The present invention relates to devices for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart, and related methods of using such closure devices for closing the passageway. The method includes introducing a mechanical closure device into an atrium of the heart and transeptally deploying the closure device across the interatrial septum to provide proximation of the septum secundum and septum primum.
A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 17/06 - NeedlesHolders or packages for needles or suture materials
Described are various embodiments of an improved endoprosthesis that includes at least one tubular graft section coupled to additional tubular graft sections which are then coupled to a tubular bifurcated main section. Various embodiments described and shown herein allow for a health care provider to design and select an appropriate AAA implant for AAA presentations other than an infrarenal AAA.
Described are various embodiments of an improved endoprosthesis that includes at least one tubular graft section coupled to additional tubular graft sections which are then coupled to a tubular bifurcated main section. Various embodiments described and shown herein allow for a health care provider to design and select an appropriate AAA implant for AAA presentations other than an infrarenal AAA. The endoprosthesis can also be utilized in other aortic aneurysm.
A dilator (10) for sheathless access to a vessel of a patient, having a distal portion (14) with a maximal outer diameter that extends from a distal end (12) to a guidewire exit port (16) and a proximal portion (18) with a reduced profile that extends from the guidewire exit port to the proximal end (20) and a lumen (22) that extends between the distal end and the guidewire exit port. A first guidewire (42) may be positioned within the vessel and the dilator advanced over the guidewire. A guide catheter may then be advanced over the dilator.
A catheter system and corresponding methods are provided for accessing a blood vessel true lumen from a sub-intimal plane of the vessel. The catheter includes components that are symmetric about the longitudinal axis and allow for reentry without the need to ensure a correct orientation of the cannula.
Described are various embodiments of an improved endoprosthesis that includes a generally tubular graft, a plurality of independent stent hoops connected to the graft and at least one suture. The at least one suture connects one apex of one stent hoop to two apices of another stent hoop to reduce a predetermined distance between distinct stent hoops so that in a released configuration in a body vessel, the stent-graft is curved away from the longitudinal axis to conform to the body vessel and reduce formation of a gap between one end of the stent-graft with an inner surface of the body vessel.
Described are various embodiments of an improved endoprosthesis that includes a generally cylindrical graft portion that extends along a longitudinal axis to define a flow passage and a plurality of stent hoops. The plurality of stent hoops are connected to the graft portion and disposed in a spaced apart relationship along the longitudinal axis. There is at least a first suture disposed along on the outer surface of the main body. The first suture connects at least two of the spaced apart stent hoops together. The first suture also includes unidirectional barbs (or multidirectional barbs) configured to reduce movement of the main body with respect to a direction of blood flow in an artery.
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
Various embodiments for an endovascular device (and variations thereof) that prevents focalized edge (or end) restenosis. In particular, these improvements would mitigate or prevent focalized restenosis at the ends of the device. The designed-in restenotic regions would be circumferentially and axially distributed so that graft patency is not compromised.
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
9.
THIN-FILM COMPOSITE RETRIEVABLE ENDOVASCULAR DEVICES AND METHOD OF USE
Various embodiments for a composite endovascular device (100) (and variations thereof) that include an inner polymer structure (102) and an outer thin-film shape memory structure (106). The inner polymer structure extends from a distal end to a proximal end along a longitudinal axis (L). The outer thin-film shape-memory structure has an inner thin-film surface coupled to the outer surface (102b) of the inner polymer structure from the distal end to the proximal end with a retrieval member (108) at the proximal end to allow for the prosthesis to be retrieved after placement in a body vessel. The inner polymeric structure can be blended with a suitable bio-active agent or the agent can be loaded into the pores. The device can be permanent or temporary by virtue of being retrievable.
A61F 2/01 - Filters implantable into blood vessels
A61F 2/91 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
A61F 2/962 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
10.
BLOOD FILTER WITH SCAFFOLDS CONFIGURED FOR EXTENDED IMPLANTED DURATION BEFORE RETRIEVAL
Various embodiments for a blood filter are described. In particular, the filter is provided with scaffolds in the main body that are spaced at a predetermined distance away from tissues in which the filter is implanted to allow for retrievability beyond the known or recommended duration. Other features are also described and shown to allow for attainment of the extended duration and retrievability.
A drug delivery system consistent with one aspect of the present invention is a balloon catheter having a drug coated balloon and an enlarged portion distal to the drug coated balloon, the enlarged portion having a diameter larger than the diameter of the pleated balloon when wrapped (aka folded) about the inner shaft of the balloon catheter, and a selectively retractable tubular member surrounding at least the pleated and wrapped balloon and having a distal end located in circumferential contact with the enlarged portion distal to the drug coated balloon to inhibit blood flow proximally into the distal end of the selectively retractable tubular member.
A large lumen guide catheter (10) has an elongate tubular body (22), which has an outer surface (24), an inner surface (44), and a braided wire layer between the inner surface and the outer surface, wherein the wires winding a first helical direction are thicker and wider than the wire winding in a second helical direction opposite the first helical direction.
A61M 25/06 - Body-piercing guide needles or the like
B29C 70/22 - Fibrous reinforcements only characterised by the structure of fibrous reinforcements using fibres of substantial or continuous length oriented in at least two directions forming a two dimensional structure
A device and method for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The deployment device has a first tubular structure having proximal and distal ends. A second tubular structure is substantially coaxial to and slideably engaged within the first tubular structure. The second tubular structure has a first substantially linear shape when constrained within the first tubular structure, and a second curvilinear shape when telescopically extended from the distal end of the first tubular structure. A third tubular structure is substantially coaxial to and slideably engaged within the second tubular structure. The third tubular structure is configured to provide sufficient rigidity to push the mechanical closure device from the distal end of the second tubular structure, and provide sufficient flexibility to assume a curvilinear shape when deflected by the second tubular structure.
Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61K 31/08 - Ethers or acetals acyclic, e.g. paraformaldehyde
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A composition of a polyamide and PTFE produces a lubricious surface on extruded medical tubing. The small size of the PTFE powder when compounded with polyamide disperses uniformly and produces an intrinsically lubricious polymer. Such a composition can be useful in medical, intralumenal tubing.
Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.
Described are method and device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart, and related methods of using such closure devices for closing the passageway. The method includes locating a distal end of a closure device adjacent to the passageway. The closure device may include a closure line with proximal and distal ends, an expandable tissue anchor located along the distal end of the closure line, and an expandable occluder member located along the proximal end of the closure line. The expandable tissue anchor is deployed into tissue adjacent to the passageway. The expandable occluder member is deployed adjacent to the passageway such that the expandable occluder member substantially covers the second opening to the passageway.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
18.
Coating for a medical device having an anti-thrombotic conjugate
An implantable device having a coating comprising a comb-type anti-thrombotic conjugate to prevent or reduce the formation of thrombosis on the surface of the device. The device includes a frame expandable from a first diameter to a second diameter wherein the frame has an inner surface and an outer surface, a plurality of structural features disposed along the frame and a plurality of polymer anti-thrombotic conjugate particles situated with the plurality of structural features. The particle can be created utilizing the comb type polymer and heparin conjugate as a carrier for a therapeutic agent within its polymer matrix. The structural features allow for particles having differing properties to be placed at various locations along the device. Moreover, particles having at least two different agents can be located within the same structural feature.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/91 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
19.
Bioabsorbable device having composite structure for accelerating degradation
A medical device has a structure made of a first biodegradable and/or bioabsorbable material and a second biodegradable and/or bioabsorbable material encapsulating a degradation additive incorporated into the first biodegradable and/or bioabsorbable material. The second biodegradable and/or bioabsorbable material has a degradation rate that is faster than the degradation rate of the first biodegradable and/or bioabsorbable material such that the structure experiences a period of accelerated degradation upon release of the degradation additive following sufficient degradation of the second biodegradable and/or bioabsorbable material.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
Novel semi-crystalline, epsilon-caprolactone-rich block copolymers of epsilon-caprolactone and p-dioxanone for long term absorbable medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices. Also disclosed are compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease.
A loading device for self-expanding stents that utilizes a rod with a stop on one end, a compressible sleeve that is slidably mounted on the rod and a compressible member slidably mounted on the rod and configured to increase the diameter of the compressible sleeve when forced against it.
A stent graft device for implanting in a body lumen, comprising a stent with non-staggered or staggered apexes, said stent comprising a plurality of stent sections, bendable connecting members forming said non-staggered or staggered apexes and connecting each of said stent sections to other stent sections to form a zigzag pattern, wherein said stent is staggerdly sutured to a graft by a plurality of suture knots, and wherein said suture knots and staggered apexes are staggered when said stent sections are crimped, and methods of use thereof.
This disclosure is directed to systems and methods for providing a guiding device having a dilatable, drilling tip. The tip is formed by wound helical members such that resistance to rotation in an unwinding direction dilates the tip. The helical members are configured so that the dilatable tip increases in stiffness when the helical members are tensioned by a resistance to rotation in the winding direction. In some embodiments, application of relative force between coaxial inner and outer tubular members is used to control the dilation, stiffness and drilling of the guiding member.
This disclosure is directed to systems and methods for re-entering the true lumen of a vessel. The re-entry catheters (10) employ deflectable struts (20) to stabilize and support the distal tip (16) in a subintimal location while a passageway back into the true lumen is formed. Re-entry to the true lumen can be effected with a cutting element or with a conventional guidewire.
This disclosure is directed to systems and methods for holding a medical device such as a drug-eluting stent (100) undergoing dissolution analysis. A clip (210) retains the device in a specific, reproducible orientation and positions it within a sample cell (202) of the dissolution testing apparatus. The sample cell is a flow-through cell having an inlet (204) and an outlet (206). Preferably, the medical device is positioned away from areas having relatively greater flow turbulence.
Tubing made of two or more polymers circumferentially arranged around the perimeter of the tubing in a single layer may be useful as medical tubing. Specifically, such tubing may be useful in catheters, sheaths, sheath introducers, implant delivery systems, and other medical devices having elongated tubular components. Selection of the two or more polymers based on the durometer and melting temperature permits optimization of axial strength and flexibility for particular applications. Such tubing may be extruded as a single layer tubing or a multi-layer tubing where the additional layers may be single material layers or more multi-polymer layers.
Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
The present invention includes biocompatible polymeric coatings, membranes, matrices, and films to be used with implantable medical devices. Medical devices containing such materials applied to a surface thereof contain a film-forming fluorous homo-polymer or copolymer containing the polymerized residue of a fluorous moiety, wherein the relative amounts of the polymerized residues of one or more moieties are effective to provide the coating and films with properties effective for use in coating implantable med devices.
In accordance with the present invention, a high intensity radiopaque contrast agent is disclosed. The agent may be coated on or incorporated within bulk materials, which may then be subsequently utilized to fabricate a radiopaque medical device. Primary effects through chemistry include higher radiopaque concentrations per unit weight of the radiopaque element or agent. Secondary effects include selective placement of the radiopaque elements which may further enhance the radiopacity of the device with reduced requirements of the radiopaque agent. Such a radiopaque contrast agent may be produced in various forms such as a dendrimer and/or incorporated as the end groups of polymeric chain. In addition one can incorporate biological and/or pharmaceutical agents in combination with the present invention.
