The invention relates to an in-tube check valve (1) which is inserted in a tube (13) for or is insertable in a tube for fluid flow. The check valve comprises a stator (12), an adjustment part (11), a closure element (16), and a spring (17). The stator comprises an inlet (14) and a valve seat (15) and the adjustment part comprises an outlet (18) and an external thread (21). The external thread is arranged to engage with the inner wall (22) of the tube, and the adjustment part (11) and the stator are placeable with an operational distance (25) between them, and said operational distance is adjustable by reversible screwing the adjustment part into the tube facilitated by the external thread's engagement with the inner wall of the tube.
F16K 15/04 - Check valves with guided rigid valve members shaped as balls
F16K 17/04 - Safety valvesEqualising valves opening on surplus pressure on one sideSafety valvesEqualising valves closing on insufficient pressure on one side spring-loaded
F16K 27/02 - Construction of housingsUse of materials therefor of lift valves
2.
NICKEL/SUPPORT - TERNARY EUTECTIC SALT CATALYST, USE THEREOF AND METHODS OF MANUFACTURE
The present invention relates to novel catalyst materials including use thereof in catalytic transformations, such as in methods of producing syngas from mixtures of methane and carbon dioxide. The present invention further relates also to use of such novel catalysts in methods of improving operando life-time of a heterogenous catalyst comprising at least one active surface prone to carbon deposition and deactivation.
The present invention relates to the field of PCR amplification and uses thereof, and specifically relates to leaping PCR reactions, where only a fraction of a target nucleic acid is amplified in the PCR reactions, wherein the PCR reaction produces an amplification product which comprises the terminal parts of a target nucleic acid but is devoid of a central part of the target nucleic acid.
The invention relates to a hemoglobin-based oxygen carrier where the carrier has a metal-organic framework to entrap hemoglobin and is provided as nanoparticles; as well as a method for preparing the nanoparticles. The invention further relates to a pharmaceutical comprising the hemoglobin-based oxygen carrier.
Various strategies can be used to address dendrite formation in zinc batteries, spanning from advanced electrode materials to optimized operating conditions. Addressing dendrite challenges is pivotal for bolstering safety in metal-based batteries. The invention relates to an electrolyte specifically designed to limit5 dendrite formation in Zn/Mg batteries providing a safer and more reliable metal or metal/air battery.
The present invention relates to a process for degradation of per- and polyfluoroalkyl substances (PFAS) in aqueous solutions using UV light and short-chain carboxylic acid additives. The process provides an advantage in being efficient, fast and environmentally sound, producing no complex hazardous bybroducts.
Methods are disclosed for heat treating a high-carbon steel component, including a high-carbon tool- steel component, printed by powder-based full-melt additive manufacturing, wherein the printed component contains at least 0.2 wt% C and comprises at least 30 vol% of an austenitic phase and wherein the composition of the component may be selected according to a modified Schaeffler diagram. The methods comprise applying a thermal treatment to decompose at least a fraction of the austenitic phase into at least a ferritic phase, austenitization, rapid cooling or quenching to a temperature below which austenite transforms to martensite, and tempering.
An electromechanically auxetic structural element defined by the application of coated electrodes on the larger two main surfaces encompassing the triply periodic minimal surface structures made of active materials that deform under the actuation of electrical fields. A structural element (10) comprising a base structure (11) defined by a triply periodic minimal surface having a thickness and two main surfaces that separated two disjoint sub-volumes (12, 14), wherein the base structure is made of an electromechanically functional material, wherein the surface (12') of the first sub-volume comprises a first coating of a first electrically conductive material (16), wherein the surface (14') of the second sub-volume comprises a second coating of a second electrically conductive material (16), and wherein the coating of the first sub-volume is arranged to not be in electrical contact with the coating of the second sub-volume. This structural element can fill any 3D-shaped volume, imparting an auxetic electromechanical response to the overall device (sensor, actuator or transducer).
Disclosed is a molecular sensor for detecting molecules dissolved in liquid, the molecular sensor comprising: a sensor housing, a measurement chamber comprised in the sensor housing and being fluidly coupled to an exterior of the sensor housing, and a quartz crystal microbalance (QCM). A quartz crystal resonator comprised in the QCM is functionalised with a metal-organic framework (MOF) which can reversibly adsorb methane and/or reversibly adsorb carbon dioxide, and the molecular sensor is configured such that liquid which enters the measurement chamber can come in direct contact with a surface of the MOF. Also disclosed is a method of detecting and/or quantifying molecules dissolved in a liquid, the method comprising the steps of: providing a molecular sensor comprising a quartz crystal microbalance (QCM), the QCM comprising a quartz crystal resonator, the QCM being functionalised with a metal-organic framework (MOF) which can reversibly adsorb methane and/or reversibly adsorb carbon dioxide; providing the liquid to a functionalised surface of the QCM such that the liquid directly contacts the functionalised surface.
The present disclosure relates to an optical system for determining at least one parameter of at least one particle. The system comprises a first light beam and a second light beam, a modulator, a sample carrier, one or more light detectors, and a data processing means. The modulator is arranged along a path of the first light beam and configured to modulate the first light beam. The sample carrier containing the at least one particle to be analyzed and arranged so that at least part of the sample with the at least one particle is provided at an interrogation region. The modulated first light beam and the second light beam are arranged to intersect with each other at the interrogation region and to form an interference pattern thereto. The sample with particles and the interference pattern are configured to move with respect to each other. The one or more light detectors are configured to detect an output signal scattered and/or emitted from the at least one particle being transported by the sample carrier and also being configured to deliver an electrical signal to the data processing means based on this output signal. The data processing means being configured to determine said at least one parameter of the at least one particle from the received electrical signal.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
A computer-implemented method and computer-system for optimizing the design of a physical thermal energy transfer channel. The process involves defining a unit cell based on target design criteria, and then using these unit cells to form the channel. The optimization is performed at the unit cell level, focusing on improving thermal performance through iterative material redistribution within the cell. The optimized design parameters for the unit cell is output and used to manufacture the optimized thermal energy transfer channel with a specified arrangement of these unit cells as a physical object, based thereon.
