Various embodiments include an ion source assembly. The ion source assembly may include an oven configured to receive a charge material through an upstream end, an ionization reaction volume adjacent a downstream end of the oven that may be configured to receive a neutral gas, a cathode assembly positioned to generate an electron beam directed toward the ionization reaction volume, and an anode positioned downstream of the ionization reaction volume. The ionization reaction volume may be disposed between the oven and the cathode assembly. The electron beam may flow in a direction opposite to a flow of ions generated in the ionization reaction volume.
Various embodiments include a system for isotope separation. The system may include an ion source assembly configured to generate ions from a source material, an injector assembly positioned to receive, accelerate, and focus the ions into a beam, and a separator assembly positioned to receive ions from the injector assembly. The separator assembly may include a velocity filter with a magnet assembly and two electrodes with curved portions angled to vary the electric field to compensate for non-linearities in the magnetic field. The system may also include a collimator coupled to a distal end of a drift path portion, the collimator comprising a first slit aperture. An isotope collector module comprising a first removable collection surface may be positioned beyond the collimator to receive the first target isotope ions.
G21G 1/10 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes outside of nuclear reactors or particle accelerators by bombardment with electrically-charged particles
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
3.
PRODUCTION AND PURIFICATION OF LUTETIUM-177 USING ELECTROMAGNETIC SEPARATION AND CHROMATOGRAPHY
Various embodiments include a method of producing purified lutetium-177. The method may include irradiating a target material containing lutetium-176 in a nuclear reactor, separating lutetium-177 from the irradiated target material using electromagnetic isotope separation, dissolving the separated lutetium-177 in an acidic solution, purifying the dissolved lutetium-177 using a series of chromatographic columns and ion resins, and eluting the purified lutetium-177 in a final chemical form suitable for medical use. The chromatographic columns may include a first column containing a lanthanide resin and a second column containing a diglycolamide resin. The final chemical form may be lutetium-177 chloride.
G21G 1/02 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes in nuclear reactors
B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
C01F 17/13 - Preparation or treatment, e.g. separation or purification by using ion exchange resins, e.g. chelate resins
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
An isotope generation apparatus is disclosed including: an ion beam source of any of the types described herein; an extractor for extracting the ion beam from the confinement region, where the beam includes a portion of multiply ionized ions in a selected final ionization state; a target including a target material; and an accelerator for accelerating the ion beam and directing the ion beam to the target. The ion beam directed to the target transmutes at least a portion of the target material to a radio-isotope in response to a nuclear reaction between ions in the selected final ion state and atoms of the target material.
H05H 1/02 - Arrangements for confining plasma by electric or magnetic fieldsArrangements for heating plasma
H05H 1/14 - Arrangements for confining plasma by electric or magnetic fieldsArrangements for heating plasma using applied magnetic fields only wherein the containment vessel is straight and has magnetic mirrors
G21G 1/10 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes outside of nuclear reactors or particle accelerators by bombardment with electrically-charged particles
An ion source is disclosed including: a chamber disposed about a longitudinal axis and containing a gas, a magnetic confinement system configured to produce a magnetic field in a confinement region within the chamber, an electron cyclotron resonance driver which produces a time varying electric field which drives the cyclotron motion of electrons located within the confinement region, the driven electrons interacting with the gas to form a confined plasma. During operation, the magnetic confinement system confines the plasma in the confinement region such that a portion of atoms in the plasma experience multiple ionizing interactions with the driven electrons to form multiply ionized ions having a selected final ionization state.
