The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61M 5/165 - Filtering accessories, e.g. blood filters, filters for infusion liquids
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 39/20 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
2.
The Use of a Hemocompatible Porous Polymer Bread Sorbent for Removal of Pamps and Damps
The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
C08F 299/00 - Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
C08J 9/26 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
4.
Crosslinked polysaccharide based absorbents for removal of anti-A and/or anti-B antibodies from human plasma and whole blood
The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
C07K 16/06 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies from serum
5.
Process for functionalizing a biocompatible polymeric bead, the functionalized beads, and the beads produced thereby
The invention involves functionalizing polymeric beads, such as DVB beads, to add an epoxide or aldehyde group. The resulting beads are useful in various applications.
The invention involves functionalizing polymeric beads, such as DVB beads, to add an epoxide or aldehyde group. The resulting beads are useful In various applications.
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical apparatus and instruments; medical devices, namely, absorption devices and polymeric absorption materials for removing materials from blood or blood fractions. Educational services, namely, conducting training, workshops and conferences in the field of devices, instruments and techniques for hemoperfusion procedures, and in using kits comprising such devices, instruments and instructions for practicing the techniques, and in using the parts and accessories for all of the foregoing medical devices, instruments and techniques. Medical consultation services, namely, medical consultation in the field of devices, instruments and techniques for hemoperfusion procedures, and the field of kits comprising such devices, instruments and instructions for practicing the techniques, as well as consultation regarding the parts and accessories for all of the foregoing medical devices, instruments and techniques; medical consultation services, namely, medical consultation services for physicians and medical researchers in the field of medical devices, instruments and techniques for hemoperfusion procedures, and the field of kits comprising such devices, instruments and instructions for practicing the techniques, including consultation with physicians and medical researchers regarding such medical devices, instruments, and techniques; and providing online medical information for physicians and patients regarding such medical devices, instruments and techniques.
A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one polymer with a plurality of pores, and the polymer has at least one transport pore with a diameter from about 250 Angstroms to about 2000 Angstroms, and the polymer has a transport pore volume greater than about 1.8% to about 78% of a capacity pore of volume of the polymer.
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical apparatus and instruments; medical devices, namely, absorption devices and polymeric absorption materials for removing materials from blood or blood fractions. Educational services; educational services, namely, conducting training, workshops and conferences in the field of devices, instruments and techniques for hemoperfusion procedures, and in using kits comprising such devices, instruments and instructions for practicing the techniques, and in using the parts and accessories for all of the foregoing medical devices, instruments and techniques. Medical consultation services, namely, medical consultation in the field of devices, instruments and techniques for hemoperfusion procedures, and the field of kits comprising such devices, instruments and instructions for practicing the techniques, as well as consultation regarding the parts and accessories for all of the foregoing medical devices, instruments and techniques; medical consultation services, namely, medical consultation services for physicians and medical researchers in the field of medical devices, instruments and techniques for hemoperfusion procedures, and the field of kits comprising such devices, instruments and instructions for practicing the techniques, including consultation with physicians and medical researchers regarding such medical devices, instruments, and techniques; and providing online medical information for physicians and patients regarding such medical devices, instruments and techniques.
10.
REMOVAL OF MYOGLOBIN FROM BLOOD AND/OR PHYSIOLOGICAL FLUIDS
A polymer sorbent clears myoglobin from blood and/or other physiological fluids and solutions. Normal saline or human serum in which myoglobin was dissolved is perfused by a peristaltic pump through a column packed with the polymer sorbent. After a four-hour perfusion, the myoglobin level in normal saline fell from initial levels to virtually undetectable levels. Perfusion through the polymer sorbent was then found to lower concentrations of dissolved myoglobin to a significant degree in samples of human serum after four hours, indicating that the polymer sorbent is an effective sorbent for myoglobin.
