Abstract

The present invention refers to a biomaterial film comprising a protein component, in a concentration comprised between 2 and 8 % by weight, monosaccharides/disaccharides, in a concentration comprised between 0.5 and 2 % by weight, agar, in a concentration comprised between 0.1 and 1 % by weight, and glycerol, in a concentration comprised between 0.2 and 1.5 % by weight, wherein the film has a thickness comprised between 70-150 μm and a rugosity lower than 70 GU. The invention also refers to a method for preparing said biomaterial film. The use of the biomaterial film in medicine, in particular, in the treatment of chronic tympanic membrane perforation is also contemplated. Finally, the present invention refers to an implant comprising the biomaterial film of the invention.

IPC Classes  ?

• A61F 11/00 - Methods or devices for treatment of the ears or hearing sense Non-electric hearing aidsMethods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing senseProtective devices for the ears, carried on the body or in the hand
• A61L 27/20 - Polysaccharides
• A61L 27/22 - Polypeptides or derivatives thereof

Abstract

HH-imidazo[4,5-c]quinoline metal-based complexes which coordinate an imiquimod-derived ligand and another one or more which can be monodentate, polydentate, and haptic, pharmaceutical compositions comprising them, as well as such metal complexes for use as a medicament, in particular for use in the treatment of viral infection, or in the treatment of cancer.

IPC Classes  ?

• C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
• A61K 31/7135 - Compounds containing heavy metals
• A61P 31/12 - Antivirals
• A61P 35/00 - Antineoplastic agents
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Abstract

The present invention relates to a method for preparing an organic-inorganic hybrid solid electrolyte (HSE) based on an inorganic phase synthesized in-situ in the presence of polymer. The approach described delivers flexible membranes with high ionic conductivity values (>10-4S/cm at room temperature) and excellent mechanical properties, especially in terms of yield stress (σy), which are suitable for electrochemical applications in solid-state lithium metal batteries.

IPC Classes  ?

• H01M 10/0562 - Solid materials
• H01M 10/052 - Li-accumulators
• H01M 10/056 - Accumulators with non-aqueous electrolyte characterised by the materials used as electrolytes, e.g. mixed inorganic/organic electrolytes

Abstract

The invention generally relates to microfluidic devices and uses thereof. In particular, the present invention relates to a microfluidic device and its use for analyzing or collecting root exudates and/or root microbiome exudates both within different regions of the root as well as at different moments.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The invention relates to a joining device (1) for wooden structures comprising two elongated parts (2,3) which can be coupled to and uncoupled from one another in an axial direction. Each part has: a cylindrical intermediate stem (2a, 3a), a head (2b, 3b) at one end of the cylindrical intermediate stem, a rod (2c, 3c) emerging from the other end of the cylindrical intermediate stem, with the cross- section in the entirety of the rod having a smaller surface than the cross-section of the cylindrical intermediate stem. The two parts are configured such that, when axially coupled, they can adopt two angular positions relative to one another, a locking position in which widenings (2d, 3d) of the rods are superimposed such that the two parts are axially anchored to one another, and a release position in which the relative axial movement between both parts in opposite directions is allowed. The device of the invention reduces the dimension of the perforation made on the elements, i.e., boards or bars, to be joined, thereby preventing the weakening of the joint.

IPC Classes  ?

• F16B 21/02 - Releasable fastening devices locking by rotation

Abstract

It relates to aldoximes or pharmaceutically acceptable salts thereof or isomers thereof able of releasing nitric oxide (NO) for use in the treatment of a condition or a disease which is sensible to the action of the NO, wherein the treatment comprises administering the aldoxime to a subject and releasing NO from the aldoxime through an in vivo enzymatically catalyzed redox reaction at physiological pH, as well as to the in vivo use of such aldoximes or acceptable salts for plants thereof or isomers thereof for biological applications which are sensible to the action of the NO in plants, wherein the biological application is selected from the group consisting of plant rooting agent, plant structure modifier, stimulators of the tolerance to abiotic or biotic stress, plant protector from stress induced by ammonium nutrition as an exclusive source of nitrogen, plants protector from hydric stress, and as germination inducer. It also relates to compositions comprising them.

IPC Classes  ?

• A61K 31/15 - Oximes (C=N—O—)Hydrazines (N—N)Hydrazones (N—N=)
• A61G 13/00 - Operating tablesAuxiliary appliances therefor
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• A61P 35/00 - Antineoplastic agents
• C07C 251/32 - Oximes

Abstract

In one aspect, a flow cell (100) for liquid-phase transmission electron microscopy comprising an imaging portion (140) and a surrounding portion (150) in fluid communication with the imaging portion is provided. A height (153) of the channel (130) in the surrounding portion is configured to be greater than a height (143) of the channel in the imaging portion; and a length (164, 174) of the imaging portion is selected to achieve mass transport of the one or more fluids preponderantly by diffusion in the imaging portion. In a further aspect, a method of manufacturing the flow cell is provided.

IPC Classes  ?

• H01J 37/20 - Means for supporting or positioning the object or the materialMeans for adjusting diaphragms or lenses associated with the support

Abstract

The invention relates to a method and a device for measuring the adsorption of adsorbent materials of chemical substances dissolved in a liquid medium. The method comprises a container containing a liquid medium with magnetically particles of an adsorbent material, and a substance dissolved in the liquid medium, and placing the container in proximity to at least one permanent magnet. The separation distance between the permanent magnet and the container is increased, until the magnetic attraction of the permanent magnet no longer holds the magnetically active particles. The method comprises measuring the separation distance between the permanent magnet and the container at which all or a predetermined amount of the magnetically active particles have fallen by gravity to the bottom of the container, and determining, by linear correlation, the mass of substance captured by the magnetically active particles based on the measured separation distance.

IPC Classes  ?

• G01N 15/04 - Investigating sedimentation of particle suspensions

Abstract

The present invention is comprised within the fields of molecular biology and biotechnology. It specifically relates to polypeptides for the generation of Backpacked-antibody (B-ab) molecules for a variety of uses, in particular, for the specific delivery of drugs to tumor cells.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 9/51 - Nanocapsules
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/775 - Apolipopeptides
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

The invention relates to a method for producing a plasma enriched with platelets and plasma biomolecules, and to the produced plasma itself. The method of the invention comprises centrifuging, evaporating and adjusting the pH of a blood sample.

IPC Classes  ?

• A61K 35/16 - Blood plasmaBlood serum
• A61K 35/19 - PlateletsMegacaryocytes

Abstract

The present invention relates to a method for converting mechanical energy from oscillations into electrical energy, the method comprising adjusting a displacement of a mass (1) mechanically coupled to an electrical machine (3), the coupling being such that the electrical machine (3) generates the electrical energy from the displacement of the mass (1) in the oscillations, the displacement being with respect to an oscillating body; the displacement being adjusted by means of an adjustment of a force applied by the electrical machine (3) to the mass (1); and the applied force being adjusted by means of a controller configured so that a control objective is to achieve that an instantaneous velocity of the displacement of the mass (1) is positively accelerated by a gravitational force (Fg) applied to the mass (1) at certain instants of the oscillations.

IPC Classes  ?

• F03B 13/14 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy
• F03B 13/20 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy using the relative movement between a wave-operated member and another member wherein both members are movable relative to the sea bed or shore
• F03B 15/00 - Controlling

Abstract

The present invention relates to a wave energy to electrical energy converter, the wave energy converter comprising a hull (1), a movable mass (3), a guide (4) for displacement of the mass (3) and an electric power generator (10); the electric power generator (10) comprising a rotor, the mass (3) being coupled to the rotor by means of a mechanism configured to convert displacement of the mass (3) into rotation of the rotor; the mass (3), the guide (4), the generator (10) and the mechanism being in the hull (1); the guide having a port to starboard direction; the converter comprising a controller configured to adjust a rotor torque on the basis of the instantaneous position of the mass (3), instantaneous velocity of the mass (3) and the rolling of the hull (1).

IPC Classes  ?

• F03B 13/20 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy using the relative movement between a wave-operated member and another member wherein both members are movable relative to the sea bed or shore
• F03B 15/00 - Controlling
• F03G 7/08 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for recovering energy derived from swinging, rolling, pitching, or like movements, e.g. from the vibrations of a machine

Abstract

The present invention relates to a composition useful for the formation of polycarbonate foams with no need of external blowing agent. The invention also relates to a process for the preparation of a polycarbonate foam, to a polycarbonate foam resulting from said process and to a kit of parts for the preparation of a polycarbonate foam.

IPC Classes  ?

