Abstract

The present disclosure is broadly concerned with green crosslinkers for use with reservoir temperatures ranging from about 80° C. to about 130° C. These green crosslinkers can crosslink acrylamide-based polymers with crosslinking times ranging from several hours to weeks. The mixture of this green crosslinker with an acrylamide-based polymer solution can be applied to plug reservoirs with fractures and/or matrix channels. Moreover, it can be used in different permeability reservoirs with various channeling problems.

IPC Classes  ?

• C08F 22/38 - Amides
• C08F 26/10 - N-Vinyl-pyrrolidone
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules

Abstract

Described herein are shape memory elastomers (SMEs) each comprising a copolymer network structure. The network comprises two distinct polymer components: a first polymer that is a biocompatible, biodegradable shape memory polymer exhibiting hydrophobic properties, and a second polymer that is covalently bonded to the first via the covalent or/and noncovalent interactions. This second polymer is distinguished by its biocompatible, biodegradable, and hydrophilic nature, featuring functional groups with hydrogen bonding capabilities. The network can also incorporate a third polymer, resulting in an SME with multiple shape transition properties. The SMEs described herein have unique potential as biomedical implants. Methods of manufacture are also provided.

IPC Classes  ?

• C08L 33/12 - Homopolymers or copolymers of methyl methacrylate

Abstract

The present invention provides methods and compositions for storage and preservation of tissues, for example peripheral nerve allografts, for extended periods of time at room temperature in a sterile tissue culture container or bag.

IPC Classes  ?

• A01N 1/10 - Preservation of living parts
• A01N 1/16 - Physical preservation processes
• A01N 1/12 - Chemical aspects of preservation

Abstract

A method of altering fatty acid and/or triacylglycerol production in plants and/or algae is provided. The method includes altering activity levels of alpha-carboxyltransferase (α-CT), a catalytic subunit of acetyl-CoA carboxylase (ACCase) by modulating an expression of at least one carboxyltransferase interaction (CTI) gene encoding at least one CTI protein.

IPC Classes  ?

• C12N 9/10 - Transferases (2.)
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

Non-human animals and offspring thereof comprising at least one modified chromosomal sequence in a gene encoding a CD163 protein are provided. Animal cells that contain such modified chromosomal sequences are also provided. The animals and cells have increased resistance to pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV). The animals and offspring have chromosomal modifications of a CD163 gene. The invention further relates to methods of breeding to create pathogen-resistant animals and populations of animals made using such methods.

IPC Classes  ?

• A01K 67/0276 - Knock-out vertebrates
• A01K 67/02 - Breeding vertebrates
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 5/075 - OocytesOogonia
• C12N 5/076 - Sperm cellsSpermatogonia
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 9/22 - Ribonucleases
• C12N 15/09 - Recombinant DNA-technology
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/877 - Techniques for producing new mammalian cloned embryos

Abstract

A vehicular adsorbed natural gas (ANG) tank system operates as a mobile, dual gas storage/separation system to enable off-the-natural-gas-grid producers of biogas to use, ship, and process biogas for: (a) onboard delivery to engine of on-demand delivery of methane-rich fuel to an internal-combustion engine; (b) onboard separation of methane from carbon dioxide and extraction of unused fuel as carbon-dioxide-rich commodity, and (c) and large-scale, tractor-trailer shipping of biogas to a biogas upgrading plant and separation of methane from carbon dioxide during discharge at the plant. A mobile tank system on a vehicle comprises vessels filled with porous adsorbent and pressure valves; pressure regulators; pressure/temperature transducers at inlet, outlet, intermediate ports; and an onboard compressor/gas extraction pump. The tank discharging procedure for the separation of biogas into methane and carbon dioxide is such that the concentration of methane in discharged gas is at least 10% greater than in biogas.

IPC Classes  ?

• F17C 5/06 - Methods or apparatus for filling pressure vessels with liquefied, solidified, or compressed gases for filling with compressed gases
• B01D 53/00 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols
• B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes

Goods & Services

Arranging and conducting college athletic events

Goods & Services

(Based on Use) T-shirts; Sweatshirts (Based on Intent to Use) Hats

Abstract

Aspects disclosed herein relate to compositions comprising novel phosphoinositide 3-kinase (PI3K) inhibitors, and methods of making the novel PI3K inhibitors. Further, various aspects relate to one or more methods of treating a disease using the compositions disclosed herein, including targeted delivery of the novel PI3K inhibitors disclosed herein.

IPC Classes  ?

• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• C07D 471/04 - Ortho-condensed systems

Abstract

A negative stiffness shell has a convex first position, but can transition or snap to a concave second position under a force applied to the exterior surface of the shell in the convex first position. During the transition, the shell exhibits negative stiffness that permits a large amount of energy to be absorbed. The negative stiffness shell can withstand a high initial force threshold prior to transitioning. In the second, concave position the shell can still resist force. Moreover, it is possible for the shell to revert back to the first, convex position with minimal plastic deformation for subsequent use. The negative stiffness shells can be used collectively and/or in layers to increase the efficiency of the overall negative stiffness shell unit.

IPC Classes  ?

• F16F 3/087 - Units comprising several springs made of plastics or the like material
• F16F 1/373 - Springs made of plastics, e.g. rubberSprings made of material having high internal friction characterised by having a particular shape

Abstract

Implementations of the invention provide semiconductor devices including radiation-doped semiconductor junctions, and methods of making the same. In one embodiments, a method includes: providing a set of adjacent semiconductor layers comprising a first semiconductor layer adjacent a second semiconductor layer different from the first semiconductor layer; exposing the set of adjacent semiconductor layers to thermal neutron radiation, thereby causing a first stable isotope of the first semiconductor layer to convert to a second stable isotope, resulting in a doped first semiconductor layer; and exposing the set of adjacent semiconductor layers to thermonuclear irradiation to cause a third stable isotope of the second semiconductor layer to react, resulting in a doped second semiconductor layer; wherein the doped first semiconductor layer and the doped second semiconductor layer form a homojunction or a heterojunction.

IPC Classes  ?

