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1.
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TRYPSIN VARIANTS WITH IMPROVED ENZYMATIC PROPERTIES
| Application Number |
17416975 |
| Status |
Pending |
| Filing Date |
2019-12-19 |
| First Publication Date |
2022-07-28 |
| Owner |
BIOPHARMA TRANSLATIONSINSTITUT DESSAU FORSCHUNGS GMBH (Germany)
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| Inventor |
- Wartner, René
- Boehme, Marcus
- Bordusa, Frank
- Simon, Andreas Hans
- Richter, Thomas
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Abstract
The present invention relates to trypsin variants with improved enzymatic properties, and particularly relates to a mutated trypsin comprising an amino acid substitution at least at two amino acid positions leading to an increased affinity for the nucleophilic substrate and/or at least at two amino acid positions leading to a reduced hydrolysis activity.
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2.
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TRYPSIN VARIANTS WITH IMPROVED ENZYMATIC PROPERTIES
| Application Number |
EP2019086425 |
| Publication Number |
2020/127808 |
| Status |
In Force |
| Filing Date |
2019-12-19 |
| Publication Date |
2020-06-25 |
| Owner |
BIOPHARMA TRANSLATIONSINSTITUT DESSAU FORSCHUNGS GMBH (Germany)
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| Inventor |
- Wartner, René
- Boehme, Marcus
- Bordusa, Frank
- Simon, Andreas Hans
- Richter, Thomas
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Abstract
The present invention relates to trypsin variants with improved enzymatic properties, and particularly relates to a mutated trypsin comprising an amino acid substitution at least at two amino acid positions leading to an increased affinity for the nucleophilic substrate and/or at least at two amino acid positions leading to a reduced hydrolysis activity.
IPC Classes ?
- C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
- C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
- C12N 9/76 - TrypsinChymotrypsin
- C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
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3.
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TRYPSIN MUTANT FOR C- AND N-TERMINAL MODIFICATION OF POLYPEPTIDES
| Application Number |
EP2019080673 |
| Publication Number |
2020/094840 |
| Status |
In Force |
| Filing Date |
2019-11-08 |
| Publication Date |
2020-05-14 |
| Owner |
BIOPHARMA TRANSLATIONSINSTITUT DESSAU FORSCHUNGS GMBH (Germany)
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| Inventor |
- Bordusa, Frank
- Liebscher, Sandra
- Meyer, Christoph
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Abstract
The present invention relates to a mutated trypsin comprising an amino acid substitution both at position K60 and D189, and at least one more amino acid substitution at position Y39 or Y59, having a preferred recognition site TYR-ARG-Xaa-HIS, wherein Xaa is any amino acid.
IPC Classes ?
- C12N 9/76 - TrypsinChymotrypsin
- C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
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4.
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TrypCo
| Application Number |
017981343 |
| Status |
Registered |
| Filing Date |
2018-11-06 |
| Registration Date |
2019-04-12 |
| Owner |
BioPharma Translationsinstitut Dessau Forschungs GmbH (Germany)
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| NICE Classes ? |
- 01 - Chemical and biological materials for industrial, scientific and agricultural use
- 05 - Pharmaceutical, veterinary and sanitary products
- 42 - Scientific, technological and industrial services, research and design
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Goods & Services
Reagents and bioactive compounds for industrial and scientific use. Pharmaceutical preparations for the treatment of human diseases. Biotechnological research and services in relation with enzymatic modification of proteins.
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