• C08G 63/64 - Polyesters containing both carboxylic ester groups and carbonate groups
• C08G 64/18 - Block or graft polymers
• C08G 64/30 - General preparatory processes using carbonates
• C08J 9/02 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof using blowing gases generated by the reacting monomers or modifying agents during the preparation or modification of macromolecules
• C08G 64/02 - Aliphatic polycarbonates

Abstract

The inventors of the present invention have developed a support that couples the controlled seeding of cells into predetermined patterns with the presentation and/or detection of molecules of interest to/from said cells. Said support is characterized for containing predetermined patterns where cells adhere to and have a uniform layer of gel functionalized with a molecule of interest or an uniform layer of gel and microbeads functionalized with a molecule of interest.

IPC Classes  ?

• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

Abstract

The invention discloses a device (1) for diagnosing and rehabilitating balance that comprises a platform (2) supported by a kinematic mechanism (3). The kinematic mechanism (3) comprises four kinematic chains (31, 32, 33, 34). The first, second and third kinematic chains (31, 32, 33) are the same, each of them comprising a proximal rod (BP31, BP32, BP33) attached by respective passive spherical pairs (PEI31, PEI32, PEI33) to a distal rod (BD31, BD32, BD33), and each being attached to a fixed base (B) by actuated proximal rotational pairs (PRPA31, PRPA32, PRPA33) and to the platform (2) by passive distal spherical pairs (PED31, PED32, PED33). The fourth kinematic chain (34) is attached to the fixed base (B) by an actuated proximal rotational pair (PRPA34) and to the platform (2) by a universal joint (JU34).

IPC Classes  ?

• A63B 22/18 - Exercising apparatus specially adapted for conditioning the cardio-vascular system, for training agility or co-ordination of movements with elements having a circulating or rotating movement, generated by oscillating movement of the user
• A63B 26/00 - Exercising apparatus not covered by groups
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61H 1/00 - Apparatus for passive exercisingVibrating apparatusChiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
• A61H 1/02 - Stretching or bending apparatus for exercising
• A63B 22/00 - Exercising apparatus specially adapted for conditioning the cardio-vascular system, for training agility or co-ordination of movements

Abstract

The invention refers to lipid nanoparticles in the form of nanostructured lipid carriers which comprise a matrix with at least a lipid which is solid at room temperature and at least a lipid which is liquid a room temperature, at least a surfactant and an antibody such as Adalimumab entrapped in the nanoparticle. The use of such nanoparticles for the treatment of an inherited retinal dystrophy, such as retinitis pigmentosa, allows the administration of antibodies against TNFα such as Adalimumab or biosimilars protected by nanoparticles which reach the posterior part of the eye, so that the nanoparticles of the present invention enable the use of the ocular topical route for the administration of the nanoparticles. Such administration reduces signs and symptoms of retinitis pigmentosa such as retinal inflammation and vision loss, ameliorating retinal function.

IPC Classes  ?

• A61K 9/10 - DispersionsEmulsions
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 9/51 - Nanocapsules
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Abstract

The present invention relates to a method for the preparation of a coating composition comprising an anti-infective agent for the controlled release of said anti-infective agent and to a coating composition or coated substrate obtainable by said method. Such coating compositions are particularly useful in the field of dentistry for the treatment or prevention of inflammatory processes such as mucositis or periimplantitis, preferably of periimplantitis.

IPC Classes  ?

• C09D 183/04 - Polysiloxanes
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention refers to a cell, to an energy storage or energy supply system comprising said cell, and to the use of the cell or the supply system to store or supply electricity.

IPC Classes  ?

• H01M 4/04 - Processes of manufacture in general
• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/052 - Li-accumulators
• H01M 10/44 - Methods for charging or discharging
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

The present invention is directed to new compounds based on polyelectrophilic metalated heterocycles derived from 2-(pyridin-2-yl)imidazo[1,2-a]pyridine, to their obtaining procedure, as well as to their use as chemotherapeutic agents, in particular against tumours sensitive or resistant to other chemotherapeutic agents, such as cisplatin.

IPC Classes  ?

• C07F 1/00 - Compounds containing elements of Groups 1 or 11 of the Periodic Table
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
• A61K 33/243 - PlatinumCompounds thereof
• A61P 35/00 - Antineoplastic agents
• C07D 471/04 - Ortho-condensed systems
• C07D 471/16 - Peri-condensed systems

Abstract

The present invention relates to the development of an electrochemical cell comprising a sulfur cathode comprising a combination of at least a carbonaceous material and a graphene-type material, said cathode being synergistically combined with Sparingly Solvating Electrolytes (SSEs). Additionally, the invention relates to a method for preparing said electrochemical cell and its use in Li-S secondary batteries.

IPC Classes  ?

• H01M 4/136 - Electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy
• H01M 4/1397 - Processes of manufacture of electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/0568 - Liquid materials characterised by the solutes
• H01M 10/0569 - Liquid materials characterised by the solvents

Abstract

The invention relates to a low-temperature organocatalyzed process for the depolymerization of materials comprising polyethylene terephthalate. The process comprises reacting a sample comprising poly(ethylene terephthalate) with a nucleophile in the presence of an aprotic solvent and a catalytic system comprising a N-containing organic base, and an alkaline or alkaline-earth metal organic or inorganic salt. The process affords monomeric terephthalate-based derivatives under mild conditions, namely the process does not require pre-treatment or prior purification of PET waste, it avoids energy-intensive steps and expensive equipment as it can be carried out in conventional reactors, at a temperature equal to or lower than 100 ºC, under ambient pressure and for short reaction times.

IPC Classes  ?

• C08J 11/24 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material by treatment with organic oxygen-containing compounds containing hydroxyl groups
• C08J 11/28 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material by treatment with organic compounds containing nitrogen, sulfur or phosphorus

Abstract

The present invention provides a device for the detection of compounds. Particularly, the present invention relates to a microfluidic device for the detection of rape drugs based on the colorimetric analysis thereof, as well as the method for use thereof.

IPC Classes  ?

• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators
• G01N 33/14 - Beverages
• G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator

Abstract

The present invention relates to substituted 1,2,3-triazoles of formula (I) useful for the treatment of ocular diseases, in particular those related to retinal degeneration. The invention also relates to pharmaceutical compositions to treat retinal diseases via topic administration.

IPC Classes  ?

• A61K 31/4192 - 1,2,3-Triazoles
• A61P 27/02 - Ophthalmic agents
• C07D 249/04 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to coordination compounds, specifically to lanthanide coordination compounds that are proven to be useful as anti-inflammatory agents. The present invention further relates to novel gadolinium coordination compounds.

IPC Classes  ?

• C07C 229/42 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
• C07C 229/76 - Metal complexes of amino carboxylic acids
• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• C01F 17/20 - Compounds containing only rare earth metals as the metal element

Abstract

The present invention provides a system for the maintenance and sterilization of oil emulsions housed within a reservoir, said reservoir comprising a lower base according to the direction of gravity and an opening opposite said lower base, the system comprising: a supporting structure configured to be arranged, at least partially, in an operating mode of the system, over the opening of the reservoir; at least one UV lamp arranged on the supporting structure; and at least one conduit configured to be inserted, at least partially, in an operating mode of the system, inside the reservoir, wherein said conduit is configured to establish fluidic communication between a source of compressed air and the interior of the reservoir through at least one compressed air diffusion means provided in the conduit.

IPC Classes  ?

• A61L 2/10 - Ultraviolet radiation

Abstract

Composition includes: (A) a mixed oxide of lithium, nickel, manganese and cobalt and (B) a fluorinated anion salt of a polycationic polymer. The fluorinated anion salt of the polycationic polymer contains repeating units represented by one of formula (1) or formula (2): Composition includes: (A) a mixed oxide of lithium, nickel, manganese and cobalt and (B) a fluorinated anion salt of a polycationic polymer. The fluorinated anion salt of the polycationic polymer contains repeating units represented by one of formula (1) or formula (2): Composition includes: (A) a mixed oxide of lithium, nickel, manganese and cobalt and (B) a fluorinated anion salt of a polycationic polymer. The fluorinated anion salt of the polycationic polymer contains repeating units represented by one of formula (1) or formula (2): wherein, in the formula (1), N+ is a nitrogen atom constituting a quaternary ammonium cation, R1 and R2 being each independently a substituent containing a carbon atom bonded to the nitrogen atom, Composition includes: (A) a mixed oxide of lithium, nickel, manganese and cobalt and (B) a fluorinated anion salt of a polycationic polymer. The fluorinated anion salt of the polycationic polymer contains repeating units represented by one of formula (1) or formula (2): wherein, in the formula (1), N+ is a nitrogen atom constituting a quaternary ammonium cation, R1 and R2 being each independently a substituent containing a carbon atom bonded to the nitrogen atom, Composition includes: (A) a mixed oxide of lithium, nickel, manganese and cobalt and (B) a fluorinated anion salt of a polycationic polymer. The fluorinated anion salt of the polycationic polymer contains repeating units represented by one of formula (1) or formula (2): wherein, in the formula (1), N+ is a nitrogen atom constituting a quaternary ammonium cation, R1 and R2 being each independently a substituent containing a carbon atom bonded to the nitrogen atom, wherein, in the formula (2), R3 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms.