• H10D 62/85 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group III-V materials, e.g. GaAs
• H01L 21/261 - Bombardment with wave or particle radiation to produce a nuclear reaction transmuting chemical elements
• H10D 62/60 - Impurity distributions or concentrations
• H10D 62/83 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group IV materials, e.g. B-doped Si or undoped Ge
• H10D 62/834 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group IV materials, e.g. B-doped Si or undoped Ge further characterised by the dopants
• H10D 62/854 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group III-V materials, e.g. GaAs further characterised by the dopants

Goods & Services

Shirts; T-shirts

Abstract

Detonation nanodiamond nanocarrier platforms to transport quaternary oxime antidotes into the central nervous system have been developed. The nanodiamond-based AChE reactivators contain an organophosphorus poisoning antidote (e.g., a 4-hydroximinopyridinium moiety) bound to a biocompatible linker covalently attached to the nanodiamonds. These functionalized nanodiamonds successfully cross the layer of Madin-Darby Canine Kidney (MDCK) cells, the epithelial cell surrogate BBB model, and demonstrate a measurable dose-independent in vitro reactivation capacity towards human AChE inhibited by toxic organophosphorus compounds.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 35/22 - UrineUrinary tract, e.g. kidney or bladderIntraglomerular mesangial cellsRenal mesenchymal cellsAdrenal gland
• A61K 47/02 - Inorganic compounds

Goods & Services

Retail pharmacy services; Retail drug store services; Retail store services featuring medical supplies

Goods & Services

Occupational therapy; Physical therapy; Physical rehabilitation; Health care services in the nature of athletic training; Rehabilitation patient care services

Abstract

A system and method for measuring one or more viscoelastic properties of a material under measurement is disclosed. The system includes an emitter-observer transducer pair separated by the material. A signal processing assembly is operable to (i) apply a plurality of excitation signals to the emitter transducer, wherein each of the excitation signals comprises a continuous-wave sinusoidal waveform, (ii) record a plurality of output signals at the observer transducer, wherein each of the output signals corresponds to one of the excitation signals, (iii) analyze the output signals to measure the sound speed of the material, and (iv) determine the viscoelastic properties of the material under measurement by optimizing the parameters of an infinite echo model. The system provides a non-destructive approach for in-situ measurement of viscoelastic material properties.

IPC Classes  ?

• G01N 11/00 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties
• G01N 29/024 - Analysing fluids by measuring propagation velocity or propagation time of acoustic waves
• G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details
• G01N 29/24 - Probes
• G01N 29/36 - Detecting the response signal
• G01N 29/46 - Processing the detected response signal by spectral analysis, e.g. Fourier analysis

Abstract

Small anti-inflammatory peptide for blocking NF-κB are disclosed herein. The peptides as well as compositions including the peptides can be administered to inhibit cytokine production and/or inhibit pulmonary inflammation in a subject in need. Particularly embodiments include administration to a subject suffering from coronavirus disease 2019 (COVID-19).

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 31/14 - Antivirals for RNA viruses
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

A hybrid (mechanical-capillary-driven) two-phase loop (HTPL) and associated method of use for data centers. The dual-mode HTPL combines a loop thermosiphon (passive mode) and a pumped two-phase loop (active mode). The HTPL will consist of an evaporator (multiple evaporators used for a server rack), a condenser, a pump, and a liquid reservoir. The operation of the HTPL begins with the pumping of a subcooled liquid from the liquid reservoir to the liquid chamber of the evaporator, in which a fraction of the supplied liquid is drawn into the evaporator wick by capillary pumping. Then, the drawn liquid vaporizes in the evaporator wick by the heat input from a heat source (server electronics), and the saturated vapor exits the evaporator and flows through a vapor line to the condenser, where the vapor is condensed and subcooled. Subsequently, the condensate from the condenser flows back to the reservoir.

IPC Classes  ?

• F28D 15/02 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes
• F28D 15/04 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes with tubes having a capillary structure

Abstract

Crosslinking agents, TRI-1, TRI-2, and TRI-3, and/or a collagen crosslinking mixture comprising two or more of TRI-1, TRI-2 and TRI-3, are presented, as are the syntheses thereof. The collagen crosslinking effects of the mixture of TRI-1, TRI-2, and TRI-3 are significantly enhanced over any of the molecules taken individually. The mixture drastically improves collagen biostability, showing enhanced performance compared to commercially available collagen treatments, and acts quickly, requiring no more than 60 seconds to show inhibition of collagenases. The mixture is also nontoxic and has a slight beige color, which is aesthetically ideal for any treatment that may be visible to others. The collagen crosslinker mixture is furthermore shown to be mixable with commercial dental adhesive without compromising the desired properties of the crosslinkers or the adhesive.

IPC Classes  ?

• A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives

Abstract

A fiber optic cable system configured for distributed sensing in a brittle installation medium, the fiber optic cable system comprising a fiber optic cable and a plurality of anchors. The fiber optic cable includes a fiber core, a buffer layer, a strength member, and a jacket. These components are secured together at a number of anchoring locations along the fiber optic cable so that they are bonded together at the anchoring locations and un-bonded from each other between the anchoring locations. The anchors are attached to the fiber optic cable at the anchoring locations and are configured to engage the brittle installation medium to affix the fiber optic cable to the brittle installation medium at the anchoring locations.

IPC Classes  ?

• G01D 5/353 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells influencing the transmission properties of an optical fibre
• G02B 6/44 - Mechanical structures for providing tensile strength and external protection for fibres, e.g. optical transmission cables

Abstract

Herein are presented methods for incorporating a novel bacteriophage, CAM-21, that exhibits lytic activity against pathogenic E. coli, into food, food packaging, films, and quantum dot-based biosensors. The bacteriophage contains no genes associated with toxins, virulence factors, antibiotic resistance, lysogeny, or allergens. Methods are provided for encapsulating the bacteriophage with proteins and/or carbohydrate materials to enhance stability. Various films in which the bacteriophage are incorporated, and which similarly exhibit suppression of pathogenic E. coli, are also provided. Additionally, when conjugated with N-doped graphene quantum dots, CAM-21 enables biosensor development for E. coli detection in food products through altered photoluminescence emission spectra, and methods for making and using such biosensors are provided.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

A structural health monitoring sensor includes a first layer of micromachined planar foil welded to a target structure, the first layer having a cavity and groove formed therein, the groove extending from the first cavity to the exterior of the target structure. The sensor also having second layer of micromachined planar foil welded to the first layer, the second layer having a second cavity corresponding to the first cavity. The sensor also includes dielectric ceramic coating formed within the cavities and grooves to form a film resonator and film waveguide within the target structure. The resulting waveguide forming an opening on the exterior surface of the target structure. The sensor also includes an adapter attached to the exterior surface of the target structure at the waveguide opening and may be wireless.

IPC Classes  ?