The present invention relates to devices for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart, and related methods of using such closure devices for closing the passageway. The method includes introducing a mechanical closure device into an atrium of the heart and transeptally deploying the closure device across the interatrial septum to provide proximation of the septum secundum and septum primum.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
A61B 17/06 - NeedlesHolders or packages for needles or suture materials
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A plurality of endoluminal segments axially connected by fiber bridges is disclosed. The endoluminal segments may be superelastic nitinol that is balloon-expandable or self-expanding. The intraluminal segments may possess a textured surface or at least one geometric feature per segment, located at the apex of a strut pair comprising the intraluminal segment, serving as an anchoring point for the fiber bridges. These geometric features may transmit axially compressive loads during deployment from a device such as a catheter, and may be capable of interlocking the endoluminal segments when constrained within a device such as a catheter. The fibers comprising the bridges may be polymeric, silk, collagen, bioabsorbable, or a blend thereof. The fiber network comprising the bridges may be regularly oriented, randomly oriented, localized, or continuous. The intraluminal segments and fiber bridges may be individually impregnated with therapeutic material, or may both be impregnated with therapeutic material.
A stent or other implantable medical device for the local delivery of a selective adenosine receptor agonist may be utilized to reduce myocardial injury following an acute myocardial infarction. As soon as possible following an acute myocardial infarction a stent or other suitable device comprising and capable of delivering a selective adenosine receptor agonist is positioned in the blood vessel with the occlusion responsible for causing the infarct. Once in position, the stent or other intraluminal device is deployed to remove the occlusion and reestablish blood flow to the specific area, region or tissue volume of the heart. Over a given period of time the selective adenosine receptor agonist elutes from the stent or other device into the downstream coronary blood flow into the hypoxic cardiac tissue for a time sufficient to reduce the level of myocardial injury.
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61K 31/7076 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A stent or other implantable medical device for the local delivery of a selective adenosine receptor agonist may be utilized in combination with other therapeutic agents to reduce myocardial injury following an acute myocardial infarction. As soon as possible following an acute myocardial infarction a stent or other suitable device comprising and capable of delivering a selective adenosine receptor agonist is positioned in the blood vessel with the occlusion responsible for causing the infarct. Once in position, the stent or other intraluminal device is deployed to remove the occlusion and reestablish blood flow to the specific area, region or tissue volume of the heart. Over a given period of time the selective adenosine receptor agonist alone or in combination with other therapeutic agents elute from the stent or other device into the downstream coronary blood flow into the hypoxic cardiac tissue for a time sufficient to reduce the level of myocardial injury.
Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions from a stent (100) having reservoirs (106) so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue. Features may be incorporated into the walls and bases of these reservoirs to improve securement of the drug construct.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
36.
METHOD OF MANUFACTURING A POLYMERIC STENT HAVING REDUCED RECOIL
Methods of manufacturing polymeric intraluminal stents, and stents made by such methods, are disclosed. The methods provide for manufacturing polymeric intraluminal stents by inducing molecular orientation in the stents by radial compression thereby providing stents with low recoil post-deployment.
An endoprosthetic device for treating abdominal aortic aneurysms using suprarenal fixation. A stent ring is anchored in an area above the renal arties using self-flaring barbs that project during the nitinol expansion process. Sutures extend from the stent ring to an area below the renal arties to a bifurcated trunk portion comprising a nitinol fabric on a non-kinking frame. The bifurcated trunk is sealed proximal the iliac arteries and includes iliac leg holders having self-flaring retention struts for non-traumatic holding of iliac leg prosthetics. Suprarenal fixation and collapsible cells having retention projections and barbs that only flare during the nitinol expansion process assist in lowering the devices profile and sheathability for percutaneous delivery and may provide for recapturing the anchored device.
The present invention relates to tubular stents that are implanted within a body lumen. The stent (1500) has a cylindrical shape defining a longitudinal axis and includes a proximal helical section (1506), a distal helical section (1507) and an intermediate ring section (1520) there between. Each of the proximal and distal helical sections has of a plurality of longitudinally oriented strut members (1513) and a plurality of circumferentially oriented hinge members (1154) connecting circumferentially adjacent strut members to form a band, the band being wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings, wherein the distal helical section is wound about the longitudinal axis in the opposite direction from the proximal helical section. The intermediate ring section includes a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form an endless ring.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
40.
FLEXIBLE HELICAL STENT HAVING INTERMEDIATE STRUCTURAL FEATURE
The present invention relates to tubular stent and drug delivery systems. The stent (1100) has a cylindrical shape defining a longitudinal axis and includes helical section (1108) having of a plurality of longitudinally oriented strut members (1113) and a plurality of circumferentially oriented hinge members (1114) connecting circumferentially adjacent strut members to form a band. The band is wrapped about the longitudinal axis in a substantially helical manner form a plurality of helical windings. The helical section further includes a proximal section (1108a), a distal section (1108b) and an intermediate section (1120), wherein the band forming the proximal and distal sections has members with a first width at coincident points along the band length, and the band forming the intermediate section has members with a second width greater than the first width at coincident points along the band length. The wider width in the intermediate section functionally separates the helical section into two subsections.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
41.