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 10/0569 - Liquid materials characterised by the solvents
• H01M 10/0568 - Liquid materials characterised by the solutes
• H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds
• H01M 12/08 - Hybrid cellsManufacture thereof composed of a half-cell of a fuel-cell type and a half-cell of the secondary-cell type

Abstract

Method for producing energy by means of a supercritical carbon dioxide (sCO2) regenerative Brayton cycle with N recuperators in series and N or N-1 auxiliary compressors, where N ≥ 3. By using a higher number of recuperators in series and an auxiliary compressor for each recuperator, the heat recovery process is improved and thus the performance of the cycle compared to the cycles of the state-of-the-art.

IPC Classes  ?

• F01K 25/10 - Plants or engines characterised by use of special working fluids, not otherwise provided forPlants operating in closed cycles and not otherwise provided for using special vapours the vapours being cold, e.g. ammonia, carbon dioxide, ether
• F22B 3/08 - Other methods of steam generationSteam boilers not provided for in other groups of this subclass at critical or supercritical pressure values
• F02C 1/10 - Closed cycles

Abstract

The present invention relates to an in vitro method for the diagnosis of melanoma in a subject based on the determination of the level of at least one lipid biomarker. The invention also relates to a computer implemented method for the diagnosis of melanoma, and to a computer program comprising computer-readable instructions for executing said method.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The invention relates to a test apparatus comprising a housing (2) with an interior which forms a watertight main measuring chamber (3) for housing a bar (4), a framework structure (6) supporting the housing (2), a sample holder arranged in the main chamber (3), and an air-conditioning system for obtaining regulated relative humidity and temperature conditions for the air inside the main chamber (3). The apparatus also comprises a humidifying system, a thermal regulation system, and a humidified air recirculation system. The sample holder comprises first lower support elements (7) for supporting a first end part of the sample bar (4) and second lower support elements (8) for supporting a second end part of the sample bar (4) corresponding to the unsealed end face (4a) of the sample bar (4). A first suspension arm and a second suspension arm (9, 10) are each hinged at their lower end to one of the lower support elements (7, 8), the first suspension arm (9) being hinged to an upper part of the framework structure (6), and the second suspension arm (10) being hinged such that it is connected to a force gauge (15) arranged in the main chamber (3), the lower support elements (7, 8) being suspended on the suspension arms (9, 10) such that they keep the sample bar (4) axially suspended in a horizontal plane without causing axial stresses in the bar (4).

IPC Classes  ?

• G01N 17/00 - Investigating resistance of materials to the weather, to corrosion or to light

Abstract

The present invention discloses a monocrystalline shape memory alloy consisting of: 11.5 % - 14.0 % Al by weight; 2.5 % - 5.5 % Ni by weight; 0.02 % - 0.58 % Be by weight, the balance being Cu and unavoidable impurities. The alloy of the invention may have a martensitic transformation temperature between 400 K and 4.2 K, by adjusting the concentration of the elements thereof. The invention further discloses a method for preparing the alloy comprising the following steps: (i) Obtaining a first homogeneous alloy from a molten mixture of the Cu, Al, Ni and Be elements under an inert atmosphere; (ii) Placing an oriented monocrystalline seed, having a concentration similar to that of the monocrystalline shape memory alloy to be obtained, in a monocrystal growth equipment, by means of the vertical Bridgman or other growth method, and growing an oriented monocrystal by incorporating the first alloy obtained in step (i) into the equipment; (iii) Subjecting the monocrystal obtained in the preceding step, in a precipitated state, to a solubilisation treatment; (iv) Subjecting the monocrystal obtained in the preceding step to a tempering treatment, and (vi) subjecting the monocrystal obtained in the preceding step to an aging treatment until the monocrystalline shape memory alloy is obtained. The invention also discloses various uses of the alloy under temperature conditions from 400 K to 4.2 K.

IPC Classes  ?

• C22C 1/02 - Making non-ferrous alloys by melting
• C22C 9/01 - Alloys based on copper with aluminium as the next major constituent
• C22F 1/08 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of copper or alloys based thereon
• C30B 11/00 - Single-crystal-growth by normal freezing or freezing under temperature gradient, e.g. Bridgman- Stockbarger method
• C30B 29/52 - Alloys
• C22C 1/03 - Making non-ferrous alloys by melting using master alloys

Abstract

System (1) for diagnosing the balance of a user or patient, comprising: a platform (2, 21), a U-shaped support structure (3), and at least three linear actuators (A1, A2, A3); characterized in that the U-shaped support structure (3) partially surrounds the sensor-equipped platform (2), allowing a user to access the platform (2), and in that the structure includes guiding elements (70) for guiding the movable ends (211, 221, 231) of the actuators, which allow the movable ends to move vertically with respect to the structure (3), said movable ends (211, 221, 231) being mechanically connected to the platform (2, 21) such that when the movable ends (211, 221, 231) move vertically, they cause the platform (2, 21) to move.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes

Goods & Services

Software; Education software; Mobile software; Student software; Computer software; Intranet software; Extranet software; Document management software; Computer software platforms, recorded or downloadable; Downloadable educational media; Downloadable educational course materials; Teaching apparatus; Audiovisual teaching apparatus; Teaching apparatus and instruments; Electronic publications, downloadable; Compact discs; Magnetic data media; Optical data media. Agendas; Annuals [printed publications]; Files [office requisites]; Binders; Printing and bookbinding equipment; Stationery; Pads [stationery]; Ball pens; Calendars; File folders; Newsletters; Writing or drawing books; Pamphlets; Prints; Books; Pencils; Educational books; Manuals [handbooks]; Manuals for instructional purposes; Printed matter, and stationery and educational supplies; Printed educational materials; Office stationery; Teaching materials [except apparatus]; Educational equipment; Educational and instructional material; Pens [office requisites]; Stationery and educational supplies; Magazines [periodicals]; Educational publications; Printed publications; Periodicals. Academies [education]; Conducting of classes; Conducting of educational events; Conducting of live sports events; Consultancy services relating to training; Provision of training courses; Providing of further training courses; Postgraduate training courses; Courses (Training -) relating to research and development; Written training courses; Providing computer assisted courses of instruction; Postgraduate training courses relating to engineering technology; Postgraduate training courses relating to management studies; Providing training courses on business management; Training courses relating to computer software; Provision of training courses in personal development; Training courses in engine design; Courses (Training -) relating to religious subjects; Courses (Training -) relating to science; Courses (Training -) relating to law; Courses (Training -) relating to accountancy; Training courses relating to computer hardware; Courses (Training -) relating to insurance; Courses (Training -) relating to engineering; Courses (Training -) relating to banking; Training courses relating to database designs; Courses (Training -) relating to management; Courses (Training -) relating to finance; Training courses relating to system analysis; Courses (Training -) relating to medicine; Courses (Training -) relating to philosophical subjects; Training courses in strategic planning relating to advertising, promotion, marketing and business; Language courses; Instruction courses relating to health; Provision of courses of instruction relating to sport; Educational courses relating to design; Education courses relating to automation; Educational courses relating to finance; Courses for the development of consulting skills; Correspondence courses; Development of educational materials; Conducting instructional courses; Conducting of educational courses; Conducting of educational courses relating to business management; Conducting of educational courses relating to business; Conducting courses, seminars and workshops; Conducting workshops [training]; Editing of written texts; Issue of publications; Online publication of electronic books and journals; Video editing; Publication of educational texts; Publishing services for books and magazines; Teaching; Education and instruction; Education, entertainment and sports; Development of educational courses and examinations; Language tuition; Educational testing; Provision of education courses; Providing online electronic publications, not downloadable; Training; Further education; Provision of education on-line from a computer database or via the internet or extranets; Provision of training and education; Training and instruction; Management of education services; Providing courses of instruction at college level; Providing courses of instruction at post-graduate level; Conducting distance learning instruction at the university level; Conducting distance learning instruction at the graduate level; Publication of books; Arranging for students to participate in educational activities; Organisation of educational events; Organisation of training; Organising of educational lectures; Arranging of classes; Organization of educational congresses; Arrangement of conventions for educational purposes; Organisation of training courses; Organisation of language courses; Organisation of events for cultural, entertainment and sporting purposes; Organisation of seminars and conferences; Organisation of seminars relating to education; Providing of education; Publishing of instructional books; Publication of instructional literature; Electronic publication of texts and printed matter, other than publicity texts, on the Internet; Conducting of courses; Lending library services; Online academic library services; Education and instruction services; Education services in the nature of courses at the university level; Workshops for training purposes; Provision of online training; Providing of training, teaching and tuition; University education services; University services; Educational services provided by universities; Educating at university or colleges; Engineering training college services.