G06F 30/28 - Design optimisation, verification or simulation using fluid dynamics, e.g. using Navier-Stokes equations or computational fluid dynamics [CFD]
The disclosure regards an unmanned aerial vehicle (UAV) comprising a main body, a frame, a plurality of propeller units attached to the frame, and a displacement mechanism configured to displace with three translational degrees of freedom the main body of the UAV with respect to the frame, thereby adjusting the center of mass of the 5 UAV in any spatial direction.
The disclosure regards a computer implemented method for estimating the reactivity of dissolved organic matter in a liquid comprising the steps of obtaining a first fluorescence measurement from the liquid, wherein the first fluorescence measurement comprises a first emission wavelength and a first excitation wavelength, obtaining a second fluorescence measurement from the liquid, wherein the second fluorescence measurement comprises a second emission wavelength and a second excitation wavelength, determining a sample photosensitivity index based on the first fluorescence measurement, the second fluorescence measurement and a conversion factor specific to said liquid, and estimating the reactivity of dissolved organic matter in the liquid based on the sample photosensitivity index, wherein the conversion factor is a correlation between a series of base photosensitivity indexes and a series of fluorescence measurement ratios, obtained from a liquid of a same type as the liquid. The present disclosure further relates to a computer implemented method for calibrating a fluorescence setup in relation to a liquid, and to an optical measurement system for estimating the reactivity of dissolved organic matter in a liquid.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
The invention relates to a series of novel polymers that are stable in highly alkaline media while at the same time able to conduct ions under such conditions. The present invention further relates to use of such polymers in the preparation of membranes that find use in alkaline water electrolysers.
The present invention relates to the use of compositions comprising 4-hydroxyphenyllactic acid for the prevention and/or treatment of IgE-mediated diseases.
The invention relates self-polishing anti-fouling coating composition comprising a) a self-polishing binder, b) particles of a copper compound and/or a zinc compound; c) optionally a biocide, wherein the mean particle diameter of the copper compound and zinc compound is in the range of from 2 to 100 nm, preferably 5 to 50 nm such as in the range of from 8 to 40 nm, preferably in the range of from 10 - 30 nm, 12 - 25 nm, 14 - 20 nm, or 16 - 18 nm; and a coating made thereof.
C12P 17/18 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
The invention relates to a method for analyzing a first component of a fluid sample also comprising a second component where the sample is stepwise introduced further and further along a substrate and finally removed from at least the last wetted portion of the substrate. The analysis is performed at the last wetted portion of the substrate.
The present invention relates to a method for estimating or determining fitness of enzyme variants and/or optimizing a nucleotide sequence encoding an enzyme variant comprising generating a DNA variant library and linking a unique DNA barcode to each DNA variant, wherein the DNA variants are subjected to long-read and short-read sequencing. In particular, the present invention relates to a method for predicting or determining fitness of enzyme variants and/or optimizing a nucleotide sequence encoding an enzyme variant by combining DNA barcodes, selection pressure, long-read sequencing, and short-read sequencing. Furthermore, the present invention relates to application of machine learning for predicting enzyme fitness and/or optimizing a nucleotide sequence encoding an enzyme variant based on data obtained from said method.
The present disclosure relates to methods for production of phosphorylated recombinant animal proteins, phosphorylated phosphomimetic animal proteinsand phosphomimetic animal proteins, as well as the use of such animal proteins.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
21.
A METHOD OF, AND APPARATUS FOR, IMPROVED ESTIMATION OF FETAL CHARACTERISTICS
in uteroin utero; b) utilising the image data in a first machine learning model comprising one or more neural networks to generate one or more latent space representations of the anatomical structure and appearance of the fetus and one or more predicted measurements of the anatomical structure of the fetus; and c) utilising the one or more predicted measurements and the one or more latent space representations in a second machine learning model to generate an estimated weight of the fetus.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
22.
AN IMPROVED METHOD OF, AND APPARATUS FOR, ULTRASOUND EXAMINATION TO EXTRACT FETAL CHARACTERISTICS
There is provided a method of performing ultrasound examination of a fetus in utero, the method comprising the steps of: a) acquiring a plurality of ultrasound images of the fetus in utero using an ultrasound imaging apparatus, the ultrasound images comprising image data representative of the anatomical structure and appearance of a head, an abdomen and a femur of a fetus in utero; b) utilising, on a computing system, a plurality of sets of the ultrasound images in an ensemble machine learning model comprising one or more neural networks to determine an estimated fetal weight and generate an associated uncertainty estimate for the estimated fetal weight; c) providing, based on the uncertainty estimate, a notification to the operator of the ultrasound imaging apparatus in respect of one or more parameters indicative of the accuracy of one or more of the obtained ultrasound images.
The present disclosure relates to a multilayered gel pad comprising a first layer having a first surface that is non-adherent to patient tissue; and a second layer having a second surface that is adapted to be adherent to a target surface; wherein the first and second surface are on opposite outer sides of the gel pad and wherein the first layer is self-healing to the second layer.
The present invention relates to a polymer-based drug delivery system as such and its use in a method of treatment of a range of diseases and disorders, including cancer. The drug delivery system of the present invention is suitable for intracranial delivery and release of cytotoxic agents, in particular radioisotope-functionalized agents such as deoxyuridine.
A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
25.
NANOPARTICLE DRUG DELIVERY SYSTEM FOR RADIOTHERAPY IN THE BRAIN
The invention relates to the field of drug delivery of radioactive nucleosides for radiotherapy in the brain. The invention provides a composition comprising a prodrug of a radioactive Auger electron-emitting radionucleoside and a nanoparticle carrier, suitable for use in the treatment of brain tumors.
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
27.
MICROPUMP WITH ELECTROSTRICTIVE MATERIAL ACTUATION
>n nnn n to generate a wave travelling of amplitude S along the capillary tube section. The micro-pump can be configured to operate as a travelling wave micro-pump (TWµP) by adjusting the driving signal so that 2S < 0,2h or to operate as a peristaltic micro-pump (PµP) by adjusting the driving signal so that 2S = 0,5h.
METHOD FOR DESIGNING GEOMETRICALLY FITTING AND STRUCTURALLY OPTIMIZED PATIENT-SPECIFIC IMPLANT MODELS AND METHOD FOR TRAINING AN ARTIFICIAL INTELLIGENCE MODEL FOR DESIGNING GEOMETRICALLY FITTING AND STRUCTURALLY OPTIMIZED PATIENT-SPECIFIC IMPLANT MODELS
The present invention relates to a computer-implemented method (100) for designing a geometrically fitting and structurally optimized patient-specific implant model (1) in view of its manufacturing.
