose and ketone monitoring systems for monitoring glucose and ketones for the management of diabetes; sensor-based glucose monitors; sensor-based ketone monitors; sensor-based glucose and ketone monitors; medical apparatus and instruments for diabetes management, namely, sensors for monitoring glucose and ketone levels in bodily fluid and reader devices for use with glucose and ketone sensors; medical apparatus and instruments for monitoring analyte concentrations in bodily fluid; medical apparatus and instruments for determination of analyte concentrations in bodily fluid.
Medical apparatus and instruments for diabetes management use; medical apparatus and instruments for monitoring glucose; medical apparatus and instruments for monitoring ketones; medical apparatus and instruments for monitoring glucose and ketones; medical apparatus for monitoring analyte concentrations; medical apparatus and instruments for determination of analyte concentrations; sensor-based glucose monitors; sensor-based ketone monitors; sensor-based glucose and ketone monitors; glucose and ketone monitoring systems; continuous glucose monitoring systems; continuous ketone monitoring systems; continuous glucose and ketone monitoring systems; medical apparatus for determination of analyte concentrations for diabetes management purposes; medical apparatus for monitoring analyte concentrations for diabetes management purposes; patient monitoring sensors for diabetes management; diabetes management monitoring devices; sensors for diabetes management.
Medical diagnostic apparatus for determination of analyte concentrations; medical apparatus for monitoring analyte concentrations in interstitial fluid; patient monitoring sensors for monitoring analyte concentrations; sensors for monitoring analyte concentrations for health purposes; patient monitoring sensors for determination of analyte concentrations in interstitial fluid; sensors for determination of analyte concentrations in interstitial fluid for health purposes; None of the foregoing in the field of personal emergency response systems (PERS) or mobile personal emergency response systems (MPERS) except in connection with management of diabetes.
54.
METHOD AND SYSTEM FOR GLYCEMIC PREDICTION AND DYNAMIC VISUALIZATION
Disclosed herein are system, method, and computer program product embodiments for interconnecting a prediction visualization with user medical data for analyzing the impact of personal choices on future glucose levels. The prediction visualization is configured to generate predictions of glycemic impact based one or more inputs including choices involving diet and exercise and user medical data, such as the user's historical and current glucose levels. The prediction visualization is configured to be adjustable based on user input and the visualization is configured to dynamically update based on user input. The disclosed interface allows the user to adjust the sequencing of these decisions and portion sizes of meal choices and immediately generate new visualizations representing the impact on predicted future glucose levels.
Methods and devices and systems include generating analyte data based on signals from an analyte sensor transcutaneously positioned in contact with interstitial fluid under a skin layer of a user and to generate signals corresponding to an analyte level of a target analyte. The analyte data corresponds to the analyte level of the target analyte over a wear period. Methods include storing the analyte data over the wear period. Methods include determining one or more indications based on the analyte data. Methods include determining a reimbursement insurance code based at least in part on stored sensor information associated with the analyte sensor. Methods include communicating at least a portion of the analyte data and the reimbursement insurance code to an electronic record associated with the user and stored by a remote electronic medical record system. Methods include providing the one or more indications on a user interface unit.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
G06Q 50/22 - Social work or social welfare, e.g. community support activities or counselling services
G08C 17/02 - Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16Z 99/00 - Subject matter not provided for in other main groups of this subclass
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
56.
METHOD AND SYSTEM FOR GLYCEMIC PREDICTION AND DYNAMIC VISUALIZATION
Disclosed herein are system, method, and computer program product embodiments for interconnecting a prediction visualization with user medical data for analyzing the impact of personal choices on future glucose levels. The prediction visualization is configured to generate predictions of glycemic impact based one or more inputs including choices involving diet and exercise and user medical data, such as the user's historical and current glucose levels. The prediction visualization is configured to be adjustable based on user input and the visualization is configured to dynamically update based on user input. The disclosed interface allows the user to adjust the sequencing of these decisions and portion sizes of meal choices and immediately generate new visualizations representing the impact on predicted future glucose levels.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.