• G01K 5/72 - Measuring temperature based on the expansion or contraction of a material the material being a solid constrained so that expansion or contraction causes a deformation of the solid the solid body being formed of compounded strips or plates, e.g. bimetallic strip specially adapted for indicating or recording with electric transmission means for final indication
• G01K 5/66 - Selection of composition of the components of the system
• G01L 1/25 - Measuring force or stress, in general using wave or particle radiation, e.g. X-rays, neutrons
• H01P 7/10 - Dielectric resonators
• H01P 11/00 - Apparatus or processes specially adapted for manufacturing waveguides or resonators, lines, or other devices of the waveguide type

Abstract

The present disclosure is broadly concerned with low toxicity, high-temperature resistant, recrosslinkable, preformed particle gels (HT-RPPGs) for use with reservoir temperatures ranging from about 80°C to about 130°C. These HT-RPPGs include green crosslinkers that can crosslink acrylamide-based polymers with crosslinking times ranging from several hours to days. An additive such as polyvinyl alcohol can be added to the mixture to control swelling ratios for improved thermal stability. The HT-RPPGs can be used to plug reservoirs with fractures and/or matrix channels. Moreover, these HT-RPPGs can be used in different permeability reservoirs with various channeling problems.

IPC Classes  ?

• C08F 220/56 - AcrylamideMethacrylamide
• C08F 226/10 - N-Vinyl-pyrrolidone
• C08F 2/44 - Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
• C08J 3/075 - Macromolecular gels
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules

Abstract

A device for placing a glaucoma drainage tube into the sulcus of an eye is provided herein. The device comprises a needle that comprises a hub and a shaft such that the shaft extends from the hub. The shaft comprises a proximal portion extending from the hub and terminating in a first bend, a medial portion extending from the first bend and terminating at a second bend, and a distal portion originating at the second bend and terminating at a tip. The distal portion has an ultra-thin outer wall and an inner diameter defining a lumen. Also provided is a method for using the same, known as the sulcus tube internal needle technique (STINT).

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery
• A61B 17/34 - TrocarsPuncturing needles
• A61M 27/00 - Drainage appliances for wounds, or the like

Goods & Services

Health care; Hospital services; Medical clinics; Medical services; Medical services, namely, providing primary and specialty health care services to patients; Medical clinic services; Physical therapy; Preparation of prescriptions by pharmacists; Speech therapy; Telemedicine services; Veterinary services; providing information in the field of healthcare

Abstract

An apparatus for assessing real-time concrete curing in-situ using a probe includes a sensor base, contacts, a housing, and a processing element. The sensor base has a bottom surface and a port extending into the bottom surface for releasably receiving the probe. The contacts are located in the port for electrically connecting to the probe. The housing is supported on the sensor base and houses the processing element. The processing element is in communication with the contacts and configured to receive a from the contacts and determine a curing phase of the concrete based on the signal from the contacts.

IPC Classes  ?

• G01N 33/38 - ConcreteLimeMortarGypsumBricksCeramicsGlass
• G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
• G01R 27/14 - Measuring resistance by measuring current or voltage obtained from a reference source

Abstract

The present disclosure is directed to compositions and methods for treating dystrophinopathies. In particular, the present disclosure provides microdystrophins for treating dystrophinopathies by administering compositions encoding microdystrophins.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Marker panels and methods of using the markers in circulating DNA (cirDNA) in maternal blood and/or maternal urine for early detection of fetal growth disorders (FGDs) are disclosed herein. Use of these marker panels will enable accurate prediction of FGDs using a low invasive approach that can be implemented as early as the first gestational trimester.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
• C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes

Abstract

Systems and methods are disclosed including a modular blast probe comprising a reusable housing and a custom insert configured to engage and position a top surface of a respective one of a plurality of blast gauges or sensing elements substantially flush with an outer surface of the reusable housing.

IPC Classes  ?

• G01H 3/12 - AmplitudePower by electric means

Abstract

Provided are compositions and methods related to producing salivary gland progenitor cells organoids from human pluripotent stem cells. The methods involve converting pluripotent stem cells stepwise into surface ectoderm (SE), oral ectoderm (OE), and salivary gland epithelial progenitors (SGEPs). Differentiated salivary gland cells which can include differentiated salivary gland acinar cell (SGACs), salivary gland ductal cells (SGDCs) or a combination thereof can be produced from the SGEPs. Organoids that contain salivary gland cells are also provided. The cells and organoids are useful for therapeutic and drug screening purposes.

IPC Classes  ?

• C12N 5/0789 - Stem cellsMultipotent progenitor cells
• A61K 35/38 - StomachIntestineGoblet cellsOral mucosaSaliva
• C12N 5/073 - Embryonic cells or tissuesFoetal cells or tissues

Abstract

The present disclosure relates to methods for separating lanthanides and methods for producing non carrier added (n.c.a) 177Lu, for use in particular in nuclear medicine, for diagnostic and/or therapeutic purposes.

IPC Classes  ?

• C25C 1/22 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of metals not provided for in groups
• C25C 7/02 - ElectrodesConnections thereof
• C25C 7/06 - Operating or servicing
• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes

Goods & Services

Alumni association services, namely, promoting the interests of an educational institution and its alumni by developing and maintaining relationships between the institution and its alumni and supporting a culture of philanthropy between the institution and its alumni

Goods & Services

Alumni association services, namely, promoting the interests of an educational institution and its alumni by developing and maintaining relationships between the institution and its alumni and supporting a culture of philanthropy between the institution and its alumni

Abstract

A nanohybrid includes or consisting of Ag—Au—AgCl nanoparticles embedded in lignin-containing nanocellulose (LNC). A green method to form the nanohybrid includes mixing gold and silver metallic precursors in solution with LNC. The solution is maintained for a predetermined time period to permit Ag—Au—AgCl nanohybrid formation via reduction of the metallic precursors by the LNC.

IPC Classes  ?

• A01N 59/16 - Heavy metalsCompounds thereof
• A01N 25/10 - Macromolecular compounds
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
• C02F 1/50 - Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment

Goods & Services

Shirts; Pullovers

Goods & Services

Providing courses of instruction at the university level; Providing courses of instruction at the graduate level; Providing courses of instruction at the post-graduate level; Arranging and conducting college athletic events

Abstract

A sensor-enabled pathogen identification, differentiation, and quantification system that integrates into supply chains in an end-to-end fashion and is built on a multi-source, multi-sectoral data environment. The system uses portable sensing platforms that are easily integrated at multiple points along a supply chain and which integrate sample analysis and data processing such that all necessary work can be performed on-site and/or via wireless data transfer.

IPC Classes  ?