The present invention relates to an unmanned aerial vehicle comprising, a vehicle body; a plurality of rotors, each rotor having a rotational axis; and pivotal rotor couplings configured to facilitate pivotal adjustment of an orientation of the rotational axis of a respective rotor around a respective pivot axis. The vehicle has a UAV configuration in which the rotational axis of each rotor has an upright orientation, and a USV configuration in which the rotational axis of at least some rotors has a non-upright orientation. The vehicle is configured to be switched between the UAV configuration and the USV configuration via the pivotal rotor couplings. The plurality of rotors is located above a water surface when the vehicle floats on water in the USV configuration. At least some rotors have different horizontal orientations in the USV configuration. The invention further relates to a method of operating such a vehicle.
The present invention relates in one aspect to an absorption spectroscopy apparatus for measuring one or more gases in an atmosphere, wherein the apparatus comprises: a tunable laser source configured to emit laser radiation; an optical system for transmitting the emitted laser radiation as a probe laser beam, and for collecting return light, in particular emitted laser radiation reflected by a remote surface, the optical system defining one or more apertures; a photodetector for detecting the collected return light, wherein the apparatus defines a transmission beam path between the tunable laser source and a transmission aperture of said at least one apertures, and the apparatus defining a receiving beam path between a receiving aperture of said at least one aperture and the photodetector; wherein the optical system is configured to have a polarization-insensitive transmittance.
G01N 21/39 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
31.
INVARIANT NATURAL KILLER T CELL-ACTIVATING VACCINE AGAINST BACTERIAL INFECTIONS
Provided are vaccine compositions comprising a liposome, a bacterial polysaccharide antigen, and an invariant natural killer T (iNKT) cell agonist, methods of treating or preventing a bacterial infection using the compositions, and nasal spray devices comprising them.
The present invention relates to glycoengineered extracellular vesicles, as well as methods of production of such glycoengineered extracellular vesicles, methods of glycoengineering extracellular vesicles, and uses of glycoengineered extracellular vesicles.
The invention relates to a monoclonal binding agent comprising complementary determining regions CDR1, CDR2, and CDR3 of a single domain antibody (sdAb), the monoclonal binding agent being able to bind and/or block and/or neutralise Elapidae three-finger toxins (3FTx) of multiple snake species, wherein the monoclonal binding agent is selected from an antibody, an antibody format, an antibody fragment or an antibody analogue.
A kirigami device (1) comprising a foldable substrate (9), the substrate comprising: one or more discontinuous cuts (6) arranged such that the substrate may be moved from a planar configuration wherein the substrate extends substantially in a first plane, to an interlocking configuration wherein the substrate forms an expanded structure extending in three dimensions; and an interlocking mechanism comprising a first component and a second component, wherein the first component is disengaged from the second component in the planar configuration, and wherein the first component is engaged with the second component in the interlocking configuration, wherein the interlocking mechanism is arranged to retain the substrate in the interlocking configuration
C04B 35/524 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbon, e.g. graphite obtained from polymer precursors, e.g. glass-like carbon material
H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
The present invention concerns enzymatic synthesis of glycosides of anthranilate derivatives, such as methyl anthranilate N-glucoside, ethyl anthranilate N-glucoside, and butyl anthranilate N-glucoside. These anthranilate derivatives may preferably be used as insect and/or bird repellent.
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
A01N 33/06 - Nitrogen directly attached to an aromatic ring system
A01N 33/10 - AminesQuaternary ammonium compounds containing oxygen or sulfur having at least one oxygen or sulfur atom directly attached to an aromatic ring system
The invention relates to a method of differentiating immature cells to a specific cell lineage of interest and/or to a specific cell type, said method comprising: i) Silicificating cells of said specific cell lineage to obtain silicified cells; ii) Calcinating a plurality of the silicified cells to obtain a scaffold; iii) Contacting the scaffold with the immature cells; iv) Culturing the immature cells in contact with the scaffold in a culture medium, thereby inducing differentiation of the immature cells into differentiated cells of said specific cell lineage and/or of said specific cell type. The invention also relates to scaffolds, silicified cells and kits for the differentiation of cells.
A method for preparing an adhesive, said method comprising - providing catechol substituted chitosan in an aqueous solution with a pH in the range of pH 3-5, - admixing said aqueous solution with a salt to obtain a polymer-rich phase and a polymer-poor phase; and - isolating the polymer-rich phase to obtain said adhesive. Described is also an adhesive obtainable from said method and uses thereof.
The invention relates to a modified encapsulin nano-particle carrier for cell-targeted delivery of one or more therapeutic agent to a mammalian cell, wherein the agent may be a nucleic acid and/or protein capable of modulating the genome and/or modulating the expression of one or more native or non-native genes within said targeted cell. The nano-particles are composed of fusion polypeptides that are capable of binding and encapsulating a cargo of therapeutic agent, as well as cell-specific and intracellular delivery of the cargo to a target mammalian cell.
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
C12N 15/62 - DNA sequences coding for fusion proteins
40.
A BIOCATALYTIC ROUTE TO INDOLE, AND OPTIONALLY INDICAN AND/OR INDIGO
The present invention concerns in vitro enzyme biosynthesis of indole, and optionally further production conversion of the indole to indican and/or indigo; preferably provided as a one-pot solution.
C12P 17/16 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing two or more hetero rings
C12P 19/60 - Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
The disclosure regards a method for additive manufacturing an object, comprising the steps of providing a first radiation source emitting a first radiation; providing a container containing the photocurable resin curable by the first radiation, the container comprising a wall transparent or at least semi-transparent to at least a part of the first radiation; providing a second radiation source, wherein the photocurable resin is non-curable by said second radiation source; determining at least one property of the wall by measuring a second radiation from or reflected by the wall; providing a surface submerged on the container containing the resin; and controlling a set of processing parameters based on the at least one property of the wall for forming at least one layer of an object by curing a part of the photocurable resin on the submerged surface.