Method, device and system for providing consistent and reliable glucose response information to physiological changes and/or activities is provided to improve glycemic control and health management.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A dose monitoring system for an injection pen includes a dose detection assembly and an injection detection assembly. The dose detection assembly includes a housing securable to a body of the injection pen over a dose display window, an optical sensor assembly for determining an amount of movement of a dose indicator surface within the dose display window, and a processor arranged within the housing. The injection detection assembly includes a housing securable to a dose knob of the injection pen, an injection sensor for detecting a force or touch applied to the dose knob, and a transmitter to communicate injection information when the force or touch is applied. The amount of medication injected is determined based on the amount of movement of the dose indicator surface within the dose display window when the force or touch is applied to the dose knob.
The present disclosure provides analyte sensors comprising a first working electrode, a sensing layer disposed upon a surface of the first working electrode, and a highly permeable membrane that overcoats at least a part of the sensing layer and that is permeable to an analyte, wherein the highly permeable membrane comprises a copolymer of poly(N-vinylimidazole) and poly(N-isopropylacrylamide), and wherein the analyte sensor shows a sensitivity of at least 100 nA/mM to the analyte. The present disclosure also provides methods of using such analyte sensors for detecting one or more analytes preset in a biological sample and methods of manufacturing the analyte sensors.
The present disclosure provides analyte sensors comprising a sensing layer disposed upon a surface of a first working electrode, wherein the sensing layer comprises an NAD(P)-dependent enzyme and a supply of NAD(P); and a multilayered membrane that overcoats at least a part of the sensing layer and is permeable to an analyte, wherein the membrane comprises at least one layer of negatively charged polymer. The present disclosure also provides methods of using such analyte sensors for detecting one or more analytes preset in a biological sample and methods of manufacturing the analyte sensors.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
G01N 27/31 - Half-cells with permeable membranes, e.g. semi-porous or perm-selective membranes
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
63.
Display screen or portion thereof with graphical user interface
A dose monitoring system for an injection pen includes a dose detection assembly and an injection detection assembly. The dose detection assembly includes a housing securable to a body of the injection pen over a dose display window, an optical sensor assembly for determining an amount of movement of a dose indicator surface within the dose display window, and a processor arranged within the housing. The injection detection assembly includes a housing securable to a dose knob of the injection pen, an injection sensor for detecting a force or touch applied to the dose knob, and a transmitter to communicate injection information when the force or touch is applied. The amount of medication injected is determined based on the amount of movement of the dose indicator surface within the dose display window when the force or touch is applied to the dose knob.
Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors may feature enhancements to address signals obtained from interferent species. Some analyte sensors may comprise a substrate having a planar surface, a working electrode disposed on the surface of the substrate and comprising an active area, the active area having an analyte-responsive enzyme, a reference electrode disposed on the surface of the substrate and separated by a distance from the working electrode, and at least one barrier disposed between the working electrode and the reference electrode, wherein the barrier includes an ablated zone and is configured to electrically isolate the working electrode from the reference electrode, and wherein the working electrode and the reference electrode are electrically isolated from each other on the surface of the substrate.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
Methods, devices, and systems includes an analyte sensor configured to monitor an analyte level, where at least a portion of the analyte sensor is configured to be positioned in contact with a bodily fluid of a subject. The analyte sensor may also include a communication module. A first receiver device may be wirelessly coupled to the communication module of the analyte sensor and configured to receive analyte data from the analyte sensor. One or more second receiver devices may be wirelessly coupled to the communication module of the analyte sensor. The analyte sensor, the first receiver device, and the one or more second receiver devices may be arranged in a star network topology with the analyte sensor being at a center of the star network topology.
