Methods and systems to capture and analyze aerosolized particles in exhaled air including protein biomarkers and their truncated proteoforms using a wetted-packed bed column. Exhaled air may be collected from an individual breathing using a ventilator. The truncated proteoforms may be characteristic of tuberculosis. The captured particles are eluted using one or more solvents and analyzed using devices including MALDI-TOFMS. At least one of prediction accuracy, precision, or recall associated with tuberculosis detection using the methods and systems is at least 90%.
A61B 5/08 - Measuring devices for evaluating the respiratory organs
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
Methods and devices for capturing aerosolized organic biomaterials including proteases in exhaled air using packed bed columns to enable rapid, low-cost detection of several diseases including respiratory tract infections. Methods and devices for capturing neutrophil elastase in exhaled air and examining neutrophil elastase proteolysis activity using a substrate-based probe and MALDI-TOFMS to detect respiratory tract infections are disclosed.
Systems and methods for capturing and analyzing non-volatile organic aerosolized particles in exhaled breath to enable rapid, low-cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The systems and methods selectively capture aerosolized non-volatile organic particles in exhaled breath particles using a packed bed column disposed in an exhaled breath capture module. The captured non-volatile organic particles are eluted using solvents and analyzed using analytical devices including MALDI-TOFMS.
Systems for identifying the composition of bioaerosol particles using a TOFMS MALDI matrix-less system. A continuous timing laser triggers an IR ionization laser to fire when each particle enters the beam of the continuous trigger laser and is used to determine optical properties of the aerosol particles in association with one or more laser scattering devices and generate optical data. Ionized fragments produced when each particle is struck by the pulse ionization laser are analyzed using a TOFMS detector. A data analysis system is configured to compile the optical data with unique mass spectral data associated with each particle using data fusion and compare the compiled optical data with a training data set comprising of a knowledge base of known aerosol particles to predict composition.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/00 - Particle spectrometers or separator tubes
H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Scientific apparatus, namely, mass spectrometers and parts thereof, in particular, time-of-flight mass spectrometers and aerosol time-of-flight mass spectrometers; downloadable computer programs and computer software for operating mass spectrometers; downloadable computer programs and computer software, in particular, deep learning algorithms, for analyzing and displaying spectral data recorded by mass spectrometers, in particular, to identify chemicals, biological molecules such as peptide and proteins, and microorganisms, such as bacteria, yeasts, viruses or fungi, in aerosol analytes, biological, chemical, industrial and food samples Diagnostic instruments, in particular, mass spectrometer systems for identifying chemicals, biological molecules such as peptide and proteins, and microorganisms, such as bacteria, yeasts, viruses or fungi, in aerosol analytes, biological, chemical, industrial and food samples for use in the identification of pathogens that cause infectious diseases and food-borne diseases, identification of pathogens in the point of care diagnostics market, and identification of biological and chemical threat agents; aerosol sample collection devices and sample preparation devices, in particular, for mass spectrometry, time-of-flight mass spectrometry and aerosol time-of-flight mass spectrometry for use in the identification of pathogens that cause infectious diseases and food-borne diseases, identification of pathogens in the point of care diagnostics market, and identification of biological and chemical threat agents
7.
DIAGNOSIS OF TUBERCULOSIS AND OTHER DISEASES USING EXHALED BREATH
Disclosed are methods and devices for analyzing aerosol particles in exhaled breath using diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for capturing exhaled breath aerosols in a packed bed column and analyzing exhaled captured breath aerosols for tuberculosis diagnosis.
A61B 5/091 - Measuring volume of inspired or expired gases, e.g. to determine lung capacity
A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.
G01N 1/22 - Devices for withdrawing samples in the gaseous state
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
G01N 27/626 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using heat to ionise a gas
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
Systems are methods for identifying the composition of non-biological aerosol particles or biological aerosol particles including water bound to the surface of the particles, without pre-treatment using complex organic MALDI matrices. A continuous timing laser may be used to index the aerosol particles, determine optical particle properties, and trigger an IR pulse ionization laser. Ionized fragments, and optionally photons, associated with each particle produced by ionization of the particles the IR ionization laser is analyzed using one or more detectors including a TOFMS detector and an optical detector. Unique mass spectral data and optical data associated with each indexed particle is compiled using data fusion to generate a compiled data set. The compiled optical data is compared with a training data set comprising a knowledge base of known aerosol particles to predict aerosol particle composition.
