Goods & Services

Probiotic bacteria sold as a component of dietary supplements; probiotic bacteria sold as a component of probiotic supplements; probiotic bacteria sold as a component of dietary supplements for mixing with food or drink; probiotic bacteria sold as a component of nutritional supplements; probiotic bacteria sold as a component of nutritional supplements for mixing with food or drink; probiotic bacteria sold as a component of beverages for use as a nutritional supplements; probiotic bacteria sold as a component of probiotic supplements for mixing with food or drink; probiotic supplements. Probiotic bacteria sold as a component of mixes, powders, and concentrates for making non-alcoholic water-based beverages.

Goods & Services

Probiotic bacteria sold as a component of dietary supplements; probiotic bacteria sold as a component of probiotic supplements; probiotic bacteria sold as a component of dietary supplemental drinks; probiotic bacteria sold as a component of dietary supplements for mixing with food or drink; probiotic bacteria sold as a component of nutritional supplements; probiotic bacteria sold as a component of nutritional supplements for mixing with food or drink; probiotic bacteria sold as a component of beverages for use as a nutritional supplements; probiotic bacteria sold as a component of probiotic supplements for mixing with food or drink; probiotic supplements. Probiotic bacteria sold as a component of water-based non-alcoholic beverages.

Goods & Services

(1) Probiotic bacteria sold as a component of dietary supplements; probiotic bacteria sold as a component of probiotic supplements; probiotic bacteria sold as a component of dietary supplements for mixing with food or drink; probiotic bacteria sold as a component of nutritional supplements; probiotic bacteria sold as a component of nutritional supplements for mixing with food or drink; probiotic bacteria sold as a component of beverages for use as a nutritional supplements; probiotic bacteria sold as a component of probiotic supplements for mixing with food or drink; probiotic supplements. (2) Probiotic bacteria sold as a component of mixes, powders, and concentrates for making non-alcoholic water-based beverages.

Goods & Services

(1) Probiotic bacteria sold as a component of dietary supplements; probiotic bacteria sold as a component of probiotic supplements; probiotic bacteria sold as a component of dietary supplemental drinks; probiotic bacteria sold as a component of dietary supplements for mixing with food or drink; probiotic bacteria sold as a component of nutritional supplements; probiotic bacteria sold as a component of nutritional supplements for mixing with food or drink; probiotic bacteria sold as a component of beverages for use as a nutritional supplements; probiotic bacteria sold as a component of probiotic supplements for mixing with food or drink; probiotic supplements. (2) Probiotic bacteria sold as a component of water-based non-alcoholic beverages.

Goods & Services

Nutraceuticals for use as a dietary supplement; nutraceuticals for use as a dietary supplement for use in conjunction with alcohol consumption; probiotic supplements; beverages containing a bioengineered probiotic for use as a nutritional supplement; dietary supplemental drinks; nutritional supplements, namely, probiotic compositions. Non-alcoholic water-based beverages; non-alcoholic water-based beverages also containing a bioengineered probiotic; non-alcoholic water-based beverages also containing a bioengineered probiotic for use in conjunction with alcohol consumption.

Goods & Services

(1) Nutraceuticals for use as a dietary supplement; nutraceuticals for use as a dietary supplement for use in conjunction with alcohol consumption; probiotic supplements; beverages containing a bioengineered probiotic for use as a nutritional supplement; dietary supplemental drinks; nutritional supplements, namely, probiotic compositions. (2) Non-alcoholic water-based beverages; non-alcoholic water-based beverages also containing a bioengineered probiotic; non-alcoholic water-based beverages also containing a bioengineered probiotic for use in conjunction with alcohol consumption.

Goods & Services

Probiotic bacteria sold as a component of water-based non-alcoholic beverages Probiotic bacteria sold as a component of dietary supplements; Probiotic bacteria sold as a component of probiotic supplements; Probiotic bacteria sold as a component of dietary supplemental drinks; Probiotic bacteria sold as a component of dietary supplements for mixing with food or drink; Probiotic bacteria sold as a component of nutritional supplements; Probiotic bacteria sold as a component of nutritional supplements for mixing with food or drink; Probiotic bacteria sold as a component of beverages for use as a nutritional supplements; Probiotic bacteria sold as a component of probiotic supplements for mixing with food or drink; Probiotic supplements

Goods & Services

Probiotic bacteria sold as a component of mixes, powders, and concentrates for making non-alcoholic water-based beverages Probiotic bacteria sold as a component of dietary supplements; Probiotic bacteria sold as a component of probiotic supplements; Probiotic bacteria sold as a component of dietary supplements for mixing with food or drink; Probiotic bacteria sold as a component of nutritional supplements; Probiotic bacteria sold as a component of nutritional supplements for mixing with food or drink; Probiotic bacteria sold as a component of beverages for use as a nutritional supplements; Probiotic bacteria sold as a component of probiotic supplements for mixing with food or drink; Probiotic supplements

Abstract

Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

IPC Classes  ?