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
C07D 209/56 - Ring systems containing three or more rings
C07D 497/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Disclosed is a composition for intumescent coating. The composition comprises a silicon-based binder, an expandable agent, a thixotropic agent, and a silicate filler. The expandable agent is hydrated alkali silicate particles. Furthermore, an intumescent coating system is disclosed. The intumescent coating system comprises a primer, the composition for intumescent coating according to this disclosure, and optionally a top coat. Furthermore, a method for preparing a composition for intumescent coating is disclosed.
Provided are lactic acid bacteria which are deficient in thiamine and which are deficient in lactate dehydrogenase and/or lactate dehydrogenase activity, methods for producing such bacteria, and methods for producing pyruvate by culturing such bacteria in medium deficient in thiamine and under aeration.
C07D 471/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups in which the condensed systems contains four or more hetero rings
G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
C07D 209/56 - Ring systems containing three or more rings
46.
BIOLOGICAL PRODUCTION OF POLYHYDROXYALKANOATES AND MONOMERS THEREFOR USING ENGINEERED PSEUDOMONAS CELLS
The present invention relates to cells and methods for producing polymers from acetate. The invention also relates to cells with increased tolerance to short-chain organic acids, such as acetate. In particular, the invention relates to production of polyhydroxybutyrate (PHB), fluorinated 3-hydroxybutyrate and fluorinated PHB (F-PHB) from acetate and/or F-acetate using bacterial cells with increased tolerance to acetate.
The invention relates to a method for manufacturing a multilayer structure with internal voids, such as monolithic stacks for solid-state electrochemical devices such as batteries, SOFC/SOEC stacks, gas separation devices, etc. The method comprises providing green layers comprising a first binder and enclosing a mold material that fills out an interstice between the layers. The layers are adhered, such as by application of elevated pressure and/or temperature, to form a multilayered structure having a mold-filled interstice with no fluid connections to an outside of the multilayer structure. Thereafter, the multilayer structure is machined to provide a fluid connection between the at least one mold-filled interstice and the outside of the multilayer structure. A viscosity of at least part of the mold material is decreased to allow easy removal of the mold material from the at least one interstice via the fluid connection, thereby forming an internal void in the multilayer structure. The viscosity decrease is induced without initiating a phase change to gas phase in and/or combustion of the first binder, i.e., without initiating de-binding or binder burnout. After removal of the mold material, there are free access to the binder-containing materials inside the structure via the voids and fluid connections, and the multilayer structure can be heat treated to perform binder burnout and sintering without the risk of structural damage.
H01M 8/124 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte
B22F 5/10 - Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product of articles with cavities or holes, not otherwise provided for in the preceding subgroups
B22F 7/02 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting of composite layers
B22F 7/06 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting of composite workpieces or articles from parts, e.g. to form tipped tools
H01M 8/12 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte
48.
IN VIVO NEUTRALIZATION OF CORAL SNAKE VENOMS WITH AN OLIGOCLONAL NANOBODY MIXTURE
222 neurotoxin and short-chain alpha neurotoxin from coral snake venoms. The invention also relates to pharmaceutical compositions, kit of parts and kits for the treatment and diagnosis of snake envenomation.
C12Q 1/18 - Testing for antimicrobial activity of a material
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
A61K 31/00 - Medicinal preparations containing organic active ingredients
50.
A METHOD OF GENERATING SUPERCONTINUUM LIGHT AND A SUPERCONTINUUM LIGHT SOURCE
The invention relates to a method of generating supercontinuum light comprising : providing frequency comb pump light and auxiliary pump light, wherein an auxiliary centre frequency is spectrally detuned with respect to a comb centre frequency by an auxiliary pump detuning; pumping a nonlinear medium associated with dispersive wave generation at a dispersive wave frequency shifted by a dispersive wave detuning relative to the comb centre frequency; spectrally translating the frequency comb pump light via a cascaded four-wave mixing process induced by the auxiliary pump light to thereby generate cascaded comb light; generating a dispersive wave at the dispersive wave frequency, wherein the generation of the dispersive wave is induced by the cascaded comb light due to an integer multiple of the auxiliary pump detuning lying within a spectral range of the dispersive wave detuning; and outputting the cascaded comb light and the dispersive wave to thereby provide the supercontinuum light.
C07C 1/12 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of carbon from carbon dioxide with hydrogen
C07C 29/154 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively with hydrogen or hydrogen-containing gases characterised by the catalyst used containing copper, silver, gold, or compounds thereof
C07C 45/49 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reaction with carbon monoxide
A method for quantitative detection of glucose in a liquid sample using continuous wave (CW) Terahertz (THz) spectroscopy such as THz cross-correlation spectroscopy (CCS) or THz frequency domain spectroscopy (FDS) in an attenuated total reflection (ATR) setup is disclosed. A continuous-wave (CW) light signal is used to generate a THz signal reflecting off an internal face of a sample surface of an ATR element. An electric detection signal resulting from an interference between THz radiation from the sample and the CW light signal can be recorded while a phase or a frequency domain parameter of the CW light signal is adjusted. A spectrum of the electric detection signal as a function of an adjustment of a phase or a frequency domain parameter is recorded while an external face of the sample surface is in contact with a sample comprising a liquid solution of glucose. The recorded spectrum is analysed using a supervised machine learning algorithm trained on similarly recorded spectra from similar liquid solutions with known glucose levels to estimate a glucose level in the liquid solution of the sample. The method can be used for quantitative, non-invasive, in-vivo detection of glucose in living subjects and other active metabolic systems.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G01N 21/3586 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation by Terahertz time domain spectroscopy [THz-TDS]
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/0507 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves using microwaves or terahertz waves
G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
53.
METHODS AND CELLS FOR REMOVING LACTATE FROM ACID WHEY
The present invention relates to methods and bacterial cells for removing lactate from acid whey (AW) containing lactate. In particular, provided are de-acidified AW products and dried whey powders, for example spray-dried whey powders, obtained by the methods or bacterial cells disclosed herein.
A23J 1/20 - Obtaining protein compositions for foodstuffsBulk opening of eggs and separation of yolks from whites from milk, e.g. caseinObtaining protein compositions for foodstuffsBulk opening of eggs and separation of yolks from whites from whey
54.
