The disclosure provides a flexible container configured to hold a fluid for pressurized dispensing, the flexible container including: a first flexible wall and a second flexible wall that are hermetically sealed together to form an internal space configured to hold the fluid; at least one outlet port configured for outputting the fluid from the internal space; and an enclosed spacer extending from the at least one outlet port into the internal space of the flexible container, the enclosed spacer configured to provide a fluid path from the internal space to the at least one outlet port during pressurized dispensing of the fluid that causes the first flexible wall and the second flexible wall to collapse onto each other and the enclosed spacer.
The invention provides methods of preparing lipid nanoparticles with biologically active agents associated with and/or encapsulated within the lipid nanoparticles. The method comprises the steps of (a) providing a first stream of a first liquid composition comprising an organic solution of one or more lipids; (b) providing a second stream of a second liquid composition comprising an aqueous solution of the biologically active agent; (c) mixing the first stream and the second stream such as to form a third stream of a third liquid composition comprising nascent lipid nanoparticles; (d) filling the third liquid composition into primary packaging containers without prior removal or addition of a constituent from or to the third liquid composition; and (e) subjecting the primary packaging containers to freeze drying such as to obtain a lyophilised composition. Steps (a) to (e) are conducted under aseptic conditions.
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
09 - Scientific and electric apparatus and instruments
11 - Environmental control apparatus
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical laboratory apparatus and instruments; laboratory apparatus and instruments for the synthesis of nanoparticles; laboratory mixers; static mixers being laboratory mixers; parts and accessories of the afore-mentioned goods, as far as included in class 9. Industrial chemical production installations; controlled mixers being parts of industrial chemical installations; chemical processing equipment; controlled mixers being parts of industrial installations for the production of nanoparticles; parts and accessories of the afore-mentioned goods, as far as included in class 11. Scientific research; pharmaceutical research and development services; research and development services relating to nanoparticles and to nanoparticle technology; development of chemical synthesis methods and production methods; scientific and technological consultancy relating to the syntheses and production of pharmaceuticals; scientific and technological consultancy relating to the syntheses and production of vaccines; scientific and technological consultancy relating to the syntheses and production of nanoparticles; laboratory research services relating to pharmaceuticals; laboratory research services relating to vaccines; laboratory research services relating to nanoparticles; working on and evaluation of chemical syntheses; pharmaceutical product evaluation; product evaluation related to nanoparticles and nanoparticle technology; consultancy relating to pharmaceutical research and development; consultancy relating to research and development in the field of nanoparticle syntheses and production; technological and/or scientific consultancy relating to product development in the field of nanotechnology; technological and/or scientific consultancy in the field of product development; industrial product development; conducting clinical trials for pharmaceutical products; material testing; technological and/or scientific assessment; testing; authentication; quality control.
09 - Scientific and electric apparatus and instruments
11 - Environmental control apparatus
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical laboratory apparatus and instruments; laboratory apparatus and instruments for the synthesis of nanoparticles; laboratory mixers; static mixers being laboratory mixers; parts and accessories of the afore-mentioned goods, as far as included in class 9. Industrial chemical production installations; controlled mixers being parts of industrial chemical installations; chemical processing equipment; controlled mixers being parts of industrial installations for the production of nanoparticles; parts and accessories of the afore-mentioned goods, as far as included in class 11. Scientific research; pharmaceutical research and development services; research and development services relating to nanoparticles and to nanoparticle technology; development of chemical synthesis methods and production methods; scientific and technological consultancy relating to the syntheses and production of pharmaceuticals; scientific and technological consultancy relating to the syntheses and production of vaccines; scientific and technological consultancy relating to the syntheses and production of nanoparticles; laboratory research services relating to pharmaceuticals; laboratory research services relating to vaccines; laboratory research services relating to nanoparticles; working on and evaluation of chemical syntheses; pharmaceutical product evaluation; product evaluation related to nanoparticles and nanoparticle technology; consultancy relating to pharmaceutical research and development; consultancy relating to research and development in the field of nanoparticle syntheses and production; technological and/or scientific consultancy relating to product development in the field of nanotechnology; technological and/or scientific consultancy in the field of product development; industrial product development; conducting clinical trials for pharmaceutical products; material testing; technological and/or scientific assessment; testing; authentication; quality control.