• A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61K 35/741 - Probiotics
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 39/02 - Antidotes
• C07K 14/32 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Bacillus (G)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

The present disclosure provides methods and compositions that promote gut health. In some cases, the compositions comprise dietary fibers.

IPC Classes  ?

• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics

Abstract

The present disclosure provides methods and compositions that promote gut health. In some cases, the compositions comprise dietary fibers.

IPC Classes  ?

• A61K 31/718 - Starch or degraded starch, e.g. amylose, amylopectin
• A61K 31/736 - Glucomannans or galactomannans, e.g locust bean gum, guar gum
• A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61K 36/77 - Sapindaceae (Soapberry family), e.g. lychee or soapberry
• A61K 36/82 - Theaceae (Tea family), e.g. camellia
• A61K 36/9066 - Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

The present disclosure provides solutions to various challenges in health, including health challenges related to high consumption of carbohydrate and/or low consumption of soluble fiber. The present disclosure provides, among other things, bacteria engineered for expression of a fiber-synthesizing enzyme, e.g., for expression of the enzyme in the gut (e.g., in the intestine). In particular embodiments, the present disclosure provides bacteria engineered for expression of a fiber-synthesizing enzyme that consumes carbohydrate in the process of synthesizing fiber, e.g., in the gut. The present disclosure further includes formulations of isolated fiber-synthesizing enzymes for administration to subjects.

IPC Classes  ?

• A61K 38/45 - Transferases (2)
• C12N 9/10 - Transferases (2.)
• C12N 9/90 - Isomerases (5.)
• C12N 15/75 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
• C12N 1/20 - BacteriaCulture media therefor
• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61K 35/745 - Bifidobacteria
• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• A61K 38/47 - Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases

Abstract

The present disclosure provides solutions to various challenges in health, including health challenges related to high consumption of carbohydrate and/or low consumption of soluble fiber. The present disclosure provides, among other things, bacteria engineered for expression of a fiber-synthesizing enzyme, e.g., for expression of the enzyme in the gut (e.g., in the intestine). In particular embodiments, the present disclosure provides bacteria engineered for expression of a fiber-synthesizing enzyme that consumes carbohydrate in the process of synthesizing fiber, e.g., in the gut. The present disclosure further includes formulations of isolated fiber-synthesizing enzymes for administration to subjects.

IPC Classes  ?

• A61K 35/74 - Bacteria
• A61K 35/741 - Probiotics
• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• A61K 35/745 - Bifidobacteria
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material

Abstract

Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

IPC Classes  ?

• A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 39/02 - Antidotes
• C07K 14/32 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Bacillus (G)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61K 35/741 - Probiotics
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

IPC Classes  ?

• A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• A61K 35/741 - Probiotics
• A61P 39/02 - Antidotes
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C07K 14/32 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Bacillus (G)
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

IPC Classes  ?

• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
• C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
• A61K 35/74 - Bacteria
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria

Abstract

Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

IPC Classes  ?

• A61K 35/741 - Probiotics
• A61P 39/02 - Antidotes
• A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C07K 14/32 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Bacillus (G)
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61K 38/00 - Medicinal preparations containing peptides

Goods & Services

Nutraceuticals for use as a dietary supplement; Nutraceuticals for use as a dietary supplement for use in conjunction with alcohol consumption; Probiotic supplements; Beverages containing a bioengineered probiotic for use as a nutritional supplement; Dietary supplemental drinks; Nutritional supplements, namely, probiotic compositions Non-alcoholic water-based beverages; Non-alcoholic water-based beverages also containing a bioengineered probiotic; Non-alcoholic water-based beverages also containing a bioengineered probiotic for use in conjunction with alcohol consumption

Goods & Services

Nutraceuticals for use as a dietary supplement; Nutraceuticals for use as a dietary supplement for use in conjunction with alcohol consumption; Probiotic supplements; Beverages containing a bioengineered probiotic for use as a nutritional supplement; Dietary supplemental drinks; Nutritional supplements, namely, probiotic compositions Non-alcoholic water-based beverages; Non-alcoholic water-based beverages also containing a bioengineered probiotic; Non-alcoholic water-based beverages also containing a bioengineered probiotic for use in conjunction with alcohol consumption