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
H04L 67/00 - Network arrangements or protocols for supporting network services or applications
An applicator may include a housing made of a uniform synthetic material. The applicator may include a sharp carrier coupled to a sharp, the sharp carrier also being made of the uniform synthetic material. The applicator may include a retraction spring that is also made of the uniform synthetic material. The applicator may include a sheath that is also made of the uniform synthetic material. The applicator may include a firing pin that is also made of the uniform synthetic material. The applicator may include a drive spring made that is also made of the uniform synthetic material. The applicator may include a puck carrier that is also made of the uniform synthetic material. The applicator may include the glucose sensor.
Methods, devices, and systems includes an analyte sensor configured to monitor an analyte level, where at least a portion of the analyte sensor is configured to be positioned in contact with a bodily fluid of a subject. The analyte sensor may also include a communication module. A first receiver device may be wirelessly coupled to the communication module of the analyte sensor and configured to receive analyte data from the analyte sensor. One or more second receiver devices may be wirelessly coupled to the communication module of the analyte sensor. The analyte sensor, the first receiver device, and the one or more second receiver devices may be arranged in a star network topology with the analyte sensor being at a center of the star network topology.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A63B 24/00 - Electric or electronic controls for exercising apparatus of groups
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
71.
METHODS, DEVICES, AND SYSTEMS FOR ADJUSTING LABORATORY HBA1C VALUES
A method for determining a time for obtaining laboratory glycated hemoglobin measurements can include receiving at least one glucose level for a subject during at least one time period, receiving a first measured glycated hemoglobin (HbAlc) level for the subject corresponding to a beginning of a first time period of the at least one time period, determining a first calculated glycated hemoglobin (HbAlc) level corresponding to the first time period, determining for the first time period a second calculated glycated hemoglobin (HbAlc) level using a first offset value, determining for the first time period a third calculated glycated hemoglobin (HbAlc) level using a second offset value, calculating a first difference between the first calculated glycated hemoglobin (HbAlc) level and the second calculated glycated hemoglobin (HbAlc) level, calculating a second difference between the first calculated glycated hemoglobin (HbAlc) level and the third calculated glycated hemoglobin (HbAlc) level, and generating an alert notification to obtain a second measured glycated hemoglobin (HbAlc) level for the subject in response to a determination that the first difference or the second difference is above a first predetermined threshold value.
A system includes an analyte measurement system and a software application operatively coupled to the analyte measurement system. The analyte measurement system is configured to measure a ketone level in the bodily fluid of a patient. The application is configured to display at least one of (1) a current ketone level and an indicator of a current ketone trend, (2) a ketone trend graph, and (3) a total amount of time that the ketone levels are above at least one predetermined threshold level. The application is also configured to determine if the current ketone level is above the at least one predetermined threshold level, and in response to determining that the current ketone level is above the at least one predetermined threshold level, output an alarm, wherein the alarm is outputted periodically while the current ketone level is above the at least one predetermined threshold level.
Presented herein is a handheld analyte measurement device. The analyte measurement device includes one or more software applications to help the user manager their diabetes. Embodiments and descriptions of the various applications are provided below in conjunction with the handheld analyte measurement device.
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
74.
SYSTEMS, DEVICES, AND METHODS FOR ANALYTE MONITORING AND BENEFITS THEREOF
A method of treatment of a type 2 diabetic patient includes selecting a type 2 diabetic patient having a predetermined comorbidity for treatment, initiating a continuous glucose monitor regimen for the selected type 2 diabetic patient, wherein after six months of initiation of the continuous glucose monitor regimen, a rate of hospitalization for a predetermined diagnostic category of the selected patient having the predetermined comorbidity is reduced by at least 12% relative to an average rate of hospitalization for the predetermined diagnostic category of selected patients having the predetermined comorbidity without the continuous glucose monitor regimen.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
75.
METHOD FOR MANAGING A PHYSICAL LAYER UTILIZED DURING A WIRELESS CONNECTION WITH MEDICAL DEVICES
Techniques include a medical device including processors, one or more sensors configured to generate signals corresponding to one or more physiological signals detected in a body of a user, a communication module configured to communicate wirelessly with a receiving device using a communication protocol capable of data transmission or reception at multiple data rates, and memories including instructions to cause the one or more processors to transmit information to the receiving device indicating that the communication module is configured to communicate using the multiple data rates; determine one of the data rates to be utilized for at least one of data transmission or reception during a communication session with the receiving device; initialize the communication session with the receiving device using the determined data rate; and transmit, via to the receiving device and using the determined data rate, communications based on the signals corresponding to the physiological signals.