FLEXIBLE HELICAL STENT HAVING INTERMEDIATE STRUCTURAL FEATURE
The present invention relates to tubular stents that are implanted within a body lumen to support the organ, maintain patency and/or deliver drugs or agents. The stent (1200) has a cylindrical shape defining a longitudinal axis and includes a helical section (1208) having of a plurality of longitudinally oriented strut members (1213) and a plurality of circumferentially oriented hinge members (1214) connecting circumferentially adjacent strut members to form a band. The band is wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings. The helical section further includes a proximal section (1208A), a distal section (1208B) and an intermediate section (1220) there between. The stent further includes a plurality of connector members (1212) extending between longitudinally adjacent helical windings, wherein the number of circumferentially adjacent connector members per winding in the intermediate section is greater than the number of circumferentially adjacent connector members per winding in the proximal or distal sections.
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
42.
FLEXIBLE HELICAL STENT HAVING INTERMEDIATED NON-HELICAL REGION
The present invention relates to tubular stents that are implanted within a body lumen. The stent (1400) has a cylindrical shape defining a longitudinal axis and includes a helical section (1408) and a closed endless ring section (1420) within the helical section. The helical section has of a plurality of longitudinally oriented strut members (1413) and a plurality of circumferentially oriented hinge members (1414) connecting circumferentially adjacent strut members to form a band, the band being wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings. The closed ring section interrupts the repeating helical pattern and separates the helical section into a proximal helical section and a distal helical section. The intermediate ring section includes a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form an endless ring.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
The present invention relates to tissue - supporting medical devices and drug delivery systems, and more particularly to tubular flexible stents that are implanted within a body lumen of a living animal or human to support the organ, maintain patency and/or deliver drugs or agents. The tubular flexible stent has a cylindrical shape defining a longitudinal axis and includes a helical section having of a plurality of longitudinally oriented strut members (113) and a plurality of circumferentially oriented hinge members (114c) connecting circumferentially adjacent strut members to form a band. The band is wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings. At least one connector member extends between adjacent windings.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
44.
APPARATUS FOR AND METHOD OF PULLING A TENSILE MEMBER FROM A MEDICAL DEVICE
Mechanisms for pulling a tensile member (24) a predetermined distance from a medical device (10) having an intracorporeal end and an extracorporeal end are disclosed. Such mechanisms may be safely operated using a robot, two hands, or in some embodiments, only one hand. Such mechanisms may include one or more cams, drums, or pulley- like members (34) and a lever (48), and may be physically coupled to an extracorporeal portion of the medical device.
The present invention is related to a medical device carrying at least on a portion of its surface a Limus drug or Limus drug preparation and butylated hydroxytoluene at a ratio of 3-100% by weight of butylated hydroxytoluene in relation to 100 % by weight of the Limus drug.
Coatings are provided in which surfaces may be activated by covalently bonding a combination of silane derivatives (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone polymer. Biologically active agents or therapeutic compounds may be deposited with any of the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
C09D 167/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
C09D 4/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond
47.
INTRALUMINAL DEVICE WITH IMPROVED FLEXIBILITY AND DURABILITY
The stent (150) of the present invention is a tubular member having front and back open ends and a longitudinal axis extending there between. The tubular member has a first smaller diameter for insertion into a patient and navigation through the vessels, and a second larger diameter for deployment into the target area of a vessel. The tubular member is made from a plurality of adjacent hoops (152 (a), 152 (b), 152 (c), 152 (d) extending between the front and back ends. The hoops include a plurality of longitudinal struts (160) and a plurality of loops (162) connecting adjacent struts. The stent further includes a plurality of bridges (170) having loop to bridge connections which connect adjacent hoops to one another. The ratio of total number of circumferentially aligned loops to the number of loops spanned by a particular bridge is a whole number.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A61F 2/84 - Instruments specially adapted for their placement or removal
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
48.
Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same
The present invention relates to a drug-containing polymeric composition comprising at least one therapeutic agent encapsulated in at least one biocompatible polymer, wherein at least a portion of the therapeutic agent in this polymeric composition is crystalline. The at least one biocompatible polymer may form a substantially continuous polymeric matrix with the at least one therapeutic agent encapsulated therein. Alternatively, the at least one biocompatible polymer may form polymeric particles with the at least one therapeutic agent encapsulated therein.
A device and method for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The single disc mechanical closure device is comprise of a distal and proximal anchor constrained by a closure line to facilitate mechanical closure by bringing the distal and proximal anchors into close proximity along the closure line.
Medical devices having bonded joints are disclosed. The bonded joints include two surfaces bonded by a layer of phenoxy resin therebetween. In the preferred embodiments, bonded surfaces include materials that are suitable for medical devices. Most preferably, Nitinol includes at least one bonded surface, however, other preferred materials may include, but are not limited to cobalt chromium, stainless steel, titanium, tantalum, and plastic. An intraluminal device including a plurality of locations with a phenoxy resin layer is also disclosed wherein the phenoxy resin further includes a radioopaque additive, a lubricious additive, or both radioopaque and lubricious additives. Also disclosed is an intraluminal device having contiguous heterogeneous structural elements of metallic members and non-metallic sections that are bonded together by a layer of phenoxy resin therebetween.
B32B 9/04 - Layered products essentially comprising a particular substance not covered by groups comprising such substance as the main or only constituent of a layer, next to another layer of a specific substance
B32B 15/04 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance
B32B 15/00 - Layered products essentially comprising metal
B32B 9/00 - Layered products essentially comprising a particular substance not covered by groups
51.