Abstract

The present invention relates to a process for preparing a crystalline calcium silicate from a calcium silicate hydrate under hydrothermal conditions.

IPC Classes  ?

• C01B 33/24 - Alkaline earth metal silicates

Abstract

The present invention has discovered that a sponge-like scaffold comprising soy protein, chitin and a plasticizer has ideal physiochemical and mechanical properties for use as a haemostasis promoter. Therefore, the present invention provides the use of said scaffold for the use in promoting haemostasis in wounds, preferably haemorrhages such as nasal haemorrhage, as well as products which comprise said scaffold for use in promoting haemostasis.

IPC Classes  ?

• A61L 15/28 - Polysaccharides or their derivatives
• A61L 15/40 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof
• A61L 15/42 - Use of materials characterised by their function or physical properties
• A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
• A61L 24/08 - Polysaccharides
• A61L 24/10 - PolypeptidesProteins

Abstract

The inventors of the present invention have developed a support that couples the controlled seeding of cells into predetermined patterns with the presentation and/or detection of molecules of interest to/from said cells. Said support is characterized for containing predetermined patterns where cells adhere to and have a uniform layer of microbeads functionalized with a molecule of interest.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

Abstract

The present invention relates to compounds of BODIPY structure having good properties for the specific fluorescent labelling of C-nucleophiles and to the process of obtainment thereof, which enables the efficient and economic preparation of a great diversity of compounds in a direct, fast way and with good reaction yields. The application of these compounds includes, but is not limited to, their use as biomarkers for selective staining of living cells and microorganisms, as fluorescent probes in biosensors in bioimaging of living organisms or energy scavengers in solar cells, or as emitters in dye lasers or as emitters in OLED systems.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
• H01L 51/50 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED)

Abstract

Disclosed is an apparatus and a method. Spin-splitting is induced at a superconductor and spin-polarization facilitated for tunneling across a tunnel barrier so that electric current across the tunnel barrier between a conductor and the superconductor flows primarily in one direction.

IPC Classes  ?

• H01L 39/02 - Devices using superconductivity or hyperconductivity; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof - Details
• H01L 39/22 - Devices comprising a junction of dissimilar materials, e.g. Josephson-effect devices
• H01L 43/08 - Magnetic-field-controlled resistors

Abstract

The present invention relates to an illumination device and incubator for conducting microalgae growth experiments. The device comprises at least one illumination source (10) having LEDs (20) for illuminating the microalgae and a control unit (30) configured for controlling the switching on/off of the LEDs (20) and for varying the light intensity of the LEDs (20). The illumination source (10) comprises RGB LEDs (20) and each RGB LED (20) has a casing that houses a red (21), green (22) and blue (23) LED and a microcontroller (24) that is connected to the control unit (30) for varying the light intensity of the red (21), green (22) and blue (23) LEDs of the RGB LED (20), such that the colour and intensity of the light emitted by each RGB LED (20) is modified by means of the control unit (30).

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors

Abstract

An optical fiber comprising: a first optical fiber and a second optical fiber; the first optical fiber comprising a core extending between ends of the first optical fiber, and being a single mode fiber; the second optical fiber comprising a first core extending between first and second ends of the second optical fiber, and a second core extending between the first and second ends; the second core being apart from the first core such that there is optical coupling between the first and second cores; the second optical fiber being connected to the first optical fiber at the first end such that the first core is connected with the core of the first optical fiber and the second core not being connected with any core of the first optical fiber; the first core is at a central axis of the second optical fiber, i.e. the central axis of the first core coincides with the central axis of the second optical fiber; and the first and second cores each comprising a fiber Bragg grating having a same reflection wavelength, the two fiber Bragg gratings extending a same length and being positioned at a same distance from the first end.

IPC Classes  ?

• G01D 5/353 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells influencing the transmission properties of an optical fibre

Abstract

The present invention refers to a process for preparing carbonyl-containing compounds of formula (Ia), (Ib) or (Ic) from Bisphenol A-based Polycarbonate and appropriate nucleophiles in the presence of imidazole or a derivative thereof as catalyst and an organic solvent.

IPC Classes  ?

• C07D 239/10 - Oxygen or sulfur atoms
• C07D 319/06 - 1,3-DioxanesHydrogenated 1,3-dioxanes not condensed with other rings
• C08G 63/00 - Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
• C07C 68/00 - Preparation of esters of carbonic or haloformic acids
• C07C 273/18 - Preparation of urea or its derivatives, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas

Abstract

Disclosed herein are compositions comprising globular proteins and diacrylate-containing compounds that can react in-situ to provide polymerized networks that can be formed into objects using additive manufacturing techniques, such as printing techniques that use vat photopolymerization. Objects printed using the disclosed compositions also are described, with embodiments of such objects exhibiting shape recovery behavior. Also disclosed are methods of making and using the disclosed compositions.

IPC Classes  ?

• C09D 11/04 - Printing inks based on proteins
• C09D 11/101 - Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
• C09D 11/102 - Printing inks based on artificial resins containing macromolecular compounds obtained by reactions other than those only involving unsaturated carbon-to-carbon bonds
• C08F 2/10 - Aqueous solvent
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers

Abstract

112312312111 are electron donor or electron acceptor groups having a REDOX potential between +2.70 to -2.5 V as determined by cyclic voltammetry using an Ag/AgCl electrode as reference. The invention also provides processes for its preparation as well as kits and devices comprising the catalytic system, as well as its use in the fields of therapy and diagnostics.

IPC Classes  ?

• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 37/02 - Impregnation, coating or precipitation

Abstract

The present invention relates to the field of the diagnosis and/or prognosis of eosinophilic esophagitis (EoE) in saliva, specifically diagnosis and/or prognosis for the detection and quantification of the expression level of EoE biomarker genes present in the saliva of subjects.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The present invention relates to training aids for training in the detection of explosives, which comprise triacetone triperoxide (TATP) absorbed as a solid or gas into a solid support comprising a cellulose material, in particular cellulose acetate. Also described are methods for producing the training aids of the invention using acetone, hydrogen peroxide and an acid in a molar ratio, and the use of the training aids to train dogs to detect TATP explosives.

IPC Classes  ?

• A01K 15/00 - Devices for taming animals, e.g. nose-rings or hobblesDevices for overturning animals in generalTraining or exercising equipmentCovering boxes
• A01K 15/02 - Training or exercising equipment, e.g. mazes or labyrinths for animals
• C06B 21/00 - Apparatus or methods for working-up explosives, e.g. forming, cutting, drying

Abstract

Method for colorimetric detection of bacteria in food samples Method for colorimetric detection of bacterial nucleases in biological and food samples through the use of a hemi-methylated duplex linker and functionalized nanoparticles which, depending if nucleases are present in the sample or not, disperse or aggregate leading to a naked eye visible change in the colour of the solution.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

in vitro in vitro method and kits for the prognosis of amyotrophic lateral sclerosis (ALS), based on the expression or activity of ELOVL6 ( Elongation of Very Long chain fatty acids protein 6).

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Model-based predictive control method (MPC) for the reduction of structural load in wind turbines, comprising: exclusively proposing a single linear internal model for the MPC for the entire operating range of the turbine; obtaining the adjustable parameters of the linear internal model from the experimental data previously measured in the turbine; choosing the discrete time values for the control and prediction horizons; adjusting the MPC controller and performing a practical implementation test.

IPC Classes  ?

• G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
• F03D 7/04 - Automatic controlRegulation

Abstract

An anti-corona ring 10a, 10b for an electrical conductor 2a-2d, comprising a first device 11a and a second device 11b, the first and second devices 11a, 11b being suitable for forming a first ring 14 when joined, wherein the first device 11a comprises first joining means 12a and the second device 11b comprises second joining means 12b, the first and second joining means 12a, 12b being suitable for cooperating in joining the first and second devices 11a, lib; as well as comprising third and fourth devices 16a, 16b joined to the first and second devices 11a, 11b by one or more ribs 15a, 15b, wherein the third and fourth devices 16a, 16b are suitable for forming a second ring 19 when the first and second devices 11a, 11b are joined.