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
A61N 1/372 - Arrangements in connection with the implantation of stimulators
A61N 1/375 - Constructional arrangements, e.g. casings
The present disclosure describes lactate-responsive sensors having first and second lactate-responsive sensing areas, sensing systems incorporating the lactate-responsive sensor, and methods of using the same that for continuously monitoring lactate levels and determining variance between lactate concentrations derived from signals independently obtained from the first and second lactate-responsive areas.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
77.
DEPLOYMENT AND USE OF A CONTINUOUS ANALYTE MONITORING SYSTEM FOR IMPROVED PATIENT TREATMENT
Disclosed herein are system, method, and computer program product embodiments for improving detection and treatment of patient conditions based on continuous analyte data. The disclosed techniques utilize analyte data, such as lactate, glucose, and creatinine, provided from a continuous analyte sensor to predict patient outcomes. The prediction may also take into account other medical information associated with the patient, such as patient vital signs and medical history. The disclosed system allows for early and non-invasive prediction of patient outcomes in various settings including a hospital setting, a home setting, disease (e.g., heart failure, sepsis) detection, and high risk surgery monitoring. The disclosed system also is configured to monitor patient conditions and generating alerts and/or notifications based on the predicted patient outcomes to provide preemptive treatment of patient conditions.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
78.
DEPLOYMENT AND USE OF A CONTINUOUS ANALYTE MONITORING SYSTEM FOR IMPROVED PATIENT TREATMENT
Disclosed herein are system, method, and computer program product embodiments for improving detection and treatment of patient conditions based on continuous analyte data. The disclosed techniques utilize analyte data, such as lactate, glucose, and creatinine, provided from a continuous analyte sensor to predict patient outcomes. The prediction may also take into account other medical information associated with the patient, such as patient vital signs and medical history. The disclosed system allows for early and non-invasive prediction of patient outcomes in various settings including a hospital setting, a home setting, disease (e.g., heart failure, sepsis) detection, and high risk surgery monitoring. The disclosed system also is configured to monitor patient conditions and generating alerts and/or notifications based on the predicted patient outcomes to provide preemptive treatment of patient conditions.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
79.
ANALYTE MONITORING SYSTEMS AND METHODS FOR MONITORING MULTIPLE ANALYTES
An analyte monitoring assembly for monitoring one or more analytes in a bodily fluid of a user includes a housing configured to be mounted on a body of a user and sensor electronics arranged within the housing. An analyte sensor includes a body portion coupled to the sensor electronics and arranged within the housing and one or more tail portions configured to be positioned in the body of the user. The analyte sensor further includes a first electrode comprising a first active area for detecting a first analyte, and a second electrode comprising a second active area for detecting a second analyte.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
80.
SENSOR FOR DETECTING GLUCOSE AND LACTATE AND METHODS FOR DETERMINING AEROBIC AND ANAEROBIC THRESHOLDS
The present disclosure describes lactate-responsive sensors, sensing systems incorporating a lactate-responsive sensor, and methods of use thereof that would be beneficial for continuously monitoring lactate levels and determining lactate thresholds (both aerobic and anaerobic thresholds). The present disclosure also relates to an analyte sensor for continuously detecting glucose and lactate levels.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
81.
ANALYTE MONITORING SYSTEMS AND METHODS FOR MONITORING MULTIPLE ANALYTES
An analyte monitoring assembly for monitoring one or more analytes in a bodily fluid of a user includes a housing configured to be mounted on a body of a user and sensor electronics arranged within the housing. An analyte sensor includes a body portion coupled to the sensor electronics and arranged within the housing and one or more tail portions configured to be positioned in the body of the user. The analyte sensor further includes a first electrode comprising a first active area for detecting a first analyte, and a second electrode comprising a second active area for detecting a second analyte.