G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
H01J 49/00 - Particle spectrometers or separator tubes
Systems for identifying the composition of aerosol particles, particularly that of non-biological aerosol particles or biological aerosol particles including surface-bound water. A continuous timing laser triggers an IR ionization laser to fire when each particle enters the beam of the continuous trigger laser and determine optical properties of the aerosol particles in association with one or more laser scattering devices and generate optical data. The continuous laser beam and the pulse ionization laser beam are disposed as overlapping beams. Ionized fragments produced when each particle is struck by the ionization laser are analyzed using a TOFMS detector. A data analysis system is configured to compile the optical data with unique mass spectral data associated with each particle using data fusion and compare the compiled optical data with a training data set comprising of a knowledge base of known aerosol particles to predict composition.
G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
H01J 49/00 - Particle spectrometers or separator tubes
In-vehicle occupant detection system and methods capable of monitoring the interior of a passenger vehicle and responding to potentially dangerous situations are disclosed. The detection systems may comprise a front camera to focus on driver and passenger behavior in the front cabin, and a rear camera and an array of environmental sensors to detect unattended occupants including children, adults or pets in the rear seats. Data may be processed by an intelligent algorithm to assesses anomalies and trigger one or more alarms or countermeasures.
Systems and methods to eradicate insects using microwave radiation at ± 250 MHz of the resonance frequency of insects and without the use of chemicals. An insect eradication system includes one or more RF shielding layers supported on a collapsible frame and configured to form a canopy over infested objects including beds. A mobile cart disposed adjacent to the insect-infested object houses a microwave generator, power supply module, control module, and microwave transmission components. The incident microwave radiation frequency at ± 250 MHz of the resonance frequency of the insects rapidly increases the temperature inside the carapace of the insect by flash heating and kills the insects while only minimally increasing the temperature of the insect-infected objects.
Methods and devices for capturing and analyzing aerosolized particles in exhaled breath characteristic of a respiratory disease to enable rapid, low-cost point of care assays for several diseases including respiratory tract diseases such as COVID-19 are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using solvents and analyzed using analytical devices including MALDI-TOFMS.
Methods and systems to detect an anomaly caused by unknown aerosol hazardous particles in an environment using single particle mass spectra of environmental aerosol samples. An autoencoder is trained using a dataset of single particle mass spectra to diagnose an anomaly in the environment. To test the autoencoder's ability to predict known hazardous substances as anomalies, a reference mass spectra data set is generated using simulated composite mass spectra of hazardous analyte particles in the background environment in silica at different analyte concentrations.
Methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low-cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.
Mobile decontamination systems and microwave assisted decontamination methods for decontaminating a variety of contaminated surfaces disposed external to the system. The systems and methods include treating the surfaces with benign chemical formulations followed by exposing to microwave irradiation for short periods of time to achieve at least 6-log reduction in biological contaminants including viruses and spores of B. anthracis, B. thuringiensis, and P. roqueforti. The formulations include a percarbonate and surfactant in water.
Methods and devices to capture and analyze aerosolized particles in exhaled air including protein biomarkers and their truncated proteoforms characteristic of tuberculosis to enable rapid detection of diseases. Methods and systems to selectively capture aerosolized particles using a packed bed column. The captured particles are eluted using one or more solvents and analyzed using devices including MALDI-TOFMS.
A61B 5/08 - Measuring devices for evaluating the respiratory organs
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
Methods and devices to capture and analyze aerosolized particles including protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases. Methods and systems to selectively capture aerosolized particles using a packed bed column. The captured particles are eluted using one or more solvents and analyzed using devices including mass spectrometry.
A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/00 - Particle spectrometers or separator tubes
20.
Diagnosis of respiratory diseases using analysis of exhaled breath and aerosols
Disclosed are methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.
Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles. A continuous timing laser tightly coupled with a pulse ionization laser is used to index aerosol particles, measure particle properties, and trigger the ionization laser to fire when each particle enters the beam of the trigger laser. Ionized fragments and optionally photons produced when each particle is struck by the ionization laser are analyzed using one or more detectors including a TOF-MS detector and an optical detector. Individual single particle spectra are aligned and denoised prior to averaging.
Disclosed are methods and devices for analyzing aerosol particles in exhaled breath using diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for capturing exhaled breath aerosols in a packed bed column and analyzing exhaled captured breath aerosols for tuberculosis diagnosis.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
P. roqueforti. Chemical formulations may comprise copper (II) chloride in water. The formulations may include a surfactant such as a polyethylene sorbitol ester surfactant.