IPC Classes  ?

• H01T 19/02 - Corona rings
• H01B 5/00 - Non-insulated conductors or conductive bodies characterised by their form

Abstract

The invention relates to a sperm selection and sperm analysis method useful in in vitro fertilisation techniques. In particular, the invention relates to a device for the selection of spermatozoa, in addition to a sperm selection or in vitro fertilisation method comprising the use of said device.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12N 5/076 - Sperm cellsSpermatogonia
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors

Abstract

The invention relates to a method for producing crystalline nanocellulose comprising contacting a substrate comprising cellulose with an enzyme comprising an endoglucanase catalytic domain under suitable conditions for hydrolyzing cellulose and under a pH greater than 5, wherein the endoglucanase catalytic domain comprises a sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 and a functionally equivalent variant thereof that substantially maintains or improves its endoglucanase catalytic activity. The invention also relates to crystalline nanocellulose obtained by this method.

IPC Classes  ?

• C12N 9/42 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-1, 4-glucosidic bonds, e.g. cellulase
• C08L 1/02 - CelluloseModified cellulose

Abstract

The present invention refers to a cellulose composite material, methods of preparation and uses thereof. The composite material comprises type I cellulose fibers selected from the group consisting of cellulose nanocrystals and a carbon material selected from the group consisting of carbon nanotubes, carbon nanofibers, graphene, graphene oxide and a mixture thereof. The invention further relates to conductive paint compositions comprising said composite material.

IPC Classes  ?

• C12N 9/42 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-1, 4-glucosidic bonds, e.g. cellulase
• C12P 7/10 - Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• C01B 32/20 - Graphite
• C08K 3/04 - Carbon
• D21H 11/18 - Highly hydrated, swollen or fibrillatable fibres
• D21H 13/50 - Carbon fibres

Abstract

The present invention refers to a process for the selective modification of tyrosine units in a peptide sequence, in particular, by incorporating acyl groups in the ortho position of the hydroxyl residue of its aromatic ring. Likewise, the invention also relates to a peptide sequence comprising at least one mono- or di-functionalized tyrosine unit with said acyl group in the aromatic ring, as well as to a pharmaceutical composition comprising said sequence.

IPC Classes  ?

• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 5/06 - Dipeptides
• C07K 5/062 - Dipeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala

Abstract

The invention provides solid lipid nanoparticles (SLNs) which comprise gold, and are useful as vectors for the transfection of different types of nucleic acids. Different methods for obtaining such SLNs are also disclosed.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to the development of polypeptides useful for the treatment of diseases associated with amyloid deposits, and more specifically for the. The invention also relates to compositions comprising the developed polypeptides and to a method for the identification of compounds useful for the treatment of diseases associated with the formation of amyloid deposits.

IPC Classes  ?

• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof

Abstract

A microfluidic sensor for the detection of analytes in objects is disclosed herein, comprising a contact surface that may be attached to a surface of the object, an inlet orifice in the contact surface for the entry of fluids emitted by the object, and a first reservoir which stores an ionic fluid in the form of a polymer matrix. The polymer matrix comprises a reactive substance which changes colour when it enters into contact with the analytes of the fluids emitted by the object. It further comprises at least one first microfluidic duct which connects the inlet orifice to the first reservoir. Also disclosed are a system for the detection of analytes, a method for the manufacture of the microfluidic sensor and the use of the microfluidic sensor for the detection of analytes in works of art.

IPC Classes  ?

• G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

Abstract

In this invention, we propose a protein probability model derived from analytical considerations that i) integrates the information provided by all identified peptides, that ii) accurately predicts the random behaviour of decoy proteins, and iii) effectively resolves the peptide-to-protein paradox. Our results were validated by analysing the results from three search engines for several tissues from the Human Proteome Map.

IPC Classes  ?

• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to a surface treatment device for dental parts, the dental parts being selected from dental implants, dental abutments and a combination of both. The device comprises a central body formed by three side walls that define a triangular prism-shaped treatment chamber. The three side walls are joined to each other by rounded vertical edges. The treatment chamber is configured to house at least one dental part. The device further comprises a support on which the central body is positioned, a lid coupled to an upper mouth of the central body, a plurality of LED diodes positioned on side walls of the treatment chamber that radiate ultraviolet light on the outer surface of the dental parts and a reflective surface positioned on inner faces of the treatment chamber to reflect ultraviolet light towards the dental parts.

IPC Classes  ?

• A61C 19/00 - Dental auxiliary appliances
• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereonDental implantsImplanting tools
• A61C 13/15 - Curing devices for plastics prostheses for curing by the action of light

Abstract

The present invention relates to methods for diagnosing celiac disease based on the quantification of the level of expression of the UBE2L3 gene and the relative expression of UBE2L3 isoform 2 with respect to the total expression of said gene. The invention also relates to kits with the necessary means for making the diagnosis according to the methods of the invention.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

A device (10,11) comprising: a cam (20,21); a motor configured to rotate the cam (20,21); and at least one assembly (25a-25h) adapted to apply a load on a dental implant (55a-55h), each assembly (25a-25h) of the at least one assembly comprising: a support (50) adapted to support a dental implant (55a- 5h); a guide (38) arranged between the cam (20,21) and the support of the assembly (25a-25h); a first element (32) arranged on the guide (38) of the assembly (25a-25h) and adapted to contact the dental implant (55a-55h) in the support (50) of the assembly (25a-25h); a second element (34) arranged on the guide (38) of the assembly (25a-25h) and in contact with the cam (20,21), the second element (34) being adapted to move along the guide (38) of the assembly (25a-25h); and a spring (30) arranged on the guide (38) of the assembly (25a-25h) and comprising a first end and a second end, the first end being coupled to the first element (32) of the assembly (25a-25h) and the second end being coupled to the second element (34) of the assembly (25a- 25h). The invention also relates to a method for testing dental implants with the device.

IPC Classes  ?

• G01N 3/34 - Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces generated by mechanical means, e.g. hammer blows
• A61C 19/04 - Measuring instruments specially adapted for dentistry

Abstract

The present invention provides a serum-free endothelial cell differentiation culture medium comprising (a) a basal culture medium and (b) an endothelial cell differentiation combination of EGF,FGFand VEGF protein, wherein the amount of EGF is higher than the amount of FGF protein. The present invention further provides a process for the preparation of cellular aggregate suspensions comprising differentiated endothelial cells from dental stem cells using the serum-free medium, as well as the use of the resulting suspension in therapy.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

22R322R411010-alkyl, or C(=O)OR511010-alkyl, R211010-alkyl, R311010-alkyl, R411010-alkyl, R512020-alkyl. The invention also relates to an aqueous polymer dispersion obtainable by such a process as well as the use of such dispersions.

IPC Classes  ?

• C08F 2/22 - Emulsion polymerisation
• C09D 151/00 - Coating compositions based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCoating compositions based on derivatives of such polymers
• C08F 265/06 - Polymerisation of acrylate or methacrylate esters on to polymers thereof
• C08L 51/00 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers

Abstract

2473323232322); to the preservative obtainable by means of this method; and to a method for preserving wood; and to the preserved wood according to the invention. The preservative of the invention prevents degradation by means of xylophagous and fungal agents, and also improves some properties of the wood, and the hygroscopicity and fire resistance.

IPC Classes  ?

• A01N 59/14 - BoronCompounds thereof
• A01N 59/16 - Heavy metalsCompounds thereof
• A01N 59/20 - Copper
• A01N 61/00 - Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
• B27K 3/15 - Impregnating involving polymerisation
• B27K 3/16 - Inorganic impregnating agents
• B27K 3/22 - Compounds of zinc or copper
• B27K 3/26 - Compounds of iron, aluminium, or chromium
• A01P 3/00 - Fungicides

Abstract

The invention describes a new general method for the aerobic rupture or oxidation of compounds having a tertiary carbon directly bonded to an aryl group, and polymers based on said structural monomeric unit, to provide the corresponding aryl ketone by means of the exclusive use of molecular oxygen as an oxidising agent.

IPC Classes  ?