• G01N 33/483 - Physical analysis of biological material
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present disclosure is generally directed to an artificial exonic barcode system. The exonic barcodes comprise a nucleotide sequence comprising from 5′ to 3′ a 5′ barcode, an intron, and a 3′ barcode, and the disclosure is further directed to a library of these exonic barcodes. The disclosure also describes a method of generating the exonic barcode library and using the library of exonic barcodes in a method of screening for efficiency of transformation and/or expression of one or more genetic constructs in a subject. Primers and probes were also designed for validation of these exonic barcodes and corresponding methods.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/86 - Viral vectors
• C40B 40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof
• G16B 30/10 - Sequence alignmentHomology search

Abstract

The present invention relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and/or canine degenerative myelopathy (DM).

IPC Classes  ?

• C12N 15/86 - Viral vectors
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Compositions and methods for improving the regeneration of soft tissues as a result of injury or disease are provided. Various compositions are disclosed including a bioactive glass composition derived from calcining a reactant composition. Methods for treating injured or diseased skeletal muscle comprising contacting the injured or diseased skeletal muscle with the bioactive glass composition are also disclosed.

IPC Classes  ?

• A61K 33/42 - PhosphorusCompounds thereof
• A61K 33/00 - Medicinal preparations containing inorganic active ingredients
• A61K 33/08 - OxidesHydroxides
• A61K 33/22 - Boron compounds
• A61K 33/24 - Heavy metalsCompounds thereof
• A61K 33/30 - ZincCompounds thereof
• A61K 33/34 - CopperCompounds thereof
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• C03C 3/19 - Silica-free oxide glass compositions containing phosphorus containing boron
• C03C 4/00 - Compositions for glass with special properties

Abstract

A device for measuring a property of a substrate comprises an enclosure, two resonators, and two probes. The substrate has a top surface, and the enclosure defines a cavity for placing the substrate. The resonators extend into the cavity of the enclosure. The probes extend into the cavity, and each of the probes comprises a loop that extends about an axis that is substantially parallel to the top surface of the substrate so that the probes are operable to excite a transverse magnetic mode signal in the cavity.

IPC Classes  ?

• H01P 7/06 - Cavity resonators
• G01R 27/26 - Measuring inductance or capacitanceMeasuring quality factor, e.g. by using the resonance methodMeasuring loss factorMeasuring dielectric constants
• G01R 31/28 - Testing of electronic circuits, e.g. by signal tracer

Abstract

A method of predicting preferred candidate viral strains for vaccine production is described herein. A machine learning framework for predicting preferred candidate viral strains is provided that emphasizes antigen-matching and yield predictions that correlate with features of viral proteins.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• G16B 35/00 - ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides

Abstract

A computerized warehouse management system and method of use are disclosed that generates a plan for optimizing the order-picking operations for a collaborative human-robot order-picking system. Specifically, the computerized warehouse management system is flexible and scalable to handle any facility layout, swarm of robots, multiple pickers, and logistical/operational constraints. The platform optimizes four key decisions to improve warehouse operations efficiency, including order batching, batch assignment to robots and pickers, batch sequencing, and collaborative human-robot routing.

IPC Classes  ?

• B65G 1/137 - Storage devices mechanical with arrangements or automatic control means for selecting which articles are to be removed
• B65G 61/00 - Use of pick-up or transfer devices or of manipulators for stacking or de-stacking articles not otherwise provided for
• G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders

Abstract

An elastic wave cloaking lattice-based metamaterial for cloaking an object within a void includes a lattice of connected unit cells arranged to form a void, each unit cell comprising a mass and a plurality of connecting springs, the mass coupled by the plurality of connecting springs to masses in adjacent unit cells, the plurality of connecting springs comprising at least two large springs of a first length and at least two short springs of a second length, the first length greater than the second length, the springs and masses having relational and mechanical characteristics to facilitate elastic wave cloaking in the totality of the lattice. The lattice as a whole has metamaterial properties resulting from the positional relationship and mechanical properties of masses and connecting springs of the unit cells such that the lattice at least partially cloaks an object or material portioned within the void from elastic waves.

IPC Classes  ?

• F16F 3/02 - Spring units consisting of several springs, e.g. for obtaining a desired spring characteristic with springs made of steel or of other material having low internal friction
• B33Y 50/00 - Data acquisition or data processing for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing

Abstract

The instant disclosure provides engineered proteins, constructs for expressing the engineered proteins, and methods of using the engineered proteins and constructs for tethering a protein of interest to an RNA molecule.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

A method for synthesizing ultrasmall gelatin nanoparticles. A first desolvation is conducted to produce gelatin strands in a first solution and then setting the pH of the solution to charge and separate the strands. Tripolyphosphate (TPP) is added to the first solution to form gelatin-TPP-gelatin bridges. Second desolvation of the gelatin-TPP-gelatin bridges is conducted in a second solution. The second solution contains an TPP-Ethanol:Acetone mixture in a ratio between 1:1 and 1:5 and TPP between 0.005-0.025 vol % or a Glutaraldehyde-Ethanol:Acetone mixture in a ratio of glutaraldehyde-ethanol:Acetone range of 2.5-12% v/v to produce a colloid of self-assembled gelatin nanoparticles. The method can produce nanomaterial consisting of a plurality of gelatin nanoparticles sized at ˜10 nm. The nanomaterial can encapsulate a drug, metal nanoparticle or contrast agent.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 33/242 - GoldCompounds thereof
• A61K 33/243 - PlatinumCompounds thereof
• A61K 49/04 - X-ray contrast preparations

Abstract

Viscoelastic trauma attenuating backings for use in body armor to reduce non-penetrating shockwave injuries. In particular, a protective armor liner comprising a viscoelastic material and graphene nanoplatelets. Also described is a protective armor comprising a protective armor liner disposed therein or disposed thereon, wherein the protective armor liner comprises a viscoelastic material and graphene nanoplatelets.

IPC Classes  ?

• F41H 5/007 - Reactive armourDynamic armour

Abstract

An in vivo animal retention, data collection and analysis system that comprises an animal retention structure that is structured and operable to temporarily restrain a live animal to be scanned in specific location. The system additionally comprises an animal data acquisition system that is structured and operable to acquire phenotypic data of the animal to be scanned. The system further comprises a data processing system that is structured and operable to execute one or more animal efficiency algorithm that utilizes the acquired phenotypic data to calculate the efficiency of the animal to be scanned.

IPC Classes  ?