AN IMPROVED SERS SUBSTRATE WITH A LAYER COMPRISING HALIDE
A surface-enhanced Raman spectroscopy (SERS) substrate and methods for manufacturing SERS substrates is described. The SERS substrate comprises a gold surface portion on which a layer comprising a halide is provided. Described is a method for performing SERS for detection or sensing of an analyte, wherein the method comprises manufacturing a SERS substrate. Described is also a SERS substrate manufacturing kit suitable for manufacturing said SERS substrate and/or for performing SERS analyte detection and further the use of the provided SERS substrate(s) in a method for drug sensing.
An angled fiber-based neural implant for neuromodulation and a method to manufacture such a neural implant is presented. The angled fiber-based neural implant comprises a fiber shank for inserting in neural tissue. The fiber shank comprises an optical waveguide, and the optical waveguide comprises a core and a cladding adapted so that light is able to propagate along the length of the optical waveguide. The shape of the core is arranged for providing a substantially uniform intensity distribution of light radiation from the core at the fiber tip, and the fiber tip comprises an angled surface. The end of the core and the end of the plurality of conduits are exposed at the angled surface, so that the plurality of conduits emanates at two, or more, different levels, where each level comprises a different depth into the tissue.
The present invention relates to a Synthetic Cellular Advanced Signal Adapter (SCASA) system and method comprising a genetically modified yeast cell capable of modulating a receiver cell, preferably a human immune cell. The invention provides systems to dynamically modulate the phenotype of the receiver cell in response to dynamic stimulation of the genetically modified yeast cell.
The present invention relates to microbial cell factories, in particular yeast cell factories, for production of modified betalains, such as acylated and di-glycosylated betalains.
The invention relates to a modified mammalian dimeric receptor protein having enhanced protein stability in solution. The two polypeptide chains of the modified dimeric receptor are expressed as fusion proteins, whereby one polypeptide chain is covalently fused to a peptide comprising a single chain nanobody, while the second polypeptide chain is covalently fused to a peptide comprising an antigenic peptide cognate for the nanobody. The invention further relates to methods of screening ligands for the modified dimeric receptor, and methods for introducing and presenting antigenic ligands in said receptors. The invention further relates to the use of a nanobody and an antigenic peptide cognate to said nanobody to stabilise or enhance selective pairing of the polypeptides of a dimeric fusion protein.
The present invention relates to the finding of the role of DCAF15 in protein aggregation. The present invention further relates to PROTACs and HyT-PD molecules for targeted protein degradation (TPD) of DCAF15 as well as their use as a medicament for the treatment of amyloidosis, in particular their use in the treatment of synucleinopathies.
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07D 241/04 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
C07D 241/44 - Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
C07D 277/22 - Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
A fermentation enhancement device for use in a bioreactor, the fermentation enhancement device comprising: an electrical charge structure defining an inner volume arranged for accommodating a fermentation process, the electrical charge structure comprising: a piezoelectric proliferation layer exposed to the inner volume; and a piezoelectric virucidal layer arranged at an outer surface of the electrical charge structure; an opening configured to allow therethrough a flow of nutrients and/or bacteria; wherein the fermentation enhancement device is arranged such that actuation of the electrical charge structure, by an actuation source, generates an electrical charge at the virucidal layer that kills and/or inactivates viruses, and an electrical charge at the proliferation layer that stimulates bacterial growth.
ZINC-CONTAINING PARTICLES, METHOD OF MANUFACTURING SUCH PARTICLES BY A THERMAL EVAPORATION-CONDENSATION PROCESS, AND COATING COMPOSITION COMPRISING SUCH PARTICLES
The invention relates to zinc-containing particles and a method of manufacturing such zinc-containing particles by a thermal evaporation-condensation process performed in a heated chamber (2). A zinc-containing source material (9) is supplied to the heated chamber. The heated chamber comprises an evaporation section where the zinc-containing source material is fully or partly vaporized to the gas phase, and a condensation section where zinc vapour is nucleated and/or condensed heterogeneously, and may be collected on a surface, such as a particle collector (11), in a cyclone or a filter. The zinc-containing particles have special shapes and properties compared to prior art zinc-containing particles. The invention further relates to a coating composition comprising such zinc-containing particles.
B22F 9/12 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using physical processes starting from gaseous material
C22C 1/04 - Making non-ferrous alloys by powder metallurgy
B22F 1/06 - Metallic powder characterised by the shape of the particles
The invention relates to securing a sufficient supply of blood having substantially reduced levels of A antigens, and the extended Gal-A, H type 3, A type 3 antigens as well as B antigens and the extended GalNAc-B antigens that can be used to supplement supplies of donor-derived blood group O red blood cells. The invention provides enzyme-converted red blood cells, and enzyme cocktails for converting extended A-type and/or -B-type antigens, in addition to A-, and B-antigens on the surface of donor red blood cells.
C12N 9/40 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood groups or blood types
A major challenge in the field of antibody-based therapeutics is the development of antibodies with enhanced duration of action, prolonged half-life and which can be delivered at lower dose to patients. Current approaches to achieve this rely on engineering of pH-dependent antigen binding properties to antibodies which are laborious, and typically require further optimization of pH-sensitive interactions in a low- throughput, case-to-case manner as they largely rely on introduction of histidines mutations to the specific antibody complementarity-determining regions (CDRs). In the present invention, the inventors provide antibodies and other antigen-binding proteins carrying mutations outside of the paratope conferring universal pH sensitive binding properties to antibodies. The invention also relates to methods of isolating and generating said antigen-binding proteins, compositions and medical uses thereof.
The invention relates to a high-speed atomic force microscope (AFM, 1) for measurement of an associated sample (S), such as a skin sample, the AFM has a sensor unit (SU, 10) with a light source (11) and a collimator lens (12), the collimating lens is mechanically displaceable with a collimator lens actuator (12'). An AFM cantilever with an AFM tip (14) is arranged relative to photo detection beams (15) for providing a focus error signal (FES) indicative of mechanical engagement with the sample. The collimator lens (12) is arranged for being adjusted by the collimator lens actuator (12') along the optical beam path so as to compensate at least for thermal drift in the focus error signal (FES). The invention is advantageous for obtaining an improved high-speed AFM by this internal thermal drift compensation mechanism. The high-speed AFM of one embodiment of the invention may have a theoretical linear scanning speed that can reach 700,000 μm/s, which allows one imaging to be completed in around 3.4 seconds.