• C07C 45/36 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by oxidation with molecular oxygen of CHx-moieties in unsaturated compounds in compounds containing six-membered aromatic rings
• C07C 49/76 - Ketones containing a keto group bound to a six-membered aromatic ring
• C07D 249/08 - 1,2,4-TriazolesHydrogenated 1,2,4-triazoles

Abstract

The present invention relates to a method for diagnosing unstable atherosclerosis plaques, using a method to determine the probability of a person suffering from a cerebrovascular disease and a method to select a patient that could be treated with a therapy to eliminate or stabilise the carotid atherosclosis plaque on the basis of the determination of the expression level of at least one gene selected from the group of genes shown in table 1. The invention also relates to a kit comprising suitable reagents for determining the expression levels of at least one gene selected from the group of genes shown in table 1 and, optionally, reagents for determining the expression levels of one or more caretaker genes, and to the uses of said kit.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The invention relates to a source (4) confinement means (1) for a contactor (2) of a fluidised bed (3) and to a contactor of a fluidised bed comprising: a particle bed (3), an inlet (21) for gas for the treatment of the particles; an outlet (22) for the gas after the treatment of the particles; a contact chamber (23) for permitting contact between the gas and the particles. The confinement means (1) comprises: a peripheral wall (12) to form a cavity (11) inside the contact chamber (23), which has an opening (13) facing the inlet (21) and the bed (3), in order to direct an inlet and outlet of gas and particles via the opening (13), with the inlet for gas and particles into the cavity (11) being in an ascending direction, and the outlet for gas and particles out of the cavity (11) being in a descending direction.

IPC Classes  ?

• B01J 8/24 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with fluidised particles according to "fluidised-bed" technique

Abstract

The invention refers to the medical treatment of irreversible-type dementias, and more particularly to the use of a family of cannabinoid agonists to treat the impaired cognitive functions resulting from said dementias.

IPC Classes  ?

• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to a set of markers, preferably proteins, all associated with the path of the system for activating the complement, which are particularly useful for predicting and/or forecasting the compatibility in vitro of a biomaterial, for example such as prosthetic joints, dental prostheses, valves, stents, etc. in the patient. In addition, the present invention comprises an in vitro method for predicting and/or forecasting the compatibility of said materials by determining the peptide profile described in the invention, as well as a kit and/or a device for carrying out said method.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The present invention provides a method for detecting the presence or absence of a target analyte in a test sample, comprising the steps: i) providing a plurality of detector nanoparticles comprising a first detector nanoparticle functionalised with a first probe specific for a first region of a target analyte and a second detector nanoparticle functionalised with a second probe specific for a second region of said target analyte; and ii) contacting said detector nanoparticles with a test sample under conditions suitable for the binding of the specific probes to the target analyte, wherein target analyte-induced agglomeration of the detector nanoparticles permits the release of a detectable signal means from a signal reservoir. Also provided are related devices and systems for performing the method of the invention.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The present invention relates to a method for producing a dispersion comprising composite particles, wherein the nanocomposite particles comprise: a core comprising a polymeric material matrix and organically modified magnetic nanoparticles embedded within said matrix; and a coating comprising photocatalytic nanoparticles around the core. The particles of the invention may be prepared by Pickering miniemulsion polymerization and can be applied inter alia in the field of water treatment, in air decontamination and in antibacterial coatings.

IPC Classes  ?

• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 23/745 - Iron
• B01J 23/78 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with alkali- or alkaline earth metals or beryllium
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• B01J 37/04 - Mixing
• B01J 37/02 - Impregnation, coating or precipitation
• B01D 53/88 - Handling or mounting catalysts
• C02F 1/48 - Treatment of water, waste water, or sewage with magnetic or electric fields

Abstract

The present invention relates to an in vitro method for the prognosis or prediction of the response to treatment with anti-psychotic drugs in subjects who have suffered first episode psychosis (FEP), and specifically to the use of the expression value, in a biological sample isolated from said subjects, of the ratio formed by two of the isoforms – active isoform and truncated isoform – of the receptor (TrKB) of the nerve growth factor BDNF, named TrKB-FL and TrkB-T, respectively. The present invention also describes kits and uses of same to implement the method of the invention.

IPC Classes  ?

• G01N 33/536 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to a nucleic acid molecule encoding a fusion protein, said nucleic acid molecule comprising, in transcription direction 5´---3´, at least: one nucleic acid sequence encoding a DNA-binding domain; and a nucleic acid sequence encoding a FokI-type catalytic domain, the 3' end thereof comprising a nucleic acid sequence encoding a peptide comprising between 18 and 23 amino acids. The invention also relates to a fusion protein that can be obtained, for example, from the transcription of said molecule, and to a method for altering the genetic material of a cell using said molecule or protein.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

The invention relates to: a lipid nanoparticle comprising at least one tobramycin antibiotic, a lipid fraction, and one or more surfactants; and the use of the nanoparticle in the prevention and/or treatment of infections of the respiratory tree.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
• A61P 31/04 - Antibacterial agents
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• C08G 64/16 - Aliphatic-aromatic or araliphatic polycarbonates

Abstract

The invention relates to a lipid nanoparticle comprising at least one antibiotic from the polymyxin family, a lipid fraction and one or more surfactants, and to the use of the nanoparticle in the prevention and/or treatment of infections in the respiratory system.

IPC Classes  ?

• A61K 38/12 - Cyclic peptides
• A61K 9/51 - Nanocapsules

Abstract

The invention relates to biodegradable PLGA bionanoparticles encapsulating the GSE24-2 peptide with telomerase activity, and to pharmaceutical, cosmetic and biotechnological compositions comprising same. The pharmaceutical compositions are useful for treating diseases presenting a telomerase deficiency, such as dyskeratosis congenita, and diseases presenting ageing characteristics, such as Werner syndrome, Rothmund Thompson syndrome, and other diseases where there is DNA damage such as ataxia telangiectasia. The relation also relates to the method for producing said bionanoparticles by means of a w/o/w double emulsion technique.

IPC Classes  ?

• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The invention relates to the use of metal nanoparticles deposited on a substrate by means of cathode sputtering as a catalyst for the synthesis of nanostructures. The nanoparticles deposited on the substrate have catalytic activity for the synthesis of nanostructures. The invention also relates to a method for the synthesis of nanostructures on said nanoparticles.

IPC Classes  ?

• B01J 23/00 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group
• B01J 37/00 - Processes, in general, for preparing catalystsProcesses, in general, for activation of catalysts
• B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• C01B 31/02 - Preparation of carbon; Purification

Abstract

The invention relates to a method for depositing metal nanoparticles on any type of substrate by means of cathode sputtering, in which the deposition is performed at a power density of between 0.2-5 W/cm2 at a pressure between 60 and 180 Pa, in the presence of a noble gas. Using the method of the invention, it is possible to deposit nanoparticles on any type of substrate (polymers, fibres, silicon, etc.) at low temperatures, in particular ambient temperatures, without deposition area limits and without deposition time restrictions. Following the deposition, by inverting the polarity, it is possible to produce areas of roughness on a nanometric scale on the substrate.

IPC Classes  ?

• C23C 14/34 - Sputtering
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

The present invention relates to a hybrid photoactive material which includes at least one dye having fluorescent properties and a structure having the general formula (I), which is an aromatic molecule and the resonant forms thereof; where X is selected from CH or N and Y is selected from the group made up of S, O, N, CH and NH; such that when X=CH, Y is selected from S, O, N, CH or NH, and when X=N, then Y=0; n being equal to +1 when Y=O, NH or S and n being equal to 0 when Y=N or CH; R1, R2, R3 and R4 can be mutually identical or different and selected from: H, CH3, CH2CH3 or N(R11) (R12), where R11 and R12 are mutually identical or different and selected from the group made up of: H, CH3 and CH2CH3; said dye being contained and encapsulated in a crystalline porous material with magnesioaluminophosphate (MgAPO) composition, characterised by having pores with a first diameter in the interval of 4 to 7 Å, both limits included, and a second diameter in the interval of 4 to 7.5 Å, both limits included, which has a one-way system of channels defined by rings of ten to twelve atoms of Al and P with tetrahedral coordination. The invention further relates to a method for preparing the previously defined hybrid material, and to the uses of said hybrid material.

IPC Classes  ?

• C01B 39/54 - Phosphates, e.g. APO or SAPO compounds
• C01B 39/00 - Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolitesTheir preparationAfter-treatment, e.g. ion-exchange or dealumination
• B01J 29/84 - Aluminophosphates containing other elements, e.g. metals, boron
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

The invention relates to a method for picking up information for virtual deployment and to a related device, which includes a main body that enables the collection of information via a means for collecting information in order to perform the computer-assisted simulation, in which said main body includes a first portion that makes it possible to couple same to the element to be picked up, and in which said main body also includes a second portion that enables the device to be the target of the information-collection means, which in association with another information-collection means positioned on the element to be picked up, makes it possible to obtain optimum reference coordinates for a computer-assisted system.