09 - Scientific and electric apparatus and instruments
11 - Environmental control apparatus
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical laboratory apparatus and instruments; laboratory apparatus and instruments for the synthesis of nanoparticles; laboratory mixers; static mixers being laboratory mixers; parts and accessories of the afore-mentioned goods, as far as included in class 9. Industrial chemical production installations; controlled mixers being parts of industrial chemical installations; chemical processing equipment; controlled mixers being parts of industrial installations for the production of nanoparticles; parts and accessories of the afore-mentioned goods, as far as included in class 11. Scientific research; pharmaceutical research and development services; research and development services relating to nanoparticles and to nanoparticle technology; development of chemical synthesis methods and production methods; scientific and technological consultancy relating to the syntheses and production of pharmaceuticals; scientific and technological consultancy relating to the syntheses and production of vaccines; scientific and technological consultancy relating to the syntheses and production of nanoparticles; laboratory research services relating to pharmaceuticals; laboratory research services relating to vaccines; laboratory research services relating to nanoparticles; working on and evaluation of chemical syntheses; pharmaceutical product evaluation; product evaluation related to nanoparticles and nanoparticle technology; consultancy relating to pharmaceutical research and development; consultancy relating to research and development in the field of nanoparticle syntheses and production; technological and/or scientific consultancy relating to product development in the field of nanotechnology; technological and/or scientific consultancy in the field of product development; industrial product development; conducting clinical trials for pharmaceutical products; material testing; technological and/or scientific assessment; testing; authentication; quality control.
A jet impingement reactor having a small, spheroidal reaction chamber is provided. The reaction chamber exhibits a first and a second fluid inlet arranged at opposite positions of the reaction chamber such as to point at one another, and wherein each of the first and the second fluid inlet comprises a nozzle. The distance between the nozzles is the same or smaller than the diameter of the reaction chamber along the first central axis. Preferably, the nozzles are comprised in fluid inlet connectors that are reversibly insertable into the wall of the reaction chamber such as to provide the first and the second fluid inlet. The invention further provides a method of mixing two fluids based on jet impingement using the reactor according to the invention.
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
B01J 4/00 - Feed devicesFeed or outlet control devices
B01J 14/00 - Chemical processes in general for reacting liquids with liquidsApparatus specially adapted therefor
B01J 19/02 - Apparatus characterised by being constructed of material selected for its chemically-resistant properties
The disclosure presented herein provides methods for producing a dispersion of nanoparticles, as for example liposomes, by a method comprising frontally colliding an organic stream with an aqueous stream at raised pressure.
An apparatus for mixing two liquids is provided. The apparatus comprises a static mixer, and a first (11) and second (12) feed module for feeding the two liquids to the mixer. The feed modules comprise pressurisable chambers (14a, 14b) for accommodating flexible containers which hold the liquids to be mixed. The liquids are forced through the static mixer when the chambers comprising the flexible containers are pressurised. Pressurisation is achieved by pressurised gas stored in pressure reservoir chambers (13a, 13b) that are connectable to the chambers holding the flexible containers. Related methods of mixing two liquids are also provided.
The invention provides a frame (10) for holding and arranging a static mixing device (16) along with flexible containers (11, 12, 13, 14) for liquid substrates, waste, and a liquid product. The frame comprises sealable regions for holding the containers and the flexible containers and the mixing device. Other aspects relate to kits comprising the frame together with one or more matching components, such as the static mixing device and the flexible containers; as well as apparatus for operating the frame in its assembled state, and methods comprising the use of the frame.
Disclosed is a jet impingement reactor having a housing made of a polymeric material, comprising at least two housing pieces that are affixed to one another. The housing encloses a substantially spherical reaction chamber (2) having at least two fluid inlets (3, 4) provided by nozzles (5) and a fluid outlet (6). Further provided are methods for making the reactor based on injection molding, as well as the use of the reactor for the aseptic manufacture of a sterile liquid pharmaceutical compositions, in particular compositions comprising nanoparticles such as lipid nanoparticles.
B01F 35/00 - Accessories for mixersAuxiliary operations or auxiliary devicesParts or details of general application
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
11.