Twisted anchoring barb for stent of abdominal aortic aneurysm (AAA) device
A stent is provided for an endoprosthesis having a main body portion and two leg portions, particularly suitable for treatment of an abdominal aortic aneurism. The stent includes barbs that are twisted and shaped set to point radially outward. Each barb, as formed, points substantially perpendicular relative to the longitudinal axis of the stent, even when in a non-deployed configuration. The motion to move the barb into a deployed configuration for gripping tissue is a twisting motion which moves the barb from being substantially aligned with the circumference of the stent to extending radially outwards from the stent.
This invention relates to devices for navigating passageways in a body, and in particular, to a steerable catheter that can be used to navigate the tortuous anatomy of a body's vasculature. In one embodiment of the invention the deflectable catheter comprises an inner catheter body having a first strut spine member and a cantilevered second strut tang member. An outer catheter body is cooperatively associated with the second strut tang member and an actuator is cooperatively associated with the first strut spine member. The actuator is slideably engaged within the outer catheter body.
A stent is provided for an endoprosthesis having a main body portion and two leg portions, particularly suitable for treatment of an abdominal aortic aneurism. The stent includes barbs that are twisted and shaped set to point radially outward. Each barb, as formed, points substantially perpendicular relative to the longitudinal axis of the stent, even when in a non-deployed configuration. The motion to move the barb into a deployed configuration for gripping tissue is a twisting motion which moves the barb from being substantially aligned with the circumference of the stent to extending radially outwards from the stent.
A stent is provided for an endoprosthesis having a main body portion and two leg portions, particularly suitable for treatment of an abdominal aortic aneurism. The stent includes barbs that are twisted and shaped set to point radially outward. Each barb, as formed, points substantially perpendicular relative to the longitudinal axis of the stent, even when in a non-deployed configuration. The motion to move the barb into a deployed configuration for gripping tissue is a twisting motion which moves the barb from being substantially aligned with the circumference of the stent to extending radially outwards from the stent.
An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
B05D 3/00 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
B05D 1/32 - Processes for applying liquids or other fluent materials using means for protecting parts of a surface not to be coated, e.g. using stencils, resists
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/91 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
The present invention relates to tissue-supporting medical devices and drug delivery systems, and more particularly to tubular flexible stents that are implanted within a body lumen of a living animal or human to support the organ, maintain patency and/or deliver drugs or agents. The tubular flexible stent has a cylindrical shape defining a longitudinal axis and includes a helical section having of a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form a band. The band is wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings. At least one connector member extends between longitudinally adjacent helical windings of the band.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A deflecting guide catheter for use in minimally invasive medical procedures such as the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The catheter includes an elongated tubular portion having various durometers along its length and at least one puller wire attached to an anchor band near the distal end. The deflecting guide catheter is used to provide a means for guiding a plication device or other medical instrument into a desired position within the vasculature or heart chambers of a patient.
The stent of the present invention combines a helical strut band interconnected by coil elements. This structure provides a combination of attributes that are desirable in a stent, such as, for example, substantial flexibility, stability in supporting a vessel lumen, cell size and radial strength. The structure of the stent of the present invention provides a predetermined geometric relationship between the helical strut band and interconnected coil.
A61F 2/91 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
A61F 2/962 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
60.
PLICATION DEVICE WITH FORMABLE LINEAR FASTENER FOR USE IN THE DIRECT PLICATION ANNULOPLASTY TREATMENT OF MITRAL VALVE REGURGITATION
A system for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular tissue each fixed by a retaining clip is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a prolapsable crossing catheter. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. The plication device is then used to make placations in the subvalvular region of the mitral valve annulus. Fourth, a formable linear retainer clip is deployed by the plication device in order to retain the plicated tissue in the plicated form. The formable linear retainer is formed into a reverse "C" clip by the jaws of the plication device acting in conjunction with a retainer pusher.
A61B 17/122 - Clamps or clips, e.g. for the umbilical cord
A61B 17/128 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips
A61B 17/00 - Surgical instruments, devices or methods
61.
MEDICAL DEVICE HAVING BONDING REGIONS AND METHOD OF MAKING THE SAME
Medical devices comprised of bonded joints are disclosed. The bonded joints comprise two surfaces bonded by a layer of phenoxy resin therebetween. In the preferred embodiments, bonded surfaces are comprised of materials that are suitable for medical devices. Most preferably, Nitinol comprises at least one bonded surface, however, other preferred materials may include, but are not limited to cobalt chromium, stainless steel, titanium, tantalum, and plastic. An intraluminal device comprised of a plurality of locations with a phenoxy resin layer is also disclosed wherein the phenoxy resin is further comprised of a radioopaque additive, a lubricious additive, or both radioopaque and lubricious additives. Also disclosed is an intraluminal device comprised of contiguous heterogeneous structural elements comprised of metallic members and non- metallic sections that are bonded together by a layer of phenoxy resin therebetween.
C09J 5/02 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving pretreatment of the surfaces to be joined
C09J 5/06 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving heating of the applied adhesive
The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment.
A biocompatible material may be configured into any number of implantable medical devices including a vascular closure device. The vascular closure device includes a fibrous structure formed from at least one randomly oriented fiber, the randomly oriented fiber comprising at least one polymer, and at least one agent, in therapeutic dosage, incorporated into at least one of the fibrous structure and the at least one randomly oriented fiber.
A method of making a biocompatible, implantable medical device, including a vascular closure device is disclosed. The method includes forming a biocompatible polymer into at least one fiber and randomly orienting the at least one fiber into a fibrous structure having at least one interstitial spaces. Polymeric materials may be utilized to fabricate any of these devices. The polymeric materials may include additives such as drugs or other bioactive agents as well as antibacterial agents. In such instances, at least one agent, in therapeutic dosage, is incorporated into at least one of the fibrous structure and the at least one fiber.