IPC Classes  ?

• A61C 11/00 - Dental articulators, i.e. for simulating movement of the temporo-mandibular jointsArticulation forms or mouldings

Abstract

The invention relates to an osteoinductive coating for use in dental implants, which can be obtained, using a sol-gel process, from methyltrimethoxysilane (MTMS) as a silicon base precursor, ethyl tetraorthosilicate (TEOS) as a hydrophilic silicon precursor and at least one silicon precursor selected from glycidoxypropyltrimethoxysilane and aminopropyltrimethoxysilane. The invention also relates to the method for obtaining said coating and to the use thereof in dental implants.

IPC Classes  ?

• A61L 27/34 - Macromolecular materials
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 31/10 - Macromolecular materials
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances
• C23C 18/02 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition
• C09D 183/04 - Polysiloxanes

Abstract

An apparatus for obtaining energy from the waves by means of an impelled air column, for the generation of electrical energy, which comprises a submerged main body secured to a base anchored to the sea bed, where the turbogenerator unit for generating electrical energy is located, a piston for actuating air circulation, means for stabilizing the stream of air passing through the turbogenerator turbine and means for tidal adjustment. In turn, there is a floating buoy as wave‑energy‑capture mechanism, the undulating movement of the buoy, which is connected to the main body by means of connection means, being that which actuates the piston that creates the air stream that activates operation of the turbogenerator unit.

IPC Classes  ?

• F03B 13/24 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy to produce a flow of air, e.g. to drive an air turbine

Abstract

The invention relates to a controllable frequency, broad spectrum light emitting source that includes boron nitride nanotubes with defects produced by the absence of a boron atom in the tubular structure and wherein the source is additionally provided with a means for generating an electrical field perpendicular to the tube. The invention may be used as a field effect transistor (adding electrodes) or as a source of conversion of energy of an incident bundle.

IPC Classes  ?

• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals

Abstract

The invention relates to a controller comprising a MIDI configuration and communication device (5), and a wind instrument simulator (1). The simulator (1) comprises a casing (11) containing fingering sensors (2) and a mouthpiece (6) with an air flow passage (62) for air blown by the performer, said mouthpiece (6) containing a sensor for detecting the speed of the air flow so that the MIDI configuration and communication device (5) can determine the notes and effects created by said mouthpiece (6) and the sensors (2) that are arranged analogously to a reference acoustic instrument. The sensor for detecting the speed of the air in the mouthpiece (6) is a pressure sensor (3) associated with a canula (31) for measuring the dynamic pressure produced by the air flow during the articulation of a musical note.

IPC Classes  ?

• G10H 1/00 - Details of electrophonic musical instruments
• G10H 3/16 - Instruments in which the tones are generated by electromechanical means using mechanical resonant generators, e.g. strings or percussion instruments, the tones of which are picked up by electromechanical transducers, the electrical signals being further manipulated or amplified and subsequently converted to sound by a loudspeaker or equivalent device using mechanically actuated vibrators with pick-up means using a reed
• G10D 7/00 - General design of wind musical instruments

Abstract

The invention relates to a method for obtaining a polymer sol-gel coating from at least one silicon precursor. The invention is characterised in that it comprises the following steps: (a) the dissolution and hydrolysis of at least one silicon precursor; (b) the preparation of at least one solution and/or dispersion of at least one substance selected from a group containing bioactive particles, drugs and peptides, as well as any combinations thereof; (c) the mixing of the solution obtained in step (a) with at least one solution and/or dispersion obtained in step (b); (d) the application of the mixture obtained in step (c) to at least one substrate, producing a coated substrate; and (e) the drying and curing of the coated substrate obtained in step (d). The invention also relates to a polymer sol-gel coating that can be obtained using said method, a substrate comprising same and the biomedical use thereof.

IPC Classes  ?

• A61L 27/34 - Macromolecular materials
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 31/10 - Macromolecular materials
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances
• C23C 18/02 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition
• C09D 183/04 - Polysiloxanes

Abstract

Method for supplying metallic material to a component (1), which comprises the following steps of a) supplying metallic material, by means of a process for melting the metallic material using heat, at least partially on the surface of said component (1), forming a layer (3) of metallic material and a thermally affected zone, and b) polishing said layer (3) and wherein steps a) and b) are performed by means of at least one combined head (5) that comprises at least one device (2) for supplying said metallic material and at least one polishing tool (4), the two steps being carried out with sufficient delay for the thermally affected zone to still be at a temperature at which the compressive creep stress is less than the polishing pressure.

IPC Classes  ?

• C23C 24/10 - Coating starting from inorganic powder by application of heat or pressure and heat with intermediate formation of a liquid phase in the layer

Abstract

Bidirectional direct-current electrical transmission module characterized in that it comprises, inter alia, a high-frequency bidirectional resonant DC-AC converter, a high-frequency high-voltage step-up transformer, and a direct-voltage bus to power said converter. The use of high-frequency transformers helps to reduce the size thereof by at least one order of magnitude.

IPC Classes  ?

• H02J 3/36 - Arrangements for transfer of electric power between ac networks via a high-tension dc link

Abstract

The invention relates to a system for eliminating current surges that includes a first voltage regulator (7) having a current limit programmable to a value (l(|imite)) that depends on the value of the intermittent current surges (lo(p¡∞))required by the intermittent load (3) and the relationship thereof to the work cycle, a second voltage regulator (9), a condenser (4) connected between the first and second regulators (7, 9), that loads when the current is no longer required and that unloads when there is a need for output current to provide current to the second regulator (9), which absorbs the changes in voltage produced by the loading/unloading of the condenser and provides a constant voltage for any value of the required output current surge, independently of voltage changes in the condenser (4), and a control loop between a sensor for the output current provided to the load and an input limit (15) for the input current (II) in the first regulator (7). Thus, the input current (l(limit))(1 ) and the output voltage (VLoad) are constant for any value of the output current surge (lo(surge)).

IPC Classes  ?

• G05F 1/614 - Regulating voltage or current wherein the variable actually regulated by the final control device is DC using semiconductor devices in parallel with the load as final control devices including two stages of regulation, at least one of which is output level responsive

Abstract

The invention relates to a system for monitoring the ampacity of overhead power lines, which includes monitoring modules (7) installed in respective sets of spans (14) and a remote unit (16) which receives and processes sets of measured data (13) received from the modules, each sensor arrangement being assigned to a set of spans (14), each one of which includes a traction sensor (6), an electric intensity meter (8), an ambient temperature sensor (9) and a solar radiation sensor (10); the data processing unit (16b) calculates the ampacity (AC) for each set of spans (14) according to each set of measured values (13) received, as well as a conductor traction-temperature reference (Ref-TT), the deformation by creeping (DF) and the maximum acceptable temperature (Tmax) of the conductor (2) for each set of spans (14) according to each set of measured values (13).

IPC Classes  ?

• G01R 31/02 - Testing of electric apparatus, lines, or components for short-circuits, discontinuities, leakage, or incorrect line connection
• G01K 1/02 - Means for indicating or recording specially adapted for thermometers

Abstract

A description is given of a storage system for overhead spaces, which comprises an upward and downward housing (20), a platform in contact with the housing; a framework (40); a cable (50) with upward and downward movement together with the upper wall (22) of the housing (20) in order to cause the latter to ascend and descend; at least one telescopic post (60) that has a lower end (61) mounted on the platform (30), and an upper end (62) mounted on the framework (40); and means for extending and retracting the cable such that the means cause the housing (20) to descend and to ascend from a storage position in the overhead space (11) to a lower position in which a user has access to the contents of the housing (20), and vice versa.

IPC Classes  ?

• A47B 51/00 - Cabinets with means for moving compartments up and down

Abstract

The photovoltaic device has a plurality of layers (11, 12, 13) configured in order to convert light (L) into electrical power. Each layer comprises at least one solar cell (11A; 12A, 12B; 13A, 13B, 13C, 13D). Each layer is configured so as to have a bandgap of predetermined width, the width of the bandgap of each layer being different from the width of the bandgap of the other layers. At least one of the layers (12, 13) comprises at least two solar cells (12A, 12B; 13A, 13B, 13C, 13D) connected in series and having bandgaps of the same width. The layers are connected together in parallel such that the tension (U) on each layer (11, 12, 13) is the same. The invention likewise relates to a photovoltaic panel.

IPC Classes  ?