A lactate-responsive enzyme may form the basis for lactate detection and quantification using an electrochemical analyte sensor. Various features may be incorporated within an analyte sensor containing a lactate-responsive enzyme, particularly lactate oxidase, to improve sensitivity and response stability of the analyte sensor. Such analyte sensors may comprise: a working electrode having an active area disposed thereon, and a mass transport limiting membrane overcoating at least the active area upon the working electrode. The active area comprises at least a polymer, an albumin, and a lactate-responsive enzyme that is covalently bonded to the polymer. The mass transport limiting membrane may comprise at least a crosslinked polyvinylpyridine homopolymer or copolymer. The analyte sensors may determine a lactate concentration in a biological fluid, particularly in vivo, which may be correlated to various physiological conditions.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A glucose monitoring system comprising a sensor control device comprising an analyte sensor coupled with sensor electronics, the sensor control device configured to transmit data indicative of an analyte level of a subject, and a reader device. The reader device comprises a wireless communication circuitry configured to receive the data indicative of the analyte level and a glycated hemoglobin level for the subject, a non-transitory memory, and at least one processor communicatively coupled to the non-transitory memory and the analyte sensor and configured: calculate a plurality of personalized glucose metrics for the subject using at least one physiological parameter and at least one of the received data indicative of the analyte level or the received glycated hemoglobin level, and a display, on a display of the reader device, a report comprising a plurality of interfaces including at least two or more of the received data indicative of the analyte level, the received glycated hemoglobin level, or the calculated plurality of personalized glucose metrics, wherein the plurality of interfaces comprising the report are based on a user type.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
85.
ANALYTE MONITORING: STABILIZER FOR SUBCUTANEOUS GLUCOSE SENSOR WITH INCORPORATED ANTIGLYCOLYTIC AGENT
An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
86.
PREDICTING ANALYTE LEVELS BASED ON INTERMITTENT SENSOR DATA
Techniques for predicting analyte levels based on intermittent sensor data are disclosed. First sensor data is acquired from an analyte sensor. The first sensor data reflects analyte levels of a user who is wearing the analyte sensor. The first sensor data is collected over a first time period. Later, a determination is made as to whether data is still being acquired from the analyte sensor. As a result of determining that data is no longer being acquired from the analyte sensor, the first sensor data is classified as intermittent analyte data. The intermittent analyte data is then used to generate predicted analyte level data for the user during a second time period that is subsequent to the first time period. The predicted analyte level data is reflective of the intermittent analyte data.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
87.
Display screen or portion thereof with graphical user interface
Techniques for predicting analyte levels based on intermittent sensor data are disclosed. First sensor data is acquired from an analyte sensor. The first sensor data reflects analyte levels of a user who is wearing the analyte sensor. The first sensor data is collected over a first time period. Later, a determination is made as to whether data is still being acquired from the analyte sensor. As a result of determining that data is no longer being acquired from the analyte sensor, the first sensor data is classified as intermittent analyte data. The intermittent analyte data is then used to generate predicted analyte level data for the user during a second time period that is subsequent to the first time period. The predicted analyte level data is reflective of the intermittent analyte data.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
89.