The present disclosure relates to a micropump comprising: a fluid section comprising: a pumping cavity; an inlet; an outlet; a diaphragm; and an actuator section comprising: a coil; a plurality of magnets arranged at an end of the coil; an armature at least partly arranged in the coil, extending into a space between the plurality of magnets, further protruding from the space between the plurality of magnets, wherein the armature is configured to deflect between the plurality of magnets when an alternating magnetic field is generated by the coil; at least one drive rod attached to the armature and to the diaphragm, wherein the micropump is configured to draw a fluid into the fluid section via the inlet and discharge the fluid via the outlet when the drive rod causes the diaphragm to oscillate. The disclosure further relates to a method for pumping a fluid.
The present disclosure relates to a method for producing a three-dimensional object comprising: computing a plurality of subsinograms, wherein the subsinograms are derived from at least one sinogram describing the three-dimensional object to be formed from different orientation angles; providing a build volume comprising a photosensitive component capable of initiating a photochemical reaction upon irradiation by light of an activation wavelength; irradiating the build volume, by each of a plurality of projection units, with a projection of a series of patterns of light corresponding to one of the subsinograms, at the corresponding orientation angles, wherein the irradiating light comprises the activation wavelength, and wherein each projection unit irradiates the build volume with a series of patterns of light that is derived from a different subsinogram, such that the build volume is irradiated by a resulting series of patterns of light corresponding to the sinogram at the corresponding orientation angles.
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B29C 64/282 - Arrangements for irradiation using multiple radiation means, e.g. micromirrors or multiple light-emitting diodes [LED] of the same type, e.g. using different energy levels
B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
FUNDACIÓN AGENCIA ARAGONESA PARA LA INVESTIGACIÓN Y EL DESARROLLO (ARAID) (Spain)
Inventor
Blixt, Ola
Guerrero, Ramón Hurtado
Gatos, Spyridon
Abstract
The invention provides specific antibodies, antibody libraries and methods for identifying specific antibodies, which target Tn- and/or STn- glycosylation sites of any glycoprotein of choice, especially glycoproteins of cancer cell targets. The antibodies identified by the new concept proposed herein have combined specificity towards both the sugar epitope as well as the peptide epitope of the glycoprotein of the cancer cell.
C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
69.
TEST HOUSING FOR SPECTROSCOPIC INVESTIGATION OF A WORKING ELECTRODE TRODE
The disclosure regards a test house for a working electrode, comprising: at least one gas chamber comprising at least one gas inlet and one gas outlet defining a gas flow direction in the gas chamber, at least one electrolyte chamber comprising at least one electrolyte inlet and one electrolyte outlet defining an electrolyte flow direction in the electrolyte chamber, and at least one separator defining an interface between the gas chamber and the electrolyte chamber, said separator configured for supporting a superjacent working electrode, and further configured to be permeable to the electrolyte flow such that an electrolyte flow is supplied to the superjacent working electrode, wherein the separator is non-porous or at least partly non-porous, and optionally multi-layered, or porous or at least partly porous, and multi-layered.
FUNDACIÓN AGENCIA ARAGONESA PARA LA INVESTIGACIÓN Y EL DESARROLLO (ARAID) (Spain)
Inventor
Blixt, Ola
Hurtado Guerrero, Ramón
Gatos, Spyridon
Abstract
The invention provides specifc Tn- and STn antibody libraries and methods for identifying specifc antibodies, which target Tn- and/or STn- glycosylation sites of any glycoprotein of choice, especially glycoproteins of cancer cell targets. The invention further provides antibodies identified by the new concept prosposed herein, which have combined specificity towards both the carbohydrate epitope as well as the peptide epitope of the glycoprotein.
C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
The present disclosure relates to a solid-state polycrystal with elevated ionic conductivity that provides an electrolyte for solid-state batteries including particular potassium ion batteries. The solid-state polycrystal is stable to atmospheric air and its manufacture follows a cheap and scalable process.
H01B 1/06 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances
H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances
H01M 8/1016 - Fuel cells with solid electrolytes characterised by the electrolyte material
72.
A METHOD FOR PREPARING MICROPARTICLES FOR DRUG DELIVERY
Disclosed is a method for preparing microparticles for drug delivery. The method comprises providing a mold comprising multiple individual, open compartments arranged on a first surface of the mold. The open compartments are separated from each other by one or more edges. Each edge has a width of 5 µm or less. The method comprises coating the first surface of the mold with a mold layer comprising a biocompatible and/or biodegradable material having a first release characteristic at a first condition. The method comprises loading the compartments coated with the mold layer with a pharmaceutical composition comprising a drug substance. The method comprises coating the first surface of the mold with a top layer comprising a biocompatible and/or biodegradable material having a second release characteristic at the first condition for provision of closed microparticles in the multiple individual compartments. The method comprises separating the closed microparticles by cutting the mold layer and the top layer using the one or more edges. By cutting the mold layer and the top layer using the one or more edges discrete microparticles are provided.
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
73.
MONODISPERSE NANOFIBROUS MICROPARTICLES FOR DELIVERY OF ONE OR MORE ACTIVE SUBSTANCES
Disclosed herein are a new type of advanced microparticles for delivery of an active substance. The microparticles exhibit a complex and porous bulk morphology composed of one or more layers of electrospun nanofibrous materials and/or compounds.
D01D 5/00 - Formation of filaments, threads, or the like
A61K 31/00 - Medicinal preparations containing organic active ingredients
A61K 31/43 - Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
A61K 33/00 - Medicinal preparations containing inorganic active ingredients
A61J 3/00 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
The invention relates to an optical system (1) comprising a nanocavity (2)having at least one nanostructure (3) shaped to provide sub-wavelength confinement of an electromagnetic optical field. The nanocavity (2) is shaped and formed to host a bound state in the continuum to provide spatial concentration and temporal storage of the electromagnetic optical field at the at least one nanostructure via an eigenmode of the electromagnetic optical field in the nanocavity. The invention further relates to a method for processing an electromagnetic optical field.
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
G02B 6/136 - Integrated optical circuits characterised by the manufacturing method by etching
75.
SYSTEM AND METHOD FOR HIGH PRECISION DIGITAL OPTICAL PROCESSING
The invention regards a digital optical computing processing unit configured to perform analogue-digital convolutions by processing at least a first and a second electrical digital signal, a digital optical computing processing unit configured to perform analogue-digital continuous convolutions by processing at least a first, a second and a third electrical digital signal and a digital optical computing processing unit configured to perform digital-digital multiplications by processing at least a first, a second and a third electrical digital signal. Methods for hybrid optical-electrical convolution between matrixes and a method for a hybrid optical-electrical multiplication of a first digital signal with a second digital signal are also disclosed.