TRANSMUCOSAL THERAPEUTIC SYSTEM CONTAINING A MACROLIDE IMMUNOSUPPRESSANT
The present invention relates to transmucosal therapeutic systems for the transmucosal administration of an active agent comprising a mucoadhesive layer structure comprising a macrolide immunosuppressant as active agent, such transmucosal therapeutic systems for use in a method of treatment and/or prophylaxis, and processes of manufacture of such transmucosal therapeutic systems.
A method for producing a liposome dispersion comprising at least one amphiphilic lipid, wherein the method comprises the steps of: providing a first stream (a) comprising an organic solvent, providing a second stream (b) comprising water, wherein at least one of first stream (a) and second stream (b) comprises the at least one amphiphilic lipid, ejecting the first stream (a) and the second stream (b) through pinholes, and frontally colliding the first stream (a) and the second stream (b), whereby the liposome dispersion comprising the at least one amphiphilic lipid is obtained.
An apparatus (1) for mixing two liquids is provided. The apparatus comprises a static mixer (2), and a first (6) and second (14) feed module for feeding the two liquids to the mixer. The feed modules comprise pressurisable chambers (7, 15) for accommodating flexible containers (8, 16) which hold the liquids to be mixed. The liquids are forced through the static mixer when the chambers comprising the flexible containers are pressurised. Pressurisation is achieved by pressurised gas stored in pressure reservoir chambers (11, 19) that are connectable to the chambers holding the flexible containers. Related methods of mixing two liquids are also provided.
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
The invention provides a method for validating the functioning of an apparatus with a static mixing device for mixing two liquid streams for producing nanoparticles. The static mixing device may be a jet impingement reactor. The method is based on the use of PLA, PLG or PLGA for producing polymeric nanoparticles with highly reproducible particle sizes. The invention further provides kits and liquid compositions for carrying out the method.
The invention provides a method for validating the functioning of an apparatus with a static mixing device for mixing two liquid streams for producing nanoparticles. The static mixing device may be a jet impingement reactor. The method is based on the use of PLA, PLG or PLGA for producing polymeric nanoparticles with highly reproducible particle sizes. The invention further provides kits and liquid compositions for carrying out the method.
The invention provides methods of preparing lipid nanoparticles with biologically active agents associated with and/or encapsulated within the lipid nanoparticles. The method comprises the steps of (a) providing a first stream of a first liquid composition comprising an organic solution of one or more lipids; (b) providing a second stream of a second liquid composition comprising an aqueous solution of the biologically active agent; (c) mixing the first stream and the second stream such as to form a third stream of a third liquid composition comprising nascent lipid nanoparticles; (d) filling the third liquid composition into primary packaging containers without prior removal or addition of a constituent from or to the third liquid composition; and (e) subjecting the primary packaging containers to freeze drying such as to obtain a lyophilised composition. Steps (a) to (e) are conducted under aseptic conditions.
A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61K 9/19 - Particulate form, e.g. powders lyophilised
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
09 - Scientific and electric apparatus and instruments
11 - Environmental control apparatus
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical laboratory reactors; chemical laboratory reactors for the synthesis of particles, in particular of nanoparticles; laboratory reactors for the synthesis of particles, in particular of nanoparticles; laboratory reactors for the production of individualized medicines and vaccines; parts and accessories of the aforementioned goods, as far as included in class 9. Reactors being industrial chemical installations; reactors for the industrial production of vaccines; reactors for the industrial production of pharmaceuticals; reactors for the industrial synthesis of nanoparticles; parts and accessories of the aforementioned goods, as far as included in class 11. Technological consultancy; development of chemical synthesis methods and production methods; scientific and technological consultancy relating to the syntheses and production of pharmaceuticals, vaccines and nanoparticles; development and design of chemical reactors and development of production methods; scientific research; pharmaceutical research and development services; laboratory research services relating to pharmaceuticals, vaccines and nanoparticles; working on and evaluation of chemical syntheses; pharmaceutical product evaluation; consultancy relating to pharmaceutical research and development; technological and/or scientific consultancy relating to product development in the field of nanotechnology; technological and/or scientific consultancy in the field of product development; industrial product development; conducting clinical trials for pharmaceutical products; material testing; technological and/or scientific assessment; testing; authentication; quality control.