BACKGROUND INTERFERENCE MITIGATION FOR HIGH SENSITIVITY KETONE SENSING BY ACCUMULATION MODE SENSING AT LOW WORKING ELECTRODE POTENTIAL
The present disclosure relates to a method of improving the sensitivity of sensing ketones that includes providing i) a ketone sensing electrode comprising a ketone-responsive enzyme and a redox mediator; and ii) a background sensing electrode comprising a redox mediator and no ketone-responsive enzyme and applying a potential less than +40 mV to provide a steady state. The ketone sensing electrode and background sensing electrode can be simultaneously or sequentially disconnected from the circuit to allow the charge to accumulate for a set period of time. After sufficient charge has been built up, both electrodes can be reconnected to the circuit. The ketone signal can be measured by subtracting a signal obtained from the background sensing electrode from a signal obtained from the ketone sensing electrode. The present disclosure further relates to a ketone sensor comprising a first sensing electrode that senses ketone and a second sensing electrode that senses the background.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/32 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase involving dehydrogenase
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
The present disclosure relates to a creatinine sensor comprising a first working electrode, a creatinine sensing layer on the first working electrode comprising a redox mediator, creatinine amidohydrolase, creatine amidinohydrolase, and sarcosine oxidase, and a hydrophilic polyurethane membrane overcoating the creatinine sensing layer. The creatinine sensor can further comprise a background sensing electrode that does not detect creatinine. The present disclosure further relates to a method for sensing creatinine comprising exposing the creatinine sensor with a background sensing electrode to a fluid; applying a potential to the first and second working electrodes; obtaining a first signal from the first working electrode proportional to a concentration of creatinine and background interference in the fluid; obtaining a second signal from the second working electrode proportional to a concentration of background interference in the fluid; and determining the concentration of creatinine in the fluid by subtracting the second signal from the first signal.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
The present disclosure relates to a creatinine sensor comprising a first working electrode, a creatinine sensing layer on the first working electrode comprising a redox mediator, creatinine amidohydrolase, creatine amidinohydrolase, and sarcosine oxidase, and a hydrophilic polyurethane membrane overcoating the creatinine sensing layer. The creatinine sensor can further comprise a background sensing electrode that does not detect creatinine. The present disclosure further relates to a method for sensing creatinine comprising exposing the creatinine sensor with a background sensing electrode to a fluid; applying a potential to the first and second working electrodes; obtaining a first signal from the first working electrode proportional to a concentration of creatinine and background interference in the fluid; obtaining a second signal from the second working electrode proportional to a concentration of background interference in the fluid; and determining the concentration of creatinine in the fluid by subtracting the second signal from the first signal.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
92.
METHODS AND APPARATUSES FOR PROVIDING ADVERSE CONDITION NOTIFICATION WITH ENHANCED WIRELESS COMMUNICATION RANGE IN ANALYTE MONITORING SYSTEMS
Methods, devices, systems, and kits are provided that buffer the time spaced glucose signals in a memory, and when a request for real time glucose level information is detected, transmit the buffered glucose signals and real time monitored glucose level information to a remotely located device, process a subset of the received glucose signals to identify a predetermined number of consecutive glucose data points indicating an adverse condition such as an impending hypoglycemic condition, confirm the adverse condition based on comparison of the predetermined number of consecutive glucose data points to a stored glucose data profile associated with the adverse condition, where confirming the adverse condition includes generating a notification signal when the impending hypoglycemic condition is confirmed, and activate a radio frequency (RF) communication module to wirelessly transmit the generated notification signal to the remotely located device only when the notification signal is generated.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
93.
SYSTEMS, DEVICES, AND METHODS OF USING BLOCKCHAIN FOR TRACKING PATIENT IDENTIFICATION
A system for bi-directional communication of patient data can include a first database having a first record including first data associated with a personal identification of a patient, a second database having a second record including second data associated with a user identification of the patient; and one or more processors configured to: pair the first data and the second data based upon a shared data item contained in the first record and the second record, and display a combination of the first data paired with the second data. A blockchain is used to paid the first and second records associated with different user identifications of the same patient.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user. The in vivo analyte sensor is coupled to an electronics unit holding a memory with instruction to cause processing circuitry to initiate a predetermined time period that is longer than a predetermined life of the sensor, during the predetermined time period, convert signals from the sensor related to glucose to respective corresponding glucose levels, without relying on any post-manufacture independent analyte measurements from a reference device, and at the expiration of the predetermined time period, disable, deactivate, or cease use of one or more feature.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
G01N 33/487 - Physical analysis of biological material of liquid biological material
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
95.
Display screen or portion thereof with graphical user interface