Disclosed are systems and methods to provide rapid and autonomous detection of analyte particles in gas and liquid samples. Disclosed are methods and devices for identifying biological aerosol analytes using MALDI-MS and chemical aerosol analytes using LDI and MALDI-MS using time-of-flight mass spectrometry (TOFMS).
H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
G01N 1/22 - Devices for withdrawing samples in the gaseous state
G01N 27/626 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using heat to ionise a gas
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
25.
CAPTURING TRUNCATED PROTEOFORMS IN EXHALED BREATH FOR DIAGNOSIS AND TREATMENT OF DISEASES
Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.
A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
Disclosed are methods and devices for analyzing exhaled breath aerosols and exhaled breath condensates using various diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for analyzing exhaled breath aerosols and exhaled breath condensates for tuberculosis diagnosis using mass spectrometry, including MALDI-MS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.
Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
Methods and devices for capturing and analyzing aerosolized particles in exhaled breath characteristic of a respiratory disease to enable rapid, low-cost point of care assays for several diseases including respiratory tract diseases such as COVID-19 are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using solvents and analyzed using analytical devices including MALDI-TOFMS.
A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
29.
Methods and systems for detecting aerosol particles without using complex organic MALDI matrices
Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles, without pre-treatment using complex organic MALDI matrices. A continuous timing laser may be used to index aerosol particles, measure particle properties, and trigger a pulse ionization laser. Ionized fragments and optionally photons associated with each particle producing by the ionization laser may be analyzed using one or more detectors including a TOF-MS detector and an optical detector. The laser pulse may comprise a simultaneous IR and UV laser pulse when fragments comprise predominantly of UV chromophores. Unique spectral data associated with each indexed particle from each detector may be compiled using data fusion to generate compiled spectral data. Machine learning methods may be used to improve the prediction of composition over time.
G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
H01J 49/00 - Particle spectrometers or separator tubes
Disclosed are methods and systems for analyzing exhaled breath aerosol particles present in the ambient environment using high flowrate aerosol collector systems and sensitive and specific nucleic acid analysis systems to determine if active spreaders of a respiratory disease are present in an indoor space. The disclosed systems and methods provide for a diagnostic test result in less than about 30 minutes.
G01N 1/22 - Devices for withdrawing samples in the gaseous state
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
31.
Microwave assisted methods and systems for surface decontamination
P. roqueforti. Chemical formulations may comprise copper (II) chloride in water. The formulations may include a surfactant such as a polyethylene sorbitol ester surfactant.
Devices and methods for enhanced hearing protection for animals are disclosed. Passive noise reduction components provide reduction of at least 20 dB to 30 dB in dogs using flexible soft muffs that are housed in a hearing protection sleeve. Active noise cancellation (ANC) features may also be used to increase noise reduction to about 40 dB over a large frequency range. The devices may employ passive noise reduction electronic bypass to measure and playback sounds at safe levels bypassing at least one of ANC and passive noise reduction. Communication components may be employed to provide for communication between the handler and the animal. The systems and methods may be used to protect the hearing and utility of military working dogs and hunting dogs.
A01K 13/00 - Devices for grooming or caring of animals, e.g. curry-combsFetlock ringsTail-holdersDevices for preventing crib-bitingWashing devicesProtection against weather conditions or insects
33.
Methods and systems for detecting aerosol particles
Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles. A continuous timing laser tightly coupled with a pulse ionization laser is used to index aerosol particles, measure particle properties, and trigger the ionization laser to fire when each particle enters the beam of the trigger laser. Ionized fragments and optionally photons produced when each particle is struck by the ionization laser are analyzed using one or more detectors including a TOF-MS detector and an optical detector. Individual single particle spectra are aligned and denoised prior to averaging.
G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
H01J 49/00 - Particle spectrometers or separator tubes
Disclosed are methods and devices for analyzing aerosol particles in exhaled breath using diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for capturing exhaled breath aerosols in a packed bed column and analyzing exhaled captured breath aerosols for tuberculosis diagnosis.
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/091 - Measuring volume of inspired or expired gases, e.g. to determine lung capacity
A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
Disclosed are methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
37.
Mobile systems for microwave assisted surface decontamination and decontamination methods
Systems and methods for enhanced hearing protection and data recording are disclosed. Recorded data is analyzed to determine user compliance with standard operating procedures. Additionally, hearing loss is monitored using neurological response of the auditory system to environmental noise. Optional sensors such as temperature sensors, accelerometers, GPS sensors are used to correlate noise data with external events. An optional acoustic source may be used to identify unusual conditions such as ear drum perforations and capture information related to health of the tympanic membrane and external auditory meatus. The systems and methods may also be used to protect the hearing and utility of military working dogs.