In accordance with the present invention, there is provided a stent for insertion into a vessel of a patient. The stent has a front and back open ends and a longitudinal axis extending therebetween. The stent has a plurality of adjacent hoops that are held in alignment with the longitudinal axis between the front and back open ends by a thin film tube. The hoops are attached to either the inner or outer surface of the thin film tube. The stent is compressed into a first smaller diameter for insertion into the vessel with a delivery tube and a second larger diameter for deployment into the vessel. The inventive stent can be retracted into the delivery tube if it is improperly deployed.
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
B23P 13/04 - Making metal objects by operations essentially involving machining but not covered by a single other subclass involving slicing of profiled material
A medical sheet has an intricate pattern of loops, struts and bridges and is made of a super elastic alloy. The medical sheet includes a plurality of amorphic circles which provide rounded surfaces attached to the outer edges which made the medical sheet a-traumatic when implanted. When the medical sheet is cooled the molecular phase becomes martensitic which allows the medical sheet to be compressed for easier insertion into a patient. When the medical sheet is heated, the molecular phase changes to austenitic which causes the medical sheet to expand to a size suitable for implantation. The medical sheet can be secured within the patient by suturing through holes in the amorphic circles.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A system and method for the treatment of mitral valve regurgitation by- reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device (400) into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a 'C' shaped retainer (500) with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.
A system for using a helical retainer in the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular tissue each fixed by a retaining clip is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a preferably prolapsable crossing catheter (200). Second, a deflecting guide catheter (300) is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device (400) is then used to make plications in at or near the subvalvular region of the mitral valve annulus. Fourth, a helical retainer clip (500) deployed by the plication device in order to retain the plicated tissue in the plicated form. Alternatively, the fourth device is a retainer delivery catheter (600) that enables delivery of a helical retainer over the outside of the plication device.
A system for using a barbed tubular retainer (500) in the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular tissue each fixed by a retaining clip is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter (200). Second, a deflecting guide catheter (300) is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make placations in the subvalvular region of the mitral valve annulus. Fourth, a barbed tubular retainer deployed by the plication device in order to retain the plicated tissue in the plicated form. Alternatively, the fourth device is a retainer delivery catheter (600) that enables delivery of a barbed tubular retainer that is attached to its distal end over the outside of the plication device.
A flexible cannula of medical device conduit (1300) includes an elongated framework (1302) formed from a flexible material (e.g., Nitinol) with a body portion, sharp head (1310), distal end ans proximal end. The flexible medical device conduit also includes a flexible tube (1314) at least partially jacketing the elongated framework between the distal end and the proximal end. Moreover, the sharp head is disposed at the distal end and is configured for subcutaneous skin insertion and the elongated framework and flexible tube define at least one conduit (1315) between the elongated framework and the flexible tube, the conduit having an opening at the distal end.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A tissue repair matrix has an intricate pattern of loops, struts and bridges and is made of a super elastic alloy. The repair matrix includes hooks which improve the ingrowth when implanted and amorphic circles which provide rounded surfaces to the outer edges which made the repair matrix a-traumatic when implanted. When the repair matrix is cooled the molecular phase becomes martensitic which allows the tissue repair matrix to be compressed for easier insertion into a patient. When the tissue repair matrix is heated, the molecular phase changes to austenitic which causes the tissue repair matrix to expand to a size suitable for medical procedure.
A balloon catheter or stent delivery system for medical treatment of a patient has a proximal hub, a balloon, and an improved shaft design The catheter shaft has a rapid-exchange configuration, and a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near a proximal leg of the balloon An inner tubular body defines a guidewire lumen extending from a distal guidewire port at the catheter distal end to a proximal port located at a position between the balloon and the hub The hypotube has an aperture for accepting the inner body proximal end, and a circumferential cut pattern The cut pattern adds flexibility, and may extend from the hypotube distal end to a position proximal of the proximal guidewire port
Coatings are provided in which surfaces may be activated by covalently bonding a combination ofsilane derivatives (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone polymer. Biologically active agents or therapeutic compounds may be deposited with any of the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
This application relates to devices for navigating passageways in a body, and in particular, to a steerable catheter (630) that can be used to navigate the tortuous anatomy of a body's vasculature. In one embodiment of the invention the deflectable catheter comprises an inner catheter body (611) having a first strut spine member (615) and a cantilevered second strut tang member (614). An outer catheter body (607) is cooperatively associated with the second strut tang member and an actuator (606) is cooperatively associated with the first strut spine member. The actuator is slideably engaged within the outer catheter body.
A device and method for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The single disc mechanical closure device is comprise of a distal and proximal anchor constrained by a closure line to facilitate mechanical closure by bringing the distal and proximal anchors into close proximity along the closure line.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
78.
Method of forming a tubular membrane on a structural frame
The present invention relates to a medical device and method of forming the medical device. In particular, the present invention relates to a medical device having a tubular membrane structure over a radially expandable structural frame, and to a method of forming the tubular membrane on the radially expandable structural frame. In one aspect, a structural frame is placed over a spinning mandrel and a fiber is electro-statically spun over at least a portion of the structural frame forming a membrane. A transfer sheath may be used between the mandrel and structural frame to prevent the electro-statically spun fiber from adhering to the mandrel. In another aspect, a first membrane is spun over the mandrel before the structural frame is placed over the mandrel. In this aspect, at least a portion of the structural frame is sandwiched between the membranes. The membrane or membranes and structural frame form a fiber spun frame assembly. The fiber spun frame assembly may be coated with an elastic polymer. In addition, the membrane or membranes may go through some post processing to achieve desired characteristics or configurations.