• A01K 11/00 - Marking of animals
• A01K 29/00 - Other apparatus for animal husbandry
• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A01K 1/06 - Devices for fastening animals, e.g. halters, toggles, neck-bars or chain fastenings

Abstract

A treatment composition for the suppression of Type 1 Diabetes (T1D) is described herein, as are methods for using the treatment. Interleukin-4 administrated intrathymically promotes improved central tolerance and minimizes the escape of self-reactive T cells. As a result, negative selection of self-reactive T cells is improved and preservation of a diverse T cell repertoire in the periphery is made possible in patients with or susceptible to T1D.

IPC Classes  ?

• A61K 38/20 - Interleukins
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• C07K 14/54 - Interleukins [IL]
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

The present disclosure describes a treatment composition comprising a nanoparticle composition comprising nanoparticles functionalized with surface amine groups and a crosslinking composition comprising genipin. The disclosure also describes a kit comprising the treatment composition, and instructions for using the kit to crosslink the nanoparticles to a tissue graft. The treatment composition and kit can be used to crosslink nanoparticles to a tissue graft, and the resulting tissue graft can be used to replace defective tissue in a subject in need thereof.

IPC Classes  ?

• A61L 27/04 - Metals or alloys
• A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
• A61F 2/10 - Hair or skin implants
• A61F 2/24 - Heart valves
• A61K 9/14 - Particulate form, e.g. powders
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

The disclosure relates to therapeutic methods comprising administering compounds that can inhibit prolyl hydroxylase and pharmaceutical compositions which comprise the prolyl hydroxylase inhibitors. In particular, the methods and pharmaceutical compositions described herein can be useful for treating a disease or condition of copper metabolism in subjects in need thereof, such as a subject having Wilson disease or Menkes disease.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
• A61K 31/30 - Copper compounds
• A61K 31/33 - Heterocyclic compounds

Abstract

A unique open-structured graphene material is provided as well as methods of making and using the same. The open-structured graphene may be formed by carbonization of biomass, such as soybeans, followed by an exfoliation process to provide the graphene particles. Unlike pristine graphene, the open-structured graphene of the present technology has an irregular hierarchical pore structure and one or more layers with an undulating shape, which permits it to better facilitate the intercalation of certain doping particles and provides enhanced flexibility to maintain its structure in various end use application (e.g., batteries).

IPC Classes  ?

• C01B 32/19 - Preparation by exfoliation

Abstract

Improved methods and systems for the electrochemical exfoliation of carbonaceous particles to provide graphene are provided. In some aspects, systems according to the present technology may include a plurality of electrodes that may, for example, have an aspect ratio greater than about 3:1. Additionally, a continuous and optionally closed-loop electrochemical exfoliation system may be used. Embodiments of the present technology can achieve graphene yields well in excess of 50% in a more cost- and operationally efficient manner.

IPC Classes  ?

• C01B 32/19 - Preparation by exfoliation

Abstract

Methods of manufacturing oxalic acid from lignocellulosic biomass and use of the manufactured oxalic acid the acidic activator in a new-concept, acid-base cement (ABC) are disclosed.

IPC Classes  ?

• C12P 7/46 - Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
• C12N 1/14 - Fungi Culture media therefor
• C12N 1/22 - Processes using, or culture media containing, cellulose or hydrolysates thereof
• C04B 28/10 - Lime cements or magnesium oxide cements
• C04B 28/28 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing organic polyacids, e.g. polycarboxylate cements
• C04B 9/04 - Magnesium cements containing sulfates, nitrates, phosphates, or fluorides
• C07C 55/06 - Oxalic acid
• C12F 3/00 - Recovery of by-products
• C04B 111/00 - Function, property or use of the mortars, concrete or artificial stone

Abstract

2244), or mixtufres thereof, and geographically abundant mineral bases, with or without small-dose functional admixtures or additives.

IPC Classes  ?

• C04B 12/00 - Cements not provided for in groups
• C04B 7/153 - Mixtures thereof with other inorganic cementitious materials or other activators
• C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
• C04B 24/06 - Carboxylic acidsSalts, anhydrides or esters thereof containing hydroxy groups
• C04B 24/08 - FatsFatty oilsEster type waxesHigher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl groupOxidised oils or fats
• C04B 103/22 - Set retarders
• C04B 111/10 - Compositions characterised by the absence of a specified material

Abstract

Small, low molecular weight compounds which inhibit the cellular activity of P-type Cu-ATPases, ATP7A and/or ATP7B, and pharmaceutical compositions containing the compounds, are described. Methods of using said compounds in the treatment or prevention of any disease in which copper and/or P1B-type heavy-metal ATPases contribute to disease pathology are also described.

IPC Classes  ?

• A61K 31/265 - Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
• A61K 33/34 - CopperCompounds thereof
• A61K 33/38 - SilverCompounds thereof
• A61P 35/00 - Antineoplastic agents
• C07C 327/40 - Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Abstract

Juglans plant named ‘Hickman’ is characterized by high-yield, abundant spur-bearing, medium nut and kernel size, and high kernel percentage. Taken together, ‘Hickman’ produces a high yield of kernels. The cultivar's nuts have a low to moderate rate of defects, and its kernel has good flavor and color quality. ‘Hickman’ is protogynous, with pistillate bloom beginning mid-season and extending about two-weeks and staminate bloom occurring mid-to-late season.

IPC Classes  ?

• A01H 5/10 - Seeds
• A01H 6/00 - Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy

Abstract

Described herein are luminescent sila- and germafluorenes. Also described herein are methods of making and using sila- and germafluorenes. The position and the type of substituent impact the absorption and emission properties in solution and in the solid-state and subsequently influence the role of sila- and germafluorenes as biosensors.

IPC Classes  ?

• C07F 7/30 - Germanium compounds
• C07D 209/10 - IndolesHydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
• C07D 235/18 - BenzimidazolesHydrogenated benzimidazoles with aryl radicals directly attached in position 2
• C07D 263/57 - Aryl or substituted aryl radicals
• C07D 277/66 - Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
• C07F 7/08 - Compounds having one or more C—Si linkages

Abstract

The disclosure relates to GATA zinc finger and ULTRAPETALA (UTL) genes associated with increased yield of plants. Also disclosed are plants comprising altered expression or activity of the GATA zinc finger or UTL polypeptides along with related methods of increasing yield of plants.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
• A01H 5/10 - Seeds
• A01H 6/54 - Leguminosae or Fabaceae, e.g. soybean, alfalfa or peanut
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants

Abstract

Described herein are compositions and methods for inducing immune tolerance comprising lipocoacervates loaded with a FasL species and IL-2 protein for controlled release of biologically active FasL and IL-2 over an extended time period.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 19/00 - Hybrid peptides
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/20 - Interleukins
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• C07K 14/55 - IL-2
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