G10K 11/178 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using interference effectsMasking sound by electro-acoustically regenerating the original acoustic waves in anti-phase
A61F 11/08 - Protective devices for the ears internal, e.g. earplugs
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/388 - Nerve conduction study, e.g. detecting action potential of peripheral nerves
39.
METHODS AND SYSTEMS FOR DETECTING AEROSOL PARTICLES WITHOUT USING COMPLEX ORGANIC MALDI MATRICES
Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles, without pre-treatment using complex organic MALDI matrices. A continuous timing laser may be used to index aerosol particles, measure particle properties, and trigger a pulse ionization laser. Ionized fragments and optionally photons associated with each particle producing by the ionization laser may be analyzed using one or more detectors including a TOF-MS detector and an optical detector. The laser pulse may comprise a simultaneous IR and UV laser pulse when fragments comprise predominantly of UV chromophores. Unique spectral data associated with each indexed particle from each detector may be compiled using data fusion to generate compiled spectral data. Machine learning methods may be used to improve the prediction of composition over time.
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
G01N 27/64 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
G01N 33/483 - Physical analysis of biological material
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
40.
SYSTEMS AND METHODS OF RAPID AND AUTONOMOUS DETECTION OF AEROSOL PARTICLES
Disclosed are systems and methods to provide rapid and autonomous detection of analyte particles in gas and liquid samples. Disclosed are methods and devices for identifying biological aerosol analytes using MALDI-MS and chemical aerosol analytes using LDI and MALDI-MS using time-of- flight mass spectrometry (TOFMS).
Disclosed are methods and devices for analyzing exhaled breath aerosols and exhaled breath condensates using various diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for analyzing exhaled breath aerosols and exhaled breath condensates for tuberculosis diagnosis using mass spectrometry, including MALDI-MS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/097 - Devices for facilitating collection of breath or for directing breath into or through measuring devices
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
42.
MICROWAVE ASSISTED METHODS AND SYSTEMS FOR SURFACE DECONTAMINATION
B. anthracis, B. thuringiensisP. roquefortiP. roqueforti. Chemical formulations may comprise copper (II) chloride in water. The formulations may include a surfactant such as a polyethylene sorbitol ester surfactant.
Coating materials such as MALDI matrix solutions are aerosolized and are used to coat analyte particles in an acoustic coater. Methods and devices for coating analyte particles in real time are disclosed. The coating improves the detection and quantification of the analyte particles using analytical instruments such as an aerosol time of flight mass spectrometer.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
B05B 17/06 - Apparatus for spraying or atomising liquids or other fluent materials, not covered by any other group of this subclass operating with special methods using ultrasonic vibrations
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
Devices and methods for enhanced hearing protection for animals are disclosed. Passive noise reduction components provide reduction of at least 20 dB to 30 dB in dogs using flexible soft muffs that are housed in a hearing protection sleeve. Active noise cancellation (ANC) features may also be used to increase noise reduction to about 40 dB over a large frequency range. The devices may employ passive noise reduction electronic bypass to measure and playback sounds at safe levels bypassing at least one of ANC and passive noise reduction. Communication components may be employed to provide for communication between the handler and the animal. The systems and methods may be used to protect the hearing and utility of military working dogs and hunting dogs.
A01K 13/00 - Devices for grooming or caring of animals, e.g. curry-combsFetlock ringsTail-holdersDevices for preventing crib-bitingWashing devicesProtection against weather conditions or insects
Systems and methods for enhanced hearing protection and data recording are disclosed. Recorded data is analyzed to determine user compliance with standard operating procedures. Additionally, hearing loss is monitored using neurological response of the auditory system to environmental noise. Optional sensors such as temperature sensors, accelerometers, GPS sensors are used to correlate noise data with external events. An optional acoustic source may be used to identify unusual conditions such as ear drum perforations and capture information related to health of the tympanic membrane and external auditory meatus. The systems and methods may also be used to protect the hearing and utility of military working dogs.