B29C 41/30 - Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped articleApparatus therefor for making articles of indefinite length incorporating preformed parts or layers, e.g. moulding around inserts or for coating articles
D06M 10/00 - Physical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents or magnetic fieldsPhysical treatment combined with treatment with chemical compounds or elements
H05B 6/00 - Heating by electric, magnetic or electromagnetic fields
79.
SINGLE DISC INTRALUMINAL PATENT FORAMEN OVALE CLOSURE DEVICE
A device and method for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The single disc mechanical closure device is comprise of a distal and proximal anchor constrained by a closure line to facilitate mechanical closure by bringing the distal and proximal anchors into close proximity along the closure line.
The present invention is a method and device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart, and related methods of using such closure devices for closing the passageway.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
81.
BALOON EXPANDABLE BIOABSORBABLE DRUG ELUTING STENT
A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stent (1000) has a plurality of hoop components (1002) interconnected by a plurality of flexible connectors (1004). The hoop components are formed as a continuous series of substantially longitudinally or axially oriented radial strut members (1006) and alternating substantially circumferentially oriented radial arc members (1008). The geometry of the struts and arcs is such that when the stent is expanded, it has very high strains within a relatively small region (1020). This strain localization results in what is often referred to as 'hinging', where the hinge is the small region within which the strains are very high.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
82.
BALLOON EXPANDABLE BIOABSORBABLE DRUG ELUTING FLEXIBLE STENT
Polymeric materials may be utilized to fabricate stents. The stents may be balloon expandable or self-expanding. The polymeric materials may include additives such as drugs or other bioactive agents as well as plasticizers and/or radiopaque agents. The polymeric stent (1000) has a plurality of hoop components (1002) interconnected by at least one flexible straight connector (1004). The hoop components (1002) are formed as a continuous series of alternating substantially longitudinally oriented strut members (1006) and connector junction struts (1010), whereas the longitudinal strut (1006) is connected to the connector junction strut (1010) by alternating substantially circumferentially oriented arc members (1008).
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
The present invention relates to bone anchors, particularly of the type for fixing medical devices to bone. The bone anchor system includes a bone-anchoring element that has super elastic and/or shape memory components that extend radially outward for engaging the bone.
A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
Laser cut bioabsorbable intraluminal devices or stents and methods for forming such an intraluminal device or stent. A precursor sheet (100) or tube (200) of bioabsorbable material is laser cut in the presence of an inert gas to form an intraluminal medical device or stent having a desired geometry or pattern. The device or stent may comprise a helical, or other shape, having the laser cut geometry or pattern imparted thereon. The device or stent may further comprise drugs or bio-active agents incorporated into or onto the device or stent in greater percentages than conventional devices or stents. Radiopaque materials may be incorporated into, or coated onto, the intraluminal device or stent. Precise geometries or patterns are simply and readily achievable using the laser cutting methods in the presence of an inert gas while minimizing damage to the precursor materials.
A bioabsorbable drug delivery device and various methods of making the same. The devices are preferably formed from bioabsorbable materials using low temperature fabrication processes, whereby drugs or other bio-active agents are incorporated into or onto the device and degradation of the drugs or other agents during processing is minimized. Radiopaque markers may also be incorporated into, or onto, the devices. The devices may be generally tubular helical stents comprised of a solid ladder or an open lattice configuration, or a hybrid combination thereof. The tubular helical stents are generally formed from precursor fibers, films or tubes.
A bioabsorbable drug delivery device and various methods of making the same. The devices are preferably formed from bioabsorbable materials using low temperature fabrication processes, whereby drugs or other bio-active agents are incorporated into or onto the device and degradation of the drugs or other agents during processing is minimized. The method includes the steps of preparing a solution of at least one bioabsorbable polymer with a solvent and pouring the solution into a mold. The solvent is then evaporated in a nitrogen environment and the solution is converted into a film. The film is then removed from the mold and residual solvent is removed from the film. The film is then cut into strips and stored in an inert environment.
A bioabsorbable drug delivery device and various methods of making the same. The devices are preferably formed from bioabsorbable materials using low temperature fabrication processes,whereby drugs or other bio-active agents are incorporated into or onto the device and degradation of the drugs or other agents during processing is minimized. The method includes preparing a solution of at least one bioabsorbable polymer and a solvent. The solution is then deposited onto a mandrel and converted into a tube. The solvent is evaporated from the tube in a nitrogen rich environment. The tube is removed from the mandrel and further dried before being stored in an inert environment.
The present disclosure concerns a delivery system for delivering a medically useful payload through the vasculature to a site of interest in the patient's body. The medically useful payload may be a therapeutic device, such as a stent, and it may be a diagnostic tool, such as an imaging device. Owing to its structural attributes, the presently- inventive delivery system is well suited for carrying medical payload to and through vessel curvature and to branched regions (i.e., bifurcations) in same. Also, the device is well-suited to traveling through a vessel over a guiding element, such as a guidewire, which itself exhibits curvature.