Provided herein are real-time, label-free methods, systems, apparatuses, and compositions for the detection and characterization of dynamic aptamer-small molecule interactions through the use of nanopore systems that provide accurate detection of time-resolved dynamic nucleic acid conformational variations in response to small molecule binding. The methods, systems, apparatuses, and compositions can quantify specific ligands, elucidate nucleic acid-ligand interactions, and pinpoint the nucleic acid motifs for ligand binding, showing the potential for small molecule biosensing, drug discovery assayed via RNA and DNA conformation changes, and the design of artificial riboswitch effectors in synthetic biology.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6825 - Nucleic acid detection involving sensors
• C12Q 1/6869 - Methods for sequencing
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention is broadly concerned with mineralization methods that assist in permanent carbon storage. The methods provide a storage mechanism for oxalic acid generated by existing or future-developed carbon capture and conversion methods that convert CO2 to oxalic acid. That oxalic acid can be injected into a subsurface rock formation containing non-carbonate rock to form oxalates or oxalate hydrates. Alternatively, oxalic acid can be mixed with mine tailings, well drilling dirt, crushed rocks, etc., that contain desired non-carbonate rock minerals, to promote mineralization.

IPC Classes  ?

• E21B 43/28 - Dissolving minerals other than hydrocarbons, e.g. by an alkaline or acid leaching agent

Goods & Services

Business networking service; On-line business networking services; Association services, namely, promoting the interests of alumni of a university by means of organizing alumni networking events and providing a website featuring alumni and alumni association information

Abstract

Methods for predicting canine hip dysplasia (CHD) in an immature canine subject are provided. The methods include the use of concentration profiles of a plurality of polypeptides, including C2C, CTX-I, CTX-II, RANKL, PIICP, COMP, PINP. Also provided are CHD biomarker profiles for predicting or diagnosing CHD in immature or young canines before CHD develops. Diagnostic reagents and kits for the same are also provided.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A noise-reducing surgical aspirator that includes a tube, a handle, having a first end portion, a second end portion, and a first internal fluid conduit, where the first end portion of the handle is attached to the tube in fluid communication, and a surgical aspirator tip having a second internal fluid conduit that is in fluid communication with the first internal fluid conduit of the handle and having a first end portion attached to the second end portion of the handle and having a second end portion having an opening, wherein the second internal fluid conduit of the surgical aspirator tip includes a first inner recessed radius and a second radius with a first fillet located between the first inner recessed radius and the second radius and also includes a third outer radius of the opening and a second fillet located between the second radius and the third outer radius.

IPC Classes  ?

• A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems

Abstract

A method of producing a four-layer silicon diode, including selecting a first silicon wafer, wherein said first silicon wafer is CZ-grown B-doped with <100> orientation, a resistivity of less than 0.01 Ohm-cm, and an oxygen content of greater than 10 ppma, and then selecting a second silicon wafer, wherein said second silicon wafer is CZ-grown P-doped with <100> orientation, a resistivity of less than 0.005 Ohm-cm, and an oxygen content of greater than 10 ppma, followed by cleaning the respective first and second silicon wafers. The wafers are then HF treated to yield respective first and second cleaned wafers, the first cleaned wafer is positioned into a first furnace and the second cleaned wafer is positioned into a second furnace, wherein the first and second furnaces are not unitary. Next is annealing the respective first and second cleaned wafers in a reducing atmosphere to yield respective first and second respective out-diffused gradient wafers, followed by bonding together respective first and second heat-treated wafers to yield a mated and/or bonded four-layer substrate having a first heavy doped n-type layer, a second gradient doped n-type layer, a third gradient doped p-type layer, and a fourth heavy doped p-type layer.

IPC Classes  ?

• H01L 29/861 - Diodes
• H01L 29/66 - Types of semiconductor device

Abstract

Genetically modified legume plants comprising a reversibly-sterile phenotype or an improved plant-pollinator phenotype are disclosed. Methods of using the plants to produce hybrid legume seed are also disclosed.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• A01H 1/02 - Methods or apparatus for hybridisationArtificial pollination
• A01H 6/54 - Leguminosae or Fabaceae, e.g. soybean, alfalfa or peanut
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants

Abstract

A sensor for detecting virus, including virus particles and/or genetic sequences, and method of fabrication. The sensor includes a field effect transistor (FET) having source and drain electrodes formed on a substrate and a two-dimensional virus sensing transduction material (VSTM) film formed on the FET. The VSTM film is configured to collect a sample collected from a subject and comprises MXene-graphene. The VSTM film has an antibody corresponding to the virus particles to be detected linked to the film. A drain-source current response of the FET is representative of an amount of the virus particles in the sample for indicating an infection.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Goods & Services

providing facilities for an array of sporting events, sports and athletic competitions and awards programs

Abstract

A variable resistance device includes first and second body elements and a force-generating system disposed therebetween. The force-generating system includes a resiliently deflectable beam extending relative to the first body element and toward the second body element, an interface element, and a cam projecting relative to the second body element and toward the first body element. The cam presents a cam surface. The interface element shifts along the cam surface upon application of a driving force to at least one of the body elements relative to the other and consequent shifting of the body elements relative to each other, resulting in corresponding bending of the beam and consequent generation of a resistance force by the beam. The cam surface presents a profile that varies along a length thereof, such that the resistance force generated by the beam varies irregularly as the interface element moves along the cam surface.

IPC Classes  ?

• A63B 21/00 - Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices
• A63B 21/02 - Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices using resilient force-resisters
• A63B 21/04 - Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices using resilient force-resisters attached to static foundation

Goods & Services

Shirts; T-shirts

Abstract

A diagnostic and therapeutic radiopharmaceutical includes or consisting of a trimeric amino acid structured peptide with a radiolabel. The radiolabel can be [99mTc] [Tc(H2O)3(CO)3]+ or alpha emitting 225Ac. The trimeric amino acid structured peptide can be formed around phosphorus. The trimeric amino acid can be one of a Glycine, Alanine and Arginine amino acids.

IPC Classes  ?

• A61K 51/08 - Peptides, e.g. proteins
• A61B 6/03 - Computed tomography [CT]

Goods & Services

Education and entertainment services, namely, providing teaching, training, tutoring and courses of instruction at the post-secondary level; encouraging university athletic programs by organizing and conducting educational programs and activities for athletes; providing a website featuring information about education and the educational experiences of university students and alumni

Abstract

A storage fluid heater and methods of its use are disclosed for storing, heating, and/or delivering water. The storage fluid heater includes a secondary structure with a pump and heat transfer surface to pump up colder water from the bottom of the tank that has entered via the fluid inlet, heat the water, and release the water at the top of the tank to be withdrawn via the fluid outlet.