• H01L 31/05 - Electrical interconnection means between PV cells inside the PV module, e.g. series connection of PV cells

Abstract

The invention relates to the field of biotechnology and medicine. The invention specifically relates to a compound comprising a liposome covered or decorated at least with the extracellular domain of the APO2L/TRAIL protein, and to the use thereof for developing a medicament preferably for the treatment of a cancer or inflammatory or autoimmune diseases, such as rheumatoid arthritis.

IPC Classes  ?

• A61K 9/133 - Unilamellar vesicles
• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
• A61P 35/00 - Antineoplastic agents
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

The invention relates to a method for the preparation of a zeolite-based monolith, comprising the following steps: dry-mixing of zeolite particles and a temporary binder until homogenisation thereof; addition of a dispersion of silica and water; wet-blending and high-shear mixing, until a homogeneous paste is obtained; extrusion moulding of the paste resulting from the previous step; controlled drying of the mould; and high temperature oxidation in order to obtain the monolith. The invention further relates to the use of said monolith as a catalyst, a catalyst support for the chemical conversion of gaseous components or an adsorbent for the physico-chemical separation of one or more components of a mixture of gases.

IPC Classes  ?

• C01B 39/26 - Mordenite type
• C01B 39/38 - Type ZSM-5
• B01J 29/40 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11
• B01D 53/38 - Removing components of undefined structure
• B01D 53/56 - Nitrogen oxides

Abstract

The adrenergic receptors or adrenoceptors are a family of G-protein coupled receptors split into α and β subclasses. The adrenoceptors have important roles in regulating a myriad of physiological conditions and their malfunction has been implicated in the pathophysiology of anumber of diseases. Disclosed herein are a series of novel guanidine and 2-aminoimidazoline compounds which are ligands of the alpha2- adrenoceptor (α2-ARs) subclass of adrenergic receptors. The invention also provides for pharmaceutical compositions comprising the novel compounds. The compounds are suitable for use in the manufacture of medicaments for the treatment of α2-ARs associated disorders, such as depression, schizophrenia, glaucoma and analgesia.

IPC Classes  ?

• C07C 279/18 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
• C07D 233/88 - Nitrogen atoms, e.g. allantoin
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 31/4168 - 1,3-Diazoles having a nitrogen atom attached in position 2, e.g. clonidine
• A61P 25/24 - Antidepressants
• A61P 9/12 - Antihypertensives
• A61P 27/06 - Antiglaucoma agents or miotics

Abstract

Parallel robot with four degrees of free movement which comprises four articulated kinematic chains (1), each of said articulated kinematic chains (1) being linked by a first end to a moving platform (3) configured to hold a tool (4) and a second end to a fixed element (5). Said moving platform (3) comprises a rigid (non-flexible) element, or an element formed by the connection of a series of members in such a way that said connection is rigid and does not allow for relative movement between the different members, therefore forming a single element from a mechanical viewpoint.

IPC Classes  ?

• B25J 17/02 - Wrist joints

Abstract

Integral magnetic compass for establishing deviations in real time, comprising a transparent sphere or cylinder (2), containing, in a hydrocarbon liquid (3), a polyester or silicon disk (4) to which the rose (5) and the magnet (6) are fitted, and combined with a commutation system comprising software contained in a device or chip (7), whose circuit has two inputs: an input (8) for the signal obtained from the magnetic compass (1) itself, obtained by means of a magnetometer (9) or optical reader (10) in assocation therewith, and another input (11) to the signal from the satellite compass (12) or from the gyroscopic compass (13), said circuit also having an output (14) to a display (15) for viewing and storage of the data for the corresponding deviations, thus establishing the deviations chart for the magnetic needle in real time, said output being also optionally applicable to the automatic pilot (16).

IPC Classes  ?

• G01C 17/38 - Testing, calibrating, or compensating of compasses
• G01C 17/08 - Suspending magnetic elements by flotation
• G01C 17/26 - Observing the compass card or needle using electric pick-offs for transmission to final indicator, e.g. photocell

Abstract

The invention relates to polyimides with good piezoelectric properties at high temperatures, having a recurring structural unit with general formula (I), in which X and Y represent hydrogen and cyano, on the condition that when either X or Y is hydrogen, the other is cyano. The invention also relates to a method for preparing said polyimides, as well as to diamines for the preparation thereof and to a method for obtaining said diamines. The invention further relates to the use of the polyimides in a wide range of industrial applications, owing to the fact that said polyimides are flexible, light, have good remanent polarisation values and are stable at high temperatures.

IPC Classes  ?

• C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C07C 217/90 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
• H01L 41/193 - Macromolecular compositions

Abstract

The disclosed method comprises a step during which said waste is subjected to pyrolysis, and a step during which the metal obtained during pyrolysis is recovered. The method is characterised in that pyrolysis is carried out in the presence of a cracking catalyst and in conditions in the reactor (1) suitable to cause the plastics forming said waste to be entirely converted into gas, and in that it further includes a step during which said gas is recovered for producing energy and/or recycled material. The reactor is characterised in that it comprises a so-called spouted bed contact system which makes it possible to separate said metal from the bed without the need to extract the catalyst.

IPC Classes  ?

• C10B 49/10 - Destructive distillation of solid carbonaceous materials by direct heating with heat-carrying agents including the partial combustion of the solid material to be treated with hot gases or vapours, e.g. hot gases obtained by partial combustion of the charge while moving the solid material to be treated in dispersed form according to the "fluidised bed" technique
• C10B 53/07 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form of synthetic polymeric materials, e.g. tyres
• B01J 8/24 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with fluidised particles according to "fluidised-bed" technique
• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
• C22B 21/00 - Obtaining aluminium

Abstract

A method includes the stage of carrying out catalytic pyrolysis of said plastics and is characterised in that said pyrolysis is carried out by means of the spouted-bed contact system and under conditions in the reactor (1) suitable for permitting total conversion of said plastics to gas, and in that it also includes the stage of generating electrical energy by means of cogeneration equipment fed from hydrocarbons. It is self- sufficient in energy terms and has very high energy efficiency.

IPC Classes  ?

• C10B 49/10 - Destructive distillation of solid carbonaceous materials by direct heating with heat-carrying agents including the partial combustion of the solid material to be treated with hot gases or vapours, e.g. hot gases obtained by partial combustion of the charge while moving the solid material to be treated in dispersed form according to the "fluidised bed" technique
• C10B 53/07 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form of synthetic polymeric materials, e.g. tyres
• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless

Abstract

The method includes the stage of carrying out pyrolysis of the rubber and carbon black waste that said tyres contain, and the stage of recovering said carbon black from pyrolysis of the waste, and is characterised in that said pyrolysis is carried out in the presence of a cracking catalyst and under conditions suitable to permit total conversion of the rubber that said waste contains to gas, in reactor conditions (1), and in that it further includes the stage of recovering said gas for use as energy and/or materials. The reactor is characterised in that it includes the so-called spouted bed contact system, which makes it possible to separate said carbon black from the bed without the need to remove the catalyst.

IPC Classes  ?

• C10B 49/10 - Destructive distillation of solid carbonaceous materials by direct heating with heat-carrying agents including the partial combustion of the solid material to be treated with hot gases or vapours, e.g. hot gases obtained by partial combustion of the charge while moving the solid material to be treated in dispersed form according to the "fluidised bed" technique
• C10B 53/07 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form of synthetic polymeric materials, e.g. tyres
• B01J 8/24 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with fluidised particles according to "fluidised-bed" technique
• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
• C09C 1/48 - Carbon black

Abstract

The invention relates to electric line protection for determining the direction in which a fault occurs, which makes use of direct sequence power. For this purpose, a scalar value is calculated on the basis of the pre-fault voltage (V1P), the variation in voltage in respect of that prior to the fault (ﶴV1), the variation in strength in respect of that prior to the fault (ﶴI1,), the direct sequence impedance of the line (ZL1), the maximum phase difference between normal voltages at both ends of the line (ϑ) and the values adjusted by the user (&ggr;, δ), and said value is compared with two pre-set references (KF, KR) also set by the user, in order to determine the direction of the fault. The scalar value is calculated using expression (I). The decision rule for determining the direction of the fault is as follows: if ϰឬKF the fault is in the forward direction and if ϰᡶ KR the fault is in the backward direction.

IPC Classes  ?

• G01R 31/08 - Locating faults in cables, transmission lines, or networks
• H02H 3/08 - Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection responsive to excess current
• H02H 3/38 - Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection responsive to both voltage and currentEmergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection responsive to phase angle between voltage and current
• H02H 7/26 - Sectionalised protection of cable or line systems, e.g. for disconnecting a section on which a short-circuit, earth fault, or arc discharge has occurred