09 - Scientific and electric apparatus and instruments
11 - Environmental control apparatus
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical laboratory reactors; chemical laboratory reactors for the synthesis of particles, in particular of nanoparticles; laboratory reactors for the synthesis of particles, in particular of nanoparticles; laboratory reactors for the production of individualized medicines and vaccines; parts and accessories of the aforementioned goods, as far as included in class 9. Reactors being industrial chemical installations; reactors for the industrial production of vaccines; reactors for the industrial production of pharmaceuticals; reactors for the industrial synthesis of nanoparticles; parts and accessories of the aforementioned goods, as far as included in class 11. Technological consultancy; development of chemical synthesis methods and production methods; scientific and technological consultancy relating to the syntheses and production of pharmaceuticals, vaccines and nanoparticles; development and design of chemical reactors and development of production methods; scientific research; pharmaceutical research and development services; laboratory research services relating to pharmaceuticals, vaccines and nanoparticles; working on and evaluation of chemical syntheses; pharmaceutical product evaluation; consultancy relating to pharmaceutical research and development; technological and/or scientific consultancy relating to product development in the field of nanotechnology; technological and/or scientific consultancy in the field of product development; industrial product development; conducting clinical trials for pharmaceutical products; material testing; technological and/or scientific assessment; testing; authentication; quality control.
09 - Scientific and electric apparatus and instruments
11 - Environmental control apparatus
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical laboratory reactors; chemical laboratory reactors for the synthesis of particles, in particular of nanoparticles; laboratory reactors for the synthesis of particles, in particular of nanoparticles; laboratory reactors for the production of individualized medicines and vaccines; parts and accessories of the aforementioned goods, as far as included in class 9. Reactors being industrial chemical installations; reactors for the industrial production of vaccines; reactors for the industrial production of pharmaceuticals; reactors for the industrial synthesis of nanoparticles; parts and accessories of the aforementioned goods, as far as included in class 11. Technological consultancy; development of chemical synthesis methods and production methods; scientific and technological consultancy relating to the syntheses and production of pharmaceuticals, vaccines and nanoparticles; development and design of chemical reactors and development of production methods; scientific research; pharmaceutical research and development services; laboratory research services relating to pharmaceuticals, vaccines and nanoparticles; working on and evaluation of chemical syntheses; pharmaceutical product evaluation; consultancy relating to pharmaceutical research and development; technological and/or scientific consultancy relating to product development in the field of nanotechnology; technological and/or scientific consultancy in the field of product development; industrial product development; conducting clinical trials for pharmaceutical products; material testing; technological and/or scientific assessment; testing; authentication; quality control.
09 - Scientific and electric apparatus and instruments
11 - Environmental control apparatus
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical laboratory reactors; chemical laboratory reactors for the synthesis of particles, in particular of nanoparticles; laboratory reactors for the synthesis of particles, in particular of nanoparticles; laboratory reactors for the production of individualized medicines and vaccines; parts and accessories of the aforementioned goods, as far as included in class 9. Reactors being industrial chemical installations; reactors for the industrial production of vaccines; reactors for the industrial production of pharmaceuticals; reactors for the industrial synthesis of nanoparticles; parts and accessories of the aforementioned goods, as far as included in class 11. Technological consultancy; development of chemical synthesis methods and production methods; scientific and technological consultancy relating to the syntheses and production of pharmaceuticals, vaccines and nanoparticles; development and design of chemical reactors and development of production methods; scientific research; pharmaceutical research and development services; laboratory research services relating to pharmaceuticals, vaccines and nanoparticles; working on and evaluation of chemical syntheses; pharmaceutical product evaluation; consultancy relating to pharmaceutical research and development; technological and/or scientific consultancy relating to product development in the field of nanotechnology; technological and/or scientific consultancy in the field of product development; industrial product development; conducting clinical trials for pharmaceutical products; material testing; technological and/or scientific assessment; testing; authentication; quality control.