IPC Classes  ?

• F24H 1/20 - Water-storage heaters with immersed heating elements, e.g. electric elements or furnace tubes
• F24H 9/00 - FLUID HEATERS, e.g. WATER OR AIR HEATERS, HAVING HEAT-GENERATING MEANS, e.g. HEAT PUMPS, IN GENERAL Details
• F24H 9/20 - Arrangement or mounting of control or safety devices

Abstract

Provided herein is an all-in-one-RNA sequencing assay that simultaneously delivers a qualitative characterization and quantitative measurement of selected RNAs. Also provided are various uses of the assay.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

Novel compounds and polymer aerogels derived from these compounds are provided. The highly porous, monolithic polymer aerogels are extremely robust having high surface areas, large micropore volumes. and high density of nitrogen and oxygen functionalities. Due to these extraordinary properties, the polymer aerogels possess a high carbon dioxide (CO2) sorption capacity and are highly selective towards CO2 versus other gases, such as H2 and N2. As a result, the polymer aerogels can be used to effectively capture or remove CO2 from the air and/or from flue gases.

IPC Classes  ?

• C07D 239/74 - QuinazolinesHydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• C08J 3/075 - Macromolecular gels

Abstract

The present disclosure is generally directed to a bio-ink system that can be used to print cellularized scaffolds for biomedical applications. In certain configurations, the ink has rheological properties suitable for extrusion-based printing techniques and adipose stem cells infused in the ink remain viable seven days after printing. The ink may comprise a mixture of alginate hydrogels, which provide the structural integrity of the printed scaffolds, and gelatin hydrogels, which support the cell proliferation. Borophosphate glass particles are added to the hydrogel mixture where they release Ca-ions that control the viscoelastic properties of the hydrogel before and after printing. Borophosphate glasses described herein promote significantly better ASC viability than previously employed glasses.

IPC Classes  ?

• A61L 27/10 - Ceramics or glasses
• A61L 27/20 - Polysaccharides
• A61L 27/22 - Polypeptides or derivatives thereof
• A61L 27/26 - Mixtures of macromolecular materials
• B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
• B29C 64/314 - Preparation
• B29K 105/00 - Condition, form or state of moulded material
• B29K 509/08 - Glass
• B29L 31/00 - Other particular articles
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 40/10 - Pre-treatment
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• C09D 7/61 - Additives non-macromolecular inorganic
• C09D 105/04 - Alginic acidDerivatives thereof
• C09D 189/04 - Products derived from waste materials, e.g. horn, hoof or hair

Abstract

The present disclosure relates to methods of diagnosing and treating lung cancer using blood-borne analytes, the levels of which relate to the presence, stage and/or drug-resistant status of lung cancer in an individual. Such analytes are useful for indicating the presence, stage and/or drug-resistant status of lung cancer in an individual and to make treatment decisions for lung cancer patients. The present disclosure also discloses methods of treating lung cancer, some aspects of which include sensitizing lung cancer cells to treatment and decreasing resistance of lung cancer cells to treatment. Also disclosed are kits for practicing methods of the disclosure.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

Described herein are pharmaceutical compositions, medicaments and methods for providing effective immunomodulation with chimeric proteins including FasL moieties for selective and long-lasting regulation of the immune response.

IPC Classes  ?

• A61K 38/20 - Interleukins
• A61K 31/35 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/26 - LymphLymph nodesThymusSpleenSplenocytesThymocytes
• A61K 35/39 - PancreasIslets of Langerhans
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/385 - Haptens or antigens, bound to carriers
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

Disclosed are FasL presenting compositions. The compositions may be used to effect immunomodulation in a variety of contexts. The compositions may be used to decrease rates of transplant rejection.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C07K 14/525 - Tumour necrosis factor [TNF]

Abstract

Described herein are methods of treating cancer by administering to a subject a composition comprising ultrasmall silica nanoparticles to enhance one or more of the following immunotherapies: chimeric antigen receptor (CAR) T-cell therapy, immune checkpoint blockade antibody therapy (ICB), immune inhibitor therapy (e.g., myeloid-targeting inhibitors). In some embodiments, the compositions are used in combination with external beam radiotherapy.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 51/08 - Peptides, e.g. proteins
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• A61P 35/00 - Antineoplastic agents
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided.

IPC Classes  ?

• A01K 67/0276 - Knock-out vertebrates
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

An optical fiber sensor system for in situ high-temperature Raman spectroscopy. The system includes an excitation source, a spectrometer, and a Raman probe. The Raman probe comprises at least one optical fiber coupled to the excitation source and to the spectrometer. The at least one optical fiber transmits laser excitation from the excitation source to a sample and collects light scattered by the sample for analysis by the spectrometer. An external lens arrangement positioned at a distal end of the at least one optical fiber of the Raman probe optically couples the at least one optical fiber to the sample and physically separates the at least one optical fiber from the sample during sampling. The spectrometer performs Raman spectroscopy of the sample based on the light collected by the at least one optical fiber.

Abstract

The present invention relates to compounds, compositions, and methods, for treating viral infections. In particular, entry inhibitor compounds are disclosed for treatment of coronavirus infections, including SARS-COV-1 and SARS-COV-2 infections. The compounds bind to the interface of a SARS-COV-2 spike protein receptor binding domain (RBD) and a host cell ACE-2 receptor. The entry inhibitor compounds show antiviral activity, favorable kinetics, and temporally act at the entry of SARS-COV-2 infection. In embodiments, the compounds are used as medicaments for the inhibition of viral replication including SARS-COV-1 and/or SARS-COV-2 replication, for the treatment or prophylaxis of viral infections including SARS-COV-1 and SARS-COV-2 infections, and/or for the treatment or prophylaxis of an illness due to SARS-COV-1 and SARS-COV-2 infections.

IPC Classes  ?

• A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
• A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
• A61K 31/277 - NitrilesIsonitriles having a ring, e.g. verapamil
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4174 - Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present disclosure is generally directed to compositions and methods related to USP15 inhibitors. More particularly, the present disclosure relates to methods of regulating CRL4CRBN-USP15 pathway (previously referred to as the CRL4CRBN-p97 pathway) and glutamine synthetase levels and methods of treating diseases such as cancer via administration of USP15 inhibitors.

IPC Classes  ?

• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

Compositions and methods for efficiently generating and identifying accurate homologous recombination events are disclosed.