In one aspect, a time-of-flight mass spectrometer includes a source comprising a backing plate configured to operably couple to a core sample containing component, and an acceleration region. The time-of-flight mass spectrometer also includes a time-of-flight mass analyzer operably associated with the source region. In some embodiments, the core sample core sample containing component is a coring drill bit. In some embodiments, core containing component is configured to couple to the backing plate of the source region from the opposite side of the acceleration region. In some embodiments, core containing component is configured to couple to the backing plate of the source region on the acceleration region side of the backing plate. In some embodiments, the acceleration region is a single-stage acceleration region. In other embodiments, the acceleration region is a two-stage acceleration region.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/00 - Particle spectrometers or separator tubes
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific apparatus, namely, mass spectrometers and parts
thereof, in particular, time-of-flight mass spectrometers
and aerosol time-of-flight mass spectrometers; computer
programs and computer software for operating mass
spectrometers; computer programs and computer software, in
particular, deep learning algorithms, for analyzing and
displaying spectral data recorded by mass spectrometers, in
particular, to identify chemicals and microorganisms, such
as bacteria, yeasts, viruses or fungi, in aerosol analytes,
biological, chemical, industrial and food samples. Diagnostic instruments, in particular, mass spectrometer
systems for identifying chemicals and microorganisms, such
as bacteria, yeasts, viruses or fungi, in aerosol analytes,
biological, chemical, industrial and food samples (terms
considered too vague by the International Bureau – (rule
13.2.b) of the Common Regulations); sample collection and
preparation devices for mass spectrometry, in particular,
for time-of-flight mass spectrometry and aerosol
time-of-flight mass spectrometry (terms considered too vague
by the International Bureau – (rule 13.2.b) of the Common
Regulations). Scientific and technological services for using mass
spectrometers, in particular, time-of-flight mass
spectrometers and aerosol time-of-flight mass spectrometers,
for identifying chemicals and microorganisms, such as
bacteria, yeasts, viruses or fungi, in aerosol analytes,
biological, chemical, industrial and food samples; design
and development of computer programs and computer software,
in particular, deep learning algorithms, for use with the
aforesaid goods and services.
48.
Coating of aerosol particles using an acoustic coater
Coating materials such as MALDI matrix solutions are aerosolized and are used to coat analyte particles in an acoustic coater. Methods and devices for coating analyte particles in real time are disclosed. The coating improves the detection and quantification of the analyte particles using analytical instruments such as an aerosol time of flight mass spectrometer.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
B05B 17/06 - Apparatus for spraying or atomising liquids or other fluent materials, not covered by any other group of this subclass operating with special methods using ultrasonic vibrations
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific apparatus, namely, mass spectrometers and parts thereof, in particular, time-of-flight mass spectrometers and aerosol time-of-flight mass spectrometers; computer programs and computer software for operating mass spectrometers; computer programs and computer software, in particular, deep learning algorithms, for analyzing and displaying spectral data recorded by mass spectrometers, in particular, to identify chemicals and microorganisms, such as bacteria, yeasts, viruses or fungi, in aerosol analytes, biological, chemical, industrial and food samples Diagnostic instruments, in particular, mass spectrometer systems for identifying chemicals and microorganisms, such as bacteria, yeasts, viruses or fungi, in aerosol analytes, biological, chemical, industrial and food samples for use in the identification of pathogens that cause infectious diseases and food-borne diseases, identification of pathogens in the point of care diagnostics market, and identification of biological and chemical threat agents; sample collection and preparation devices for mass spectrometry, in particular, for time-of-flight mass spectrometry and aerosol time-of-flight mass spectrometry for use in the identification of pathogens that cause infectious diseases and food-borne diseases, identification of pathogens in the point of care diagnostics market, and identification of biological and chemical threat agents Scientific and technological services in the nature of analytical testing services and research and development services for using mass spectrometers, in particular, time-of-flight mass spectrometers and aerosol time-of-flight mass spectrometers, for identifying chemicals and microorganisms, such as bacteria, yeasts, viruses or fungi, in aerosol analytes, biological, chemical, industrial and food samples; design and development of computer programs and computer software, in particular, deep learning algorithms, for use with the aforesaid goods and services
A miniature time-of-flight mass spectrometer (TOF-MS) was developed for a NASA/ASTID program beginning 2008. The primary targeted application for this technology is the detection of non-volatile (refractory) and biological materials on landed planetary missions. Both atmospheric and airless bodies are potential candidate destinations for the purpose of characterizing mineralogy, and searching for evidence of existing or extant biological activity.
A miniature time-of-flight mass spectrometer (TOF-MS) was developed for a NASA/ASTID program beginning 2008. The primary targeted application for this technology is the detection of non-volatile (refractory) and biological materials on landed planetary missions. Both atmospheric and airless bodies are potential candidate destinations for the purpose of characterizing mineralogy, and searching for evidence of existing or extant biological activity.