G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference
G02F 1/225 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference in an optical waveguide structure
76.
AN OPTICAL METASURFACE AND A METHOD FOR PRODUCING AN OPTICAL METASURFACE
The invention relates to an optical metasurface to interact with incoming light and a method for producing an optical metasurface. The optical metasurface may be used as a meta-lens, a blazed grating, a phase plate or another optical device. The optical metasurface is comprising a transparent substrate comprising a plurality of nano-holes or nano-pillars. The plurality of the nano-holes or nano- pillars of the transparent substrate are covered by a plurality of shaped layers comprising a transparent dielectric material.
The present disclosure relates to a copolymer-drug-conjugate. Specifically disclosed herein are copolymer-drug-conjugates having good tissue retention. Disclosed herein are also copolymer-drug-conjugates for use in medicine, such as for use in the treatment of cancers. Disclosed herein are also methods for producing such copolymer-drug-conjugates.
A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
Provided herein are composition including lipids and copolymers in the form of a nanodisc assembly. The copolymers include monomer units of methacrylic acid and styrene. Also provided herein is an aqueous solution comprising the subject composition, methods of producing the nanodisc assembly. Further provided are methods of solubilising hydrophobic constituents such as membrane proteins in aqueous solution, including forming nanodisc assemblies of a lipid, the hydrophobic constituent, and the subject copolymer.
A method for producing self-assembled polymersomes in a aqueous solution, wherein said polymersomes comprise amphiphilic diblock copolymers of the P1-b-P2 type, said method comprising the step of synthesizing R-C-O-P1-b-P2 block copolymers comprising a silyl ether (-C-O-Si-) bond and wherein P1 is a hydrophobic polymer and P2 is a hydrophilic polymer and R is any atom or group of atoms, wherein said synthesis comprises ring-opening polymerization of a cyclic monomer by an initiator in the presence of a catalyst, the initiator comprising a carbon-bound hydroxyl.
C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
A polymersome comprising an amphiphilic triblock copolymer of the poly(ethylene glycol)-b-poly(caprolactone)-b- poly(ethylene glycol) (PEG-b-PCL-b-PEG) type.
C08G 63/664 - Polyesters containing oxygen in the form of ether groups derived from hydroxycarboxylic acids
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
C08G 63/685 - Polyesters containing atoms other than carbon, hydrogen, and oxygen containing nitrogen
C08G 63/91 - Polymers modified by chemical after-treatment
C08G 65/332 - Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides or esters thereof
The invention relates to a modular scale-down reactor comprising two or more reversibly attached reactor units, one or more inlet apertures, one or more outlet apertures, and at least one disk to be inserted between two adjacent reactor units or within an inner reaction unit. The invention further relates to the use of said scale-down reactor for simulating, modelling, monitoring or modifying the conditions in a large-scale reactor.
C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
C12M 1/00 - Apparatus for enzymology or microbiology
82.
A METHOD OF USING OPTICAL COHERENCE TOMOGRAPHY FOR TRAINING A MACHINE LEARNING MODEL, A METHOD OF DETERMINING AN UNKNOWN CONDITION USING THE TRAINED MODEL, A METHOD OF DETERMINING SEGMENTATION IN A SAMPLE, AND AN OPTICAL COHERENCE TOMOGRAPHY SYSTEM
The disclosure regards a method of using optical coherence tomography for training a machine learning model, the method comprising the steps of illuminating a first sample having a known condition along an illumination path, capturing a first training image of the sample along a first training collection path, wherein the first training collection path is spatially and/or angularly offset from the illumination path by a first training offset, capturing a second training image of the sample along a second training collection path different from the first training collection path for providing a reference image, and training a machine learning model based on the first and second training images and the known condition.
One aspect of the present disclosure relates to a system for detecting aerial vehicles, the system comprising a continuous-wave coherent lidar unit selectively operable in at least a detection mode and an imaging mode. The continuous-wave coherent lidar unit is configured, when operated in the detection mode: to emit and/or scan a continuous-wave laser detection beam towards a detection target region, and to receive a return laser signal from the detection target region by coherent detection. The system is configured to process the return laser signal, received by the continuous-wave coherent lidar unit when operated in the detection mode, so as to detect one or more signal features indicative of the presence of an aerial vehicle in the detection target region, and to determine one or more attributes of the said aerial vehicle in the detection target region from the detected one or more signal features. The continuous‐wave coherent lidar unit is further configured, when operated in the imaging mode to scan a focused continuous‐wave imaging laser beam across an imaging target region, and to receive respective return laser signals from respective positions within the imaging target region by coherent detection. The system is configured to process the return laser signals, received from respective positions by the continuous‐wave coherent lidar unit when operated in the detection mode, to create at least one two‐dimensional image of the imaging target region.
G01S 7/48 - Details of systems according to groups , , of systems according to group
B64U 101/00 - UAVs specially adapted for particular uses or applications
F41H 11/02 - Anti-aircraft or anti-guided missile defence installations or systems
G01S 7/481 - Constructional features, e.g. arrangements of optical elements
G01S 17/04 - Systems determining the presence of a target
G01S 17/34 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated using transmission of continuous, frequency-modulated waves while heterodyning the received signal, or a signal derived therefrom, with a locally-generated signal related to the contemporaneously transmitted signal
G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
The present invention relates to a method for manufacturing of free-standing carbon electrodes comprising a patterned three-dimensional structure which was filled with a biomass-derived polymer. 5
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
There is presented a computer-implemented method for modal analysis in the frequency domain of a physical structure, said computer-implemented method comprising obtaining free decay vibration response data expressed in the frequency domain for the structure, formulating frequency domain equations based on the free decay vibration response data and comparing two or more points in the frequency domain, formulating a single or multiple order eigenvalue problem based on the formulated frequency domain equations, and solving the single or multiple order eigenvalue problem thereby obtaining one or more modal parameters.
The present invention relates to the field of biomass waste feedstock conversion into value-added chemicals. Specifically, the present invention relates to a method production of a chemical derived from biomass or derived from a biomass-derived material using homogenous catalysis.