IPC Classes  ?

• C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Abstract

The present disclosure is generally directed to gene editing in plant chloroplast and plant mitochondrial double-stranded DNA. Disclosed herein are cytosine base editors tailored for chloroplast and mitochondrial genomes in plants using plant-specific chloroplast and mitochondrial targeting peptides, a TALE, and a DNA deaminase. The systems of the present disclosure include DNA vectors and protocols to use them for gene editing in plants.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C12N 9/22 - Ribonucleases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Abstract

A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing processes parameters for use in producing an engineered tissue having a desired three-dimensional structure.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
• B29C 64/209 - HeadsNozzles
• B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• B29K 33/00 - Use of polymers of unsaturated acids or derivatives thereof, as moulding material
• B29K 105/00 - Condition, form or state of moulded material
• B29L 31/00 - Other particular articles
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/26 - Inoculator or sampler
• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present disclosure addresses the low bioavailability of current eyedrop formulations and difficulty in scale-up preparation of novel eyedrop formulations based on solid drug nanoparticles by providing a scalable and continuous method for producing these solid dmg nanoparticles using a multi-inlet vortex mixer (MIVM). The solid drug nanoparticles are prepared by nanoprecipitation, which is generally as follows: 1) dissolve hydrophobic or amphiphilic drugs in an organic solvent that is mixable with water; 2) add the dmg solution to an aqueous solution with stirring or vortexing, particles will form during the mixing; and 3) remove the organic solvent by evaporation or dialysis.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61P 27/02 - Ophthalmic agents

Abstract

The disclosure relates to α-SNAP genes associated with increased resistance of plants to nematodes, particularly resistance of soybean plants to soybean cyst nematode. Also disclosed are plants comprising reduced expression or activity of the α-SNAP genes along with related methods of increasing resistance of plants to nematodes.

IPC Classes  ?

• A01H 1/04 - Processes of selection
• A01H 6/54 - Leguminosae or Fabaceae, e.g. soybean, alfalfa or peanut
• C12N 15/01 - Preparation of mutants without inserting foreign genetic material thereinScreening processes therefor
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Abstract

Disclosed herein are new peptide inhibitors of beta-lactamase that can improve the efficacy of currently available antibiotics. Methods of using the peptide inhibitors for treating bacterial infections are also disclosed.

IPC Classes  ?

• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/04 - Antibacterial agents

Abstract

Markers associated with increased dicamba tolerance in soybeans are provided herein. Also provided are methods to identify plants having said markers and breeding methods to introduce said markers into other soybean plants, as well as methods for producing soybean plants having increased dicamba tolerance.

IPC Classes  ?

• A01H 1/04 - Processes of selection
• A01H 1/00 - Processes for modifying genotypes
• A01H 5/10 - Seeds
• A01H 6/54 - Leguminosae or Fabaceae, e.g. soybean, alfalfa or peanut

Abstract

A cryopreservation medium including: a first cryoprotective particle or macromolecule: a second cryoprotective particle or macromolecule: and an aqueous liquid, wherein the first cryoprotective particle or macromolecule is hydrophilic and has a spherical shape when dissolved or suspended in the aqueous liquid, and wherein the second cryoprotective particle or macromolecule has an affinity for the first cryoprotective particle or macromolecule and an affinity for the plasma membrane of the cell.

IPC Classes  ?

• A01N 1/02 - Preservation of living parts

Abstract

Compositions and methods for efficiently generating and identifying accurate homologous recombination events are disclosed.

IPC Classes  ?

• C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Abstract

Disclosed are genetically modified swine having a genetic modification in at least one of a Presenilin 1 (PSEN1) gene and an amyloid beta precursor protein (APP) gene and method for creating the genetically modified swine.

IPC Classes  ?

• A01K 67/0276 - Knock-out vertebrates
• C12N 9/22 - Ribonucleases
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The current invention describes a method for developing bioactive borate glass (BBG)-hydrogel constructs based on 3D printing technology for healing of burn wounds and low-tomoderate exuding wounds. The hydrogels serve as a water reservoir and binder for BBG, to provide hydration of the BBG-hydrogel construct and to make the bioink printable, while 3D printing technology enables the layer-by-layer deposition of multiple materials including BG and hydrogels such as alginate, gelatin, GelMa, cellulose, chitosan and other like materials, as well as control of pore geometry to increase the available surface area for wound-dressing contact and more favorable cell-biomaterial interactions.

IPC Classes  ?

• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
• B33Y 80/00 - Products made by additive manufacturing

Abstract

The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.

IPC Classes  ?

• A01N 1/02 - Preservation of living parts

Abstract

A method is provided for using Light-Field Dynamic Homography (DH) to generate a large virtual focal plane from a non-rigid camera array with narrow overlaps between their fields of view (FOV). The method incorporates the 3D geometry of the cameras and employs non-linear least square optimization to dynamically estimate the inter-view homography transformations. Remarkably, only two feature correspondences are required between adjacent views to stitch the images and generate a wide virtual focal plane array, eliminating the need for significant FOV overlaps between the multiple cameras.

IPC Classes  ?

• G06T 3/4038 - Image mosaicing, e.g. composing plane images from plane sub-images
• H04N 23/698 - Control of cameras or camera modules for achieving an enlarged field of view, e.g. panoramic image capture
• H04N 23/80 - Camera processing pipelinesComponents thereof
• H04N 23/90 - Arrangement of cameras or camera modules, e.g. multiple cameras in TV studios or sports stadiums

Abstract

Methods and systems for generating 3D models of surfaces that accurately reconstruct both the global structure of an object and its local features are described. The methods and systems generally operated by fusing point features from the point cloud data with voxel features extracted from voxelization procedures. Furthermore, the methods and systems utilize voxelization at multiple spatial resolutions. The use of point-voxel fusion and multiple spatial resolutions may permit the extraction of both global and local geometric features, increasing the accuracy of 3D modeling of objects.

IPC Classes  ?

• G06T 17/00 - 3D modelling for computer graphics
• G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

Abstract

Provided herein are compositions suitable for treating chemically induced eye damage comprising (a) a nonsteroidal anti-inflammatory drug (NSAID), (b) a histone deacetylase (HDAC) inhibitor and (c) an angiotensin converting enzyme (ACE) inhibitor and, optionally, (d) a water-soluble vitamin. Methods of using provided compositions to treat ocular toxicity and corneal damage following exposure to chemical agents (e.g., mustard gas) are also provided.

IPC Classes  ?

• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61K 31/401 - ProlineDerivatives thereof, e.g. captopril
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]