09 - Scientific and electric apparatus and instruments
11 - Environmental control apparatus
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical laboratory reactors; chemical laboratory reactors for the synthesis of particles, in particular of nanoparticles; laboratory reactors for the synthesis of particles, in particular of nanoparticles; laboratory reactors for the production of individualized medicines and vaccines; parts and accessories of the aforementioned goods, as far as included in class 9. Reactors being industrial chemical installations; reactors for the industrial production of vaccines; reactors for the industrial production of pharmaceuticals; reactors for the industrial synthesis of nanoparticles; parts and accessories of the aforementioned goods, as far as included in class 11. Technological consultancy; development of chemical synthesis methods and production methods; scientific and technological consultancy relating to the syntheses and production of pharmaceuticals, vaccines and nanoparticles; development and design of chemical reactors and development of production methods; scientific research; pharmaceutical research and development services; laboratory research services relating to pharmaceuticals, vaccines and nanoparticles; working on and evaluation of chemical syntheses; pharmaceutical product evaluation; consultancy relating to pharmaceutical research and development; technological and/or scientific consultancy relating to product development in the field of nanotechnology; technological and/or scientific consultancy in the field of product development; industrial product development; conducting clinical trials for pharmaceutical products; material testing; technological and/or scientific assessment; testing; authentication; quality control.
A jet impingement reactor having a small, spheroidal reaction chamber is provided. The reaction chamber exhibits a first and a second fluid inlet arranged at opposite positions of the reaction chamber such as to point at one another, and wherein each of the first and the second fluid inlet comprises a nozzle. The distance between the nozzles is the same or smaller than the diameter of the reaction chamber along the first central axis. Preferably, the nozzles are comprised in fluid inlet connectors that are reversibly insertable into the wall of the reaction chamber such as to provide the first and the second fluid inlet The invention further provides a method of mixing two fluids based on jet impingement using the reactor according to the invention.
B01J 4/00 - Feed devicesFeed or outlet control devices
B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes
B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
The disclosure presented herein provides methods for producing a dispersion of nanoparticles, as for example liposomes, by a method comprising frontally colliding an organic stream with an aqueous stream at raised pressure.
The present invention describes a method for producing nanoparticles, wherein the nanoparticles contain or consist of hydroxypropyl methylcellulose acetate succinate (HPMCAS), and wherein i) HPMCAS is dissolved in an organic solvent in order to obtain an organic solution and ii) the organic solution is mixed with water to precipitate the nanoparticles in order to obtain precipitated nanoparticles and a mixed liquid phase as well as nanoparticles obtained by that method.
A method for producing a liposome dispersion comprising at least one amphiphilic lipid, wherein the method comprises the steps of: providing a first stream (a) comprising an organic solvent, providing a second stream (b) comprising water, wherein at least one of first stream (a) and second stream (b) comprises the at least one amphiphilic lipid, ejecting the first stream (a) and the second stream (b) through pinholes, and frontally colliding the first stream (a) and the second stream (b), whereby the liposome dispersion comprising the at least one amphiphilic lipid is obtained.
The disclosure presented herein provides methods for validating the functioning of an apparatus that produce nanoparticles by precipitating a substance from a supersaturated solution. The validation method is based on the use of reference substances, such as itraconazole. When these reference substances are precipitated in the apparatus, the size of the nanoparticles formed is affected by a parameter of the apparatus.
B01J 4/00 - Feed devicesFeed or outlet control devices
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations; chemical preparations for
medical purposes; adjuvants for medical purposes; chemical
preparations, namely, nanoparticles for pharmaceutical
purposes; chemical preparations, namely, nanoparticles for
medical purposes. Scientific research; pharmaceutical research and development
services; laboratory research services relating to
pharmaceuticals; working on and evaluation of chemical
syntheses; pharmaceutical product evaluation; consultancy
related to pharmaceutical research and development; product
development consultancy in the field of nanotechnology;
product development consultancy; industrial product
development; conducting clinical trials for pharmaceutical
products; materials testing and evaluation; testing,
authentication and quality control.
The present invention describes a method for producing nanoparticles, wherein the nanoparticles contain or consist of hydroxypropyl methylcellulose acetate succinate (HPMCAS), and wherein i) HPMCAS is dissolved in an organic solvent in order to obtain an organic solution and ii) the organic solution is mixed with water to precipitate the nanoparticles in order to obtain precipitated nanoparticles and a mixed liquid phase as well as nanoparticles obtained by that method.