C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
C07C 29/149 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof with hydrogen or hydrogen-containing gases
The present invention relates to a solid oxide cell, such as a solid oxide fuel cell (SOFC) or a solid oxide electrolyser cell (SOEC), containing at least one structural component comprising doped zirconia, which includes more than 80 Vol% of metastable transformable tetragonal zirconia ceramic materials, having a superior resistance to high-temperature isothermal degradation.
H01M 8/1007 - Fuel cells with solid electrolytes with both reactants being gaseous or vaporised
H01M 8/22 - Fuel cells in which the fuel is based on materials comprising carbon or oxygen or hydrogen and other elementsFuel cells in which the fuel is based on materials comprising only elements other than carbon, oxygen or hydrogen
H01M 8/1253 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte the electrolyte consisting of oxides the electrolyte containing zirconium oxide
H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells
89.
BIOCONTAINMENT STRATEGIES FOR IN VIVO APPLICATIONS OF YEASTS
The invention relates to a genetically engineered cell and compositions comprising said cell, wherein said cell is engineered to be especially sensitive towards two or more environmental factors, to enhance the biosafety profile of said cell.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
90.
SYSTEM AND METHODS FOR TOMOGRAPHIC VAT PHOTOPOLYMERIZATION
The invention regards an a method of fabricating a three-dimensional object by tomographic vat photopolymerization comprising computing a number of primary projections describing the three-dimensional object; and wherein the primary projections comprise positive and negative intensity values; deriving, from each primary projection, a positive and a negative projection, corresponding to the positive and negative intensity values respectively; providing a build volume (24) comprising: a monomer; a precursor of a stable radical scavenger inducible by light of a first wavelength and wherein said stable radical scavenger is sensitive to light of a second wavelength; and a photosensitive component capable of initiating polymerization of the monomer by light of the second wavelength; and irradiating the build volume at the respective corresponding orientations with light of the first wavelength in a first series of patterns of light; and light of the second wavelength in a second series of patterns of light.
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
The invention regards a cell culture insert comprising a chamber defined by at least one side wall and a first end wall, wherein the first end wall has a thickness equal to or below 500 µm and comprises at least one opening, wherein the at least one opening is defined by an opening perimeter, the perimeter having a surface configured for supporting a suspended membrane at the edges of the membrane by surface tension.
Methods involving high temperature solution treatment that improve corrosion and wear resistance and strength of Ni-free high-Mn austenitic stainless steels are disclosed, together with Ni-free high- Mn austenitic stainless steels, articles and components so treated.
The present invention concerns the use of light to convert indicant to indigo. The invention is particularly useful in dyeing textiles from indican by simple light exposure, thereby providing a greener alternative to current industrial processes for colored fabrics and other products.
C09B 67/30 - Preparations of vat or sulfur dyes in liquid form
D06P 1/22 - General processes of dyeing or printing textiles or general processes of dyeing leather, furs or solid macromolecular substances in any form, classified according to the dyes, pigments or auxiliary substances employed using vat dyestuffs
D06P 3/00 - Special processes of dyeing or printing textiles or dyeing leather, furs or solid macromolecular substances in any form, classified according to the material treated
94.
METHOD FOR FABRICATING SIC-ON-INSULATOR MATERIAL STACKS
The invention regards a method for nanofabricating a SiC-on-insulator material stack, comprising the steps of providing a SiC layer comprising a first proximal surface and a first distal surface, providing a Si substrate comprising a SiOx layer on a second proximal surface, depositing a first adhesive layer and a second adhesive layer of an adhesive material on the first and the second proximal surfaces, respectively, contacting the first adhesive layer and the second adhesive layer with each other, and curing the first and the second adhesive layers for forming a SiC on-insulator material stack.
The invention regards a flow cell for electrochemical ammonia synthesis, comprising a cathode, an anode, and an electrolyte chamber, wherein the anode comprises a HOR catalyst comprising bimetallic Pt, and/or wherein the electrolyte chamber comprises one or more spacers having a height defining a distance between the anode and cathode.
C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
C25B 11/081 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the element being a noble metal
C25B 11/097 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds comprising two or more noble metals or noble metal alloys
The disclosure relates to a synthetic method of producing delta-cyclodextrin. The method is scalable, and the isolation of the product does not require chromatography.
The present disclosure relates to a system and a method of performing Gaussian boson sampling via time multiplexing correlation of squeezed vacuum states for quantum information experiments. One embodiment relates to a method for performing Gaussian boson sampling comprising the steps of - generating a set of pulsed pairs of squeezed vacuum states, - performing time multiplexed correlation of multiple of such pairs of squeezed vacuum states, - measuring, via a homodyne detection, a state from the pairs of generated squeezed vacuum states, - feed-forwarding the homodyne result of the measured states to a displacement unit, - performing displacement operations on the remaining state from the pairs of generated squeezed vacuum states, and - counting the states output from the displacement unit.
A method for preparing an adhesive, said method comprising - mixing chitosan and tannic acid in an aqueous solution, and adjusting the pH value of the resulting mixture to a pH that induces the formation of a polymer-rich phase and a polymer-poor phase, preferably in a pH range of from 4.5 to 6, such as from 5 to 5.5 to obtain a polymer-rich phase and a polymer-poor phase; and - isolating the polymer-rich phase to obtain said adhesive. Described is also an adhesive obtainable from said method and uses thereof.
The invention relates to an implant system for a patient, comprising an implant body adapted to be implanted in or on a body part of the patient, a disinfection portion comprising one or more depressions formed on an exterior surface of the disinfection portion, a plurality of light units, wherein each light unit comprises a light emitter and an electromagnetic coil arranged to power the light emitter when the electromagnetic coil is exposed to a magnetic flux and wherein the plurality of light units are at least partly contained within the one or more depressions.
The invention relates to a cannula for a dental irrigation system comprising a body extending in an axial direction between a proximal end and a distal end, and comprising at least two separate conduits extending in the axial direction between at least one proximal opening and at least two distal openings. Each of the at least two separate conduits terminate at a separate opening of the at least two distal openings. The invention further relates to a cannula comprising a body with a non-circular cross section, to a dental irrigation system, to a method of irrigating a root canal, to a method of manufacturing a cannula, and to a dental irrigation system for use in endodontic therapy.
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