Vessel wound closure systems and method for sealing a puncture wound in a target vessel, such as those puncture wounds that occur from prior interventional procedures. A sealing member (40) is deployed intravascularly into the target vessel, and an anchor member (50) is deployed extravascularly of the target vessel. The sealing member and the anchor member are connected by a suture (60) that may be drawn to tighten the sealing member and the anchor member relative to one another in order to effect the seal of the puncture wound. After tightening, the suture is secured to maintain the sealing member and the anchor member relative to one another in order to maintain the seal. Preferably, the anchor member, the suture and the sealing member are comprised of biocompatible, bioresorbable materials that are absorbed into the body after the sealing of the puncture wound has been achieved. The sealing member, suture and the anchor member are delivered by a delivery rod (50) or other components over a guidewire (30) or through an introducer already in place from the preceding interventional procedure.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
Vessel wound closure systems and method for sealing a puncture wound in a target vessel, such as those puncture wounds that occur from interventional procedures. The vessel wound closure system generally comprises an introducer (10) and a hydratable hemostatic membrane (30) dislodgable from over a portion of the introducer to seal a vessel wound upon hydration of the membrane. The membrane may include a glaze on an outside surface thereof to help contorl hydration of the membrane.
A balloon catheter for use with an endoscope may have a flexible shaft extending between a proximal and distal end, with a hub affixed to the proximal end, and a balloon that is longitudinally asymmetrical. A balloon may have a central or cylindrical working portion, flanked by proximal and distal tapering portions, which are in turn flanked by proximal and distal balloon legs, which are affixed to the catheter shaft. In more specific detail, a longitudinally asymmetrical balloon may have proximal and distal tapering portions that have a relatively steep and a relatively shallow tapering angle, respectively. An optional additional feature of such a balloon catheter is that the catheter shaft may have a high pull strength and low longitudinal elongation, by including some type of reinforcement.
Vessel wound closure systems and method for sealing a puncture wound in a target vessel, such as those puncture wounds that occur from interventional procedures. The vessel wound closure system comprises at least a biocomatible, visoelastic, self-sealing septum material injected onto the adventitia of the target vessel prior to performance of an interventional procedure. The prior injected septum material remains and seals the puncture wound of the target vessel even after various components associated with accessing the target vessel and the performance of the interventional procedure are removed from the target vessel and the puncture wound.
The present invention discloses a block copolymer having a hydrophobic block, a hydrophilic block, and a biologically active block. The biologically active block is directly adjacent to the hydrophilic block. Preferably, the block copolymer is prepared through reversible addition fragmentation transfer (RAFT) polymerization. The present invention also discloses a coating composition comprising the inventive block copolymer. The coating composition may be used for applying on at least a portion of one surface of an article. Moreover, the present invention discloses an article having the inventive coating composition thereon. Preferably, the article is a medical device or a component of a medical device.
C08F 20/30 - Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
C08F 26/06 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
C09D 153/00 - Coating compositions based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCoating compositions based on derivatives of such polymers
Self-expanding stent delivery systems and methods having an introducer that receives a delivery catheter. The delivery catheter includes an outer body, an inner body and a stent loaded onto a stent bed within the inner body. At least one anchoring mechanism provided on the inner body helps maintain the undeployed loaded stent appropriately in the stent bed during deployment. The at least one anchoring mechanism can include radiopaque material to increase fluoroscopic visualization of the stent during deployment, and the self-expanding stent can be a bio-absorbable material including drugs or other bio-active agents incorporated therein or provided thereon. After deployment of the stent at the intended treatment site, removal of the inner body and outer body of the delivery catheter and of the introducer occurs.
This invention relates generally to an expandable intraluminal medical device for use within a body passageway or duct, and more particularly to a stent having a plurality of hoop sections. Each hoop section comprises a tubular configuration of structural elements having proximal and distal open end, and defining a longitudinal axis extending there between. A set of flex connectors connects each adjacent hoop section. Each set of flex connectors comprises one or more flex connector members arranged in the same geometric orientation. Adjacent sets of flex connectors comprise one or more flex connector members arranged in an opposite geometric orientation.
A61F 2/91 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
The present invention relates to devices for closing passageway in a body, for example a patent foramen oval (PFO) in a heart, and related methods of using suc closure devices for closing the passageway. The metho includes introducing a mechanical closure device into a atrium of the heart and transeptally deploying th closure device across the interatrial septum to provid proximation of the septum secundum and septum primum.
The present invention relates to a delivery system for delivering a device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The delivery system has an elongate member having a proximal and distal end. A deflectable needle assembly having luminal and abluminal surfaces is slideably engaged within the elongate member. An actuator is slideabley engaged within the elongate member and attached to the needle tip assembly such that translational movement of the actuator causes deflection of the deflectable needle assembly.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
A device and method for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The deployment device has a first tubular structure having proximal and distal ends. A second tubular structure is substantially coaxial to and slideably engaged within the first tubular structure. The second tubular structure has a first substantially linear shape when constrained within the first tubular structure, and a second curvilinear shape when telescopically extended from the distal end of the first tubular structure. A third tubular structure is substantially coaxial to and slideably engaged within the second tubular structure. The third tubular structure is configured to provide sufficient rigidity to push the mechanical closure device from the distal end of the second tubular structure, and provide sufficient flexibility to assume a curvilinear shape when deflected by the second tubular structure.
A stent or other intraluminal medical device having markers formed from housings integral with the stent and marker inserts having a higher radiopacity than the stent provides for more precise placement and post-procedural visualization in a vessel, by increasing the radiopacity of the stent under-X- ray fluoroscopy. The housings are formed integral to the stent and the marker inserts are made from a material close in the galvanic series to the stent material and sized to substantially minimize the effect of galvanic corrosion. The housings are also shaped to minimize their impact on the overall profile of the stent. The stent or other intraluminal medical device may also be fabricated from an alloy having a higher radiopacity without sacrificing any properties of the base alloy forming the stent or other intraluminal medical device.
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