The present invention relates to nanoparticles comprising tacrolimus,a method for providing nanoparticles comprising tacrolimus as well as to nanoparticles comprising tacrolimus that are obtainable by said method. The invention also relates to the nanoparticles comprising tacrolimus for use as a medicament. The invention further relates to a mucoadhesive buccal film containing said nanoparticles comprising tacrolimus and said mucoadhesive buccal film for use as a medicament, especially in pediatric patients.
A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
A fluid reactor for generating particulate fluids by collision, has a housing which encloses a collision chamber, a first fluid nozzle, and a second fluid nozzle oriented opposite thereto in a collinear manner, which is located directly opposite the first fluid nozzle in a jet direction of the first and second fluid nozzles in a common collision zone, at least one rinsing fluid inlet into the collision chamber arranged on a first side of the first fluid nozzle, and at least one product outlet out of the collision chamber arranged on a second side of the second fluid nozzle.
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
B01J 2/04 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
B01J 4/00 - Feed devicesFeed or outlet control devices
31.
NANOPARTICLES COMPRISING A STABILIZED BORONIC ACID COMPOUND
The present invention provides nanoparticles comprising at least one boronic acid compound and at least one stabilizing agent for the at least one boronic acid compound and/or a reaction product of the at least one boronic acid compound and the at least one stabilizing agent, whereby the nanoparticles have a particle size of about 10 to about 1000 nm. The present invention also provides a pharmaceutical composition comprising these nanoparticles and a method for the preparation of these nanoparticlesand the respective pharmaceutical compositions.In addition, the present invention provides nanoparticles and pharmaceutical compositions for the treatment of several disorders, especially multiple myeloma, preferably by parenteral administration.
The present invention describes a method for producing nanoparticles, wherein the nanoparticles contain or consist of hydroxypropyl methylcellulose acetate succinate (HPMCAS), and wherein i) HPMCAS is dissolved in an organic solvent in order to obtain an organic solution and ii) the organic solution is mixed with water to precipitate the nanoparticles in order to obtain precipitated nanoparticles and a mixed liquid phase as well as nanoparticles obtained by that method.
An apparatus (1) for mixing two liquids is provided. The apparatus comprises a static mixer (2), and a first (6) and second (14) feed module for feeding the two liquids to the mixer. The feed modules comprise pressurisable chambers (7, 15) for accommodating flexible containers (8, 16) which hold the liquids to be mixed. The liquids are forced through the static mixer when the chambers comprising the flexible containers are pressurised. Pressurisation is achieved by pressurised gas stored in pressure reservoir chambers (11, 19) that are connectable to the chambers holding the flexible containers. Related methods of mixing two liquids are also provided.
The invention relates to a fluid reactor for generating particulate fluids by collision, having a housing (30), which encloses a collision chamber (40), a first fluid nozzle (10) and a second fluid nozzle (20) oriented opposite thereto in a collinear manner, which is located directly opposite the first fluid nozzle (10) in the jet direction of the nozzles (10, 20) in a common collision zone (50), at least one rinsing fluid inlet (32) into the collision chamber (40) arranged on the side (36) of the first fluid nozzle (10) and at least one product outlet (34) out of the collision chamber (40) arranged on the side (38) of the second fluid nozzle (20).
B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
B01J 4/00 - Feed devicesFeed or outlet control devices
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
A jet impingement reactor having a small, spheroidal reaction chamber is provided. The reaction chamber exhibits a first and a second fluid inlet arranged at opposite positions of the reaction chamber such as to point at one another, and wherein each of the first and the second fluid inlet comprises a nozzle. The distance between the nozzles is the same or smaller than the diameter of the reaction chamber along the first central axis. Preferably, the nozzles are comprised in fluid inlet connectors that are reversibly insertable into the wall of the reaction chamber such as to provide the first and the second fluid inlet The invention further provides a method of mixing two fluids based on jet impingement using the reactor according to the invention.
B01J 4/00 - Feed devicesFeed or outlet control devices
B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes
B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
B01F 35/00 - Accessories for mixersAuxiliary operations or auxiliary devicesParts or details of general application
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
37.
APPARATUS AND METHOD FOR OPERATING A STATIC MIXING DEVICE
